proto-oncogene tyrosine-protein kinase ros, maker-scaffold233_size243130-snap-gene-1.22 (gene) Tigriopus kingsejongensis
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Overview
Associated RNAi Experiments
Nothing found Homology
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000005077 (supercontig:LSalAtl2s:LSalAtl2s268:114393:146217:-1 gene:EMLSAG00000005077 transcript:EMLSAT00000005077 description:"maker-LSalAtl2s268-snap-gene-1.30") HSP 1 Score: 202.216 bits (513), Expect = 1.177e-53 Identity = 95/177 (53.67%), Postives = 130/177 (73.45%), Query Frame = 0
Query: 1539 DLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDR--VVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHP-KVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELLVYEDELAEI 1712
+L + C D+A+GC YL+ M+++HRDIAARNCLVS L D +VKIGDFG AR+IY+D YYRK G L+PI+WMAPESL D YT ++DVWS+G++LWEI++ G+ PYP M++LDV +V N VP CP L LM +CW++ P RP+F++C+ E++ELL+Y+DEL I
Sbjct: 570 NLVRFCLDIARGCLYLTQMRHVHRDIAARNCLVS-LPTSDHTHLVKIGDFGRAREIYRDDYYRKGG--LMPIRWMAPESLEDGVYTHQTDVWSYGIVLWEIISFGK-QPYPGMSHLDVYHYVCNLRKTLDVPLKCPHILYQLMTQCWSYEPINRPSFKECVDEIEELLLYKDELNGI 742 HSP 2 Score: 145.591 bits (366), Expect = 1.932e-35 Identity = 127/460 (27.61%), Postives = 199/460 (43.26%), Query Frame = 0
Query: 1096 AQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQKPTEKEFSVELKDLEPGEIYKIWVEA--RTGSSK-VAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQ--PGHQYQGQIKS-LNPGTQYGLQ-----GVLTFRIGQRT------HTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWNSNNDLVESFELQARIHDSNVTVEDNVTMSNWSVVYADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMES-----NPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV-----QCRD 1528
+T + P P++V + P I V W+ P NG + Y VH + SG + ELK L P +Y IW+ A RT SK + S I +TF L ++ + PRS+ W+SP + F L L +N N S +W S+ + P Y QI + L P T Y ++ G I + + ++WP D + V T PD PL PG PY+ E + + V L W+ + ++ +EL + + + W + Y D WP S L+D+ Y F+VRAKNE GWS FS+ + +NI LIL K +S L+G + I +V + +++ + + +++I V+LN +S NP Y + + + I +Q++ +G GAFG V QC +
Sbjct: 65 TRTEEDIPNNPQHVKGLSKTPSFIFVTWMAPLTFNGS-VAYMVHAKY----------SGITSVYNTTDLEYELKGLNPNSLYVIWISAYLRTNISKGYSSSKRISIKTFKSPPLVQVLQKGPRSLKLHWKSPNSETPVVFHQFL--LYTNQNKSDIRWFPSNSAQRTFPSQNYTTQISTGLYPSTMYIIKVRLFYGEYHINISSQDEQISSLNEFVWPLDDYMLAVNTLPDTPLEPGIPYIFE--NGTYVILIWSGGDMNIDLYELYGK------EINGDGNFYGWBLXYXDVKNFWPPSMLNDSVYKFKVRAKNEHGWSNFSQSSQFININLILQRKK--KSEISILVGSICFSISIFCSIVFYLSFTIIKKTSKNQKS----------ISSISNDLVILNEFRDSFVSANNPLYNL---IGENLSPIKHFSLSQLSFKTKLGSGAFGNVYEGTLQCSE 488
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000005080 (supercontig:LSalAtl2s:LSalAtl2s268:283763:286301:1 gene:EMLSAG00000005080 transcript:EMLSAT00000005080 description:"maker-LSalAtl2s268-augustus-gene-3.12") HSP 1 Score: 157.147 bits (396), Expect = 5.778e-40 Identity = 78/177 (44.07%), Postives = 104/177 (58.76%), Query Frame = 0
Query: 1539 DLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELLVYEDELAEIPSF 1715
DL VAK YLS + IHRD+AARN L+ D ++ K+ DFG ARDI + Y + LPI+WMAPESL N Y+T+SDVWSFG+LLWEI+ LG PYP + DV+ F+ G + P +C L NLM CW PD RP F+ + + ++LL+ E ++ F
Sbjct: 398 DLTSYAYQVAKAMEYLSCKKIIHRDLAARNVLI---DYTLQICKVVDFGFARDIMNHSIYERKSDGRLPIRWMAPESLLYNIYSTRSDVWSFGILLWEIVTLGS-TPYPGKSASDVIKFIREGHRLEKPEHCGRELYNLMYYCWVKKPDDRPCFKTLVKDFEKLLLQETNYIDLRIF 570
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000010076 (supercontig:LSalAtl2s:LSalAtl2s663:706586:714919:-1 gene:EMLSAG00000010076 transcript:EMLSAT00000010076 description:"maker-LSalAtl2s663-augustus-gene-7.10") HSP 1 Score: 150.599 bits (379), Expect = 4.886e-39 Identity = 73/164 (44.51%), Postives = 105/164 (64.02%), Query Frame = 0
Query: 1540 LGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELL 1703
L + DVAKG AYL+D++Y+HRDIA RNCLV+S R+VK+ DFG+ R +Y++ YYR N + +LP++WM+PESLAD +T SDVWS+GVLL+E++ G P+ ++N V+ V G +P +L+ L+ CW +RPT E+ ELL
Sbjct: 107 LTSMALDVAKGLAYLADLKYVHRDIACRNCLVNS----SRIVKLADFGMTRPMYENDYYRFNRKGMLPVRWMSPESLADGLFTPMSDVWSYGVLLYEMITFGSF-PFQGLSNNQVLEHVKAGNTLSIPSGIKAQLETLLKSCWNIASTKRPT----AAEIAELL 261
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000012370 (supercontig:LSalAtl2s:LSalAtl2s905:198215:201197:-1 gene:EMLSAG00000012370 transcript:EMLSAT00000012370 description:"maker-LSalAtl2s905-augustus-gene-2.8") HSP 1 Score: 144.821 bits (364), Expect = 1.691e-37 Identity = 72/182 (39.56%), Postives = 105/182 (57.69%), Query Frame = 0
Query: 1523 QVQCRDPRRLLKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELLV 1704
+Q R RLL L+ ++ ++KG +LS + +HRD+AARN L+ A V+KI DFG+ARD+ YYRK LPIKWMAPE+ N Y+T+SDVWS+G+LLWEI N G P +++ + + G P +CP+ +LM CW +HP++RP + + + LL
Sbjct: 76 HLQKRKNERLL-LSSEEMYSFSNQISKGMNFLSKRKCVHRDLAARNILL----ADKNVIKIADFGMARDVNGKEYYRKRSGGKLPIKWMAPEAFFQNFYSTQSDVWSYGILLWEIANYGEQPYREIFDHITLFKKLDEGYRLSKPSDCPQIFYDLMKYCWKYHPEERPNWENLITLTDSLLA 252
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000003046 (supercontig:LSalAtl2s:LSalAtl2s172:225319:228324:-1 gene:EMLSAG00000003046 transcript:EMLSAT00000003046 description:"maker-LSalAtl2s172-snap-gene-2.21") HSP 1 Score: 142.895 bits (359), Expect = 8.231e-35 Identity = 78/196 (39.80%), Postives = 115/196 (58.67%), Query Frame = 0
Query: 1534 KLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRD---CLHEVQELLVYEDELAEIPSFCQFNPTSHPNS 1726
+L L+ L ++ +YL +++HRDIAARN LVSS + VVK+ DFGL+R I ++YY K + LPIKWM+PES+ ++TT SDVW FGV +WEI+ LG P+ + N DV+ + G +P CP L ++ML+CW++ P RPTF++ L E + +D L + Q + S P+S
Sbjct: 214 RLDLSHLILYSHQLSTALSYLESKKFVHRDIAARNVLVSS----ENVVKLADFGLSRWIEHNSYY-KASRGKLPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLG-VKPFQGIKNSDVIGKLEKGERLSLPSGCPSHLYSVMLQCWSYEPSNRPTFQELKSVLFETLNEIKIQDSLGGYATPWQGDNNSIPSS 403
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000009561 (supercontig:LSalAtl2s:LSalAtl2s615:613087:620800:1 gene:EMLSAG00000009561 transcript:EMLSAT00000009561 description:"maker-LSalAtl2s615-snap-gene-5.55") HSP 1 Score: 131.724 bits (330), Expect = 5.614e-31 Identity = 69/178 (38.76%), Postives = 104/178 (58.43%), Query Frame = 0
Query: 1533 LKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELLVYEDELA 1710
+K++ + I + G YLSD +Y+HRD+A+RNCL+ + VKI DFGL++ + Y+R + +PI+WM E++ NKYT +SD+W+FG+LLWEI +L PY ++N +V+ F+ G P N P+ + +M CW +P RP FR LH +EL E EL
Sbjct: 736 IKVSHVEQVSISKQICNGMVYLSDRKYVHRDLASRNCLID----QSGTVKIADFGLSQRVSLQEYFRGDVSDNIPIRWMPLEAVLHNKYTIESDIWAFGILLWEIFSLA-LQPYYGLSNEEVIKFLKEGNTLGCPENTPKSIYKIMKSCWNPNPSVRPMFR-ILH--RELETIEKELT 905
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000000181 (supercontig:LSalAtl2s:LSalAtl2s1027:89631:95641:1 gene:EMLSAG00000000181 transcript:EMLSAT00000000181 description:"maker-LSalAtl2s1027-augustus-gene-0.8") HSP 1 Score: 129.028 bits (323), Expect = 4.498e-30 Identity = 78/213 (36.62%), Postives = 116/213 (54.46%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLR-CWAFHPDQRPTF---RDCLH-------EVQELLVYE-------DEL---AEIPSFCQFNPTSHPNS 1726
L DL + G YLS Q +HRD+A RN L+ AK+ V+KI DFGL+R++YK S +P+KW++ ESL +T +SD+WSFGV+LWE+ LGR PYP+M +++ F+ +G + P CP+ + ++R CW+ +P +RP++ RD +++EL E DEL E F NPT P+S
Sbjct: 911 LKTEDLLDWAMQITNGMEYLSQKQVVHRDLACRNILI----AKNNVIKICDFGLSRNMYKTYSSSNKKSSPVPVKWLSIESLKYGTFTRRSDIWSFGVVLWEMFTLGRL-PYPNMEYGNLLPFLESGKRMEQPMYCPDSIYYRIMRICWSENPSERPSWIAMRDTFEFMVSNKRDMEELATTEEIRHPNLDELLTNIETNGFIVNNPTYLPDS 1118
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000002397 (supercontig:LSalAtl2s:LSalAtl2s145:1463521:1466086:-1 gene:EMLSAG00000002397 transcript:EMLSAT00000002397 description:"maker-LSalAtl2s145-augustus-gene-15.23") HSP 1 Score: 118.627 bits (296), Expect = 1.020e-29 Identity = 59/169 (34.91%), Postives = 94/169 (55.62%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELL 1703
+T D+ +AKG YL ++++HRD+AARN L++ + Y P+KW++PESL DNKYT+KSDVWSFG+LLWE++ G C PYP + ++ + +G + P +C + +M CW+++PD RPTF++ + ++ LL
Sbjct: 20 ITPQDVIGFSLQIAKGMEYLFGLKFVHRDLAARNVLLT----------------------EGYQ-------FPVKWLSPESLFDNKYTSKSDVWSFGILLWELVXFGGC-PYPGIPPERLVKLLKSGYRMEKPDSCTGEIYEIMTDCWSYNPDARPTFKNLIMRIEILL 158
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000000685 (supercontig:LSalAtl2s:LSalAtl2s1108:63543:67697:1 gene:EMLSAG00000000685 transcript:EMLSAT00000000685 description:"maker-LSalAtl2s1108-augustus-gene-0.17") HSP 1 Score: 110.538 bits (275), Expect = 2.083e-24 Identity = 63/180 (35.00%), Postives = 96/180 (53.33%), Query Frame = 0
Query: 1524 VQC-RDPRRLLKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLAR--DIYKDAYYRK-NGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFV--PNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLH 1697
++C +P ++ L + + +G +YL + + IHRD+AARN LV S + VVKI DFGL+R + KD Y N LPI W APE + K+T+ SDVW+F LWE+ + G P+ + ++ + P+ + PP CP+ +M+ CW+ P +RPTF H
Sbjct: 223 LECLNEPSSRSSFHVSRLSEFSLQICQGMSYLEEKRLIHRDLAARNILVFSKE----VVKISDFGLSRALGVGKDYYQTNFNANLKLPIAWCAPECINFLKFTSASDVWAFSTALWEMFSYG-FQPWAGLTGKQILDAIDEPHSRRLERPPYCPKDYYRIMMECWSHDPIKRPTFARLYH 397
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Match: EMLSAG00000010861 (supercontig:LSalAtl2s:LSalAtl2s721:338828:344970:1 gene:EMLSAG00000010861 transcript:EMLSAT00000010861 description:"maker-LSalAtl2s721-augustus-gene-2.54") HSP 1 Score: 103.99 bits (258), Expect = 2.205e-22 Identity = 58/170 (34.12%), Postives = 88/170 (51.76%), Query Frame = 0
Query: 1534 KLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDI-YKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVP-NGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTF---RDCLHE 1698
++ + ++ +A G YL ++IHRD+A RN L+ A +KIGDFGL R + KD +Y ++ +P W APESL + ++ SD W F V LWE+ + G+ P+ +N ++ + G P CP + L+L CWA P RP F +D L E
Sbjct: 237 RIPITNIWDFAIQIANGMTYLESKRFIHRDLACRNVLL----ATSSRIKIGDFGLMRALTQKDDFYVMTERNKVPFPWCAPESLKNRLFSHASDTWMFAVTLWEMFSFGQ-EPWLGLNGTQILRKIDVEGERLGQPYACPNYIYRLLLECWAKVPTDRPNFESLKDLLTE 401
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|81910548|sp|Q63132.1|ROS1_RAT (RecName: Full=Proto-oncogene tyrosine-protein kinase ROS; AltName: Full=Proto-oncogene c-Ros; AltName: Full=Proto-oncogene c-Ros-1; AltName: Full=Receptor tyrosine kinase c-ros oncogene 1; AltName: Full=c-Ros receptor tyrosine kinase; Flags: Precursor) HSP 1 Score: 221.09 bits (562), Expect = 2.295e-56 Identity = 101/167 (60.48%), Postives = 126/167 (75.45%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLD-AKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQ 1700
LTLADL ++C D++KGC YL M +IHRD+AARNCLVS D RVVKIGDFGLAR+IYK YYRK G+ LLP++WMAPE+L D +T++SDVWSFG+L+WEI+ LG PYP +NLDV+ +V GG + P NCP+ L NLM RCWA PDQRPTF + ++Q
Sbjct: 2043 LTLADLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKHDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGH-QPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMFRCWAQEPDQRPTFYNIQDQLQ 2208 HSP 2 Score: 166.777 bits (421), Expect = 7.109e-40 Identity = 331/1614 (20.51%), Postives = 621/1614 (38.48%), Query Frame = 0
Query: 13 LDSVNGNVFWHTGNEIWTVSKCDPS----SSKRIVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNANVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPS--DNSANPCVWQQWTYDIRLESK---SATEKVFQAEETNL-VTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSL-------------PEGPTDLVLTWIRKGQVFQSDLLGTNHSRVELPFKARHVACRSGDAVLLSTDTSLLSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLW-SESLISDLVIDGLGHRLFFTRKDGSQTVIHQMDLEDLSIPVQVVTILEHSTRS----GSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGGRITDLCVQGAPRQMVPQDLDITPL----TVDLDSLKLEEDS---KLVWRALT----GEVTYHLLIQVHGRQYALQTTTSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF------HNAVNSSII-VRWNPPKLPNGHIT------------GYQMEINSLDTIIVHPDTLE-QVLVELPSQQLHIDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRRIRATYDV-GAIQTLDFQGPKAV--FSQGGSIFALNLINHVRERVLTQ--AELILHLRVDWISNCIFFVAVSGSDYSIRRFSVD------SGVLSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHA----QCSCFQMDPRSPFYFTLRPNIPEQKASLTLLTHDGSLFATD-NGCECQLMRKIPAWS-----QLSSDGSNLYW----KSHEFVQYLNLQEGQISHFNGSSRNEGVI-----IRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQFRAPCT---NSLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALAQTLDGQ-----PGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQKPTEKEFSVELKDLEPGEIYKIWVEA-RTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWNSNNDLVESFELQARIHDSNVTVEDNVTMSNWSVVYADTSPQ---WPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQ-IPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
+DS NG VF+ + I+ V PS + RIV L + S R++ + + L ++L + F + L + + ++ ++ + H E+ V +Q P+P +P +V + FG S A ++W+P A+P WQ WTY++++ S+ T+ T L V ++ T + SVRA S G WS P +L +G L+ G+ SD+ N S ++ + + + G+ + + +S I A A L FE +Y K+ I R +++ V + +D + L W S+ + L G S +L+ W S + L +D L++ +D ++ L S +T + S +L YY +L WI +G +++T +GQ S + G+ + + +P + TP +V S ++E + +++W G V Y + H + A++ + + + L P +++ + W K + + P + S P++ R F + N ++ RWN PK NG +T G ++ V P + Q+ P + +R + G P S +++ + P ++ + G K++F D+D+ ++ T+ + GA+ T+ + + F+QG ++F LNL NH ++ A I + VDWI+ ++F A+ S + F VD S + + I + PL + LY+T ++ +Q+ +S L+P +++ QCSC + T+ + P++ T ++A D GC+C + +PA L+ DG +YW K + G I + R++ ++ ++PF PD + +V +IL A L + LP + T + P + +YY S+ H L E + I+ L+PF+ Y I ++++ + + P E ++L + + G+ PG ++ AT L ++ V W NG + + + P + P+ + S+ + L G+ Y + + A + +S + F P S+ W++P + F F L K + ++ +S G Y I +L P T Y ++ V+ + G+ + + P+ K T P PG P ++E S + N + + + L+ R SN + + ++ W+ V+ + W L + FR A N G+ ++SE ++ + L G + + + ++ + GI + V + V L+ K L + + ELA EL + G +N Y V +P+++E+E +P R +++L +G GAFG+V
Sbjct: 425 VDSYNGYVFYLLRDGIYRVHLPLPSVRDTKAVRIVESGTLKDFAVKPQSKRIIYFNGTMQVFMSTFLDGSAFHRVLPWVPLADVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHI-----EEFGFGNLVIFGSSVQSYPLPGHP-QEVSVLFG------SREALIQWKPPILAIGASPSAWQNWTYEVKVSSQDILETTQVFLNISRTVLNVPKLQSSTKYMVSVRASSPKGPGPWSEPSVGTTLVPATEPPFIMAVKEDGLWSKPLSSFGPGEFLSSDV--GNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHISSIAGA--CALAFEWLGHFLY-WAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDPVGGYLYWTTL-YSVESTRLNGES-SLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGADATITEFAAWSTSEISQNALMYYSGRLFWI-NGFRIITAQEIGQRTSVSV--SEPGKFNQFTIIQTSLKPLPGNFSSTPTVIPDSVQESSFRIEGHTSSFRILWNEPPAVDWGIVFYSVEFSAHSKFLAIEQQSLPV---FTVEGLEPYALFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSLGRYTRKNEVVVEFRWNKPKHENGVLTKSEIFYHISKQSGTNKSTEDWVSVSVTPPVMSFQLEAMSPGYIVSFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLI---SLLGNKIEFLDMDQNQVVWTFSLEGAVSTVGYTADDEMGYFAQGDALFLLNLHNHSSSKLFQDVLASDIAVIAVDWIARHLYF-ALKASQDGTQIFDVDLEHKVKSPREVKICKSHTAIISFSMYPLLSRLYWTEVSDLGYQMFYCNISSHTLHHVLQPKASNQHGRRQCSCNVTESELSGAMTVDTSDPDRP--WIYFTKQQEIWAMDLEGCQCWKVIMVPATPGKRIISLTVDGEFIYWITTMKDDTEIYQAKKGSGAILSQVKAPRSKHILAYSSALQPF-PDKAYLSVASNMV------EASILNATNTSLILKLPPVKTNLTWHGITTPTSTYLVYYMEANRANSSD---------RKHNML-----------ESQENVARIEGLQPFSTYVIQIAVK----NYYSDPLEHLSLGKEIQGKTKSGVPGAVCHINATVLSDTSLLVFWTESHKPNGPKELVRYQLVMSYLAPIPETPLRQDEFPSAR-LSLLVTKLSGGQQYVLKILACHSEEMWCTESHPVSVNMFDTPEKPSALVPENTSLLLDWKAPSNANLTRFWFELQKWKYS------EFYHVKASCSQGPVYVCNIANLQPYTPYNIRVVVVYTTGENSSSI--PESFK-----TKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGNRLMYYTLEVRKSISNDSRDQSL---RWTAVFNGSCSSICTWRSKNLK-GTFQFRAVASNAIGFGEYSE----ISEDITLVEDGFWITETSFILTIIVGIFLVATVPLTFVWHRSLKNHKATKEGLSVLNDNDQELA---ELRGLAAGVGLANACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGEV 1951
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|125677|sp|P00529.1|ROS_AVISU (RecName: Full=Tyrosine-protein kinase transforming protein ros) HSP 1 Score: 204.527 bits (519), Expect = 4.377e-56 Identity = 92/162 (56.79%), Postives = 120/162 (74.07%), Query Frame = 0
Query: 1543 ICCDVAKGCAYLSDMQYIHRDIAARNCLVSS--LDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
IC D+ KGC YL M++IHRD+AARNCLVS + RVVKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T SDVW+FGVL+WE + LG+ PYP ++N++V+ V +GG + P NCP+ +++LM RCWA P RPTF H++QE+
Sbjct: 212 ICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQ-QPYPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKLQEI 372
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|81911840|sp|Q78DX7.1|ROS1_MOUSE (RecName: Full=Proto-oncogene tyrosine-protein kinase ROS; AltName: Full=Proto-oncogene c-Ros; AltName: Full=Proto-oncogene c-Ros-1; AltName: Full=Receptor tyrosine kinase c-ros oncogene 1; AltName: Full=c-Ros receptor tyrosine kinase; Flags: Precursor) HSP 1 Score: 217.624 bits (553), Expect = 2.128e-55 Identity = 99/167 (59.28%), Postives = 127/167 (76.05%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLD-AKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQ 1700
LTL DL ++C D++KGC YL M +IHRD+AARNCLVS D RVVKIGDFGLAR+IYK+ YYRK G+ LLP++WMAPE+L D +T++SDVWSFG+L+WEI+ LG PYP +NLDV+ +V GG + P NCP+ L NLM +CWA PDQRPTF + +++Q
Sbjct: 2044 LTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGH-QPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQ 2209 HSP 2 Score: 173.326 bits (438), Expect = 7.649e-42 Identity = 340/1642 (20.71%), Postives = 623/1642 (37.94%), Query Frame = 0
Query: 13 LDSVNGNVFWHTGNEIWTVSKCDPSS----SKRIVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHD-HAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNANVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSDNS--ANPCVWQQWTYDIRLESKSATE--KVFQAEETNLVTC--VEHGTVFNASVRAVSEGGKSEWSIPVSAQSLPEGPTDLVLTWIRKGQVFQSDLLGTNHSRVELPFKARHVACRSGDAVLLSTDTSLLSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPA-RGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFFT--------RKDGSQTVIHQ--------------MDLED------------LSIPVQVV--------TILEHSTRSGS------LNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGGRITDLCVQGAPRQMVPQDLDITPLT----VDLDSLKLEEDS---KLVWRALT----GEVTYHLLIQVHGRQYALQTTTSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF------HNAVNSSII-VRWNPPKLPNGHITGYQMEI-------------NSLDTIIVHPDTLEQVLVELPSQQLHIDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRRIRATYDV-GAIQTLDF--QGPKAVFSQGGSIFALNLINHVRERVLTQAELILHLRV---DWISNCIFFVAVSGSDYSIRRFSVD--------SGVLSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTH----AQCSCFQMDPRSPFYFTLRPNIPEQKASLTLLTHDGSLFATD-NGCECQLMRKIPAWS-----QLSSDGSNLYW--KSHEFVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQFRAPCT---NSLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALAQTLDGQ-----PGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQKPTEKEFSVELKDLEPGEIYKIWVEA-RTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWNSNNDLVESFELQARIHDSNVTVEDNVTMSNWSVVYADTSPQ---WPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQ-IPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
+DS NG +F+ + I+ V+ PS + RIV L + S R++ + + +L M +D ++L + F + L + + ++ ++ + H E+ V +Q P+P +P +V + FG S A ++W P + A+P WQ WTY++++ S+ E +VF ++ ++ T + SVRA S G WS P +L + +++ ++ L C G LS+D +S + ++ S+Y K + +R E IP+ G AL + L L W I S+ + + L L++D+ +D +G L++T R +G +++ Q +DL D + + V+ TI E + S S L YY +L WI +G +++T +GQ S + + + + +P + TP V S ++E + +++W G V Y + H + ++ + + + L P T +++ + W K + + P + S P++ R F + N ++ RWN PK NG +T +++ + + ++ P Q+ P + +R + G P S +++ + P ++ + G K+ F D+D+ ++ T+ + G + T+ + F+QG ++F LNL NH + L Q L+ +RV DWI+ ++F A+ S + F+VD V + HT I + PL + LY+T ++ Q+ +S L+P +++ +QCSC + T+ + P++ T ++A D GC+C + +P L+ DG +YW K+ + Q ++G + + + I + Q P K L + TIL A L + LP + T + P + IYY S+ H L E + I+ L+PF+ Y I ++++ + + P E + L + + GQ PG ++ AT L ++ V W NG + + P + P+ K S+ + L G++Y + V A +S + F P S+ W++ + F F L K N ++ +S G Y I L P T Y ++ V+ + G+ + + P+ K T P PG P ++E S + N + + L+ R SN + S W VV+ + W L + FR A NE G ++SE ++ + L G++ + + ++ + GI + V + V L+ K L + + ELA EL + G +N Y V +P+++E+E++P R +++L +G GAFG+V
Sbjct: 426 VDSYNGYLFYLLRDGIYRVNLPLPSGRDTKAVRIVESGTLKDFAVKPQSKRIIYFN-DTMQLFMSTFLDGSAFHRVLPWVPLVTVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHI-----EEFGFGNLVIFGSSVQSYPLPGHP-QEVSVLFG------SREALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKGPGPWSAPSVGTTLVPATEPPFIMAVKEDGLWSKPL------------------CSFGPGEFLSSDVGNVSD----------------MDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPSIVGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKL----LVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWI-NGFRIITAQEIGQRTSVSV--SEPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQESSFRIEGHTSSFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIF---TVEGLEPYTLFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLI---SLLGNKIVFLDMDQNQVLWTFSLEGDVSTVGYTTDDEMGYFAQGDTLFLLNLRNHSSSK-LFQDALVSDIRVIAVDWIARHLYF-ALKASQNGTQIFNVDLEHKVKSPREVKTCKAHTT--IISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRSQCSCNVTESELSGAMTVDTSDPDRP--WIYFTKRQEIWAMDLEGCQCWKVIMVPTIPGKRIISLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDMVEATILYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSD---------RRHKML-----------ESQENVARIEGLQPFSMYMIQIAVK----NYYSEPLEHLPLGKEIQGQTKSGVPGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAK-LSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLDWKARSNVNLTGFWFELQKWKYN------EFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSI--PESFK-----TKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISN---DSQNQSSRWKVVFNGSCSSICTWRSKNL-KGTFQFRAVAANEIGLGEYSE----ISEDITLVEDGVWITETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDNDKELA---ELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFGEV 1952
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|126302596|sp|P08922.3|ROS1_HUMAN (RecName: Full=Proto-oncogene tyrosine-protein kinase ROS; AltName: Full=Proto-oncogene c-Ros; AltName: Full=Proto-oncogene c-Ros-1; AltName: Full=Receptor tyrosine kinase c-ros oncogene 1; AltName: Full=c-Ros receptor tyrosine kinase; Flags: Precursor) HSP 1 Score: 212.231 bits (539), Expect = 1.119e-53 Identity = 98/161 (60.87%), Postives = 120/161 (74.53%), Query Frame = 0
Query: 1544 CCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKD-RVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELL 1703
C D++KGC YL M +IHRD+AARNCLVS D R+VKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +TT+SDVWSFG+L+WEI+ LG PYP +NLDV+ +V GG + P NCP+ L NLM +CWA PDQRPTF H +Q+ L
Sbjct: 2060 CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH-QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTF----HRIQDQL 2215 HSP 2 Score: 154.066 bits (388), Expect = 5.879e-36 Identity = 299/1441 (20.75%), Postives = 559/1441 (38.79%), Query Frame = 0
Query: 191 PCVWQQWTYDIRLESKSATE--KVFQAEETNLVTC--VEHGTVFNASVRAVSEGGKSEWSIPVSAQSL-PEGPTDLVLT------WIRK------GQVFQSDLLGTNHSRVELPFKARHVACRSGDAVLLSTDTSLLSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFFTRKDGSQTVIHQMDLEDLSIPVQVVTILEHSTRS----GSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGGRITDLCVQGAPRQMVPQDLDITPL----TVDLDSLKLEEDS---KLVWRALT----GEVTYHLLIQVHGR-----QYALQTTTSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF----HNAVNSSIIV---RWNPPKLPNGHITGYQMEINSLDTIIVHPDTLEQVLVEL-------------PSQQLHIDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRRIRATYDV-----GAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVLTQAELILHLRV---DWISNCIFFVAVSGSDYSIRRFSVD------SGVLSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQ-----CSC----FQMDPRSPFYFTLRPNIPEQKASLTLLTHDGSLFATD-NGCECQLMRKIPAW------SQLSSDGSNLYW--KSHEFVQYLNLQEGQISHFNGSSRNEGVIIRP---FCPDCQMTPIKQCLVPSLVEQRV--TILEAGEDWLRVSLPQFRAPCT---NSLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQK--GKPSQQTIPTELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQKPTEKEFSVELKDLEPGEIYKIWVEA-RTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWNSNNDLVESFELQARIHDSNVTVEDNVTMSNWSVVYADTSPQ---WPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKSA---LGIQRHRELELATIHELPVMLNGGMESNPTYGVQ-IPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
P WQ WTY++++ ++ E +F ++ ++ + SVRA S WS P +L P ++ W + G+ SD+ N S ++ + + + GD + + + +S + A A L FE +Y K+ I R +++ V + +DS+ L W S+ + L G S + +S + L +D L++ +D ++ L S +T + S +L YY +L WI +G +++T +GQ S +L R + + +P + TP +V S ++E ++ +++W G V Y + H + Q++L T E L P +++ + W K P+ +L P + S P++ R F N + +V RWN PK NG +T +++ N + I + + + V + P + +R + G P + ++ + P ++ + G K+ F D+D+ ++ T+ T D + +++G S+F L+L N L Q L+ + V DWIS ++F A+ S ++ F VD + + I + PL + LY+T +++ +Q+ + + L+PT+T+ Q CSC F++ + + + L ++A D GC+C + +PA L+ DG +YW + + Q ++G NG+ ++ +R M P SL V TIL A L + LP + T + P + +YY + + +S S L+ Q I LI+DL+PF+ Y I ++++ P + P + I +T +G P + + T ++ ++W NG + + P + P + ++ + L G IY + V A + +S + + F+ P S+ F W++P + F L K N ++ +S G Y I +L P T Y ++ V+ ++ G+ + + P+ K T P PG P ++E S + N + + L+ R SN N+ W + + + W L + FRV A N G+ ++S ++ +IL + + ++ + IVGI V+ + + ++ RR ++KSA + + + + ELA EL + G +N Y + +P+++E+E++P R ++TL +G GAFG+V
Sbjct: 602 PSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDI--GNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGA--GALAFEWLGHFLY-WAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTL-YSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWI-NGFRIITTQEIGQKTSVSVL--EPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVE--------GLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLIT---LLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNE--MGYYAEGDSLFLLHLHNRSSSE-LFQDSLVFDITVITIDWISRHLYF-ALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSG------AMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKG-----NGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS----------SDLKYRILEFQDSI---------ALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEI-WGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGR-LTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYN------EFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSL--PESFK-----TKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNL---RWKMTFNGSCSSVCTWKSKNLK-GIFQFRVVAANNLGFGEYSG----ISENIILVGDDFWIPETSFILTI---IVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELA---ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEV 1959
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|112856|sp|P20806.1|7LESS_DROVI (RecName: Full=Protein sevenless) HSP 1 Score: 211.46 bits (537), Expect = 1.837e-53 Identity = 104/225 (46.22%), Postives = 142/225 (63.11%), Query Frame = 0
Query: 1532 LLKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDA--KDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL--------LVYEDELAEIPSFCQFNPTSH------PNSVSMH-NSRDTWKTS 1739
L KL L +L +C DVA GC+Y+ DM ++HRD+A RNCLVS A R+VKIGDFGLARDIYK YYRK G+ LLP++WMA ESL D ++T+SDVW+FGVL WEI LG+ PY NN +V+ V GG + P CPE+L L+L+CW P +RP+F+ CL +Q L ++ DE + + C F P + P +++H +++DT T+
Sbjct: 2324 LSKLQLPELLSMCLDVANGCSYMEDMHFVHRDLACRNCLVSDGAAIGGRRIVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMALESLVDGLFSTQSDVWAFGVLCWEIFTLGQ-QPYAARNNFEVLAHVKEGGRLQQPERCPEKLYALLLQCWRSEPWERPSFKRCLSTLQALSSDLRRTEMLATDETPLVSALCAFKPDAKVRFDDAPQRLTLHLDAKDTVSTT 2547 HSP 2 Score: 98.9821 bits (245), Expect = 2.992e-19 Identity = 235/1101 (21.34%), Postives = 414/1101 (37.60%), Query Frame = 0
Query: 516 DLDITPLTVDLDSLKLEE-----DSKLVWR-ALTG---EVTYHLLIQVHGRQYALQTTTSELDLAQEIASLTPNTE----VRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF--------HNAVNSSIIVRWNPPKLPNGHITGYQMEINSLDTIIVHPDTL-EQVLVELPSQQLHID--LRCQNNAGLSPASTLLIQNRFVL------PSLPQILIYQGIQGGKLDFYDLDRRRIRATYDVGAIQTLD-FQGPKAVFSQGGSIFALNLINHVRERV-----LTQAELILHLRVDWISNCIFFVAVSGSD-----YSIRRFSVDSGVLSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQCSCFQMDPRS-PFYFTLRPNIPEQKASLTLLTHDGSL--------FATDNGCECQLMRKIPAWSQLSSDGSNLYWKSHEFVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAG-----EDWLRVSLPQFRAP--CTNSLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALA----QTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQKPTEKEFSVE-LKDLEPGEIYKIWVEARTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAW-----NSNNDLVESFE-LQARIHDSNVTVEDNVTMS--NWSVVYADTSPQW-------PISGLSDAAY-----LFRVRAKNE-FGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKSALGIQRHRELEL---------ATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
D + PL V DS+ ++E D ++ W+ A +G V Y LL++ HG + + L+L A +T + +R+++ + W L TP + P+ LR F A N S ++RW+ P+ G Q I+ +H + L Q +E + L + R Q A ++ L S+P++L G+LD R+++ + ++ L QG + + + L++HV + +AE +L L VDW+ +++ + +D YS+ D +L + + P L QL L+ L R +L+ S A S + + P + + +L L+ H G L T + QL QL+ D LY + V+ + Q+ +E ++R + + Q P ++CL L+ LE+ E + LP A C +P + + + EL S+ H + L L I L+P+ Y L Q G QQ + E + L T P P N + AL P +E++WL P + Y +H++L T + Q+ + V+ L L+P +Y++W++A SK S + ++++ + ++ +T W P A+ + L+ L + G+ Q ++ L P T+Y + L + Y P ET DAP PG+P +E ++ ++W N + L+ + E LQAR + T+S W+ QW +S + + LFRVRA+N GW +SED+ + + K G+L+ I+ ++ VL + L R K+ RHR +L + + L + T+ + + S+ ++ +P++ N++TL+ F+G GAFG+V
Sbjct: 1221 DEGVRPLAVPPDSVHIDEGGHWNDFRVRWQPAASGGNHSVCYKLLLE-HGSERLI-----TLELLTPFARITQLAQAPLGLRISITPHTAWRAGSTTRVQLDTPVAAPTQPRRLRVFVERQAAPLQLAPNVSALLRWDVPEEHAGS-QSLQYRISCWRGSELHSELLLNQSTLEARVEHLQPEETYRFQVQAHVAATGLAAGATSHALHVSPEVQSVPRLLYANAEHIGELDLDTGHRKQL--VHTASPVEHLVVLQGEQRLLWVNEHV---ELLSHVPGKAPAKLARMRAE-VLALTVDWVQRIVYWAELDAADGGCVIYSLDLCRFDGRILQG--------ERLWSTPRGQLLRDLVALPHARQLVWLQHDLDSRNATLQGRSL-ANGSALTFEGVTLPLWRLFEGSQEPLAETLNLVDHLGRLCVYHVARQLCTSSALRAQLNLLNDDIGQLAQDPGYLYALRNGSVRAYGRRRQQLEFLLELQPDEVRLLRAY--NYQAYPSRRCL---LLPTTAAALESTPSSCEETQCSLQLPALSAAPDCPLPVPGLNYQLNLSSSSRSAQLELRSL-------HSAAGLTLN--------------ISQLQPYQAY--ELRAQVGSYYQQQLGQEPLQLPVLTLHTAAATPSAPRNFSGRALSPSELELSWLAPLELRSASVYYTLHWQLQLEDTEEQSQEQPAQEQRVETAGVQRLTGLQPARLYQVWLQAHATPSKYNSSGRLLIRSYAPLPPLQLIELNAYGMTLAWPGTP-DALSSLTLECQSLREQLQFN-----------VAGNHTQMRLAPLQPKTRYSCRLALAYAATPGAPIYFGPSHE----YETLGDAPSAPGRPQ-LEHIAGEIFRVSWTPALDNGSPILLYNLEALQARRTNRRRRRRRETTLSLLPWAEEPLVIEDQWLDFCNTTELSCIVRELHTRRLLLFRVRARNRPHGWGPYSEDSERIAEPFVSPEK------RGSLV---LAIIAPAAIVSSCVLALVLVRKLQKR------RHRAKKLLQQSRPSIWSNLSALQTQQQLLAARSRTFSMSL-SDADIALLPQINWNRLTLLRFLGSGAFGEV 2238
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|14424434|sp|P13368.2|7LESS_DROME (RecName: Full=Protein sevenless) HSP 1 Score: 202.601 bits (514), Expect = 1.084e-50 Identity = 91/172 (52.91%), Postives = 121/172 (70.35%), Query Frame = 0
Query: 1527 RDPRRLLKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDA---KDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDC 1695
++P+ L+L++L +C DVA GC+YL DM ++HRD+A RNCLV+ + R VKIGDFGLARDIYK YYRK G+ LLP++WM+PESL D +TT+SDVW+FGVL WEI+ LG+ PY NN +V+ V GG + PP C E+L +L+L CW P +RP+FR C
Sbjct: 2307 QEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQ-QPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRC 2477 HSP 2 Score: 97.8265 bits (242), Expect = 7.590e-19 Identity = 116/498 (23.29%), Postives = 204/498 (40.96%), Query Frame = 0
Query: 1063 IKDLEPFTRY---GIYLSLQKGK---PSQQTIPTELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHY--ELHKVITTSRIPSGHRQKPTEKEFSVELKDLEPGEIYKIWVEARTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWNS---NNDLVESFELQARIHDSNVTVEDNVTMSN---------WSVVYADTSPQW-------PISGL-----SDAAYLFRVRAKN-EFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKSALG---IQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
+ DL PFTRY GI S + K P+ P EL+ + T P PP N + L P +EV+WLPP+ + + Y +H+ EL R ++ E + L ++PG Y +WV+A +K S + ++F+ + ++ P S++ W P + + Q L+ +A Q L G+ + ++ L P T+Y + +L + Y + ET DAP PG+P +E ++E + W + N + + L+A S++ N W+ QW +S + S LFRVRA++ E GW +SE++ + + K G+L+ I+ ++ VL + L R K+ +Q+ R + + L N + + S+ ++ +P++ +Q+ L+ F+G GAFG+V
Sbjct: 1757 LTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASAT----PSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTP-DPLGSLQ-----LECRSSAEQ------LRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLY----HGTAEVYETLGDAPSQPGKPQ-LEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEK------RGSLV---LAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTL-SDADIALLPQINWSQLKLLRFLGSGAFGEV 2223
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|57013873|sp|P08941.3|ROS1_CHICK (RecName: Full=Proto-oncogene tyrosine-protein kinase ROS; AltName: Full=Proto-oncogene c-Ros; AltName: Full=Proto-oncogene c-Ros-1; AltName: Full=Receptor tyrosine kinase c-ros oncogene 1; AltName: Full=c-Ros receptor tyrosine kinase; Flags: Precursor) HSP 1 Score: 201.445 bits (511), Expect = 2.128e-50 Identity = 90/162 (55.56%), Postives = 119/162 (73.46%), Query Frame = 0
Query: 1543 ICCDVAKGCAYLSDMQYIHRDIAARNCLVSS--LDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
IC D+ KGC YL M++IHRD+AARNCLVS + RVVKIGDFGLARDIYK+ YYRK G+ L+ ++WMAPESL D +T SDVW+FGVL+WE + LG+ PYP ++N++V+ V +GG + P NCP+ +++LM RCWA P RPTF H++QE+
Sbjct: 2075 ICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDIYKNDYYRKRGEGLINVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQ-QPYPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKLQEI 2235 HSP 2 Score: 160.229 bits (404), Expect = 8.317e-38 Identity = 333/1624 (20.50%), Postives = 602/1624 (37.07%), Query Frame = 0
Query: 37 SSSKRIVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNAN--VLHQLMGDNRSGHFQS-------SFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSDNS--ANPCVWQQWTYDIRLESKSATEKVFQAEE--------TNLVTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSLPEGPTDLVLTWIRKGQVFQSDLLGTNHSRVELPFKARHVACRSGDAVLLSTDTSLLSAQGQILFKANAEISG-----------LLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDL-WSESLISDLVIDGLGHRLFFTRKDGSQTVIHQMDLEDLSIPVQVVTILEHSTRS----GSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGGRITDLCVQGAPRQMVPQDLDITPL----TVDLDSLKLEEDSK---LVWRALTGEVTYHLLIQVHGRQYALQTTTSELDL--------AQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF------HNAVNSSII-VRWNPPKLPNGHITGYQM------EINSLDTII------VHPDTL-EQVLVELPSQQLHIDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRRI-------RATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVLTQAEL--ILHLRVDWIS-------------NCIFFVAVSGSDYSIRRFSVDSGVLSNVTHTQDDIQHM-------ELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQCSCFQMDPRSPFYFTLRPNIPEQKASLTLLTHDGSLFATD-NGCECQLMRKIPAW-----SQLSSDGSNLYW--KSHEFVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQFRAP--CTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKF--IIYDVHYELHKV-----ITTSRIPSGHRQKPTEKEFSVELKDLEPG--EIYKIWVEARTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFI--WRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWNSNNDLVESFELQARIHDSNVTVEDNVTMSNWSVVY---ADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFL-----------RRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQ-IPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
S++ +V L I+F S RL+ + + ++ + +D L P M F Y D+ + V H+ + S F + E +F+ QP P+P P L V + FG S A + W P + + + WQ WTYD+++ S+S E+ + NLV+ E + SVRAVS G+ WS P + E + + + +++ L P R+++ L S+ Q + K L F+ + +Y K++ I R +V+ VK L +DS+ L W T V S+ IL+ L +S + L +D L++ +DG ++++ + S +VT + + S +L YY +L WI + + +T + QS S + + +P + TP +V S K++ +S ++W A T + V ++T SE L + ++ L P T ++ + W K+P L P + S P + R + H ++ +RW+ P+ NG +T +++ E + DT++ V P L + E P + ++ + G P S + +N + +P ++ + KL D+D R D+ D K + S+F LN+ + ++ L + + VDWI+ +FF+ + S++ ++ G ++ + + ELD + YY L + + + G + + C+ + + P + +K L + ++A+D + C C + KIP++ L+ D +YW + E+ + + H N + I + Q P K+CL P L ++ TIL+ +SLP C + S P + +++ I S E+ + H S L+ + IQ P +I +L+PF+ Y I ++++ +Q + A++ TL G P +++ L TI ++W P NG I Y + L + + S P+G S + DL+ G ++K+ + + ++S + A+TF P + PR+ +F WR+P +F F L ++ S + P ++ G Y + P Y ++ + + G ++ S +T P PG P E S + N + + L++R N N S W VVY D W L + + FR A N G ++S+ +SK + + IV +IG +V+ + II L R+P + ++ +EL +L M +N Y V +PS+ E+E +P R+++ L +G GAFG+V
Sbjct: 453 SAASLVVKSHTLRDFMINFQSKRLIFFN-KTEQAFVSGFLDGSEFHTL-----RAHVPLDDMES---FVYEDNIFTVTDGRAVFHEEISQVGSSSFNEYVVDCSLEYPEYFGFGNLLFYAASTQPYPLPTLPRL-VTVLFG------SDQAVISWSPPEYTIGTSRSAWQNWTYDVKVSSQSTFEEEWVVSNITDTRFAVKNLVSFTE----YEMSVRAVSPAGEGPWSEPFRGMTFEEAEEEPYILAVGAEGLWKQRLDSYGPGEFLYP-HIRNISDLDWYNDTLYWSNSMGKVQTWSMNKKEGTTENSYVPDIKNARMLAFDWLGQCLY-WAGKANTIYRKSLLGDHMDVVAHVVYVVKDLAVDSVNGYLYWAT--TYTVESARLNGEEYLILQEHLQFSGKQVVGLALDLTSGFLYWLVQDGLCLNLYRISICKESCGNIMVTEISAWSVSEVSQNALQYYSGRLFWI-NRLKFITTQELNQSISIPF--SEPAEFAAFTLVHTSLKPLPGNFSFTPKVIPSSVPESSFKIKGNSSSFHIIWNASTDVQWGTVFYCVGSNALQMRTLESERCLHPHDLTVPSYKVDWLEPFTLFDFSVTPYTYWGKAPTTSVYLRAPEGVPSAPANPRIYVLHSNTHEGEEKVLVELRWDKPERDNGVLTQFRVYYQLLYESGAADTLMEWNVSDVKPTALLFSIRDEHPRLTVRFQVQAFTSVGPGPMSDVAQRNSSDIFPVPTLITFSS---NKLFLTDIDSNHTIWEVLTNRNIKDICYTADDD----KVYYILEDSLFLLNVQSTSESQLFEDVFLRNVTAITVDWIARHLFVAMKTSWNETQVFFIDLELKTKSLKALNIQLGKRNSTISSLLSYPFLSRLYWIEELDYGSRMFYYDILNNTMYHI-------LGYESVEEKMRNYCNCNVAEAELGRPISIDV---TDIKKPQLLFIRGRDEIWASDVDACHCWRITKIPSFQGTKIGSLTVDKQFIYWTIEKKEYTEICLADKESTRHSLQRKANHELKILAYSSAMQSYPDKKCLTPLLDTEKPTILDTTNTSFTLSLPSVTTQQLCPSISQPTPTYLVFFREITSNH---------ENSTYHFSTLLQKTLEIQEP-----IAVINNLKPFSTYAIQVAVKNYYSNQNQLAVGREAISTTLYGVPEGVDSIKTVVLSDTTINISWSEPLEPNGPLESIRYQISVNLLSLFPEAPLRKSEFPNG--------TLSWSVSDLQSGTNNLFKV-LAFHPNENWFSESVPVIAKTFETPLSP--SNIIPRNTSFQLEWRAPLHINGTSFWFELSKWQTR---SDWFSPAS-TTCTVGPVYTCNLTGTLPSANYLVRATVVYVTGMKS-------TSSPTSFKTTAGVPSKPGTPKRAEDSKNSVQWEKAEDNGSNLTYYILESRKQSGNT----NKVKSLWVVVYNGSCDNICTWKAENL-EGTFQFRAAAANMLGLGEYSD-----------TSKDIVLAKDTVTSPDITAIVAVIGAVVLGLTIIILFGFVWHQRWKSRKPASTGQIVLVKEDKELA-----QLRGMAETVGLANACYAVSTLPSQAEIESLPAFPRDKLNLHKLLGSGAFGEV 1975
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|341941008|sp|P08923.3|LTK_MOUSE (RecName: Full=Leukocyte tyrosine kinase receptor; Flags: Precursor) HSP 1 Score: 187.578 bits (475), Expect = 4.782e-47 Identity = 88/172 (51.16%), Postives = 116/172 (67.44%), Query Frame = 0
Query: 1529 PRRLLKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQ 1700
P +L LT+ DL Q+ D+A+GC YL + +IHRDIAARNCL+S A RV KIGDFG+ARDIY+ +YYRK G++LLP+KWM PE+L + +T+K+D WSFGVLLWEI +LG PYP N +V+ F+ G P NCP + +M +CW P+ RP F L +Q
Sbjct: 605 PGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGA-SRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYM-PYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQ 774
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|308153655|sp|P06213.4|INSR_HUMAN (RecName: Full=Insulin receptor; Short=IR; AltName: CD_antigen=CD220; Contains: RecName: Full=Insulin receptor subunit alpha; Contains: RecName: Full=Insulin receptor subunit beta; Flags: Precursor) HSP 1 Score: 182.57 bits (462), Expect = 6.359e-45 Identity = 84/157 (53.50%), Postives = 112/157 (71.34%), Query Frame = 0
Query: 1536 TLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTF 1692
TL ++ Q+ ++A G AYL+ +++HRD+AARNC+V A D VKIGDFG+ RDIY+ YYRK G+ LLP++WMAPESL D +TT SD+WSFGV+LWEI +L PY ++N V+ FV +GG+ P NCPER+ +LM CW F+P RPTF
Sbjct: 1132 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV----AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE-QPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTF 1283
BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Match: gi|2497545|sp|Q05688.1|IGF1R_BOVIN (RecName: Full=Insulin-like growth factor 1 receptor; AltName: Full=Insulin-like growth factor I receptor; Short=IGF-I receptor; AltName: CD_antigen=CD221; Contains: RecName: Full=Insulin-like growth factor 1 receptor alpha chain; Contains: RecName: Full=Insulin-like growth factor 1 receptor beta chain; Flags: Precursor) HSP 1 Score: 176.407 bits (446), Expect = 1.477e-44 Identity = 81/166 (48.80%), Postives = 113/166 (68.07%), Query Frame = 0
Query: 1536 TLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQE 1701
+L+ + Q+ ++A G AYL+ +++HRD+AARNC+V A+D VKIGDFG+ RDIY+ YYRK G+ LLP++WM+PESL D +TT SDVWSFGV+LWEI L PY ++N V+ FV GG P NCP+ L LM CW ++P RP+F + + V++
Sbjct: 381 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV----AEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSVKD 541
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|307166553|gb|EFN60620.1| (Proto-oncogene tyrosine-protein kinase ROS [Camponotus floridanus]) HSP 1 Score: 426.017 bits (1094), Expect = 1.077e-117 Identity = 453/1835 (24.69%), Postives = 780/1835 (42.51%), Query Frame = 0
Query: 11 LQLDSVNGNVFWHTGNEIWTVSKCDPSSSKR-------IVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEER---QRPFQSMSEGILFHYNDSYYWTN-ANVLHQLMGDNRSGHFQSSF--KEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAEETNLVTCVEH---GTVFNASVRAVSEGGKSEWSIPVSAQSLPEGPTDLVLTWIRKGQVFQSDLLG---------TNHSRVELPFKARHVACRSGDAVLLSTDTSLLS---AQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFF-TRKDGSQTVIHQMDLEDLSIPV------QVVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTI----LLGGRGGRITDLCVQGAPRQMVPQDLDITPLTVDLDSLKLE---EDSKLVWRALTG--------EVTYHLLIQVHGRQYALQTTTSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF-----------HNAVNSS--IIVRWNPPKLPNGHITGYQME---INSLDTIIVHPD------TLEQVLVEL-PSQQLHIDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRRIRAT---YDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVLTQAELILHLRVDWISNCIFFVAVSGSDYSIRRFS------------VDSGVLSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGR-IKSLKPTSTHAQCSC-FQMDPRSPFYFTLRPNIPEQKASLTLLTHDGSLFATD-NGCECQLMR---KIPAWSQLSSDGSNLYWKSHEFVQYLNLQEGQISHFNGSSRNEGVI----------IRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQFRAP--CTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPT--ELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSR-----IPSGHRQKPTEKEFSVELKDLEPGEIYKIWVEARTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRS--PPIKAIQAF--QFRLVPLKSNLNASQYQWPMELS---SIQPGHQYQ--GQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAW---NSNNDLVESFELQARIHDSNVTVEDNVTMSN--WSVVYADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVL------------VVVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNG-GMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQVQCRDPRRLLKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
+++D NG +FW ++ + D S+ + I+ LG+ +D + RLLV + ++ L D+ F++R Q P + + N +YWTN ANVL + + +F + + + D + + QPIPVP+NP V+ G + A++ W+ S +Q W+Y++ + +S E + Q + L V H + ++ A + G+ WS ++L +G +L W + +SD+ G TN E F V+ ++ +++L + Q+ + + + S+ +Y PK I R S +E + + VK L +DSL A L W G ++ + L G + R ++++ + L +D +++ R S +++++ + IP+ + V++L+ G + Y+ + L W+QDG V DL GQ+ + I L G + D + P+ + + + ++P VD++S+++E + + W + EV + I + TT + + +I P + + VT+ A + W + K L +P + + P RAF H + + +I RWN P+ NG I Y ++ I + + I + D TLE + L + + +R G SP + L+ + +PQ+L+ + DLD R I T + + L+F+ S+ + + ++L L +DW++ +++ + ++ R S V +N+ I +++ P +LY+ + + + ++ L GR ++ + + C+C F P + NI QK + ++ +G L D GC C ++ K + L+ D N+YW + + +++ N + ++ I I F Q P +CL+P + + A + V+LP+ C N SLP + I+ E +G +LQ E ++ I++L+PFT Y + L L Q +PT L + T G+P PEN T L P V W+PPK+ N + Y+VH+ ++ SR + Q + F LK P + Y+++V + + E +T + S P T + RSV + S P I ++ Q++ V L + W + + ++ QY+ I++L P T Y + +L + +IWP D +R +T D P PG+P V ++ S L W ++ V ++L+ I D+ +DN N W++ Y T W I G D FRVRAKN +G+ +SE + I L S+ GL + + G++ I+ ++ + V I LR+ + + L H+ + L G ++++P + + E D+ R L Q D R L L DL +C DV +GC YL ++ ++HRD+A RNCLVS+ D ++RVVKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVL+WEI +LG+ PYP NL+V+ +V GG P NCP L LM+RCW D RP+F+ CL + L
Sbjct: 341 IEVDPYNGYIFWVVKEGLFKLDLADISNGVKHEVQPYLILKDGNLGAFTVDHMNFRLLVAHHRNNTVIALPFYGRDY-------FDQRPNIQTPIFNHVVSLAMA-NGLFYWTNGANVLTEGYHHEQKKYFHNFYLDRSDTNFISVNVLMNASQPIPVPVNPPTGVQAVLG------AEKAKISWQAPHLLGSQGKGAYQNWSYELEIIDESTGETIHQKDIVGLSHTVYHLREKSKYSIKAAAYTNAGRGPWSAEFRGRTLTDGSHASIL-WSSNEGLLRSDVTGENIDTLISKTNLRESESEFHIVDVSWYKDVLYIVGNNSALYCYNVSTHQLTRLITHSVGSVAVDWLSKKLYWANPKQQIITRANLNGSQQEPMILAI--VKELMIDSLEAYLYW-STGHAVEVARLNGQNRRYYHSDEIFNGKQVMGLTLDTENRYVYWIVRSYESGSIVYRAPTSE-RIPMNHQIVPEKVSVLKDPNVQGPVCYFSEHLLWLQDGTNAVIGDLSGQNTAVINGITLSGLHMVAVMDPALHQYPKNLTSETVMVSPNAVDINSIRVEGTWRNFNISWDPVENINYGTVFYEVKFADYINTNSNPEITNETTIPYNNSDQIL---PYSVLEVTVKAFTYWESAHNSRKILKSPESMPTQPMFPRAFVDKEFHHEFRHHEFITNDRLVIFRWNQPQFTNGVIERYMVQCWFIENQNRIQICNDQNIPASTLEYTVHNLRRNMTYYFQVRAYTKIGPSPYTDLINVSTTYENPVPQLLV---ATADAVRMSDLD-REINYTLTRHSATDVNYLEFENEIYWISEMQELVTSEINGANATKILALKNSAHSLCIDWVARNLYWTEYNSTNSYNRENSGYIMKLDLTMWKVGEVKYNNIVKRGRYIPVLDILPSLRSLYWIEAINDRGII--MQSDLDGRNVQPFFKNNVNKTCTCPFSSLSVMPMMTVDKTNI--QKPMIYWVSMEGHLNVADIYGCMCNVVYADFKTATLTSLTVDKVNIYWANATENRIYFMKKEYPFSMNKENMSKPEIKSVYLSNVRHIIAFGKSLQTYPATKCLIPRRKAYTIERVNATATSIVVNLPETNPEIGCENYSLPSTLYVIHVRCQECEG-------------------FELQT-----YERHYE--IQNLKPFTNYTLQLILSNVYIKQYKLPTLSGLDVVLMTDPGKPYAPENFTVQVLTPTLAAVYWMPPKILNCAAVHYEVHWISPLLVNGSRHKGEQVMKDKLQLTKDGRFFTMLKPFLPNQEYQVYVRVYPVNFTNLYN-ETLKKTINMYSEPNNLTLSERSVNSMNISWIPSINLTISYTLQYKDVSLDTRCPMQNCDWQIADNFEKALTELKQYKITYHIRNLQPRTLYKFRLILKY--STYAEDFIWPSD-ERFTFQTLGDVPSAPGKPTVT-RLRNSVYQLNWEPAQAHGSQVTLYQLEGLITDN--YKQDNEATENEYWNLYYNGTDNYWIIPGDIDQYVKFRVRAKNAYGFGAWSESSSI--IDLTESAGGLINITAQQHLPFMLGLIVIVIIVFQGVAKDLEGPGITPVAIKMLRKDASSQEKTEFLQEARLMSHFRHKHVLRLLGVCLDTDPP--LLVLELMEAGDLLSYLRENRAL------------QPTDSR---ALRLQDLLAMCEDVVRGCRYLEELHFVHRDLACRNCLVSARDRENRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGIFTSQSDVWAFGVLIWEITSLGQ-QPYPARTNLEVLHYVRAGGRLPKPLNCPATLHQLMMRCWD-TADARPSFKICLENIVAL 2091
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|1316174817|ref|XP_023232900.1| (proto-oncogene tyrosine-protein kinase ROS-like [Centruroides sculpturatus]) HSP 1 Score: 389.037 bits (998), Expect = 7.561e-106 Identity = 465/1914 (24.29%), Postives = 813/1914 (42.48%), Query Frame = 0
Query: 10 DLQLDSVNGNVFWHTGNEIWTVSKCDPSSSKRIVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNANVLHQLMGDNRSGHFQSSFKEDIDLRTSVFH-----HPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAEETN---LVTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSLPEG--PTDLVLTWIRKGQVFQSDLLGTNHSRVELPFKARHVACRSGDAV---------LLSTDTSLLSAQGQILFKANAEISGLLFEPFSESVYTMVPK--SDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFFTRKDG------SQTVIHQMDLEDLSIPVQVVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGG----RITDLCVQGAPRQMVPQDLDITPLTVDLDSLKLE---EDSKLVWRALT----GEVTYHLLIQ----VHGR------------QYALQTT---TSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQIS---------SPPQHLRAFHNAVNSSII-------VRWNPPKLPNGHITGYQMEI----NSLDTIIVHPDTLEQVLVE------LPSQQLHIDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRRIRATYDVGAIQTLDFQGPKAV--FSQGGSIFALNLINHVRERVLTQAEL------ILH--------LRVDWISNCIFFVAVSGSDY-SIRRFSVDSG----VLSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLE---------LSLFGRIKSLKPTSTHAQ------CSCFQMDPRSPFYFTL-RPNIPEQKASLTLLTHDGSLFATD-NGCECQLMRK--------IPAWSQLSSDGSNLYWKSHEFVQYLNLQEG------------------QISHFNGSSRNEGVI-IRPFCPDCQMTPIKQCLVPSLVEQRV-TILEAGEDWLRVSLP--QFRAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPE-SCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQKPTEKEFSVELKDLEPGEIYKIWVEA-RTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQ-AFQFRLVPLKSNLNASQYQWPMELSSIQPGHQ-YQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWNSNNDLVES--FELQARIHDSNVTVEDNVTMSNWSVVYADTSPQWPISGL-SDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIV----------GIIGVLVVVV------LIIFLRRPWDKKSALGIQR-----HRELELATIHELPVMLNGGMES-NPTYGVQIPSEQEMEDIPKL-------KRNQITLVNFIGCGAFGQVQCRDPRRLLK--LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQELLVYEDELAEIPSFCQFNPTSHPNSVSMHN 1731
DL +D +G VF ++I ++ + + I+ L + ID+ + R+L+ + + ++ L D +++ + F ++ L ++N+ +YWT ++ G+ ++ ++ + H + QP PVPLN V V+ F A++ W N WQ+W Y+I L +F N + + T ++ +RA S GGK EWS ++L + P + W + + +SD++G N + K + + +L D + N+ I+ + + + P+ + EI R + E L I K L +DS L W S+ S+L G + ++ ++S + L ++ ++++T ++ S + + + ++++ L + G L Y+ D+L WI + + + D+ G++ + G I D +Q P + D+++ P ++ + +E + +VW ++T G++ Y + + ++G +++L+ + +A E + AA+ +KS + P +S S P++ R F +S + RW+PP NG + GYQ+ + T + H T++ +++ LP+ + N G+ S ++ + +P++L+ ++ ++ DLD A + + + ++ P AV ++ IF L+ + R L + + ++H L +DWI +++ + Y SI + + S + N + T D I E++P T L ++ + K+ L + + SL S K Q CS R+ FT+ R NI + L + +DG ++A+D NGC C+++ +P + +++D + +YW ++E ++ + Q F +GV I Q P +CL PS E + +L++ + L++ LP CT+ SLP ++TIYY SE+ +C + S C+ ++ ++ L+PFT Y I +++ ++ I QT +G P P+N+ + PE ++V W P NGK + Y+V +++ + + H +K EK ++LK+L PG Y I V A +G S E+ A+T+ + + + ++ F W SP IQ + + +P + W L Y I++L P T+Y ++ VLT+ + +Y+WP+D+ +I+ ET +P IPG PYV + V + W E+ + L+++I ED S W +VY T QW L Y FRV+A N++G S FS + P + L+S L +G + + A I+ GI+G + V + +I+ L D + L R L L + + V + G + + V S + E I +L N I L G ++ P L L DL IC DVAKGC L +M ++HRD+AARNCLVSS D R+VKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T +SDVW+FGVLLWE+M LG+ PYP NL+V+ +V GG P NCP+ L LM+ CW+++P+ RPTF CL +++EL + I S N H ++ + N
Sbjct: 345 DLHVDPFHGFVFLVDLHDI-SLKPAFENDIQLIIKDYNLETFTIDYMNFRILIPNATLNTIIATSL---DGTDSIDIRYNSHSPHFSNVKS--LTYHNNLFYWTTGTSIY---GEEYHSKVDKYYRNKFLIKANYISNVKVLHIDSQPYPVPLNEVENVQALFQ------DETAKIFWSKPKLLNDVGKGAWQKWFYEIHLFDHVKNLTIFGNRTANNIYKIFTLRPNTTYSIKIRACSLGGKGEWSSEFVGKTLMQNNSPGYPYIIWSSREGIIKSDIIGENVEPLIYNIKLDEIGVTVKGELTDINVIPDSILEKDIWVEGMWNNFTIVWNS-ITNVNYGDIFYEIKLNGPEDINGEISRANLDGTQPESLSINTLAEK-LVIDSPSGHLYW-STTHSVEGSNLNGDNTYTYMQTGVFSGKRVMGLTLNYDQQKIYWTIRNYEGSWLYSAKTLKNVFGRNKDDVIELIAQLPENAIQGPLWYFSDRLFWINEEKEALISDMSGRNVACFKHVGLKDLETLTIIDPALQPYPMKGELTDINVIPDSILEKDIWVEGMWNNFTIVWNSITNVNYGDIFYEIKLNGPEDINGEDPVEWRLFIDLLKFSLKGVLPYNGNKHSSVPVAHAVHIKETYNNMKAAAEHNKSWVICDAQQLPKCLSTDAVNVLNPSSPENPRIFIMYKSSFLFPNDIEAEFRWSPPLHINGILLGYQINCWHMKENKSTSLCHNVTVDGSILKYKLKNLLPNCTYSFQVAAYNVIGIGTFSDIVKTHTSQENPIPKLLL---VKTDTVEMTDLDT----AEEHLLSNKIIE---PVAVTYLAKDDKIFWLD-----KNRALMSSHMDGSNTALIHSLSSPGTSLTIDWIGRYLYWAEHENNYYDSIWKLDITSSQAPHFILNYSSTIDSI---EVEPFTRKLIWSAMKQDKYNLMRSDTNGQNIENFFSLSNNCHSSKSDIQRNQIGHSYNCSSSLFVRRA---FTIDRSNISHPEL-LWVDGNDGHIWASDLNGCNCRILVNANENKNIGLPP-TSITADTTAIYWFNNESGGIYSMNKNSKFQNPPTPPPKLPTSASQKRRFQLIKEIQGVKQIYAIGSHLQSYPDIKCLYPS--ESGIPQLLDSSFNSLKLQLPLISHSKDCTDISLPTFQYTIYY--------SEVNKFNKIINCEFNISHCIIMKT-------YDDIIVLTGLKPFTTYMIQVAINNYY-NKGNITLGPTVTYQTKEGVPSAPDNIIVVPVSPEQLDVYWNPSIRFNGKSVSYEVRWKVDYSGDQFNLDT-HARKAHEKCM-MKLKNLLPGTKYYIVVRAYSSGEDLYNDSQEVTAKTYDQPNNLTLLETNEENLKFSWLSPSDGVIQHSLEITELP--------DFNWHEVLKQETSEETVYNFTIENLYPRTKYSVRLVLTYV--ENNVSYVWPKDT-QIIYETLGKSPNIPGIPYV-QNVGRDLYQVVWTEPFPFDENTIYHLESKIFK-----EDESDYSQWKLVYNGTVNQWLTENLLPKFYYQFRVQAINDYGESNFSNASQPF---MALNSIALANQTNGQITVILASILPTLFFIASSLGIVGYIRVCLNNNPNFIILELMEGGDLLTYLRSHRPSIFTSNPLNLEDLLSICVDVAKGCKCLEEMHFVHSFSNFKHEHILQLLGVCLNNNPNFIILELMEGGDLLTYLRSHRPSIFTSNPLNLEDLLSICVDVAKGCKCLEEMHFVHRDLAARNCLVSSHDPFTRIVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTNQSDVWAFGVLLWEVMTLGQ-QPYPARTNLEVLHYVRIGGQLDKPQNCPDDLHQLMVMCWSYYPENRPTFDYCLEKLKELHRKSTSASHIDSVHNHNYLGHIHNGGIEN 2176
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|1008429184|ref|XP_015840704.1| (PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum]) HSP 1 Score: 330.872 bits (847), Expect = 1.038e-87 Identity = 393/1633 (24.07%), Postives = 687/1633 (42.07%), Query Frame = 0
Query: 10 DLQLDSVNGNVFWHT-GNEIWTVSKCDPSSSKR-------IVHRAKLG--SMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGI--LFHYNDSYYWTNANVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEI-----QPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAEETNL----VTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSLPEGPTDLVLTWIRKGQVFQSDLLGTN------HSRV------ELPFKARHVACRSGDAVLLSTDTSLLSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFFTRKDGSQTVIHQMDLEDLSIPVQ---VVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGGRITDLCVQGAPRQMVPQ--DLDITPLTVDLDSLKL---EEDSKLVWRALT----GEVTYHLLIQVHGRQ-YALQTTTSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF----HNAVNSSIIVRWNPPKLPNGHITGYQMEINSLDT---------IIVHPDTLEQVLVELPSQQLH-IDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRR----IRATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVLTQAELILHLRVDWISNCIFFVAVSGSDYSIRRFS-----VDSGV--LSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELS----LFGRIKSLKPTSTHAQCSCFQMDPRSPFYFTLRPNIPEQKASLTLLTHD--GSLFATDNGCECQLMRK------IPAWSQLSSDGSNLYWKSHEFVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVP-SLVEQRVTILEAGEDWLRVSLPQFRAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQK----------PTEKEFSVELKDLEPGEIYKIWVEARTGSSKV-AQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAW----NSNNDLVESFELQA-RIHDSNVTVEDNVTM------------SNWSVVYADTSPQWPISGLSDA-AYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKS--ALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
++++D NG +FW G ++ + D S+ R I+ KL + +D + RL V + + ++ V D +I+N+ R +S E + L N +YWTN + + N S +F +S+ D+ L T + I QPIP P+NP V+ FG+N +A+ W P WQ W+Y++ ++ + ++K N ++ + T + A + G+ WS +L ++ W + ++D G N SR+ ++ + V + D+ + DT S QGQ++ + + + + +Y PK I+R + +E L I K L++DS+ A L W G ++ C+ L G + + L+S + L +D +++ + + + + + S + +T L+ G L Y+H +L W+QD DL G + +TI G +T + V + ++P ++ + P TVD +S+++ + W + G+V Y + I R A+ T ++ + Q++A P T+++V + A + W SPQ+ +++P S P +LRA+ + N +I VRW PP PNG + GY++ L+ ++ P+ Q+ + P ++ +++ + G S + N LP++L+ + D+D R + I L + Q ++ +++ + ++ + + + VDW+ I++ D F VD G+ +S V T I +E+ P T LY+ + K + + S F + K K ++ C+C +D +TL + E K L + D + A NGC C ++ +P +L SD LYW + + L +E + + R+ I F P Q P +CL P L RVT+ E L + +P+ C + S+P VE+ IYY I +C L + +F IK L+PFT Y + +++ ++ I + QT G P PP+NVT L+P +V+W PP+ NG VHYE++ T R SG RQK P ++ L L P E Y IWV+A + +++ + S +++ T+ S + RT +T W I + ++ P+ SN W + + G ++L P TQY + L++ YIWPQDS R + ET D P PG P + + + +Y W N +E ++L+ + + N T W Y T W I+GLS+ Y FRV A N +GWS S+ + ++ +++ + + TLI ++ I + V ++++L I R+ K + I R ++ELAT+ ELP G +N Y P+ +EM +P ++R+QITL+ F+G GAFG+V
Sbjct: 464 NIEVDPYNGYLFWGIHGTGLYRLDISDFSNGIRHEVQPVLILSEKKLNMSAFTVDHTNFRLFVANEREK---TINTVSLDGKEIINV----RPNVIKSKLENVVSLATANKKFYWTNGDDIFYEEYHN-SVYFHNSYP-DLSLSTKSYKKVIINLQSSQPIPSPVNPPTNVQAIFGSN------IAKTTWLPPHLLGIQGKGAWQNWSYEVAIK-EVGSQKFISHRNINTTSYKISGLRENTEYVIKAAAYTRSGQGPWSSEFRGFTLSRSKNPMIY-WSAAKGLLRTDAAGENVETLIHKSRIKGSVFIDMTWYQDLVYLVTNDSHVYWYDTRSHS-QGQLI--GIDSVGSIAVDWIGKKLYWSNPKRQMIIRGNLNGTQQEPLPILTLA-KELNIDSVKAYLYW-STGFAVRCAHLNGENLIEYHPVQLFSGRQVMGLTLDMHNKFVYWIVRGLEGSNLFRAPMAGYSEKITENFKITSLQKPNMQGPLCYFHKRLLWLQDNKNAAISDLQGNNIATIS-GKSMSDLTLVYVVDSSLHVMPDIPEIVVIPETVDKNSVRVIGSLNSFNVTWNPVKNVNYGQVFYEVSIDSLLRNDSAIVTNSTSVRYWQQVA---PFTKLQVAIRAFTYWGTSPQIRAKVYSPASTPSVPTNLRAYVTHHSSGTNVTITVRWGPPLFPNGVLKGYKIHCWYLNAAQRRDVCRDLVKKPEEF-QIDFKPPHDHIYYFNVQAFSEMGDGDLSDPIQVNSSQELPLPRLLV---ASEDSIFIQDIDSDRNESLLHGIVTPTEIGYLIKESKLFWIDQLQNLMMYDMLKGNKTKITSLRNNVTGVTVDWLERSIYYAQSENWDSGSSVFKLDLNYVDRGIVKMSKVFFTPASISKIEVSPYTRKLYW--VEKSKLMVCNTDGSDKSEFFNKNKYTKRSTLGGGCNC-PVDVNIEKTYTLDHST-ETKPLLVFVESDTQNVVSADKNGCSCSVIANNSLGVTLPL-DRLKSDFGTLYWTNSRLLHALRKKEANLVTKEVNGRD----ILIFGPHMQPFPPSECLRPRQLANIRVTLKEKTATSLTLVMPEVGQICADTSMPTVEYRIYY----------AEKIDNNTCD--------LTCNFSATFDKEFT--IKSLKPFTHYVVAVAVSNYYTEEEEIVLGPSTVFQTAVGAPSPPQNVTVKVLNPTMAQVSWSPPQHPNG----VTVHYEIY--CQTERTLSGVRQKEQSNVEQQFTPNSHFLTIVLNKLSPNETYTIWVKAYSETNETSSDSDKVQINTYPEPSDLILVNRTAYMLTVTWDV--CANIDHYNVQMSPVTSN------DW---RNVSESGEGIFASEENLQPKTQYKFRLSLSYY--NYPEEYIWPQDS-RFVYETLGDKPSPPGTPKI--QYVKPNIYKVWWEEAKDNGAPIELYKLEGLELPNYRTKRSTNRTAFFYTAPSVEEEEREWQQFYNGTETSWIINGLSEKYKYEFRVLALNAYGWSDPSDSSTAFDLN--EAARMAEKQSPMTLIAIATFIP--VSVFLIILLCIVCRKYGKPKKVQVVSIPRGPDVELATLRELP--RRGIHNTNVLYVSTQPTSEEMTLLPHIRRDQITLMKFLGSGAFGEV 2009 HSP 2 Score: 228.409 bits (581), Expect = 4.201e-56 Identity = 103/168 (61.31%), Postives = 129/168 (76.79%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
L+L +L ++C DVAKGC YL +M ++HRD+A RNCLVSS D DR+VKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVLLWEIM LG+ PYP NNL+V+ +V GG P +CPE L NLML+CW F D+RPTF+ CL + L
Sbjct: 2100 LSLIELLKMCVDVAKGCRYLEEMHFVHRDLACRNCLVSSKDP-DRIVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLLWEIMTLGQ-QPYPARNNLEVLHYVRRGGRLGKPTDCPETLHNLMLKCWEFEADKRPTFKYCLDVLDNL 2265
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|1004403084|gb|EEZ99293.2| (sevenless [Tribolium castaneum]) HSP 1 Score: 330.487 bits (846), Expect = 1.088e-87 Identity = 393/1633 (24.07%), Postives = 687/1633 (42.07%), Query Frame = 0
Query: 10 DLQLDSVNGNVFWHT-GNEIWTVSKCDPSSSKR-------IVHRAKLG--SMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGI--LFHYNDSYYWTNANVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEI-----QPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAEETNL----VTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSLPEGPTDLVLTWIRKGQVFQSDLLGTN------HSRV------ELPFKARHVACRSGDAVLLSTDTSLLSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFFTRKDGSQTVIHQMDLEDLSIPVQ---VVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGGRITDLCVQGAPRQMVPQ--DLDITPLTVDLDSLKL---EEDSKLVWRALT----GEVTYHLLIQVHGRQ-YALQTTTSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF----HNAVNSSIIVRWNPPKLPNGHITGYQMEINSLDT---------IIVHPDTLEQVLVELPSQQLH-IDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRR----IRATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVLTQAELILHLRVDWISNCIFFVAVSGSDYSIRRFS-----VDSGV--LSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELS----LFGRIKSLKPTSTHAQCSCFQMDPRSPFYFTLRPNIPEQKASLTLLTHD--GSLFATDNGCECQLMRK------IPAWSQLSSDGSNLYWKSHEFVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVP-SLVEQRVTILEAGEDWLRVSLPQFRAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQK----------PTEKEFSVELKDLEPGEIYKIWVEARTGSSKV-AQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAW----NSNNDLVESFELQA-RIHDSNVTVEDNVTM------------SNWSVVYADTSPQWPISGLSDA-AYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKS--ALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
++++D NG +FW G ++ + D S+ R I+ KL + +D + RL V + + ++ V D +I+N+ R +S E + L N +YWTN + + N S +F +S+ D+ L T + I QPIP P+NP V+ FG+N +A+ W P WQ W+Y++ ++ + ++K N ++ + T + A + G+ WS +L ++ W + ++D G N SR+ ++ + V + D+ + DT S QGQ++ + + + + +Y PK I+R + +E L I K L++DS+ A L W G ++ C+ L G + + L+S + L +D +++ + + + + + S + +T L+ G L Y+H +L W+QD DL G + +TI G +T + V + ++P ++ + P TVD +S+++ + W + G+V Y + I R A+ T ++ + Q++A P T+++V + A + W SPQ+ +++P S P +LRA+ + N +I VRW PP PNG + GY++ L+ ++ P+ Q+ + P ++ +++ + G S + N LP++L+ + D+D R + I L + Q ++ +++ + ++ + + + VDW+ I++ D F VD G+ +S V T I +E+ P T LY+ + K + + S F + K K ++ C+C +D +TL + E K L + D + A NGC C ++ +P +L SD LYW + + L +E + + R+ I F P Q P +CL P L RVT+ E L + +P+ C + S+P VE+ IYY I +C L + +F IK L+PFT Y + +++ ++ I + QT G P PP+NVT L+P +V+W PP+ NG VHYE++ T R SG RQK P ++ L L P E Y IWV+A + +++ + S +++ T+ S + RT +T W I + ++ P+ SN W + + G ++L P TQY + L++ YIWPQDS R + ET D P PG P + + + +Y W N +E ++L+ + + N T W Y T W I+GLS+ Y FRV A N +GWS S+ + ++ +++ + + TLI ++ I + V ++++L I R+ K + I R ++ELAT+ ELP G +N Y P+ +EM +P ++R+QITL+ F+G GAFG+V
Sbjct: 18 NIEVDPYNGYLFWGIHGTGLYRLDISDFSNGIRHEVQPVLILSEKKLNMSAFTVDHTNFRLFVANEREK---TINTVSLDGKEIINV----RPNVIKSKLENVVSLATANKKFYWTNGDDIFYEEYHN-SVYFHNSYP-DLSLSTKSYKKVIINLQSSQPIPSPVNPPTNVQAIFGSN------IAKTTWLPPHLLGIQGKGAWQNWSYEVAIK-EVGSQKFISHRNINTTSYKISGLRENTEYVIKAAAYTRSGQGPWSSEFRGFTLSRSKNPMIY-WSAAKGLLRTDAAGENVETLIHKSRIKGSVFIDMTWYQDLVYLVTNDSHVYWYDTRSHS-QGQLI--GIDSVGSIAVDWIGKKLYWSNPKRQMIIRGNLNGTQQEPLPILTLA-KELNIDSVKAYLYW-STGFAVRCAHLNGENLIEYHPVQLFSGRQVMGLTLDMHNKFVYWIVRGLEGSNLFRAPMAGYSEKITENFKITSLQKPNMQGPLCYFHKRLLWLQDNKNAAISDLQGNNIATIS-GKSMSDLTLVYVVDSSLHVMPDIPEIVVIPETVDKNSVRVIGSLNSFNVTWNPVKNVNYGQVFYEVSIDSLLRNDSAIVTNSTSVRYWQQVA---PFTKLQVAIRAFTYWGTSPQIRAKVYSPASTPSVPTNLRAYVTHHSSGTNVTITVRWGPPLFPNGVLKGYKIHCWYLNAAQRRDVCRDLVKKPEEF-QIDFKPPHDHIYYFNVQAFSEMGDGDLSDPIQVNSSQELPLPRLLV---ASEDSIFIQDIDSDRNESLLHGIVTPTEIGYLIKESKLFWIDQLQNLMMYDMLKGNKTKITSLRNNVTGVTVDWLERSIYYAQSENWDSGSSVFKLDLNYVDRGIVKMSKVFFTPASISKIEVSPYTRKLYW--VEKSKLMVCNTDGSDKSEFFNKNKYTKRSTLGGGCNC-PVDVNIEKTYTLDHST-ETKPLLVFVESDTQNVVSADKNGCSCSVIANNSLGVTLPL-DRLKSDFGTLYWTNSRLLHALRKKEANLVTKEVNGRD----ILIFGPHMQPFPPSECLRPRQLANIRVTLKEKTATSLTLVMPEVGQICADTSMPTVEYRIYY----------AEKIDNNTCD--------LTCNFSATFDKEFT--IKSLKPFTHYVVAVAVSNYYTEEEEIVLGPSTVFQTAVGAPSPPQNVTVKVLNPTMAQVSWSPPQHPNG----VTVHYEIY--CQTERTLSGVRQKEQSNVEQQFTPNSHFLTIVLNKLSPNETYTIWVKAYSETNETSSDSDKVQINTYPEPSDLILVNRTAYMLTVTWDV--CANIDHYNVQMSPVTSN------DW---RNVSESGEGIFASEENLQPKTQYKFRLSLSYY--NYPEEYIWPQDS-RFVYETLGDKPSPPGTPKI--QYVKPNIYKVWWEEAKDNGAPIELYKLEGLELPNYRTKRSTNRTAFFYTAPSVEEEEREWQQFYNGTETSWIINGLSEKYKYEFRVLALNAYGWSDPSDSSTAFDLN--EAARMAEKQSPMTLIAIATFIP--VSVFLIILLCIVCRKYGKPKKVQVVSIPRGPDVELATLRELP--RRGIHNTNVLYVSTQPTSEEMTLLPHIRRDQITLMKFLGSGAFGEV 1563 HSP 2 Score: 229.18 bits (583), Expect = 1.973e-56 Identity = 103/168 (61.31%), Postives = 129/168 (76.79%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
L+L +L ++C DVAKGC YL +M ++HRD+A RNCLVSS D DR+VKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVLLWEIM LG+ PYP NNL+V+ +V GG P +CPE L NLML+CW F D+RPTF+ CL + L
Sbjct: 1654 LSLIELLKMCVDVAKGCRYLEEMHFVHRDLACRNCLVSSKDP-DRIVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLLWEIMTLGQ-QPYPARNNLEVLHYVRRGGRLGKPTDCPETLHNLMLKCWEFEADKRPTFKYCLDVLDNL 1819
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|817083237|ref|XP_012264218.1| (proto-oncogene tyrosine-protein kinase ROS isoform X2 [Athalia rosae]) HSP 1 Score: 330.872 bits (847), Expect = 1.220e-87 Identity = 395/1651 (23.92%), Postives = 711/1651 (43.06%), Query Frame = 0
Query: 11 LQLDSVNGNVFWHTGNEIWTVSKCDPSSSKR-------IVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNA-NVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAE---ETNLVTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSL--PEGPTDLVLTWIRKGQVFQSDLLGTNHSRV---------ELPFKARHVACRSGDAVLLSTDTSL----LSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFF-TRKDGSQTVIHQMDLEDLSIPV------QVVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTI----LLGGRGGRITDLCVQGAPRQMVPQDLDITPLTVDLDSLKLEED-SKL------VWRALTGEVTYHLLIQVHGRQYALQTTTSELDLAQEIAS-LTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF--------HNAVNSSIIVRWNPPKLPNGHITGYQM---------EINSLDTIIVHPDTLE-QVLVELPSQQLHIDLRCQNNAGLSPASTLL-IQNRFVLPSLPQILIYQGIQGGKLD---FYDLDRRRIRATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVL-----TQAELILHLR-------VDWISNCIFFV------AVSGSDYSIRRFSV---DSGV--LSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQ-CSCFQMDPRSPFYFTLRP-----NIPEQKASLTLLTHDGSLFATD-NGCECQLM------RKIPAWSQLSSDGSNLYWKSHE-----FVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQF--RAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLI--KDLEPFTRYGIYLSLQKGKPSQQTIPTELIA--LAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPS----GHRQKPTEKEFSVELKDLEPGEIYKIWVEARTGSSKVA--QSAEIEAQTFSRVSLPEITTRTPRSVTFIWR-SPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWN---SNNDLVESFELQARI-HDSNVTVEDNVTMSNWSVVYADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAG-IVGIIGVLVVVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQVQCRDPRRL 1532
+++D NG +FW + ++ + D S+ + I+ A L + +D + RLLV Q+ ++ + L D ++ NL +Q F+++ L N +YWTN ++L + + +F +S+ + + +V QP PVP+NP V+ G + +A+V W WQ W+Y++ ++ S E + Q E ++ V + + + A + G+ WS +L P+G + + W + +SD+ G N + ++ + VA L+ ++ L +++ N+ + + + S+ +Y PK I R + +E + I A VK L +DSL A L W G ++ S L G R ++++ + L +D +++ R S +V+++ + IP+ + ++ L+HS G L Y+ + L W+QD V DL GQ+ + I L G + I D + P+ + +++ + P V++DS+++ + SK V G V Y + H A T E +A + +P + VT+ A + W S K L +P S P + R F + + SI+ RW+ P PNG I GY + +I D I V P LE +V L + + ++ G + ++ I F P +PQIL+ LD DLDR AI+ ++ IN ++E V+ + A IL L VDWI+ +F+ V GS I R + ++G + + T +++ PL LY+ + + ++ L G ++P HA+ CSC PF +RP N + ++ +G+L D GC C ++ + +P S L+ D N+YW + + F+ LN + +I F+ S ++ Q P +CL+P V V ++E + +++ LP+ C LP +T+Y +E P C + + +V +Q ++ LI K+L+PFT+Y + L ++ EL + +T G P PENV AL P + W+PPKV NG + Y++H+ +++ R + ++P + + S L+ L PG+ Y ++V A + S + +S + + + + +T ++ S+ W + I + ++ +V L+ +W + +S++ + + I++L P T Y Q L R +IWP D+ R ET D P PG P + K+ S ++W ++ + + L+ R+ DSN+ E+ S W++ Y T W G + Y FRV+A+N +G+ ++SE + +++ +S + + + G ++GLS I+G++ + V L ++ +R DKK + ++ELAT+ E+P ++SN Y I ++ + +PK+KR QITL F+G GAFG+V D + L
Sbjct: 465 IEVDPYNGYLFWVRKDGLFRLDLADISNGIKHETHPDLILEDAHLEAFMVDHRNFRLLVPHHVQNTVISVTL---DGREVSNLRANTQQPKFKNVVS--LAMANGLFYWTNGQDILKEDYHPGQDRYFHNSYPDRSCVSVNVLMDAS-QPAPVPVNPPTGVQAVLGAH------MAKVSWRAPYLLGGQGKGAWQNWSYELEIKDVSTGEPIHQEEIGGSSHTVYHLRERSEYLIKAAAYTSAGRGPWSSEFRGCTLRDPKGGSYASILWSASEGLLRSDVTGENVETLIQKSSWKDSDMEYHIIDVAWYKDLLYLVGNNSMLYCYNMTSHETYRLHINS-VRSVAVDWISKKLYWANPKQQIITRANLDGTQQEPMSILAI-VKELMIDSLEAYLYW-STGHAVEVSRLNGQDRRYYHSDEIFNGKQVMGLTLDTENKSVYWIVRSYESGSVLYRAPTSE-RIPMNQEIVPEKLSALQHSNMQGPLCYFSEHLLWLQDDRNAVIGDLSGQNTAVINGITLSGLQMVAIMDHALHQYPKNLSSENITVLPSAVNVDSIRVVGNWSKFNVSWDPVRNTNYGTVFYEVKYADHINTNANPEITKETTIAYNNSERFSPYAILEVTIKAFTYWGMSHHTRKILRSPQAEPSHPTNPRGFVEFNKKPLSDDTDISIVFRWDQPDHPNGLILGYTIVCWYMKDDTKITICDKINVPPKNLEYKVDKVLSNTTYYFKVQAHTIVGAGWFTDVINISTEFEYP-VPQILV------ATLDAVRISDLDRGINDTITRHIAIEVAYSAAENKIY----------WINEMQEMVIADIDSSNATKILALNNSASSLCVDWITRTLFWTESEYRETVVGS--QIMRLDLTAWEAGYTKVEKIITTNRAASKLDISPLMGILYWIESSQNDRGI-IMQSDLHG--DDIQPFFNHAEDCSC-------PFAPLVRPVMAVDNTDIHNPVIYWVSQEGNLNIADIEGCVCNMVLSPDSGKGLPPTS-LTVDKVNVYWSNIDQDQVYFINKLNPDDTEIKKFHLYSARS---LKAIGNSLQPYPFAECLIPRQVSYNVELIEKFANSIKIKLPEPVPHFGCDKFHLPATLYTVYI--------TECLVNDPRDCKN------RERVRVQS-----YEKLIEAKNLKPFTKYMFQVGLSNYYSELESSTLELGPGNIIRTDAGAPTRPENVVVQALTPTLASINWMPPKVLNGAVVRYEIHWRSAQLVNGIRQKGEQLIKNTEQPADGKLSAMLQPLLPGQEYLVYVRAYSAHSTTSYNESVPLSVRMYPEPNNLTLTGQSINSMNVSWAPNESITIVYHLEYSIVGLE--------KWQIATNSVKRNDKVEFIIQNLRPRTLYRFQ--LVLRYPNYNQDFIWPADA-RFTFETSGDVPSAPGIP-ISTKLRGSVHQISWEPAQAHGSQITLYRLEGRVVEDSNLVEENRNDTSQWNLYYNGTDASWISVGEMNQKYQFRVQARNAYGFGKWSEISGVVDLTEAVSGILVARQHLGLVLGLSVPLILGVMLLCFGVFLCLYRQRKEDKKVVIP-PTMPDVELATLREIP--RGNFVQSNALYASAIQNDPDDSALPKIKREQITLAKFLGSGAFGEVFQGDAKDL 2032 HSP 2 Score: 209.92 bits (533), Expect = 1.896e-50 Identity = 96/168 (57.14%), Postives = 123/168 (73.21%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
L L DL +C DVA+GC YL ++ ++HRD+A RNCLVS+ D ++RVVKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVL+WEI +LG+ PYP NL+V+ V GG P NCP L LMLRCW+ D RP+F+ CL + L
Sbjct: 2115 LRLQDLLAMCEDVARGCRYLEELHFVHRDLACRNCLVSARDRENRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQ-QPYPARTNLEVLYHVRAGGRLPKPLNCPTALHQLMLRCWST-ADARPSFKACLDHIITL 2280
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|817083241|ref|XP_012264220.1| (proto-oncogene tyrosine-protein kinase ROS isoform X4 [Athalia rosae]) HSP 1 Score: 327.02 bits (837), Expect = 1.976e-86 Identity = 395/1654 (23.88%), Postives = 712/1654 (43.05%), Query Frame = 0
Query: 11 LQLDSVNGNVFWHTGNEIWTVSKCDPSSSKR-------IVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNA-NVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAE---ETNLVTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSL--PEGPTDLVLTWIRKGQVFQSDLLGTNHSRV---------ELPFKARHVACRSGDAVLLSTDTSL----LSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFF-TRKDGSQTVIHQMDLEDLSIPV------QVVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTI----LLGGRGGRITDLCVQGAPRQMVPQDLDITPLTVDLDSLKLEED-SKL------VWRALTGEVTYHLLIQVHGRQYALQTTTSELDLAQEIAS-LTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF--------HNAVNSSIIVRWNPPKLPNGHITGYQM---------EINSLDTIIVHPDTLE-QVLVELPSQQLHIDLRCQNNAGLSPASTLL-IQNRFVLPSLPQILIYQGIQGGKLD---FYDLDRRRIRATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVL-----TQAELILHLR-------VDWISNCIFFV------AVSGSDYSIRRFSV---DSGV--LSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQ-CSCFQMDPRSPFYFTLRP-----NIPEQKASLTLLTHDGSLFATD-NGCECQLM------RKIPAWSQLSSDGSNLYWKSHE-----FVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQF--RAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLI--KDLEPFTRYGIYLSLQKGKPSQQTIPTELIA--LAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPS----GHRQKPTEKEFSVELKDLEPGEIYKIWVEARTGSSKVA--QSAEIEAQTFSRVSLPEITTRTPRSVTFIWR-SPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWN---SNNDLVESFELQARI-HDSNVTVEDNVTMSNWSVVYADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLV----VVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQVQCRDPRRL 1532
+++D NG +FW + ++ + D S+ + I+ A L + +D + RLLV Q+ ++ + L D ++ NL +Q F+++ L N +YWTN ++L + + +F +S+ + + +V QP PVP+NP V+ G + +A+V W WQ W+Y++ ++ S E + Q E ++ V + + + A + G+ WS +L P+G + + W + +SD+ G N + ++ + VA L+ ++ L +++ N+ + + + S+ +Y PK I R + +E + I A VK L +DSL A L W G ++ S L G R ++++ + L +D +++ R S +V+++ + IP+ + ++ L+HS G L Y+ + L W+QD V DL GQ+ + I L G + I D + P+ + +++ + P V++DS+++ + SK V G V Y + H A T E +A + +P + VT+ A + W S K L +P S P + R F + + SI+ RW+ P PNG I GY + +I D I V P LE +V L + + ++ G + ++ I F P +PQIL+ LD DLDR AI+ ++ IN ++E V+ + A IL L VDWI+ +F+ V GS I R + ++G + + T +++ PL LY+ + + ++ L G ++P HA+ CSC PF +RP N + ++ +G+L D GC C ++ + +P S L+ D N+YW + + F+ LN + +I F+ S ++ Q P +CL+P V V ++E + +++ LP+ C LP +T+Y +E P C + + +V +Q ++ LI K+L+PFT+Y + L ++ EL + +T G P PENV AL P + W+PPKV NG + Y++H+ +++ R + ++P + + S L+ L PG+ Y ++V A + S + +S + + + + +T ++ S+ W + I + ++ +V L+ +W + +S++ + + I++L P T Y Q L R +IWP D+ R ET D P PG P + K+ S ++W ++ + + L+ R+ DSN+ E+ S W++ Y T W G + Y FRV+A+N +G+ ++SE + +++ +S + + + G ++GLS + I+GV++ V + ++ +R DKK + ++ELAT+ E+P ++SN Y I ++ + +PK+KR QITL F+G GAFG+V D + L
Sbjct: 422 IEVDPYNGYLFWVRKDGLFRLDLADISNGIKHETHPDLILEDAHLEAFMVDHRNFRLLVPHHVQNTVISVTL---DGREVSNLRANTQQPKFKNVVS--LAMANGLFYWTNGQDILKEDYHPGQDRYFHNSYPDRSCVSVNVLMDAS-QPAPVPVNPPTGVQAVLGAH------MAKVSWRAPYLLGGQGKGAWQNWSYELEIKDVSTGEPIHQEEIGGSSHTVYHLRERSEYLIKAAAYTSAGRGPWSSEFRGCTLRDPKGGSYASILWSASEGLLRSDVTGENVETLIQKSSWKDSDMEYHIIDVAWYKDLLYLVGNNSMLYCYNMTSHETYRLHINS-VRSVAVDWISKKLYWANPKQQIITRANLDGTQQEPMSILAI-VKELMIDSLEAYLYW-STGHAVEVSRLNGQDRRYYHSDEIFNGKQVMGLTLDTENKSVYWIVRSYESGSVLYRAPTSE-RIPMNQEIVPEKLSALQHSNMQGPLCYFSEHLLWLQDDRNAVIGDLSGQNTAVINGITLSGLQMVAIMDHALHQYPKNLSSENITVLPSAVNVDSIRVVGNWSKFNVSWDPVRNTNYGTVFYEVKYADHINTNANPEITKETTIAYNNSERFSPYAILEVTIKAFTYWGMSHHTRKILRSPQAEPSHPTNPRGFVEFNKKPLSDDTDISIVFRWDQPDHPNGLILGYTIVCWYMKDDTKITICDKINVPPKNLEYKVDKVLSNTTYYFKVQAHTIVGAGWFTDVINISTEFEYP-VPQILV------ATLDAVRISDLDRGINDTITRHIAIEVAYSAAENKIY----------WINEMQEMVIADIDSSNATKILALNNSASSLCVDWITRTLFWTESEYRETVVGS--QIMRLDLTAWEAGYTKVEKIITTNRAASKLDISPLMGILYWIESSQNDRGI-IMQSDLHG--DDIQPFFNHAEDCSC-------PFAPLVRPVMAVDNTDIHNPVIYWVSQEGNLNIADIEGCVCNMVLSPDSGKGLPPTS-LTVDKVNVYWSNIDQDQVYFINKLNPDDTEIKKFHLYSARS---LKAIGNSLQPYPFAECLIPRQVSYNVELIEKFANSIKIKLPEPVPHFGCDKFHLPATLYTVYI--------TECLVNDPRDCKN------RERVRVQS-----YEKLIEAKNLKPFTKYMFQVGLSNYYSELESSTLELGPGNIIRTDAGAPTRPENVVVQALTPTLASINWMPPKVLNGAVVRYEIHWRSAQLVNGIRQKGEQLIKNTEQPADGKLSAMLQPLLPGQEYLVYVRAYSAHSTTSYNESVPLSVRMYPEPNNLTLTGQSINSMNVSWAPNESITIVYHLEYSIVGLE--------KWQIATNSVKRNDKVEFIIQNLRPRTLYRFQ--LVLRYPNYNQDFIWPADA-RFTFETSGDVPSAPGIP-ISTKLRGSVHQISWEPAQAHGSQITLYRLEGRVVEDSNLVEENRNDTSQWNLYYNGTDASWISVGEMNQKYQFRVQARNAYGFGKWSEISGVVDLTEAVSGILVARQHLGLVLGLSVPL--ILGVMLLCFGVFLCPVYRQRKEDKKVVIP-PTMPDVELATLREIP--RGNFVQSNALYASAIQNDPDDSALPKIKREQITLAKFLGSGAFGEVFQGDAKDL 1990 HSP 2 Score: 209.534 bits (532), Expect = 2.061e-50 Identity = 95/165 (57.58%), Postives = 122/165 (73.94%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEV 1699
L L DL +C DVA+GC YL ++ ++HRD+A RNCLVS+ D ++RVVKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVL+WEI +LG+ PYP NL+V+ V GG P NCP L LMLRCW+ D RP+F+ CL +
Sbjct: 2073 LRLQDLLAMCEDVARGCRYLEELHFVHRDLACRNCLVSARDRENRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQ-QPYPARTNLEVLYHVRAGGRLPKPLNCPTALHQLMLRCWST-ADARPSFKACLDHI 2235
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|817083235|ref|XP_012264217.1| (proto-oncogene tyrosine-protein kinase ROS isoform X1 [Athalia rosae]) HSP 1 Score: 327.02 bits (837), Expect = 2.143e-86 Identity = 395/1654 (23.88%), Postives = 712/1654 (43.05%), Query Frame = 0
Query: 11 LQLDSVNGNVFWHTGNEIWTVSKCDPSSSKR-------IVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNA-NVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAE---ETNLVTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSL--PEGPTDLVLTWIRKGQVFQSDLLGTNHSRV---------ELPFKARHVACRSGDAVLLSTDTSL----LSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFF-TRKDGSQTVIHQMDLEDLSIPV------QVVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTI----LLGGRGGRITDLCVQGAPRQMVPQDLDITPLTVDLDSLKLEED-SKL------VWRALTGEVTYHLLIQVHGRQYALQTTTSELDLAQEIAS-LTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF--------HNAVNSSIIVRWNPPKLPNGHITGYQM---------EINSLDTIIVHPDTLE-QVLVELPSQQLHIDLRCQNNAGLSPASTLL-IQNRFVLPSLPQILIYQGIQGGKLD---FYDLDRRRIRATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVL-----TQAELILHLR-------VDWISNCIFFV------AVSGSDYSIRRFSV---DSGV--LSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQ-CSCFQMDPRSPFYFTLRP-----NIPEQKASLTLLTHDGSLFATD-NGCECQLM------RKIPAWSQLSSDGSNLYWKSHE-----FVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQF--RAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLI--KDLEPFTRYGIYLSLQKGKPSQQTIPTELIA--LAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPS----GHRQKPTEKEFSVELKDLEPGEIYKIWVEARTGSSKVA--QSAEIEAQTFSRVSLPEITTRTPRSVTFIWR-SPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWN---SNNDLVESFELQARI-HDSNVTVEDNVTMSNWSVVYADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLV----VVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQVQCRDPRRL 1532
+++D NG +FW + ++ + D S+ + I+ A L + +D + RLLV Q+ ++ + L D ++ NL +Q F+++ L N +YWTN ++L + + +F +S+ + + +V QP PVP+NP V+ G + +A+V W WQ W+Y++ ++ S E + Q E ++ V + + + A + G+ WS +L P+G + + W + +SD+ G N + ++ + VA L+ ++ L +++ N+ + + + S+ +Y PK I R + +E + I A VK L +DSL A L W G ++ S L G R ++++ + L +D +++ R S +V+++ + IP+ + ++ L+HS G L Y+ + L W+QD V DL GQ+ + I L G + I D + P+ + +++ + P V++DS+++ + SK V G V Y + H A T E +A + +P + VT+ A + W S K L +P S P + R F + + SI+ RW+ P PNG I GY + +I D I V P LE +V L + + ++ G + ++ I F P +PQIL+ LD DLDR AI+ ++ IN ++E V+ + A IL L VDWI+ +F+ V GS I R + ++G + + T +++ PL LY+ + + ++ L G ++P HA+ CSC PF +RP N + ++ +G+L D GC C ++ + +P S L+ D N+YW + + F+ LN + +I F+ S ++ Q P +CL+P V V ++E + +++ LP+ C LP +T+Y +E P C + + +V +Q ++ LI K+L+PFT+Y + L ++ EL + +T G P PENV AL P + W+PPKV NG + Y++H+ +++ R + ++P + + S L+ L PG+ Y ++V A + S + +S + + + + +T ++ S+ W + I + ++ +V L+ +W + +S++ + + I++L P T Y Q L R +IWP D+ R ET D P PG P + K+ S ++W ++ + + L+ R+ DSN+ E+ S W++ Y T W G + Y FRV+A+N +G+ ++SE + +++ +S + + + G ++GLS + I+GV++ V + ++ +R DKK + ++ELAT+ E+P ++SN Y I ++ + +PK+KR QITL F+G GAFG+V D + L
Sbjct: 465 IEVDPYNGYLFWVRKDGLFRLDLADISNGIKHETHPDLILEDAHLEAFMVDHRNFRLLVPHHVQNTVISVTL---DGREVSNLRANTQQPKFKNVVS--LAMANGLFYWTNGQDILKEDYHPGQDRYFHNSYPDRSCVSVNVLMDAS-QPAPVPVNPPTGVQAVLGAH------MAKVSWRAPYLLGGQGKGAWQNWSYELEIKDVSTGEPIHQEEIGGSSHTVYHLRERSEYLIKAAAYTSAGRGPWSSEFRGCTLRDPKGGSYASILWSASEGLLRSDVTGENVETLIQKSSWKDSDMEYHIIDVAWYKDLLYLVGNNSMLYCYNMTSHETYRLHINS-VRSVAVDWISKKLYWANPKQQIITRANLDGTQQEPMSILAI-VKELMIDSLEAYLYW-STGHAVEVSRLNGQDRRYYHSDEIFNGKQVMGLTLDTENKSVYWIVRSYESGSVLYRAPTSE-RIPMNQEIVPEKLSALQHSNMQGPLCYFSEHLLWLQDDRNAVIGDLSGQNTAVINGITLSGLQMVAIMDHALHQYPKNLSSENITVLPSAVNVDSIRVVGNWSKFNVSWDPVRNTNYGTVFYEVKYADHINTNANPEITKETTIAYNNSERFSPYAILEVTIKAFTYWGMSHHTRKILRSPQAEPSHPTNPRGFVEFNKKPLSDDTDISIVFRWDQPDHPNGLILGYTIVCWYMKDDTKITICDKINVPPKNLEYKVDKVLSNTTYYFKVQAHTIVGAGWFTDVINISTEFEYP-VPQILV------ATLDAVRISDLDRGINDTITRHIAIEVAYSAAENKIY----------WINEMQEMVIADIDSSNATKILALNNSASSLCVDWITRTLFWTESEYRETVVGS--QIMRLDLTAWEAGYTKVEKIITTNRAASKLDISPLMGILYWIESSQNDRGI-IMQSDLHG--DDIQPFFNHAEDCSC-------PFAPLVRPVMAVDNTDIHNPVIYWVSQEGNLNIADIEGCVCNMVLSPDSGKGLPPTS-LTVDKVNVYWSNIDQDQVYFINKLNPDDTEIKKFHLYSARS---LKAIGNSLQPYPFAECLIPRQVSYNVELIEKFANSIKIKLPEPVPHFGCDKFHLPATLYTVYI--------TECLVNDPRDCKN------RERVRVQS-----YEKLIEAKNLKPFTKYMFQVGLSNYYSELESSTLELGPGNIIRTDAGAPTRPENVVVQALTPTLASINWMPPKVLNGAVVRYEIHWRSAQLVNGIRQKGEQLIKNTEQPADGKLSAMLQPLLPGQEYLVYVRAYSAHSTTSYNESVPLSVRMYPEPNNLTLTGQSINSMNVSWAPNESITIVYHLEYSIVGLE--------KWQIATNSVKRNDKVEFIIQNLRPRTLYRFQ--LVLRYPNYNQDFIWPADA-RFTFETSGDVPSAPGIP-ISTKLRGSVHQISWEPAQAHGSQITLYRLEGRVVEDSNLVEENRNDTSQWNLYYNGTDASWISVGEMNQKYQFRVQARNAYGFGKWSEISGVVDLTEAVSGILVARQHLGLVLGLSVPL--ILGVMLLCFGVFLCPVYRQRKEDKKVVIP-PTMPDVELATLREIP--RGNFVQSNALYASAIQNDPDDSALPKIKREQITLAKFLGSGAFGEVFQGDAKDL 2033 HSP 2 Score: 209.534 bits (532), Expect = 2.116e-50 Identity = 96/168 (57.14%), Postives = 123/168 (73.21%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
L L DL +C DVA+GC YL ++ ++HRD+A RNCLVS+ D ++RVVKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVL+WEI +LG+ PYP NL+V+ V GG P NCP L LMLRCW+ D RP+F+ CL + L
Sbjct: 2116 LRLQDLLAMCEDVARGCRYLEELHFVHRDLACRNCLVSARDRENRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQ-QPYPARTNLEVLYHVRAGGRLPKPLNCPTALHQLMLRCWST-ADARPSFKACLDHIITL 2281
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|817083239|ref|XP_012264219.1| (proto-oncogene tyrosine-protein kinase ROS isoform X3 [Athalia rosae]) HSP 1 Score: 326.25 bits (835), Expect = 3.294e-86 Identity = 395/1654 (23.88%), Postives = 712/1654 (43.05%), Query Frame = 0
Query: 11 LQLDSVNGNVFWHTGNEIWTVSKCDPSSSKR-------IVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNA-NVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAE---ETNLVTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSL--PEGPTDLVLTWIRKGQVFQSDLLGTNHSRV---------ELPFKARHVACRSGDAVLLSTDTSL----LSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFF-TRKDGSQTVIHQMDLEDLSIPV------QVVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTI----LLGGRGGRITDLCVQGAPRQMVPQDLDITPLTVDLDSLKLEED-SKL------VWRALTGEVTYHLLIQVHGRQYALQTTTSELDLAQEIAS-LTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF--------HNAVNSSIIVRWNPPKLPNGHITGYQM---------EINSLDTIIVHPDTLE-QVLVELPSQQLHIDLRCQNNAGLSPASTLL-IQNRFVLPSLPQILIYQGIQGGKLD---FYDLDRRRIRATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVL-----TQAELILHLR-------VDWISNCIFFV------AVSGSDYSIRRFSV---DSGV--LSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQ-CSCFQMDPRSPFYFTLRP-----NIPEQKASLTLLTHDGSLFATD-NGCECQLM------RKIPAWSQLSSDGSNLYWKSHE-----FVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQF--RAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLI--KDLEPFTRYGIYLSLQKGKPSQQTIPTELIA--LAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPS----GHRQKPTEKEFSVELKDLEPGEIYKIWVEARTGSSKVA--QSAEIEAQTFSRVSLPEITTRTPRSVTFIWR-SPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAWN---SNNDLVESFELQARI-HDSNVTVEDNVTMSNWSVVYADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLV----VVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQVQCRDPRRL 1532
+++D NG +FW + ++ + D S+ + I+ A L + +D + RLLV Q+ ++ + L D ++ NL +Q F+++ L N +YWTN ++L + + +F +S+ + + +V QP PVP+NP V+ G + +A+V W WQ W+Y++ ++ S E + Q E ++ V + + + A + G+ WS +L P+G + + W + +SD+ G N + ++ + VA L+ ++ L +++ N+ + + + S+ +Y PK I R + +E + I A VK L +DSL A L W G ++ S L G R ++++ + L +D +++ R S +V+++ + IP+ + ++ L+HS G L Y+ + L W+QD V DL GQ+ + I L G + I D + P+ + +++ + P V++DS+++ + SK V G V Y + H A T E +A + +P + VT+ A + W S K L +P S P + R F + + SI+ RW+ P PNG I GY + +I D I V P LE +V L + + ++ G + ++ I F P +PQIL+ LD DLDR AI+ ++ IN ++E V+ + A IL L VDWI+ +F+ V GS I R + ++G + + T +++ PL LY+ + + ++ L G ++P HA+ CSC PF +RP N + ++ +G+L D GC C ++ + +P S L+ D N+YW + + F+ LN + +I F+ S ++ Q P +CL+P V V ++E + +++ LP+ C LP +T+Y +E P C + + +V +Q ++ LI K+L+PFT+Y + L ++ EL + +T G P PENV AL P + W+PPKV NG + Y++H+ +++ R + ++P + + S L+ L PG+ Y ++V A + S + +S + + + + +T ++ S+ W + I + ++ +V L+ +W + +S++ + + I++L P T Y Q L R +IWP D+ R ET D P PG P + K+ S ++W ++ + + L+ R+ DSN+ E+ S W++ Y T W G + Y FRV+A+N +G+ ++SE + +++ +S + + + G ++GLS + I+GV++ V + ++ +R DKK + ++ELAT+ E+P ++SN Y I ++ + +PK+KR QITL F+G GAFG+V D + L
Sbjct: 465 IEVDPYNGYLFWVRKDGLFRLDLADISNGIKHETHPDLILEDAHLEAFMVDHRNFRLLVPHHVQNTVISVTL---DGREVSNLRANTQQPKFKNVVS--LAMANGLFYWTNGQDILKEDYHPGQDRYFHNSYPDRSCVSVNVLMDAS-QPAPVPVNPPTGVQAVLGAH------MAKVSWRAPYLLGGQGKGAWQNWSYELEIKDVSTGEPIHQEEIGGSSHTVYHLRERSEYLIKAAAYTSAGRGPWSSEFRGCTLRDPKGGSYASILWSASEGLLRSDVTGENVETLIQKSSWKDSDMEYHIIDVAWYKDLLYLVGNNSMLYCYNMTSHETYRLHINS-VRSVAVDWISKKLYWANPKQQIITRANLDGTQQEPMSILAI-VKELMIDSLEAYLYW-STGHAVEVSRLNGQDRRYYHSDEIFNGKQVMGLTLDTENKSVYWIVRSYESGSVLYRAPTSE-RIPMNQEIVPEKLSALQHSNMQGPLCYFSEHLLWLQDDRNAVIGDLSGQNTAVINGITLSGLQMVAIMDHALHQYPKNLSSENITVLPSAVNVDSIRVVGNWSKFNVSWDPVRNTNYGTVFYEVKYADHINTNANPEITKETTIAYNNSERFSPYAILEVTIKAFTYWGMSHHTRKILRSPQAEPSHPTNPRGFVEFNKKPLSDDTDISIVFRWDQPDHPNGLILGYTIVCWYMKDDTKITICDKINVPPKNLEYKVDKVLSNTTYYFKVQAHTIVGAGWFTDVINISTEFEYP-VPQILV------ATLDAVRISDLDRGINDTITRHIAIEVAYSAAENKIY----------WINEMQEMVIADIDSSNATKILALNNSASSLCVDWITRTLFWTESEYRETVVGS--QIMRLDLTAWEAGYTKVEKIITTNRAASKLDISPLMGILYWIESSQNDRGI-IMQSDLHG--DDIQPFFNHAEDCSC-------PFAPLVRPVMAVDNTDIHNPVIYWVSQEGNLNIADIEGCVCNMVLSPDSGKGLPPTS-LTVDKVNVYWSNIDQDQVYFINKLNPDDTEIKKFHLYSARS---LKAIGNSLQPYPFAECLIPRQVSYNVELIEKFANSIKIKLPEPVPHFGCDKFHLPATLYTVYI--------TECLVNDPRDCKN------RERVRVQS-----YEKLIEAKNLKPFTKYMFQVGLSNYYSELESSTLELGPGNIIRTDAGAPTRPENVVVQALTPTLASINWMPPKVLNGAVVRYEIHWRSAQLVNGIRQKGEQLIKNTEQPADGKLSAMLQPLLPGQEYLVYVRAYSAHSTTSYNESVPLSVRMYPEPNNLTLTGQSINSMNVSWAPNESITIVYHLEYSIVGLE--------KWQIATNSVKRNDKVEFIIQNLRPRTLYRFQ--LVLRYPNYNQDFIWPADA-RFTFETSGDVPSAPGIP-ISTKLRGSVHQISWEPAQAHGSQITLYRLEGRVVEDSNLVEENRNDTSQWNLYYNGTDASWISVGEMNQKYQFRVQARNAYGFGKWSEISGVVDLTEAVSGILVARQHLGLVLGLSVPL--ILGVMLLCFGVFLCPVYRQRKEDKKVVIP-PTMPDVELATLREIP--RGNFVQSNALYASAIQNDPDDSALPKIKREQITLAKFLGSGAFGEVFQGDAKDL 2033 HSP 2 Score: 209.534 bits (532), Expect = 2.413e-50 Identity = 96/168 (57.14%), Postives = 123/168 (73.21%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
L L DL +C DVA+GC YL ++ ++HRD+A RNCLVS+ D ++RVVKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVL+WEI +LG+ PYP NL+V+ V GG P NCP L LMLRCW+ D RP+F+ CL + L
Sbjct: 2116 LRLQDLLAMCEDVARGCRYLEELHFVHRDLACRNCLVSARDRENRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQ-QPYPARTNLEVLYHVRAGGRLPKPLNCPTALHQLMLRCWST-ADARPSFKACLDHIITL 2281
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|1004403082|gb|KYB29372.1| (sevenless [Tribolium castaneum]) HSP 1 Score: 325.865 bits (834), Expect = 3.981e-86 Identity = 392/1628 (24.08%), Postives = 683/1628 (41.95%), Query Frame = 0
Query: 15 SVNGNVFWHT-GNEIWTVSKCDPSSSKR-------IVHRAKLG--SMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGI--LFHYNDSYYWTNANVLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEI-----QPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQAEETNL----VTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSLPEGPTDLVLTWIRKGQVFQSDLLGTN------HSRV------ELPFKARHVACRSGDAVLLSTDTSLLSAQGQILFKANAEISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFFTRKDGSQTVIHQMDLEDLSIPVQ---VVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTILLGGRGGRITDLCVQGAPRQMVPQ--DLDITPLTVDLDSLKL---EEDSKLVWRALT----GEVTYHLLIQVHGRQ-YALQTTTSELDLAQEIASLTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF----HNAVNSSIIVRWNPPKLPNGHITGYQMEINSLDT---------IIVHPDTLEQVLVELPSQQLH-IDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRR----IRATYDVGAIQTLDFQGPKAVFSQGGSIFALNLINHVRERVLTQAELILHLRVDWISNCIFFVAVSGSDYSIRRFS-----VDSGV--LSNVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELS----LFGRIKSLKPTSTHAQCSCFQMDPRSPFYFTLRPNIPEQKASLTLLTHD--GSLFATDNGCECQLMRK------IPAWSQLSSDGSNLYWKSHEFVQYLNLQEGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVP-SLVEQRVTILEAGEDWLRVSLPQFRAPCTN-SLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTLIKDLEPFTRYGIYLSLQKGKPSQQTIPTELIALAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQK----------PTEKEFSVELKDLEPGEIYKIWVEARTGSSKV-AQSAEIEAQTFSRVSLPEITTRTPRSVTFIWRSPPIKAIQAFQFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAW----NSNNDLVESFELQA-RIHDSNVTVEDNVTM------------SNWSVVYADTSPQWPISGLSDA-AYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKS--ALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
+V G +FW G ++ + D S+ R I+ KL + +D + RL V + + ++ V D +I+N+ R +S E + L N +YWTN + + N S +F +S+ D+ L T + I QPIP P+NP V+ FG+N +A+ W P WQ W+Y++ ++ + ++K N ++ + T + A + G+ WS +L ++ W + ++D G N SR+ ++ + V + D+ + DT S QGQ++ + + + + +Y PK I+R + +E L I K L++DS+ A L W G ++ C+ L G + + L+S + L +D +++ + + + + + S + +T L+ G L Y+H +L W+QD DL G + +TI G +T + V + ++P ++ + P TVD +S+++ + W + G+V Y + I R A+ T ++ + Q++A P T+++V + A + W SPQ+ +++P S P +LRA+ + N +I VRW PP PNG + GY++ L+ ++ P+ Q+ + P ++ +++ + G S + N LP++L+ + D+D R + I L + Q ++ +++ + ++ + + + VDW+ I++ D F VD G+ +S V T I +E+ P T LY+ + K + + S F + K K ++ C+C +D +TL + E K L + D + A NGC C ++ +P +L SD LYW + + L +E + + R+ I F P Q P +CL P L RVT+ E L + +P+ C + S+P VE+ IYY I +C L + +F IK L+PFT Y + +++ ++ I + QT G P PP+NVT L+P +V+W PP+ NG VHYE++ T R SG RQK P ++ L L P E Y IWV+A + +++ + S +++ T+ S + RT +T W I + ++ P+ SN W + + G ++L P TQY + L++ YIWPQDS R + ET D P PG P + + + +Y W N +E ++L+ + + N T W Y T W I+GLS+ Y FRV A N +GWS S+ + ++ +++ + + TLI ++ I + V ++++L I R+ K + I R ++ELAT+ ELP G +N Y P+ +EM +P ++R+QITL+ F+G GAFG+V
Sbjct: 396 AVAGYLFWGIHGTGLYRLDISDFSNGIRHEVQPVLILSEKKLNMSAFTVDHTNFRLFVANEREK---TINTVSLDGKEIINV----RPNVIKSKLENVVSLATANKKFYWTNGDDIFYEEYHN-SVYFHNSYP-DLSLSTKSYKKVIINLQSSQPIPSPVNPPTNVQAIFGSN------IAKTTWLPPHLLGIQGKGAWQNWSYEVAIK-EVGSQKFISHRNINTTSYKISGLRENTEYVIKAAAYTRSGQGPWSSEFRGFTLSRSKNPMIY-WSAAKGLLRTDAAGENVETLIHKSRIKGSVFIDMTWYQDLVYLVTNDSHVYWYDTRSHS-QGQLI--GIDSVGSIAVDWIGKKLYWSNPKRQMIIRGNLNGTQQEPLPILTLA-KELNIDSVKAYLYW-STGFAVRCAHLNGENLIEYHPVQLFSGRQVMGLTLDMHNKFVYWIVRGLEGSNLFRAPMAGYSEKITENFKITSLQKPNMQGPLCYFHKRLLWLQDNKNAAISDLQGNNIATIS-GKSMSDLTLVYVVDSSLHVMPDIPEIVVIPETVDKNSVRVIGSLNSFNVTWNPVKNVNYGQVFYEVSIDSLLRNDSAIVTNSTSVRYWQQVA---PFTKLQVAIRAFTYWGTSPQIRAKVYSPASTPSVPTNLRAYVTHHSSGTNVTITVRWGPPLFPNGVLKGYKIHCWYLNAAQRRDVCRDLVKKPEEF-QIDFKPPHDHIYYFNVQAFSEMGDGDLSDPIQVNSSQELPLPRLLV---ASEDSIFIQDIDSDRNESLLHGIVTPTEIGYLIKESKLFWIDQLQNLMMYDMLKGNKTKITSLRNNVTGVTVDWLERSIYYAQSENWDSGSSVFKLDLNYVDRGIVKMSKVFFTPASISKIEVSPYTRKLYW--VEKSKLMVCNTDGSDKSEFFNKNKYTKRSTLGGGCNC-PVDVNIEKTYTLDHST-ETKPLLVFVESDTQNVVSADKNGCSCSVIANNSLGVTLPL-DRLKSDFGTLYWTNSRLLHALRKKEANLVTKEVNGRD----ILIFGPHMQPFPPSECLRPRQLANIRVTLKEKTATSLTLVMPEVGQICADTSMPTVEYRIYY----------AEKIDNNTCD--------LTCNFSATFDKEFT--IKSLKPFTHYVVAVAVSNYYTEEEEIVLGPSTVFQTAVGAPSPPQNVTVKVLNPTMAQVSWSPPQHPNG----VTVHYEIY--CQTERTLSGVRQKEQSNVEQQFTPNSHFLTIVLNKLSPNETYTIWVKAYSETNETSSDSDKVQINTYPEPSDLILVNRTAYMLTVTWDV--CANIDHYNVQMSPVTSN------DW---RNVSESGEGIFASEENLQPKTQYKFRLSLSYY--NYPEEYIWPQDS-RFVYETLGDKPSPPGTPKI--QYVKPNIYKVWWEEAKDNGAPIELYKLEGLELPNYRTKRSTNRTAFFYTAPSVEEEEREWQQFYNGTETSWIINGLSEKYKYEFRVLALNAYGWSDPSDSSTAFDLN--EAARMAEKQSPMTLIAIATFIP--VSVFLIILLCIVCRKYGKPKKVQVVSIPRGPDVELATLRELP--RRGIHNTNVLYVSTQPTSEEMTLLPHIRRDQITLMKFLGSGAFGEV 1936 HSP 2 Score: 228.409 bits (581), Expect = 3.344e-56 Identity = 103/168 (61.31%), Postives = 129/168 (76.79%), Query Frame = 0
Query: 1535 LTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
L+L +L ++C DVAKGC YL +M ++HRD+A RNCLVSS D DR+VKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVLLWEIM LG+ PYP NNL+V+ +V GG P +CPE L NLML+CW F D+RPTF+ CL + L
Sbjct: 2027 LSLIELLKMCVDVAKGCRYLEEMHFVHRDLACRNCLVSSKDP-DRIVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLLWEIMTLGQ-QPYPARNNLEVLHYVRRGGRLGKPTDCPETLHNLMLKCWEFEADKRPTFKYCLDVLDNL 2192
BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Match: gi|915664849|gb|KOC66937.1| (Proto-oncogene tyrosine-protein kinase ROS [Habropoda laboriosa]) HSP 1 Score: 317.005 bits (811), Expect = 2.693e-83 Identity = 387/1632 (23.71%), Postives = 691/1632 (42.34%), Query Frame = 0
Query: 1 LAEKLGRIVDLQLDSVNGNVFWHTGNEIWTVSKCDPSSSKR-------IVHRAKLGSMGIDFGSNRLLVVDLEQDELLMLDLVDHDHAKILNLTFEERQRPFQSMSEGILFHYNDSYYWTNAN-VLHQLMGDNRSGHFQSSFKEDIDLRTSVFHHPEIQPIPVPLNPVLKVELSFGTNFLGCSSVARVKWEPSD--NSANPCVWQQWTYDIRLESKSATEKVFQ---AEETNLVTCVEHGTVFNASVRAVSEGGKSEWSIPVSAQSLPEGPTDLVLTWIRKGQVFQSDLLGTN------HSRVELPFKARHVACRS--GDAVLLSTDTSLL---SAQGQILFKANAE-ISGLLFEPFSESVYTMVPKSDEILRIPRPNSSEEVLKIPARGVKALDLDSLLAKLCWIRYGTSIVCSSLFGTSPRAILELDLWSESLISDLVIDGLGHRLFF-TRKDGSQTVIHQMDLEDLSIPV------QVVTILEHSTRSGSLNYYHDKLQWIQDGNQLVTFDLVGQSWSTI----LLGGRGGRITDLCVQGAPRQMVPQDLDITPLTVDLDSLKLE---EDSKLVWRALT----GEVTYHLLIQVHGRQYALQTTTSELDLAQEIAS-LTPNTEVRVTLIAASNWSKSPQVEKTLFTPPQISSPPQHLRAF--------HNAVNSSIIVRWNPPKLPNGHITGY---------QMEINSLDTIIVHPDTLEQVLVE--LPSQQLHIDLRCQNNAGLSPASTLLIQNRFVLPSLPQILIYQGIQGGKLDFYDLDRRRIRATYDVGAIQTLDFQGPKAVF--SQGGSIFALNLINHVRERVLTQAELILHLRVDWISNCIFFVAVSGSDYSIRRFSVD-----SGVLS--NVTHTQDDIQHMELDPLTNTLYYTTLTSGKFQLNKLELSLFGRIKSLKPTSTHAQ-CSCFQMDPRSPFYFTLRPNIPEQKASLTLLTHDGSLFATD-NGCECQLM------RKIPAWSQLSSDGSNLYWK--SHEFVQYLNLQ---EGQISHFNGSSRNEGVIIRPFCPDCQMTPIKQCLVPSLVEQRVTILEAGEDWLRVSLPQF--RAPC-TNSLPQVEFTIYYYVIESQGHSELPSITPESCSSHPSLCLKLQVPIQGPEESQFQTL-----IKDLEPFTRYGIYLSLQKGKPSQQTIPTELIA--LAQTLDGQPGPPENVTATALDPETIEVAWLPPKVANGKFIIYDVHYELHKVITTSRIPSGHRQKPTEK----EFSVELKDLEPGEIYKIWVEARTGSSKVAQSAEIEAQTFSRVSLPEITTRTPRSVTFI---WRSPPIKAIQAF--QFRLVPLKSNLNASQYQWPMELSSIQPGHQYQGQIKSLNPGTQYGLQGVLTFRIGQRTHTYIWPQDSKRILVETPPDAPLIPGQPYVMEKVSESQVYLAW---NSNNDLVESFELQA-RIHDSNVTVEDNVTMSNWSVVYADTSPQWPISGLSDAAYLFRVRAKNEFGWSQFSEDTPPLNIGLILSSKGLFQSNSGTLIGLSAGIVGIIGVLVVVVLIIFLRRPWDKKSALGIQRHRELELATIHELPVMLNGGMESNPTYGVQIPSEQEMEDIPKLKRNQITLVNFIGCGAFGQV 1524
+A L R +++D NG +FW T ++ + D S+ + I+ A LG+ +D + RLLV Q+ ++ + L D ++L+L +Q F+++ L N +YWTN VL + ++ +F +++ D F + PV + LG A+V W+ WQ W+Y++ ++ +S E + Q A ++ V + + ++ A + G+ WS ++L +G +L W + +SD+ G N + ++ P H+ S D + + + S L + K N + + + S+ +Y PK I R S +E + I A VK L +DSL A L W G ++ + L G R ++++ + L +D +++ R S +++++ + IP+ + V+ L+H G L Y+ + L W+QD V DL GQ+ + I L G I D + P+ + + + + P V+ S+++E + + W + G V Y + + + T+E + + + P + + VT+ A + W + K L +P I S P + RAF V+ I RW+ P+ NG ITGY + I D + P TL + V+ LP+ + + G P + L+ + +PQ+L+ + DLD+ A++ ++ ++ + +L ++LT L + +DW++ +++ S + R +D G+L N+ + I ++++ P T +LY+ LT + ++ L GR +++P H CSC P N QK + ++ +G L D +GC C L+ + +P + L+ D N+YW + + + ++N + +G+I HF S I+ Q PI CL+P V V ++ + + V LPQ + C T SLP +TIY + + P++C + + ++FQT IKDL+PFT+Y + L+L +++ E + + +T G P PENVT AL P V W+PPK+ N + Y+VH+ L ++I +R K TE+ F L+ P + Y ++V A S E Q P T T SV + W P I + +++ V +++ W + S + IK L P T Y + L R ++WP D R +T D P PG P V K+ S L W ++ + + ++ +I++ N + D+ ++W + Y T W I+G D Y FRV+A+N +G+ +S +P +++ Q + G ++GLS ++ I+ + L ++ +R DKK+ L ++ELAT+ E+P ++SN Y + ++ + +PK++R QITL F+G GAFG+V
Sbjct: 341 VAGFLTRPTHIEVDPYNGYLFWVTRGGLYRLDLADISNGVKHEVQPYLILEDAHLGAFTVDHTNFRLLVPHHIQNTVISVSL---DGREVLDLRSNTQQPKFKNVVS--LAMANGLFYWTNGEEVLIEGYHSGQNRYFHNAYP---DRSNGSFVSVNVLMDASQPVPVPVNPPTGVQAVLGVER-AKVSWQAPHLLGGQGKGAWQNWSYELEIKDESTGETIHQKDIAGSSHTVHNLREKSEYSIKAAAYTSAGRGPWSTEFRGRTLRDGSHASIL-WSANEGLLRSDVTGENIDTLIYKASLKEPETDYHIVDVSWYKDILYIVGNNSALYRYNITNHQKMKMNIHSVGSVAVDWISKKLYWANPKQQIITRANLNGSQQEPMSILAI-VKELMIDSLEAYLYW-STGHAVEVARLNGQDRRYYHSDEIFNGKQVMGLTLDTENRYVYWIVRSYESGSIVYRAPTSE-KIPMTHKIMPEKVSALQHPNMQGPLCYFSEHLLWLQDDRNAVIGDLSGQNTAIINGITLSGLHMVAIMDPALHQYPKNLSSETVVVLPNAVNYSSIRVEGTWRNFNISWDPVENINYGTVFYEVKFADYINTNSNPEITTETSMPYNNSEQILPYSVLEVTVKAFTYWETAHHTRKILRSPQSIPSQPTNSRAFIEFHKEPLSENVDIFAIFRWDQPEFTNGLITGYTVMCWFKEDHVPIQFCDHKSLIPSTLLEHTVQDLLPNTTYYFQVSAHTEIGAGPYTDLINVSTIYENPVPQLLV---ATMDAVRISDLDQEVNYTITRHIAVEVTYMAAENKIYWINEMQELVTSDLNGANATKMLTLNNSALSITIDWVARHLYWSESSYRENGGRVMKLDLTMWHDGILKYENIIASSRRIVNLDILPSTGSLYWIELTKKDGGI-IMQSDLNGR--AIQPFFNHIDDCSCPYRPSVIPVMTIDSTNY--QKPVMYWISMEGHLNIADIDGCACSLIVSAGFNKGLPP-TSLTVDKMNIYWSNIAEDQIYFVNKKYPDDGEIKHFYLPSVRS---IKALGKSLQTYPITNCLIPHQVSYNVEEVKKTANSITVRLPQPVPQFGCETYSLPTTLYTIY---------------VSQCLENDPNMC-------EDSDRTKFQTYEEEYEIKDLKPFTKYRLKLALSNYYADLESMSLEFGSGVVLRTEAGAPTAPENVTVEALTPTLAVVYWMPPKILNAAAVRYEVHWRLVRLINGARQKGEQFIKGTERTTDGRFFTMLEPWLPDQEYLVFVRAYPAHVNDVYS-ESPGQVVKMYPEPNNLTLTGVSVNGLNVTW-VPTINLTIRYTLEYKDVAVEN--------WQVANDSKMVNEKLTYFIKKLQPRTLYKFR--LILRYPNYKLDFVWPTDG-RFTFQTLGDVPSAPGMPTVT-KLRNSVYQLNWEPAQAHGSQITLYRVEGMKINEINEQI-DSSENASWKLFYNGTDNYWIITGDMDDKYRFRVKARNAYGFGGWSRSSPIIDLTETTGGILAAQQHLGLVLGLSVPVITIMLICFCYFLCLYRQRKEDKKAVLP-PLVSDVELATLREIP--RGNFVQSNALYASTLQNDPDDSTLPKIRREQITLAKFLGSGAFGEV 1907 HSP 2 Score: 211.075 bits (536), Expect = 7.799e-51 Identity = 97/171 (56.73%), Postives = 124/171 (72.51%), Query Frame = 0
Query: 1532 LLKLTLADLGQICCDVAKGCAYLSDMQYIHRDIAARNCLVSSLDAKDRVVKIGDFGLARDIYKDAYYRKNGQSLLPIKWMAPESLADNKYTTKSDVWSFGVLLWEIMNLGRCPPYPDMNNLDVMVFVPNGGHPKVPPNCPERLKNLMLRCWAFHPDQRPTFRDCLHEVQEL 1702
L L L DL +C DVA+GC YL ++ ++HRD+A RNCLVS+ D ++RVVKIGDFGLARDIYK+ YYRK G+ LLP++WMAPESL D +T++SDVW+FGVL+WEI +LG+ PYP NL+V+ V GG P NCP L LMLRCW+ D RP+F+ CL + L
Sbjct: 1995 LHALRLQDLLAMCEDVARGCRYLEELHFVHRDLACRNCLVSARDRENRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQ-QPYPARTNLEVLHHVRAGGRLPKPMNCPPGLHQLMLRCWS-AADARPSFKACLEHIVSL 2163 The following BLAST results are available for this feature:
BLAST of proto-oncogene tyrosine-protein kinase ros vs. L. salmonis genes
Analysis Date: 2018-04-19 (T. kinsejongensis vs L. Salmonis peptides) Total hits: 25
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BLAST of proto-oncogene tyrosine-protein kinase ros vs. SwissProt
Analysis Date: 2018-04-19 (T. kingejongensis peptided Blastp vs. SwissProt) Total hits: 25
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BLAST of proto-oncogene tyrosine-protein kinase ros vs. nr
Analysis Date: 2018-05-15 (T. kingsejongensis proteins Blastp vs. NR) Total hits: 25
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The following features are aligned
Analyses
This gene is derived from or has results from the following analyses
Properties
Relationships
The following mRNA feature(s) are a part of this gene:
Sequences
The following sequences are available for this feature:
gene from alignment at scaffold233_size243130:137587..149272- Legend: mRNA Hold the cursor over a type above to highlight its positions in the sequence below.>maker-scaffold233_size243130-snap-gene-1.22 ID=maker-scaffold233_size243130-snap-gene-1.22|Name=proto-oncogene tyrosine-protein kinase ros|organism=Tigriopus kingsejongensis|type=gene|length=11686bp|location=Sequence derived from alignment at scaffold233_size243130:137587..149272- (Tigriopus kingsejongensis)back to top Synonyms
The feature 'proto-oncogene tyrosine-protein kinase ros' has the following synonyms
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