Query:   40 EYLSSDRYFESGPFGGTQGGEWFTDFSQSLDGRTFRPTHWPDAINIRSGDRVDSIQMFYGPYHGGFHGGEGGTLQKFRLYDGNRIVRVTGRKGVGPGAGVDQLSFFTQDGQRFGPYGG-IGGYYFESRPPQSDCYLAWISGRANFRIDSISFHWRC 194
            E ++   +F+SGP+G T  GEWFTDF QS DG  F P +WPD INIR G R+D IQ+FYG Y G  HGGEGG   + +LY G+RIV+V GR G+G  AG+D L  FT  G+ FGPYG    G  FE+ P ++DC LAWI GRA FR+D ++F W+C
Sbjct:   19 ELINQYDFFKSGPYGSTTEGEWFTDFWQSSDGLQFIPKNWPDGINIRYGARIDGIQLFYGNYIGKMHGGEGGRSIRIKLYKGDRIVKVKGRHGIGYRAGIDSLELFTSRGKHFGPYGDEKSGRSFEATPGRTDCALAWIYGRARFRLDGVTFVWKC 174          

Query:  409 ERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAES-FNWTAFVEPLSWSCWGVIALFILVVPLGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNN---PMLQQIWTERIEPYIDG------YPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQ--ILEKYEAEKQIC 778
            ERR +L   T  +   FN     ++ +  R S  F  +F  + H     +NY       PD  +G +L    +NG++G + R E+DI+P +FT  + R++  DFS  + ++   LF++N   S F W + +    W  W  I    LV  L +   I+    R      +  SF  V   +               R++  +I L G L+ W +   +IS      + LP  S+ ++ T +D+R+ +  GT+  D F  + N   P +   +    +  I+G      +P  KI    +I+     Y      +T +T      C++ A  +    +   + +++   Y + F YQL K+KE G   +   L + + + ++C
Sbjct:  197 ERRKNLSGVTINVGY-FN----HEIFDPIRQSGFFYELFFMIAHNFNLRINYI----NCPDNIYGIRLNGSVYNGILGMIQRGEVDISPMDFTKISARTKDFDFSTFLLKTKLMLFMQNKKFSEFQWYSILHVFDWQFWISILCLSLVFTL-VVFFIRRAIQRTSEIPIVFPSFLMVFFTLLGQEPSPCINKITSLRLLILNISLFGALISWIFNGSLISVFTSVKSSLPVQSLNDLVTHSDYRLIIANGTAVTDWFTNTENETDPSVLDRYRMVYQKIIEGNEEKVFFPFDKIP---EILATNKKYVYLGEEFTMLTQTKDYPCRLQASXLDLGRLDLGWIYKRNFEYREFFEYQLKKLKETGMIDREWKLLQIKVKSRLC 565          

Query:  382 SSPKIEILPYGTWNASTGLSL-------KGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWG-TKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVK----NPAESFNWT-AFVEPLSWSCWGVIALFILVVPLGMSHAIKMG----------NDREK----GEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIW-----TERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEK--------------QICPDYSGKPLGFGQCFTAFIALMGGMVLGFISLLME 812
            SS    +   G+WN+ +GLSL       +   I +   D  + T  I      PY+    E       + G   D+  A+AE + + + L   PD  +G      G WNG++ QL     D+A A  T+   R  V+DF+ P       +  K     P E  N   +F+ PL+   W  I    ++V + +    +             DR +     +FTL  SF F  G + + +G  V P +   RI+     FF++++  +     + A + +FL V     P  S E++  +++       G S +  FR S     Q++W         E ++  Y     G+  K++  + NYA      T + Y   + C +  +        +  A  K S + D     +  ++E+G  +    K+   K              ++        LG       F+ L+ G+ +  I  +ME
Sbjct:  326 SSKSYSVRQLGSWNSDSGLSLFNGTEEPEDYTIVDPEED--KETLIIVTKEERPYVM-FQEGLIGINAYDGFAIDLIKAIAEVLGFKYRLYTVPDNLYGFYNHETGEWNGIVKQLIDKRADLAVASMTINYARETVIDFTKPFMNLGISILFKAPKPQPTEHVNQLFSFMNPLALEIWLYILFAYVLVSITIWIIARFSPYEWAYPNPCQDRNRLVFQNDFTLPNSFWFAIGTL-MQQGSDVNPKAASTRIVGGIWWFFTLIMISS-----YTANLAAFLTVERMAXPIESAEDLAKQSNIGYGTLAGGSTMTFFRDSKVGNYQKMWRYMESKGENESFVTSYES---GVE-KVL--SGNYAFLGE-STMLDYLVQRNCNLTQIGDLIDSKGYGIATPKGSKWRDKISQAILFLQEKGVIQMYYNKWWRNKSQSTSSSTHCSTKPRVVDSVKANALGIVNIGGIFVVLLCGLAVAVIVAIME 791          

Query:  398 TGLSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFV----KNPAESFNWTAFVEPLSWSCWGVIA----------LFILVVPLGMSHAI-KMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFR---------------YSNNPMLQQIWTERIE----PYIDGYPKTKIGLSLKIIEETSNYAL--------------FDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKY---EAEKQICP--DYSGKPLGFGQCFTAFIALMGGMVLGFISLLME-----KLMPQRSWSRINRTVDDLNMKKSAIMHGISFASTF 847
            TG+SL+G+          +  ++I +    P+I+K   N ++   + G   D+ + L E + + + +   PDG +G    +  WNGMI +L   + DIA    +V A R  V+DF++P  +    + +    K P   F + + +E   W C  ++A          +F    P    + + K  +D EK  F   +   F   ++T  +G    P ++  R++  +  L G ++   + A + +FL V     P  S+E++  +   + A   G++ +  F                 S N  L ++   ++     P  D Y K    +    + +T   AL              F    T I Y+    C +  V   +    +A A Q+ SP  D F   + K+  +   + + E++    + K+ C   D SG  +        FI +  G+ L  I+L+ E       +PQ   S  N     L +K++       F+ST+
Sbjct:  305 TGMSLQGVG--------AKTIYKIVSVMQAPFISKEMINGKA--VYSGYCIDLINELKELIEFEYEIYESPDGQYGRMDDNEEWNGMIRELIDKKADIALGALSVMAERENVIDFTVPYYDLVGIIIMMKKPKLPTSLFKFLSVLEDEVWIC--ILAAYFATSFLMWIFDKYSPYSYQNNVEKYEDDDEKRYFNFKECLWFCLTSLT-PQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLETPVESLEDLSKQYKIQYAPMNGSATMTYFERMAYIEDKFYEIWKDMSLNDSLSELEKSKLAVWDYPVSDKYTKMWQSMKEAKLPQTFEEALERVRQSPTSSEGFAFLGDATDIRYQVLTNCDLQMVGEEFSRKPYALAVQQGSPLKDQFNDAILKLLNQRKLETLKERWWNGNSNKKNCEEDDDSGGGISIYNIGGVFIVIFVGIGLAIITLIFEYWYYKYKVPQIQISDPN--TKQLQIKQAHFRDKTDFSSTY 797          

Query:  392 GTWNASTGLSL----KGLPIWERRADLKRHTFRIAANFNPPY--ITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQ--LYRDE--IDIAPAEFTVTALRSQVVDFSLP-ITESHQKLFVKNPAESFNWTAFVEPLSWSCW---GVIALFILVVPLGMSH-----------AIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIW 676
            G+W    GL++    + + +      +   TF +    N PY  +   T+  + +  F+G   D+   ++E +++        DG +G +   G+WNG+I +  L  D+   D A A  ++T  RS  V FS+P +T     +++K      +  +F+ P +   W   G   +F+ VV   ++             I+   + E  +F +  SF F  G++ + +G  V P +   R++     FF++++  +     + A + +FL V T   PF S E++  +TD +  V  G S  + F+ S     Q++W
Sbjct:  401 GSWTTIDGLNISRVEEKVQVINPTNIMANRTFVVTLIENAPYTMLKLETKRLKGNDRFEGFAIDLMKDISEILDFNITFKLVDDGKYGNQDEHGNWNGLIKEVLLGADDGGADFAVAXLSITTARSTAVVFSMPWMTLGISIVYIKARPAPPDLLSFLSPFTLEVWIYTGFAFVFVSVVLYVLARFSPYEWNNPYPCIEEPEELEN-QFNIVNSFWFTIGSL-MQQGSDVAPTATSTRLVAGMWYFFALIMISS-----YTANLAAFLTVETLEKPFESAEDLAKQTDIKYGVVEGGSTENFFKTSTFETYQKMW 708          

Query:  430 ITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGT-KLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNP-AESFNWTAFVEPLSWSCWGVIALFILVVPL--------------GMSHAIKMGNDREKGE----------------------------------------FTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEK------QICPDYSGKPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWSR 822
            I  +T N R    F+G   D+   +++ + + +  +   DG +G       +W GMIG+L   + D+A A+ T+T  R Q VDF++P       +  K P A+     +F+ PL+   W  +    L V L              G+ + +   ND EKG                                         FTL  SF F+  ++ + +G  + P ++  R++     FF++++  +     + A + +FL V     P  S E++  +           S    FR S  P   ++W   ++     + K+      ++I+E   YA F    TT+ Y   +KC +  +        +  A    SP+       + +++E G    + EK+  ++      Q  P+     L        F+ L+GG+ +  I  + E L  +R   +
Sbjct:  391 ILALTGNAR----FEGYNVDLIDEISKILGFNYSFHMVEDGTYGXYDEKTKTWXGMIGELLSQKADLAVADLTITYEREQGVDFTMPFMNLGVTILFKKPKAKDPYLFSFLSPLALXVWIYMMXAYLAVSLLLFILARISPYETSGVVNDVYWRND-EKGSRLARPDPIYETLFSGCGRPVRTIGTQVEDRREQEKNSGDTFTLLNSFWFMIASL-LQQGTDLLPRAVSTRMVAGMWWFFTLIMISS-----YTANLAAFLTVERMDSPIESAEDLAKQNTISYGSLRAGSTAAFFRDSKIPTYSRMWV-FMDSDDKNFVKSNSAGVERVIKENGKYA-FLMESTTVEYIVERKCDLTQIGGLLDSKGYGIALPPNSPFRTPISSAILQLQEGGKLHMLKEKWWKQRKGGGKCQEVPEKEAAALNLSNVGGVFVVLLGGLGVACIIAVAEYLWNKRQMQK 837          

Query:  435 ENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWTAFVEPLSWSCWGVIALFILVVPLGM--------SHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVL-PFSSMEEMF---TKTDFRVAVQPGTSYVDTFRYSNNP-----MLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYA-LFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQL 755
            EN    +C  G   D+ +  +  +++ F +    DG WG  + +G WNG++ +L   E DI      + + R +V+DFS+P  E+   + V       + TAF+EP     W ++AL  + +  G              M     +G F+  ++       +  A      P     R +            W   A+I  FLA+ T  L  F    E F   T  D R  V P TS   +FR+   P      + +    ++  Y++ + ++ +    K ++    +A ++D            +C I+ V   Y    +   F K SP+   F + L
Sbjct:  506 ENSTYFQCCSGFCVDLLNKFSVDLSFDFKMMRVRDGKWG-GIVNGQWNGLVKELINHETDIVMTSLKINSGREKVIDFSVPFLETGITILVAKRTGIISPTAFLEPFDIVSWMLVALVAIQIAAGFIFLFEWISPAGYNMKFKHSQGRFSFLRTLWLXWAXLFQAAVNVDCPRGYTARFMAH---------IWAMFALI--FLAIYTANLAAFMITREEFPNLTGMDDRRLVNP-TSVKPSFRFGTIPNGATDYIMKNNFPQVHSYMNKFNRSTVKEGFKAVKNDRLHAFIYDATVLEYLVGQDDECDILTVGSWYAMTGYGVGFPKGSPWIPLFNHYL 831          

Query:  469 DGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWTAFVEPLSWSCWGVIALFILVV--PLGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTF--RYSNNPMLQQIWTERIEPYIDGY------PKTKIGLSLKIIEETSNYALF-DNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQK 743
            +G WG    +G WNGM+G + R+E+D A   F V   R Q   F++PI   +    V       NWT F +P   S W +I   I      +G  H  K+          +S ++  + G    +  W+   + I  RI     ML   ++   +   + S LAV    +P +S++++  + +    ++ G S +D      + +    +++    E  I G        + + GL   + E TS   L  D+F  T       +C++    +  F   FA AFQK
Sbjct:   27 NGQWGVGDENGEWNGMLGMVKRNEVDFALGPFGVIYEREQACXFTVPIVIDYWAAVVPIQPYRNNWTIF-KPFGLSLWLMIISDITFFGRRIGHKHVPKI----------ISFTYRNILGE---SSEWAPDKF-IYQRIFSAVWMLSLIIIAKSYSGTLASLLAVPNIPIPINSVQDLVNQDELPWIIEKG-SILDQLGQMAAQDTTFYKLYDGAKERGIIGANCVQKRKEIRNGLFGSVCERTSIDKLISDDFSGT------GECKLYVGEINLFATSFAMAFQK 290          

Query:  403 KGLPIWERRADLK--RHTFRIAANFNPPYI--------TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLP-DGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLP-ITESHQKLFVKNPAESFNWTAFVEPLSWSCW-GVIALFILVV----------PLGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGT 658
            KGL +W+   +L   + +F+I    +PP++          V +     +  +G   ++    +E+MN+ + L      ++G   P +G+W+G++  L    +D+  ++ T T  R +V+DF  P   +S   +  +NP    +   F+E L    W  ++   IL            P    + +   N   +  F L +SF F   + T  +G   +P SI  RI+  +  L   L+   + A + +FL V        +++E+  ++    +V   T
Sbjct:  213 KGL-VWKDTTNLVTLKRSFKIGVIISPPWLFFLKDMNGNFVKDPKTGEKVLRGYLLELIQKFSESMNFEYEL--IFSESYGRYDPTNGTWDGLVSFLTNGNVDMVISDLTTTLEREEVIDFISPYFYQSGFAIIFRNPVPKRSLFKFMEVLKSEVWLSILGALILTAFLLWFLEKYSPFSARNNLDKYNKPVRI-FDLKESFWFATTSFT-PQGGGDSPKSISGRILTSAYWLFVVLILATFTANLAAFLTVERMRTSIKNLDELVQQSKINFSVVGNT 486          

Query:  442 CFQGMFPDVWHALAETMNYTFFLNPP--PDGAWGTKLPDGS--WNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWTAFVEPLSWSCWGVIALFILVV-----------PLGMSHA-IKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKT---DFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYA-LFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKY 771
            C  G   D+   LAE  N+T+ L+      G+       G   WNG+IG+L      +  A  T+   R+ V++FS P       +  K    +    +F++P  ++ W ++ + + +V           P G  H+    GN +++     + +  F  G +  +     TP S   R++         ++   + A + +FL +       + + +   +    +F  A   G+S    FR       +Q+    +   ++         +++ ++E    A ++D+  + + YE  + C +I     +    +    QK SP+ D     +    E G  + +  K+
Sbjct:  487 CCSGYCIDLLKLLAEHCNFTYSLHVSFIEYGSLERNNETGKLEWNGLIGELVDGXAXLIVAPLTINPERAHVMEFSKPFKYQGITILQKRQPRASQLVSFLQPFKYTLWVLVLVSVHIVALCLYLLDRFSPFGRFHSGPDPGNVQKEESLNFTSAIWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLDKPQTSLTGINDPRLRNPMENFTYATVKGSSVDMYFR-------RQVELSNMYRTMEXKHXRXPEXAIRAVKEEKLKAFIWDS--SRLEYEAARDCDLITAGDLFGRSGYGVGLQKGSPWADKVTLAILDFHESGKMEDLDNKW 827          

Query:  376 VYKIHMSSPKIEILPYGTWNASTG-LSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFP------DVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAES-FNWTAFVEPLSWSCW--------GVIALFILVVP-------LGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSGKPLGFGQCFT------AFIALMGGMVLGFISLLMEKLMPQRSWSRINR 825
            VY + M+    +I   G WN   G L      +++  +     T  +      PY+  V    R  +   G  P      D+  A+AE + + F +    DG++G+ L +G+W+G++G+L R E D+A A FT+TA RS+V+DF+ P       + +K P  +  ++ +F+EPLS   W        GV  +  LV         L  +H   + ND     F++S S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   + P  S E++  +T+ +       S    F+ S     Q++W          + KT      ++ +    YA      T       K C  + V        F       S   D   + + +++E G   +  EK   ++  CP +S    G     T       F  L+GG+V+  +S   E L   R  SR +R
Sbjct:  386 VYNVAMTRGTAKI---GYWNEREGKLHAHNPRLFQNNSSDMNRTRIVTTIIKEPYVM-VNNVIRDGKPLVGNEPVEGFCIDLTKAVAEKVGFDFVIQFVKDGSYGSVLSNGTWDGIVGELIRHEADMAIAPFTITADRSRVIDFTKPFMSLGISIMIKRPQPAGKHFFSFMEPLSSEIWMCIVFAYIGVSVVLFLVSRFSPNEWHLSEAHHSYIAND-----FSISNSLWFSLGAF-MQQGCDISPRSMSGRIVGSVWWFFTL-----IIISSYTANLAAFLTVERMLTPIDSAEDLARQTEIQYGTIMSGSTKAFFKNSQFQTYQRMWAYMTSAQPSVFVKTHEEGIQRVRQSNGKYAYLTESSTIDYVSNRKPCDTLKVGSNLNSDGFGIGTPVGSDLRDKLNFSVLELRENGDLAK-WEKIWFDRGECPQHSSNKEGAQSALTLANVAGIFYILIGGLVVAVLSAAFEFLYKSRMDSRKSR 853          

Query:  413 DLKRHTFRIAANFNPPYITKVTE--------NCRSSRCFQGMFPDVWHALA---ETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNP-AESFNWTAFVEPLSWSCWGVIALFILVVPLGMSHAIKMGN----------DREKGEFTLSKSF----CF-VAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIW---TERIEP-----YIDGYPKTKI--GLSLKIIEETSNYALFDNFYTTITYEPYKK-CQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKY-----EAEKQICPDYSGKPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWSR 822
            D K +   +  N   P++    E         C+ +  F+G   D+   LA   E  NY   L        G+K  DGSW+GMIG+L         A  T+   R +VVDFS P   +   + +K P  + F+  +F++PLS   W    ++I+   +G+S  I + +          +  +G FT+S  F    C     A  + +G  + P SI  RI      FF++++  +     + A + +FL +     P  S+E++  ++  +  +Q G S    F+YS+  + Q++W     ++ P     Y +G  + +   G    ++E T+N            YE  +K C  + V      + +  A    S + D     +  ++ERG  K++  K+     + +  I  D S   L   +    F  LMGGMV+  ++ L E L   R  +R
Sbjct:  454 DHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIEEFNYEIKLGTKA----GSKQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIW----MYIIFAYIGVSVVIFLVSRFSPYEWRVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSS-----YTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSHKGRYAFLLEATAN-----------EYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKKLENKWWYDRGQCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEAR 887          

Query:  412 ADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPD-GSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCW--------GVIALFILVVPLG----MSHAIKMGNDR----EKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG------KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWSR 822
            + ++  T+ +      PY+   K       +  ++G   ++   +A+ + Y++ L    DG +G + PD  +WNGM+G+L     D+A A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W        GV  +  LV         S   + G D+    +  EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   + +++WT  +  EP +  + +T     +++ +    YA           E  K C  + V        +  A  K S   +     + K+ E+G   ++  K+  +K  C    G        L        F  L+GG+ L  +  L+E     RS S+
Sbjct:  402 SSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAF-MQQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV--FVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESK 837          

Query:  412 ADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPD-GSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCW--------GVIALFILVVPLG----MSHAIKMGNDR----EKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG------KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWSR 822
            + ++  T+ +      PY+   K       +  ++G   ++   +A+ + Y++ L    DG +G + PD  +WNGM+G+L     D+A A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W        GV  +  LV         S   + G D+    +  EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   + +++WT  +  EP +  + +T     +++ +    YA           E  K C  + V        +  A  K S   +     + K+ E+G   ++  K+  +K  C    G        L        F  L+GG+ L  +  L+E     RS S+
Sbjct:  402 SSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAF-MQQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV--FVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESK 837          

Query:  412 ADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPD-GSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCW--------GVIALFILVVPLG----MSHAIKMGNDR----EKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG------KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWSR 822
            + ++  T+ +      PY+   K       +  ++G   ++   +A+ + Y++ L    DG +G + PD  +WNGM+G+L     D+A A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W        GV  +  LV         S   + G D+    +  EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   + +++WT  +  EP +  + +T     +++ +    YA           E  K C  + V        +  A  K S   +     + K+ E+G   ++  K+  +K  C    G        L        F  L+GG+ L  +  L+E     RS S+
Sbjct:  402 SSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAF-MQQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV--FVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESK 837          

Query:  412 ADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPD-GSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCW--------GVIALFILVVPLG----MSHAIKMGNDR----EKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQIC--PDYSGK----PLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWSR 822
            + ++  T+ +      PY+   K       +  ++G   ++   +A+ + Y++ L    DG +G + PD  +WNGM+G+L     D+A A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W        GV  +  LV         S   + G D+    +  EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   + +++WT  +  EP +  + +T     +++ +    YA           E  K C  + V        +  A  K S         + K+ E+G   ++  K+  +K  C   D   K     L        F  L+GG+ L  +  L+E     RS S+
Sbjct:  402 SSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAF-MQQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV--FVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESK 837          

Query:  400 LSLKGLPIWERRADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGS-WNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCWGVIALFILVVPLGMS----------HAIKMGNDRE------KGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG------KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWS-RINRTVDDLNMKKSAIMHGISFAS 845
            ++L  LP     + L+  T  +      PY+   K  E    +  ++G   D+   +A+   + + L    DG +G +  D   WNGM+G+L   + DIA A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W  I    + V + +           H  +  + RE        EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   +  ++WT     EP +  + +T      ++ +    YA           E  K C  + V        +  A  K S   +A    + K+ E+G   ++  K+  +K  C    G        L        F  L+GG+ L  +  L+E     R+ + R+    +  N+  S+  +  +FA+
Sbjct:  397 VTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAF-MQQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV--FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFAT 868          

Query:  400 LSLKGLPIWERRADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGS-WNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCWGVIALFILVVPLGMS----------HAIKMGNDRE------KGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG------KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWS-RINRTVDDLNMKKSAIMHGISFAS 845
            ++L  LP     + L+  T  +      PY+   K  E    +  ++G   D+   +A+   + + L    DG +G +  D   WNGM+G+L   + DIA A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W  I    + V + +           H  +  + RE        EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   +  ++WT     EP +  + +T      ++ +    YA           E  K C  + V        +  A  K S   +A    + K+ E+G   ++  K+  +K  C    G        L        F  L+GG+ L  +  L+E     R+ + R+    +  N+  S+  +  +FA+
Sbjct:  397 VTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAF-MQQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV--FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFAT 868          

Query:  400 LSLKGLPIWERRADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGS-WNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCWGVIA---LFILVVPLGMS-------HAIKMGNDRE------KGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG------KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWS-RINRTVDDLNMKKSAIMHGISFAS 845
            ++L  LP     + L+  T  +      PY+   K  E    +  ++G   D+   +A+   + + L    DG +G +  D   WNGM+G+L   + DIA A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W  I    + + VV   +S       H  +  + RE        EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   +  ++WT     EP +  + +T      ++ +    YA           E  K C  + V        +  A  K S   +A    + K+ E+G   ++  K+  +K  C    G        L        F  L+GG+ L  +  L+E     R+ + R+    +  N+  S+  +  +FA+
Sbjct:  397 VTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAF-MQQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV--FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFAT 868          

Query:  400 LSLKGLPIWERRADLKRHTFRIAANFNPPYI--TKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGS-WNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWT-AFVEPLSWSCWGVIA---LFILVVPLGMS-------HAIKMGNDRE------KGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRII-----FFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWT--ERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG------KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWS-RINRTVDDLNMKKSAIMHGISFAS 845
            ++L  LP     + L+  T  +      PY+   K  E    +  ++G   D+   +A+   + + L    DG +G +  D   WNGM+G+L   + DIA A  T+T +R +V+DFS P       + +K P +S     +F++PL++  W  I    + + VV   +S       H  +  + RE        EF +  S  F  GA  + +G  ++P S+  RI+     FF++     ++   + A + +FL V   V P  S E++  +T+         S  + FR S   +  ++WT     EP +  + +T      ++ +    YA           E  K C  + V        +  A  K S   +A    + K+ E+G   ++  K+  +K  C    G        L        F  L+GG+ L  +  L+E     R+ + R+    +  N+  S+  +  +FA+
Sbjct:  397 VTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAF-MRQGCDISPRSLSGRIVGGVWWFFTL-----IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV--FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFAT 868          

Query:  371 IVLTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPIWERRADLKRHTFRIAANFNPPY-ITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVK-NPAESFNWTAFVEPLSWSCWGVIALFILVVPLGM---SHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSGKPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWSRINRT 826
            ++++EVY ++   P +    +GTW    GL+L  +  +ERR DL+    ++A+  +PP  + + T+N   +    G F +VWH+L + MN+T     P D AWG+   DGSWNGM+G + R E +I+ AEF +T LR++VVDF++P+ ++   + ++ N  +   W  F+EP S   W ++ L  LV+ L +   +H       R   E   S    +V G   + +G +        R+++    L    V+  + A +ISFL V+   LPF+S+ E+     +R+ V   ++++D F+ + + ++++++ + I P  D  P   I   ++ + +  NYA        +  +    C++ +V  A  P        K+SPY     Y L  M   G  K++ ++    K + P+   +PL     F++ + +   +  GF++ L+ +        R NR 
Sbjct:  110 VIISEVYNLNRDLP-LSRNYFGTWRQDVGLALTNISFFERRNDLQGIVMKVASMTDPPMSVVRKTDN---TLILGGFFGEVWHSLEQRMNFTSDCYIPEDRAWGSLTQDGSWNGMMGMILRGEAEISVAEFAMTVLRTRVVDFTVPLFDTRNCVLIRQNGDKDVIWHGFLEPFSPQLWMLVILTKLVIVLCLKTFNHIKLRFFGRMSSESPDSHCAVYVMGVFYM-QGVNRQTRFYSQRVLYLVAQLTALTVYTAYAAFLISFLTVQKFSLPFNSLRELIDIGSYRLGVLANSAHIDDFKNATDALMKEVYAKLIAPEEDHLP-ISIEEGMQRVCDIDNYAFMTTLEVALGLQNKITCKLSSVLGASIPESLTMTIAKRSPYRGLINYNLQAMFRSGTIKRLKQRSWPSK-LLPE---RPLWHSVDFSSILPIFAILGAGFVASLLLQTAEILVAGRRNRV 560          

Query:  371 IVLTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPI----WERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNP-AESFNWTAFVEPLSWSCW--GVIALFILVVPLGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPK-TKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQI 767
            ++L+EVY++   S K ++  + TW+  +GL  +G P+     +RR+DL+     +++   PP  T  +E+ R      G   DVW  L   MN+T  L   PD A+G+   +G+W GMI  L  +E+++A  +FTV  LR++VVDF++P +ES   +F+    +  F W+ F+ P S   W   +  +FI+ + L   H+ +   D   G     KSFC V  A+   +G +V P ++  R+++    L    +   + A ++S LAVR  VLPF+S E +  + D+ + V   ++ +  F  + + +L+Q++   I       P  +K GLS   + + S YA   +       +    C I  +  A+     + A +K SPY     + L K+++ G  K++
Sbjct:  157 VLLSEVYQV---SGKTQLRRFATWSRKSGL--RG-PVRDDFLDRRSDLQGTVINVSSVEGPPMTTVNSESDR----ITGFVGDVWAELERRMNFTTKLKVAPDNAYGSLTKNGTWTGMIALLVNNEVELAVGDFTVNNLRTKVVDFTVPFSESAVSVFIHGTGSRDFGWSDFLAPFSKELWLAAITVMFIMAICLVAIHSFECHKDTRHG-IGFLKSFCNVY-AIFCQQGVAVKPDALSRRLVYLGTCLTALTLSAAYSATLVSSLAVRINVLPFNSFETLLKRKDYHLGVVNNSAVLSEFEETTDYVLRQVYDTFIASKRSNLPADSKSGLSK--VCQNSKYAFVTSCLVATYMQNSLSCSIKPLPEAFTKEYLSLATKKNSPYLGVINHNLLKLRQDGTLKRL 547          

Query:   25 VLRTSADTISQIYGEEYLSSDRYFESGPFGGTQGGEWFTDFSQSLDGRTFRPTHWPDAINIRSGDRVDSIQMFYGPYHGGFHGGEGGTLQKFRLYDGNRIVRVTGRKGVGPGAGVDQLSFFTQDGQRFGPYGGIGGYYFESRPPQSDCYLAWISGRANFRIDSISFHWRC 194
            + ++   T+S I GE  L   ++F  G +GG +GG +FTD+  S D   + PT  P  INIR+G R+D IQ+ YG + G +HGG+GG L + RLYDG+ I+ VTGR G+GPG+GVDQL+F T++ + FGP+GG GG  F S PP+  CYL +ISG+++ R+D I FHWRC
Sbjct:   17 LTQSETKTMSDIQGELMLKDTQWFVPGSYGG-EGGVYFTDWWSSPDNSRYFPTRPPQQINIRAGGRIDGIQILYGGHKGAYHGGQGGNLHRIRLYDGDSIIAVTGRAGLGPGSGVDQLTFHTKNNKTFGPFGGTGGMPFRSVPPRPSCYLGYISGKSDLRLDKIVFHWRC 185          

Query:  371 IVLTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPI----WERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNP-AESFNWTAFVEPLSWSCW--GVIALFILVVPLGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPK-TKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYF 748
            ++L+EVY++   S K ++  + TW+  +GL  +G P+     +RR+DL+     +++   PP  T  +E+ R      G   DVW  L   MN+T  L   PD A+G+   +G+W GMI  L  +E+++A  +FTV  LR++VVDF++P +ES   +F+    +  F W+ F+ P S   W   +  +FI+ + L   H+ +   D   G     KSFC V  A+   +G +V P ++  R+++    L    +   + A ++S LAVR  VLPF+S E +  + D+ + V   ++ +  F  + + +L+Q++   I       P  +K GLS   + + S YA   +       +    C I  +  A+     + A +K SPY 
Sbjct:  111 VLLSEVYQV---SGKTQLRRFATWSRKSGL--RG-PVRDDFLDRRSDLQGTVINVSSVEGPPMTTVNSESDR----ITGFVGDVWAELERRMNFTTKLKVAPDNAYGSLTKNGTWTGMIALLVNNEVELAVGDFTVNNLRTKVVDFTVPFSESAVSVFIHGTGSRDFGWSDFLAPFSKELWLAAITVMFIMAICLVAIHSFECHKDTRHG-IGFLKSFCNVY-AIFCQQGVAVKPDALSRRLVYLGTCLTALTLSAAYSATLVSSLAVRINVLPFNSFETLLKRKDYHLGVVNNSAVLSEFEETTDYVLRQVYDTFIASKRSNLPADSKSGLSK--VCQNSKYAFVTSCLVATYMQNSLSCSIKPLPEAFTKEYLSLATKKNSPYL 482          

Query:  373 LTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNP-AESFNWTAFVEPLSWSCWGVIALFILVVPLGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYID--GYPKTKI-GLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSGKPLGFGQCFTAFIALMGGMVLGFISLLME 812
            LTEVY +H + P ++I   G W++  GLS   +P+  RR DL     + A     PYITK T        F G    +++     MN+T     PPDGA+G +  +G+WNG++G +  DE++   + F+    R  V+D+  PI      ++++ P A+    +    P +   WG +   +L + + +S    MG +RE  ++++   + +V G +   +G +  P     R +  +  L   +    + A  ISFL+VR   LPF+  + +     +R  V   T +V+ FR S++P+++QI+T+ +EP +     P+T + GL     +   +Y   D  +  +  E    C ++ V+ A+     +    K S Y   F + + +M+  G  K+ +    A K    + S  P+             GG+V   +S ++E
Sbjct:  158 LTEVYHVHPTLP-LQIFRIGNWSSVAGLSWSSVPLVRRRGDLHGTLIKGALRPQAPYITKTTYRDNKPIEFSGFSMRIFNEFRSRMNFTADCVVPPDGAYGFRDANGTWNGVVGMVATDEVEFGLSLFSFVKERMDVIDYLPPILSQKLVVYIRRPNAQQNTLSHISSPFTAPLWGAVVTAMLTLVVTLSVTWYMGPERENTDYSMKHCWFYVFG-IFCQQGQASAPAHWSCRAVCVTAYLTAVVTTAAYAATFISFLSVRRYSLPFADYDGLVRDGTYRFGVNRATGHVEFFRDSSDPVMRQIYTQLLEPEVRSIALPETDLEGLQRLCADGRYSYLTLDTSFKGL--EADIPCHVVEVARAFHTTTLSMIISKSSRYRALFSHHMQEMRRTGVLKRFVRSTWASKVEILEESLTPVSVDMITMLLTLPAGGVVAALLSFVLE 597          

Query:  272 SKGFPTSFVNYTQSGNLLQ-TAAPSLHVVFGHSGSFLEQTFSGTSNDDMIDANDFWLIQMPDVEDGRYNESQIVEAFDNVTLNYNSLTFLWSLDKSRPGWIVLTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFNWTAFVEPLSWSCWGVIALFILVVPLGMSHAIKMG---NDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEK---YEAEKQICPDYSGKPLGFGQCFTAFIALMGGMVLGFISLLMEKL 814
            ++  PT+ +  + S  L+Q T +  L V+     +FL         D M+     WL  + DV         + E   ++ + ++    +  L   +   + L EVY++   +P + +  +GT +   G       ++ RR  L  +  +  A+ N  Y+  V  +        G +  VW  L   +N+   ++ P  G WG+K  +G+WNG++G + R E ++  ++ T+T+ R  V+ +S+ +   H K+ ++    + +W  F+ P S   W  I ++++V+   +    ++G      E  + TL        GA+  ++G + TP S Q R+++      G ++F  + A ++SFLAV    LP ++++++     + +    G+S ++ FR S       ++ ER++P++   P+  +   L+ +     YA       T+ Y P+  C+++ +    F +++A+ F   SPY   F Y L K+ E G  +++ +    YE  K    + + K +        F     G+V+    + +E+L
Sbjct:   12 TRNIPTAELRASSSPQLMQCTKSRQLAVLLAAEPAFLSSVLENCKRDKMV-----WLAFL-DVGQS------LKELVGDLNIRFDVQFLVVQLADIK---MQLFEVYRVAPDTP-LRVQLFGTRD---GPLHSPAHVYHRRRSLGGYVMK-TASLNNSYLVSVNNDI-----IGGFYGKVWAVLERHLNFKSTVSVPATGLWGSKDDNGAWNGVVGMVTRREAEVGVSDVTMTSDRVGVLSYSMQVATFHYKVVIRAGEVNVSWDNFLRPFSTGLWTAITIYVVVMAFALKIYFEVGLVQGKEEPRDQTLQDWLLATFGAVFCSQGQASTPLSFQCRLVYILSYTLGFVIFCAYSAAVVSFLAVHDAKLPVTNIQQLQKDESYTIRTVNGSSTLEAFRQSTAHDFMTLYKERLKPHLADMPRNVLE-GLQRVCRERRYAFMVPKEETLEYLPHLSCEVVYLPQGIFEMKYAFVFNVDSPYIGLFRYTLQKLLETGIMEKLHQDTMIYEPRKS---EGAFKSMELVDVVPVFSISTSGIVVAIFLVFLEQL 532          

Query:  371 IVLTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESFN-WTAFVEPLSWSCWGVIALFILVVPLGMSHAIKMGNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYI--DGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQ 754
            + LTE+Y IH + P +++   G W++ +GL+    P+ +RR DL     + A     PYIT+     +    F G    ++      MN+T     P DGA+G +  +G+W G++G +  DE++I    F+ T  R  V+D+  PI       +++ P++ +  W+  + P     W  +   +L + + ++     G +R+K +++   SF  V GA +  +  ++ P ++ +R+++  + +   ++   + A  ISFLAVR   LPF   E +     +R+ +   T ++  F+ S++P+++QI+T+ IEP +  +  P+T +    K+ +E S Y+      +    E    C I+A+  A+     +    K S Y   F  Q
Sbjct:  268 VSLTELYHIHYALP-LQMFFIGNWSSVSGLTWSSAPLSQRRRDLHGIVIKGALRPQAPYITERKYKNKKPIEFGGFTMRIFREFESRMNFTPEYFIPRDGAYGFRNANGTWTGIVGMVATDEVEIGIGLFSFTEGRMDVIDYLPPILNPKLTAYIRQPSDEYTMWSHILSPFGVPLWRALVTVMLTLMVALTATWYFGAERDKTDYSFKTSFFLVLGAFS-QQSHAIAPKTLSSRLVYLMVYVTAVIMTTSYAATFISFLAVRRYKLPFEDFEGLLKDGSYRLGLNRATGHLHLFQDSDDPLMRQIYTDLIEPEVRSNALPQTDLEGLRKLCDE-SKYSFLTLDTSLKGLEKEIPCNIVAIPRAFHTTTLSMLISKSSSYRTLFTDQ 651          

Query:  366 SRP---GWIVLTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQ--GMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPAESF--NWTAFVEPLSWSCWGVIALFILVVPLGMSHAIKMG-------NDREKGEFTLSKSFCFVAGAMT-IARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTF-RYSNNPMLQQIWTERIEPYI-DGYPKTKIGLSLK--------IIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGAT-KQILEKYEAEKQICPDYSGKPLGFGQCFTAFIALMGGMVLGFI----SLLMEKLMPQR 818
            +RP   G ++ TEVY I  +  +++ L  G W+   G S   +  + RR+DL+  T   AA  +   I ++TE  R+++  Q  G F  +W+AL   +N+T     PPDG +G++  +G W+GMIG L R E ++A   + +T L    V F  P+  +   +FV+ P  SF   W  ++ P S   W  +   IL +  G++  + +G       NDR     +L  SF ++ G++     GW+   WS   R++F S  L   ++   + A  ISFL VR + LPF++ E +     F++ +   +  +  F + +   ++Q ++ + I P + D  P T  GL           +++ T  Y++ +N            C I+A+  A+ P    +   K SPY     + L +M+  G   +  +    ++       +   + FG+    F  L   +VL  +     L M + MP+R
Sbjct:   99 ARPTESGTVIFTEVYHIRRNQ-RLQKLNLGEWHHERGPSWTNISFYTRRSDLQGATLN-AAVISDGAICRITE-FRNNKPVQVGGFFGVLWNALRYQLNFTSEFMKPPDGGYGSRGKNG-WSGMIGMLVRKEAEVAVGAYVMTQLLLDHVHFVSPMGATKVAVFVRRPGPSFGTTWDTYMAPFSNKLWMAVLCAILGLSFGLTVTLSIGCRIGIEKNDRTT-HLSLYDSFIYIFGSVCQQGHGWT---WSWPCRLVFLSASLAAVVLLAAYSATFISFLTVRHSSLPFTTFEGILQDGTFKLGILERSVELSFFDQTATETVMQNVYNKLILPALEDAPPDTLAGLQRVCDQPKYGFVVDSTRAYSVLNNL----------TCDIVALPEAFIPATGTFVVAKHSPYRRLINFNLEEMRRHGELGRMFVHAMPSKISGTSSTTLIKVRFGEVVPVFAVLSASLVLASVLLATELCMHRNMPRR 563          

Query:  371 IVLTEVYKIHMSSPKIEILPYGTWNASTGLSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNP-AESFNWTAFVEPLSWSCWGVIALFILVVPLGMSHAIKM----GNDR---------EKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQ 776
            + LTEVY++  S P + +  YG W     LSLKG   ++ R +L+  + R  +  N PY     EN  SS   +G    +W  + ET+N+T       D   G+   +GSW G+IG L R EID+A +  T+T +R++VVDF+LPI  +  KLF++ P A   +W  F+ P   S W  I + I VV + +    ++    GN           +   F +  +FC        ++G  +T  ++  R++F +  +   ++   + A +IS L ++T  LPFS+ EE+       V V   ++ +  F  + +P+L++++TE I    + +P T +    ++   +  +A                C+I+ +      V  A AF K +PY D   + L  M+  G  +++   Y  + Q
Sbjct:  146 VQLTEVYRVTSSHP-LTLRHYGVWKQDHPLSLKG-NFYDGRNNLQGLSMRAISMNNLPYSVMEMEN--SSYKLRGSIAPIWRMMEETLNFTTEYQFSEDNFAGSLADNGSWRGLIGVLSRQEIDVAVSAITMTPMRTEVVDFTLPIFLNSYKLFIRQPNAVDVDWGNFLAPFHSSLWLSILVIIFVVSVLVEACHRLVQRFGNSSAEWQHRPFFQDSLFHVFSAFC--------SQGHDMTYRTMSIRVLFLAAHMTAVVLLAAYSAGLISSLTMQTMNLPFSTFEELLNDGTHAVGVVNNSAAIWLFSETKDPLLREVYTELIASDPENFPSTTLEGMRRVC--SIKFAFLSQMSRVQNIRHDIPCKIVDLPATSITVNLAIAFTKGNPYRDVINHNLRGMRRAGILQKLQLDYGTKGQ 551          

Query:  345 EAFDNVTLNYNSLTFLWSLDKSRPGWIVLTEVYKIHMSSPKIE----ILPYGTWNASTGLSLKGLPIWERRADLKRHTFRIAANFNPPYITKVTENCRSSRCFQGMFPDVWHALAETMNYTFFLNPPPDGAWGTKLPDGSWNGMIGQLYRDEIDIAPAEFTVTALRSQVVDFSLPITESHQKLFVKNPA--ESFNWTAFVEPLSWSCWGVIAL--FILVVPLGMSHAIKM-------GNDREKGEFTLSKSFCFVAGAMTIARGWSVTPWSIQNRIIFFSIMLGGTLVFWHWEAMIISFLAVRTTVLPFSSMEEMFTKTDFRVAVQPGTSYVDTFRYSNNPMLQQIWTERIEPYIDGYPKTKIGLSLKIIEETSNYALFDNFYTTITYEPYKKCQIIAVSVAYFPVQFAYAFQKKSPYFDAFWYQLNKMKERGATKQILEKYEAEKQICPDYSG-KPLGFGQCFTAFIALMGGMVLGFISLLMEKLMPQRSWS 821
            E F NV +  +   FL +  +     I+++EVY +    P  +    IL +G W     ++L  +  +ERR DL+  T ++A    PP     T + R     +G F  VW  L + MN+T     P D AWG+   +GSWNGM+G + R E +IA AEFT+TALR++ VDF++P+  +   + ++  +  +   W  F++PLS   W ++ L   ++++ L +   +K+        + R+ G F       F    + +  G+         R+++    L    +   + A +IS L V    LPF S+ E+     +R+ V   +  ++ F  + + ++++++ + I P  D  P   I   ++ + + + YA   +    +       C++ +V  A  P   A +  K+SPY     ++   M   G  K+ L   E   ++ P      P+           L G +++  + L  E+L+ +R  S
Sbjct:  144 EFFHNVYIPLDC-HFLVAHSQGPDNIIIISEVYHVTRDLPLAKNYFGILSHGAW-----VTLATISFFERRNDLQGMTMKVATMTEPPVTIVKTVDGR--LVLEGFFGKVWQVLEKRMNFTSEFIMPADRAWGSLAHNGSWNGMMGMIVRGEAEIAVAEFTMTALRAEAVDFTVPLINTRNCVLIRQISGEKDPTWYGFLKPLSSQLWALVILTQLVIILCLNVVRRLKLRCLGRKSSDSRDDGHFAAQIVGIFFLQGVNVKTGFC------SERVLYLVAQLSALTIHTAYAAFLISCLTVHKFSLPFDSLRELIDIGTYRLGVLANSGQLNIFNNATDDLMREVYAKLIAPDKDNLP-ISIEEGMQRVCDVNCYAFMTSLDVVLGLLDNITCELSSVLGASIPESLAMSAIKQSPYLGLINHK--AMFRSGVLKR-LRAQEWPTELPPATVLWVPVDLPSTLPFLAVLGGALLVSALLLTAERLLGRRRQS 618