endoprotease furin, snap_masked-scaffold298_size217389-processed-gene-0.1 (gene) Tigriopus kingsejongensis
|
Overview
Associated RNAi Experiments
Nothing found Homology
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000000132 (supercontig:LSalAtl2s:LSalAtl2s1021:129587:131575:1 gene:EMLSAG00000000132 transcript:EMLSAT00000000132 description:"augustus_masked-LSalAtl2s1021-processed-gene-0.9") HSP 1 Score: 783.482 bits (2022), Expect = 0.000e+0 Identity = 382/603 (63.35%), Postives = 447/603 (74.13%), Query Frame = 0
Query: 20 YHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDLS-------------------------------DSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEV-NHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR 590
Y N FA++IP+G+ A+ +A GF+N G IGTL N+FLF+H + R T+ + H L P V WFEQQ E++R KRD + +DP+F QW LN GA +G DMNV+PAW +GY+G VVVTILDDGIQ +HPD NYDPLASTDIN ND DPMPQDN +NKHGTRCAGEVAA A NG+CGVGIAYNASIGGVRMLDG+VNDAVEARALSLNP+H+DIYSASWGPEDDGKTVDGPGPLAK+AF+NGV GR GKGSIFVWASGNGGR DNCNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPG D SI+TVDQDARLR + +CT+ HTGTSASAPIAA VCALALEANP+LTWRDMQ++VV+TS PL ESGW +N GR YSH+FGYGLMDA MV A W +Q IC+T + ++ IP + G AR +++TD CSGT + YLEHVQCKISL Y+PRG L I+LTSPSGTKS+LL PRP+D F+DWPFLSVHF+GE GTW LEV N S SG +G++KKW+++FYGT +P+R
Sbjct: 25 YQNQFAVYIPKGKVVADTLAQEYGFENIGQIGTLDNYFLFKHSRINKRSTDAATLHAIFLTLNPEVKWFEQQKEKKRVKRDFNVWSPVFDSQSTGTTLTSSSIGKRQGFRFVXEPRNLFADPIFTYQWHLNAGARNGFDMNVKPAWKRGYSGTGVVVTILDDGIQMNHPDXISNYDPLASTDINDNDADPMPQDNGNNKHGTRCAGEVAASANNGVCGVGIAYNASIGGVRMLDGVVNDAVEARALSLNPDHVDIYSASWGPEDDGKTVDGPGPLAKRAFLNGVVRGRQGKGSIFVWASGNGGRHSDNCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGRDGSISTVDQDARLRSEYLCTSEHTGTSASAPIAAAVCALALEANPSLTWRDMQYLVVMTSRSNPLKDESGWAINGAGRSYSHQFGYGLMDADHMVRAAVGWKALPQQHICQTPIMVPNIQIPDSYGIPARASIQTDGCSGTINSVNYLEHVQCKISLKYYPRGNLMIMLTSPSGTKSTLLFPRPKDNFATSFQDWPFLSVHFYGEIVPGTWKLEVLNMGSSAPLRSG--QGLLKKWQLIFYGTENNPIR 625
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000012868 (supercontig:LSalAtl2s:LSalAtl2s97:2839025:2843929:-1 gene:EMLSAG00000012868 transcript:EMLSAT00000012868 description:"augustus_masked-LSalAtl2s97-processed-gene-28.2") HSP 1 Score: 744.577 bits (1921), Expect = 0.000e+0 Identity = 480/1203 (39.90%), Postives = 606/1203 (50.37%), Query Frame = 0
Query: 15 GHGKIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHE--ILIKEPGVHWFEQQHERRRFKRD----LSDSMYI-SDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAK-GIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNN--GQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCS-NDQKCIKCQAGWSFANEK-EACSPQANAQCPEGSF---KTRSCDPCHESCATCTGNLSTQCSLC-LDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTC--ESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSL 1198
G YHN FAL IP G+ RI GPI L+++ LFE + R SLE HE ++ + W+EQQ E+ R KRD +D+++ SDPLF+ QWFLN GA DGSDMNV AW G TGK VVVTILDDGIQT+HPDL NYDPLASTDIN ND++PMPQD+ DNKHGTRCAGEVAA AFN CGVG+AYNASIGGVRMLDG+VNDAVEARALSL PNHI IYSASWGPEDDGKTVDGPG L K+AFI+G+ GR G+GSIFVWASGNGGR+ DNCNCDGYTNSI+TLSISSA+QGG KPWYLEECSSTLASTYSSGTP HDASI TVDQD + + G S G+ L W+ L+ + + K++P + S+ V + K + +LEHVQ IS+ PRG+L +VL SPSGT+S LL+ R +D +G FEDWPFLSVHFWGE G WTLEV ++ + K G++K W+++FYG +PLR NV NN+ G+ V E+ + + E +S C S +C C++F F N CVE+CP T+ + +G C+ CH C TC GP NQCLTC+ L + S C K CP + N C+PC ++ ++C L +TT C+ C G + E+ C CP GF + + C CH C C G +QC C DG FY E C+ CP+ + + +EC PC +GC C + +KC KC+ W K P CP GS+ K C CH C C G C C D F+ C+ CP+ Y +C CP C +C+ ++C C +G ++ A+CP+G F C PC C +C K + C+SC + V CP+G F Q ECR C C TC + +C C GS C A G Y CL C+ SC C G +NECLSC + + E+C D+N C+ C+ S C P+L
Sbjct: 19 GREVYYHNQFALRIPSGDPY--RIGQRHDLNYIGPI--LNDYHLFEVHHIHRR----SLEPHEDHQFHEDEDITWYEQQIEKNRIKRDNDVERTDTIFQPSDPLFERQWFLNQGAHDGSDMNVVEAWKLGITGKGVVVTILDDGIQTNHPDLIDNYDPLASTDINDNDDNPMPQDDGDNKHGTRCAGEVAAIAFNDYCGVGVAYNASIGGVRMLDGVVNDAVEARALSLRPNHIHIYSASWGPEDDGKTVDGPGRLTKEAFISGILKGRSGRGSIFVWASGNGGRRDDNCNCDGYTNSIYTLSISSATQGGYKPWYLEECSSTLASTYSSGTPSHDASITTVDQDG----ESGWYVNGVGKHYSHKFGYGLMDAGTMVKSALNWK-------------------------------------LVGPQMVYKSEKIYPNK-----------------TLRKESLGEVVYAFIYIKESNKLMNHLEHVQAVISITGSPRGSLELVLISPSGTRSILLMKRSKDTRDGSFEDWPFLSVHFWGETPTGKWTLEVIRHEDIQPENNNRKDGVLKDWQLIFYGVEGNPLRD--------------------------------NVRANNSNLGEQVE-------------SYDEYEGLSNDTVGVEVSTSDC-----------DNSEKCLKCKSFIFNNNCVENCPNKTFPA-QGYCKPCHFKCNTCYGPQLNQCLTCTVPYLFLPESSSCHK-VCPXSHFLEKDYNICLPC-FNFKNC------------------LQCHQTTGNCILCNTGFFVTP-ESYCSPYCPSGFYSDSKENQCSTCHTVCEECFGPKQSQCISCKDGKFYHERTCLEKCPSSHYENKDLKECTPCSKGCLECPLHPRKCQKCEENWILLGNKCFPAIPNKKTSCPMGSYYDLKKLECSSCHYQCQNCFGRGPDHCITCNKDNPFHHISSCLHTCPS-YFTYPEGLQCNHCPHSCRSCTGAKQCNLCNSGSVLTSDGRCV-----AKCPQGYFPSIESLKCEPCHRNCKSCIGIKENECISCVDSFVHAPDGSCRSTCPDGFF--LQEGECRPCHGRCKTCFGQENDNCLSCFKGLLFEGS-TCWACKSGEYYDDIAAKCLKCHLSCRQCFGDLANECLSCNNHRAFNKWNNTCEKCC--MTDENDCCE-CNKSKTICVNPNL 1065 HSP 2 Score: 258.84 bits (660), Expect = 3.762e-70 Identity = 188/609 (30.87%), Postives = 272/609 (44.66%), Query Frame = 0
Query: 805 CLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYF--EHKCVPDCPAGYRPDVHHQECVPCP--QGCHTCSNDQ-KCIKCQAGWSFANEKEACSPQANAQCPEGSF---KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCS-NDQKCIKCQAGWSFANEK-EACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKA-DNCLSCPKNHVLD-LSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGL-CLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCESSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFG----LGDEALTNPSRSLFHYGSLLAILALMTLVIVKYFKRAKIRLYAMNGSRARRHHQRRRQTSQD-LSGTNYQKLLKDEQPADGPLNFNRNAR 1395
CLKC+ + N C+ CP P C PCH C TC G QC C + C CP + + + C+PC + C C CI C G+ F + CSP CP G + K C CH C C G +QC C DG FY E C+ CP+ + + +EC PC +GC C + +KC KC+ W K P CP GS+ C+ C C CF + D+C++C K++ +SSCL H CP+ Y L +C HCPH+C +C C+ C LT G+C A C + + L C C+R+C++C+G NEC+SC + G C C GF + +C+ CH C C G C +C G L + C +C+ +++D + +CL CH SC C G N CLSC+ + WN TC CC +DE CC C S+ C+ P+ SRKRSS G L + + +F+ + ++ +V+V + +R + + SR H+Q + + D +S Y +E P ++ N R
Sbjct: 579 CLKCKS----FIFNNNCVENCPN--KTFPAQGYCKPCHFKCNTCYGPQLNQCLTCTVPYLFLPESSSCHKVCPXSHFLEKDYNICLPCFNFKNCLQCHQTTGNCILCNTGF-FVTPESYCSPY----CPSGFYSDSKENQCSTCHTVCEECFGPKQSQCISCKDGKFYHERTCLEKCPSSHYENKDLKECTPCSKGCLECPLHPRKCQKCEENWILLGNKCFPAIPNKKTSCPMGSYYDLKKLECSSCHYQCQNCFGRGPDHCITCNKDNPFHHISSCL-HTCPSYFTYPEGL-QCNHCPHSCRSCTGAKQCNLCNSGSVLTSDGRCVAKCPQGYFPSIESLKCEPCHRNCKSCIGIKENECISCVDSFVHAPDGSCRSTCPDGFFLQEGECRPCHGRCKTCFGQENDNCLSCFKGL-LFEGSTCWACKSGEYYDDIAAKCLKCHLSCRQCFGDLANECLSCNNHRAFNKWNNTCEKCC-MTDENDCCECNKSKTICVNPNLNN-SRKRSSYTIGRSYQLNNNQMKRNESGIFY---IFTASTILFVVLVYFIRRNRYKC----RSRFYNHYQGYTKVAYDNISDHVYLSNESNENRFIRPALYDFNQR 1164 HSP 3 Score: 127.487 bits (319), Expect = 1.222e-29 Identity = 108/379 (28.50%), Postives = 159/379 (41.95%), Query Frame = 0
Query: 897 CSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS-CDPCHESCATCTGNLSTQCSLCLDGTFYF--EHKCVPDCPAGYRPDVHHQECVPC--PQGCHTCSNDQ-KCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCE-SVSSCSQCGLDHFLTGS-------GKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFV-DKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLS-CEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLV 1258
C N +KC+KC++ + F N CP +F + C PCH C TC G QC C + C CP + + + C+PC + C C CI C G+ F + CSP CP G +S + C+ C + C CF K C+SC +CL+ +CP+ + + L EC C C+ C C +C + L G+ K ++ G+ Y C +C+ C+ C G + C++C CL C F + QC C SC +CTG QC+ C SG+ L C++ C F S +C CH +C +C G ++N C+SC V
Sbjct: 573 CDNSEKCLKCKS-FIFNN-------NCVENCPNKTFPAQGYCKPCHFKCNTCYGPQLNQCLTCTVPYLFLPESSSCHKVCPXSHFLEKDYNICLPCFNFKNCLQCHQTTGNCILCNTGF-FVTPESYCSP----YCPSGFYSDSKENQCSTCHTVCEECFGPKQSQCISCKDGKFYHERTCLE-KCPSSHYENKDLKECTPCSKGCLECPLHPRKCQKCEENWILLGNKCFPAIPNKKTSCPMGSYYDLKKLECSSCHYQCQNCFGRGPDHCITCNKDNPFHHISSCLHTCPSYFTYPEGLQCNHCPHSCRSCTGAK--QCNLCNSGSVLTSDGRCVAKCPQGYFPSIESLKCEPCHRNCKSCIGIKENECISCVDSFV 935
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000007470 (supercontig:LSalAtl2s:LSalAtl2s427:85085:93720:1 gene:EMLSAG00000007470 transcript:EMLSAT00000007470 description:"maker-LSalAtl2s427-augustus-gene-1.11") HSP 1 Score: 468.003 bits (1203), Expect = 2.300e-148 Identity = 251/497 (50.50%), Postives = 321/497 (64.59%), Query Frame = 0
Query: 108 SDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDN--SDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKI--------CTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITS--NPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLH-YHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGG---FEDWPFLSVHFWGEPANGT----WTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGT 584
+D + + W+LN G D DMNV+ AW GY+GK VVTILDDG++ DHPDL NYD AS D+N D DP P+ + + NKHGTRCAG++AA A N C VGIA+NA +GG+R+LDG + D++EA+ALS N ++IDIYSASWGP+D G TVDGPG LAK+A +G+KFGR GKGSIFVWASGNGG+K D+CNCDGY+ SIFTLS+SS S+ G PWY E C+S+LA+TYSSG + RLR KI CT SHTGTSAS+P+A + AL LEANPN+TWRD+QHIVV+T+ + L+ W VN GR++SH +G+GLMDA AMV++A W Q IC + + + + S CS +EI+ LEH+ I L RG L + LTSPSGT S LL RP D G F +WP +SVHFWGE WTL+V + +G+A +K+WK+ FYG+
Sbjct: 246 NDRFWPEMWYLNRGG-DHLDMNVEEAWEGGYSGKGXVVTILDDGVEWDHPDLIDNYDENASADLNDRDGDPYPRYDIINSNKHGTRCAGQIAAAANNSYCSVGIAFNAKVGGIRILDGRIFDSLEAQALSYNRDYIDIYSASWGPDDXGATVDGPGVLAKQALEDGIKFGRKGKGSIFVWASGNGGKKSDDCNCDGYSTSIFTLSVSSTSENGFIPWYSESCASSLATTYSSGA-----------SNRRLREKKIVTTDLHGSCTKSHTGTSASSPMAXALIALTLEANPNMTWRDVQHIVVLTARGSAGSYLKSDDWSVNGAGREFSHSYGFGLMDADAMVKLAANWTNIPEQMICHSSEVIYENGLVGEQDSEIESKTNASLCS---EEIKSLEHIHLFIDLDSTSRRGDLSVSLTSPSGTTSRLLNFRPFDDERVGFASFNNWPMMSVHFWGENITNKDLDEWTLKV-----INRGNGVAS--LKRWKLRFYGS 720
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000011906 (supercontig:LSalAtl2s:LSalAtl2s83:633334:637253:1 gene:EMLSAG00000011906 transcript:EMLSAT00000011906 description:"maker-LSalAtl2s83-augustus-gene-6.18") HSP 1 Score: 393.66 bits (1010), Expect = 1.608e-120 Identity = 252/622 (40.51%), Postives = 335/622 (53.86%), Query Frame = 0
Query: 35 ANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGV-HWFEQQHERRRFKRDLSDSMYI----------SDP---------------LFKDQ---------WF--LNHGAFDGS------------------------DMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSD--NKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDG-LVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESG---WRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMT-NGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSP 588
A+ IA GF N G I N + F + L T S+ H L +P V H F+Q +R + LS SM I +DP L KDQ ++ L H GS D+NVQ AWA+G TGK V I+DDG L + AS D + ND P P+ D N HGTRCAGEV+ NGICGVG+AY++ + G+RMLD + D +EA ++ PN IDIYSASWGP DDG+TVDGP +A + GV GR+GKG+I+VWASG+GG + D+CNCDGY S++T+SI+SA G+ Y E CSSTLAST+S+G + +AT D + CT +G SA+AP AAGV ALALEAN LTWRDMQH+ V+TS L G W +N VG +++H FG+G++DA AMV +AK W + C+ + IP S S+ +T++TDAC+G E+ YLEHVQ I+++ RG + + L SP GT+S +L RP D GF WPF++ H W E G WTLE L +G +K+W ++ +GTR +P
Sbjct: 118 AHNIARRNGFVNVGTILGSPNEYHFVNHALPQARTKRSVPHIRKLKADPLVEHAFQQSGFKRDKRYGLSRSMRIQNQKQKPRNVNDPWPYLRQALDKPQKRALSKDQDSNVIHDENFYNRLQHSKSTGSKRGYNPLRVENLKNDGQNGGKPKLDLNVQAAWAQGVTGKNVTTAIMDDGTT-----LFLVNNARASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSGARDNGICGVGVAYDSMVAGIRMLDQPYMTDLIEANSMGHEPNLIDIYSASWGPTDDGRTVDGPRNATMRAIVRGVNEGRNGKGNIYVWASGDGGEE-DDCNCDGYAASMWTISINSAINTGENAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGK------CTRXXSGXSAAAPEAAGVFALALEANRQLTWRDMQHLTVLTSKRNSLFDSKGRFHWTMNGVGLEFNHLFGFGVLDAGAMVALAKQWKTVPARYHCQAGSDKTVREIP-GSKSLF-LTIETDACAGKDTEVNYLEHVQAVITVNSTRRGDVELFLRSPMGTRSMILSNRPNDDDGQDGFTKWPFMTSHTWAEYPRGKWTLEARF-----HGERLNRGFLKEWTLMLHGTRDAP 720
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000007363 (supercontig:LSalAtl2s:LSalAtl2s418:9796:10997:-1 gene:EMLSAG00000007363 transcript:EMLSAT00000007363 description:"maker-LSalAtl2s418-augustus-gene-0.2") HSP 1 Score: 335.495 bits (859), Expect = 4.311e-104 Identity = 177/334 (52.99%), Postives = 223/334 (66.77%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLR---PRCTNHS--LEHHEILIKEPGVHWFEQQHERRRFKRDLSD---------SMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDN--SDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTY 335
KIY N + LH+P+G A +A G + + N ++ + +R R + L +I+ ++ V W EQ R KR+ S S ++DP + W+LN D +MNV+ AW +G TGK V TILDDGI+ +HPDL RNYDPLASTDIN ND DP P+ + + N+HGTRCAG+VAA N +C VGIAYNA IGG+RMLDG V+DAVEAR+LS NP+H+DIYS+SWGP DDGKTVDGPG LA +AF NGV GR GKGSIFVWASGNGGR DNCNCDGY SI+T+++SS S+ G+ PWY E C+STLA+TY
Sbjct: 44 KIYLNEWTLHLPKGLESAITLASKRNLILLGEV--IPNSHIYHFQSVRRGHKRSKRQASWLSRRKIM-QDKSVTWGEQCTVVSRVKREGSKNQRRRHQHFSYEMNDPYWHKMWYLNRE--DDLNMNVEGAWEQGVTGKGVAXTILDDGIEKBHPDLLRNYDPLASTDINDNDSDPNPRYDFSNSNRHGTRCAGQVAASPNNSLCAVGIAYNAQIGGIRMLDGQVSDAVEARSLSFNPDHVDIYSSSWGPNDDGKTVDGPGKLAHRAFHNGVTRGRSGKGSIFVWASGNGGRFKDNCNCDGYATSIYTITVSSTSESGRIPWYSEACASTLATTY 372
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000007238 (supercontig:LSalAtl2s:LSalAtl2s406:251464:253084:1 gene:EMLSAG00000007238 transcript:EMLSAT00000007238 description:"maker-LSalAtl2s406-augustus-gene-2.34") HSP 1 Score: 311.227 bits (796), Expect = 9.432e-94 Identity = 182/484 (37.60%), Postives = 262/484 (54.13%), Query Frame = 0
Query: 109 DPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDG--LVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTP-GHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRE-SGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSP 588
DPL+KD W L + D MN+Q AW++G +GK V V LDDGI HPDL NY P S D ND DP+ N HGT+ +G V +E N CG+GIA++A +G R+ + + RAL+ + IDIY+ + GP++ G T+D P + + GR GKGS+ + A GNGG + C+ SI T+++++ + G P Y E C + + S + S P G TV + C + +GTS+S +A GV AL LEANPNLTWRD+QH+V+ + +L + + W+ NA G +S FG+GLMDA M A W Q +CE + I S V ++L TD+C +I+YLEHVQ + + + RG +++ L SPSGT S++L R D + GF DW LS+ +WGE + G W L V SP + + + K WK++ YGT++ P
Sbjct: 22 DPLWKDSWHLRN---DNISMNIQDAWSRGLSGKGVRVLFLDDGIDRYHPDLYTNYKPELSYDFVDNDNDPIWNRTLKNSHGTKMSGIVGSEGNNSFCGLGIAFHAQLGMARIFNKNVIFEHLNVVRALTYKKDLIDIYTIAVGPQNMGVTLDNV-PEEINEALKETENGRGGKGSLVLLAXGNGGANNEACSFGSNLQSIHTIAVNAVGEEGDIPDYAEPCGAVMTSAFGSSKPRGRGIVTTTVGGN--------CVGNFSGTSSSTAVATGVIALVLEANPNLTWRDVQHLVMSSVVDRDVLDDKANWKRNAAGIYFSEFFGFGLMDAGLMTRRANEWIQVPTQIMCEYKDPQENKII---SEEVVELSLSTDSC-----DIQYLEHVQLQFTAYSLCRGNINLRLESPSGTLSNILRGRETDFSTTGFNDWRLLSLQYWGESSKGKWRLRVFKSPCINRAAKIIA--FKSWKLILYGTKEMP 483
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000009225 (supercontig:LSalAtl2s:LSalAtl2s588:280841:284110:-1 gene:EMLSAG00000009225 transcript:EMLSAT00000009225 description:"maker-LSalAtl2s588-snap-gene-3.14") HSP 1 Score: 307.76 bits (787), Expect = 7.942e-90 Identity = 169/336 (50.30%), Postives = 204/336 (60.71%), Query Frame = 0
Query: 17 GKIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKR-----------------DLSD----------------------SMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQ-DNSD-NKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSI 311
G Y N FA+ + G +A+R+A L NRG + + + F H +R R H +L +HW+EQQ R KR DL D S+Y + W+LN G DMNVQ AW G TGK V VTILDDG++ HPDLR+N+DP++S D+N ND+DP P+ D SD NKHGTRCAGEVAA A N ICGVG+AY A IGG+RMLDG V DAVEA +L + HIDIYSASWGP+DDG TVDGPG LA+KAF+ G+ GR GKGSIFVWASGNGGR +NCNCDGYTNSI+TLS+
Sbjct: 18 GISYTNEFAVQVRGGSHEAHRLAQELDCINRGHL--FDDIYRFTHTRIRKRSIQIHSNFHSLLTNHSRIHWWEQQRVLSRKKRQIWAMPAPPQESQYPRGDLIDLARLNDERXVRFFLDVKIGCKSSLYYYLNRWNQMWYLNRGG--KVDMNVQKAWEFGATGKGVHVTILDDGVERSHPDLRQNFDPMSSFDVNDNDDDPTPRYDISDSNKHGTRCAGEVAATANNSICGVGVAYEAGIGGLRMLDGDVTDAVEAHSLLFHNQHIDIYSASWGPDDDGLTVDGPGTLAQKAFMKGIAEGRGGKGSIFVWASGNGGRHXBNCNCDGYTNSIWTLSV 349 HSP 2 Score: 146.362 bits (368), Expect = 6.122e-36 Identity = 105/332 (31.63%), Postives = 148/332 (44.58%), Query Frame = 0
Query: 408 LRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYV---SLRGTCQACHSSCQTCSGPNPNQCLTC 736
++ W NAVGR +SH FGYG+MD MV++AK W Q + + + ++ S A T+ G I+YLEHVQ +++ RG + I + SPSGT+S LL RP+D + GF DWPFL+VHFW E GTWTLEV S G + +++W + YGT P Q L + S +P K+ S N S N V Y + PQ CS + E + N + C + CP + Y +++ TC C+ SC+TCSGPN +C +C
Sbjct: 349 VKPRNWDTNAVGRNFSHSFGYGIMDXHCMVKLAKNWVSVPTQLQADI-AGDRRVDVSIHGKSKATSTMNVKDTRG----IKYLEHVQVHVTISAARRGDIIIYIISPSGTRSKLLARRPKDYSQMGFNDWPFLTVHFWEESPFGTWTLEV-------SNDGRSMVQLRRWSLTLYGTSGHP--QQSLTESTIKVSSTVASVDIPEKLKPSS-----NDSSNGKNPQV----------------------------YLNNCVEIDPQVALGWCSSCE--EGFILHNGR----CEKTCPQSYYAGVSNMKPTCVPCYYSCKTCSGPNDYECTSC 627
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000003323 (supercontig:LSalAtl2s:LSalAtl2s182:344829:368713:-1 gene:EMLSAG00000003323 transcript:EMLSAT00000003323 description:"maker-LSalAtl2s182-augustus-gene-4.24") HSP 1 Score: 172.555 bits (436), Expect = 3.101e-46 Identity = 97/213 (45.54%), Postives = 127/213 (59.62%), Query Frame = 0
Query: 313 SASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVW----PGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSL 521
SASQ G PWY E+CSSTLAST+SSG D IAT D + CT SHTGTSA+AP+AAGV AL LEANPNLTWRD+QH++V +S+ +L+ GW +NA G ++ +FG+G+MDA+ M + A W PG + + + L PV SG +I+YLEH+Q ++ Y RG+L IVL SP G S+L
Sbjct: 245 SASQRGNFPWYGEQCSSTLASTFSSGAYT-DQKIATTDTN------DTCTVSHTGTSAAAPLAAGVIALTLEANPNLTWRDVQHLIVYSSSTNGILKNKGWELNAAGYAFNSRFGFGVMDAATMTKNAMKWKNVSPGLSKTYLGQPGNRDLAPGFPVEILFNIGYERPQRVRSG-DDQIKYLEHIQVVTTIKYAVRGSLEIVLRSPQGKDSTL 449 HSP 2 Score: 105.531 bits (262), Expect = 6.895e-24 Identity = 73/219 (33.33%), Postives = 109/219 (49.77%), Query Frame = 0
Query: 13 ESGHGKIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDL--SDSMYISDPLFKDQWFL----NHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGN---DEDPMPQDNSD-----NKHGTRCAGEVAAEAFNGICGVGIAYNASIGG 217
+ HG + N + + I + A+ +A N G++N GP+ + LF + ++ S++ I + + W E ERR DL + +D L+ QW++ + + +NV P + G TG V V +LDDG++ H DL NYDP S D N D DP P S+ N HGTRC+GE++ A N CGVG+AYN+ IGG
Sbjct: 34 DDNHG--FSNEWIVQINGYPSDADTLAFNQGYENIGPVTYAAQ--LFHKKRVKRGFMQSSVKKRGINMDILRI-WDE---ERRSKLEDLPLQATFIFNDELWDHQWYMQDTRSRSSLPAIHLNVLPVYEMGITGNEVRVVVLDDGLEWRHSDLIDNYDPSISYDFNNGTLGDNDPTPHYPSNSYASPNSHGTRCSGEISMVANNDKCGVGVAYNSKIGG 244
BLAST of endoprotease furin vs. L. salmonis genes
Match: EMLSAG00000009763 (supercontig:LSalAtl2s:LSalAtl2s631:444502:450665:-1 gene:EMLSAG00000009763 transcript:EMLSAT00000009763 description:"maker-LSalAtl2s631-snap-gene-3.5") HSP 1 Score: 115.546 bits (288), Expect = 4.604e-29 Identity = 69/196 (35.20%), Postives = 102/196 (52.04%), Query Frame = 0
Query: 415 VNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR--QSQLVSEFGPLPSEDFGD 608
+NA+GR SH +GYGLMD SA+V+VAK W Q C+ ++ IP + +K+ AC +I++LEH SP GT+S+LL RP+D ++ GF +WPF++VH WGE +GTW LE+ H+ + + AK KW + YGT P + + + V+ +P DF D
Sbjct: 1 MNAMGRLVSHSYGYGLMDTSALVKVAKKWNSVPEQMKCKVESPYYYKVIPAMGYITIHLEVKSSAC-----QIKHLEH--------------------SPMGTRSTLLDARPQDYSSNGFTNWPFMTVHSWGEDPSGTWILEI-HNDAYSKLTMHAKFF--KWSLELYGTANDPNQSDEDKDVNVIREVPDTDFLD 168
BLAST of endoprotease furin vs. SwissProt
Match: gi|25453439|sp|P30432.2|FUR2_DROME (RecName: Full=Furin-like protease 2; Short=Furin-2; Flags: Precursor) HSP 1 Score: 970.304 bits (2507), Expect = 0.000e+0 Identity = 546/1231 (44.35%), Postives = 688/1231 (55.89%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLV---------------------------SEFGPLPSEDFGDGLPGKMMDGS----PE------DGHNVSPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR---SCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVS--SCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC 1156
IY N FA++IP G+ A+ IA GF NRG IG+L N++LF+H + R S +H L E V W +QQHE+ R KRD +S DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYDP AS DINGND DP PQDN DNKHGTRCAGEVAA AFN CGVG+AYNASIGGVRMLDG VND VEA+ALSLNP+HIDIYSASWGPEDDG TVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+Q G KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D LRPD ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV TS PAPL +E+GW +N V RKYSHKFGYGLMDA AMV +A+ W Q IC++ + D I GS + + C+GT E+RYLEHVQC+I+L + PRG L I+LTSP GT S+LL RPRD+ F+DWPFLSVHFWGE A G WTL+V + + GI+ KW+++FYGT P+R +S+L+ +E G ++ F L + + S PE DG NV+ G + S G ++ A E G +L SC +C+ + C G T+C +C +++ N CV CP ++ + G C CH +C+TC+G P+ CLTC+ + + D + C++ CP GY + CVPC +C SC + E C C LV + E+KC + CP + E C CH +CATC G C C + +++KC+ CP G+ D EC+PC +GC TC+++ C +C W+ N+++ C + C E F ++ C PCH SC +C G T C+ C + +CV C G+ + C PC C C + C C G N + C +G +S G+CA C +C+TC + + C+ CP L C ECP G FY + C+ C H C TC +C+ C L G G C Y T + C C+ SC +C GP C C
Sbjct: 238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQDNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQ---PGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGFTASAAQLVAAPETRDGDKKILH------SCDAECDSSGCYGRGPTQCVACSHYRLDNTCVSRCPPRSFPNQVGICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQ-FCPDGYFENSRNRTCVPCEPNCASCQDHPE---------------------YCTSCDHHLV--MHEHKCYSACPLD-TYETEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCPDGFYADKKRLECMPCQEGCKTCTSNGVCSECLQNWTL-NKRDKCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEA-GSLCSPCLHTCSQCVSRTNCSNCSKGLELQNG------ECRTTCADGYYSDR--GICAKCYLSCHTCSGPRRNQCVQCPAGWQLAAGEC-HPECPEG-FYKSDFG-CQKCHHYCKTCNDAGPLACTSCPPHSMLDG-GLCMECLSSQYYDTTSATCKTCHDSCRSCFGPGQFSCKGC 1420 HSP 2 Score: 239.965 bits (611), Expect = 1.024e-62 Identity = 178/601 (29.62%), Postives = 268/601 (44.59%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR--SCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC------ESSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFGLGDEALTNPSRSLFHYG--------------SLLAILALMTLVIVKYFKRAKIRLYAMNGSRARRHHQRRRQTSQDLSGTNYQKLLKDEQPADGPLNFN 1391
L+N C++ CP S + C PCH++C TC G C C + C+ CP GY + ++ CVPC C +C + + C C K + CP +++T C CH +CATC G C C + +++KC+ CP G+ D EC+PC +GC TC+++ C +C W+ N+++ C + C E F + G C PC ++C +C AD +C SCP N +L+ S C+ C G F + + C C H C C S ++CS C L +G+C C + Y + G+C C SC C GP N+C+ C G L+ GEC EC GF + CQ CH C C C++CP + L C+ C +++D S C CH+SC +C GP C C PL LD N+ CV CC E + CC+C +C S ++R+ V G ++ + S + G ++ AI + L+I+ F + N + R+ R R+ + SG +K L + +D FN
Sbjct: 992 LDNTCVSRCP-PRSFPNQVGICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCEPNCASCQDHPEYCTSCDHHLVMHEHK------CYSACPLDTYETEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCPDGFYADKKRLECMPCQEGCKTCTSNGVCSECLQNWTL-NKRDKCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSG-CREGFFVEAG-SLCSPCLHTCSQCVSRTNCSNCSKGLELQ-NGECRTTC-ADGYYSDRGICAKCYLSCHTCSGPRRNQCVQCPAGWQLAA-GECHPECPEGFYKSDFGCQKCHHYCKTCNDAGPLACTSCPPHSMLD-GGLCMECLSSQYYDTTSATCKTCHDSCRSCFGPGQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGETGECKATSTG--GKRRTVVGSGSAYKSSESKHGSFENDGNAREFVLRLDSPLTAITAIAVAICLLIITIFS-IIFAVLQRNSNHVSRNSVRYRKIANTSSGR--RKNLSAKPTSDARFIFN 1573
BLAST of endoprotease furin vs. SwissProt
Match: gi|12643811|sp|Q9NJ15.1|PCSK5_BRACL (RecName: Full=Proprotein convertase subtilisin/kexin type 5; AltName: Full=Proprotein convertase PC6-like; Short=aPC6; Flags: Precursor) HSP 1 Score: 743.806 bits (1919), Expect = 0.000e+0 Identity = 521/1366 (38.14%), Postives = 676/1366 (49.49%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDLSD--SMY---------------------ISDPLFKDQ-----WFLN----HGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMP--QDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLR------------ESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVN---HSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDG--------HNVSPNNNGQH----VSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSS-SCHPQCEGNRCSGPKSTECYSCQNFK-FGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCT--------------ETSEGVVNLIEGPRSGSLGIGE-----TTLVCLKCQKGLVRSVLE---------NKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCL-----DGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSN--DQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCV--PDCPAGYRPDVHHQECVPCPQGCHTCS--NDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSS-----------------CLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKC--SANCQGNEYQ-----TPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHG-FVD-KNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLS-CEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSC 1253
+IY N +ALH+ G A A+R+A GF N+G IG+L +H+LF H R S H +L +EP V W +QQ +RR KR + SMY + DP F D+ W+L+ A SDMNV+ AW KGYTGK VVV+ILDDG +TDHPDL NYDP AS+DING DP P + ++N+HGTRCAGEVAA N C VG+AY ASIGGVRMLDG V D+VEA +L LNP HI IYSASWGP+DDGKTVDGP LA+K F G + GRD GSIFVWASGNGGR D+C CDGYTNSI+T+S+SSAS+ GK PWYLE C+STLA+TYSSG P H+ + T D LR K CT SHTGTSASAP+AAG+ ALALEANP LTWRDMQ+IVV+ +NP+PL R ES + N G + SH FG+GLMDA MVE+A+ W Q +CE D + I G T T C+GT ++YLEHV +ISL + RG L I +TSPSGT+S+LL R D ++ G +DW F++ H WGE G W LEV + +++KWK++ YGT + PL + S P + DG D H+ +G+H +S G++ G GQ D E C C + S T C K F N CV C Y+ CQ C SC TC+GP+ C+TC+ L +S+C++ C SGY Q+ EC+ C C SC+ E E I G G E ++C KC LE C+ C G PE C PCH SC C G QC+ C+ + F ++ C CP G D Q C C GC C D +C C E+E Q EGS + C E C +C C C + + E CV +CP+ PD +EC PC C C N+Q C C+ G F + CS CP + C PC S+C TC A +CLSC L SS C++ C +Y ++ C CP+NC C++ C++C + + G+C C+ EYQ T C C++SC+ C GP +C SC+ + GEC+ C G ++D + +C+ACH +C C+ C+ C G L ++C + C P +F H +C +CH C TC GP ++CLSC
Sbjct: 29 RIYRNEWALHVEGGTAAADRLASKHGFINKGQIGSLEDHYLFVHRRTWKRSLRSSSHRHALLQREPEVRWLQQQVVKRRVKRRVKRVYSMYPWEQRVQHSSPQVNNPAQQDNLWDPHFNDEKWDKMWYLHCDRPEFACQWSDMNVEAAWKKGYTGKGVVVSILDDGSETDHPDLAGNYDPDASSDINGGTLDPTPRYEYTNENRHGTRCAGEVAAMGNNSFCSVGVAYKASIGGVRMLDGDVTDSVEAASLGLNPQHIMIYSASWGPDDDGKTVDGPANLAQKTFQAGAENGRDKLGSIFVWASGNGGRTHDSCGCDGYTNSIYTISVSSASEQGKVPWYLEPCASTLATTYSSGAP-HERKVITTD----LR--KGCTESHTGTSASAPMAAGILALALEANPMLTWRDMQYIVVMAANPSPLDRDTESAYPRDPRKESDFVTNGAGLRVSHNFGFGLMDAGKMVELAESWRRVPEQHVCEEDPNAQQRAI--TKGETIVDTKTTGGCNGTDHHVKYLEHVVVEISLDHPCRGHLSIHITSPSGTRSTLLPERQFDSSSDGLKDWAFMTTHCWGEQPEGDWILEVKDLGQQNCQRYGLRTVLPVLRKWKLILYGTAEHPLYKRDEESR-PHTPQTREEPTDEEECEDGDYYDRSKQRCRHCHDSCATCHGRHSGQCLSCHEGNYFVEDE--GTCSEECGQGYYKDEEERKCLDCSADCLTCQVSADHCTSCDDEDGLKLFENTCVAQCSEGRYMDENDVCQDCDDSCDTCTGPDATDCVTCADEDLL--QESQCVE-SCSSGYFQQEY--ECLKCHATCASCSGSRDDQCLTCSGHLELDEDTHRCITSCEDGEYGTEEGKCEDCNIICKKCNGSQADQCLECHHDTNLYDTTCVQYC--GNRRYPENGECHPCHPSCLGCIGGEINQCNQCITDYEGEDHFLYQGTCHVTCPPGLYGDTTDQVCKACAPGCIACDGPADNQCTLC--------EEERAPTDGRCQ-SEGSQTDEA--ECAEGCHSCEEGPDI-CDSCDEDYYLTEDTCVRRTNCPSFTYPDDQDRECRPCHDNCEACDGPNNQNCNSCKEG--FYKTPDGCS----TGCPNRYYKDDTNKECKPCDSSCFTCSGPASFHCLSCADGDFLHESSCRSTCPAGFIGNAESHECVESSCEQDQYYSSETGRCEDCPYNCRACDNDGDCAECAPTYIVV-DGRCRPEETCEDGEYQDRDRDTAELSCRPCHQSCKTCSGPSDTDCDSCKGDDTILDRGECITSCGPGEYMDRREKKCKACHPTCKECSDEYDDTCTACNDGFLLTDASSCEAGCPPGQF--LHHGDCDSCHRECKTCDGPHHDNCLSC 1354 HSP 2 Score: 239.58 bits (610), Expect = 1.615e-62 Identity = 215/756 (28.44%), Postives = 295/756 (39.02%), Query Frame = 0
Query: 670 CHPQCEGNRCSGPKSTECYSC-------QNFKFGNVCVEHCPLTTY-VSLRGTCQACHSSCQTCSGPNPNQCLTCSKSL---------------------------------------FLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVP------------------CPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR-------SCDPCHESCATCTGNLSTQCSLCL-DGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSN--DQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLN-------ECRHCPHNCMTC--ESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVD---KNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCE--SSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFGLGDEALTNPSRSLFHYGSLLAILALMTLV 1335
CHP C G C G + +C C +F + C CP Y + C+AC C C GP NQC C + + L++ + + CPS EC PC +CE+C +GP + + C C++G ++ + C GCP + + + C PC SC TC+G S C C DG F E C CPAG+ + ECV CP C C ND C +C + + + C P+ C +G ++ R SC PCH+SC TC+G T C C D T +C+ C G D ++C C C CS+ D C C G+ + + A CP G F G C C C TC DNCLSC L+ C H CP GTF +T + +CR C NC TC E C +C D G+C CQ Y C C CE C GP +++C++C YL G+CLE+C G+ D + +C CH SC C + C +CP G+KLG CE +++ + C C SC TC G + CLSC P C CCE S + ++CC C S C+ R+ V+F D TN +A +A+ T +
Sbjct: 924 CHPSCLG--CIGGEINQCNQCITDYEGEDHFLYQGTCHVTCPPGLYGDTTDQVCKACAPGCIACDGPADNQCTLCEEERAPTDGRCQSEGSQTDEAECAEGCHSCEEGPDICDSCDEDYYLTEDTCVRRTNCPSFTYPDDQDRECRPCHDNCEAC-----------DGPNNQN---------CNSCKEGFYKT--PDGCSTGCPNRYYKDDTNKECKPCDSSCFTCSGPASFHCLSCADGDFLHESSCRSTCPAGFIGNAESHECVESSCEQDQYYSSETGRCEDCPYNCRACDNDGDCAECAPTYIVVDGR--CRPEET--CEDGEYQDRDRDTAELSCRPCHQSCKTCSGPSDTDCDSCKGDDTILDRGECITSCGPGEYMDRREKKCKACHPTCKECSDEYDDTCTACNDGFLLTD-----ASSCEAGCPPGQFLHH--GDCDSCHRECKTCDGPHHDNCLSCQPGSYLNDQQCSTH-CPEGTFEETYEDDSGETVLQCRLCHVNCKTCHGEGEEDCMECANDIKYKQDGRCVTECQEGHYPDLTNECQQCWSDCETCDGPRNDQCVTCPYNYYL-VLGKCLEDCPEGYYDTMRQEKECGECHPSCATCNEGGNYNCLSCPYGSKLGEGVCYPMCEEHEYYVEKTQICEECDNSCKTCRGSTAHDCLSCEAPYGYHAMKHLCTACCEEGSPENEYCCICHESTRLCI------TDREAEGVQFSSADSIPTN-----------VAYIAVATFI 1625 HSP 3 Score: 151.754 bits (382), Expect = 1.802e-35 Identity = 145/487 (29.77%), Postives = 200/487 (41.07%), Query Frame = 0
Query: 828 GFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHK--CVPDCPAGYRPDVHHQECVPCPQGCHTCS-NDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS--CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCS--NDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCF-DKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTC--ESVSSCSQC-----GLDHFLTGSGKCSANCQGNEY-QTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEE--------CLHG---------------------------------FV---DKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCS 1254
G + + C CH+SCATC G S QC C +G ++ E + C +C GY D ++C+ C C TC + C C + C AQC EG + + C C +SC TCTG +T C C D E +CV C +GY + EC+ C C +CS D +C+ C + C C +G + G C C C C +AD CL C + L ++C+ + C N + + EC C +C+ C ++ C+QC G DHFL G C C Y T + +C AC C AC GP N+C C + T G C E C G F D++ +C+ CH +C AC GP+ C++C G P C R + D + EC C SC TCSGP HCLSC+
Sbjct: 667 GDYYDRSKQRCRHCHDSCATCHGRHSGQCLSCHEGNYFVEDEGTCSEECGQGYYKDEEERKCLDCSADCLTCQVSADHCTSCDDEDGLKLFENTCV----AQCSEGRYMDENDVCQDCDDSCDTCTGPDATDCVTCADEDLLQESQCVESCSSGYFQQEY--ECLKCHATCASCSGSRDDQCLTCSGHLELDEDTHRCI----TSCEDGEYGTEEGK-CEDCNIICKKCNGSQADQCLECHHDTNLYDTTCVQY-CGNRRY--PENGECHPCHPSCLGCIGGEINQCNQCITDYEGEDHFLY-QGTCHVTCPPGLYGDTTDQVCKACAPGCIACDGPADNQCTLCEEER-APTDGRCQSEGSQTDEAECAEGCHSCEEGPDICDSCDEDYYLTEDTCVRRTNCPSFTYPDDQDRECRPCHDNCEACDGPNNQNCNSCKEGFYKTPDGCSTGCPNRYYKDDTNKECKPCDSSCFTCSGPASFHCLSCA 1137 HSP 4 Score: 97.4413 bits (241), Expect = 6.333e-19 Identity = 75/252 (29.76%), Postives = 119/252 (47.22%), Query Frame = 0
Query: 1028 EGSFSKALGGLCAPCGSTCNTCFDK-ADNCLSCPK-NHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCE-SVSSCSQC----GLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQAN-CL-SCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC 1270
+G + C C +C TC + + CLSC + N+ ++ EC G + D + +C C +C+TC+ S C+ C GL F C A C Y N +C C+ SC+ C GP + +C++C L + +C+E C G+ + +C CH++C +C+G QC TC +L + C+ SCE ++ +C C+ C C+G Q + CL C L ++TTCV C
Sbjct: 666 DGDYYDRSKQRCRHCHDSCATCHGRHSGQCLSCHEGNYFVEDEGTCSEECGQGYYKDEEERKCLDCSADCLTCQVSADHCTSCDDEDGLKLF---ENTCVAQCSEGRYMDENDVCQDCDDSCDTCTGPDATDCVTCADEDLLQES-QCVESCSSGYFQQEYECLKCHATCASCSGSRDDQCLTCSGHLELDEDTHRCITSCEDGEY-GTEEGKCEDCNIICKKCNGSQADQCLECHHDTNL--YDTTCVQYC 910 HSP 5 Score: 92.8189 bits (229), Expect = 1.665e-17 Identity = 70/204 (34.31%), Postives = 92/204 (45.10%), Query Frame = 0
Query: 1077 NGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGL-DHFLTGSGKCSANC-QGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLST-TGECLEECLHG-FVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCESSD 1274
+G +YD CRHC +C TC S C C ++F+ G CS C QG CL C+ C C ++ C SC L C+ +C G ++D+N CQ C SC CTGP C TC L SC F + ECL CH +C +CSG +D+ CL+CS L LD C+ CE +
Sbjct: 666 DGDYYDRSKQRCRHCHDSCATCHGRHSGQCLSCHEGNYFVEDEGTCSEECGQGYYKDEEERKCLDCSADCLTCQ-VSADHCTSCDDEDGLKLFENTCVAQCSEGRYMDENDVCQDCDDSCDTCTGPDATDCVTCADEDLLQESQCVESCSSGYFQQEY--ECLKCHATCASCSGSRDDQCLTCSGHLELDEDTHRCITSCEDGE 866
BLAST of endoprotease furin vs. SwissProt
Match: gi|357529585|sp|Q92824.4|PCSK5_HUMAN (RecName: Full=Proprotein convertase subtilisin/kexin type 5; AltName: Full=Proprotein convertase 5; Short=PC5; AltName: Full=Proprotein convertase 6; Short=PC6; Short=hPC6; AltName: Full=Subtilisin/kexin-like protease PC5; Flags: Precursor) HSP 1 Score: 733.791 bits (1893), Expect = 0.000e+0 Identity = 495/1324 (37.39%), Postives = 654/1324 (49.40%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDL----SDSMYISDPLFKDQWFLNHGAFD---GSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNS--DNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGT-KKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFG-----NVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVH----HQECVPCPQGCHTCSND--QKCIKCQAGW----------------SFANEKEACSP----------------------------QANAQCPEGSFKTRS-CDPCHESCATCTGNLSTQCSLCLDGTFYFEH-----KCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTC-FDKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEY-QTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECL-----EECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSL----PLVL 1259
++Y NH+A+ I G +ANRIA GF N G IG L +++ F H R S H + EP V W +QQ ++R KRD + S Y +DP + W+++ SDMN++ AW +GYTGK +VVTILDDGI+ HPDL +NYD LAS D+NGND DPMP+ ++ +NKHGTRCAGEVAA A N C VGIA+NA IGGVRMLDG V D VEA+++S NP H+ IYSASWGP+DDGKTVDGP PL ++AF NGV+ GR G GS+FVWASGNGGR D+C+CDGYTNSI+T+SISS ++ GKKPWYLEECSSTLA+TYSSG +D I T D R CT +HTGTSASAP+AAG+ ALALEANP LTWRD+QH++V TS A L + W+ NA G K SH +G+GLMDA AMV A+ W RQ +C T I N S R K CS + + YLEHV +I++ + RG L I LTSPSGT+S LL R D + GF++W F+++H WGE A G W LEV +PS + + G +K+W ++ YGT P SP N V S +E G DY P C P+C C GP C C ++ + +CV CP Y + + C+ C +C++C G + +QC++C FL + + C+ CP G Q N C C +C++CTE C +C+ GL S+ ++C C G N + C PCH CATC G + C C +G F + +CV C Y D ++ C C C TC+ + C C +G+ + +E C + + CP F+ + C PCH +C C G+ T C+ C + EH +C CP G+ C+PCP C C + C +C G+ A C +C +G C PC C C D C SC + C CP T+ ++ EC+ C NC +C+ + C C FL G G C C Y G C +C+R+CE C GP +EC SC+ G L G C+ +E + D + Q CHSSC C G + C++CP G L QA SC + S C C E+C CSG + C C + PL L
Sbjct: 33 RVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGE-SYDKKIITTDLRQR------CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR-AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPN--SAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPS-QLRNFKTPGKLKEWSLVLYGTSVQPY------------------------------------SPTNEFPKVERFRYS---------RVEDPTDDYGTEDYAGP---CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCTEFHN----------------------CTECRDGL--SLQGSRCSVSCEDGRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGADNYGREHFLYQGECGDSCPEGHYA-TEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTCQ---KLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYRFDHHCYK-TCPEKTY--SEEVECKACDSNCGSCDQ-NGCYWCEEGFFLLG-GSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQL-LRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATL-CTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGA--DLCKKCQMQPGHPLFL 1257 HSP 2 Score: 224.172 bits (570), Expect = 1.147e-57 Identity = 211/712 (29.63%), Postives = 306/712 (42.98%), Query Frame = 0
Query: 687 CYSCQN--FKFGNVCVEHCPLTTYVSLR-GTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESC-------TETSEGVVNLIEG------------PRSGSL-------GIGETTLVCLKCQK--GLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFK-TRSCDPCHESCATCTGNLSTQCSLCLDGTFY-FEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKA-DNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEY-QTPNGLCLACNRSCEACMGPHSNECLSC-RVGKYLSTTGECLEECL-HGFVDKNSQ-CQACHSSCLACTGPSLFQCSTCPSGTKLGP---QANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCESSD---EKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFGLGDEALTNPSRSLFHYGSLLAILALMTLVIVKYFKRAKIRLYAMNG 1352
CY C+ F G CV C Y G C++CH +C+TC+GP ++C +C + L LL G L + PC C++C T +G L + RSGS I +C KCQ G + E +C + CP G E C+ C C TC GN +T C C G C +CP R C CP+ C C +++ C +C + ++ + CP G + +R C PCH+ C C+G + C LCL+ ++ ++ C+ +CPAG + +EC C + C TCS+ C CQ G N + +C AN +C + C PC C C A D C +CP N +L ++C+ +CP G + D N C HC +C TCE S C C F G +C C+ Y G C CNRSC+ C GP +CLSC R L + GEC C H +V++++Q C+ CH +C C G C +C L ++CL E R + C CHESC C GP +C C LVL ++ C+ CC +SD + CC C + D+C+ + K+ A + +LF S++ +L L V+V R +++ A G
Sbjct: 1097 CYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY--AEDGICERCSSPCRTCEGN-ATNCHSCEGGHVLHHGVCQENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDD------MCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGL-IMNPRGSC--MANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVK-DCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGK-ECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYR-VGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECILRTSKVRP-------------ATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG 1778 HSP 3 Score: 194.126 bits (492), Expect = 1.767e-48 Identity = 189/662 (28.55%), Postives = 255/662 (38.52%), Query Frame = 0
Query: 661 LDYESPSSSCHPQCEGNRCSGPKSTECYSC-------QNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSN--DQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKT---RSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWS---FANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHG--FVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLS-------------------CEPRKFH---------------------------------DAHSDECLACHESCGTCSGPQDNHCLSC 1253
++E+ CH C+ RC G T C SC ++F + C + CP Y + TC C +C+ C + + C C K F+ C K +C G Q P ECVPC C C+ G C C G R ++ C CP E C C +C +C N C C +G F CV C G+ D EC C + C TC+ +C CQ G + C Q EG F R PCH SC TC G+ +T C+ C G + CV CP G P V C C + C CS C KCQ F +E + ++CPEGS+ A G+C C S C TC A NC SC HVL C ++ CP + C+HCP C C +C +C + FL C +C Y C+ C++ C C GP +++C C ++ G CLEEC G + + +C+ CH SCL C+ S C+TC G + P+ +C++ C + FH D S+ C CH SC TC G C SC
Sbjct: 926 FEFENQCHPCHHTCQ--RCQGSGPTHCTSCGADNYGREHFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCH--SVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGT--------------------CTSCAMGYYR--FDHHCYKTCPE--KTYSEEVECKACDSNCGSCDQN---GCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLL--RGMCVHATKTQ-EEGKFWNDILRKLQPCHSSCKTCNGS-ATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEG-----RCYSKCPEGSY--AEDGICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQEN-CPERHVAVKGV--CKHCPEMCQDCIHEKTCKECTPEFFLHDD-MCHQSCPRGFYADSRH-CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCS--SSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSC 1538 HSP 4 Score: 95.5153 bits (236), Expect = 2.738e-18 Identity = 93/321 (28.97%), Postives = 128/321 (39.88%), Query Frame = 0
Query: 670 CHPQCEGNRCSGPKSTECYSCQN---FKFGNVCVEHCPLTTYVSLRGT-CQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQC-PSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENK-CLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQ--KCIKCQAGWSFANEKEACSPQANAQCPEGSF---KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAG-YR 978
CH C CSGPK+ +C C + +C+E CP TY C+ CH SC TCS + C TC K L + S ++C PS Y + C PC C C +E +CQ + S+L N C+ CP G+ + ++ C CH SC TC G S QC C G F +C+ C GY D C C + C C + C+ C + K C + CP+ + T++C+ CH +C C G + C C+ C DC G YR
Sbjct: 1371 CHKDCL--ECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCS--SSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPG-CKPCHVKCFHCMGPAED-----------------------QCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC----HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYR 1659 HSP 5 Score: 70.8626 bits (172), Expect = 7.582e-11 Identity = 61/193 (31.61%), Postives = 83/193 (43.01%), Query Frame = 0
Query: 670 CHPQCEGNRCSGPKSTECYSCQN--FKFGNVCVEHCPLTTYV-SLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLC 859
CH C C G S +C+SC+ F+ G C+ C Y + G C+ C+ SC+ C GP P CL+C + FLL + C + CP Y S C C C+ C +G +N + S L G T CL V E + G E +C+ CHESC C G + C+LC
Sbjct: 1520 CHSSCR--TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHR-SCPDHYYVEQSTQTCERCHPTCDQC--KGKGALNCLSCVWSYHLMGGICTSDCL---------VGEYRVGEG---------EKFNCEKCHESCMECKGPGAKNCTLC 1689 HSP 6 Score: 65.0846 bits (157), Expect = 4.644e-9 Identity = 73/233 (31.33%), Postives = 91/233 (39.06%), Query Frame = 0
Query: 1075 CPNGTFYDTQLNECRHCPHNCMTC--ESVSSCSQCGLDHFLTG-SGKCSANCQGNEYQ-TPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDE-----CLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC---ESSDEK-HCCSCTPSRDKCLQPSKK 1294
CP G Y CR C NC +C C C +FL + C +C YQ T LC C+ +C+ C H+ C CR G L + C C G CQ CH C C G C C G + SC + D HS E C C SC TC+GP +C SC +LD C E DE HC +C S KC P+++
Sbjct: 674 CPPG-HYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHN--CTECRDGLSLQGS-RCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD-HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQGPTQE 901
BLAST of endoprotease furin vs. SwissProt
Match: gi|341942205|sp|Q04592.3|PCSK5_MOUSE (RecName: Full=Proprotein convertase subtilisin/kexin type 5; AltName: Full=Proprotein convertase 5; Short=PC5; AltName: Full=Proprotein convertase 6; Short=PC6; AltName: Full=Subtilisin-like proprotein convertase 6; Short=SPC6; AltName: Full=Subtilisin/kexin-like protease PC5; Flags: Precursor) HSP 1 Score: 723.391 bits (1866), Expect = 0.000e+0 Identity = 499/1332 (37.46%), Postives = 651/1332 (48.87%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDL----SDSMYISDPLFKDQWFLNHGAFD---GSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNS--DNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGT-KKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFG-----NVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVH----HQECVPCPQGCHTCSND--QKCIKCQAGW----------SFANEKEACSPQANAQ----------------------------------CPEGSFK-TRSCDPCHESCATCTGNLSTQCSLCL-----DGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCF-DKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANC-QGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEEC--------------------------------LHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSG 1244
++Y NH+A+ I G A+A+RIA GF N G IG L +++ F H R S H + EP V W +QQ ++R KRD + S Y +DP + W+++ SDMN++ AW +GYTGK +VVTILDDGI+ HPDL +NYD LAS D+NGND DPMP+ ++ +NKHGTRCAGEVAA A N C VGIA+NA IGGVRMLDG V D VEA+++S NP H+ IYSASWGP+DDGKTVDGP PL ++AF NGV+ GR G GS+FVWASGNGGR D+C+CDGYTNSI+T+SISS ++ GKKPWYLEECSSTLA+TYSSG +D I T D R CT +HTGTSASAP+AAG+ ALALEANP LTWRD+QH++V TS A L + W+ NA G K SH +G+GLMDA AMV A+ W +Q +C T I N S R K CS + YLEHV +I++ + RG L I LTSPSGT+S LL R D + GF++W F+++H WGE A G W LEV +PS + + G +K+W ++ YGT P SP N V S +E G DY P C P+C C GP C C ++ + +CV CP Y + + C+ C +C++C G + NQCL+C FL + S C+ QCP G + N C C +C++C G N C +C+ GL S+ ++C C G N C PCH CATC+G + C C +G E +CV C Y D ++ C C C TC+ + C C +G+ + + E Q + Q CP F+ + C PCH +C C G+ + C+ C F + +C+ +CP G+ P H C+PCP C C N C +C +G+ C +C +G F + C PC C C D C SC + + C CP TF ECR C NC +C+ C C FL+G G C +C G G C C+R+CE C G N+C SC+ G L G CL + D SQ Q CHSSC C G SL C++CP+G L QA SC + S C C E C +CSG
Sbjct: 35 RVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSHAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGE-SYDKKIITTDLRQR------CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR-AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPN--SAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPS-QLRNFKTPGKLKEWSLVLYGTSVQPY------------------------------------SPTNEFPKVERFRYS---------RVEDPTDDYGAEDYAGP---CDPECSEVGCDGPGPDHCSDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVT-QCPDGSYEDIKKNVCGKCSENCKACI----GFHN------------------CTECKGGL--SLQGSRCSVTCEDGQFFN--GHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSSEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQMGAICKDGEYIDDQGHCQTCEASCAKCWGPTQEDCISCPVTRVLDDGRCVMNCPSWKFEFKKQCHPCHYTCQGCQGSGPSNCTSCRADKHGQERFLYHGECLENCPVGHYPAKGHA-CLPCPDNCELCYNPHVCSRCMSGYVIIPPNHTCQ---KLECRQGEFQDSEYEECMPCEEGCLGCTEDDPGACTSCATGYYMFERHCYK-ACPEKTFGVKW--ECRACGTNCGSCDQ-HECYWCEEGFFLSG-GSCVQDCGPGFHGDQELGECKPCHRACENCTGSGYNQCSSCQEGLQL-WHGTCLWSTWPQVEGKDWNEAVPTEKPSLVRSLLQDRRKWKVQIKRDATSQNQPCHSSCKTCNG-SL--CASCPTGMYLWLQACVPSCPQGTWPSVTSGSCEKCSEDCVSCSG 1267 HSP 2 Score: 190.66 bits (483), Expect = 2.267e-47 Identity = 185/698 (26.50%), Postives = 288/698 (41.26%), Query Frame = 0
Query: 676 GNRCSGPKSTECYSCQN--FKFGNVCVEHC-PLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTL----------------VCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTG-NLSTQCSLCLDGTFYF-EHKCVPDCPAGYR-----------------------------------------PDVH---HQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSF-KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHK-CVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKA-DNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEY-QTPNGLCLACNRSCEACMGPHSNECLSCRVGKYL-STTGECLEEC-LHGFVDKNSQ-CQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDE--CLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCESSDEKH---CCSCTPSRDKCLQPSKK 1294
G C ECY C+ F G CV+ C P G C+ CH +C+ C+G NQC +C + L L C+ P + NE VP TE V +L++ R + I +C C G+ + C+ CP G + + SC+ C E C +C+G +L QC D T E +C CP G+ P+ H C CP+ C C +++ C +C + N+ + CP+ + R C PCH++C C G C +C D + + C+ +CP G + + EC CP+ C CS+ C+ C+ G++ ++ C+ A +C + C PC C+ C + D C +CP+ L ++C+ ECP G D +C C +C TCE S C C F G +C C+ Y ++ +G C C++SC++C GP +C SC +L + G+C C H + D+++Q C+ CH +C C+G + C +C L C ++ + + C CHESC C GP +C CS L+LD + C+ CC +S + CC C S D+C+ P+++
Sbjct: 1088 GTNCGSCDQHECYWCEEGFFLSGGSCVQDCGPGFHGDQELGECKPCHRACENCTGSGYNQCSSCQEGLQLW--HGTCLWSTWPQ--VEGKDWNEAVP--------TEKPSLVRSLLQDRRKWKVQIKRDATSQNQPCHSSCKTCNGSLCASCPTGMY--LWLQACVPSCPQGTWPSVTSGSCEKCSEDCVSCSGADLCQQCLSQPDNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCEGNATSCNSCEGDFVLDHGVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYND------MCHRSCPKSFYPDMRQCVPCHKNCLECNGPKEDDCKVCADTSKALHNGLCLDECPEGTYKEEENDECRDCPESCLICSSAWTCLACREGFTVVHD--VCT--APKECAAVEYWDEGSHRCQPCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVK-ECPEGYHTDKDSQQCVLCHSSCRTCEGPHSMQCLSCRPGWFQLGK-ECLLQCRDGYYGESTSGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLRSKGQCHRACPEHYYADQHAQTCERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEYREGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLDMDDNRCLHCCNASHSRRSQDCCDCQSSTDECILPARE 1759 HSP 3 Score: 163.31 bits (412), Expect = 4.817e-39 Identity = 166/575 (28.87%), Postives = 234/575 (40.70%), Query Frame = 0
Query: 662 DYESPSSSCHPQCEGNRCSGPKSTECYSCQN--FKFGNVCVEHCPLTTYVSL-RGTCQACHSSCQTCSGPNP-NQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEG---VVNLIEGPRSGSLGIGETTL---------VCLKCQKGLVRSVLENKCLNGCPFGF------------SLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHK-CVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCS--NDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHE-CPNGTFYDTQLNECRHCPHNCMTC--ESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGL---CLACNRSCEACMGPHSNECLSCRVGKYLST-TGECLEECLHGFVDKNSQCQACHSSCLACTGPS 1197
D S + CH C+ C+G + C SC + + CV CP T+ S+ G+C+ C C +CSG + QCL+ + LL + RC CP G+ + + E HC S +T EG N EG G+ T VC C + + E C P F S P+ R C PCH++C C G C +C D + + C+ +CP G + + EC CP+ C CS+ C+ C+ G++ ++ +P+ A + C PCH+ C+ C+G QC C TF CV +CP GY D Q+CV C C TC + +C+ C+ GW F KE QC +G + ++ G C C +C +C + +C SC L S H CP + D C C C C + SC C + L G C C EY+ G C C+ SC C GP S C C G L CL C ++ C C SS C P+
Sbjct: 1204 DATSQNQPCHSSCK--TCNG---SLCASCPTGMYLWLQACVPSCPQGTWPSVTSGSCEKCSEDCVSCSGADLCQQCLSQPDNTLLLH-EGRCYH-SCPEGFYAKDGVCE------HCSSPCKTCEGNATSCNSCEGDFVLDHGVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHRSCPKSFYPDMRQCVPCHKNCLECNGPKEDDCKVCADTSKALHNGLCLDECPEGTYKEEENDECRDCPESCLICSSAWTCLACREGFTVVHDV-CTAPKECAAVEYWDEGSHRCQPCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYHTDKDSQQCVLCHSSCRTCEGPHSMQCLSCRPGW-FQLGKECL-----LQCRDGYYGESTSGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLRSKGQCHRACPEHYYADQHAQTCERCHPTCDKCSGKEAWSCLSCVWSYHLL-KGICIPECIVGEYREGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLDMDDNRCLHCCNASHSRRSQDCCDCQSSTDECILPA 1757 HSP 4 Score: 67.0106 bits (162), Expect = 1.082e-9 Identity = 69/233 (29.61%), Postives = 94/233 (40.34%), Query Frame = 0
Query: 1075 CPNGTFYDTQLNECRHCPHNCMTC--ESVSSCSQCGLDHFLTG-SGKCSANCQGNEYQ-TPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDE-----CLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCES----SDEKHCCSCTPSRDKCLQPSKK 1294
CP G Y CR C NC +C + C C +FL + C C Y+ +C C+ +C+AC+G H+ C C+ G L + C C G CQ CH C C+G C C G + SC + D HS E C C SC TC+GP +C SC +LD C+ D+ HC +C S KC P+++
Sbjct: 676 CPPG-HYHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHN--CTECKGGLSLQGS-RCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYYLD-HSSEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQMGAICKDGEYIDDQGHCQTCEASCAKCWGPTQE 903
BLAST of endoprotease furin vs. SwissProt
Match: gi|353526321|sp|P41413.3|PCSK5_RAT (RecName: Full=Proprotein convertase subtilisin/kexin type 5; AltName: Full=Proprotein convertase 5; Short=PC5; AltName: Full=Proprotein convertase 6; Short=PC6; AltName: Full=Subtilisin/kexin-like protease PC5; Short=rPC5; Flags: Precursor) HSP 1 Score: 710.294 bits (1832), Expect = 0.000e+0 Identity = 494/1293 (38.21%), Postives = 643/1293 (49.73%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDL----SDSMYISDPLFKDQWFLNHGAFD---GSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNS--DNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGT-KKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFG-----NVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVH----HQECVPCPQGCHTCSND--QKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS--CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTC-FDKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPN-GLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEEC---LHGFV-----------------------------DKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSC 1253
++Y NH+A+ I G A+A+RIA GF N G IG L +++ F H R S H + EP V W +QQ ++R KRD + S Y +DP + W+++ SDMN++ AW +GYTGK +VVTILDDGI+ HPDL +NYD LAS D+NGND DPMP+ ++ +NKHGTRCAGEVAA A N C VGIA+NA IGGVRMLDG V D VEA+++S NP H+ IYSASWGP+DDGKTVDGP PL ++AF NGV+ GR G GS+FVWASGNGGR D+C+CDGYTNSI+T+SISS ++ GKKPWYLEECSSTLA+TYSSG +D I T D R CT +HTGTSASAP+AAG+ ALALEANP LTWRD+QH++V TS A L + W+ NA G K SH +G+GLMDA AMV A+ W +Q +C T I N S R K CS + YLEHV +I++ + RG L I LTSPSGT+S LL R D + GF++W F+++H WGE A G W LEV +PS + + G +K+W ++ YGT P SP N V S +E G DY P C P+C C GP C C ++ + +CV CP + + + C+ C +C++C G + +QCL+C FL + S C+ QCP G Q N C C +C++CT G N C +C+ GL S+ ++C C G + C PCH CATC G + C C +G E +CV C Y D ++ C C C TC+ + C C +G+ + C Q A C +G + C C SCA C G C C + + +CV +CP+ ++ ++ Q C PC C C + P C G F + G C PC C C D C SC + + C CP TF + EC+ C NC +C+ C C FL+ SG C +C Y G C C+R+CE C G N+C SC G L G C+ + G V D Q Q CHSSC C G SL C++CP+GT L QA SC + S C C E C +CSG D+ C C
Sbjct: 35 RVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGE-SYDKKIITTDLRQR------CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR-AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPN--SAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPS-QLRNFKTPGKLKEWSLVLYGTSVQPY------------------------------------SPTNEFPKVERFRYS---------RVEDPTDDYGAEDYAGP---CDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVA-QCPEGSYQDIKKNICGKCSENCKTCT----GFHN------------------CTECKGGL--SLQGSRCSVTCEDGQFFS--GHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLL--DLGMC--QMGAICKDGEYIDEQGHCQICDASCAKCWGPTQDDCISCPITRVFDDGRCVMNCPS-WKFELKKQ-CHPCHHTCQGC-------------------QGSGPSNCTSCKAGEFQDSEYGECMPCEEGCVGCTVDDPGACTSCATGYYMFERHCYK-ACPEKTFGEKW--ECKACGTNCGSCDQ-HECYWCEEGFFLS-SGSCVQDCDPGFYGDQELGECKPCHRACETCTGLGYNQCSSCPEGLQL-WHGTCIWPTWPHVEGKVWNEAVPTEKPSLVRSLPQDRRKWKVQIKRDATRQYQPCHSSCKTCNG-SL--CTSCPAGTYLWLQACVPSCPQGTWLSVRSSSCEKCAEGCASCSG--DDLCQRC 1205 HSP 2 Score: 188.734 bits (478), Expect = 7.044e-47 Identity = 192/665 (28.87%), Postives = 251/665 (37.74%), Query Frame = 0
Query: 678 RCSGPKSTECYSC---QNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCP---FGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSN--DQKCIKCQAG--------------------WSFANEKEACSPQANAQCPEGSFK---------TRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHG--------------------------------------------------FVDKNS-QCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFH-DAHSDECLACHESCGTCSGPQDNHCLSC 1253
+C GP +C SC + F G CV +CP + L+ C CH +CQ C G P+ C +C F Q EC+PC C CT G C C G + E C CP FG E C C +C +C + +C C +G F CV DC G+ D EC PC + C TC+ +C C G W+ A E P P+ K TR PCH SC TC G+L C+ C GT+ + CVP CP G V C C +GC +CS D C +C + +N + CPEG ++K G+C C S C TC A +C SC + VLD C + CP + C+HCP C C +C +C D FL C +C N Y C+ C+++C C GP ++C +C + G CL+EC G + D S +CQ CH C C+GPS QC TCP T L C+ P +H D S +C+ CH SC TC GP CLSC
Sbjct: 896 KCWGPTQDDCISCPITRVFDDGR-CVMNCPSWKF-ELKKQCHPCHHTCQGCQGSGPSNCTSCKAGEF------------------QDSEYGECMPCEEGCVGCTVDDPGA--------------------CTSCATGYY--MFERHCYKACPEKTFG-----EKWECKACGTNCGSCDQH---ECYWCEEGFFLSSGSCVQDCDPGFYGDQELGECKPCHRACETCTGLGYNQCSSCPEGLQLWHGTCIWPTWPHVEGKVWNEAVPTE--KPSLVRSLPQDRRKWKVQIKRDATRQYQPCHSSCKTCNGSL---CTSCPAGTYLWLQACVPSCPQGTWLSVRSSSCEKCAEGCASCSGDDLCQRCLS--QPSNTLLLHEGRCYHSCPEGFYAK--DGVCEHCSSPCKTCKGNATSCHSCEGDFVLDHGVCWE-TCPEKHVAVEGV--CKHCPERCQDCIHEKTCKECMPDFFLYND-MCHHSCPKNFYPDMR-QCVPCHKNCLGCNGPKEDDCKACADTSKVLHNGLCLDECPKGTYKDEVNDECRDCPESCLICSSAWTCLTCREGFTVVQDVCTAPKECAAIEYWDVGSHRCQPCHRKCSRCSGPSENQCYTCPRETFL-LNTTCVKECPEGYHTDKDSHQCVPCHSSCRTCEGPHSMQCLSC 1495 HSP 3 Score: 188.734 bits (478), Expect = 9.015e-47 Identity = 189/696 (27.16%), Postives = 285/696 (40.95%), Query Frame = 0
Query: 676 GNRCSGPKSTECYSCQN--FKFGNVCVEHCPLTTYVSLR-GTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTL--------VCLKCQKGLVRS------VLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCL----DGTFYFEHKCVPDCPAGYR-----------------------------------------PDVH---HQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSF-KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHK-CVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKADN-CLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEY-QTPNGLCLACNRSCEACMGPHSNECLSCRVGKYL-STTGECLEEC-LHGFVDKNSQ-CQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDE--CLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCESS---DEKHCCSCTPSRDKCLQPS 1292
G C ECY C+ F CV+ C Y G C+ CH +C+TC+G NQC +C + L L CI P + + NE VP TE V +L + R + I C C L S + C+ CP G L+ + SC+ C E CA+C+G+ C CL + E +C CP G+ P+ H C CP+ C C +++ C +C + N+ + CP+ + R C PCH++C C G C C D + + C+ +CP G D + EC CP+ C CS+ C+ C+ G F ++ C+ A +C + C PC C+ C ++N C +CP+ L ++C+ ECP G D ++C C +C TCE S C C F G +C C+ Y ++ +G C C++SC+ C GP +C SC +L + G+C C H + D+++Q C+ CH +C C+G + C +C L C ++ D + C CHESC C GP +C CS L+L ++ C+ CC +S + CC C S D+C+ P+
Sbjct: 1019 GTNCGSCDQHECYWCEEGFFLSSGSCVQDCDPGFYGDQELGECKPCHRACETCTGLGYNQCSSCPEGLQLW--HGTCIWPTWP--HVEGKVWNEAVP--------TEKPSLVRSLPQDRRKWKVQIKRDATRQYQPCHSSCKTCNGSLCTSCPAGTYLWLQACVPSCPQGTWLSVRSSSCEKCAEGCASCSGD--DLCQRCLSQPSNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCKGNATSCHSCEGDFVLDHGVCWETCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYND------MCHHSCPKNFYPDMRQCVPCHKNCLGCNGPKEDDCKACADTSKVLHNGLCLDECPKGTYKDEVNDECRDCPESCLICSSAWTCLTCREG--FTVVQDVCT--APKECAAIEYWDVGSHRCQPCHRKCSRCSGPSENQCYTCPRETFLLNTTCVK-ECPEGYHTDKDSHQCVPCHSSCRTCEGPHSMQCLSCRPGWFQLGK-ECLLQCRDGYYGESTSGRCEKCDKSCKTCRGPQPTDCQSCDTFFFLLRSKGQCHLACPEHYYADQHAQTCERCHPTCDKCSGKEAWNCLSCVWSYHLLKGICTPECIVGEYRDGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLQMDDSRCLRCCNASHPHRSQDCCDCQSSTDECILPA 1688 HSP 4 Score: 127.872 bits (320), Expect = 2.995e-28 Identity = 101/347 (29.11%), Postives = 148/347 (42.65%), Query Frame = 0
Query: 925 AQCPEGSFKT--RSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDK-ADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQL----NECRHCPHNCMTCES--VSSCSQCGLDHFL-TGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVL 1259
+ CP G F + C C +C +C G+ + QC C G F E CV CP G D+ C C + C TC+ C +C+ G S + + C +G F G C PC C TC AD C++C + +V++ C+ C + D L C+ C ++C+TC +CS C + L G + A C+ EY G C C+ SC C GP ++C+SC + + G C+ C + QC CH +C C G GP +NC SC+ +F D+ EC+ C E C C+ C SC+ +
Sbjct: 674 SSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSENCKTCTGFHNCTECKGGLSLQGSR------CSVTCEDGQFFS--GHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCV-QSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGMCQMGAICKDGEYIDEQGHCQICDASCAKCWGPTQDDCISCPITRVFDD-GRCVMNCPSWKFELKKQCHPCHHTCQGCQGS--------------GP-SNCTSCKAGEFQDSEYGECMPCEEGCVGCTVDDPGACTSCATGYYM 995 HSP 5 Score: 70.8626 bits (172), Expect = 7.606e-11 Identity = 44/145 (30.34%), Postives = 71/145 (48.97%), Query Frame = 0
Query: 1119 CSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLS-TTGECLEECLHGFVD--KNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLD 1260
C ++C + C C +CE+C G H+++CLSC+ G +L+ T C+ +C G K + C C +C CTG C+ C G L ++CE +F H +C CH C TC+G + C++C+ V++
Sbjct: 672 CVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSENCKTCTG--FHNCTECKGGLSLQGSRCSVTCEDGQFFSGH--DCQPCHRFCATCAGAGADGCINCTEGYVME 812
BLAST of endoprotease furin vs. SwissProt
Match: gi|129542|sp|P29122.1|PCSK6_HUMAN (RecName: Full=Proprotein convertase subtilisin/kexin type 6; AltName: Full=Paired basic amino acid cleaving enzyme 4; AltName: Full=Subtilisin-like proprotein convertase 4; Short=SPC4; AltName: Full=Subtilisin/kexin-like protease PACE4; Flags: Precursor) HSP 1 Score: 667.537 bits (1721), Expect = 0.000e+0 Identity = 382/920 (41.52%), Postives = 521/920 (56.63%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDLS---DSMYISDPLFKDQWFLNHGAFDG---SDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNS--DNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSG-TKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-------QSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNV-----CVEHCPLTTYVSLRG-TCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPD----VHHQECVPCPQGCHTCSNDQK-CIKCQAGWS 911
+Y NH+A+ + G A+A+R+A G+ N G IG L +++ F H R T S H L +P V W +QQ +RR KR + ++Y +DP++ + W+L+ G + S+MNVQ AW +GYTGK VVVTILDDGI+ +HPDL NYD AS D+NGND DP P+ ++ +NKHGTRCAGEVAA A N C VGIAYNA IGG+RMLDG V D VEA++L + PN+IDIYSASWGP+DDGKTVDGPG LAK+AF G+K GR G GSIFVWASGNGGR+ D C+CDGYTNSI+T+S+SSA++ G KPWYLEEC+STLA+TYSSG ++ I T D R CT HTGTS SAP+ AG+ ALALEAN LTWRD+QH++V TS PA L+ S W+VN G K SH +G+GL+DA A+V AK W Q +C + IP+ V R T T AC+ + + + YLEHV + S+ + RG L I L SPSGTKS LL R D++N GF +W F++VH WGE A G WTLE+ PS + + +G +K+W ++ YGT + P +S+++ P P ++ PED + + + S IL+ +S CHP+C C GP + +C +C +F G+V CV CPL + C+ CH C+TCS QCL+C + + + + C+ CP+G+ S C+ C C+ C + E C C++G S+ C+ C G + E C CH +C TC G +C C + + KCVP C G+ P+ + H+ C C + C +C+ + C +C+ G++
Sbjct: 69 VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA-FYERKIVTTDLRQR------CTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH-LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLV--QVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPS-QVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVE--VPEDEEDYTAQST--------------PGSANILQ--------------TSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVT-LCPAGFYADESQKNCLKCHPSCKKCVDEPEK---------------------CTVCKEGF--SLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFT 923 HSP 2 Score: 103.99 bits (258), Expect = 4.564e-21 Identity = 67/218 (30.73%), Postives = 108/218 (49.54%), Query Frame = 0
Query: 805 CLKCQKGLVRSV-LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFE--HKCVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSF---KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPD----VHHQECVPCPQGCHTCSNDQK-CIKCQAGWS 1010
CL C + SV KC++ CP G+ + R C CH+ C TC+ +TQC C G ++ + + CV CPAG+ D + C+ C C C ++ +KC C+ G+S A + +C P C G++ + C CH +C TC G +C C + + KCVP C G+ P+ + H+ C C + C +C+ + C +C+ G++
Sbjct: 712 CLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA--RGSCIPD----CEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFT 923 HSP 3 Score: 90.5077 bits (223), Expect = 6.548e-17 Identity = 74/249 (29.72%), Postives = 103/249 (41.37%), Query Frame = 0
Query: 925 AQCPEGSFKTRSCDPCHESCAT--CTGNLSTQCSLCLD---GTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQ--KCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTC--ESVSSCSQCGLDHFLTGSGKCSANCQGNEYQ-----TPNGLCLACNRSCEACMGPHSNECLSCRVG 1159
AQ GS CH C C G + QC C+ G+ KCV CP GY D + C C +GC TCS+ +C+ C+ G+ E C CP G ++ C C +C C D+ + C C + L SC+ +C GT++D++L C C H C TC C C +F KC C Y P+ +C C+ +C +C G N C C+ G
Sbjct: 680 AQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCV----TLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIP-DCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCA-KNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRN-CSRCKTG 921 HSP 4 Score: 87.4261 bits (215), Expect = 5.671e-16 Identity = 77/255 (30.20%), Postives = 106/255 (41.57%), Query Frame = 0
Query: 841 CHESCAT--CTGNLSTQCSLCLD---GTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQ--KCIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS---CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSN--DQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGL----CAPCGSTCNTCFDKADNCLSCPKNHVLDLSSCL-DHECPNG 1078
CH C C G + QC C+ G+ KCV CP GY D + C C +GC TCS+ +C+ C+ G+ E C CP G + S C CH SC C + +C++C +G C+PDC G D C C C TC ++CI C + F + K C P C EG + + + GL C C C +C + NC C +SC+ +H C N
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCV----TLCPAGFYADESQKNCLKCHPSCKKCV-DEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWK--CVPA----CGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNA 938 HSP 5 Score: 79.337 bits (194), Expect = 1.516e-13 Identity = 57/168 (33.93%), Postives = 70/168 (41.67%), Query Frame = 0
Query: 1111 HFLTGSGKCSANCQ-----GNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYL-STTGECLEECLHGFVDKNSQ--CQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC 1270
HF GS K S C G T C C++ CE C + +CLSCR G Y C+ C GF SQ C CH SC C +C+ C G L + CEP + D+ C CH +CGTC GP C+ C+ W CVP C
Sbjct: 717 HFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE-KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWK--CVPAC 881
BLAST of endoprotease furin vs. SwissProt
Match: gi|2499870|sp|Q63415.1|PCSK6_RAT (RecName: Full=Proprotein convertase subtilisin/kexin type 6; AltName: Full=Paired basic amino acid cleaving enzyme 4; AltName: Full=Subtilisin-like proprotein convertase 4; Short=SPC4; AltName: Full=Subtilisin/kexin-like protease PACE4; Flags: Precursor) HSP 1 Score: 583.178 bits (1502), Expect = 0.000e+0 Identity = 304/579 (52.50%), Postives = 388/579 (67.01%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDL-SDSMYISDPLFKDQWFLNHGAFDG---SDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNS--DNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSG-TKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR 590
+Y NH+A+ + G A+R+A G+ N G IG L +++ F H R T S H L +P V W +QQ +RR KR SDS+Y +DP++ + W+++ + S+MNVQ AW +GYTGK VVVTILDDGI+ +HPDL NYD AS D+NGND DP P+ ++ +NKHGTRCAGEVAA A N C VGIAYNA IGG+RMLDG V D VEA++L + PN+IDIYSASWGP+DDGKTVDGPG LAK+AF G+K GR G GSIFVWASGNGGR+ D+C+CDGYTNSI+T+S+SS ++ G KPWYLEEC+STLA+TYSSG ++ I T D R CT HTGTS SAP+ AG+ ALALEAN LTWRD+QH++V TS PA L+ S W+VN G K SH +G+GL+DA A+V A+ W Q +C IPV V R T T+AC+ + + + YLEHV +IS+ + RG L I L SPSGTKS LL R D +N GF +W F++VH WGE A G WTLEV PS + + +G +K+W ++ YGT + P R
Sbjct: 52 VYTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCADKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGA-FYERKIVTTDLRQR------CTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAH-LKASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHMCVATADKRPRSIPVV--QVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPS-QVRNPEKQGKLKEWSLILYGTAEHPYR 619 HSP 2 Score: 101.679 bits (252), Expect = 2.179e-20 Identity = 69/218 (31.65%), Postives = 105/218 (48.17%), Query Frame = 0
Query: 805 CLKC-QKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFE--HKCVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSF---KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPD----VHHQECVPCPQGCHTCSNDQK-CIKCQAGWS 1010
CL C L S KC++ CP G+ + R C CH+ C TCTG TQC C G ++ + + CV CPAG D + C+ C C C ++ +K C+ G+S A + +C P C G++ + C CH +C TC G +C C + + KCVP C G+ P+ + H+ C C + C +C + C +C+AG++
Sbjct: 680 CLNCVHFSLGNSKTNRKCVSECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCLRCHPSCQKCVDEPEKSTVCKEGFSLA--RGSCIP----DCEPGTYFDSELIRCGECHHTCRTCVGPSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSRNCSRCKAGFT 891 HSP 3 Score: 88.5817 bits (218), Expect = 2.717e-16 Identity = 70/234 (29.91%), Postives = 98/234 (41.88%), Query Frame = 0
Query: 940 CHESCAT--CTGNLSTQCSLCLD---GTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQ--KCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTC--ESVSSCSQCGLDHFLTGSGKCSANCQGNEYQ-----TPNGLCLACNRSCEACMGPHSNECLSCRVG 1159
CH C C G + QC C+ G KCV +CP GY D + C C +GC TC+ +C+ C+ G+ E C CP G ++ LC C +C C D+ + C + L SC+ +C GT++D++L C C H C TC S C C F KC C Y P+ +C C+ +C +C G N C C+ G
Sbjct: 663 CHPECGDKGCDGPSADQCLNCVHFSLGNSKTNRKCVSECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCV----TLCPAGLYADESQRLCLRCHPSCQKCVDEPEKSTVCKEGFSLARGSCIP-DCEPGTYFDSELIRCGECHHTCRTCVGPSREECIHCA-KSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSRN-CSRCKAG 889 HSP 4 Score: 85.1149 bits (209), Expect = 2.630e-15 Identity = 75/255 (29.41%), Postives = 105/255 (41.18%), Query Frame = 0
Query: 841 CHESCAT--CTGNLSTQCSLCLD---GTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQ--KCIKCQAGWSFANEKEACSPQANAQCPEGSF---KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCS--NDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGL----CAPCGSTCNTCFDKADNCLSCPKNHVLDLSSCL-DHECPNG 1078
CH C C G + QC C+ G KCV +CP GY D + C C +GC TC+ +C+ C+ G+ E C CP G + R C CH SC C + + ++C +G C+PDC G D C C C TC + ++CI C + F + K C P C EG + + + GL C C C +C + NC C +SC+ +H C N
Sbjct: 663 CHPECGDKGCDGPSADQCLNCVHFSLGNSKTNRKCVSECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCV----TLCPAGLYADESQRLCLRCHPSCQKCV-DEPEKSTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCRTCVGPSREECIHCAKSFHFQDWK--CVPA----CGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSRNCSRCKAGFTQLGTSCITNHTCSNA 906 HSP 5 Score: 74.3294 bits (181), Expect = 5.224e-12 Identity = 54/168 (32.14%), Postives = 68/168 (40.48%), Query Frame = 0
Query: 1111 HFLTGSGKCSANCQ-----GNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYL-STTGECLEECLHGFVDKNSQ--CQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC 1270
HF G+ K + C G T C C++ CE C G +CLSCR G Y T C+ C G SQ C CH SC C + + C G L + CEP + D+ C CH +C TC GP C+ C+ W CVP C
Sbjct: 685 HFSLGNSKTNRKCVSECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCLRCHPSCQKCVDEPE-KSTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCRTCVGPSREECIHCAKSFHFQDWK--CVPAC 849 HSP 6 Score: 70.4774 bits (171), Expect = 9.361e-11 Identity = 66/232 (28.45%), Postives = 101/232 (43.53%), Query Frame = 0
Query: 991 QGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKA-DNCLSCPKN--HVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQ-GNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDK------NSQCQACHSSCLACTGPSLFQCSTCPSG-TKLG 1211
+GC S DQ C+ C +S N K + + ++CP G F C C C TC ++ CLSC + H + ++C+ CP G + D C C +C C S + F G C +C+ G + + C C+ +C C+GP EC+ C + +C+ C GF + + C+ C +CL+C G S CS C +G T+LG
Sbjct: 670 KGCDGPSADQ-CLNC-VHFSLGNSKT--NRKCVSECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCVT-LCPAGLYADESQRLCLRCHPSCQKCVDEPEKSTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCRTCVGPSREECIHC-AKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSR-NCSRCKAGFTQLG 894 HSP 7 Score: 59.6918 bits (143), Expect = 1.551e-7 Identity = 70/244 (28.69%), Postives = 98/244 (40.16%), Query Frame = 0
Query: 1053 ADNCLSCPKNHVLDLSS---CLDHECPNGTFYDTQLNECRHCPHNCMTCESVS-----SCSQCGLDHFLTGS--GKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHG--FVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSC----EPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVP--CCESSDEKHC 1278
AD CL+C + + + C+ ECP G F DT CR C C TC S SC + H T + C A +E Q LCL C+ SC+ C+ + C+ G L+ G C+ +C G F + +C CH +C C GPS +C C +C P + C C E+C +C G N C C T+C+ C ++DE C
Sbjct: 677 ADQCLNCVHFSLGNSKTNRKCVS-ECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCVTLCPAGLYADESQR---LCLRCHPSCQKCVDEPEKSTV-CKEGFSLAR-GSCIPDCEPGTYFDSELIRCGECHHTCRTCVGPSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSRN-CSRCKAGFT--QLGTSCITNHTCSNADETFC 911
BLAST of endoprotease furin vs. SwissProt
Match: gi|120608|sp|P29119.1|FURI1_XENLA (RecName: Full=Furin-1; AltName: Full=Dibasic-processing enzyme; AltName: Full=Paired basic amino acid residue-cleaving enzyme; Short=PACE; Flags: Precursor) HSP 1 Score: 582.793 bits (1501), Expect = 0.000e+0 Identity = 310/574 (54.01%), Postives = 379/574 (66.03%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDLSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDN--SDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPL 589
K+Y N +A HI G A+A+R+ GF N G I +H+ F H + R +L +EP VHW EQQ ++R KRD+ +DP F QW+L + D++V+ AW +G+TGK +VV+ILDDGI+ +HPDL+ NYDP AS D+N D DP P+ +DN+HGTRCAGEVAA A NGICGVGIAYNA+IGGVRMLDG V DAVEAR+L LNPNHI IYSASWGPEDDGKTVDGP LA++AF GV GR G GSI+VWASGNGGR+ D+CNCDGYTNSI+TLSISS +Q G PWY E CSSTLA+TYSSG ++ I T D LR + CT SHTGTSASAP+AAG+ ALALEAN NLTWRDMQH+VV TSNPA L + W N VGRK SH +GYGL+DA AMV +AK W G Q D LS P + G V K + C+G I LEHVQ ++SL Y+ RG L I LTSP GT+S LL PRP D + GF DW F++ H W E G W LE+ + + + G + ++ ++ YGT L
Sbjct: 26 KVYTNTWAAHISGGSAEADRLCKKYGFINHGLI--FEDHYHFSHRAVMKRSLTPKRTRQVLLKREPQVHWLEQQVAKKRKKRDIYTDP--TDPKFMQQWYLLDT--NRHDLHVKEAWEQGFTGKGIVVSILDDGIEKNHPDLQANYDPAASYDVNDQDPDPQPRYTQLNDNRHGTRCAGEVAAVANNGICGVGIAYNANIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPAKLAEEAFYRGVTQGRGGLGSIYVWASGNGGREHDSCNCDGYTNSIYTLSISSTTQMGNVPWYSEACSSTLATTYSSGNQ-NEKQIVTTD----LR--QKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVQTSNPAG-LNANDWITNGVGRKVSHSYGYGLLDAGAMVAMAKTWVTVGPQRKYVIDILSE----PKDIGKALEVRRKVEPCAGMSNYISTLEHVQARLSLSYNCRGDLAIYLTSPMGTRSCLLAPRPHDYSADGFNDWSFMTTHSWDEDPAGEWVLEIENVSNNNN-----YGTLTQFVLVLYGTASEGL 576
BLAST of endoprotease furin vs. SwissProt
Match: gi|2499869|sp|Q28193.1|FURIN_BOVIN (RecName: Full=Furin; AltName: Full=Dibasic-processing enzyme; AltName: Full=Paired basic amino acid residue-cleaving enzyme; Short=PACE; AltName: Full=Trans Golgi network protease furin; Flags: Precursor) HSP 1 Score: 571.237 bits (1471), Expect = 0.000e+0 Identity = 309/592 (52.20%), Postives = 379/592 (64.02%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDLSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQ--DNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFG 607
K++ N +A+HIP G A A+R+A GF N G I +++ F H + R + H L +EP V W EQQ +RR KRD+ +DP F QW+L+ D+NV+ AWA+GYTG+ +VV+ILDDGI+ +HPDL NYDP AS D+N D DP P+ +DN+HGTRCAGEVAA A NG+CGVG+AYNA IGGVRMLDG V DAVEAR+L LNPNHI IYSASWGPEDDGKTVDGP LA++AF GV GR G GSIFVWASGNGGR+ D+CNCDGYTNSI+TLSISSA+Q G PWY E CSSTLA+TYSSG ++ I T D LR + CT SHTGTSA AP+AAG+ AL LEAN NLTWRDMQH+VV TS PA L + W N VGRK SH +GYGL+DA AMV +A+ W Q C D L+ P + G V AC G I LEH Q +++L Y+ RG L I L SP GT+S+LL RP D + GF DW F++ H W E +G W LE+ ++ + G + K+ ++ YGT L P P E G
Sbjct: 28 KVFTNTWAVHIPGGPAVADRVARKHGFLNLGQI--FGDYYHFWHRAVTKRSLSPHRLGHNRLQREPQVKWLEQQVAKRRAKRDIYQEP--TDPKFPQQWYLS--GVTQRDLNVKEAWAQGYTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPAHLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQ-NEKQIVTTD----LR--QKCTESHTGTSAFAPLAAGIIALTLEANKNLTWRDMQHLVVRTSKPAH-LNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCTIDILTE----PKDIGKRLEVRKTVTACLGEPSHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANN-----YGTLTKFTLVLYGTAPEGL----------PTPPESIG 586
BLAST of endoprotease furin vs. SwissProt
Match: gi|341940726|sp|P23188.2|FURIN_MOUSE (RecName: Full=Furin; AltName: Full=Dibasic-processing enzyme; AltName: Full=Paired basic amino acid residue-cleaving enzyme; Short=PACE; AltName: Full=Prohormone convertase 3; Flags: Precursor) HSP 1 Score: 571.237 bits (1471), Expect = 0.000e+0 Identity = 305/569 (53.60%), Postives = 372/569 (65.38%), Query Frame = 0
Query: 18 KIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRDLSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQ--DNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGT 584
KI+ N +A+HIP G A A+R+A GF N G I +++ F H + R + H L +EP V W EQQ +RR KRD+ +DP F QW+L+ D+NV+ AWA+G+TG +VV+ILDDGI+ +HPDL NYDP AS D+N D DP P+ +DN+HGTRCAGEVAA A NG+CGVG+AYNA IGGVRMLDG V DAVEAR+L LNPNHI IYSASWGPEDDGKTVDGP LA++AF GV GR G GSIFVWASGNGGR+ D+CNCDGYTNSI+TLSISSA+Q G PWY E CSSTLA+TYSSG ++ I T D LR + CT SHTGTSASAP+AAG+ AL LEAN NLTWRDMQH+VV TS PA L W N VGRK SH +GYGL+DA AMV +A+ W Q C + L P + G V AC G I LEHVQ +++L Y+ RG L I L SP GT+S+LL RP D + GF DW F++ H W E G W LE+ ++ + G + K+ ++ YGT
Sbjct: 28 KIFTNTWAVHIPGGPAVADRVAQKHGFHNLGQI--FGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDVYQEP--TDPKFPQQWYLS--GVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQ-NEKQIVTTD----LR--QKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAH-LNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVE----PKDIGKRLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEANN-----YGTLTKFTLVLYGT 573
BLAST of endoprotease furin vs. nr
Match: gi|1209696022|gb|OWR48567.1| (Endoprotease FURIN [Danaus plexippus plexippus]) HSP 1 Score: 1020.76 bits (2638), Expect = 0.000e+0 Identity = 571/1216 (46.96%), Postives = 709/1216 (58.31%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVS--WSSGSFSTRAHS---GGILEHNKGQSGLLDYESPS--SSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS-CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVS--SCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC-RVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPS 1197
+YHNHFA+H+P GE A+ IA GF N G IG L ++L H + R T S EHH L EP V WFEQQ ERRR KRD ++ S + SDPLFK+QW+LN GA DG DMNV PAW +GYTGK VVV+ILDDGIQT+HPDL +NYDPLASTDINGND+DPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLASTYSSGTPGHD S+ATVD D RLR D ICT HTGTSASAP+AAG+CALALEANPNLTWRDMQ++VV+TS P PL +E+GW VN V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D I + G +V + + CSGT E+RYLEHVQCKISL + PRG L I+LTSP GT SSLL RPRD+ + F+DWPFLSVHFWGE A G WTL++ ++ + GI+KKW+++FYGT P+R L S+ + F + + + +N N Q+ +++GS +A + G + G++ L D C P+C+ C T+C +C++++ + CV CP ++ + G C CH +C+TC GP + CLTCS + L++D CI+ QCP GY + + C PC HC +C+E ++ C C+ LV + C CP + E SC CHESC TC G C C ++ + +C+ CP+GY D +EC+ CP GC TC C C + W N K C + +C G F S C CH C +C G C C HKCVP+C GY + C C GC C++ C C S C EG ++ G C+ C +C TC + D C SCP+ L C ECP G FY T + CRHC H C C+ C+ C F+ G C Y++ +GLC +C+ SC C GP C +C R + +C++ C + S C C S C S
Sbjct: 24 LYHNHFAIHVPAGEKHADDIATRHGFINHGQIGALKGYYLLSHHGVHKRSTEPSHEHHHKLNNEPEVKWFEQQRERRRMKRDYSPYESTLWSQLSRRLPSHRTRHRAITPSPFFSDPLFKEQWYLNGGAKDGLDMNVMPAWQRGYTGKGVVVSILDDGIQTNHPDLAQNYDPLASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGFKPWYLEECSSTLASTYSSGTPGHDKSVATVDMDGRLRSDHICTVEHTGTSASAPLAAGICALALEANPNLTWRDMQYLVVLTSRPQPLEKETGWIVNGVKRKVSHKFGYGLMDASEMVNLAEQWVSVPPQHICKSQEINEDKAIESSFGYTLKVHMDVNGCSGTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTTSSLLFERPRDVISSNFDDWPFLSVHFWGERAEGRWTLQIVNAGNRHVNQ---PGILKKWQLIFYGTSTDPIR---LRSKRPAQAAPAFAFPTAADGYEAAGDSFYNTDAFTNYQNFPSLFAAGSNPEKAIARLDGHNVPSPHGENVLADSNDKRVMHDCDPECDSQGCYEKGPTQCIACKHYRLDDACVSRCPPRSFANQGGVCWPCHETCETCVGPGQDSCLTCSPAHLLVADLGLCIQ-QCPDGYWENSEASACRPCAAHCSTCSERAD---------------------ACTSCEHHLV--LYNGTCATSCPPS-TYETEDYSCAKCHESCNTCHGPGEQHCVTCPASSYVLDGRCLSTCPSGYYADKKRKECMKCPIGCATCLA-SLCQSCNSNWEL-NRKGKCVAAGSDRCNAGEFSDGSQCQLCHNDCDSCYGETEGNCLTCPSPNLLQNHKCVPECSRGYYSEA--GRCTRCIHGCSECASRLNCTFCTGSLRLQ------SGTCRTACAEGYYADR--GTCSKCYLSCATCIGPRRDQCASCPRGWRLAAGEC-HPECPQG-FYKTA-DGCRHCHHYCRECDGSGPLHCTSCP-QRFMLDGGLCMECLSSQYYESSSGLCRSCHESCRICSGPGQYSCTACSRPLRLDRLNNQCVQCCSERANNATSDCCHCDSDTGECINSS 1192 HSP 2 Score: 223.016 bits (567), Expect = 3.931e-55 Identity = 162/485 (33.40%), Postives = 218/485 (44.95%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHK--CVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR--SCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCE---SSDEKHCCSCTPSRDKCLQPS 1292
L++ C++ CP S + C PCHE+C TC G C C C+ CP GY + C PC C TCS C C+ N A S CP +++T SC CHESC TC G C C ++ + +C+ CP+GY D +EC+ CP GC TC C C + W N K C + +C G FS G C C + C++C+ + + NCL+CP ++L C+ EC G Y ++ C C H C C S +C+ C L SG C C Y G C C SC C+GP ++C SC G L+ GEC EC GF C+ CH C C G C++CP L C+ C +++++ S C +CHESC CSGP C +CS PL LD N CV CC ++ CC C +C+ S
Sbjct: 726 LDDACVSRCP-PRSFANQGGVCWPCHETCETCVGPGQDSCLTCSPAHLLVADLGLCIQQCPDGYWENSEASACRPCAAHCSTCSERADACTSCEHHLVLYNGTCATS------CPPSTYETEDYSCAKCHESCNTCHGPGEQHCVTCPASSYVLDGRCLSTCPSGYYADKKRKECMKCPIGCATCLA-SLCQSCNSNWEL-NRKGKCVAAGSDRCNAGEFSD--GSQCQLCHNDCDSCYGETEGNCLTCPSPNLLQNHKCVP-ECSRG--YYSEAGRCTRCIHGCSECASRLNCTFCTGSLRLQ-SGTCRTAC-AEGYYADRGTCSKCYLSCATCIGPRRDQCASCPRGWRLAA-GECHPECPQGFYKTADGCRHCHHYCRECDGSGPLHCTSCPQRFMLD-GGLCMECLSSQYYESSSGLCRSCHESCRICSGPGQYSCTACSRPLRLDRLNNQCVQCCSERANNATSDCCHCDSDTGECINSS 1192
BLAST of endoprotease furin vs. nr
Match: gi|512908708|ref|XP_004926747.1| (furin-like protease 2 [Bombyx mori] >gi|1200724312|ref|XP_021204031.1| furin-like protease 2 [Bombyx mori]) HSP 1 Score: 1015.37 bits (2624), Expect = 0.000e+0 Identity = 557/1178 (47.28%), Postives = 692/1178 (58.74%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGP---LPSEDFG-DGLPGKMMDGSPEDGHNVSPN------NNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR-SCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVS--SCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC 1156
+YHNHFA+H+P G + I G+ N G IG+L N++L H + R T S EHH L EP V WFEQQHE+RRFKRD LS Y +DPL+K+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYDPLASTDINGND+DPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D RLR D ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV+TS P PL RE GW +N V RK SHKFGYGLMDA+ MV +A+ W Q IC++ L+ D + G+ R + CSGT E+RYLEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTLE+ ++ G++KKW+++FYGT P+R +S+ S F P P+ G D + + + PN N + V+ G H +L + + + D C P+C+ C G ++C +C++++ + CV CP +Y + G C CH SC+TC GP + C TC+ + FL++D + C++ QCP GY + C PC HC +C+E + C C+ L+ + E CL CP + +C CH SC TC G QC C + + CV CP GY D +ECV CP GC TC++ C+ C+ W N+K C P + +C G F + C C ++C +C G C C +++CVP+C +GY + C+ C GC C + C C S + AC C +G ++ G C+ C +C TC + D C SCP+ L C ECP G FY + + CRHC H C C C+ C L G G C Y+ NG C C+ SC C G C C
Sbjct: 24 VYHNHFAVHVPSGPEHVDDIVRRHGYVNHGQIGSLKNYYLLSHHEVHKRSTEPSHEHHSKLRDEPQVAWFEQQHEKRRFKRDYNAYDRASFGQLPRRTSPHRAHNRALSSQPYFTDPLYKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPLASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNRYCGVGIAYNASIGGVRMLDGIVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRADHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVMTSRPEPLEREKGWIINGVKRKVSHKFGYGLMDATEMVNLAEQWVTVPPQHICKSQELNEDKSMDSTLGNSLRTYMDVTGCSGTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTVSTLLFERPRDVASSTFDDWPFLSVHFWGEQAEGRWTLEIINAGKRHVNQA---GVLKKWQLIFYGTVIDPVRLRSKRPSPFAPSYAFPTAADGYDTISDSFYNTDAFANYQNFPNLFAAGSNPEKAVARLDGHNVPSPHGENVLADSNDKRVMHD-------CDPECDSQGCYGKGPSQCVACKHYRLDDTCVSRCPPRSYANQGGVCWQCHESCETCMGPGQDSCFTCAPAHFLVADLAVCLQ-QCPDGYWEDTDSATCRPCAAHCATCSERAN---------------------ACTSCEHHLL--LHEGSCLVTCPAAH-YETDDYTCAKCHNSCDTCVGPKENQCITCHTTNYVLDGSCVATCPGGYYVDKKRKECVRCPVGCATCTS-AFCLTCETNWEI-NKKGRCLPAGSDRCSTGQFIDKLGCSRCDDACESCYGEGEGHCLTCPSPNLLEDYRCVPECSSGYYAEA--GRCIRCVHGCTECVSRLNCTSCAG--SLRLQSGAC----RTSCADGYYADR--GACSKCYLSCRTCIGPRRDQCASCPQGWRLAAGEC-HPECPQG-FYKSD-DGCRHCHHYCRECSDSGPLHCTSCPPRFVLDG-GLCMECLGSQYYEAGNGTCSTCDPSCRTCYGSGQFSCTGC 1150 HSP 2 Score: 225.713 bits (574), Expect = 5.752e-56 Identity = 171/537 (31.84%), Postives = 238/537 (44.32%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSFKT--RSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC-----ESSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFGL-----GDEALTNPSRSLFHYGSLLAILALMTLVIV 1337
L++ C++ CP N + C CHESC TC G C C F C+ CP GY D C PC C TCS C C+ + +C CP ++T +C CH SC TC G QC C + + CV CP GY D +ECV CP GC TC++ C+ C+ W N+K C P + +C G F LG C+ C C +C+ + + +CL+CP ++L+ C+ EC +G Y + C C H C C S +C+ C L SG C +C + Y G C C SC C+GP ++C SC G L+ GEC EC GF + C+ CH C C+ C++CP L C+ C ++++A + C C SC TC G C CS PL LD N CVPCC +S CC C P +C+ S ++ KR +G + + PS + L+ AL +V++
Sbjct: 726 LDDTCVSRCPPRSYAN-QGGVCWQCHESCETCMGPGQDSCFTCAPAHFLVADLAVCLQQCPDGYWEDTDSATCRPCAAHCATCSERANACTSCEH--HLLLHEGSCL----VTCPAAHYETDDYTCAKCHNSCDTCVGPKENQCITCHTTNYVLDGSCVATCPGGYYVDKKRKECVRCPVGCATCTS-AFCLTCETNWEI-NKKGRCLPAGSDRCSTGQFIDKLG--CSRCDDACESCYGEGEGHCLTCPSPNLLEDYRCVP-ECSSG--YYAEAGRCIRCVHGCTECVSRLNCTSCAGSLRLQ-SGACRTSC-ADGYYADRGACSKCYLSCRTCIGPRRDQCASCPQGWRLAA-GECHPECPQGFYKSDDGCRHCHHYCRECSDSGPLHCTSCPPRFVLD-GGLCMECLGSQYYEAGNGTCSTCDPSCRTCYGSGQFSCTGCSRPLRLDRLNNQCVPCCTDRGTTTSPGTECCHCHPETGECINSS---VAGKRRIAEWGALHTVENARSTSAPSAAAITVMVCLSAGALFFVVLM 1241
BLAST of endoprotease furin vs. nr
Match: gi|1344813435|ref|XP_023949719.1| (furin-like protease 2 [Bicyclus anynana]) HSP 1 Score: 1008.82 bits (2607), Expect = 0.000e+0 Identity = 573/1219 (47.01%), Postives = 701/1219 (57.51%), Query Frame = 0
Query: 20 YHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-----------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVS--WSSGSFSTRAHS---GGILEHNKGQSGLLDYESPSS--SCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKT-RSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC-RVGKYLSTTGECLEECLHGFVDKN----SQCQACHSSCLACTGPSL 1198
YHNHFA+ +P G + + IA GF N G IG L + +L H + R T S +HH LI EP V WFEQQ E+RR KRD ++ S + DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYDP ASTDINGND+DPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLASTYSSGTPGHD S+ATVD D RLR D ICT HTGTSASAP+AAG+CALALEANP+LTWRDMQ++VV+TS P PL +E+GW VN V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D PI G V + + CSGT E+RYLEHVQCKISL + PRG L I+LTSP T SSLL RPRD+ + F+DWPFLSVHFWGE A G WTL++ ++ + GI+KKW+++FYGT P+R +S+ S P +G D + +N N Q+ +++GS +A + G + G++ L D +C P+C+ C G T+C SC++++ + CV CP +Y + G C CH C+TC GP + CLTC+ + L++D C + QCP GY + + C PC HC +C+E + +C C+ LV + C CP + + SC CH SC TC+G QC C + + CV CP GY D +EC+ CP GC TC C+ C + W N+K C + QC F +C CH C +C G C C HKCV +C GY P+ C C GC +C++ C C S + AC A C G ++ C C +C TC + D C SCP L C ECP G FY T + CRHC H C C C+ C F+ G C T NG C AC+ SC C GP N C C R K +C+ C V N S C CH C S+
Sbjct: 25 YHNHFAVRVPGGVHRVDDIAKRHGFVNHGQIGALPDFYLLSHHEVHKRSTEPSHDHHHKLINEPHVKWFEQQREKRRIKRDYNQDSLLSQISRRLSPHRTRHRAITSSPFFPDPLFKEQWYLNGGAKDGLDMNVSPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPQASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLASTYSSGTPGHDKSVATVDMDGRLRADHICTVEHTGTSASAPLAAGICALALEANPDLTWRDMQYLVVLTSRPQPLEKENGWIVNGVKRKVSHKFGYGLMDASEMVNLAEQWITVPPQHICKSQEINEDKPIDPTYGYTLSVHMDVNGCSGTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMQTTSSLLFERPRDVVSSNFDDWPFLSVHFWGERAEGRWTLQIVNAGNRHVNQ---PGILKKWQLIFYGTASDPVRLRSKRPSALVP----PYGFPTAADGYDSVGDSFYNTDAFTNYQNFPTLFAAGSDPEKAVAQLDGHNIPSPHGENVLADSNDRRVMYNCDPECDSQGCYGSGPTQCISCKHYRLDDACVSRCPPRSYANQGGVCWPCHEYCETCVGPGQDSCLTCAPAYLLVADLGVCTQ-QCPDGYWEDNDSSSCRPCASHCSTCSERAH---------------------LCTSCEHHLV--LYNGTCSASCPPS-TYETDDYSCAKCHTSCDTCSGPGEKQCITCHASNYILDGSCVSTCPGGYYADKKRKECMKCPLGCSTCLA-TFCLSCNSNWEL-NKKGKCVAAGSDQCTSSEFSDGANCKNCHTDCESCYGETEANCLTCPSPYLLQNHKCVMECSRGYYPEA--GRCARCLHGCASCASRLNCTTCSD--SLKLQSGAC----RASCAAGYYADR--STCTKCYISCRTCIGPRRDQCGSCPSGWKLAAGEC-HPECPQG-FYQTD-DGCRHCHHYCRECNGSGPLHCTSCP-PRFMLDGGLCMECLSSQYLDTSNGTCHACDASCRTCSGPGQNSCTGCARPLKLDKLNNQCVRCCSELGVSANSTPPSDCCHCHPDTGECMSSSI 1195 HSP 2 Score: 243.047 bits (619), Expect = 2.033e-61 Identity = 182/545 (33.39%), Postives = 243/545 (44.59%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQK-CIKCQAGWSFANEKEACSPQANAQCPEGSFKT--RSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC-------ESSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFGLGDEALTNPSRSLFHYGSLLAILALMTL-VIVKYFKRAKIRL 1347
L++ C++ CP N + C PCHE C TC G C C C CP GY D C PC C TCS C C+ N CS A CP +++T SC CH SC TC+G QC C + + CV CP GY D +EC+ CP GC TC C+ C + W N+K C + QC FS G C C + C +C+ + + NCL+CP ++L C+ EC G Y + C C H C +C S +C+ C D SG C A+C Y C C SC C+GP ++C SC G L+ GEC EC GF + C+ CH C C G C++CP L C+ C ++ D + C AC SC TCSGP N C C+ PL LD N CV CC S+ CC C P +C+ S + ++R+S L A P+ SLF ++AL+ L V+V +R++ +L
Sbjct: 724 LDDACVSRCPPRSYAN-QGGVCWPCHEYCETCVGPGQDSCLTCAPAYLLVADLGVCTQQCPDGYWEDNDSSSCRPCASHCSTCSERAHLCTSCEHHLVLYNG--TCS----ASCPPSTYETDDYSCAKCHTSCDTCSGPGEKQCITCHASNYILDGSCVSTCPGGYYADKKRKECMKCPLGCSTCLA-TFCLSCNSNWEL-NKKGKCVAAGSDQCTSSEFSD--GANCKNCHTDCESCYGETEANCLTCPSPYLLQNHKCV-MECSRG--YYPEAGRCARCLHGCASCASRLNCTTCS-DSLKLQSGACRASCAAG-YYADRSTCTKCYISCRTCIGPRRDQCGSCPSGWKLAA-GECHPECPQGFYQTDDGCRHCHHYCRECNGSGPLHCTSCPPRFMLD-GGLCMECLSSQYLDTSNGTCHACDASCRTCSGPGQNSCTGCARPLKLDKLNNQCVRCCSELGVSANSTPPSDCCHCHPDTGECM--SSSIAGKRRNSESAALHTVASERPA-SLFSIVIAGGVVALVVLSVMVVQLRRSRHQL 1247
BLAST of endoprotease furin vs. nr
Match: gi|1229700120|ref|XP_022130459.1| (furin-like protease 2 [Pieris rapae]) HSP 1 Score: 1008.82 bits (2607), Expect = 0.000e+0 Identity = 559/1174 (47.61%), Postives = 702/1174 (59.80%), Query Frame = 0
Query: 20 YHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLRQS-QLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVS--WSSGSFSTRAHS---GGILEHNKGQSGLLDYESPSS--SCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSF-KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC 1156
YHNHFA+ + +G + IAL GF+N G IG+L +L H + R S EHH+ L EP V WFEQQ ERRR KRD ++ S++ DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL++NYD LASTDINGND+DPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD DARLRPD+ICT HTGTSASAP+AAG+CALALEANP+LTWRDMQ++VV+TS P PL +ESGW VN + RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D I + G + + CSGT E+R+LEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTL++ ++ + GI+KKW+++FYGT P+R S + S G P F G+ G D + +N N Q+ +++GS +A + G + G++ L D C P+C+ C G T+C +C++++ + CV CP ++ + G C CH SC+TC GP + CLTC+ + L++D + C++ QCP GY + + C C HC +C++ ++ C C+ LV + C+ CP + E SC CH SC TC G QC C + + +CV CP+ Y D +EC+ CP GC C + C+ C W N+K C P N +C G F + +C C+E+C TC G C C +KCV +C GY P+ C C GC C++ C C+ S + AC C EG ++ G+C+ C +C TC + D C SCP L C ECP G FY T+ + CRHC H C C+ C C L G G C Y +G C +C+ SC C GP C C
Sbjct: 25 YHNHFAIQVLDGPEHVDDIALRHGFENHGQIGSLKGFYLLSHHKVHKRSLEPSHEHHKKLNDEPQVRWFEQQRERRRVKRDYKPYEGALWSQLARRPASHRTRHRAITPSLF-PDPLFKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLKQNYDALASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNQYCGVGIAYNASIGGVRMLDGIVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDARLRPDRICTVEHTGTSASAPLAAGICALALEANPDLTWRDMQYLVVMTSRPQPLEKESGWIVNGIKRKVSHKFGYGLMDASEMVNLAEQWISVPPQHICKSQEINEDKAIDSSYGYTLKAHMDVTGCSGTVNEVRFLEHVQCKISLRFFPRGNLRILLTSPMGTTSTLLFERPRDVVSSNFDDWPFLSVHFWGERAEGRWTLQIVNAGNRHVNQ---PGILKKWQLIFYGTNVDPVRLSTKRPSALG--PPFGFPTGVDG--YDTVGDSFYNTDAFTNYQNFPSLFAAGSDPEKAIARLDGHNIPSTHGENVLADSNDKRVMHDCDPECDAQGCYGKGPTQCIACKHYRLDDACVSRCPPRSFANQGGVCWPCHESCETCIGPGQDSCLTCAPAHLLVADLAVCLQ-QCPDGYYEDSDASVCRACAMHCSTCSDRAD---------------------ACTSCEHHLV--LYNGTCVASCP-PTTYETEDDSCANCHTSCDTCMGPGPVQCITCHPSNYILDGRCVNSCPSAYYADKKRKECLKCPVGCSNCLS-SFCLSCDTNWEL-NKKGKCLPVGNDRCSAGEFSSSNTCQNCNEACDTCYGEDEKNCLTCPAPNLLQNYKCVSECGRGYYPEA--GRCAKCVHGCSQCASRLNCTSCEG--SLRLQSGAC----RTSCAEGYYADR--GVCSKCYLSCRTCSGPRRDQCASCPSGWRLAAGECYP-ECPQG-FYKTE-DGCRHCHHYCRECDGSGPLHCKSCPPGFMLDG-GLCMECLGSQYYDKSSGTCHSCHDSCRTCSGPGQFSCTGC 1149 HSP 2 Score: 244.202 bits (622), Expect = 8.805e-62 Identity = 174/536 (32.46%), Postives = 232/536 (43.28%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR--SCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCF-DKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCESSDEK---------HCCSCTPSRDKCLQPSKKMLSRKRSSVRFGLGDEALTNPSRSLFHYGSLLAILALMTLVIV 1337
L++ C++ CP S + C PCHESC TC G C C C+ CP GY D C C C TCS+ C C+ N A CP +++T SC CH SC TC G QC C + + +CV CP+ Y D +EC+ CP GC C + C+ C W N+K C P N +C G FS + C C C+TC+ + NCL+CP ++L C+ EC G Y + C C H C C S +C+ C L SG C +C Y G+C C SC C GP ++C SC G L+ GEC EC GF C+ CH C C G C +CP G L C+ C +++D S C +CH+SC TCSGP C CS PL D N CVPCC S + CC C P C+ S ++ KR +G + PS++ + G + + ++V
Sbjct: 725 LDDACVSRCP-PRSFANQGGVCWPCHESCETCIGPGQDSCLTCAPAHLLVADLAVCLQQCPDGYYEDSDASVCRACAMHCSTCSDRADACTSCEHHLVLYNGT------CVASCPPTTYETEDDSCANCHTSCDTCMGPGPVQCITCHPSNYILDGRCVNSCPSAYYADKKRKECLKCPVGCSNCLS-SFCLSCDTNWEL-NKKGKCLPVGNDRCSAGEFSSS--NTCQNCNEACDTCYGEDEKNCLTCPAPNLLQNYKCVS-ECGRG--YYPEAGRCAKCVHGCSQCASRLNCTSCEGSLRLQ-SGACRTSC-AEGYYADRGVCSKCYLSCRTCSGPRRDQCASCPSGWRLAA-GECYPECPQGFYKTEDGCRHCHHYCRECDGSGPLHCKSCPPGFMLD-GGLCMECLGSQYYDKSSGTCHSCHDSCRTCSGPGQFSCTGCSRPLRFDRLNNQCVPCCSESSQAANSTPASTPDCCHCHPDTGDCINSS---VAGKRRIAEWGALQSSNDTPSKTPLNPGMMFLVFIAAGTIVV 1239
BLAST of endoprotease furin vs. nr
Match: gi|1274120639|ref|XP_022824388.1| (furin-like protease 2 [Spodoptera litura] >gi|1274120641|ref|XP_022824389.1| furin-like protease 2 [Spodoptera litura]) HSP 1 Score: 1005.36 bits (2598), Expect = 0.000e+0 Identity = 552/1178 (46.86%), Postives = 699/1178 (59.34%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGP---LPS-----EDFGDGLPGKMMDGSPEDGHNV--SPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKT-RSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC 1156
+YH+ FA+H+P G + IA GF N G IG+L N++L H +R R T S EHH+ L EP V WFEQQ E+RR KRD L+ S + DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYDP ASTDINGND+DPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D RLR D ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV+TS P PL +E GW +N V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D I G + + CS T E+RYLEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTL++ ++ + G++KKW+++FYGT P+R +++ S P P+ E GD + ++ N+ + ++ + V+ G H +L + + + D C P+C+ C G T+C +C++++ + CV CP +Y + G C CH SC+TC GP + CLTC+ + L++D + C++ QCP GY + + C PC HC +C+E ++G C C+ LV + + C+ CP E C CHESC TC G TQC C T+ + +CV CP Y D +EC+ CP GC TC++ C+ C++ W N+K C P + +C G F + C C+ +C +C G C C + ++KCVP+C GY + C C GC C + C C + + AC C +G ++ G C+ C +C TC + D C SCP+ L C ECP G FY + L CRHC H C C+ C C F+ G C Y +G C +C+ SC C GP C +C
Sbjct: 24 VYHDQFAVHVPAGSHHVDDIARRHGFVNHGQIGSLKNYYLLSHHEVRKRSTEPSHEHHKKLNDEPQVRWFEQQREKRRIKRDYSPYDRAAFSQLSRRLQPHRPHYRALTSSPFFPDPLFKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPNASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRSDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVMTSRPQPLEKEGGWIINGVKRKVSHKFGYGLMDASEMVSLAEQWVSVPPQHICKSQEINEDKQIESTFGYTLSTHMDVNGCSSTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTVSTLLFERPRDVVSSNFDDWPFLSVHFWGEHAEGRWTLQIVNAGNRHVNQA---GLLKKWQLIFYGTAVDPVRLRTKRPSPVAPPFAFPTAADGYETIGDSFYNTDAFANYQNFPNLFAAGSDPEKAVARLDGHNVPSPHGENVLADSNDKRVMHD-------CDPECDSQGCYGKGPTQCIACKHYRLDDSCVSRCPPRSYANQGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQ-QCPDGYWEDSEASVCRPCAAHCATCSERADG---------------------CTSCEHHLV--LHDGTCMASCPPSH-YETEDDMCAKCHESCDTCQGPGETQCVTCHPSTYALDGRCVTSCPPAYYADKKRKECMRCPVGCLTCTSG-FCLSCESNWEL-NKKGKCMPVGSDKCSAGEFAVDQKCKRCNPACDSCYGENEGHCLTCPNPNLLQDYKCVPECSKGYYAEA--GRCARCMHGCSDCVSRLNCTSCVSALRL--QSGAC----RTSCADGYYADR--GTCSKCYLSCRTCIGPRRDQCASCPEGWRLAAGEC-HPECPQG-FYQS-LGGCRHCHHYCRECDGSGPLHCKSCP-PRFMLDGGLCMECLGSQYYDATSGTCRSCDASCRTCSGPGQFSCSTC 1150 HSP 2 Score: 240.35 bits (612), Expect = 1.396e-60 Identity = 173/533 (32.46%), Postives = 235/533 (44.09%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQK-CIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS--CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCE------SSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFGLGDEALTNPSRSLFHYGSLLAILALMTLVIV 1337
L++ C++ CP N + C PCHESC TC G C C C+ CP GY D C PC C TCS C C+ + A CP ++T C CHESC TC G TQC C T+ + +CV CP Y D +EC+ CP GC TC++ C+ C++ W N+K C P + +C G F A+ C C C++C+ + + +CL+CP ++L C+ EC G Y + C C H C C S +C+ C + SG C +C + Y G C C SC C+GP ++C SC G L+ GEC EC GF C+ CH C C G C +CP L C+ C +++DA S C +C SC TCSGP C +CS PL +D N CVPCC S+ CC C P +C+ S R A + PS ++ A + L +V+V
Sbjct: 726 LDDSCVSRCPPRSYAN-QGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQQCPDGYWEDSEASVCRPCAAHCATCSERADGCTSCEHHLVLHDGT------CMASCPPSHYETEDDMCAKCHESCDTCQGPGETQCVTCHPSTYALDGRCVTSCPPAYYADKKRKECMRCPVGCLTCTSG-FCLSCESNWEL-NKKGKCMPVGSDKCSAGEF--AVDQKCKRCNPACDSCYGENEGHCLTCPNPNLLQDYKCVP-ECSKG--YYAEAGRCARCMHGCSDCVSRLNCTSC-VSALRLQSGACRTSC-ADGYYADRGTCSKCYLSCRTCIGPRRDQCASCPEGWRLAA-GECHPECPQGFYQSLGGCRHCHHYCRECDGSGPLHCKSCPPRFMLD-GGLCMECLGSQYYDATSGTCRSCDASCRTCSGPGQFSCSTCSRPLRIDRLNNQCVPCCSERGVTNSTPSSDCCHCNPDNGECINSSVAGKRRIAEWGALHTAPSAQSAPSAAVVTLAVCAAAVGLFIVVLV 1240
BLAST of endoprotease furin vs. nr
Match: gi|1167860|emb|CAA93116.1| (Endoprotease FURIN [Spodoptera frugiperda]) HSP 1 Score: 1005.36 bits (2598), Expect = 0.000e+0 Identity = 553/1178 (46.94%), Postives = 698/1178 (59.25%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGP---LPS-----EDFGDGLPGKMMDGSPEDGHNV--SPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFKT-RSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC 1156
+YH+ FA+H+P G + IA GF N G IG+L N++L H +R R T S EHH+ L EP V WFEQQ E+RR KRD L+ S + DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYDP ASTDINGNDEDPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D RLR D ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV+TS P PL +E GW +N V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D I G + + CS T E+RYLEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTL++ ++ + GI+KKW+++FYGT P+R +++ S P P+ E GD + ++ N+ + ++ + V+ G H +L + + + D C P+C+ C G T+C +C++++ + CV CP +Y + G C CH SC+TC GP + CLTC+ + L++D + C++ QCP GY + + C PC HC +C+E ++G C C+ LV + + C+ CP E C CHESC TC G TQC C T+ + +CV CP Y D +EC+ CP GC TC++ C+ C+ W N+K C P + +C G F + C C+ +C +C G C C + ++KCVP+C GY + C C GC C + C C + + + AC C +G ++ G C+ C +C TC + D C SCP+ L C ECP G FY + CRHC H C C+ C C F+ G C Y +G C +C+ SC C GP C +C
Sbjct: 24 VYHDQFAVHVPAGPHHVDDIARRHGFVNHGQIGSLKNYYLLSHHEVRKRSTEPSHEHHKKLNDEPQVRWFEQQREKRRIKRDYSPYDRASFSQLSRRLQPHRTNYRALTSSPFFPDPLFKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPNASTDINGNDEDPMPQDNGDNKHGTRCAGEVAAVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRSDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVMTSRPQPLEKEGGWIINGVKRKVSHKFGYGLMDASEMVSLAEQWVSVPPQHICKSQEINEDKQIESTFGYTLSAHMDVNGCSSTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTVSTLLFERPRDVVSSNFDDWPFLSVHFWGEHAEGRWTLQIVNAGNRHVNQA---GILKKWQLIFYGTSVDPVRLRTKRPSPVAPPFAFPTAADGYETIGDSFYNTDAFANYQNFPNLFAAGSDPEKAVARLDGHNVPSPHGENVLADSNDKRVMHD-------CDPECDSQGCYGKGPTQCIACKHYRLDDSCVSRCPPRSYANQGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQ-QCPDGYWEDSEASVCRPCAAHCATCSERADG---------------------CTSCEHHLV--LHDGTCMASCPPSH-YETEDDMCAKCHESCDTCQGPGETQCVTCHPSTYALDGRCVTSCPPAYYADKKRKECMRCPVGCSTCTS-AFCLSCEPKWEL-NKKGKCMPVGSDKCSAGEFAVDQKCKRCNPACDSCYGENEGHCLTCPNPNLLQDYKCVPECSKGYYAEA--GRCARCMHGCSDCVSRLNCTSCAS--TLRLQSGAC----RTSCADGYYADR--GTCSKCYLSCRTCIGPRRDQCASCPEGWRLAAGEC-HPECPQG-FYQSP-GGCRHCHHYCRECDGSGPLHCKSCP-PRFMLDGGLCMECLGSQYYDATSGTCRSCDASCRTCSGPGQFSCTTC 1150 HSP 2 Score: 238.81 bits (608), Expect = 4.215e-60 Identity = 176/536 (32.84%), Postives = 237/536 (44.22%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQK-CIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS--CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCE------SSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFG---LGDEALTNPSRSLFHYGSLLAILALMTLVIV 1337
L++ C++ CP N + C PCHESC TC G C C C+ CP GY D C PC C TCS C C+ + A CP ++T C CHESC TC G TQC C T+ + +CV CP Y D +EC+ CP GC TC++ C+ C+ W N+K C P + +C G F A+ C C C++C+ + + +CL+CP ++L C+ EC G Y + C C H C C S +C+ C L SG C +C + Y G C C SC C+GP ++C SC G L+ GEC EC GF C+ CH C C G C +CP L C+ C +++DA S C +C SC TCSGP C +CS PL +D N CVPCC S+ CC C P +C+ S ++ KR +G A PS ++ A + L V+V
Sbjct: 726 LDDSCVSRCPPRSYAN-QGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQQCPDGYWEDSEASVCRPCAAHCATCSERADGCTSCEHHLVLHDGT------CMASCPPSHYETEDDMCAKCHESCDTCQGPGETQCVTCHPSTYALDGRCVTSCPPAYYADKKRKECMRCPVGCSTCTS-AFCLSCEPKWEL-NKKGKCMPVGSDKCSAGEF--AVDQKCKRCNPACDSCYGENEGHCLTCPNPNLLQDYKCVP-ECSKG--YYAEAGRCARCMHGCSDCVSRLNCTSCASTLRLQ-SGACRTSC-ADGYYADRGTCSKCYLSCRTCIGPRRDQCASCPEGWRLAA-GECHPECPQGFYQSPGGCRHCHHYCRECDGSGPLHCKSCPPRFMLD-GGLCMECLGSQYYDATSGTCRSCDASCRTCSGPGQFSCTTCSRPLRIDRLNNQCVPCCSERGVTNSTPPTDCCHCNPENGECINSS---VAGKRRIAEWGALHTAPSADAAPSVAVVTIAVCAAAVGLFITVLV 1240
BLAST of endoprotease furin vs. nr
Match: gi|943946371|ref|XP_014356358.1| (PREDICTED: furin-like protease 2 [Papilio machaon]) HSP 1 Score: 1004.59 bits (2596), Expect = 0.000e+0 Identity = 556/1180 (47.12%), Postives = 697/1180 (59.07%), Query Frame = 0
Query: 15 GHGKIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVS--WSSGSFSTRAHS---GGILEHNKGQSGLLDYESPSS--SCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGS-FKTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTPN-GLCLACNRSCEACMGPHSNECLSC 1156
H YHN FA+H+P GE IA G+ N G IG+L ++L H + R S EHH L EP V WF+QQ ERRR KRD L+ + + DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYDP ASTDINGND+DPMPQDN DNKHGTRCAGEVA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D RLRPD ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV+TS P PL +E+GW +N V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D I + G V + + CS T E+RYLEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTL + ++ + G++KKW+++FYGT P+R + + S P F D + + +N N Q+ +++GS +A + G + G++ L D C P+C+ C G T+C +C++++ + CV CP ++ + C CH SC+TC GP + CLTC+ + L++D + C++ QCP GY + + C PC HC +C++ ++ C C+ LV + CL CP + E SC CH SC TC G TQC C ++ E +CV CP+GY D +EC+ CP GC TC + C+ C A W N+K C + +C G F +C+ CH +C +C G+ T C C +KCVP+C GY + C C GC C + C C + AC C +G ++ G CA C +C TC + D C SCP L C ECP G FY + + CR C H C C+ C C F+ G C C G++Y P+ G+CL+C+ SC C GP C C
Sbjct: 20 AHDATYHNQFAVHVPNGERHVRDIAKRHGYVNHGQIGSLKGYYLLSHHEVHKRSAEPSHEHHRKLNDEPEVRWFQQQRERRRVKRDYTQRDAGLWSQFSRRMPSHRTRHRALNPTPFFPDPLFKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPNASTDINGNDDDPMPQDNGDNKHGTRCAGEVAGVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVLTSRPQPLEKETGWIINGVKRKVSHKFGYGLMDASEMVSLAEQWVSVPPQHICKSQEINEDRSIDSSYGYTLSVHMDVNGCSATVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTTSTLLFERPRDVVSSNFDDWPFLSVHFWGERAEGRWTLHIVNAGNRHVNQ---PGVLKKWQLIFYGTSVEPVRLKGKRPSAIAP----PFAFPTAADGYDSAGDSFYNTDAFANYQNFPSLFAAGSDPEKAIAQLDGHNVPSPHGENVLADSNDKRVMHECDPECDTQGCYGKGPTQCIACKHYRLDDACVSRCPPRSFANQGAVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQ-QCPDGYWEDSESSVCRPCAAHCSTCSDKADS---------------------CTSCEHHLV--LHNGTCLASCPPSY-FETEDYSCAKCHSSCDTCEGPAETQCVTCHPSSYSLEGRCVNACPSGYYADKKRKECMKCPVGCSTCIS-TFCMSCDANWEL-NKKGKCIQTGSDKCSSGEYFDGANCNRCHTACDSCYGDEDTNCLTCPSPNLLENYKCVPECSRGYYSE--SGRCTRCVHGCSACVSRLNCTACAGALRL--QSGAC----RTSCADGYYADR--GTCAKCYLSCRTCIGPRRDQCASCPSGWRLAAGEC-HPECPQG-FYQS-VGGCRRCHHYCRECDGSGPLHCRSCP-PRFMLDGGLC-MECLGSQYYEPSTGVCLSCDNSCRTCSGPGRFSCSGC 1150 HSP 2 Score: 219.164 bits (557), Expect = 6.016e-54 Identity = 156/450 (34.67%), Postives = 206/450 (45.78%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR--SCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCF-DKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLD 1260
L++ C++ CP S + C PCHESC TC G C C C+ CP GY D C PC C TCS+ C C+ N A CP F+T SC CH SC TC G TQC C ++ E +CV CP+GY D +EC+ CP GC TC + C+ C A W N+K C + +C G + G C C + C++C+ D+ NCL+CP ++L+ C+ EC G Y ++ C C H C C S +C+ C L SG C +C + Y G C C SC C+GP ++C SC G L+ GEC EC GF C+ CH C C G C +CP L C+ C ++++ + CL+C SC TCSGP C CS PL LD
Sbjct: 726 LDDACVSRCP-PRSFANQGAVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQQCPDGYWEDSESSVCRPCAAHCSTCSDKADSCTSCEHHLVLHNGT------CLASCPPSYFETEDYSCAKCHSSCDTCEGPAETQCVTCHPSSYSLEGRCVNACPSGYYADKKRKECMKCPVGCSTCIS-TFCMSCDANWEL-NKKGKCIQTGSDKCSSGEYFD--GANCNRCHTACDSCYGDEDTNCLTCPSPNLLENYKCVP-ECSRG--YYSESGRCTRCVHGCSACVSRLNCTACAGALRLQ-SGACRTSC-ADGYYADRGTCAKCYLSCRTCIGPRRDQCASCPSGWRLAA-GECHPECPQGFYQSVGGCRRCHHYCRECDGSGPLHCRSCPPRFMLD-GGLCMECLGSQYYEPSTGVCLSCDNSCRTCSGPGRFSCSGCSRPLRLD 1157 HSP 3 Score: 119.783 bits (299), Expect = 2.665e-23 Identity = 85/258 (32.95%), Postives = 133/258 (51.55%), Query Frame = 0
Query: 1024 AQCPEGSFSKALGGLCAPCGSTCNTCFDKA-DNCLSCPKNHVL--DLSSCLDHECPNGTFYDTQLNECRHCPHNCMTC-ESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFV--DKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCL-----SCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC 1270
++CP SF+ G +C PC +C TC D+CL+C H+L DL+ CL +CP+G + D++ + CR C +C TC + SC+ C H + +G C A+C + ++T + C C+ SC+ C GP +C++C Y S G C+ C G+ K +C C C C S F C +C + +L + C+ C ++ D + C CH +C +C G +D +CL+C P +L+ N CVP C
Sbjct: 732 SRCPPRSFANQ-GAVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCL-QQCPDGYWEDSESSVCRPCAAHCSTCSDKADSCTSCE-HHLVLHNGTCLASCPPSYFETEDYSCAKCHSSCDTCEGPAETQCVTCHPSSY-SLEGRCVNACPSGYYADKKRKECMKCPVGCSTCI--STF-CMSCDANWELNKKGKCIQTGSDKCSSGEYFDGAN--CNRCHTACDSCYGDEDTNCLTCPSPNLLE--NYKCVPEC 978
BLAST of endoprotease furin vs. nr
Match: gi|1247045798|gb|PCG80179.1| (hypothetical protein B5V51_10545 [Heliothis virescens]) HSP 1 Score: 1003.05 bits (2592), Expect = 0.000e+0 Identity = 554/1178 (47.03%), Postives = 695/1178 (59.00%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGP---LPS-----EDFGDGLPGKMMDGSPEDGHNV--SPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSF-KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC 1156
+YH+ FA+H+P G + IA GF N G IG+L N++L H +R R S EHH+ L EP V WFEQQ E+RR KRD LS S + DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYDP ASTDINGND+DPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D RLR D ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV+TS P PL +E GW +N V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D I G + + CS T E+RYLEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTL++ ++ + GI+KKW+++FYGT P+R +++ S P P+ E GD + ++ N+ + ++ + V+ G H +L + + + D C P+C+ C G +C +C++++ + CV CP +Y + G C CH SC+TC GP + CLTC+ + L++D + C++ QCP GY + + C PC HC +C+E ++G C C+ LV + + CL CP E C CHESC +C G QC C T+ + KCV CP Y D +EC+ CP GC TC++ C+ C++ W N+K C P +C G F + + C C+ +C +C G C C + E+KCV +C GY P+ C C GC C + C C + + AC C +G ++ G C+ C +C TC + D C SCP L C ECP G FY + L CRHC H C C+ C C F+ G C Y +G C AC+ SC C GP C +C
Sbjct: 24 VYHDQFAVHVPAGPHHVDDIARRHGFVNHGQIGSLKNYYLLSHHEVRKRSAEPSHEHHKKLNDEPQVRWFEQQREKRRIKRDYSPYDRAAFSQLSRRLQPHRPHYRALSSSPFFPDPLFKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPNASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRSDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVMTSRPQPLEKEGGWIINGVKRKVSHKFGYGLMDASEMVSLAEQWISVPPQHICKSQEINEDKSIESTFGYTLATHMDVNGCSSTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTVSTLLFERPRDVVSSNFDDWPFLSVHFWGEHAEGRWTLQIVNAGNRHVNQA---GILKKWQLIFYGTAIDPVRLRTKRPSPVAPPFAFPTAADGYETIGDSFYNTDAFANYQNFPNLFAAGSDPEKAVARLDGHNVPSPHGENVLADSNDKRVMHD-------CDPECDSQGCYGKGPIQCIACKHYRLDDSCVSRCPPRSYANQGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQ-QCPDGYWEDSEASVCRPCAAHCATCSERADG---------------------CTSCEHHLV--LHDGTCLASCPSSH-YETEDYMCAKCHESCDSCQGPGEAQCVTCHPSTYALDGKCVTSCPPAYYADKKRKECMRCPVGCLTCTS-AFCLSCESNWEL-NKKGKCLPVGTEKCNSGEFAEDQKCKRCNGACDSCYGENDGHCLTCQNPNLLEEYKCVSECSRGYYPEA--GRCARCMHGCSECVSRLNCTACVSALRL--QSGAC----RTACADGYYADR--GTCSKCYLSCRTCIGPRRDQCASCPDGWRLAAGEC-HPECPQG-FYQS-LGGCRHCHHYCRECDGSGPLHCKSCP-PRFMLDGGLCMECLGSQYYDASSGTCRACDGSCRTCSGPGQFSCTTC 1150 HSP 2 Score: 232.261 bits (591), Expect = 5.203e-58 Identity = 171/520 (32.88%), Postives = 232/520 (44.62%), Query Frame = 0
Query: 799 GETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQK-CIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS--CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCC------ESSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFG 1306
G+ + C+ C+ L++ C++ CP N + C PCHESC TC G C C C+ CP GY D C PC C TCS C C+ + A CP ++T C CHESC +C G QC C T+ + KCV CP Y D +EC+ CP GC TC++ C+ C++ W N+K C P +C G F++ C C C++C+ + D +CL+C ++L+ C+ EC G Y + C C H C C S +C+ C + SG C C + Y G C C SC C+GP ++C SC G L+ GEC EC GF C+ CH C C G C +CP L C+ C +++DA S C AC SC TCSGP C +CS PL LD N CVPCC S+ CC+C P +C+ S ++ KR +G
Sbjct: 712 GKGPIQCIACK----HYRLDDSCVSRCPPRSYAN-QGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQQCPDGYWEDSEASVCRPCAAHCATCSERADGCTSCEHHLVLHDGT------CLASCPSSHYETEDYMCAKCHESCDSCQGPGEAQCVTCHPSTYALDGKCVTSCPPAYYADKKRKECMRCPVGCLTCTS-AFCLSCESNWEL-NKKGKCLPVGTEKCNSGEFAEDQK--CKRCNGACDSCYGENDGHCLTCQNPNLLEEYKCVS-ECSRG--YYPEAGRCARCMHGCSECVSRLNCTAC-VSALRLQSGACRTAC-ADGYYADRGTCSKCYLSCRTCIGPRRDQCASCPDGWRLAA-GECHPECPQGFYQSLGGCRHCHHYCRECDGSGPLHCKSCPPRFMLD-GGLCMECLGSQYYDASSGTCRACDGSCRTCSGPGQFSCTTCSRPLRLDRLNNQCVPCCSERGATNSTPATDCCNCNPDTGECINSS---VAGKRRIAEWG 1206
BLAST of endoprotease furin vs. nr
Match: gi|1199375267|ref|XP_021181870.1| (furin-like protease 2 [Helicoverpa armigera]) HSP 1 Score: 1001.5 bits (2588), Expect = 0.000e+0 Identity = 553/1178 (46.94%), Postives = 695/1178 (59.00%), Query Frame = 0
Query: 19 IYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGP---LPS-----EDFGDGLPGKMMDGSPEDGHNV--SPNNNGQHVSWSSGSFSTRAHSGGILEHNKGQSGLLDYESPSSSCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSF-KTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSC 1156
+YH+ FA+H+P G + IA GF N G IG+L +++L H +R R S EHH+ L EP V WFEQQ E+RR KRD L+ S + DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYD ASTDINGND+DPMPQDN DNKHGTRCAGEVAA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D RLR D ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV+TS P PL +E GW +N V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D PI G + + CS T E+RYLEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTL++ ++ + GI+KKW+++FYGT P+R +++ S P P+ E GD + ++ N+ + ++ + V+ G H +L + + + D C P+C+ C G +C +C++++ + CV CP +Y + G C CH SC+TC GP + CLTC+ + L++D + C++ QCP GY + + C PC HC +C+E ++G C C+ LV + + CL CP E C CHESC +C G QC C T+ + KCV CP Y D +EC+ CP GC TC++ C+ C+ W N+K C P +C G F + + C C+E+C +C G C C + E+KCV +C GY P+ C C GC C + C C + + AC C +G ++ G C+ C +C TC + D C SCP L C ECP G FY + L CRHC H C C+ C C F+ G C Y +G C AC+ SC C GP C +C
Sbjct: 24 VYHDQFAVHVPAGPHHVDDIARRHGFVNHGQIGSLKHYYLLSHHEVRKRSAEPSHEHHKKLNDEPQVRWFEQQREKRRTKRDYSPYDRAAFSQLSRRLQPHRPHYRALTSSPFFPDPLFKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDANASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRSDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVMTSRPQPLEKEGGWIINGVKRKVSHKFGYGLMDASEMVSLAEQWISVPPQHICKSQEINEDKPIESTFGYTLATHMDVNGCSSTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTVSTLLFERPRDVVSSNFDDWPFLSVHFWGEHAEGRWTLQIVNAGNRHVNQA---GILKKWQLIFYGTAIDPVRLRTKRPSPIAPPFAFPTAADGYETIGDSFYNTDAFANYQNFPNLFAAGSDPEKAVARLDGHNVPSPHGENVLADSNDKRVMHD-------CDPECDSQGCYGKGPIQCIACKHYRLDDSCVSRCPPRSYANQGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQ-QCPDGYWEDSESSVCRPCAAHCATCSERADG---------------------CTSCEHHLV--LHDGTCLASCPPSH-YETEDYMCAKCHESCDSCQGPGEAQCVTCHPSTYALDGKCVTSCPPAYYADKKRKECMRCPVGCSTCTS-AFCLSCEPNWEL-NKKGKCMPVGTEKCSSGEFAEAQKCKRCNEACDSCYGENDGHCLTCQNPNLLEEYKCVSECSRGYYPEA--GRCARCMHGCSECVSRLNCTACVSALRL--QSGAC----RTACADGYYADR--GTCSKCYLSCRTCIGPRRDQCASCPDGWRLAAGEC-HPECPQG-FYQS-LGGCRHCHHYCRECDGSGPLHCKSCP-PRFMLDGGLCMECLGSQYYDASSGTCRACDGSCRTCSGPGQFSCTTC 1150 HSP 2 Score: 234.958 bits (598), Expect = 7.319e-59 Identity = 172/520 (33.08%), Postives = 232/520 (44.62%), Query Frame = 0
Query: 799 GETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQK-CIKCQAGWSFANEKEACSPQANAQCPEGSFKTRS--CDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFDKAD-NCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCE------SSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFG 1306
G+ + C+ C+ L++ C++ CP N + C PCHESC TC G C C C+ CP GY D C PC C TCS C C+ + A CP ++T C CHESC +C G QC C T+ + KCV CP Y D +EC+ CP GC TC++ C+ C+ W N+K C P +C G F++A C C C++C+ + D +CL+C ++L+ C+ EC G Y + C C H C C S +C+ C + SG C C + Y G C C SC C+GP ++C SC G L+ GEC EC GF C+ CH C C G C +CP L C+ C +++DA S C AC SC TCSGP C +CS PL LD N CVPCC S+ CC+C P +C+ S ++ KR +G
Sbjct: 712 GKGPIQCIACK----HYRLDDSCVSRCPPRSYAN-QGGVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQQCPDGYWEDSESSVCRPCAAHCATCSERADGCTSCEHHLVLHDGT------CLASCPPSHYETEDYMCAKCHESCDSCQGPGEAQCVTCHPSTYALDGKCVTSCPPAYYADKKRKECMRCPVGCSTCTS-AFCLSCEPNWEL-NKKGKCMPVGTEKCSSGEFAEAQK--CKRCNEACDSCYGENDGHCLTCQNPNLLEEYKCVS-ECSRG--YYPEAGRCARCMHGCSECVSRLNCTAC-VSALRLQSGACRTAC-ADGYYADRGTCSKCYLSCRTCIGPRRDQCASCPDGWRLAA-GECHPECPQGFYQSLGGCRHCHHYCRECDGSGPLHCKSCPPRFMLD-GGLCMECLGSQYYDASSGTCRACDGSCRTCSGPGQFSCTTCSRPLRLDRLNNQCVPCCSERGATNSTPASDCCNCNPDTGECINSS---VAGKRRIAEWG 1206
BLAST of endoprotease furin vs. nr
Match: gi|910332957|ref|XP_013169849.1| (PREDICTED: furin-like protease 2 [Papilio xuthus] >gi|910332959|ref|XP_013169850.1| PREDICTED: furin-like protease 2 [Papilio xuthus]) HSP 1 Score: 996.497 bits (2575), Expect = 0.000e+0 Identity = 561/1211 (46.33%), Postives = 706/1211 (58.30%), Query Frame = 0
Query: 15 GHGKIYHNHFALHIPEGEAKANRIALNLGFKNRGPIGTLSNHFLFEHEFLRPRCTNHSLEHHEILIKEPGVHWFEQQHERRRFKRD-------------------------LSDSMYISDPLFKDQWFLNHGAFDGSDMNVQPAWAKGYTGKRVVVTILDDGIQTDHPDLRRNYDPLASTDINGNDEDPMPQDNSDNKHGTRCAGEVAAEAFNGICGVGIAYNASIGGVRMLDGLVNDAVEARALSLNPNHIDIYSASWGPEDDGKTVDGPGPLAKKAFINGVKFGRDGKGSIFVWASGNGGRKVDNCNCDGYTNSIFTLSISSASQGGKKPWYLEECSSTLASTYSSGTPGHDASIATVDQDARLRPDKICTTSHTGTSASAPIAAGVCALALEANPNLTWRDMQHIVVITSNPAPLLRESGWRVNAVGRKYSHKFGYGLMDASAMVEVAKVWPGSGRQAICETDTLSLDLPIPVNSGSVARVTLKTDACSGTKKEIRYLEHVQCKISLHYHPRGALHIVLTSPSGTKSSLLLPRPRDMTNGGFEDWPFLSVHFWGEPANGTWTLEVNHSPSVKSTSGLAKGIVKKWKMLFYGTRKSPLR-QSQLVSEFGPLPSEDFGDGLPGKMMDGSPEDGHNVSPNNNGQHVS--WSSGSFSTRAHS---GGILEHNKGQSGLLDYESPSS--SCHPQCEGNRCSGPKSTECYSCQNFKFGNVCVEHCPLTTYVSLRGTCQACHSSCQTCSGPNPNQCLTCSKSLFLLSDQSRCIKDQCPSGYRQRPSLNECVPCPYHCESCTETSEGVVNLIEGPRSGSLGIGETTLVCLKCQKGLVRSVLENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGS-FKTRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCFD-KADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSS--CSQCGLDHFLTGSGKCSANCQGNEYQTP-NGLCLACNRSCEACMGPHSNECLSC-RVGKYLSTTGECLEECLHGFVDKNSQCQAC 1186
H YHN FA+H+P GE + IA G+ N G IG+L ++L H + R S EHH L EP V WF+QQ ERRR KRD L+ + + DPLFK+QW+LN GA DG DMNV PAW KGYTGK VVV+ILDDGIQT+HPDL +NYD ASTDINGND+DPMPQDN DNKHGTRCAGEVA A+N CGVGIAYNASIGGVRMLDG+VNDAVEARAL LNP+HIDIYSASWGPEDDGKTVDGPGPLA++AFI GV GR GKGSIFVWASGNGGR D+CNCDGYTNSIFTLSISSA+QGG KPWYLEECSSTLA+TYSSGTPGHD S+ATVD D RLRPD ICT HTGTSASAP+AAG+CALALEANP LTWRDMQ++VV+TS P PL +E+GW +N V RK SHKFGYGLMDAS MV +A+ W Q IC++ ++ D I + G V + + CS T E+RYLEHVQCKISL + PRG L I+LTSP GT S+LL RPRD+ + F+DWPFLSVHFWGE A G WTL + ++ + G++KKW+++FYGT P+R + + S P F D + + +N N Q+ +++GS +A + G + G++ L D C P+C+ C G T+C +C++++ + CV CP ++ + C CH SC+TC GP + CLTC+ + L++D + C++ QCP GY + + C PC HC +C++ ++ C C+ LV + CL CP + E SC CH SC TC G TQC C +F E +CV CP+GY D +EC+ CP GC TC + C+ C A W N+K C + +C G F SC+ C+ +C +C G+ T C C +KCV +C GY + C C GC C + C C + AC C +G ++ G CA C +C TC + D C SCP L C ECP G FY + + CR C H C C+ C C F+ G C C G++Y P +G+CL+C+ +C C GP C C R + +C+ C V NS C
Sbjct: 23 AHDATYHNQFAVHVPNGERHVHDIAKRHGYVNHGQIGSLKGYYLLSHHEVHKRSAEPSHEHHRKLNDEPEVRWFQQQRERRRVKRDYTQRDAGLWSQFSRRMPSHRTRHRALNPTPFFPDPLFKEQWYLNGGAKDGLDMNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDANASTDINGNDDDPMPQDNGDNKHGTRCAGEVAGVAYNQYCGVGIAYNASIGGVRMLDGVVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVLTSRPQPLEKETGWIINGVKRKVSHKFGYGLMDASEMVSLAEQWVSVPPQHICKSQEINEDKSIDSSYGYTLSVHMDVNGCSATVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTTSTLLFERPRDVVSSNFDDWPFLSVHFWGERAEGRWTLHIVNAGNRHVNQ---PGVLKKWQLIFYGTSVEPVRLRGKKPSAIAP----PFAFPTAADGYDSAGDSFYNTDAFANYQNFPSLFAAGSDPEKAIAQLDGHNVPSPHGENVLADSNDKRVMHECDPECDTQGCYGKGPTQCIACKHYRLDDACVSRCPPRSFANQGAVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQ-QCPDGYWEDSESSVCRPCAAHCSTCSDKADS---------------------CTSCEHHLV--LHNGTCLASCPPSY-FETEDYSCAKCHSSCDTCEGPAETQCVTCHPSSFSLEGRCVNACPSGYYADKKRKECMKCPVGCSTCIS-AFCMSCDANWEL-NKKGKCIQTGSDKCSSGEYFDGASCNRCNNACDSCYGDEDTNCLTCPAPNLLENYKCVAECSRGYFSE--SGRCTRCVHGCAACVSRLNCTACAGALRL--QSGAC----RTSCADGYYADR--GTCAKCYLSCRTCIGPRRDQCASCPSGWRLAAGEC-HPECPQG-FYQS-VGGCRRCHHYCRECDGSGPLHCLSCP-PRFMLDGGLC-MECLGSQYYEPSSGVCLSCDNTCRTCSGPGRFSCSGCSRPLRLDRLNNQCVPCCSERGVYANSSASDC 1184 HSP 2 Score: 236.884 bits (603), Expect = 1.808e-59 Identity = 172/502 (34.26%), Postives = 227/502 (45.22%), Query Frame = 0
Query: 817 LENKCLNGCPFGFSLNPETRSCDPCHESCATCTGNLSTQCSLCLDGTFYFEH--KCVPDCPAGYRPDVHHQECVPCPQGCHTCSND-QKCIKCQAGWSFANEKEACSPQANAQCPEGSFKTR--SCDPCHESCATCTGNLSTQCSLCLDGTFYFEHKCVPDCPAGYRPDVHHQECVPCPQGCHTCSNDQKCIKCQAGWSFANEKEACSPQANAQCPEGSFSKALGGLCAPCGSTCNTCF-DKADNCLSCPKNHVLDLSSCLDHECPNGTFYDTQLNECRHCPHNCMTCESVSSCSQCGLDHFLTGSGKCSANCQGNEYQTPNGLCLACNRSCEACMGPHSNECLSCRVGKYLSTTGECLEECLHGFVDKNSQCQACHSSCLACTGPSLFQCSTCPSGTKLGPQANCLSCEPRKFHDAHSDECLACHESCGTCSGPQDNHCLSCSLPLVLDTWNTTCVPCCE------SSDEKHCCSCTPSRDKCLQPSKKMLSRKRSSVRFG 1306
L++ C++ CP S + C PCHESC TC G C C C+ CP GY D C PC C TCS+ C C+ N A CP F+T SC CH SC TC G TQC C +F E +CV CP+GY D +EC+ CP GC TC + C+ C A W N+K C + +C G + G C C + C++C+ D+ NCL+CP ++L+ C+ EC G F ++ C C H C C S +C+ C L SG C +C + Y G C C SC C+GP ++C SC G L+ GEC EC GF C+ CH C C G C +CP L C+ C ++++ S CL+C +C TCSGP C CS PL LD N CVPCC +S CC C +C+ S ++ KR +G
Sbjct: 729 LDDACVSRCP-PRSFANQGAVCWPCHESCETCVGPGQDSCLTCAPAHLLVADLAVCLQQCPDGYWEDSESSVCRPCAAHCSTCSDKADSCTSCEHHLVLHNGT------CLASCPPSYFETEDYSCAKCHSSCDTCEGPAETQCVTCHPSSFSLEGRCVNACPSGYYADKKRKECMKCPVGCSTCIS-AFCMSCDANWEL-NKKGKCIQTGSDKCSSGEYFD--GASCNRCNNACDSCYGDEDTNCLTCPAPNLLENYKCVA-ECSRGYF--SESGRCTRCVHGCAACVSRLNCTACAGALRLQ-SGACRTSC-ADGYYADRGTCAKCYLSCRTCIGPRRDQCASCPSGWRLAA-GECHPECPQGFYQSVGGCRRCHHYCRECDGSGPLHCLSCPPRFMLD-GGLCMECLGSQYYEPSSGVCLSCDNTCRTCSGPGRFSCSGCSRPLRLDRLNNQCVPCCSERGVYANSSASDCCHCNMDTGECINSS---VAGKRRIAEWG 1209 The following BLAST results are available for this feature:
BLAST of endoprotease furin vs. L. salmonis genes
Analysis Date: 2018-04-19 (T. kinsejongensis vs L. Salmonis peptides) Total hits: 9
BLAST of endoprotease furin vs. SwissProt
Analysis Date: 2018-04-19 (T. kingejongensis peptided Blastp vs. SwissProt) Total hits: 25
Pagesback to top
BLAST of endoprotease furin vs. nr
Analysis Date: 2018-05-15 (T. kingsejongensis proteins Blastp vs. NR) Total hits: 25
Pagesback to topAlignments
The following features are aligned
Analyses
This gene is derived from or has results from the following analyses
Properties
Relationships
The following mRNA feature(s) are a part of this gene:
Sequences
The following sequences are available for this feature:
gene from alignment at scaffold298_size217389:6483..10828+ Legend: mRNA Hold the cursor over a type above to highlight its positions in the sequence below.>snap_masked-scaffold298_size217389-processed-gene-0.1 ID=snap_masked-scaffold298_size217389-processed-gene-0.1|Name=endoprotease furin|organism=Tigriopus kingsejongensis|type=gene|length=4346bp|location=Sequence derived from alignment at scaffold298_size217389:6483..10828+ (Tigriopus kingsejongensis)back to top Synonyms
The feature 'endoprotease furin' has the following synonyms
Add to Basket
|