Signatures of resistance to Lepeophtheirus salmonis include a TH2-type response at the louse-salmon interface

Overview
TitleSignatures of resistance to Lepeophtheirus salmonis include a TH2-type response at the louse-salmon interface
AuthorsBraden LM, Koop BF, Jones SR
TypeJournal Article
Journal NameDevelopmental and comparative immunology
Volume48
Issue1
Year2015
Page(s)178-91
CitationBraden LM, Koop BF, Jones SR. Signatures of resistance to Lepeophtheirus salmonis include a TH2-type response at the louse-salmon interface. Developmental and comparative immunology. 2015 Jan; 48(1):178-91.

Abstract

Disease outbreaks with the salmon louse Lepeophtheirus salmonis cause significant economic losses in mariculture operations worldwide. Variable innate immune responses at the louse-attachment site contribute to differences in susceptibility among species such that members of Salmo spp. are more susceptible to infection than those of some Oncorhynchus spp. Relatively little is known about the mechanisms that contribute to disease resistance or susceptibility to L. salmonis in salmon. Here, we utilize histochemistry and transcriptomics in a comparative infection model with susceptible (Atlantic, sockeye) and resistant (coho) salmon. At least three cell populations (MHIIβ+, IL1β+, TNFα+) were activated in coho salmon skin during L. salmonis infection. Locally elevated expression of several pro-inflammatory mediators (e.g. IL1β, IL8, TNFα, COX2, C/EBPβ), and tissue repair enzymes (MMP9, MMP13) were detected in susceptible and resistant species. However, responses specific to coho salmon (e.g. IL4, IL6, TGFβ) or responses shared among susceptible salmon (e.g. SAP, TRF, Cath in Atlantic and sockeye salmon) provide evidence for species-specific pathways contributing to resistance or susceptibility, respectively. Our results confirm the importance of an early pro-inflammatory TH1-type pathway as an initial host response during infection with Pacific sea lice, and demonstrate subsequent regulatory TH2-type processes as candidate defense mechanisms in the skin of resistant coho salmon.

Author Details
Additional information about authors:
Details
1Laura M Braden
2Ben F Koop
3Simon R M Jones
Properties
Additional details for this publication include:
Property NameValue
Publication ModelPrint-Electronic
ISSN1879-0089
eISSN1879-0089
Publication Date2015 Jan
Journal AbbreviationDev. Comp. Immunol.
DOI10.1016/j.dci.2014.09.015
ElocationS0145-305X(14)00250-X
PIIS0145-305X(14)00250-X
CopyrightCrown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.
LanguageEnglish
Language Abbreng
Publication TypeJournal Article
Journal CountryUnited States
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PMID: PMID:25453579