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The key to sustainable sea lice control is in the genome.

Parasitism perturbs the mucosal microbiome of Atlantic Salmon

Overview
TitleParasitism perturbs the mucosal microbiome of Atlantic Salmon
AuthorsLlewellyn MS, Leadbeater S, Garcia C, Sylvain FE, Custodio M, Ang KP, Powell F, Carvalho GR, Creer S, Elliot J, Derome N
TypeJournal Article
Journal NameScientific reports
Volume7
IssueN/A
Year2017
Page(s)43465
CitationLlewellyn MS, Leadbeater S, Garcia C, Sylvain FE, Custodio M, Ang KP, Powell F, Carvalho GR, Creer S, Elliot J, Derome N. Parasitism perturbs the mucosal microbiome of Atlantic Salmon. Scientific reports. 2017 Mar 07; 7:43465.

Abstract

<p>Interactions between parasite, host and host-associated microbiota are increasingly understood as important determinants of disease progression and morbidity. Salmon lice, including the parasitic copepod Lepeophtheirus salmonis and related species, are perhaps the most important problem facing Atlantic Salmon aquaculture after feed sustainability. Salmon lice parasitize the surface of the fish, feeding off mucus, scales and underlying tissue. Secondary bacterial infections are a major source of associated morbidity. In this study we tracked the diversity and composition of Salmo salar skin surface microbiota throughout a complete L. salmonis infection cycle among 800 post-smolts as compared to healthy controls. Among infected fish we observed a significant reduction in microbial richness (Chao1, P = 0.0136), raised diversity (Shannon, P < 7.86e-06) as well as highly significant destabilisation of microbial community composition (Pairwise Unifrac, beta-diversity, P < 1.86e-05; P = 0.0132) by comparison to controls. While undetectable on an individual level, network analysis of microbial taxa on infected fish revealed the association of multiple pathogenic genera (Vibrio, Flavobacterium, Tenacibaculum, Pseudomonas) with high louse burdens. We discuss our findings in the context of ecological theory and colonisation resistance, in addition to the role microbiota in driving primary and secondary pathology in the host.</p>
Author Details
Additional information about authors:
Details
1M S Llewellyn
2S Leadbeater
3C Garcia
4F-E Sylvain
5M Custodio
6K P Ang
7F Powell
8G R Carvalho
9S Creer
10J Elliot
11N Derome
Properties
Additional details for this publication include:
Property NameValue
Journal CountryEngland
Publication TypeJournal Article
Language Abbreng
LanguageEnglish
Elocation10.1038/srep43465
DOI10.1038/srep43465
Journal AbbreviationSci Rep
Publication Date2017 Mar 07
eISSN2045-2322
ISSN2045-2322
Publication ModelElectronic
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DatabaseAccession
PMID: PubMedPMID:28266549