Salmon immunological defense and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis

Overview
TitleSalmon immunological defense and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis
AuthorsBraden LM, Monaghan SJ, Fast MD
TypeJournal Article
Journal NameParasite immunology
VolumeN/A
IssueN/A
Year2020
Page(s)N/A
CitationBraden LM, Monaghan SJ, Fast MD. Salmon immunological defense and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis. Parasite immunology. 2020 May 13.

Abstract

The salmon louse Lepeophtheirus salmonis (Lsal) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host-parasite relationship has provided a plethora of information on the intricacies of host resistance and parasite adaptation. Atlantic salmon exhibit temporal and spatial impairment of the immune system and wound healing ability during infection. This immunosuppression may render Atlantic salmon less tolerant to stress and other confounders associated with current management strategies. Contrasting susceptibility of salmonid hosts exists and early pro-inflammatory Th1 type responses are associated with resistance. Rapid cellular responses to larvae appear to tip the balance of the host-parasite relationship in favour of the host, preventing severe immune-physiological impacts of the more invasive adults. Immunological, transcriptomic, genomic and proteomic evidence suggests pathological impacts occur in susceptible hosts through modulation of host immunity and physiology via pharmacologically active molecules. Co-evolutionary and farming selection pressures may have incurred preference of Atlantic salmon as a host for Lsal reflected in their interactome. Here we review host-parasite interactions at the primary attachment/feeding site, and the complex life-stage dependent molecular mechanisms employed to subvert host physiology and immune responses.

Author Details
Additional information about authors:
Details
1Laura M Braden
2Sean J Monaghan
3Mark D Fast
Properties
Additional details for this publication include:
Property NameValue
Journal CountryEngland
Publication TypeJournal Article
Language Abbreng
LanguageEnglish
CopyrightThis article is protected by copyright. All rights reserved.
Elocation10.1111/pim.12731
DOI10.1111/pim.12731
Journal AbbreviationParasite Immunol.
Publication Date2020 May 13
eISSN1365-3024
ISSN1365-3024
Publication ModelPrint-Electronic
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PMID: PMID:32403169