Transcriptome profiling of the early developmental stages in the giant mussel Choromytilus chorus exposed to delousing drugs

Overview
TitleTranscriptome profiling of the early developmental stages in the giant mussel Choromytilus chorus exposed to delousing drugs
AuthorsNúñez-Acuña G, Fernandez C, Sanhueza-Guevara S, Gallardo-Escárate C
TypeJournal Article
Journal NameMarine genomics
Volume65
IssueN/A
Year2022
Page(s)100970
CitationNúñez-Acuña G, Fernandez C, Sanhueza-Guevara S, Gallardo-Escárate C. Transcriptome profiling of the early developmental stages in the giant mussel Choromytilus chorus exposed to delousing drugs. Marine genomics. 2022 Jul 12; 65:100970.

Abstract

The giant mussel Choromytilus chorus is a marine bivalve commonly collected in central - southern Chile from fishery zones shared with the salmon industry. These economically relevant areas are also affected by the use of pesticides for controlling sea lice infestations in salmon aquaculture. Their main target is the sea louse Caligus rogercresseyi. However, other than some physiological impacts, the molecular effects of delousing drugs in non-target species such as C. chorus remain largely understudied. This study aimed to explore the transcriptome modulation of Trochophore and D larvae stages of C. chorus after exposure to azamethiphos and deltamethrin drugs. Herein, RNA-seq analyses and mRNA-lncRNAs molecular interactions were obtained. The most significant changes were found between different larval development stages exposed to delousing drugs. Notably, significant transcriptional variations were correlated with the drug concentrations tested. The biological processes involved in the development, such as cell movement and transcriptional activity, were mainly affected. Long non-coding RNAs (lncRNAs) were also identified in this species, and the transcription activity showed similar patterns with coding mRNAs. Most of the significantly expressed lncRNAs were associated with genes annotated to matrix metalloproteinases, collagenases, and transcription factors. This study suggests that exposure to azamethiphos or deltamethrin drugs can modulate the transcriptome signatures related to the early development of the giant mussel C. chorus.

Properties
Additional details for this publication include:
Property NameValue
Journal CountryNetherlands
Publication TypeJournal Article
Language Abbreng
LanguageEnglish
CopyrightCopyright © 2022 Elsevier B.V. All rights reserved.
DOI10.1016/j.margen.2022.100970
Elocation10.1016/j.margen.2022.100970
PIIS1874-7787(22)00048-4
Journal AbbreviationMar Genomics
Publication Date2022 Jul 12
eISSN1876-7478
ISSN1876-7478
Publication ModelPrint-Electronic
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DatabaseAccession
PMID: PMID:35839704