Protein

## EMLSAP00000009424

Length
873 amino acids

### Protein family membership

- Hydroxymethylglutaryl-CoA lyase (IPR027167)

- Eukaryotic molybdopterin oxidoreductase (IPR008335)

### Domains and repeats

1. Domain
   29 - 317
   - Aldolase-type TIM barrel (IPR013785)
     - Pyruvate carboxyltransferase (IPR000891)
   745 - 872
   - Immunoglobulin E-set (IPR014756)
     - Moybdenum cofactor oxidoreductase, dimerisation (IPR005066)
2. Domain
   416 - 503
   - Cytochrome b5-like heme/steroid binding domain (IPR001199)
   510 - 747
   - Oxidoreductase, molybdopterin-binding domain (IPR000572)

1 100 200 300 400 500 600 700 800 873

### Detailed signature matches

1. IPR027167
   Hydroxymethylglutaryl-CoA lyase
   1. PTHR10277:SF1 (HYDR...)
      27 - 334
      PANTHER
      PTHR10277:SF1 (HYDROXYMETHYLGLUTARYL-COA LYASE)
2. IPR008335
   Eukaryotic molybdopterin oxidoreductase
   1. PR00407 (EUMOPTERIN)
      776 - 790
      PRINTS
      PR00407 (EUMOPTERIN)
      668 - 684
      PRINTS
      PR00407 (EUMOPTERIN)
      701 - 714
      PRINTS
      PR00407 (EUMOPTERIN)
      545 - 561
      PRINTS
      PR00407 (EUMOPTERIN)
      790 - 802
      PRINTS
      PR00407 (EUMOPTERIN)
      857 - 870
      PRINTS
      PR00407 (EUMOPTERIN)
      747 - 759
      PRINTS
      PR00407 (EUMOPTERIN)
      817 - 827
      PRINTS
      PR00407 (EUMOPTERIN)
      524 - 538
      PRINTS
      PR00407 (EUMOPTERIN)
      685 - 698
      PRINTS
      PR00407 (EUMOPTERIN)
      842 - 854
      PRINTS
      PR00407 (EUMOPTERIN)
3. IPR013785
   Aldolase-type TIM barrel
   1. G3DSA:3.20.20.70
      29 - 317
      GENE3D
      G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
4. IPR000891
   Pyruvate carboxyltransferase
   1. PF00682 (HMGL-like)
      38 - 288
      Pfam
      PF00682 (HMGL-like)
   2. PS50991 (PYR_CT)
      30 - 300
      PROSITE profiles
      PS50991 (PYR_CT)
5. IPR001199
   Cytochrome b5-like heme/steroid binding domain
   1. PF00173 (Cyt-b5)
      421 - 498
      Pfam
      PF00173 (Cyt-b5)
   2. G3DSA:3.10.12...
      416 - 499
      GENE3D
      G3DSA:3.10.120.10 (G3DSA:3.10.120.10)
   3. PS50255 (CYTOCHROME...)
      418 - 498
      PROSITE profiles
      PS50255 (CYTOCHROME_B5_2)
   4. SSF55856 (Cytochrom...)
      416 - 503
      SUPERFAMILY
      SSF55856 (Cytochrome b5-like heme/steroid binding domain)
6. IPR000572
   Oxidoreductase, molybdopterin-binding domain
   1. G3DSA:3.90.42...
      514 - 746
      GENE3D
      G3DSA:3.90.420.10 (G3DSA:3.90.420.10)
   2. SSF56524 (Oxidoredu...)
      510 - 747
      SUPERFAMILY
      SSF56524 (Oxidoreductase molybdopterin-binding domain)
   3. PF00174 (Oxidored_m...)
      555 - 723
      Pfam
      PF00174 (Oxidored_molyb)
7. IPR014756
   Immunoglobulin E-set
   1. SSF81296 (E set dom...)
      750 - 872
      SUPERFAMILY
      SSF81296 (E set domains)
8. IPR005066
   Moybdenum cofactor oxidoreductase, dimerisation
   1. PF03404 (Mo-co_dimer)
      745 - 872
      Pfam
      PF03404 (Mo-co_dimer)
   2. G3DSA:2.60.40...
      750 - 872
      GENE3D
      G3DSA:2.60.40.650 (G3DSA:2.60.40.650)
9. IPR000138
   Hydroxymethylglutaryl-CoA lyase, active site
   1. PS01062 (HMG_COA_LYASE)
      259 - 268
      PROSITE patterns
      PS01062 (HMG_COA_LYASE)

no IPR
Unintegrated signatures

1. PTHR10277 (HOMOCITR...)
   27 - 334
   PANTHER
   PTHR10277 (HOMOCITRATE SYNTHASE-RELATED)
2. SSF51569 (Aldolase)
   25 - 320
   SUPERFAMILY
   SSF51569 (Aldolase)

### GO term prediction

#### Biological Process

GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0003824 catalytic activity
GO:0004419 hydroxymethylglutaryl-CoA lyase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0030151 molybdenum ion binding
GO:0046872 metal ion binding

#### Cellular Component

None predicted.