Protein

## EMLSAP00000002599

Length
1,576 amino acids

### Protein family membership

- Tuberin/Ral GTPase-activating protein subunit alpha (IPR027107)
  - Tuberin (IPR003913)

### Domains and repeats

1. Domain
   49 - 478
   - Tuberin, N-terminal (IPR024584)
   559 - 850
   - Tuberin-type domain (IPR018515)
   1,313 - 1,535
   - Rap GTPase activating protein domain (IPR000331)
2. Domain
   74 - 110
   - Armadillo-type fold (IPR016024)
   158 - 236
   - Armadillo-type fold (IPR016024)
   280 - 368
   - Armadillo-type fold (IPR016024)
   445 - 543
   - Armadillo-type fold (IPR016024)
   644 - 864
   - Armadillo-type fold (IPR016024)

1 200 400 600 800 1000 1200 1400 1576

### Detailed signature matches

1. IPR027107
   Tuberin/Ral GTPase-activating protein subunit alpha
   1. PTHR10063 (TUBERIN)
      2 - 1,541
      PANTHER
      PTHR10063 (TUBERIN)
2. IPR003913
   Tuberin
   1. PTHR10063:SF1 (TUBERIN)
      2 - 1,541
      PANTHER
      PTHR10063:SF1 (TUBERIN)
   2. PR01431 (TUBERIN)
      830 - 850
      PRINTS
      PR01431 (TUBERIN)
      784 - 804
      PRINTS
      PR01431 (TUBERIN)
      213 - 232
      PRINTS
      PR01431 (TUBERIN)
3. IPR024584
   Tuberin, N-terminal
   1. PF11864 (DUF3384)
      49 - 478
      Pfam
      PF11864 (DUF3384)
4. IPR016024
   Armadillo-type fold
   1. SSF48371 (ARM repeat)
      280 - 368
      SUPERFAMILY
      SSF48371 (ARM repeat)
      158 - 236
      SUPERFAMILY
      SSF48371 (ARM repeat)
      74 - 110
      SUPERFAMILY
      SSF48371 (ARM repeat)
      445 - 543
      SUPERFAMILY
      SSF48371 (ARM repeat)
      644 - 864
      SUPERFAMILY
      SSF48371 (ARM repeat)
5. IPR018515
   Tuberin-type domain
   1. PF03542 (Tuberin)
      559 - 850
      Pfam
      PF03542 (Tuberin)
6. IPR000331
   Rap GTPase activating protein domain
   1. PS50085 (RAPGAP)
      1,313 - 1,535
      PROSITE profiles
      PS50085 (RAPGAP)
   2. PF02145 (Rap_GAP)
      1,343 - 1,478
      Pfam
      PF02145 (Rap_GAP)

no IPR
Unintegrated signatures

1. Coil
   1,521 - 1,545
   COILS
   Coil (Coil)
2. SSF111347 (Rap/Ran-GAP)
   1,284 - 1,535
   SUPERFAMILY
   SSF111347 (Rap/Ran-GAP)

### GO term prediction

#### Biological Process

GO:0032007 negative regulation of TOR signaling
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction

#### Molecular Function

GO:0005096 GTPase activator activity
GO:0005488 binding

#### Cellular Component

GO:0005634 nucleus
GO:0033596 TSC1-TSC2 complex