Protein

## EMLSAP00000007737

Length
465 amino acids

### Protein family membership

- Neurotransmitter-gated ion-channel (IPR006201)

### Domains and repeats

1. Domain
   30 - 71
   - Neurotransmitter-gated ion-channel ligand-binding (IPR006202)
   188 - 462
   - Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)
2. Domain
   71 - 124
   - Neurotransmitter-gated ion-channel ligand-binding (IPR006202)
   125 - 188
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)
   189 - 271
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)
   414 - 462
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)
3. Domain
   125 - 190
   - Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)

1 50 100 150 200 250 300 350 400 465

### Detailed signature matches

1. IPR006201
   Neurotransmitter-gated ion-channel
   1. PTHR18945 (NEUROTRA...)
      25 - 458
      PANTHER
      PTHR18945 (NEUROTRANSMITTER GATED ION CHANNEL)
2. IPR006202
   Neurotransmitter-gated ion-channel ligand-binding
   1. SSF63712 (Nicotinic...)
      80 - 124
      SUPERFAMILY
      SSF63712 (Nicotinic receptor ligand binding domain-like)
      30 - 71
      SUPERFAMILY
      SSF63712 (Nicotinic receptor ligand binding domain-like)
   2. G3DSA:2.70.17...
      71 - 124
      GENE3D
      G3DSA:2.70.170.10 (G3DSA:2.70.170.10)
      32 - 70
      GENE3D
      G3DSA:2.70.170.10 (G3DSA:2.70.170.10)
3. IPR027361
   Nicotinic acetylcholine-gated receptor, transmembrane domain
   1. G3DSA:1.20.12...
      125 - 188
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
      414 - 462
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
      189 - 271
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
4. IPR006029
   Neurotransmitter-gated ion-channel transmembrane domain
   1. SSF90112 (Neurotran...)
      125 - 189
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
      188 - 351
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
      395 - 462
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
   2. PF02932 (Neur_chan_...)
      132 - 190
      Pfam
      PF02932 (Neur_chan_memb)
      188 - 454
      Pfam
      PF02932 (Neur_chan_memb)

no IPR
Unintegrated signatures

1. PTHR18945:SF70 (NIC...)
   25 - 458
   PANTHER
   PTHR18945:SF70 (NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA)
2. SignalP-noTM
   1 - 27
   SignalP euk
   SignalP-noTM (SignalP-noTM)
3. TMhelix
   230 - 252
   TMHMM
   TMhelix (TMhelix)
   441 - 463
   TMHMM
   TMhelix (TMhelix)
   127 - 149
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006810 transport
GO:0006811 ion transport

#### Molecular Function

GO:0005230 extracellular ligand-gated ion channel activity

#### Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane