Protein

## EMLSAP00000004194

Length
1,834 amino acids

### Protein family membership

- Glutamate synthase, eukaryotic (IPR012220)

- Glutamate synthase, NADH/NADPH, small subunit 1 (IPR006005)

### Domains and repeats

1. Domain
   26 - 453
   - Glutamine amidotransferase type 2 domain (IPR017932)
   1,491 - 1,576
   - NAD(P)-binding domain (IPR016040)
   1,756 - 1,817
   - NAD(P)-binding domain (IPR016040)
2. Domain
   26 - 389
   - Class II glutamine amidotransferase domain (IPR000583)
   532 - 927
   - Aldolase-type TIM barrel (IPR013785)
     - Glutamate synthase, central-N (IPR006982)
   928 - 1,108
   - Aldolase-type TIM barrel (IPR013785)
     - Glutamate synthase, central-C (IPR002932)
   1,140 - 1,307
   - Glutamate synthase, alpha subunit, C-terminal (IPR002489)
   1,490 - 1,793
   - Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain (IPR023753)
3. Domain
   1,345 - 1,497
   - Alpha-helical ferredoxin (IPR009051)
4. Domain
   1,369 - 1,478
   - Dihydroprymidine dehydrogenase domain II (IPR028261)
   1,490 - 1,563
   - Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain (IPR001327)

1 200 400 600 800 1000 1200 1400 1600 1834

### Detailed signature matches

1. IPR012220
   Glutamate synthase, eukaryotic
   1. PIRSF000187 (GOGAT)
      1 - 1,832
      PIRSF
      PIRSF000187 (GOGAT)
2. IPR006005
   Glutamate synthase, NADH/NADPH, small subunit 1
   1. TIGR01317
      1,345 - 1,819
      UNKNOWN
      TIGR01317 (TIGR01317)
3. IPR000583
   Class II glutamine amidotransferase domain
   1. PF00310 (GATase_2)
      26 - 389
      Pfam
      PF00310 (GATase_2)
4. IPR017932
   Glutamine amidotransferase type 2 domain
   1. PS51278 (GATASE_TYPE_2)
      26 - 453
      PROSITE profiles
      PS51278 (GATASE_TYPE_2)
5. IPR013785
   Aldolase-type TIM barrel
   1. G3DSA:3.20.20.70
      758 - 927
      GENE3D
      G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
      532 - 610
      GENE3D
      G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
      678 - 757
      GENE3D
      G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
      928 - 1,108
      GENE3D
      G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
6. IPR006982
   Glutamate synthase, central-N
   1. PF04898 (Glu_syn_ce...)
      534 - 791
      Pfam
      PF04898 (Glu_syn_central)
7. IPR002932
   Glutamate synthase, central-C
   1. PF01645 (Glu_synthase)
      928 - 1,089
      Pfam
      PF01645 (Glu_synthase)
8. IPR002489
   Glutamate synthase, alpha subunit, C-terminal
   1. G3DSA:2.160.2...
      1,212 - 1,307
      GENE3D
      G3DSA:2.160.20.60 (G3DSA:2.160.20.60)
      1,148 - 1,211
      GENE3D
      G3DSA:2.160.20.60 (G3DSA:2.160.20.60)
   2. PF01493 (GXGXG)
      1,206 - 1,247
      Pfam
      PF01493 (GXGXG)
   3. SSF69336 (Alpha sub...)
      1,140 - 1,301
      SUPERFAMILY
      SSF69336 (Alpha subunit of glutamate synthase, C-terminal domain)
9. IPR009051
   Alpha-helical ferredoxin
   1. SSF46548 (alpha-hel...)
      1,345 - 1,497
      SUPERFAMILY
      SSF46548 (alpha-helical ferredoxin)
10. IPR028261
    Dihydroprymidine dehydrogenase domain II
    1. PF14691 (Fer4_20)
       1,369 - 1,478
       Pfam
       PF14691 (Fer4_20)
11. IPR001327
    Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
    1. PF00070 (Pyr_redox)
       1,490 - 1,563
       Pfam
       PF00070 (Pyr_redox)
12. IPR023753
    Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
    1. PF07992 (Pyr_redox_2)
       1,490 - 1,793
       Pfam
       PF07992 (Pyr_redox_2)
13. IPR016040
    NAD(P)-binding domain
    1. G3DSA:3.40.50...
       1,491 - 1,576
       GENE3D
       G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
       1,756 - 1,817
       GENE3D
       G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

no IPR
Unintegrated signatures

1. Coil
   386 - 390
   COILS
   Coil (Coil)
2. G3DSA:1.10.10...
   1,345 - 1,490
   GENE3D
   G3DSA:1.10.1060.10 (G3DSA:1.10.1060.10)
3. G3DSA:3.50.50.60
   1,577 - 1,752
   GENE3D
   G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
4. G3DSA:3.60.20.10
   26 - 389
   GENE3D
   G3DSA:3.60.20.10 (G3DSA:3.60.20.10)
   422 - 481
   GENE3D
   G3DSA:3.60.20.10 (G3DSA:3.60.20.10)
5. PR00419 (ADXRDTASE)
   1,626 - 1,640
   PRINTS
   PR00419 (ADXRDTASE)
   1,489 - 1,511
   PRINTS
   PR00419 (ADXRDTASE)
   1,512 - 1,525
   PRINTS
   PR00419 (ADXRDTASE)
6. PTHR11938 (FAD NADP...)
   16 - 1,316
   PANTHER
   PTHR11938 (FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE)
7. PTHR11938:SF1 (GLUT...)
   16 - 1,316
   PANTHER
   PTHR11938:SF1 (GLUTAMATE SYNTHASE)
8. SSF51395 (FMN-linke...)
   533 - 1,106
   SUPERFAMILY
   SSF51395 (FMN-linked oxidoreductases)
9. SSF51905 (FAD/NAD(P...)
   1,487 - 1,816
   SUPERFAMILY
   SSF51905 (FAD/NAD(P)-binding domain)
10. SSF56235 (N-termina...)
    26 - 384
    SUPERFAMILY
    SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))
    416 - 478
    SUPERFAMILY
    SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))

### GO term prediction

#### Biological Process

GO:0006537 glutamate biosynthetic process
GO:0006807 nitrogen compound metabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0003824 catalytic activity
GO:0005506 iron ion binding
GO:0010181 FMN binding
GO:0015930 glutamate synthase activity
GO:0016040 glutamate synthase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
GO:0045181 glutamate synthase activity, NAD(P)H as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0051536 iron-sulfur cluster binding

#### Cellular Component

None predicted.