Protein

## EMLSAP00000001573

Length
1,310 amino acids

### Protein family membership

- DNA helicase, ATP-dependent, RecQ type (IPR004589)

### Domains and repeats

1. Domain
   548 - 718
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   761 - 1,023
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
2. Domain
   569 - 770
   - Helicase, superfamily 1/2, ATP-binding domain (IPR014001)
     - DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545)
   778 - 927
   - Helicase, C-terminal (IPR001650)
   977 - 1,093
   - RQC domain (IPR018982)
3. Domain
   901 - 1,094
   - Winged helix-turn-helix DNA-binding domain (IPR011991)

1 200 400 600 800 1000 1200 1310

### Detailed signature matches

1. IPR004589
   DNA helicase, ATP-dependent, RecQ type
   1. TIGR00614
      564 - 1,035
      UNKNOWN
      TIGR00614 (TIGR00614)
2. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      761 - 1,023
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      548 - 718
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      861 - 904
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
3. IPR014001
   Helicase, superfamily 1/2, ATP-binding domain
   1. SM00487 (DEXDc)
      569 - 770
      SMART
      SM00487 (DEXDc)
   2. PS51192 (HELICASE_A...)
      581 - 755
      PROSITE profiles
      PS51192 (HELICASE_ATP_BIND_1)
4. IPR011545
   DNA/RNA helicase, DEAD/DEAH box type, N-terminal
   1. PF00270 (DEAD)
      575 - 740
      Pfam
      PF00270 (DEAD)
5. IPR001650
   Helicase, C-terminal
   1. PF00271 (Helicase_C)
      812 - 887
      Pfam
      PF00271 (Helicase_C)
   2. PS51194 (HELICASE_CTER)
      778 - 927
      PROSITE profiles
      PS51194 (HELICASE_CTER)
   3. SM00490 (HELICc)
      806 - 887
      SMART
      SM00490 (HELICc)
6. IPR011991
   Winged helix-turn-helix DNA-binding domain
   1. G3DSA:1.10.10.10
      901 - 1,094
      GENE3D
      G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
7. IPR018982
   RQC domain
   1. PF09382 (RQC)
      977 - 1,090
      Pfam
      PF09382 (RQC)
   2. SM00956 (RQC)
      977 - 1,093
      SMART
      SM00956 (RQC)

no IPR
Unintegrated signatures

1. Coil
   1,195 - 1,216
   COILS
   Coil (Coil)
2. G3DSA:3.40.50...
   759 - 900
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   553 - 753
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
3. PTHR13710 (DNA HELI...)
   365 - 1,216
   PANTHER
   PTHR13710 (DNA HELICASE RECQ FAMILY MEMBER)
4. PTHR13710:SF14 (BLO...)
   365 - 1,216
   PANTHER
   PTHR13710:SF14 (BLOOMS SYNDROME DNA HELICASE)
5. SSF46785 ("Winged h...)
   974 - 1,095
   SUPERFAMILY
   SSF46785 ("Winged helix" DNA-binding domain)

### GO term prediction

#### Biological Process

GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination

#### Molecular Function

GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity

#### Cellular Component

None predicted.