Protein

## EMLSAP00000006113

Length
980 amino acids

### Protein family membership

- Leucine aminopeptidase/peptidase B (IPR011356)

### Domains and repeats

1. Domain
   5 - 73
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
     - Zinc finger, RING-type (IPR001841)
   232 - 569
   - WD40/YVTN repeat-like-containing domain (IPR015943)
     - WD40-repeat-containing domain (IPR017986)
   698 - 921
   - Peptidase M17, leucyl aminopeptidase, C-terminal (IPR000819)
2. Domain
   562 - 669
   - Peptidase M17, leucyl aminopeptidase, N-terminal (IPR008283)
3. Repeat
   250 - 295
   - WD40 repeat (IPR001680)
   306 - 345
   - WD40 repeat (IPR001680)
   348 - 430
   - WD40 repeat (IPR001680)
   434 - 514
   - WD40 repeat (IPR001680)
   525 - 571
   - WD40 repeat (IPR001680)

1 100 200 300 400 500 600 700 800 900 980

### Detailed signature matches

1. IPR011356
   Leucine aminopeptidase/peptidase B
   1. PR00481 (LAMNOPPTDASE)
      856 - 876
      PRINTS
      PR00481 (LAMNOPPTDASE)
      884 - 899
      PRINTS
      PR00481 (LAMNOPPTDASE)
      834 - 855
      PRINTS
      PR00481 (LAMNOPPTDASE)
      775 - 792
      PRINTS
      PR00481 (LAMNOPPTDASE)
      797 - 818
      PRINTS
      PR00481 (LAMNOPPTDASE)
   2. PTHR11963:SF3 (LEUC...)
      592 - 980
      PANTHER
      PTHR11963:SF3 (LEUCINE AMINOPEPTIDASE)
2. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10
      5 - 73
      GENE3D
      G3DSA:3.30.40.10 (G3DSA:3.30.40.10)
3. IPR001841
   Zinc finger, RING-type
   1. PS50089 (ZF_RING_2)
      12 - 50
      PROSITE profiles
      PS50089 (ZF_RING_2)
   2. SM00184 (RING)
      12 - 49
      SMART
      SM00184 (RING)
4. IPR015943
   WD40/YVTN repeat-like-containing domain
   1. G3DSA:2.130.1...
      232 - 567
      GENE3D
      G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
5. IPR017986
   WD40-repeat-containing domain
   1. SSF50978 (WD40 repe...)
      266 - 569
      SUPERFAMILY
      SSF50978 (WD40 repeat-like)
   2. PS50294 (WD_REPEATS...)
      263 - 523
      PROSITE profiles
      PS50294 (WD_REPEATS_REGION)
6. IPR008283
   Peptidase M17, leucyl aminopeptidase, N-terminal
   1. PF02789 (Peptidase_...)
      562 - 669
      Pfam
      PF02789 (Peptidase_M17_N)
7. IPR000819
   Peptidase M17, leucyl aminopeptidase, C-terminal
   1. PS00631 (CYTOSOL_AP)
      860 - 867
      PROSITE patterns
      PS00631 (CYTOSOL_AP)
   2. PF00883 (Peptidase_M17)
      698 - 921
      Pfam
      PF00883 (Peptidase_M17)
8. IPR001680
   WD40 repeat
   1. PS50082 (WD_REPEATS_2)
      355 - 397
      PROSITE profiles
      PS50082 (WD_REPEATS_2)
      441 - 481
      PROSITE profiles
      PS50082 (WD_REPEATS_2)
   2. SM00320 (WD40)
      391 - 430
      SMART
      SM00320 (WD40)
      525 - 571
      SMART
      SM00320 (WD40)
      434 - 472
      SMART
      SM00320 (WD40)
      475 - 514
      SMART
      SM00320 (WD40)
      250 - 295
      SMART
      SM00320 (WD40)
      348 - 388
      SMART
      SM00320 (WD40)
      306 - 345
      SMART
      SM00320 (WD40)
   3. PF00400 (WD40)
      352 - 388
      Pfam
      PF00400 (WD40)
      439 - 472
      Pfam
      PF00400 (WD40)
      402 - 430
      Pfam
      PF00400 (WD40)
9. IPR017907
   Zinc finger, RING-type, conserved site
   1. PS00518 (ZF_RING_1)
      27 - 36
      PROSITE patterns
      PS00518 (ZF_RING_1)
10. IPR019775
    WD40 repeat, conserved site
    1. PS00678 (WD_REPEATS_1)
       459 - 473
       PROSITE patterns
       PS00678 (WD_REPEATS_1)

no IPR
Unintegrated signatures

1. Coil
   88 - 109
   COILS
   Coil (Coil)
2. G3DSA:3.40.22...
   568 - 697
   GENE3D
   G3DSA:3.40.220.10 (G3DSA:3.40.220.10)
3. G3DSA:3.40.63...
   698 - 921
   GENE3D
   G3DSA:3.40.630.10 (G3DSA:3.40.630.10)
   924 - 979
   GENE3D
   G3DSA:3.40.630.10 (G3DSA:3.40.630.10)
4. PF13923 (zf-C3HC4_2)
   12 - 49
   Pfam
   PF13923 (zf-C3HC4_2)
5. PTHR11963 (LEUCINE ...)
   592 - 980
   PANTHER
   PTHR11963 (LEUCINE AMINOPEPTIDASE-RELATED)
6. SSF52949 (Macro dom...)
   573 - 688
   SUPERFAMILY
   SSF52949 (Macro domain-like)
7. SSF53187 (Zn-depend...)
   695 - 979
   SUPERFAMILY
   SSF53187 (Zn-dependent exopeptidases)
8. SSF57850 (RING/U-box)
   6 - 76
   SUPERFAMILY
   SSF57850 (RING/U-box)

### GO term prediction

#### Biological Process

GO:0006508 proteolysis
GO:0019538 protein metabolic process

#### Molecular Function

GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008270 zinc ion binding
GO:0030145 manganese ion binding

#### Cellular Component

GO:0005622 intracellular
GO:0005737 cytoplasm