Protein

## EMLSAP00000009640

Length
789 amino acids

### Protein family membership

- Small GTPase superfamily (IPR001806)
  - Small GTPase superfamily, Rab type (IPR003579)

- Dihydroorotate dehydrogenase, class 1/ 2 (IPR012135)
  - Dihydroorotate dehydrogenase, class 2 (IPR005719)

### Domains and repeats

1. Domain
   4 - 151
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   247 - 383
   - 4'-phosphopantetheinyl transferase superfamily (IPR008278)
   425 - 785
   - Aldolase-type TIM barrel (IPR013785)

1 100 200 300 400 500 600 700 789

### Detailed signature matches

1. IPR001806
   Small GTPase superfamily
   1. PR00449 (RASTRNSFRMNG)
      4 - 25
      PRINTS
      PR00449 (RASTRNSFRMNG)
      134 - 147
      PRINTS
      PR00449 (RASTRNSFRMNG)
   2. PF00071 (Ras)
      5 - 147
      Pfam
      PF00071 (Ras)
2. IPR003579
   Small GTPase superfamily, Rab type
   1. SM00175 (RAB)
      4 - 178
      SMART
      SM00175 (RAB)
3. IPR012135
   Dihydroorotate dehydrogenase, class 1/ 2
   1. PF01180 (DHO_dh)
      470 - 770
      Pfam
      PF01180 (DHO_dh)
4. IPR005719
   Dihydroorotate dehydrogenase, class 2
   1. TIGR01036
      433 - 784
      UNKNOWN
      TIGR01036 (TIGR01036)
5. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      4 - 151
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
6. IPR008278
   4'-phosphopantetheinyl transferase superfamily
   1. SSF56214 (4'-phosph...)
      247 - 383
      SUPERFAMILY
      SSF56214 (4'-phosphopantetheinyl transferase)
   2. G3DSA:3.90.47...
      248 - 368
      GENE3D
      G3DSA:3.90.470.20 (G3DSA:3.90.470.20)
   3. PF01648 (ACPS)
      247 - 361
      Pfam
      PF01648 (ACPS)
7. IPR013785
   Aldolase-type TIM barrel
   1. G3DSA:3.20.20.70
      425 - 785
      GENE3D
      G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
8. IPR025662
   Sigma-54 interaction domain, ATP-binding site 1
   1. PS00675 (SIGMA54_IN...)
      6 - 19
      PROSITE patterns
      PS00675 (SIGMA54_INTERACT_1)
9. IPR001295
   Dihydroorotate dehydrogenase, conserved site
   1. PS00911 (DHODEHASE_1)
      505 - 524
      PROSITE patterns
      PS00911 (DHODEHASE_1)
   2. PS00912 (DHODEHASE_2)
      722 - 742
      PROSITE patterns
      PS00912 (DHODEHASE_2)

no IPR
Unintegrated signatures

1. G3DSA:3.40.50...
   2 - 150
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
2. PS51419 (RAB)
   1 - 266
   PROSITE profiles
   PS51419 (RAB)
3. PTHR11938 (FAD NADP...)
   410 - 784
   PANTHER
   PTHR11938 (FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE)
4. SSF51395 (FMN-linke...)
   430 - 784
   SUPERFAMILY
   SSF51395 (FMN-linked oxidoreductases)

### GO term prediction

#### Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0007264 small GTPase mediated signal transduction
GO:0009059 macromolecule biosynthetic process
GO:0015031 protein transport
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004152 dihydroorotate dehydrogenase activity
GO:0004158 dihydroorotate oxidase activity
GO:0005525 GTP binding
GO:0008897 holo-[acyl-carrier-protein] synthase activity

#### Cellular Component

GO:0016020 membrane