Protein

## EMLSAP00000003944

Length
666 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   3 - 69
   - Src homology-3 domain (IPR001452)
   287 - 408
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
2. Domain
   97 - 292
   - Dbl homology (DH) domain (IPR000219)

1 100 200 300 400 500 600 666

### Detailed signature matches

1. IPR001452
   Src homology-3 domain
   1. SM00326 (SH3)
      6 - 63
      SMART
      SM00326 (SH3)
   2. PR00452 (SH3DOMAIN)
      6 - 16
      PRINTS
      PR00452 (SH3DOMAIN)
      20 - 35
      PRINTS
      PR00452 (SH3DOMAIN)
      37 - 46
      PRINTS
      PR00452 (SH3DOMAIN)
      50 - 62
      PRINTS
      PR00452 (SH3DOMAIN)
   3. SSF50044 (SH3-domain)
      7 - 69
      SUPERFAMILY
      SSF50044 (SH3-domain)
   4. PS50002 (SH3)
      3 - 64
      PROSITE profiles
      PS50002 (SH3)
2. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      105 - 280
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      97 - 292
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      105 - 278
      Pfam
      PF00621 (RhoGEF)
   4. G3DSA:1.20.90...
      99 - 286
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
   5. PS50010 (DH_2)
      101 - 281
      PROSITE profiles
      PS50010 (DH_2)
3. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      287 - 407
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
4. IPR001849
   Pleckstrin homology domain
   1. PF00169 (PH)
      323 - 402
      Pfam
      PF00169 (PH)
   2. SM00233 (PH)
      310 - 408
      SMART
      SM00233 (PH)
   3. PS50003 (PH_DOMAIN)
      309 - 406
      PROSITE profiles
      PS50003 (PH_DOMAIN)

no IPR
Unintegrated signatures

1. Coil
   282 - 303
   COILS
   Coil (Coil)
2. G3DSA:2.30.30.40
   6 - 63
   GENE3D
   G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
3. PF14604 (SH3_9)
   10 - 59
   Pfam
   PF14604 (SH3_9)
4. PTHR22826 (RHO GUAN...)
   2 - 452
   PANTHER
   PTHR22826 (RHO GUANINE EXCHANGE FACTOR-RELATED)
5. PTHR22826:SF16 (PAK...)
   2 - 452
   PANTHER
   PTHR22826:SF16 (PAK-INTERACTING EXCHANGE FACTOR RELATED)
6. SSF50729 (PH domain...)
   284 - 410
   SUPERFAMILY
   SSF50729 (PH domain-like)

### GO term prediction

#### Biological Process

GO:0035023 regulation of Rho protein signal transduction

#### Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

#### Cellular Component

None predicted.