Protein

## EMLSAP00000012222

Length
776 amino acids

### Protein family membership

- Histone lysine-specific demethylase (IPR017366)

### Domains and repeats

1. Domain
   97 - 194
   - Homeodomain-like (IPR009057)
     - SWIRM domain (IPR007526)
   211 - 747
   - Amine oxidase (IPR002937)
2. Domain
   98 - 196
   - Winged helix-turn-helix DNA-binding domain (IPR011991)
   201 - 255
   - NAD(P)-binding domain (IPR016040)

1 100 200 300 400 500 600 700 776

### Detailed signature matches

1. IPR017366
   Histone lysine-specific demethylase
   1. PIRSF038051 (Lys-Hi...)
      1 - 769
      PIRSF
      PIRSF038051 (Lys-Histone-de-mtase)
2. IPR009057
   Homeodomain-like
   1. SSF46689 (Homeodoma...)
      97 - 192
      SUPERFAMILY
      SSF46689 (Homeodomain-like)
3. IPR007526
   SWIRM domain
   1. PF04433 (SWIRM)
      100 - 185
      Pfam
      PF04433 (SWIRM)
   2. PS50934 (SWIRM)
      98 - 194
      PROSITE profiles
      PS50934 (SWIRM)
4. IPR011991
   Winged helix-turn-helix DNA-binding domain
   1. G3DSA:1.10.10.10
      98 - 196
      GENE3D
      G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
5. IPR016040
   NAD(P)-binding domain
   1. G3DSA:3.40.50...
      201 - 255
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
6. IPR002937
   Amine oxidase
   1. PF01593 (Amino_oxidase)
      211 - 747
      Pfam
      PF01593 (Amino_oxidase)

no IPR
Unintegrated signatures

1. G3DSA:1.10.28...
   329 - 443
   GENE3D
   G3DSA:1.10.287.80 (G3DSA:1.10.287.80)
2. G3DSA:3.90.66...
   470 - 688
   GENE3D
   G3DSA:3.90.660.10 (G3DSA:3.90.660.10)
3. PTHR10742 (AMINE OX...)
   104 - 758
   PANTHER
   PTHR10742 (AMINE OXIDASE)
4. PTHR10742:SF35 (LYS...)
   104 - 758
   PANTHER
   PTHR10742:SF35 (LYSINE-SPECIFIC HISTONE DEMETHYLASE 1)
5. SSF51905 (FAD/NAD(P...)
   203 - 589
   SUPERFAMILY
   SSF51905 (FAD/NAD(P)-binding domain)
   710 - 751
   SUPERFAMILY
   SSF51905 (FAD/NAD(P)-binding domain)
   670 - 675
   SUPERFAMILY
   SSF51905 (FAD/NAD(P)-binding domain)
6. SSF54373 (FAD-linke...)
   574 - 682
   SUPERFAMILY
   SSF54373 (FAD-linked reductases, C-terminal domain)

### GO term prediction

#### Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0034720 histone H3-K4 demethylation
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0003677 DNA binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding

#### Cellular Component

GO:0005634 nucleus