Protein

## EMLSAP00000007442

Length
1,423 amino acids

### Protein family membership

- Peptidase C2, calpain family (IPR022684)

- DNA primase large subunit, eukaryotic/archaeal (IPR007238)

- Non-structural maintenance of chromosomes element 1 (IPR011513)

### Domains and repeats

1. Domain
   2 - 73
   - MIT (IPR007330)
   80 - 157
   - MIT (IPR007330)
   196 - 525
   - Peptidase C2, calpain, catalytic domain (IPR001300)
   1,350 - 1,407
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
2. Domain
   525 - 659
   - Peptidase C2, calpain, large subunit, domain III (IPR022682)
   664 - 780
   - Peptidase C2, calpain, large subunit, domain III (IPR022682)
     - Peptidase C2, calpain, domain III (IPR022683)

1 200 400 600 800 1000 1200 1423

### Detailed signature matches

1. IPR022684
   Peptidase C2, calpain family
   1. PR00704 (CALPAIN)
      623 - 651
      PRINTS
      PR00704 (CALPAIN)
      337 - 360
      PRINTS
      PR00704 (CALPAIN)
      262 - 278
      PRINTS
      PR00704 (CALPAIN)
      494 - 515
      PRINTS
      PR00704 (CALPAIN)
2. IPR007238
   DNA primase large subunit, eukaryotic/archaeal
   1. PF04104 (DNA_primas...)
      939 - 1,190
      Pfam
      PF04104 (DNA_primase_lrg)
3. IPR011513
   Non-structural maintenance of chromosomes element 1
   1. PF07574 (SMC_Nse1)
      1,209 - 1,279
      Pfam
      PF07574 (SMC_Nse1)
4. IPR007330
   MIT
   1. SM00745 (MIT)
      80 - 157
      SMART
      SM00745 (MIT)
      2 - 73
      SMART
      SM00745 (MIT)
   2. PF04212 (MIT)
      85 - 149
      Pfam
      PF04212 (MIT)
5. IPR001300
   Peptidase C2, calpain, catalytic domain
   1. PS50203 (CALPAIN_CAT)
      238 - 518
      PROSITE profiles
      PS50203 (CALPAIN_CAT)
   2. SM00230 (CysPc)
      196 - 525
      SMART
      SM00230 (CysPc)
   3. PF00648 (Peptidase_C2)
      235 - 512
      Pfam
      PF00648 (Peptidase_C2)
6. IPR022682
   Peptidase C2, calpain, large subunit, domain III
   1. SSF49758 (Calpain l...)
      525 - 659
      SUPERFAMILY
      SSF49758 (Calpain large subunit, middle domain (domain III))
      669 - 777
      SUPERFAMILY
      SSF49758 (Calpain large subunit, middle domain (domain III))
   2. PF01067 (Calpain_III)
      664 - 777
      Pfam
      PF01067 (Calpain_III)
7. IPR022683
   Peptidase C2, calpain, domain III
   1. SM00720 (calpain_III)
      664 - 780
      SMART
      SM00720 (calpain_III)
8. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10
      1,350 - 1,407
      GENE3D
      G3DSA:3.30.40.10 (G3DSA:3.30.40.10)
9. IPR019786
   Zinc finger, PHD-type, conserved site
   1. PS01359 (ZF_PHD_1)
      1,354 - 1,399
      PROSITE patterns
      PS01359 (ZF_PHD_1)

no IPR
Unintegrated signatures

1. Coil
   53 - 74
   COILS
   Coil (Coil)
2. G3DSA:1.20.58...
   10 - 65
   GENE3D
   G3DSA:1.20.58.280 (G3DSA:1.20.58.280)
   79 - 153
   GENE3D
   G3DSA:1.20.58.280 (G3DSA:1.20.58.280)
3. G3DSA:2.60.12...
   525 - 651
   GENE3D
   G3DSA:2.60.120.380 (G3DSA:2.60.120.380)
   666 - 777
   GENE3D
   G3DSA:2.60.120.380 (G3DSA:2.60.120.380)
4. G3DSA:3.90.70.10
   391 - 459
   GENE3D
   G3DSA:3.90.70.10 (G3DSA:3.90.70.10)
   495 - 518
   GENE3D
   G3DSA:3.90.70.10 (G3DSA:3.90.70.10)
5. PTHR10183 (CALPAIN)
   6 - 990
   PANTHER
   PTHR10183 (CALPAIN)
6. PTHR10183:SF22 (CAL...)
   6 - 990
   PANTHER
   PTHR10183:SF22 (CALPAIN 7)
7. SSF116846 (MIT domain)
   7 - 68
   SUPERFAMILY
   SSF116846 (MIT domain)
   85 - 152
   SUPERFAMILY
   SSF116846 (MIT domain)
8. SSF54001 (Cysteine ...)
   183 - 528
   SUPERFAMILY
   SSF54001 (Cysteine proteinases)

### GO term prediction

#### Biological Process

GO:0006269 DNA replication, synthesis of RNA primer
GO:0006281 DNA repair
GO:0006508 proteolysis

#### Molecular Function

GO:0003896 DNA primase activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity

#### Cellular Component

GO:0005622 intracellular
GO:0030915 Smc5-Smc6 complex