Protein

## EMLSAP00000008664

Length
1,703 amino acids

### Protein family membership

- Pseudouridine synthase II (IPR002501)
  - tRNA pseudouridine synthase B family (IPR004802)

- Small-subunit processome, Utp11 (IPR007144)

- Vps54-like (IPR012501)

### Domains and repeats

1. Domain
   42 - 100
   - Dyskerin-like (IPR012960)
   282 - 371
   - PUA-like domain (IPR015947)
     - Pseudouridine synthase/archaeosine transglycosylase (IPR002478)
       - Uncharacterised domain CHP00451 (IPR004521)
2. Domain
   43 - 287
   - Pseudouridine synthase, catalytic domain (IPR020103)

1 200 400 600 800 1000 1200 1400 1600 1703

### Detailed signature matches

1. IPR002501
   Pseudouridine synthase II
   1. PF01509 (TruB_N)
      104 - 200
      Pfam
      PF01509 (TruB_N)
2. IPR004802
   tRNA pseudouridine synthase B family
   1. PTHR23127 (CENTROME...)
      1 - 501
      PANTHER
      PTHR23127 (CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5)
   2. TIGR00425
      50 - 374
      UNKNOWN
      TIGR00425 (TIGR00425)
3. IPR007144
   Small-subunit processome, Utp11
   1. PF03998 (Utp11)
      525 - 747
      Pfam
      PF03998 (Utp11)
4. IPR012501
   Vps54-like
   1. PF07928 (Vps54)
      1,456 - 1,588
      Pfam
      PF07928 (Vps54)
5. IPR012960
   Dyskerin-like
   1. PF08068 (DKCLD)
      42 - 100
      Pfam
      PF08068 (DKCLD)
6. IPR020103
   Pseudouridine synthase, catalytic domain
   1. SSF55120 (Pseudouri...)
      43 - 287
      SUPERFAMILY
      SSF55120 (Pseudouridine synthase)
7. IPR015947
   PUA-like domain
   1. SSF88697 (PUA domai...)
      289 - 370
      SUPERFAMILY
      SSF88697 (PUA domain-like)
   2. G3DSA:2.30.13...
      289 - 371
      GENE3D
      G3DSA:2.30.130.10 (G3DSA:2.30.130.10)
8. IPR002478
   Pseudouridine synthase/archaeosine transglycosylase
   1. SM00359 (PUA)
      290 - 364
      SMART
      SM00359 (PUA)
   2. PS50890 (PUA)
      289 - 364
      PROSITE profiles
      PS50890 (PUA)
   3. PF01472 (PUA)
      290 - 363
      Pfam
      PF01472 (PUA)
9. IPR004521
   Uncharacterised domain CHP00451
   1. TIGR00451
      282 - 360
      UNKNOWN
      TIGR00451 (TIGR00451)

no IPR
Unintegrated signatures

1. Coil
   1,557 - 1,578
   COILS
   Coil (Coil)

### GO term prediction

#### Biological Process

GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0009451 RNA modification
GO:0042147 retrograde transport, endosome to Golgi

#### Molecular Function

GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity

#### Cellular Component

GO:0032040 small-subunit processome