Protein

## EMLSAP00000012448

Length
1,100 amino acids

### Protein family membership

- GPCR, family 3, gamma-aminobutyric acid receptor, type B (IPR002455)
  - GPCR, family 3, gamma-aminobutyric acid receptor, type B1 (IPR002456)

### Domains and repeats

1. Domain
   7 - 94
   - Transcription factor IIS, N-terminal (IPR017923)
     - Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type (IPR003617)
   276 - 734
   - Periplasmic binding protein-like I (IPR028082)
   749 - 1,000
   - GPCR, family 3, C-terminal (IPR017978)
2. Domain
   298 - 681
   - Extracellular ligand-binding receptor (IPR001828)

1 200 400 600 800 1000 1100

### Detailed signature matches

1. IPR002455
   GPCR, family 3, gamma-aminobutyric acid receptor, type B
   1. PR01176 (GABABRECEPTR)
      873 - 898
      PRINTS
      PR01176 (GABABRECEPTR)
      960 - 983
      PRINTS
      PR01176 (GABABRECEPTR)
      821 - 840
      PRINTS
      PR01176 (GABABRECEPTR)
      911 - 931
      PRINTS
      PR01176 (GABABRECEPTR)
      840 - 857
      PRINTS
      PR01176 (GABABRECEPTR)
      295 - 311
      PRINTS
      PR01176 (GABABRECEPTR)
2. IPR002456
   GPCR, family 3, gamma-aminobutyric acid receptor, type B1
   1. PR01177 (GABAB1RECPTR)
      361 - 378
      PRINTS
      PR01177 (GABAB1RECPTR)
      964 - 986
      PRINTS
      PR01177 (GABAB1RECPTR)
3. IPR017923
   Transcription factor IIS, N-terminal
   1. PS51319 (TFIIS_N)
      11 - 83
      PROSITE profiles
      PS51319 (TFIIS_N)
   2. PF08711 (Med26)
      30 - 78
      Pfam
      PF08711 (Med26)
   3. SSF47676 (Conserved...)
      7 - 94
      SUPERFAMILY
      SSF47676 (Conserved domain common to transcription factors TFIIS, elongin A, CRSP70)
   4. G3DSA:1.20.93...
      8 - 94
      GENE3D
      G3DSA:1.20.930.10 (G3DSA:1.20.930.10)
4. IPR003617
   Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
   1. SM00509 (TFS2N)
      10 - 82
      SMART
      SM00509 (TFS2N)
5. IPR028082
   Periplasmic binding protein-like I
   1. SSF53822 (Periplasm...)
      276 - 734
      SUPERFAMILY
      SSF53822 (Periplasmic binding protein-like I)
6. IPR001828
   Extracellular ligand-binding receptor
   1. PF01094 (ANF_receptor)
      298 - 681
      Pfam
      PF01094 (ANF_receptor)
7. IPR017978
   GPCR, family 3, C-terminal
   1. PS50259 (G_PROTEIN_...)
      749 - 1,000
      PROSITE profiles
      PS50259 (G_PROTEIN_RECEP_F3_4)
   2. PF00003 (7tm_3)
      760 - 997
      Pfam
      PF00003 (7tm_3)

no IPR
Unintegrated signatures

1. G3DSA:3.40.50...
   275 - 420
   GENE3D
   G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
   591 - 678
   GENE3D
   G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
   679 - 734
   GENE3D
   G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
   428 - 543
   GENE3D
   G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
2. PTHR10519 (GABA-B R...)
   248 - 1,000
   PANTHER
   PTHR10519 (GABA-B RECEPTOR)
3. PTHR10519:SF3 (GAMM...)
   248 - 1,000
   PANTHER
   PTHR10519:SF3 (GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1)
4. TMhelix
   929 - 951
   TMHMM
   TMhelix (TMhelix)
   785 - 807
   TMHMM
   TMhelix (TMhelix)
   869 - 891
   TMHMM
   TMhelix (TMhelix)
   250 - 272
   TMHMM
   TMhelix (TMhelix)
   822 - 844
   TMHMM
   TMhelix (TMhelix)
   964 - 986
   TMHMM
   TMhelix (TMhelix)
   750 - 772
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006351 transcription, DNA-templated
GO:0007186 G-protein coupled receptor signaling pathway

#### Molecular Function

GO:0003677 DNA binding
GO:0004930 G-protein coupled receptor activity
GO:0004965 G-protein coupled GABA receptor activity

#### Cellular Component

GO:0005634 nucleus
GO:0016021 integral component of membrane