Protein

## EMLSAP00000008174

Length
2,123 amino acids

### Protein family membership

- Carbamoyl-phosphate synthase, small subunit (IPR006274)

- Carbamoyl-phosphate synthase, large subunit (IPR006275)

- Aspartate/ornithine carbamoyltransferase (IPR006130)
  - Aspartate carbamoyltransferase (IPR002082)

### Domains and repeats

1. Domain
   1 - 114
   - Carbamoyl-phosphate synthase, small subunit N-terminal domain (IPR002474)
   490 - 550
   - ATP-grasp fold, subdomain 1 (IPR013815)
   740 - 892
   - Carbamoyl-phosphate synthetase, large subunit oligomerisation domain (IPR005480)
   1,027 - 1,085
   - ATP-grasp fold, subdomain 1 (IPR013815)
   1,842 - 1,930
   - Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding (IPR006132)
   1,931 - 1,962
   - Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding (IPR006132)
2. Domain
   138 - 325
   - Glutamine amidotransferase (IPR017926)
   367 - 381
   - Carbamoyl-phosphate synthase large subunit, CPSase domain (IPR005483)
   396 - 406
   - Carbamoyl-phosphate synthase large subunit, CPSase domain (IPR005483)
   476 - 679
   - ATP-grasp fold (IPR011761)
     - Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain (IPR005479)
       - Carbamoyl-phosphate synthase large subunit, CPSase domain (IPR005483)
   724 - 742
   - Carbamoyl-phosphate synthase large subunit, CPSase domain (IPR005483)
   1,014 - 1,214
   - ATP-grasp fold (IPR011761)
     - Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain (IPR005479)
   1,272 - 1,429
   - Methylglyoxal synthase-like domain (IPR011607)
   1,439 - 1,664
   - Amidohydrolase 1 (IPR006680)
   1,690 - 1,696
   - Metal-dependent hydrolase, composite domain (IPR011059)
   1,723 - 1,785
   - Metal-dependent hydrolase, composite domain (IPR011059)
   1,968 - 2,119
   - Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain (IPR006131)
3. Domain
   307 - 474
   - Pre-ATP-grasp domain (IPR016185)
     - Carbamoyl-phosphate synthase, large subunit, N-terminal (IPR005481)
   551 - 744
   - ATP-grasp fold, subdomain 2 (IPR013816)
   876 - 1,014
   - Pre-ATP-grasp domain (IPR016185)
     - Carbamoyl-phosphate synthase, large subunit, N-terminal (IPR005481)
   1,086 - 1,271
   - ATP-grasp fold, subdomain 2 (IPR013816)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2123

### Detailed signature matches

1. IPR006274
   Carbamoyl-phosphate synthase, small subunit
   1. TIGR01368
      5 - 320
      UNKNOWN
      TIGR01368 (TIGR01368)
2. IPR006275
   Carbamoyl-phosphate synthase, large subunit
   1. TIGR01369
      352 - 1,414
      UNKNOWN
      TIGR01369 (TIGR01369)
3. IPR006130
   Aspartate/ornithine carbamoyltransferase
   1. PS00097 (CARBAMOYLT...)
      1,888 - 1,895
      PROSITE patterns
      PS00097 (CARBAMOYLTRANSFERASE)
   2. SSF53671 (Aspartate...)
      1,839 - 2,122
      SUPERFAMILY
      SSF53671 (Aspartate/ornithine carbamoyltransferase)
   3. PR00100 (AOTCASE)
      2,085 - 2,108
      PRINTS
      PR00100 (AOTCASE)
      1,888 - 1,907
      PRINTS
      PR00100 (AOTCASE)
      2,075 - 2,084
      PRINTS
      PR00100 (AOTCASE)
   4. G3DSA:3.40.50...
      1,931 - 1,956
      GENE3D
      G3DSA:3.40.50.1370 (G3DSA:3.40.50.1370)
      1,839 - 1,930
      GENE3D
      G3DSA:3.40.50.1370 (G3DSA:3.40.50.1370)
      1,957 - 2,107
      GENE3D
      G3DSA:3.40.50.1370 (G3DSA:3.40.50.1370)
4. IPR002082
   Aspartate carbamoyltransferase
   1. PR00101 (ATCASE)
      1,916 - 1,925
      PRINTS
      PR00101 (ATCASE)
      1,878 - 1,900
      PRINTS
      PR00101 (ATCASE)
      2,040 - 2,049
      PRINTS
      PR00101 (ATCASE)
      2,079 - 2,084
      PRINTS
      PR00101 (ATCASE)
      2,101 - 2,115
      PRINTS
      PR00101 (ATCASE)
5. IPR002474
   Carbamoyl-phosphate synthase, small subunit N-terminal domain
   1. G3DSA:3.50.30.20
      5 - 108
      GENE3D
      G3DSA:3.50.30.20 (G3DSA:3.50.30.20)
   2. SM01097 (CPSase_sm_...)
      1 - 103
      SMART
      SM01097 (CPSase_sm_chain)
   3. SSF52021 (Carbamoyl...)
      5 - 114
      SUPERFAMILY
      SSF52021 (Carbamoyl phosphate synthetase, small subunit N-terminal domain)
   4. PF00988 (CPSase_sm_...)
      5 - 102
      Pfam
      PF00988 (CPSase_sm_chain)
6. IPR017926
   Glutamine amidotransferase
   1. PS51273 (GATASE_TYPE_1)
      138 - 325
      PROSITE profiles
      PS51273 (GATASE_TYPE_1)
   2. PF00117 (GATase)
      141 - 317
      Pfam
      PF00117 (GATase)
7. IPR016185
   Pre-ATP-grasp domain
   1. SSF52440 (PreATP-gr...)
      898 - 1,014
      SUPERFAMILY
      SSF52440 (PreATP-grasp domain)
      351 - 474
      SUPERFAMILY
      SSF52440 (PreATP-grasp domain)
   2. G3DSA:3.40.50.20
      307 - 456
      GENE3D
      G3DSA:3.40.50.20 (G3DSA:3.40.50.20)
      876 - 1,002
      GENE3D
      G3DSA:3.40.50.20 (G3DSA:3.40.50.20)
8. IPR005481
   Carbamoyl-phosphate synthase, large subunit, N-terminal
   1. PF00289 (CPSase_L_c...)
      354 - 471
      Pfam
      PF00289 (CPSase_L_chain)
      902 - 1,008
      Pfam
      PF00289 (CPSase_L_chain)
9. IPR011761
   ATP-grasp fold
   1. PS50975 (ATP_GRASP)
      481 - 673
      PROSITE profiles
      PS50975 (ATP_GRASP)
      1,018 - 1,211
      PROSITE profiles
      PS50975 (ATP_GRASP)
10. IPR005479
    Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
    1. PF02786 (CPSase_L_D2)
       1,014 - 1,214
       Pfam
       PF02786 (CPSase_L_D2)
       476 - 679
       Pfam
       PF02786 (CPSase_L_D2)
    2. PS00866 (CPSASE_1)
       1,049 - 1,063
       PROSITE patterns
       PS00866 (CPSASE_1)
    3. PS00867 (CPSASE_2)
       642 - 649
       PROSITE patterns
       PS00867 (CPSASE_2)
       1,180 - 1,187
       PROSITE patterns
       PS00867 (CPSASE_2)
11. IPR005483
    Carbamoyl-phosphate synthase large subunit, CPSase domain
    1. PR00098 (CPSASE)
       396 - 406
       PRINTS
       PR00098 (CPSASE)
       585 - 602
       PRINTS
       PR00098 (CPSASE)
       642 - 671
       PRINTS
       PR00098 (CPSASE)
       724 - 742
       PRINTS
       PR00098 (CPSASE)
       516 - 528
       PRINTS
       PR00098 (CPSASE)
       367 - 381
       PRINTS
       PR00098 (CPSASE)
       550 - 569
       PRINTS
       PR00098 (CPSASE)
12. IPR013815
    ATP-grasp fold, subdomain 1
    1. G3DSA:3.30.14...
       1,027 - 1,085
       GENE3D
       G3DSA:3.30.1490.20 (G3DSA:3.30.1490.20)
       490 - 550
       GENE3D
       G3DSA:3.30.1490.20 (G3DSA:3.30.1490.20)
13. IPR013816
    ATP-grasp fold, subdomain 2
    1. G3DSA:3.30.47...
       551 - 744
       GENE3D
       G3DSA:3.30.470.20 (G3DSA:3.30.470.20)
       1,086 - 1,271
       GENE3D
       G3DSA:3.30.470.20 (G3DSA:3.30.470.20)
14. IPR005480
    Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
    1. SM01096 (CPSase_L_D3)
       761 - 885
       SMART
       SM01096 (CPSase_L_D3)
    2. PF02787 (CPSase_L_D3)
       762 - 885
       Pfam
       PF02787 (CPSase_L_D3)
    3. SSF48108 (Carbamoyl...)
       740 - 892
       SUPERFAMILY
       SSF48108 (Carbamoyl phosphate synthetase, large subunit connection domain)
    4. G3DSA:1.10.10...
       745 - 875
       GENE3D
       G3DSA:1.10.1030.10 (G3DSA:1.10.1030.10)
15. IPR011607
    Methylglyoxal synthase-like domain
    1. PF02142 (MGS)
       1,295 - 1,402
       Pfam
       PF02142 (MGS)
    2. SSF52335 (Methylgly...)
       1,281 - 1,429
       SUPERFAMILY
       SSF52335 (Methylglyoxal synthase-like)
    3. SM00851 (MGS)
       1,295 - 1,402
       SMART
       SM00851 (MGS)
    4. G3DSA:3.40.50...
       1,272 - 1,415
       GENE3D
       G3DSA:3.40.50.1380 (G3DSA:3.40.50.1380)
16. IPR006680
    Amidohydrolase 1
    1. PF01979 (Amidohydro_1)
       1,439 - 1,664
       Pfam
       PF01979 (Amidohydro_1)
17. IPR011059
    Metal-dependent hydrolase, composite domain
    1. SSF51338 (Composite...)
       1,723 - 1,785
       SUPERFAMILY
       SSF51338 (Composite domain of metallo-dependent hydrolases)
       1,690 - 1,696
       SUPERFAMILY
       SSF51338 (Composite domain of metallo-dependent hydrolases)
18. IPR006132
    Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
    1. PF02729 (OTCace_N)
       1,842 - 1,930
       Pfam
       PF02729 (OTCace_N)
       1,931 - 1,962
       Pfam
       PF02729 (OTCace_N)
19. IPR006131
    Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
    1. PF00185 (OTCace)
       1,968 - 2,119
       Pfam
       PF00185 (OTCace)
20. IPR002195
    Dihydroorotase, conserved site
    1. PS00483 (DIHYDROORO...)
       1,656 - 1,667
       PROSITE patterns
       PS00483 (DIHYDROOROTASE_2)

no IPR
Unintegrated signatures

1. G3DSA:3.20.20...
   1,442 - 1,750
   GENE3D
   G3DSA:3.20.20.140 (G3DSA:3.20.20.140)
2. G3DSA:3.40.50...
   117 - 306
   GENE3D
   G3DSA:3.40.50.880 (G3DSA:3.40.50.880)
3. PR00099 (CPSGATASE)
   209 - 225
   PRINTS
   PR00099 (CPSGATASE)
   139 - 153
   PRINTS
   PR00099 (CPSGATASE)
   226 - 243
   PRINTS
   PR00099 (CPSGATASE)
   177 - 191
   PRINTS
   PR00099 (CPSGATASE)
   251 - 262
   PRINTS
   PR00099 (CPSGATASE)
4. PTHR11405 (CARBAMOY...)
   5 - 2,088
   PANTHER
   PTHR11405 (CARBAMOYLTRANSFERASE RELATED)
5. PTHR11405:SF3 (CARB...)
   5 - 2,088
   PANTHER
   PTHR11405:SF3 (CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN)
6. SSF51556 (Metallo-d...)
   1,441 - 1,716
   SUPERFAMILY
   SSF51556 (Metallo-dependent hydrolases)
7. SSF52317 (Class I g...)
   117 - 320
   SUPERFAMILY
   SSF52317 (Class I glutamine amidotransferase-like)
8. SSF56059 (Glutathio...)
   476 - 745
   SUPERFAMILY
   SSF56059 (Glutathione synthetase ATP-binding domain-like)
   1,013 - 1,273
   SUPERFAMILY
   SSF56059 (Glutathione synthetase ATP-binding domain-like)

### GO term prediction

#### Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006520 cellular amino acid metabolic process
GO:0006543 glutamine catabolic process
GO:0006807 nitrogen compound metabolic process
GO:0008152 metabolic process
GO:0070409 carbamoyl phosphate biosynthetic process

#### Molecular Function

GO:0003824 catalytic activity
GO:0004070 aspartate carbamoyltransferase activity
GO:0005524 ATP binding
GO:0016597 amino acid binding
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0046872 metal ion binding

#### Cellular Component

None predicted.