Protein

## EMLSAP00000012434

Length
382 amino acids

### Protein family membership

- tRNA-specific 2-thiouridylase (IPR004506)

### Domains and repeats

1. Domain
   3 - 220
   - Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
   222 - 284
   - Adenine nucleotide alpha hydrolase-like domains (IPR023382)

1 50 100 150 200 250 300 350 382

### Detailed signature matches

1. IPR004506
   tRNA-specific 2-thiouridylase
   1. PTHR11933 (TRNA (5-...)
      1 - 376
      PANTHER
      PTHR11933 (TRNA (5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE)
   2. TIGR00420
      4 - 370
      UNKNOWN
      TIGR00420 (TIGR00420)
   3. PF03054 (tRNA_Me_trans)
      4 - 370
      Pfam
      PF03054 (tRNA_Me_trans)
   4. MF_00144 (tRNA_thio...)
      3 - 371
      HAMAP
      MF_00144 (tRNA_thiouridyl_MnmA)
2. IPR014729
   Rossmann-like alpha/beta/alpha sandwich fold
   1. G3DSA:3.40.50...
      3 - 220
      GENE3D
      G3DSA:3.40.50.620 (G3DSA:3.40.50.620)
3. IPR023382
   Adenine nucleotide alpha hydrolase-like domains
   1. G3DSA:2.30.30...
      222 - 284
      GENE3D
      G3DSA:2.30.30.280 (G3DSA:2.30.30.280)

no IPR
Unintegrated signatures

1. G3DSA:2.40.30.10
   286 - 378
   GENE3D
   G3DSA:2.40.30.10 (G3DSA:2.40.30.10)
2. PTHR11933:SF0 (SUBF...)
   1 - 376
   PANTHER
   PTHR11933:SF0 (SUBFAMILY NOT NAMED)
3. SSF52402 (Adenine n...)
   4 - 253
   SUPERFAMILY
   SSF52402 (Adenine nucleotide alpha hydrolases-like)

### GO term prediction

#### Biological Process

GO:0008033 tRNA processing

#### Molecular Function

GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity

#### Cellular Component

GO:0005737 cytoplasm