Protein

## EMLSAP00000005441

Length
832 amino acids

### Protein family membership

- Dopamine beta-hydroxylase-related (IPR000945)
  - Tyramine beta-hydroxylase (IPR028460)

### Domains and repeats

1. Domain
   54 - 204
   - DOMON domain (IPR005018)
   209 - 366
   - Copper type II, ascorbate-dependent monooxygenase, N-terminal (IPR000323)
   370 - 528
   - Copper type II, ascorbate-dependent monooxygenase-like, C-terminal (IPR014784)
2. Domain
   206 - 362
   - PHM/PNGase F domain (IPR008977)
3. Domain
   362 - 528
   - PHM/PNGase F domain (IPR008977)

1 100 200 300 400 500 600 700 832

### Detailed signature matches

1. IPR000945
   Dopamine beta-hydroxylase-related
   1. PR00767 (DBMONOXGNASE)
      74 - 96
      PRINTS
      PR00767 (DBMONOXGNASE)
      366 - 383
      PRINTS
      PR00767 (DBMONOXGNASE)
      255 - 273
      PRINTS
      PR00767 (DBMONOXGNASE)
      302 - 321
      PRINTS
      PR00767 (DBMONOXGNASE)
   2. PTHR10157 (DOPAMINE...)
      59 - 635
      PANTHER
      PTHR10157 (DOPAMINE BETA HYDROXYLASE RELATED)
2. IPR028460
   Tyramine beta-hydroxylase
   1. PTHR10157:SF4 (TYRA...)
      59 - 635
      PANTHER
      PTHR10157:SF4 (TYRAMINE BETA-HYDROXYLASE)
3. IPR005018
   DOMON domain
   1. SM00664 (DoH)
      55 - 204
      SMART
      SM00664 (DoH)
   2. PF03351 (DOMON)
      58 - 172
      Pfam
      PF03351 (DOMON)
   3. PS50836 (DOMON)
      54 - 172
      PROSITE profiles
      PS50836 (DOMON)
4. IPR008977
   PHM/PNGase F domain
   1. SSF49742 (PHM/PNGase F)
      206 - 362
      SUPERFAMILY
      SSF49742 (PHM/PNGase F)
      362 - 528
      SUPERFAMILY
      SSF49742 (PHM/PNGase F)
5. IPR000323
   Copper type II, ascorbate-dependent monooxygenase, N-terminal
   1. PF01082 (Cu2_monoox...)
      221 - 346
      Pfam
      PF01082 (Cu2_monooxygen)
   2. G3DSA:2.60.12...
      209 - 366
      GENE3D
      G3DSA:2.60.120.310 (G3DSA:2.60.120.310)
6. IPR014784
   Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
   1. G3DSA:2.60.12...
      370 - 528
      GENE3D
      G3DSA:2.60.120.230 (G3DSA:2.60.120.230)
7. IPR020611
   Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
   1. PS00084 (CU2_MONOOX...)
      265 - 272
      PROSITE patterns
      PS00084 (CU2_MONOOXYGENASE_1)

no IPR
Unintegrated signatures

1. PF03712 (Cu2_monoox_C)
   363 - 524
   Pfam
   PF03712 (Cu2_monoox_C)
2. TMhelix
   19 - 41
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0005507 copper ion binding
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

#### Cellular Component

None predicted.