Protein

## EMLSAP00000003617

Length
584 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   29 - 239
   - Dbl homology (DH) domain (IPR000219)
2. Domain
   237 - 358
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)

1 100 200 300 400 500 584

### Detailed signature matches

1. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      50 - 221
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      29 - 239
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      51 - 220
      Pfam
      PF00621 (RhoGEF)
   4. PS50010 (DH_2)
      46 - 222
      PROSITE profiles
      PS50010 (DH_2)
   5. G3DSA:1.20.90...
      32 - 236
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
2. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      237 - 358
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
3. IPR001849
   Pleckstrin homology domain
   1. PF00169 (PH)
      255 - 356
      Pfam
      PF00169 (PH)
   2. SM00233 (PH)
      253 - 358
      SMART
      SM00233 (PH)
   3. PS50003 (PH_DOMAIN)
      252 - 356
      PROSITE profiles
      PS50003 (PH_DOMAIN)
4. IPR001331
   Guanine-nucleotide dissociation stimulator, CDC24, conserved site
   1. PS00741 (DH_1)
      170 - 195
      PROSITE patterns
      PS00741 (DH_1)

no IPR
Unintegrated signatures

1. Coil
   348 - 369
   COILS
   Coil (Coil)
2. PTHR12673 (FACIOGEN...)
   1 - 564
   PANTHER
   PTHR12673 (FACIOGENITAL DYSPLASIA PROTEIN)
3. SSF50729 (PH domain...)
   233 - 361
   SUPERFAMILY
   SSF50729 (PH domain-like)

### GO term prediction

#### Biological Process

GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction

#### Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity

#### Cellular Component

None predicted.