Protein

## EMLSAP00000012037

Length
372 amino acids

### Protein family membership

- Peptidase S54, rhomboid (IPR002610)

### Domains and repeats

1. Domain
   23 - 92
   - EF-hand domain pair (IPR011992)
2. Domain
   63 - 98
   - EF-hand domain (IPR002048)
   134 - 323
   - Peptidase S54, rhomboid domain (IPR022764)

1 50 100 150 200 250 300 372

### Detailed signature matches

1. IPR002610
   Peptidase S54, rhomboid
   1. PTHR22936 (RHOMBOID...)
      65 - 364
      PANTHER
      PTHR22936 (RHOMBOID-RELATED)
2. IPR011992
   EF-hand domain pair
   1. G3DSA:1.10.23...
      23 - 92
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
3. IPR002048
   EF-hand domain
   1. PS50222 (EF_HAND_2)
      63 - 98
      PROSITE profiles
      PS50222 (EF_HAND_2)
   2. SM00054 (EFh)
      67 - 95
      SMART
      SM00054 (EFh)
   3. PF00036 (EF-hand_1)
      70 - 93
      Pfam
      PF00036 (EF-hand_1)
4. IPR022764
   Peptidase S54, rhomboid domain
   1. PF01694 (Rhomboid)
      174 - 323
      Pfam
      PF01694 (Rhomboid)
   2. G3DSA:1.20.15...
      134 - 321
      GENE3D
      G3DSA:1.20.1540.10 (G3DSA:1.20.1540.10)
5. IPR018247
   EF-Hand 1, calcium-binding site
   1. PS00018 (EF_HAND_1)
      76 - 88
      PROSITE patterns
      PS00018 (EF_HAND_1)

no IPR
Unintegrated signatures

1. SSF144091 (Rhomboid...)
   132 - 324
   SUPERFAMILY
   SSF144091 (Rhomboid-like)
2. SSF47473 (EF-hand)
   22 - 98
   SUPERFAMILY
   SSF47473 (EF-hand)
3. TMhelix
   300 - 319
   TMHMM
   TMhelix (TMhelix)
   184 - 206
   TMHMM
   TMhelix (TMhelix)
   213 - 235
   TMHMM
   TMhelix (TMhelix)
   273 - 295
   TMHMM
   TMhelix (TMhelix)
   331 - 353
   TMHMM
   TMhelix (TMhelix)
   239 - 261
   TMHMM
   TMhelix (TMhelix)
   129 - 151
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006508 proteolysis

#### Molecular Function

GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding

#### Cellular Component

GO:0016021 integral component of membrane