Protein

## EMLSAP00000008576

Length
464 amino acids

### Protein family membership

- Transcription regulator SKI/SnoN (IPR023216)
  - SKI family transcriptional corepressor 2 (IPR028376)

### Domains and repeats

1. Domain
   33 - 138
   - DNA binding domain, putative (IPR009061)
     - Transforming protein Ski (IPR003380)
   148 - 242
   - SAND domain-like (IPR010919)
     - c-SKI SMAD4-binding domain (IPR014890)

1 50 100 150 200 250 300 350 400 464

### Detailed signature matches

1. IPR023216
   Transcription regulator SKI/SnoN
   1. PTHR10005 (SKI ONCO...)
      42 - 248
      PANTHER
      PTHR10005 (SKI ONCOGENE-RELATED)
2. IPR028376
   SKI family transcriptional corepressor 2
   1. PTHR10005:SF7 (LADY...)
      42 - 248
      PANTHER
      PTHR10005:SF7 (LADYBIRD HOMEOBOX COREPRESSOR 1-LIKE PROTEIN)
3. IPR009061
   DNA binding domain, putative
   1. SSF46955 (Putative ...)
      43 - 138
      SUPERFAMILY
      SSF46955 (Putative DNA-binding domain)
4. IPR003380
   Transforming protein Ski
   1. PF02437 (Ski_Sno)
      33 - 137
      Pfam
      PF02437 (Ski_Sno)
   2. G3DSA:3.10.26...
      43 - 138
      GENE3D
      G3DSA:3.10.260.20 (G3DSA:3.10.260.20)
5. IPR010919
   SAND domain-like
   1. SSF63763 (SAND doma...)
      150 - 242
      SUPERFAMILY
      SSF63763 (SAND domain-like)
   2. G3DSA:3.10.39...
      148 - 242
      GENE3D
      G3DSA:3.10.390.10 (G3DSA:3.10.390.10)
6. IPR014890
   c-SKI SMAD4-binding domain
   1. SM01046 (c-SKI_SMAD...)
      150 - 242
      SMART
      SM01046 (c-SKI_SMAD_bind)
   2. PF08782 (c-SKI_SMAD...)
      150 - 242
      Pfam
      PF08782 (c-SKI_SMAD_bind)

### GO term prediction

#### Biological Process

GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway

#### Molecular Function

GO:0003714 transcription corepressor activity
GO:0046332 SMAD binding

#### Cellular Component

GO:0005634 nucleus
GO:0005737 cytoplasm