Protein

## EMLSAP00000005595

Length
700 amino acids

### Protein family membership

- Ubiquitin binding protein, Hrs/VPS27 (IPR017073)
  - Hepatocyte growth factor-regulated tyrosine kinase substrate (IPR027426)

### Domains and repeats

1. Domain
   5 - 148
   - ENTH/VHS (IPR008942)
     - VHS (IPR002014)
       - VHS subgroup (IPR018205)
   164 - 224
   - Zinc finger, FYVE-related (IPR017455)
   400 - 494
   - Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain (IPR024641)
2. Domain
   159 - 225
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
     - Zinc finger, FYVE/PHD-type (IPR011011)
       - FYVE zinc finger (IPR000306)

1 100 200 300 400 500 600 700 700

### Detailed signature matches

1. IPR017073
   Ubiquitin binding protein, Hrs/VPS27
   1. PIRSF036956 (Hrs_Vps27)
      1 - 700
      PIRSF
      PIRSF036956 (Hrs_Vps27)
2. IPR027426
   Hepatocyte growth factor-regulated tyrosine kinase substrate
   1. PTHR13856:SF45 (HEP...)
      1 - 577
      PANTHER
      PTHR13856:SF45 (HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE (HGS))
3. IPR008942
   ENTH/VHS
   1. G3DSA:1.25.40.90
      8 - 148
      GENE3D
      G3DSA:1.25.40.90 (G3DSA:1.25.40.90)
   2. SSF48464 (ENTH/VHS ...)
      5 - 148
      SUPERFAMILY
      SSF48464 (ENTH/VHS domain)
4. IPR002014
   VHS
   1. PF00790 (VHS)
      10 - 143
      Pfam
      PF00790 (VHS)
   2. PS50179 (VHS)
      19 - 147
      PROSITE profiles
      PS50179 (VHS)
5. IPR018205
   VHS subgroup
   1. SM00288 (VHS)
      12 - 143
      SMART
      SM00288 (VHS)
6. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10
      160 - 222
      GENE3D
      G3DSA:3.30.40.10 (G3DSA:3.30.40.10)
7. IPR011011
   Zinc finger, FYVE/PHD-type
   1. SSF57903 (FYVE/PHD ...)
      167 - 223
      SUPERFAMILY
      SSF57903 (FYVE/PHD zinc finger)
8. IPR000306
   FYVE zinc finger
   1. SM00064 (FYVE)
      159 - 225
      SMART
      SM00064 (FYVE)
   2. PF01363 (FYVE)
      168 - 222
      Pfam
      PF01363 (FYVE)
9. IPR017455
   Zinc finger, FYVE-related
   1. PS50178 (ZF_FYVE)
      164 - 224
      PROSITE profiles
      PS50178 (ZF_FYVE)
10. IPR024641
    Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain
    1. PF12210 (Hrs_helical)
       400 - 494
       Pfam
       PF12210 (Hrs_helical)
11. IPR003903
    Ubiquitin interacting motif
    1. PS50330 (UIM)
       272 - 291
       PROSITE profiles
       PS50330 (UIM)

no IPR
Unintegrated signatures

1. Coil
   460 - 506
   COILS
   Coil (Coil)
   272 - 295
   COILS
   Coil (Coil)
2. PTHR13856 (VHS DOMA...)
   1 - 577
   PANTHER
   PTHR13856 (VHS DOMAIN CONTAINING PROTEIN FAMILY)

### GO term prediction

#### Biological Process

GO:0006886 intracellular protein transport
GO:0009966 regulation of signal transduction
GO:0016197 endosomal transport

#### Molecular Function

GO:0046872 metal ion binding

#### Cellular Component

None predicted.