Protein

## EMLSAP00000003749

Length
1,699 amino acids

### Protein family membership

- Ran GTPase-activating protein (IPR027038)

### Domains and repeats

1. Domain
   28 - 131
   - Tetratricopeptide repeat-containing domain (IPR013026)
2. Domain
   34 - 148
   - Tetratricopeptide-like helical (IPR011990)
   504 - 547
   - Pleckstrin homology-like domain (IPR011993)
     - Ran binding domain (IPR000156)
   615 - 644
   - Zinc finger, RanBP2-type (IPR001876)
   913 - 942
   - Zinc finger, RanBP2-type (IPR001876)
   1,424 - 1,560
   - Pleckstrin homology-like domain (IPR011993)
     - Ran binding domain (IPR000156)
   1,619 - 1,685
   - Pleckstrin homology-like domain (IPR011993)
3. Repeat
   1,030 - 1,057
   - Leucine-rich repeat, ribonuclease inhibitor subtype (IPR003590)
   1,093 - 1,120
   - Leucine-rich repeat, ribonuclease inhibitor subtype (IPR003590)
   1,123 - 1,150
   - Leucine-rich repeat, ribonuclease inhibitor subtype (IPR003590)
   1,189 - 1,216
   - Leucine-rich repeat, ribonuclease inhibitor subtype (IPR003590)
   1,217 - 1,244
   - Leucine-rich repeat, ribonuclease inhibitor subtype (IPR003590)
   1,245 - 1,272
   - Leucine-rich repeat, ribonuclease inhibitor subtype (IPR003590)
   1,274 - 1,301
   - Leucine-rich repeat, ribonuclease inhibitor subtype (IPR003590)

1 200 400 600 800 1000 1200 1400 1699

### Detailed signature matches

1. IPR027038
   Ran GTPase-activating protein
   1. PTHR24113 (FAMILY N...)
      995 - 1,322
      PANTHER
      PTHR24113 (FAMILY NOT NAMED)
2. IPR013026
   Tetratricopeptide repeat-containing domain
   1. PS50293 (TPR_REGION)
      28 - 131
      PROSITE profiles
      PS50293 (TPR_REGION)
3. IPR011990
   Tetratricopeptide-like helical
   1. G3DSA:1.25.40.10
      34 - 148
      GENE3D
      G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
4. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      512 - 547
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
      1,432 - 1,559
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
      1,619 - 1,685
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
5. IPR000156
   Ran binding domain
   1. PF00638 (Ran_BP1)
      516 - 547
      Pfam
      PF00638 (Ran_BP1)
      1,437 - 1,556
      Pfam
      PF00638 (Ran_BP1)
   2. SM00160 (RanBD)
      1,425 - 1,554
      SMART
      SM00160 (RanBD)
   3. PS50196 (RANBD1)
      1,424 - 1,560
      PROSITE profiles
      PS50196 (RANBD1)
      504 - 547
      PROSITE profiles
      PS50196 (RANBD1)
6. IPR001876
   Zinc finger, RanBP2-type
   1. PS01358 (ZF_RANBP2_1)
      619 - 638
      PROSITE patterns
      PS01358 (ZF_RANBP2_1)
      917 - 936
      PROSITE patterns
      PS01358 (ZF_RANBP2_1)
   2. PS50199 (ZF_RANBP2_2)
      913 - 942
      PROSITE profiles
      PS50199 (ZF_RANBP2_2)
      615 - 644
      PROSITE profiles
      PS50199 (ZF_RANBP2_2)
   3. PF00641 (zf-RanBP)
      914 - 938
      Pfam
      PF00641 (zf-RanBP)
      615 - 643
      Pfam
      PF00641 (zf-RanBP)
   4. SM00547 (ZnF_RBZ)
      617 - 641
      SMART
      SM00547 (ZnF_RBZ)
      915 - 939
      SMART
      SM00547 (ZnF_RBZ)
7. IPR003590
   Leucine-rich repeat, ribonuclease inhibitor subtype
   1. SM00368 (LRR_RI)
      1,217 - 1,244
      SMART
      SM00368 (LRR_RI)
      1,274 - 1,301
      SMART
      SM00368 (LRR_RI)
      1,030 - 1,057
      SMART
      SM00368 (LRR_RI)
      1,189 - 1,216
      SMART
      SM00368 (LRR_RI)
      1,123 - 1,150
      SMART
      SM00368 (LRR_RI)
      1,093 - 1,120
      SMART
      SM00368 (LRR_RI)
      1,245 - 1,272
      SMART
      SM00368 (LRR_RI)

no IPR
Unintegrated signatures

1. Coil
   196 - 217
   COILS
   Coil (Coil)
   295 - 316
   COILS
   Coil (Coil)
2. G3DSA:3.80.10.10
   1,008 - 1,321
   GENE3D
   G3DSA:3.80.10.10 (G3DSA:3.80.10.10)
3. PF13516 (LRR_6)
   1,217 - 1,240
   Pfam
   PF13516 (LRR_6)
   1,245 - 1,267
   Pfam
   PF13516 (LRR_6)
4. SSF48452 (TPR-like)
   35 - 136
   SUPERFAMILY
   SSF48452 (TPR-like)
5. SSF50729 (PH domain...)
   1,605 - 1,688
   SUPERFAMILY
   SSF50729 (PH domain-like)
   503 - 577
   SUPERFAMILY
   SSF50729 (PH domain-like)
   1,424 - 1,555
   SUPERFAMILY
   SSF50729 (PH domain-like)
6. SSF52047 (RNI-like)
   1,004 - 1,320
   SUPERFAMILY
   SSF52047 (RNI-like)
7. SSF90209 (Ran bindi...)
   616 - 643
   SUPERFAMILY
   SSF90209 (Ran binding protein zinc finger-like)
   914 - 941
   SUPERFAMILY
   SSF90209 (Ran binding protein zinc finger-like)

### GO term prediction

#### Biological Process

GO:0046907 intracellular transport

#### Molecular Function

GO:0005098 Ran GTPase activator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding

#### Cellular Component

None predicted.