Protein

## EMLSAP00000006457

Length
2,583 amino acids

### Protein family membership

- Spo11/DNA topoisomerase VI, subunit A (IPR002815)

- Phosphatidylinositol Kinase (IPR015433)

### Domains and repeats

1. Domain
   45 - 179
   - Winged helix-turn-helix DNA-binding domain (IPR011991)
   2,211 - 2,580
   - Protein kinase-like domain (IPR011009)
     - Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
2. Domain
   116 - 178
   - Spo11/DNA topoisomerase VI, subunit A, N-terminal (IPR013049)
   2,020 - 2,216
   - Armadillo-type fold (IPR016024)
     - Phosphoinositide 3-kinase, accessory (PIK) domain (IPR001263)

1 500 1000 1500 2000 2583

### Detailed signature matches

1. IPR002815
   Spo11/DNA topoisomerase VI, subunit A
   1. SSF56726 (DNA topoi...)
      117 - 344
      SUPERFAMILY
      SSF56726 (DNA topoisomerase IV, alpha subunit)
   2. PR01550 (TOP6AFAMILY)
      252 - 273
      PRINTS
      PR01550 (TOP6AFAMILY)
      140 - 151
      PRINTS
      PR01550 (TOP6AFAMILY)
      154 - 171
      PRINTS
      PR01550 (TOP6AFAMILY)
      172 - 187
      PRINTS
      PR01550 (TOP6AFAMILY)
2. IPR015433
   Phosphatidylinositol Kinase
   1. PTHR10048 (PHOSPHAT...)
      743 - 2,583
      PANTHER
      PTHR10048 (PHOSPHATIDYLINOSITOL KINASE)
3. IPR011991
   Winged helix-turn-helix DNA-binding domain
   1. G3DSA:1.10.10.10
      45 - 179
      GENE3D
      G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
4. IPR013049
   Spo11/DNA topoisomerase VI, subunit A, N-terminal
   1. PF04406 (TP6A_N)
      116 - 178
      Pfam
      PF04406 (TP6A_N)
5. IPR016024
   Armadillo-type fold
   1. SSF48371 (ARM repeat)
      2,020 - 2,197
      SUPERFAMILY
      SSF48371 (ARM repeat)
6. IPR001263
   Phosphoinositide 3-kinase, accessory (PIK) domain
   1. PF00613 (PI3Ka)
      2,068 - 2,209
      Pfam
      PF00613 (PI3Ka)
   2. PS51545 (PIK_HELICAL)
      2,024 - 2,199
      PROSITE profiles
      PS51545 (PIK_HELICAL)
   3. SM00145 (PI3Ka)
      2,025 - 2,216
      SMART
      SM00145 (PI3Ka)
   4. G3DSA:1.25.40.70
      2,086 - 2,196
      GENE3D
      G3DSA:1.25.40.70 (G3DSA:1.25.40.70)
7. IPR011009
   Protein kinase-like domain
   1. SSF56112 (Protein k...)
      2,211 - 2,576
      SUPERFAMILY
      SSF56112 (Protein kinase-like (PK-like))
8. IPR000403
   Phosphatidylinositol 3-/4-kinase, catalytic domain
   1. G3DSA:1.10.10...
      2,375 - 2,571
      GENE3D
      G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
   2. PS50290 (PI3_4_KINA...)
      2,328 - 2,562
      PROSITE profiles
      PS50290 (PI3_4_KINASE_3)
   3. PF00454 (PI3_PI4_ki...)
      2,329 - 2,531
      Pfam
      PF00454 (PI3_PI4_kinase)
   4. SM00146 (PI3Kc)
      2,329 - 2,580
      SMART
      SM00146 (PI3Kc)
9. IPR018936
   Phosphatidylinositol 3/4-kinase, conserved site
   1. PS00915 (PI3_4_KINA...)
      2,332 - 2,346
      PROSITE patterns
      PS00915 (PI3_4_KINASE_1)
   2. PS00916 (PI3_4_KINA...)
      2,423 - 2,443
      PROSITE patterns
      PS00916 (PI3_4_KINASE_2)

no IPR
Unintegrated signatures

1. G3DSA:3.30.10...
   2,211 - 2,374
   GENE3D
   G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
2. G3DSA:3.40.13...
   181 - 281
   GENE3D
   G3DSA:3.40.1360.10 (G3DSA:3.40.1360.10)
3. PTHR10048:SF15 (PHO...)
   743 - 2,583
   PANTHER
   PTHR10048:SF15 (PHOSPHATIDYLINOSITOL 4-KINASE ALPHA)
4. TMhelix
   1,281 - 1,303
   TMHMM
   TMhelix (TMhelix)
   1,135 - 1,157
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006259 DNA metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling

#### Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0005488 binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor

#### Cellular Component

GO:0005694 chromosome