Protein

## EMLSAP00000007361

Length
545 amino acids

### Protein family membership

- Steroid hormone receptor (IPR001723)
  - Retinoid X receptor/HNF4 (IPR000003)

### Domains and repeats

1. Domain
   148 - 223
   - Zinc finger, NHR/GATA-type (IPR013088)
     - Zinc finger, nuclear hormone receptor-type (IPR001628)
   290 - 472
   - Nuclear hormone receptor, ligand-binding, core (IPR000536)
2. Domain
   214 - 486
   - Nuclear hormone receptor, ligand-binding (IPR008946)

1 50 100 150 200 250 300 350 400 450 500 545

### Detailed signature matches

1. IPR001723
   Steroid hormone receptor
   1. PR00398 (STRDHORMONER)
      391 - 406
      PRINTS
      PR00398 (STRDHORMONER)
      296 - 317
      PRINTS
      PR00398 (STRDHORMONER)
      448 - 465
      PRINTS
      PR00398 (STRDHORMONER)
      212 - 222
      PRINTS
      PR00398 (STRDHORMONER)
      317 - 333
      PRINTS
      PR00398 (STRDHORMONER)
2. IPR000003
   Retinoid X receptor/HNF4
   1. PR00545 (RETINOIDXR)
      219 - 232
      PRINTS
      PR00545 (RETINOIDXR)
      379 - 397
      PRINTS
      PR00545 (RETINOIDXR)
      420 - 439
      PRINTS
      PR00545 (RETINOIDXR)
3. IPR013088
   Zinc finger, NHR/GATA-type
   1. G3DSA:3.30.50.10
      149 - 213
      GENE3D
      G3DSA:3.30.50.10 (G3DSA:3.30.50.10)
4. IPR001628
   Zinc finger, nuclear hormone receptor-type
   1. PR00047 (STROIDFINGER)
      151 - 167
      PRINTS
      PR00047 (STROIDFINGER)
      208 - 216
      PRINTS
      PR00047 (STROIDFINGER)
      200 - 208
      PRINTS
      PR00047 (STROIDFINGER)
      167 - 182
      PRINTS
      PR00047 (STROIDFINGER)
   2. PS00031 (NUCLEAR_RE...)
      151 - 177
      PROSITE patterns
      PS00031 (NUCLEAR_REC_DBD_1)
   3. PS51030 (NUCLEAR_RE...)
      148 - 223
      PROSITE profiles
      PS51030 (NUCLEAR_REC_DBD_2)
   4. PF00105 (zf-C4)
      150 - 218
      Pfam
      PF00105 (zf-C4)
   5. SM00399 (ZnF_C4)
      148 - 219
      SMART
      SM00399 (ZnF_C4)
5. IPR008946
   Nuclear hormone receptor, ligand-binding
   1. SSF48508 (Nuclear r...)
      218 - 254
      SUPERFAMILY
      SSF48508 (Nuclear receptor ligand-binding domain)
      289 - 485
      SUPERFAMILY
      SSF48508 (Nuclear receptor ligand-binding domain)
   2. G3DSA:1.10.56...
      214 - 486
      GENE3D
      G3DSA:1.10.565.10 (G3DSA:1.10.565.10)
6. IPR000536
   Nuclear hormone receptor, ligand-binding, core
   1. PF00104 (Hormone_recep)
      290 - 472
      Pfam
      PF00104 (Hormone_recep)
   2. SM00430 (HOLI)
      295 - 460
      SMART
      SM00430 (HOLI)

no IPR
Unintegrated signatures

1. PTHR24083 (NUCLEAR ...)
   148 - 489
   PANTHER
   PTHR24083 (NUCLEAR HORMONE RECEPTOR)
2. PTHR24083:SF41 (HEP...)
   148 - 489
   PANTHER
   PTHR24083:SF41 (HEPATOCYTE NUCLEAR FACTOR 4-ALPHA)
3. SSF57716 (Glucocort...)
   149 - 233
   SUPERFAMILY
   SSF57716 (Glucocorticoid receptor-like (DNA-binding domain))

### GO term prediction

#### Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0043401 steroid hormone mediated signaling pathway

#### Molecular Function

GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding

#### Cellular Component

GO:0005634 nucleus