Protein

## EMLSAP00000007448

Length
1,745 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   164 - 254
   - Alpha-2-macroglobulin, N-terminal (IPR002890)
   626 - 730
   - Alpha-2-macroglobulin, N-terminal 2 (IPR011625)
   913 - 994
   - Alpha-2-macroglobulin (IPR001599)
   1,169 - 1,482
   - Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930)
     - Alpha-macroglobulin complement component (IPR011626)
   1,564 - 1,668
   - Alpha-macroglobulin, receptor-binding (IPR009048)
2. Repeat
   842 - 881
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)

1 200 400 600 800 1000 1200 1400 1600 1745

### Detailed signature matches

1. IPR002890
   Alpha-2-macroglobulin, N-terminal
   1. PF01835 (A2M_N)
      164 - 254
      Pfam
      PF01835 (A2M_N)
2. IPR011625
   Alpha-2-macroglobulin, N-terminal 2
   1. PF07703 (A2M_N_2)
      626 - 730
      Pfam
      PF07703 (A2M_N_2)
3. IPR001599
   Alpha-2-macroglobulin
   1. PF00207 (A2M)
      913 - 994
      Pfam
      PF00207 (A2M)
4. IPR008930
   Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
   1. SSF48239 (Terpenoid...)
      1,169 - 1,482
      SUPERFAMILY
      SSF48239 (Terpenoid cyclases/Protein prenyltransferases)
5. IPR011626
   Alpha-macroglobulin complement component
   1. PF07678 (A2M_comp)
      1,219 - 1,481
      Pfam
      PF07678 (A2M_comp)
6. IPR009048
   Alpha-macroglobulin, receptor-binding
   1. PF07677 (A2M_recep)
      1,597 - 1,668
      Pfam
      PF07677 (A2M_recep)
   2. G3DSA:2.60.40...
      1,569 - 1,668
      GENE3D
      G3DSA:2.60.40.690 (G3DSA:2.60.40.690)
   3. SSF49410 (Alpha-mac...)
      1,564 - 1,667
      SUPERFAMILY
      SSF49410 (Alpha-macroglobulin receptor domain)
7. IPR002172
   Low-density lipoprotein (LDL) receptor class A repeat
   1. PS50068 (LDLRA_2)
      842 - 880
      PROSITE profiles
      PS50068 (LDLRA_2)
   2. SSF57424 (LDL recep...)
      845 - 879
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
   3. G3DSA:4.10.40...
      847 - 879
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
   4. SM00192 (LDLa)
      842 - 881
      SMART
      SM00192 (LDLa)

no IPR
Unintegrated signatures

1. G3DSA:1.50.10.20
   1,169 - 1,483
   GENE3D
   G3DSA:1.50.10.20 (G3DSA:1.50.10.20)
2. PTHR11412 (MACROGLO...)
   15 - 1,732
   PANTHER
   PTHR11412 (MACROGLOBULIN/COMPLEMENT)
3. PTHR11412:SF22 (UNC...)
   15 - 1,732
   PANTHER
   PTHR11412:SF22 (UNCHARACTERIZED)
4. TMhelix
   1,717 - 1,736
   TMHMM
   TMhelix (TMhelix)
   13 - 32
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding

#### Cellular Component

GO:0005576 extracellular region
GO:0005615 extracellular space