Protein

## EMLSAP00000001667

Length
836 amino acids

### Protein family membership

- Ribosomal RNA large subunit methyltransferase E (IPR015507)
  - AdoMet-dependent rRNA methyltransferase, Spb1 (IPR028589)

### Domains and repeats

1. Domain
   24 - 200
   - Ribosomal RNA methyltransferase FtsJ domain (IPR002877)
   231 - 381
   - Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 (IPR024576)
   592 - 815
   - Ribosomal RNA methyltransferase, Spb1, C-terminal (IPR012920)

1 100 200 300 400 500 600 700 836

### Detailed signature matches

1. IPR015507
   Ribosomal RNA large subunit methyltransferase E
   1. MF_01547 (RNA_methy...)
      4 - 202
      HAMAP
      MF_01547 (RNA_methyltr_E)
   2. PTHR10920 (RIBOSOMA...)
      2 - 826
      PANTHER
      PTHR10920 (RIBOSOMAL RNA METHYLTRANSFERASE)
2. IPR028589
   AdoMet-dependent rRNA methyltransferase, Spb1
   1. MF_03163 (RNA_methy...)
      1 - 830
      HAMAP
      MF_03163 (RNA_methyltr_E_SPB1)
   2. PTHR10920:SF13 (RRN...)
      2 - 826
      PANTHER
      PTHR10920:SF13 (RRNA METHYLTRANSFERASE 3)
3. IPR002877
   Ribosomal RNA methyltransferase FtsJ domain
   1. PF01728 (FtsJ)
      24 - 200
      Pfam
      PF01728 (FtsJ)
4. IPR024576
   Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381
   1. PF11861 (DUF3381)
      231 - 381
      Pfam
      PF11861 (DUF3381)
5. IPR012920
   Ribosomal RNA methyltransferase, Spb1, C-terminal
   1. PF07780 (Spb1_C)
      592 - 815
      Pfam
      PF07780 (Spb1_C)

no IPR
Unintegrated signatures

1. Coil
   317 - 381
   COILS
   Coil (Coil)
   719 - 747
   COILS
   Coil (Coil)
2. G3DSA:3.40.50...
   23 - 201
   GENE3D
   G3DSA:3.40.50.150 (G3DSA:3.40.50.150)
3. SSF53335 (S-adenosy...)
   5 - 211
   SUPERFAMILY
   SSF53335 (S-adenosyl-L-methionine-dependent methyltransferases)

### GO term prediction

#### Biological Process

GO:0001510 RNA methylation
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation

#### Molecular Function

GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity

#### Cellular Component

GO:0005634 nucleus