Protein

## EMLSAP00000005792

Length
1,494 amino acids

### Protein family membership

- Ras guanine nucleotide exchange factor (IPR008937)

### Domains and repeats

1. Domain
   103 - 325
   - Dbl homology (DH) domain (IPR000219)
   521 - 682
   - Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
   1,220 - 1,457
   - Guanine-nucleotide dissociation stimulator CDC25 (IPR001895)
2. Domain
   514 - 576
   - Ras guanine nucleotide exchange factor, domain (IPR023578)
   1,125 - 1,458
   - Ras guanine nucleotide exchange factor, domain (IPR023578)

1 200 400 600 800 1000 1200 1494

### Detailed signature matches

1. IPR008937
   Ras guanine nucleotide exchange factor
   1. PTHR23113 (GUANINE ...)
      17 - 1,486
      PANTHER
      PTHR23113 (GUANINE NUCLEOTIDE EXCHANGE FACTOR)
2. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      126 - 307
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      104 - 325
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      130 - 306
      Pfam
      PF00621 (RhoGEF)
   4. G3DSA:1.20.90...
      103 - 325
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
   5. PS50010 (DH_2)
      122 - 308
      PROSITE profiles
      PS50010 (DH_2)
3. IPR023578
   Ras guanine nucleotide exchange factor, domain
   1. SSF48366 (Ras GEF)
      1,125 - 1,458
      SUPERFAMILY
      SSF48366 (Ras GEF)
      514 - 576
      SUPERFAMILY
      SSF48366 (Ras GEF)
4. IPR000651
   Ras-like guanine nucleotide exchange factor, N-terminal
   1. PF00618 (RasGEF_N)
      525 - 585
      Pfam
      PF00618 (RasGEF_N)
   2. PS50212 (RASGEF_NTER)
      522 - 642
      PROSITE profiles
      PS50212 (RASGEF_NTER)
   3. SM00229 (RasGEFN)
      521 - 682
      SMART
      SM00229 (RasGEFN)
5. IPR001895
   Guanine-nucleotide dissociation stimulator CDC25
   1. PF00617 (RasGEF)
      1,225 - 1,406
      Pfam
      PF00617 (RasGEF)
   2. PS50009 (RASGEF_CAT)
      1,224 - 1,456
      PROSITE profiles
      PS50009 (RASGEF_CAT)
   3. G3DSA:1.10.84...
      1,226 - 1,445
      GENE3D
      G3DSA:1.10.840.10 (G3DSA:1.10.840.10)
   4. SM00147 (RasGEF)
      1,220 - 1,457
      SMART
      SM00147 (RasGEF)
6. IPR000048
   IQ motif, EF-hand binding site
   1. PS50096 (IQ)
      86 - 111
      PROSITE profiles
      PS50096 (IQ)
7. IPR019804
   Ras guanine-nucleotide exchange factor, conserved site
   1. PS00720 (RASGEF)
      1,373 - 1,403
      PROSITE patterns
      PS00720 (RASGEF)

no IPR
Unintegrated signatures

1. Coil
   28 - 56
   COILS
   Coil (Coil)
   288 - 319
   COILS
   Coil (Coil)
2. G3DSA:1.20.87...
   495 - 591
   GENE3D
   G3DSA:1.20.870.10 (G3DSA:1.20.870.10)
   1,117 - 1,225
   GENE3D
   G3DSA:1.20.870.10 (G3DSA:1.20.870.10)
3. PTHR23113:SF51 (RAS...)
   17 - 1,486
   PANTHER
   PTHR23113:SF51 (RAS GTP EXCHANGE FACTOR)

### GO term prediction

#### Biological Process

GO:0007264 small GTPase mediated signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction

#### Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

#### Cellular Component

GO:0005622 intracellular