Protein

## EMLSAP00000008525

Length
792 amino acids

### Protein family membership

- Ras GTPase-activating protein 1 (IPR028554)

### Domains and repeats

1. Domain
   28 - 123
   - SH2 domain (IPR000980)
   192 - 290
   - SH2 domain (IPR000980)
   419 - 761
   - Rho GTPase activation protein (IPR008936)
     - Ras GTPase-activating protein (IPR001936)
2. Domain
   130 - 192
   - Src homology-3 domain (IPR001452)
   302 - 451
   - C2 domain (IPR000008)

1 100 200 300 400 500 600 700 792

### Detailed signature matches

1. IPR028554
   Ras GTPase-activating protein 1
   1. PTHR10194:SF19 (RAS...)
      24 - 764
      PANTHER
      PTHR10194:SF19 (RAS GTPASE-ACTIVATING PROTEIN 1)
2. IPR000980
   SH2 domain
   1. PF00017 (SH2)
      32 - 107
      Pfam
      PF00017 (SH2)
      202 - 275
      Pfam
      PF00017 (SH2)
   2. PR00401 (SH2DOMAIN)
      53 - 63
      PRINTS
      PR00401 (SH2DOMAIN)
      264 - 278
      PRINTS
      PR00401 (SH2DOMAIN)
      32 - 46
      PRINTS
      PR00401 (SH2DOMAIN)
      233 - 244
      PRINTS
      PR00401 (SH2DOMAIN)
   3. PS50001 (SH2)
      32 - 123
      PROSITE profiles
      PS50001 (SH2)
      202 - 290
      PROSITE profiles
      PS50001 (SH2)
   4. G3DSA:3.30.50...
      192 - 284
      GENE3D
      G3DSA:3.30.505.10 (G3DSA:3.30.505.10)
      28 - 123
      GENE3D
      G3DSA:3.30.505.10 (G3DSA:3.30.505.10)
   5. SM00252 (SH2)
      30 - 113
      SMART
      SM00252 (SH2)
      200 - 281
      SMART
      SM00252 (SH2)
3. IPR001452
   Src homology-3 domain
   1. SM00326 (SH3)
      133 - 191
      SMART
      SM00326 (SH3)
   2. PF00018 (SH3_1)
      136 - 182
      Pfam
      PF00018 (SH3_1)
   3. PS50002 (SH3)
      130 - 192
      PROSITE profiles
      PS50002 (SH3)
4. IPR000008
   C2 domain
   1. PF00168 (C2)
      324 - 395
      Pfam
      PF00168 (C2)
   2. SSF49562 (C2 domain...)
      329 - 451
      SUPERFAMILY
      SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
   3. SM00239 (C2)
      302 - 412
      SMART
      SM00239 (C2)
5. IPR008936
   Rho GTPase activation protein
   1. SSF48350 (GTPase ac...)
      440 - 733
      SUPERFAMILY
      SSF48350 (GTPase activation domain, GAP)
6. IPR001936
   Ras GTPase-activating protein
   1. PF00616 (RasGAP)
      490 - 663
      Pfam
      PF00616 (RasGAP)
   2. PS50018 (RAS_GTPASE...)
      469 - 663
      PROSITE profiles
      PS50018 (RAS_GTPASE_ACTIV_2)
   3. SM00323 (RasGAP)
      419 - 761
      SMART
      SM00323 (RasGAP)
   4. G3DSA:1.10.50...
      489 - 700
      GENE3D
      G3DSA:1.10.506.10 (G3DSA:1.10.506.10)
7. IPR023152
   Ras GTPase-activating protein, conserved site
   1. PS00509 (RAS_GTPASE...)
      619 - 633
      PROSITE patterns
      PS00509 (RAS_GTPASE_ACTIV_1)

no IPR
Unintegrated signatures

1. G3DSA:2.30.30.40
   124 - 182
   GENE3D
   G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
2. G3DSA:2.60.40...
   332 - 433
   GENE3D
   G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
3. PTHR10194 (RAS GTPA...)
   24 - 764
   PANTHER
   PTHR10194 (RAS GTPASE-ACTIVATING PROTEINS)
4. SSF55550 (SH2 domain)
   164 - 285
   SUPERFAMILY
   SSF55550 (SH2 domain)
   29 - 145
   SUPERFAMILY
   SSF55550 (SH2 domain)

### GO term prediction

#### Biological Process

GO:0007165 signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0046580 negative regulation of Ras protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction

#### Molecular Function

GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005515 protein binding

#### Cellular Component

GO:0005622 intracellular