Protein

## EMLSAP00000007184

Length
1,242 amino acids

### Protein family membership

- Ku70 (IPR006165)

- Protein arginine N-methyltransferase (IPR025799)

### Domains and repeats

1. Domain
   41 - 216
   - von Willebrand factor, type A (IPR002035)
   248 - 295
   - Ku70, bridge and pillars domain (IPR027388)
   412 - 539
   - Ku70/Ku80 C-terminal arm (IPR005160)
   549 - 582
   - SAP domain (IPR003034)
2. Domain
   42 - 222
   - Ku70/Ku80, N-terminal alpha/beta (IPR005161)
   229 - 425
   - Ku70/Ku80 beta-barrel domain (IPR006164)
3. Domain
   223 - 508
   - SPOC like C-terminal domain (IPR016194)

1 200 400 600 800 1000 1242

### Detailed signature matches

1. IPR006165
   Ku70
   1. TIGR00578
      23 - 582
      UNKNOWN
      TIGR00578 (TIGR00578)
2. IPR025799
   Protein arginine N-methyltransferase
   1. PTHR11006 (PROTEIN ...)
      663 - 1,065
      PANTHER
      PTHR11006 (PROTEIN ARGININE N-METHYLTRANSFERASE)
   2. PS51678 (SAM_MT_PRMT)
      734 - 1,038
      PROSITE profiles
      PS51678 (SAM_MT_PRMT)
   3. PF05185 (PRMT5)
      752 - 1,023
      Pfam
      PF05185 (PRMT5)
3. IPR002035
   von Willebrand factor, type A
   1. G3DSA:3.40.50...
      41 - 216
      GENE3D
      G3DSA:3.40.50.410 (G3DSA:3.40.50.410)
4. IPR005161
   Ku70/Ku80, N-terminal alpha/beta
   1. PF03731 (Ku_N)
      42 - 222
      Pfam
      PF03731 (Ku_N)
5. IPR016194
   SPOC like C-terminal domain
   1. G3DSA:2.40.29...
      296 - 410
      GENE3D
      G3DSA:2.40.290.10 (G3DSA:2.40.290.10)
   2. SSF100939 (SPOC dom...)
      223 - 508
      SUPERFAMILY
      SSF100939 (SPOC domain-like)
6. IPR006164
   Ku70/Ku80 beta-barrel domain
   1. PF02735 (Ku)
      229 - 419
      Pfam
      PF02735 (Ku)
   2. SM00559 (Ku78)
      276 - 425
      SMART
      SM00559 (Ku78)
7. IPR027388
   Ku70, bridge and pillars domain
   1. G3DSA:4.10.97...
      248 - 295
      GENE3D
      G3DSA:4.10.970.10 (G3DSA:4.10.970.10)
8. IPR005160
   Ku70/Ku80 C-terminal arm
   1. PF03730 (Ku_C)
      446 - 539
      Pfam
      PF03730 (Ku_C)
   2. G3DSA:1.10.16...
      412 - 507
      GENE3D
      G3DSA:1.10.1600.10 (G3DSA:1.10.1600.10)
9. IPR003034
   SAP domain
   1. G3DSA:1.10.72...
      549 - 582
      GENE3D
      G3DSA:1.10.720.30 (G3DSA:1.10.720.30)

no IPR
Unintegrated signatures

1. G3DSA:2.70.16...
   877 - 1,058
   GENE3D
   G3DSA:2.70.160.11 (G3DSA:2.70.160.11)
2. G3DSA:3.40.50...
   728 - 875
   GENE3D
   G3DSA:3.40.50.150 (G3DSA:3.40.50.150)
3. PTHR11006:SF10 (PRO...)
   663 - 1,065
   PANTHER
   PTHR11006:SF10 (PROTEIN ARGININE N-METHYLTRANSFERASE 1)
4. SSF53300 (vWA-like)
   25 - 202
   SUPERFAMILY
   SSF53300 (vWA-like)
5. SSF53335 (S-adenosy...)
   740 - 1,043
   SUPERFAMILY
   SSF53335 (S-adenosyl-L-methionine-dependent methyltransferases)

### GO term prediction

#### Biological Process

GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006479 protein methylation

#### Molecular Function

GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0008168 methyltransferase activity
GO:0042162 telomeric DNA binding

#### Cellular Component

GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex