Protein

## EMLSAP00000007768

Length
816 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   52 - 114
   - NAD(P)-binding domain (IPR016040)
   453 - 570
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
   605 - 664
   - Zinc finger, FYVE-related (IPR017455)
   707 - 816
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
2. Domain
   248 - 454
   - Dbl homology (DH) domain (IPR000219)
   597 - 667
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
     - FYVE zinc finger (IPR000306)

1 100 200 300 400 500 600 700 816

### Detailed signature matches

1. IPR016040
   NAD(P)-binding domain
   1. G3DSA:3.40.50...
      52 - 114
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
2. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      256 - 436
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      250 - 454
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      256 - 435
      Pfam
      PF00621 (RhoGEF)
   4. G3DSA:1.20.90...
      248 - 452
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
   5. PS50010 (DH_2)
      252 - 437
      PROSITE profiles
      PS50010 (DH_2)
3. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      707 - 813
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
      453 - 568
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
4. IPR001849
   Pleckstrin homology domain
   1. PF00169 (PH)
      467 - 566
      Pfam
      PF00169 (PH)
      712 - 813
      Pfam
      PF00169 (PH)
   2. SM00233 (PH)
      466 - 570
      SMART
      SM00233 (PH)
      709 - 816
      SMART
      SM00233 (PH)
   3. PS50003 (PH_DOMAIN)
      708 - 814
      PROSITE profiles
      PS50003 (PH_DOMAIN)
      465 - 568
      PROSITE profiles
      PS50003 (PH_DOMAIN)
5. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10
      601 - 667
      GENE3D
      G3DSA:3.30.40.10 (G3DSA:3.30.40.10)
6. IPR000306
   FYVE zinc finger
   1. SM00064 (FYVE)
      597 - 665
      SMART
      SM00064 (FYVE)
   2. PF01363 (FYVE)
      601 - 664
      Pfam
      PF01363 (FYVE)
7. IPR017455
   Zinc finger, FYVE-related
   1. PS50178 (ZF_FYVE)
      605 - 664
      PROSITE profiles
      PS50178 (ZF_FYVE)

no IPR
Unintegrated signatures

1. PTHR12673 (FACIOGEN...)
   152 - 812
   PANTHER
   PTHR12673 (FACIOGENITAL DYSPLASIA PROTEIN)
2. SSF50729 (PH domain...)
   444 - 569
   SUPERFAMILY
   SSF50729 (PH domain-like)
   623 - 813
   SUPERFAMILY
   SSF50729 (PH domain-like)
3. SSF51735 (NAD(P)-bi...)
   2 - 107
   SUPERFAMILY
   SSF51735 (NAD(P)-binding Rossmann-fold domains)
4. TMhelix
   36 - 58
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0035023 regulation of Rho protein signal transduction

#### Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding

#### Cellular Component

None predicted.