Protein

## EMLSAP00000008868

Length
923 amino acids

### Protein family membership

- Adaptor protein complex AP-2, alpha subunit (IPR017104)

### Domains and repeats

1. Domain
   6 - 620
   - Armadillo-type fold (IPR016024)
     - Armadillo-like helical (IPR011989)
   691 - 804
   - Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (IPR008152)
   810 - 923
   - Coatomer/calthrin adaptor appendage, C-terminal subdomain (IPR009028)
     - Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain (IPR015873)
       - Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain (IPR003164)
2. Domain
   31 - 588
   - Clathrin/coatomer adaptor, adaptin-like, N-terminal (IPR002553)
   685 - 810
   - Coatomer/clathrin adaptor appendage, Ig-like subdomain (IPR013041)
     - Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain (IPR013038)

1 100 200 300 400 500 600 700 800 923

### Detailed signature matches

1. IPR017104
   Adaptor protein complex AP-2, alpha subunit
   1. PIRSF037091 (AP2_alpha)
      2 - 923
      PIRSF
      PIRSF037091 (AP2_alpha)
2. IPR016024
   Armadillo-type fold
   1. SSF48371 (ARM repeat)
      9 - 589
      SUPERFAMILY
      SSF48371 (ARM repeat)
3. IPR011989
   Armadillo-like helical
   1. G3DSA:1.25.10.10
      6 - 620
      GENE3D
      G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
4. IPR002553
   Clathrin/coatomer adaptor, adaptin-like, N-terminal
   1. PF01602 (Adaptin_N)
      31 - 588
      Pfam
      PF01602 (Adaptin_N)
5. IPR013041
   Coatomer/clathrin adaptor appendage, Ig-like subdomain
   1. SSF49348 (Clathrin ...)
      685 - 809
      SUPERFAMILY
      SSF49348 (Clathrin adaptor appendage domain)
6. IPR013038
   Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
   1. G3DSA:2.60.40...
      688 - 810
      GENE3D
      G3DSA:2.60.40.1030 (G3DSA:2.60.40.1030)
7. IPR008152
   Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
   1. PF02883 (Alpha_adap...)
      697 - 802
      Pfam
      PF02883 (Alpha_adaptinC2)
   2. SM00809 (Alpha_adap...)
      691 - 804
      SMART
      SM00809 (Alpha_adaptinC2)
8. IPR009028
   Coatomer/calthrin adaptor appendage, C-terminal subdomain
   1. SSF55711 (Subdomain...)
      810 - 923
      SUPERFAMILY
      SSF55711 (Subdomain of clathrin and coatomer appendage domain)
9. IPR015873
   Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
   1. G3DSA:3.30.31...
      811 - 923
      GENE3D
      G3DSA:3.30.310.30 (G3DSA:3.30.310.30)
10. IPR003164
    Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
    1. PF02296 (Alpha_adap...)
       810 - 917
       Pfam
       PF02296 (Alpha_adaptin_C)

no IPR
Unintegrated signatures

1. Coil
   23 - 44
   COILS
   Coil (Coil)
2. PTHR22780 (ADAPTIN,...)
   1 - 914
   PANTHER
   PTHR22780 (ADAPTIN, ALPHA/GAMMA/EPSILON)
3. PTHR22780:SF4 (ADAP...)
   1 - 914
   PANTHER
   PTHR22780:SF4 (ADAPTER-RELATED PROTEIN COMPLEX 2 ALPHA 1 SUBUNIT (ALPHA-ADAPTIN A))

### GO term prediction

#### Biological Process

GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport

#### Molecular Function

GO:0005488 binding
GO:0008565 protein transporter activity

#### Cellular Component

GO:0016020 membrane
GO:0030117 membrane coat
GO:0030131 clathrin adaptor complex