Protein

## EMLSAP00000012687

Length
488 amino acids

### Protein family membership

- Dihydrolipoamide dehydrogenase (IPR006258)

- FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR013027)

### Domains and repeats

1. Domain
   22 - 339
   - Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain (IPR023753)
2. Domain
   195 - 272
   - Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain (IPR001327)
   356 - 483
   - FAD/NAD-linked reductase, dimerisation domain (IPR016156)
     - Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (IPR004099)

1 50 100 150 200 250 300 350 400 450 488

### Detailed signature matches

1. IPR006258
   Dihydrolipoamide dehydrogenase
   1. TIGR01350
      21 - 486
      UNKNOWN
      TIGR01350 (TIGR01350)
2. IPR013027
   FAD-dependent pyridine nucleotide-disulphide oxidoreductase
   1. PR00368 (FADPNR)
      314 - 336
      PRINTS
      PR00368 (FADPNR)
      195 - 213
      PRINTS
      PR00368 (FADPNR)
      285 - 301
      PRINTS
      PR00368 (FADPNR)
      23 - 42
      PRINTS
      PR00368 (FADPNR)
      156 - 174
      PRINTS
      PR00368 (FADPNR)
3. IPR023753
   Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
   1. PF07992 (Pyr_redox_2)
      22 - 339
      Pfam
      PF07992 (Pyr_redox_2)
4. IPR001327
   Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
   1. PF00070 (Pyr_redox)
      195 - 272
      Pfam
      PF00070 (Pyr_redox)
5. IPR016156
   FAD/NAD-linked reductase, dimerisation domain
   1. SSF55424 (FAD/NAD-l...)
      365 - 483
      SUPERFAMILY
      SSF55424 (FAD/NAD-linked reductases, dimerisation (C-terminal) domain)
6. IPR004099
   Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
   1. PF02852 (Pyr_redox_dim)
      368 - 476
      Pfam
      PF02852 (Pyr_redox_dim)
   2. G3DSA:3.30.39...
      356 - 479
      GENE3D
      G3DSA:3.30.390.30 (G3DSA:3.30.390.30)
7. IPR012999
   Pyridine nucleotide-disulphide oxidoreductase, class I, active site
   1. PS00076 (PYRIDINE_R...)
      56 - 66
      PROSITE patterns
      PS00076 (PYRIDINE_REDOX_1)

no IPR
Unintegrated signatures

1. G3DSA:3.50.50.60
   20 - 160
   GENE3D
   G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
   161 - 355
   GENE3D
   G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
2. PR00411 (PNDRDTASEI)
   55 - 70
   PRINTS
   PR00411 (PNDRDTASEI)
   22 - 44
   PRINTS
   PR00411 (PNDRDTASEI)
   329 - 336
   PRINTS
   PR00411 (PNDRDTASEI)
   451 - 471
   PRINTS
   PR00411 (PNDRDTASEI)
   195 - 220
   PRINTS
   PR00411 (PNDRDTASEI)
   286 - 300
   PRINTS
   PR00411 (PNDRDTASEI)
   364 - 385
   PRINTS
   PR00411 (PNDRDTASEI)
   429 - 444
   PRINTS
   PR00411 (PNDRDTASEI)
   159 - 168
   PRINTS
   PR00411 (PNDRDTASEI)
3. PTHR22912 (DISULFID...)
   1 - 478
   PANTHER
   PTHR22912 (DISULFIDE OXIDOREDUCTASE)
4. PTHR22912:SF20 (DIH...)
   1 - 478
   PANTHER
   PTHR22912:SF20 (DIHYDROLIPOAMIDE DEHYDROGENASE-RELATED)
5. SSF51905 (FAD/NAD(P...)
   19 - 358
   SUPERFAMILY
   SSF51905 (FAD/NAD(P)-binding domain)

### GO term prediction

#### Biological Process

GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding

#### Cellular Component

None predicted.