Protein

## EMLSAP00000008083

Length
1,241 amino acids

### Protein family membership

- Aconitase/isopropylmalate dehydratase (IPR015937)
  - Aconitase, mitochondrial-like (IPR006248)

### Domains and repeats

1. Domain
   43 - 176
   - Peptidase S24/S26, beta-ribbon domain (IPR028360)
2. Domain
   44 - 176
   - Peptidase S24/S26A/S26B/S26C (IPR015927)
   223 - 259
   - WD40-repeat-containing domain (IPR017986)
   319 - 518
   - WD40-repeat-containing domain (IPR017986)
   618 - 1,135
   - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (IPR001030)
   1,172 - 1,236
   - Aconitase/3-isopropylmalate dehydratase, swivel (IPR015928)
3. Domain
   74 - 130
   - Peptidase S24/S26A/S26B (IPR019759)
   616 - 812
   - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (IPR015931)
   813 - 926
   - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (IPR015932)
   928 - 1,098
   - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (IPR015931)

1 200 400 600 800 1000 1241

### Detailed signature matches

1. IPR015937
   Aconitase/isopropylmalate dehydratase
   1. PTHR11670 (ACONITASE)
      586 - 1,172
      PANTHER
      PTHR11670 (ACONITASE)
2. IPR006248
   Aconitase, mitochondrial-like
   1. TIGR01340
      628 - 1,172
      UNKNOWN
      TIGR01340 (TIGR01340)
   2. PTHR11670:SF5 (ACON...)
      586 - 1,172
      PANTHER
      PTHR11670:SF5 (ACONITASE, MITOCHONDRIAL)
3. IPR028360
   Peptidase S24/S26, beta-ribbon domain
   1. G3DSA:2.10.10...
      43 - 176
      GENE3D
      G3DSA:2.10.109.10 (G3DSA:2.10.109.10)
4. IPR015927
   Peptidase S24/S26A/S26B/S26C
   1. SSF51306 (LexA/Sign...)
      44 - 176
      SUPERFAMILY
      SSF51306 (LexA/Signal peptidase)
5. IPR019759
   Peptidase S24/S26A/S26B
   1. PF00717 (Peptidase_S24)
      74 - 130
      Pfam
      PF00717 (Peptidase_S24)
6. IPR017986
   WD40-repeat-containing domain
   1. SSF50978 (WD40 repe...)
      223 - 259
      SUPERFAMILY
      SSF50978 (WD40 repeat-like)
      319 - 518
      SUPERFAMILY
      SSF50978 (WD40 repeat-like)
7. IPR015931
   Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
   1. G3DSA:3.30.49...
      616 - 812
      GENE3D
      G3DSA:3.30.499.10 (G3DSA:3.30.499.10)
      928 - 1,098
      GENE3D
      G3DSA:3.30.499.10 (G3DSA:3.30.499.10)
8. IPR001030
   Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
   1. PR00415 (ACONITASE)
      856 - 869
      PRINTS
      PR00415 (ACONITASE)
      723 - 736
      PRINTS
      PR00415 (ACONITASE)
      931 - 945
      PRINTS
      PR00415 (ACONITASE)
      780 - 795
      PRINTS
      PR00415 (ACONITASE)
      746 - 754
      PRINTS
      PR00415 (ACONITASE)
      766 - 779
      PRINTS
      PR00415 (ACONITASE)
      965 - 976
      PRINTS
      PR00415 (ACONITASE)
      1,024 - 1,037
      PRINTS
      PR00415 (ACONITASE)
      842 - 855
      PRINTS
      PR00415 (ACONITASE)
   2. PF00330 (Aconitase)
      647 - 1,087
      Pfam
      PF00330 (Aconitase)
   3. SSF53732 (Aconitase...)
      618 - 1,135
      SUPERFAMILY
      SSF53732 (Aconitase iron-sulfur domain)
9. IPR015932
   Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
   1. G3DSA:3.40.10...
      813 - 926
      GENE3D
      G3DSA:3.40.1060.10 (G3DSA:3.40.1060.10)
10. IPR015928
    Aconitase/3-isopropylmalate dehydratase, swivel
    1. G3DSA:3.20.19.10
       1,172 - 1,236
       GENE3D
       G3DSA:3.20.19.10 (G3DSA:3.20.19.10)
11. IPR018136
    Aconitase family, 4Fe-4S cluster binding site
    1. PS00450 (ACONITASE_1)
       961 - 977
       PROSITE patterns
       PS00450 (ACONITASE_1)
    2. PS01244 (ACONITASE_2)
       1,024 - 1,037
       PROSITE patterns
       PS01244 (ACONITASE_2)

no IPR
Unintegrated signatures

1. TMhelix
   20 - 42
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process

#### Molecular Function

GO:0003994 aconitate hydratase activity
GO:0005515 protein binding
GO:0051539 4 iron, 4 sulfur cluster binding

#### Cellular Component

None predicted.