Protein

## EMLSAP00000009394

Length
1,031 amino acids

### Protein family membership

- Ubiquitin-activating enzyme, E1 (IPR018075)

- Ubiquitin/SUMO-activating enzyme E1 (IPR000011)

### Domains and repeats

1. Domain
   39 - 421
   - NAD(P)-binding domain (IPR016040)
     - Molybdenum cofactor biosynthesis, MoeB (IPR009036)
   432 - 929
   - NAD(P)-binding domain (IPR016040)
     - Molybdenum cofactor biosynthesis, MoeB (IPR009036)
2. Domain
   64 - 182
   - UBA/THIF-type NAD/FAD binding fold (IPR000594)
   456 - 594
   - UBA/THIF-type NAD/FAD binding fold (IPR000594)
   619 - 767
   - Ubiquitin-like 1 activating enzyme, catalytic cysteine domain (IPR023280)
   805 - 878
   - Ubiquitin-like 1 activating enzyme, catalytic cysteine domain (IPR023280)
3. Domain
   601 - 643
   - Ubiquitin-activating enzyme (IPR019572)
   911 - 1,022
   - Ubiquitin-activating enzyme e1, C-terminal (IPR018965)
4. Repeat
   741 - 792
   - Ubiquitin-activating enzyme repeat (IPR000127)
   838 - 904
   - Ubiquitin-activating enzyme repeat (IPR000127)

1 100 200 300 400 500 600 700 800 900 1031

### Detailed signature matches

1. IPR018075
   Ubiquitin-activating enzyme, E1
   1. TIGR01408
      41 - 1,013
      UNKNOWN
      TIGR01408 (TIGR01408)
2. IPR000011
   Ubiquitin/SUMO-activating enzyme E1
   1. PR01849 (UBIQUITINACT)
      178 - 205
      PRINTS
      PR01849 (UBIQUITINACT)
      485 - 508
      PRINTS
      PR01849 (UBIQUITINACT)
      532 - 557
      PRINTS
      PR01849 (UBIQUITINACT)
      686 - 713
      PRINTS
      PR01849 (UBIQUITINACT)
      68 - 92
      PRINTS
      PR01849 (UBIQUITINACT)
3. IPR016040
   NAD(P)-binding domain
   1. G3DSA:3.40.50...
      436 - 618
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
      881 - 910
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
      285 - 420
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
      39 - 245
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
4. IPR009036
   Molybdenum cofactor biosynthesis, MoeB
   1. SSF69572 (Activatin...)
      432 - 929
      SUPERFAMILY
      SSF69572 (Activating enzymes of the ubiquitin-like proteins)
      40 - 421
      SUPERFAMILY
      SSF69572 (Activating enzymes of the ubiquitin-like proteins)
5. IPR000594
   UBA/THIF-type NAD/FAD binding fold
   1. PF00899 (ThiF)
      456 - 594
      Pfam
      PF00899 (ThiF)
      64 - 182
      Pfam
      PF00899 (ThiF)
6. IPR019572
   Ubiquitin-activating enzyme
   1. PF10585 (UBA_e1_thi...)
      601 - 643
      Pfam
      PF10585 (UBA_e1_thiolCys)
7. IPR023280
   Ubiquitin-like 1 activating enzyme, catalytic cysteine domain
   1. G3DSA:1.10.32...
      619 - 767
      GENE3D
      G3DSA:1.10.3240.10 (G3DSA:1.10.3240.10)
      805 - 878
      GENE3D
      G3DSA:1.10.3240.10 (G3DSA:1.10.3240.10)
8. IPR018965
   Ubiquitin-activating enzyme e1, C-terminal
   1. PF09358 (UBA_e1_C)
      911 - 1,013
      Pfam
      PF09358 (UBA_e1_C)
   2. SM00985 (UBA_e1_C)
      911 - 1,022
      SMART
      SM00985 (UBA_e1_C)
9. IPR000127
   Ubiquitin-activating enzyme repeat
   1. PF02134 (UBACT)
      838 - 904
      Pfam
      PF02134 (UBACT)
      741 - 792
      Pfam
      PF02134 (UBACT)
10. IPR018074
    Ubiquitin-activating enzyme, E1, active site
    1. PS00536 (UBIQUITIN_...)
       398 - 406
       PROSITE patterns
       PS00536 (UBIQUITIN_ACTIVAT_1)

no IPR
Unintegrated signatures

1. PTHR10953 (UBIQUITI...)
   27 - 1,027
   PANTHER
   PTHR10953 (UBIQUITIN-ACTIVATING ENZYME E1)
2. PTHR10953:SF4 (UBIQ...)
   27 - 1,027
   PANTHER
   PTHR10953:SF4 (UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1 (UBIQUITIN-ACTIVATING ENZYME E1))

### GO term prediction

#### Biological Process

GO:0006464 cellular protein modification process

#### Molecular Function

GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008641 small protein activating enzyme activity

#### Cellular Component

None predicted.