Protein

## EMLSAP00000008585

Length
703 amino acids

### Protein family membership

- Ras guanine nucleotide exchange factor (IPR008937)

### Domains and repeats

1. Domain
   81 - 212
   - Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
   221 - 491
   - Guanine-nucleotide dissociation stimulator CDC25 (IPR001895)
2. Domain
   82 - 367
   - Ras guanine nucleotide exchange factor, domain (IPR023578)
   398 - 506
   - Ras guanine nucleotide exchange factor, domain (IPR023578)

1 100 200 300 400 500 600 703

### Detailed signature matches

1. IPR008937
   Ras guanine nucleotide exchange factor
   1. PTHR23113 (GUANINE ...)
      8 - 522
      PANTHER
      PTHR23113 (GUANINE NUCLEOTIDE EXCHANGE FACTOR)
2. IPR000651
   Ras-like guanine nucleotide exchange factor, N-terminal
   1. PF00618 (RasGEF_N)
      86 - 185
      Pfam
      PF00618 (RasGEF_N)
   2. PS50212 (RASGEF_NTER)
      82 - 212
      PROSITE profiles
      PS50212 (RASGEF_NTER)
   3. SM00229 (RasGEFN)
      81 - 212
      SMART
      SM00229 (RasGEFN)
3. IPR023578
   Ras guanine nucleotide exchange factor, domain
   1. SSF48366 (Ras GEF)
      82 - 367
      SUPERFAMILY
      SSF48366 (Ras GEF)
      398 - 506
      SUPERFAMILY
      SSF48366 (Ras GEF)
4. IPR001895
   Guanine-nucleotide dissociation stimulator CDC25
   1. PF00617 (RasGEF)
      243 - 439
      Pfam
      PF00617 (RasGEF)
   2. PS50009 (RASGEF_CAT)
      225 - 490
      PROSITE profiles
      PS50009 (RASGEF_CAT)
   3. G3DSA:1.10.84...
      243 - 479
      GENE3D
      G3DSA:1.10.840.10 (G3DSA:1.10.840.10)
   4. SM00147 (RasGEF)
      221 - 491
      SMART
      SM00147 (RasGEF)
5. IPR019804
   Ras guanine-nucleotide exchange factor, conserved site
   1. PS00720 (RASGEF)
      405 - 436
      PROSITE patterns
      PS00720 (RASGEF)

no IPR
Unintegrated signatures

1. G3DSA:1.20.87...
   82 - 226
   GENE3D
   G3DSA:1.20.870.10 (G3DSA:1.20.870.10)
2. G3DSA:3.10.20.90
   630 - 663
   GENE3D
   G3DSA:3.10.20.90 (G3DSA:3.10.20.90)
3. PTHR23113:SF31 (RAL...)
   8 - 522
   PANTHER
   PTHR23113:SF31 (RAL GUANINE NUCLEOTIDE EXCHANGE FACTOR, INSECT)
4. SSF54236 (Ubiquitin...)
   613 - 660
   SUPERFAMILY
   SSF54236 (Ubiquitin-like)

### GO term prediction

#### Biological Process

GO:0007264 small GTPase mediated signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction

#### Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity

#### Cellular Component

GO:0005622 intracellular