Protein

## EMLSAP00000007472

Length
426 amino acids

### Protein family membership

- Neurotransmitter-gated ion-channel (IPR006201)

### Domains and repeats

1. Domain
   17 - 63
   - Neurotransmitter-gated ion-channel ligand-binding (IPR006202)
   67 - 124
   - Neurotransmitter-gated ion-channel ligand-binding (IPR006202)
2. Domain
   124 - 425
   - Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)
3. Domain
   124 - 229
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)
   375 - 423
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)

1 50 100 150 200 250 300 350 400 426

### Detailed signature matches

1. IPR006201
   Neurotransmitter-gated ion-channel
   1. PTHR18945 (NEUROTRA...)
      9 - 419
      PANTHER
      PTHR18945 (NEUROTRANSMITTER GATED ION CHANNEL)
2. IPR006202
   Neurotransmitter-gated ion-channel ligand-binding
   1. PF02931 (Neur_chan_LBD)
      75 - 124
      Pfam
      PF02931 (Neur_chan_LBD)
   2. SSF63712 (Nicotinic...)
      17 - 63
      SUPERFAMILY
      SSF63712 (Nicotinic receptor ligand binding domain-like)
      68 - 123
      SUPERFAMILY
      SSF63712 (Nicotinic receptor ligand binding domain-like)
   3. G3DSA:2.70.17...
      18 - 62
      GENE3D
      G3DSA:2.70.170.10 (G3DSA:2.70.170.10)
      67 - 123
      GENE3D
      G3DSA:2.70.170.10 (G3DSA:2.70.170.10)
3. IPR027361
   Nicotinic acetylcholine-gated receptor, transmembrane domain
   1. G3DSA:1.20.12...
      124 - 229
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
      375 - 423
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
4. IPR006029
   Neurotransmitter-gated ion-channel transmembrane domain
   1. SSF90112 (Neurotran...)
      124 - 243
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
      299 - 425
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
   2. PF02932 (Neur_chan_...)
      131 - 415
      Pfam
      PF02932 (Neur_chan_memb)

no IPR
Unintegrated signatures

1. PTHR18945:SF70 (NIC...)
   9 - 419
   PANTHER
   PTHR18945:SF70 (NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA)
2. TMhelix
   187 - 209
   TMHMM
   TMhelix (TMhelix)
   402 - 424
   TMHMM
   TMhelix (TMhelix)
   126 - 148
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006810 transport
GO:0006811 ion transport

#### Molecular Function

GO:0005230 extracellular ligand-gated ion channel activity

#### Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane