Protein

## EMLSAP00000008901

Length
1,963 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   14 - 377
   - RNA polymerase Rpb1, domain 1 (IPR007080)
   379 - 542
   - RNA polymerase, alpha subunit (IPR000722)
   547 - 715
   - RNA polymerase Rpb1, domain 3 (IPR007066)
   853 - 1,449
   - RNA polymerase Rpb1, domain 5 (IPR007081)
2. Domain
   269 - 572
   - RNA polymerase, N-terminal (IPR006592)
   743 - 846
   - RNA polymerase Rpb1, domain 4 (IPR007083)
   919 - 1,100
   - RNA polymerase Rpb1, domain 6 (IPR007075)
   1,187 - 1,321
   - RNA polymerase Rpb1, domain 7 (IPR007073)
3. Repeat
   1,628 - 1,638
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,730 - 1,744
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,759 - 1,772
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,787 - 1,799
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,814 - 1,827
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,829 - 1,870
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,895 - 1,908
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
4. Repeat
   1,660 - 1,730
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,744 - 1,758
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,801 - 1,814
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,870 - 1,876
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)
   1,908 - 1,914
   - RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)

1 200 400 600 800 1000 1200 1400 1600 1800 1963

### Detailed signature matches

1. IPR007080
   RNA polymerase Rpb1, domain 1
   1. PF04997 (RNA_pol_Rp...)
      14 - 377
      Pfam
      PF04997 (RNA_pol_Rpb1_1)
2. IPR006592
   RNA polymerase, N-terminal
   1. SM00663 (RPOLA_N)
      269 - 572
      SMART
      SM00663 (RPOLA_N)
3. IPR000722
   RNA polymerase, alpha subunit
   1. PF00623 (RNA_pol_Rp...)
      379 - 542
      Pfam
      PF00623 (RNA_pol_Rpb1_2)
4. IPR007066
   RNA polymerase Rpb1, domain 3
   1. PF04983 (RNA_pol_Rp...)
      547 - 715
      Pfam
      PF04983 (RNA_pol_Rpb1_3)
5. IPR007083
   RNA polymerase Rpb1, domain 4
   1. PF05000 (RNA_pol_Rp...)
      743 - 846
      Pfam
      PF05000 (RNA_pol_Rpb1_4)
6. IPR007081
   RNA polymerase Rpb1, domain 5
   1. PF04998 (RNA_pol_Rp...)
      853 - 1,449
      Pfam
      PF04998 (RNA_pol_Rpb1_5)
7. IPR007075
   RNA polymerase Rpb1, domain 6
   1. PF04992 (RNA_pol_Rp...)
      919 - 1,100
      Pfam
      PF04992 (RNA_pol_Rpb1_6)
8. IPR007073
   RNA polymerase Rpb1, domain 7
   1. PF04990 (RNA_pol_Rp...)
      1,187 - 1,321
      Pfam
      PF04990 (RNA_pol_Rpb1_7)
9. IPR000684
   RNA polymerase II, heptapeptide repeat, eukaryotic
   1. PS00115 (RNA_POL_II...)
      1,765 - 1,771
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,908 - 1,914
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,681 - 1,687
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,702 - 1,708
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,870 - 1,876
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,723 - 1,729
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,751 - 1,757
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,737 - 1,743
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,730 - 1,736
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,709 - 1,715
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,807 - 1,813
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,835 - 1,841
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,667 - 1,673
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,842 - 1,848
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,856 - 1,862
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,716 - 1,722
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,688 - 1,694
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,744 - 1,750
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,660 - 1,666
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,901 - 1,907
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,814 - 1,820
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,674 - 1,680
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,821 - 1,827
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,849 - 1,855
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
      1,695 - 1,701
      PROSITE patterns
      PS00115 (RNA_POL_II_REPEAT)
   2. PF05001 (RNA_pol_Rp...)
      1,628 - 1,638
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,731 - 1,744
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,675 - 1,688
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,759 - 1,772
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,829 - 1,842
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,745 - 1,758
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,703 - 1,716
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,895 - 1,908
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,682 - 1,695
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,661 - 1,674
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,696 - 1,709
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,836 - 1,849
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,815 - 1,827
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,843 - 1,856
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,710 - 1,723
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,850 - 1,863
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,801 - 1,814
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,857 - 1,870
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,689 - 1,702
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,717 - 1,730
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,668 - 1,681
      Pfam
      PF05001 (RNA_pol_Rpb1_R)
      1,787 - 1,799
      Pfam
      PF05001 (RNA_pol_Rpb1_R)

no IPR
Unintegrated signatures

1. G3DSA:2.40.40.20
   475 - 543
   GENE3D
   G3DSA:2.40.40.20 (G3DSA:2.40.40.20)
   384 - 411
   GENE3D
   G3DSA:2.40.40.20 (G3DSA:2.40.40.20)
2. G3DSA:3.30.14...
   412 - 473
   GENE3D
   G3DSA:3.30.1490.180 (G3DSA:3.30.1490.180)
3. PR01217 (PRICHEXTENSN)
   1,703 - 1,720
   PRINTS
   PR01217 (PRICHEXTENSN)
   1,624 - 1,640
   PRINTS
   PR01217 (PRICHEXTENSN)
   1,686 - 1,702
   PRINTS
   PR01217 (PRICHEXTENSN)
   1,721 - 1,746
   PRINTS
   PR01217 (PRICHEXTENSN)
   1,665 - 1,686
   PRINTS
   PR01217 (PRICHEXTENSN)
4. PTHR19376 (DNA-DIRE...)
   3 - 1,546
   PANTHER
   PTHR19376 (DNA-DIRECTED RNA POLYMERASE)
5. PTHR19376:SF14 (DNA...)
   3 - 1,546
   PANTHER
   PTHR19376:SF14 (DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT)
6. SSF64484 (beta and ...)
   10 - 71
   SUPERFAMILY
   SSF64484 (beta and beta-prime subunits of DNA dependent RNA-polymerase)
   106 - 1,501
   SUPERFAMILY
   SSF64484 (beta and beta-prime subunits of DNA dependent RNA-polymerase)

### GO term prediction

#### Biological Process

GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter

#### Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity

#### Cellular Component

GO:0005665 DNA-directed RNA polymerase II, core complex