Protein

## EMLSAP00000006362

Length
440 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   47 - 432
   - NAD(P)-binding domain (IPR016040)
     - Molybdenum cofactor biosynthesis, MoeB (IPR009036)
2. Domain
   48 - 191
   - UBA/THIF-type NAD/FAD binding fold (IPR000594)
   197 - 240
   - Ubiquitin-activating enzyme (IPR019572)
   344 - 438
   - E2 binding (IPR014929)
3. Domain
   217 - 287
   - Ubiquitin activating enzyme, alpha domain (IPR023318)
4. Repeat
   249 - 312
   - Ubiquitin-activating enzyme repeat (IPR000127)

1 50 100 150 200 250 300 350 400 440

### Detailed signature matches

1. IPR000594
   UBA/THIF-type NAD/FAD binding fold
   1. PF00899 (ThiF)
      48 - 191
      Pfam
      PF00899 (ThiF)
2. IPR016040
   NAD(P)-binding domain
   1. G3DSA:3.40.50...
      48 - 216
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
      289 - 343
      GENE3D
      G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
3. IPR009036
   Molybdenum cofactor biosynthesis, MoeB
   1. SSF69572 (Activatin...)
      47 - 432
      SUPERFAMILY
      SSF69572 (Activating enzymes of the ubiquitin-like proteins)
4. IPR019572
   Ubiquitin-activating enzyme
   1. PF10585 (UBA_e1_thi...)
      197 - 240
      Pfam
      PF10585 (UBA_e1_thiolCys)
5. IPR023318
   Ubiquitin activating enzyme, alpha domain
   1. G3DSA:1.10.10...
      217 - 287
      GENE3D
      G3DSA:1.10.10.520 (G3DSA:1.10.10.520)
6. IPR014929
   E2 binding
   1. G3DSA:3.10.20...
      344 - 398
      GENE3D
      G3DSA:3.10.20.260 (G3DSA:3.10.20.260)
   2. PF08825 (E2_bind)
      352 - 438
      Pfam
      PF08825 (E2_bind)
7. IPR000127
   Ubiquitin-activating enzyme repeat
   1. PF02134 (UBACT)
      249 - 312
      Pfam
      PF02134 (UBACT)
8. IPR018074
   Ubiquitin-activating enzyme, E1, active site
   1. PS00865 (UBIQUITIN_...)
      215 - 223
      PROSITE patterns
      PS00865 (UBIQUITIN_ACTIVAT_2)

no IPR
Unintegrated signatures

1. PTHR10953 (UBIQUITI...)
   12 - 439
   PANTHER
   PTHR10953 (UBIQUITIN-ACTIVATING ENZYME E1)
2. PTHR10953:SF6 (UBIQ...)
   12 - 439
   PANTHER
   PTHR10953:SF6 (UBIQUITIN-ACTIVATING ENZYME E1C (NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT))

### GO term prediction

#### Biological Process

GO:0006464 cellular protein modification process
GO:0045116 protein neddylation

#### Molecular Function

GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008641 small protein activating enzyme activity
GO:0016881 acid-amino acid ligase activity

#### Cellular Component

None predicted.