Protein

## EMLSAP00000011633

Length
769 amino acids

### Protein family membership

- Fumarate lyase family (IPR000362)
  - Fumarate hydratase, class II (IPR005677)

### Domains and repeats

1. Domain
   1 - 104
   - Zinc finger, C2CH-type (IPR006612)
   306 - 648
   - Fumarase/histidase, N-terminal (IPR024083)
     - Fumarate lyase, N-terminal (IPR022761)
   714 - 768
   - Fumarase C, C-terminal (IPR018951)
2. Domain
   306 - 762
   - L-Aspartase-like (IPR008948)

1 100 200 300 400 500 600 700 769

### Detailed signature matches

1. IPR000362
   Fumarate lyase family
   1. PR00149 (FUMRATELYASE)
      623 - 639
      PRINTS
      PR00149 (FUMRATELYASE)
      577 - 604
      PRINTS
      PR00149 (FUMRATELYASE)
      486 - 504
      PRINTS
      PR00149 (FUMRATELYASE)
      440 - 458
      PRINTS
      PR00149 (FUMRATELYASE)
   2. PTHR11444 (ASPARTAT...)
      300 - 769
      PANTHER
      PTHR11444 (ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE)
2. IPR005677
   Fumarate hydratase, class II
   1. MF_00743 (FumaraseC)
      307 - 768
      HAMAP
      MF_00743 (FumaraseC)
   2. TIGR00979
      307 - 767
      UNKNOWN
      TIGR00979 (TIGR00979)
3. IPR006612
   Zinc finger, C2CH-type
   1. SM00980 (THAP)
      3 - 104
      SMART
      SM00980 (THAP)
   2. PS50950 (ZF_THAP)
      1 - 98
      PROSITE profiles
      PS50950 (ZF_THAP)
   3. PF05485 (THAP)
      4 - 99
      Pfam
      PF05485 (THAP)
4. IPR024083
   Fumarase/histidase, N-terminal
   1. G3DSA:1.10.27...
      306 - 444
      GENE3D
      G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
5. IPR008948
   L-Aspartase-like
   1. SSF48557 (L-asparta...)
      306 - 762
      SUPERFAMILY
      SSF48557 (L-aspartase-like)
6. IPR022761
   Fumarate lyase, N-terminal
   1. PF00206 (Lyase_1)
      315 - 648
      Pfam
      PF00206 (Lyase_1)
7. IPR018951
   Fumarase C, C-terminal
   1. PF10415 (FumaraseC_C)
      714 - 768
      Pfam
      PF10415 (FumaraseC_C)
8. IPR020557
   Fumarate lyase, conserved site
   1. PS00163 (FUMARATE_L...)
      623 - 632
      PROSITE patterns
      PS00163 (FUMARATE_LYASES)

no IPR
Unintegrated signatures

1. G3DSA:1.10.40.30
   711 - 769
   GENE3D
   G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
2. G3DSA:1.20.20...
   445 - 709
   GENE3D
   G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
3. PTHR11444:SF1 (ASPA...)
   300 - 769
   PANTHER
   PTHR11444:SF1 (ASPARTATE AMMONIA LYASE)
4. SSF57716 (Glucocort...)
   1 - 99
   SUPERFAMILY
   SSF57716 (Glucocorticoid receptor-like (DNA-binding domain))

### GO term prediction

#### Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0006106 fumarate metabolic process

#### Molecular Function

GO:0003676 nucleic acid binding
GO:0003824 catalytic activity
GO:0004333 fumarate hydratase activity
GO:0016829 lyase activity

#### Cellular Component

GO:0045239 tricarboxylic acid cycle enzyme complex