Protein

## EMLSAP00000011173

Length
1,336 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   181 - 214
   - Epidermal growth factor-like domain (IPR000742)
   257 - 292
   - Epidermal growth factor-like domain (IPR000742)
   293 - 330
   - Epidermal growth factor-like domain (IPR000742)
   608 - 644
   - Epidermal growth factor-like domain (IPR000742)
   926 - 965
   - Epidermal growth factor-like domain (IPR000742)
2. Domain
   245 - 331
   - Insulin-like growth factor binding protein, N-terminal (IPR009030)
   597 - 644
   - Insulin-like growth factor binding protein, N-terminal (IPR009030)
3. Domain
   293 - 330
   - EGF-like calcium-binding domain (IPR001881)
   336 - 612
   - Six-bladed beta-propeller, TolB-like (IPR011042)
   661 - 938
   - Six-bladed beta-propeller, TolB-like (IPR011042)
4. Repeat
   23 - 63
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   65 - 104
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   112 - 153
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   181 - 211
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   212 - 253
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   364 - 600
   - LDLR class B repeat (IPR000033)
   715 - 823
   - LDLR class B repeat (IPR000033)
   965 - 1,045
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   1,047 - 1,085
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)

1 200 400 600 800 1000 1200 1336

### Detailed signature matches

1. IPR000742
   Epidermal growth factor-like domain
   1. PS50026 (EGF_3)
      293 - 330
      PROSITE profiles
      PS50026 (EGF_3)
   2. SM00181 (EGF)
      181 - 214
      SMART
      SM00181 (EGF)
      296 - 330
      SMART
      SM00181 (EGF)
      608 - 644
      SMART
      SM00181 (EGF)
      926 - 965
      SMART
      SM00181 (EGF)
      257 - 292
      SMART
      SM00181 (EGF)
2. IPR009030
   Insulin-like growth factor binding protein, N-terminal
   1. SSF57184 (Growth fa...)
      597 - 644
      SUPERFAMILY
      SSF57184 (Growth factor receptor domain)
      245 - 331
      SUPERFAMILY
      SSF57184 (Growth factor receptor domain)
3. IPR001881
   EGF-like calcium-binding domain
   1. SM00179 (EGF_CA)
      293 - 330
      SMART
      SM00179 (EGF_CA)
   2. PF07645 (EGF_CA)
      293 - 327
      Pfam
      PF07645 (EGF_CA)
4. IPR011042
   Six-bladed beta-propeller, TolB-like
   1. G3DSA:2.120.1...
      336 - 612
      GENE3D
      G3DSA:2.120.10.30 (G3DSA:2.120.10.30)
      661 - 938
      GENE3D
      G3DSA:2.120.10.30 (G3DSA:2.120.10.30)
5. IPR002172
   Low-density lipoprotein (LDL) receptor class A repeat
   1. PS50068 (LDLRA_2)
      23 - 62
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,007 - 1,044
      PROSITE profiles
      PS50068 (LDLRA_2)
      212 - 252
      PROSITE profiles
      PS50068 (LDLRA_2)
      65 - 103
      PROSITE profiles
      PS50068 (LDLRA_2)
      967 - 1,003
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,047 - 1,084
      PROSITE profiles
      PS50068 (LDLRA_2)
      114 - 152
      PROSITE profiles
      PS50068 (LDLRA_2)
   2. SSF57424 (LDL recep...)
      1,006 - 1,043
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      65 - 100
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      29 - 61
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      965 - 1,003
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      218 - 250
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      114 - 150
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,047 - 1,084
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
   3. PF00057 (Ldl_recept_a)
      1,007 - 1,043
      Pfam
      PF00057 (Ldl_recept_a)
      1,048 - 1,083
      Pfam
      PF00057 (Ldl_recept_a)
      114 - 151
      Pfam
      PF00057 (Ldl_recept_a)
      966 - 1,002
      Pfam
      PF00057 (Ldl_recept_a)
      66 - 102
      Pfam
      PF00057 (Ldl_recept_a)
   4. PR00261 (LDLRECEPTOR)
      125 - 146
      PRINTS
      PR00261 (LDLRECEPTOR)
      190 - 211
      PRINTS
      PR00261 (LDLRECEPTOR)
      37 - 58
      PRINTS
      PR00261 (LDLRECEPTOR)
      77 - 98
      PRINTS
      PR00261 (LDLRECEPTOR)
      226 - 247
      PRINTS
      PR00261 (LDLRECEPTOR)
   5. G3DSA:4.10.40...
      1,011 - 1,043
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      112 - 151
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      967 - 1,010
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,047 - 1,085
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      67 - 98
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      218 - 247
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
   6. SM00192 (LDLa)
      212 - 253
      SMART
      SM00192 (LDLa)
      23 - 63
      SMART
      SM00192 (LDLa)
      1,047 - 1,085
      SMART
      SM00192 (LDLa)
      114 - 153
      SMART
      SM00192 (LDLa)
      967 - 1,004
      SMART
      SM00192 (LDLa)
      181 - 205
      SMART
      SM00192 (LDLa)
      65 - 104
      SMART
      SM00192 (LDLa)
      1,007 - 1,045
      SMART
      SM00192 (LDLa)
6. IPR000033
   LDLR class B repeat
   1. PS51120 (LDLRB)
      472 - 515
      PROSITE profiles
      PS51120 (LDLRB)
      559 - 600
      PROSITE profiles
      PS51120 (LDLRB)
      736 - 777
      PROSITE profiles
      PS51120 (LDLRB)
      384 - 428
      PROSITE profiles
      PS51120 (LDLRB)
      516 - 558
      PROSITE profiles
      PS51120 (LDLRB)
      429 - 471
      PROSITE profiles
      PS51120 (LDLRB)
      778 - 823
      PROSITE profiles
      PS51120 (LDLRB)
   2. PF00058 (Ldl_recept_b)
      472 - 512
      Pfam
      PF00058 (Ldl_recept_b)
      385 - 426
      Pfam
      PF00058 (Ldl_recept_b)
   3. SM00135 (LY)
      452 - 495
      SMART
      SM00135 (LY)
      364 - 408
      SMART
      SM00135 (LY)
      539 - 580
      SMART
      SM00135 (LY)
      758 - 801
      SMART
      SM00135 (LY)
      715 - 757
      SMART
      SM00135 (LY)
      409 - 451
      SMART
      SM00135 (LY)
      496 - 538
      SMART
      SM00135 (LY)
7. IPR023415
   Low-density lipoprotein (LDL) receptor class A, conserved site
   1. PS01209 (LDLRA_1)
      1,061 - 1,083
      PROSITE patterns
      PS01209 (LDLRA_1)
      127 - 151
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,021 - 1,043
      PROSITE patterns
      PS01209 (LDLRA_1)
      79 - 102
      PROSITE patterns
      PS01209 (LDLRA_1)
      39 - 61
      PROSITE patterns
      PS01209 (LDLRA_1)
8. IPR013032
   EGF-like, conserved site
   1. PS01186 (EGF_2)
      277 - 291
      PROSITE patterns
      PS01186 (EGF_2)
      316 - 329
      PROSITE patterns
      PS01186 (EGF_2)
9. IPR018097
   EGF-like calcium-binding, conserved site
   1. PS01187 (EGF_CA)
      293 - 316
      PROSITE patterns
      PS01187 (EGF_CA)
10. IPR000152
    EGF-type aspartate/asparagine hydroxylation site
    1. PS00010 (ASX_HYDROXYL)
       307 - 318
       PROSITE patterns
       PS00010 (ASX_HYDROXYL)

no IPR
Unintegrated signatures

1. G3DSA:2.10.25.10
   613 - 644
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   296 - 331
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   251 - 295
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
2. G3DSA:4.10.12...
   37 - 66
   GENE3D
   G3DSA:4.10.1220.10 (G3DSA:4.10.1220.10)
3. PTHR10529 (LOW-DENS...)
   33 - 1,320
   PANTHER
   PTHR10529 (LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED)
4. SSF63825 (YWTD domain)
   337 - 599
   SUPERFAMILY
   SSF63825 (YWTD domain)
   655 - 883
   SUPERFAMILY
   SSF63825 (YWTD domain)
5. SignalP-noTM
   1 - 19
   SignalP euk
   SignalP-noTM (SignalP-noTM)
6. TMhelix
   1,139 - 1,161
   TMHMM
   TMhelix (TMhelix)
   1,285 - 1,307
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0005509 calcium ion binding
GO:0005515 protein binding

#### Cellular Component

None predicted.