Protein

## EMLSAP00000003713

Length
4,559 amino acids

### Protein family membership

- E3 ubiquitin-protein ligase Highwire/Pam/Rpm-1 (IPR027047)

### Domains and repeats

1. Domain
   187 - 289
   - Armadillo-like helical (IPR011989)
   2,257 - 2,290
   - Immunoglobulin E-set (IPR014756)
   2,341 - 2,384
   - Immunoglobulin E-set (IPR014756)
   3,628 - 3,810
   - Anaphase-promoting complex, subunit 10/DOC domain (IPR004939)
2. Domain
   516 - 796
   - Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II (IPR009091)
   944 - 1,053
   - Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II (IPR009091)
   1,271 - 1,421
   - PHR (IPR012983)
   1,780 - 1,944
   - PHR (IPR012983)
   2,259 - 2,290
   - Immunoglobulin-like fold (IPR013783)
   2,341 - 2,393
   - Immunoglobulin-like fold (IPR013783)
   2,454 - 2,513
   - SH3-like domain, bacterial-type (IPR003646)
   2,571 - 2,610
   - SH3-like domain, bacterial-type (IPR003646)
   3,605 - 3,787
   - Galactose-binding domain-like (IPR008979)
   4,306 - 4,372
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
     - Zinc finger, RING-type (IPR001841)
3. Repeat
   584 - 639
   - Regulator of chromosome condensation, RCC1 (IPR000408)
   969 - 979
   - Regulator of chromosome condensation, RCC1 (IPR000408)
   982 - 1,032
   - Regulator of chromosome condensation, RCC1 (IPR000408)
   2,352 - 2,383
   - Filamin/ABP280 repeat-like (IPR017868)

1 500 1000 1500 2000 2500 3000 3500 4000 4559

### Detailed signature matches

1. IPR027047
   E3 ubiquitin-protein ligase Highwire/Pam/Rpm-1
   1. PTHR12846 (HIGHWIRE)
      115 - 4,559
      PANTHER
      PTHR12846 (HIGHWIRE)
2. IPR011989
   Armadillo-like helical
   1. G3DSA:1.25.10.10
      187 - 289
      GENE3D
      G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
3. IPR009091
   Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
   1. SSF50985 (RCC1/BLIP-II)
      952 - 1,050
      SUPERFAMILY
      SSF50985 (RCC1/BLIP-II)
      516 - 704
      SUPERFAMILY
      SSF50985 (RCC1/BLIP-II)
   2. G3DSA:2.130.1...
      944 - 1,053
      GENE3D
      G3DSA:2.130.10.30 (G3DSA:2.130.10.30)
      518 - 796
      GENE3D
      G3DSA:2.130.10.30 (G3DSA:2.130.10.30)
4. IPR012983
   PHR
   1. PF08005 (PHR)
      1,271 - 1,421
      Pfam
      PF08005 (PHR)
      1,780 - 1,944
      Pfam
      PF08005 (PHR)
5. IPR014756
   Immunoglobulin E-set
   1. SSF81296 (E set dom...)
      2,341 - 2,384
      SUPERFAMILY
      SSF81296 (E set domains)
      2,257 - 2,290
      SUPERFAMILY
      SSF81296 (E set domains)
6. IPR013783
   Immunoglobulin-like fold
   1. G3DSA:2.60.40.10
      2,341 - 2,393
      GENE3D
      G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
      2,259 - 2,290
      GENE3D
      G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
7. IPR003646
   SH3-like domain, bacterial-type
   1. PF08239 (SH3_3)
      2,571 - 2,610
      Pfam
      PF08239 (SH3_3)
      2,454 - 2,513
      Pfam
      PF08239 (SH3_3)
8. IPR008979
   Galactose-binding domain-like
   1. G3DSA:2.60.12...
      3,649 - 3,787
      GENE3D
      G3DSA:2.60.120.260 (G3DSA:2.60.120.260)
   2. SSF49785 (Galactose...)
      3,605 - 3,784
      SUPERFAMILY
      SSF49785 (Galactose-binding domain-like)
9. IPR004939
   Anaphase-promoting complex, subunit 10/DOC domain
   1. PS51284 (DOC)
      3,628 - 3,810
      PROSITE profiles
      PS51284 (DOC)
10. IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
       4,306 - 4,372
       GENE3D
       G3DSA:3.30.40.10 (G3DSA:3.30.40.10)
11. IPR001841
    Zinc finger, RING-type
    1. PF13639 (zf-RING_2)
       4,309 - 4,361
       Pfam
       PF13639 (zf-RING_2)
    2. PS50089 (ZF_RING_2)
       4,310 - 4,361
       PROSITE profiles
       PS50089 (ZF_RING_2)
    3. SM00184 (RING)
       4,310 - 4,360
       SMART
       SM00184 (RING)
12. IPR000408
    Regulator of chromosome condensation, RCC1
    1. PS00626 (RCC1_2)
       969 - 979
       PROSITE patterns
       PS00626 (RCC1_2)
    2. PF00415 (RCC1)
       982 - 1,029
       Pfam
       PF00415 (RCC1)
    3. PS50012 (RCC1_3)
       584 - 639
       PROSITE profiles
       PS50012 (RCC1_3)
       983 - 1,032
       PROSITE profiles
       PS50012 (RCC1_3)
13. IPR017868
    Filamin/ABP280 repeat-like
    1. PS50194 (FILAMIN_RE...)
       2,352 - 2,383
       PROSITE profiles
       PS50194 (FILAMIN_REPEAT)

no IPR
Unintegrated signatures

1. PTHR12846:SF1 (HIGH...)
   115 - 4,559
   PANTHER
   PTHR12846:SF1 (HIGHWIRE)
2. SSF57850 (RING/U-box)
   4,307 - 4,371
   SUPERFAMILY
   SSF57850 (RING/U-box)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0004842 ubiquitin-protein ligase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding

#### Cellular Component

None predicted.