Protein

## EMLSAP00000007936

Length
2,138 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   93 - 739
   - VPS10 (IPR006581)
   741 - 994
   - Six-bladed beta-propeller, TolB-like (IPR011042)
   995 - 1,042
   - Epidermal growth factor-like domain (IPR000742)
   1,140 - 1,176
   - Epidermal growth factor-like domain (IPR000742)
   1,422 - 1,459
   - Epidermal growth factor-like domain (IPR000742)
   1,462 - 1,749
   - Immunoglobulin-like fold (IPR013783)
     - Fibronectin, type III (IPR003961)
   1,950 - 2,045
   - Fibronectin, type III (IPR003961)
2. Domain
   1,753 - 1,950
   - Immunoglobulin-like fold (IPR013783)
     - Fibronectin, type III (IPR003961)
3. Repeat
   763 - 985
   - LDLR class B repeat (IPR000033)
   1,059 - 1,138
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   1,140 - 1,177
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   1,180 - 1,258
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   1,270 - 1,310
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   1,331 - 1,369
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   1,371 - 1,410
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
   1,422 - 1,464
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2138

### Detailed signature matches

1. IPR006581
   VPS10
   1. SM00602 (VPS10)
      93 - 739
      SMART
      SM00602 (VPS10)
2. IPR011042
   Six-bladed beta-propeller, TolB-like
   1. G3DSA:2.120.1...
      741 - 994
      GENE3D
      G3DSA:2.120.10.30 (G3DSA:2.120.10.30)
3. IPR000742
   Epidermal growth factor-like domain
   1. SM00181 (EGF)
      995 - 1,042
      SMART
      SM00181 (EGF)
      1,422 - 1,459
      SMART
      SM00181 (EGF)
      1,140 - 1,176
      SMART
      SM00181 (EGF)
4. IPR013783
   Immunoglobulin-like fold
   1. G3DSA:2.60.40.10
      1,565 - 1,651
      GENE3D
      G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
      1,854 - 1,934
      GENE3D
      G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
      1,766 - 1,849
      GENE3D
      G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
      1,652 - 1,749
      GENE3D
      G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
5. IPR003961
   Fibronectin, type III
   1. SSF49265 (Fibronect...)
      1,767 - 1,933
      SUPERFAMILY
      SSF49265 (Fibronectin type III)
      1,476 - 1,656
      SUPERFAMILY
      SSF49265 (Fibronectin type III)
      1,665 - 1,749
      SUPERFAMILY
      SSF49265 (Fibronectin type III)
      1,954 - 2,035
      SUPERFAMILY
      SSF49265 (Fibronectin type III)
   2. SM00060 (FN3)
      1,465 - 1,549
      SMART
      SM00060 (FN3)
      1,950 - 2,036
      SMART
      SM00060 (FN3)
      1,853 - 1,943
      SMART
      SM00060 (FN3)
      1,755 - 1,838
      SMART
      SM00060 (FN3)
      1,661 - 1,740
      SMART
      SM00060 (FN3)
      1,565 - 1,645
      SMART
      SM00060 (FN3)
   3. PF00041 (fn3)
      1,664 - 1,743
      Pfam
      PF00041 (fn3)
      1,567 - 1,645
      Pfam
      PF00041 (fn3)
   4. PS50853 (FN3)
      1,662 - 1,749
      PROSITE profiles
      PS50853 (FN3)
      1,565 - 1,654
      PROSITE profiles
      PS50853 (FN3)
      1,753 - 1,848
      PROSITE profiles
      PS50853 (FN3)
      1,852 - 1,950
      PROSITE profiles
      PS50853 (FN3)
      1,953 - 2,045
      PROSITE profiles
      PS50853 (FN3)
      1,462 - 1,557
      PROSITE profiles
      PS50853 (FN3)
6. IPR000033
   LDLR class B repeat
   1. PS51120 (LDLRB)
      873 - 918
      PROSITE profiles
      PS51120 (LDLRB)
      828 - 872
      PROSITE profiles
      PS51120 (LDLRB)
      783 - 827
      PROSITE profiles
      PS51120 (LDLRB)
      919 - 964
      PROSITE profiles
      PS51120 (LDLRB)
   2. PF00058 (Ldl_recept_b)
      919 - 961
      Pfam
      PF00058 (Ldl_recept_b)
      828 - 870
      Pfam
      PF00058 (Ldl_recept_b)
      873 - 916
      Pfam
      PF00058 (Ldl_recept_b)
   3. SM00135 (LY)
      898 - 941
      SMART
      SM00135 (LY)
      763 - 805
      SMART
      SM00135 (LY)
      852 - 897
      SMART
      SM00135 (LY)
      808 - 850
      SMART
      SM00135 (LY)
      945 - 985
      SMART
      SM00135 (LY)
7. IPR002172
   Low-density lipoprotein (LDL) receptor class A repeat
   1. PS50068 (LDLRA_2)
      1,220 - 1,256
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,140 - 1,176
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,062 - 1,098
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,180 - 1,217
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,273 - 1,309
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,422 - 1,459
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,334 - 1,368
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,372 - 1,409
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,101 - 1,137
      PROSITE profiles
      PS50068 (LDLRA_2)
   2. SSF57424 (LDL recep...)
      1,332 - 1,367
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,270 - 1,308
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,371 - 1,408
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,096 - 1,136
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,422 - 1,464
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,140 - 1,176
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,220 - 1,258
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,059 - 1,097
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,180 - 1,216
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
   3. PF00057 (Ldl_recept_a)
      1,140 - 1,175
      Pfam
      PF00057 (Ldl_recept_a)
      1,101 - 1,136
      Pfam
      PF00057 (Ldl_recept_a)
      1,180 - 1,216
      Pfam
      PF00057 (Ldl_recept_a)
      1,334 - 1,363
      Pfam
      PF00057 (Ldl_recept_a)
      1,061 - 1,097
      Pfam
      PF00057 (Ldl_recept_a)
      1,273 - 1,308
      Pfam
      PF00057 (Ldl_recept_a)
      1,219 - 1,255
      Pfam
      PF00057 (Ldl_recept_a)
      1,372 - 1,408
      Pfam
      PF00057 (Ldl_recept_a)
      1,423 - 1,458
      Pfam
      PF00057 (Ldl_recept_a)
   4. PR00261 (LDLRECEPTOR)
      1,073 - 1,094
      PRINTS
      PR00261 (LDLRECEPTOR)
      1,284 - 1,305
      PRINTS
      PR00261 (LDLRECEPTOR)
      1,231 - 1,252
      PRINTS
      PR00261 (LDLRECEPTOR)
      1,112 - 1,133
      PRINTS
      PR00261 (LDLRECEPTOR)
      1,151 - 1,172
      PRINTS
      PR00261 (LDLRECEPTOR)
      1,192 - 1,213
      PRINTS
      PR00261 (LDLRECEPTOR)
   5. G3DSA:4.10.40...
      1,422 - 1,461
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,180 - 1,224
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,334 - 1,367
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,373 - 1,408
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,225 - 1,255
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,271 - 1,308
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,140 - 1,176
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,061 - 1,097
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,100 - 1,136
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
   6. SM00192 (LDLa)
      1,180 - 1,218
      SMART
      SM00192 (LDLa)
      1,331 - 1,369
      SMART
      SM00192 (LDLa)
      1,372 - 1,410
      SMART
      SM00192 (LDLa)
      1,140 - 1,177
      SMART
      SM00192 (LDLa)
      1,062 - 1,099
      SMART
      SM00192 (LDLa)
      1,101 - 1,138
      SMART
      SM00192 (LDLa)
      1,273 - 1,310
      SMART
      SM00192 (LDLa)
      1,220 - 1,257
      SMART
      SM00192 (LDLa)
      1,422 - 1,460
      SMART
      SM00192 (LDLa)
8. IPR023415
   Low-density lipoprotein (LDL) receptor class A, conserved site
   1. PS01209 (LDLRA_1)
      1,386 - 1,408
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,153 - 1,175
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,075 - 1,097
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,233 - 1,255
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,114 - 1,136
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,286 - 1,308
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,436 - 1,458
      PROSITE patterns
      PS01209 (LDLRA_1)

no IPR
Unintegrated signatures

1. G3DSA:2.130.1...
   383 - 584
   GENE3D
   G3DSA:2.130.10.140 (G3DSA:2.130.10.140)
   81 - 221
   GENE3D
   G3DSA:2.130.10.140 (G3DSA:2.130.10.140)
2. PTHR12106 (SORTILIN...)
   62 - 1,225
   PANTHER
   PTHR12106 (SORTILIN RELATED)
3. PTHR12106:SF7 (SORT...)
   62 - 1,225
   PANTHER
   PTHR12106:SF7 (SORTILIN-RELATED RECEPTOR)
4. SSF110296 (Oligoxyl...)
   66 - 230
   SUPERFAMILY
   SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)
   412 - 597
   SUPERFAMILY
   SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)
5. SSF63825 (YWTD domain)
   751 - 993
   SUPERFAMILY
   SSF63825 (YWTD domain)
6. SignalP-TM
   1 - 22
   SignalP Gram+ prok
   SignalP-TM (SignalP-TM)
7. SignalP-noTM
   1 - 20
   SignalP euk
   SignalP-noTM (SignalP-noTM)
8. TMhelix
   2,060 - 2,082
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0005515 protein binding

#### Cellular Component

GO:0016021 integral component of membrane