Protein

## EMLSAP00000009110

Length
878 amino acids

### Protein family membership

- Histone H4-K20 methyltransferase (IPR016858)

- Tubulin (IPR000217)
  - Alpha tubulin (IPR002452)

### Domains and repeats

1. Domain
   288 - 416
   - SET domain (IPR001214)
   665 - 810
   - Tubulin/FtsZ, 2-layer sandwich domain (IPR018316)
2. Domain
   422 - 685
   - Tubulin/FtsZ, GTPase domain (IPR003008)
   802 - 856
   - Tubulin, C-terminal (IPR023123)
3. Domain
   663 - 852
   - Tubulin/FtsZ, C-terminal (IPR008280)

1 100 200 300 400 500 600 700 800 878

### Detailed signature matches

1. IPR016858
   Histone H4-K20 methyltransferase
   1. PS51571 (SAM_MT43_P...)
      81 - 426
      PROSITE profiles
      PS51571 (SAM_MT43_PR_SET)
2. IPR000217
   Tubulin
   1. PR01161 (TUBULIN)
      470 - 489
      PRINTS
      PR01161 (TUBULIN)
      525 - 549
      PRINTS
      PR01161 (TUBULIN)
      512 - 523
      PRINTS
      PR01161 (TUBULIN)
      426 - 446
      PRINTS
      PR01161 (TUBULIN)
      551 - 569
      PRINTS
      PR01161 (TUBULIN)
      570 - 591
      PRINTS
      PR01161 (TUBULIN)
      595 - 608
      PRINTS
      PR01161 (TUBULIN)
      609 - 629
      PRINTS
      PR01161 (TUBULIN)
      797 - 825
      PRINTS
      PR01161 (TUBULIN)
   2. PTHR11588 (TUBULIN)
      423 - 875
      PANTHER
      PTHR11588 (TUBULIN)
3. IPR002452
   Alpha tubulin
   1. PR01162 (ALPHATUBULIN)
      434 - 449
      PRINTS
      PR01162 (ALPHATUBULIN)
      764 - 777
      PRINTS
      PR01162 (ALPHATUBULIN)
      631 - 643
      PRINTS
      PR01162 (ALPHATUBULIN)
      537 - 545
      PRINTS
      PR01162 (ALPHATUBULIN)
      505 - 518
      PRINTS
      PR01162 (ALPHATUBULIN)
      777 - 796
      PRINTS
      PR01162 (ALPHATUBULIN)
      578 - 589
      PRINTS
      PR01162 (ALPHATUBULIN)
      738 - 759
      PRINTS
      PR01162 (ALPHATUBULIN)
      839 - 855
      PRINTS
      PR01162 (ALPHATUBULIN)
      802 - 818
      PRINTS
      PR01162 (ALPHATUBULIN)
      565 - 577
      PRINTS
      PR01162 (ALPHATUBULIN)
4. IPR001214
   SET domain
   1. PF00856 (SET)
      299 - 410
      Pfam
      PF00856 (SET)
   2. PS50280 (SET)
      288 - 410
      PROSITE profiles
      PS50280 (SET)
   3. SM00317 (SET)
      288 - 416
      SMART
      SM00317 (SET)
5. IPR003008
   Tubulin/FtsZ, GTPase domain
   1. SSF52490 (Tubulin n...)
      422 - 661
      SUPERFAMILY
      SSF52490 (Tubulin nucleotide-binding domain-like)
   2. PF00091 (Tubulin)
      423 - 641
      Pfam
      PF00091 (Tubulin)
   3. G3DSA:3.40.50...
      423 - 685
      GENE3D
      G3DSA:3.40.50.1440 (G3DSA:3.40.50.1440)
   4. SM00864 (Tubulin)
      466 - 663
      SMART
      SM00864 (Tubulin)
6. IPR008280
   Tubulin/FtsZ, C-terminal
   1. SSF55307 (Tubulin C...)
      663 - 852
      SUPERFAMILY
      SSF55307 (Tubulin C-terminal domain-like)
7. IPR018316
   Tubulin/FtsZ, 2-layer sandwich domain
   1. G3DSA:3.30.13...
      686 - 800
      GENE3D
      G3DSA:3.30.1330.20 (G3DSA:3.30.1330.20)
   2. PF03953 (Tubulin_C)
      680 - 809
      Pfam
      PF03953 (Tubulin_C)
   3. SM00865 (Tubulin_C)
      665 - 810
      SMART
      SM00865 (Tubulin_C)
8. IPR023123
   Tubulin, C-terminal
   1. G3DSA:1.10.28...
      802 - 856
      GENE3D
      G3DSA:1.10.287.600 (G3DSA:1.10.287.600)
9. IPR017975
   Tubulin, conserved site
   1. PS00227 (TUBULIN)
      559 - 565
      PROSITE patterns
      PS00227 (TUBULIN)

no IPR
Unintegrated signatures

1. G3DSA:2.170.2...
   194 - 415
   GENE3D
   G3DSA:2.170.270.10 (G3DSA:2.170.270.10)
2. PTHR11588:SF41 (SUB...)
   423 - 875
   PANTHER
   PTHR11588:SF41 (SUBFAMILY NOT NAMED)
3. SSF82199 (SET domain)
   289 - 420
   SUPERFAMILY
   SSF82199 (SET domain)

### GO term prediction

#### Biological Process

GO:0006184 GTP catabolic process
GO:0007017 microtubule-based process
GO:0051258 protein polymerization

#### Molecular Function

GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0018024 histone-lysine N-methyltransferase activity

#### Cellular Component

GO:0005874 microtubule
GO:0043234 protein complex