Protein

## EMLSAP00000010768

Length
1,915 amino acids

### Protein family membership

- Voltage gated sodium channel, alpha subunit (IPR001696)
  - Sodium channel protein para (IPR028814)

### Domains and repeats

1. Domain
   155 - 364
   - Ion transport domain (IPR005821)
   792 - 945
   - Ion transport domain (IPR005821)
   1,106 - 1,195
   - Sodium ion transport-associated (IPR010526)
   1,221 - 1,445
   - Ion transport domain (IPR005821)
   1,516 - 1,705
   - Ion transport domain (IPR005821)
2. Domain
   462 - 638
   - Domain of unknown function DUF3451 (IPR024583)
   750 - 859
   - Voltage-dependent channel, four helix bundle domain (IPR027359)
   1,181 - 1,292
   - Voltage-dependent channel, four helix bundle domain (IPR027359)
   1,510 - 1,591
   - Voltage-dependent channel, four helix bundle domain (IPR027359)
   1,723 - 1,758
   - EF-hand domain (IPR002048)

1 200 400 600 800 1000 1200 1400 1600 1800 1915

### Detailed signature matches

1. IPR001696
   Voltage gated sodium channel, alpha subunit
   1. PR00170 (NACHANNEL)
      1,723 - 1,736
      PRINTS
      PR00170 (NACHANNEL)
      1,688 - 1,707
      PRINTS
      PR00170 (NACHANNEL)
2. IPR028814
   Sodium channel protein para
   1. PTHR10037:SF15 (SOD...)
      72 - 1,885
      PANTHER
      PTHR10037:SF15 (SODIUM CHANNEL PROTEIN PARA)
3. IPR005821
   Ion transport domain
   1. PF00520 (Ion_trans)
      1,516 - 1,705
      Pfam
      PF00520 (Ion_trans)
      1,221 - 1,445
      Pfam
      PF00520 (Ion_trans)
      155 - 364
      Pfam
      PF00520 (Ion_trans)
      792 - 945
      Pfam
      PF00520 (Ion_trans)
4. IPR024583
   Domain of unknown function DUF3451
   1. PF11933 (DUF3451)
      462 - 638
      Pfam
      PF11933 (DUF3451)
5. IPR027359
   Voltage-dependent channel, four helix bundle domain
   1. G3DSA:1.20.12...
      750 - 859
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      1,510 - 1,591
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      1,181 - 1,292
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
6. IPR010526
   Sodium ion transport-associated
   1. PF06512 (Na_trans_a...)
      1,106 - 1,195
      Pfam
      PF06512 (Na_trans_assoc)
7. IPR002048
   EF-hand domain
   1. PS50222 (EF_HAND_2)
      1,723 - 1,758
      PROSITE profiles
      PS50222 (EF_HAND_2)

no IPR
Unintegrated signatures

1. Coil
   372 - 406
   COILS
   Coil (Coil)
   407 - 411
   COILS
   Coil (Coil)
2. G3DSA:1.20.5.150
   1,447 - 1,477
   GENE3D
   G3DSA:1.20.5.150 (G3DSA:1.20.5.150)
3. PTHR10037 (VOLTAGE-...)
   72 - 1,885
   PANTHER
   PTHR10037 (VOLTAGE-GATED CATION CHANNEL (CALCIUM AND SODIUM))
4. SSF81324 (Voltage-g...)
   1,497 - 1,635
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,685 - 1,712
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,374 - 1,452
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,185 - 1,339
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   747 - 936
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   149 - 229
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   303 - 368
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
5. TMhelix
   924 - 946
   TMHMM
   TMhelix (TMhelix)
   177 - 199
   TMHMM
   TMhelix (TMhelix)
   1,606 - 1,628
   TMHMM
   TMhelix (TMhelix)
   1,543 - 1,565
   TMHMM
   TMhelix (TMhelix)
   1,225 - 1,247
   TMHMM
   TMhelix (TMhelix)
   1,257 - 1,279
   TMHMM
   TMhelix (TMhelix)
   740 - 762
   TMHMM
   TMhelix (TMhelix)
   783 - 805
   TMHMM
   TMhelix (TMhelix)
   875 - 897
   TMHMM
   TMhelix (TMhelix)
   1,381 - 1,400
   TMHMM
   TMhelix (TMhelix)
   1,508 - 1,530
   TMHMM
   TMhelix (TMhelix)
   1,683 - 1,705
   TMHMM
   TMhelix (TMhelix)
   825 - 847
   TMHMM
   TMhelix (TMhelix)
   209 - 231
   TMHMM
   TMhelix (TMhelix)
   1,302 - 1,333
   TMHMM
   TMhelix (TMhelix)
   1,424 - 1,446
   TMHMM
   TMhelix (TMhelix)
   342 - 364
   TMHMM
   TMhelix (TMhelix)
   142 - 164
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport

#### Molecular Function

GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005509 calcium ion binding

#### Cellular Component

GO:0001518 voltage-gated sodium channel complex
GO:0016020 membrane