Protein

## EMLSAP00000012565

Length
631 amino acids

### Protein family membership

- Phosphoinositide phospholipase C family (IPR001192)

### Domains and repeats

1. Domain
   57 - 209
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
   235 - 285
   - EF-hand domain pair (IPR011992)
   286 - 357
   - EF-hand domain pair (IPR011992)
     - Phospholipase C, phosphoinositol-specific, EF-hand-like (IPR015359)
   369 - 496
   - Phospholipase C, phosphatidylinositol-specific , X domain (IPR000909)
   533 - 631
   - Phospholipase C, phosphatidylinositol-specific, Y domain (IPR001711)
2. Domain
   215 - 250
   - EF-hand domain (IPR002048)
   287 - 321
   - EF-hand domain (IPR002048)
   367 - 628
   - PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (IPR017946)

1 100 200 300 400 500 631

### Detailed signature matches

1. IPR001192
   Phosphoinositide phospholipase C family
   1. PR00390 (PHPHLIPASEC)
      611 - 629
      PRINTS
      PR00390 (PHPHLIPASEC)
      374 - 392
      PRINTS
      PR00390 (PHPHLIPASEC)
      590 - 611
      PRINTS
      PR00390 (PHPHLIPASEC)
   2. PTHR10336 (PHOSPHOI...)
      51 - 627
      PANTHER
      PTHR10336 (PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN)
2. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      57 - 209
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
3. IPR001849
   Pleckstrin homology domain
   1. SM00233 (PH)
      63 - 207
      SMART
      SM00233 (PH)
4. IPR002048
   EF-hand domain
   1. PS50222 (EF_HAND_2)
      287 - 321
      PROSITE profiles
      PS50222 (EF_HAND_2)
      215 - 250
      PROSITE profiles
      PS50222 (EF_HAND_2)
5. IPR011992
   EF-hand domain pair
   1. G3DSA:1.10.23...
      235 - 285
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
      286 - 357
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
6. IPR015359
   Phospholipase C, phosphoinositol-specific, EF-hand-like
   1. PF09279 (EF-hand_like)
      291 - 354
      Pfam
      PF09279 (EF-hand_like)
7. IPR017946
   PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
   1. G3DSA:3.20.20...
      367 - 628
      GENE3D
      G3DSA:3.20.20.190 (G3DSA:3.20.20.190)
   2. SSF51695 (PLC-like ...)
      369 - 628
      SUPERFAMILY
      SSF51695 (PLC-like phosphodiesterases)
8. IPR000909
   Phospholipase C, phosphatidylinositol-specific , X domain
   1. PF00388 (PI-PLC-X)
      396 - 496
      Pfam
      PF00388 (PI-PLC-X)
   2. PS50007 (PIPLC_X_DO...)
      369 - 496
      PROSITE profiles
      PS50007 (PIPLC_X_DOMAIN)
   3. SM00148 (PLCXc)
      369 - 496
      SMART
      SM00148 (PLCXc)
9. IPR001711
   Phospholipase C, phosphatidylinositol-specific, Y domain
   1. PS50008 (PIPLC_Y_DO...)
      534 - 627
      PROSITE profiles
      PS50008 (PIPLC_Y_DOMAIN)
   2. PF00387 (PI-PLC-Y)
      533 - 628
      Pfam
      PF00387 (PI-PLC-Y)
   3. SM00149 (PLCYc)
      534 - 631
      SMART
      SM00149 (PLCYc)
10. IPR018247
    EF-Hand 1, calcium-binding site
    1. PS00018 (EF_HAND_1)
       228 - 240
       PROSITE patterns
       PS00018 (EF_HAND_1)

no IPR
Unintegrated signatures

1. SSF47473 (EF-hand)
   216 - 356
   SUPERFAMILY
   SSF47473 (EF-hand)
2. SSF50729 (PH domain...)
   58 - 204
   SUPERFAMILY
   SSF50729 (PH domain-like)

### GO term prediction

#### Biological Process

GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

#### Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0008081 phosphoric diester hydrolase activity

#### Cellular Component

None predicted.