Protein

## EMLSAP00000003435

Length
1,120 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   26 - 62
   - Epidermal growth factor-like domain (IPR000742)
   64 - 100
   - Epidermal growth factor-like domain (IPR000742)
   102 - 137
   - Epidermal growth factor-like domain (IPR000742)
   139 - 175
   - Epidermal growth factor-like domain (IPR000742)
   177 - 212
   - Epidermal growth factor-like domain (IPR000742)
   214 - 250
   - Epidermal growth factor-like domain (IPR000742)
   252 - 288
   - Epidermal growth factor-like domain (IPR000742)
   290 - 326
   - Epidermal growth factor-like domain (IPR000742)
   328 - 364
   - Epidermal growth factor-like domain (IPR000742)
   366 - 405
   - Epidermal growth factor-like domain (IPR000742)
   407 - 443
   - Epidermal growth factor-like domain (IPR000742)
   445 - 481
   - Epidermal growth factor-like domain (IPR000742)
   483 - 519
   - Epidermal growth factor-like domain (IPR000742)
   521 - 557
   - Epidermal growth factor-like domain (IPR000742)
   559 - 596
   - Epidermal growth factor-like domain (IPR000742)
   598 - 635
   - Epidermal growth factor-like domain (IPR000742)
   640 - 683
   - Epidermal growth factor-like domain (IPR000742)
   685 - 721
   - Epidermal growth factor-like domain (IPR000742)
   723 - 759
   - Epidermal growth factor-like domain (IPR000742)
   761 - 797
   - Epidermal growth factor-like domain (IPR000742)
   799 - 837
   - Epidermal growth factor-like domain (IPR000742)
   839 - 877
   - Epidermal growth factor-like domain (IPR000742)
   879 - 916
   - Epidermal growth factor-like domain (IPR000742)
   919 - 954
   - Epidermal growth factor-like domain (IPR000742)
   1,015 - 1,103
   - Notch domain (IPR000800)
2. Domain
   26 - 62
   - EGF-like calcium-binding domain (IPR001881)
   64 - 100
   - EGF-like calcium-binding domain (IPR001881)
   102 - 137
   - EGF-like calcium-binding domain (IPR001881)
   139 - 175
   - EGF-like calcium-binding domain (IPR001881)
   177 - 212
   - EGF-like calcium-binding domain (IPR001881)
   214 - 250
   - EGF-like calcium-binding domain (IPR001881)
   252 - 288
   - EGF-like calcium-binding domain (IPR001881)
   290 - 326
   - EGF-like calcium-binding domain (IPR001881)
   328 - 364
   - EGF-like calcium-binding domain (IPR001881)
   366 - 405
   - EGF-like calcium-binding domain (IPR001881)
   407 - 443
   - EGF-like calcium-binding domain (IPR001881)
   445 - 481
   - EGF-like calcium-binding domain (IPR001881)
   483 - 519
   - EGF-like calcium-binding domain (IPR001881)
   522 - 557
   - EGF-like calcium-binding domain (IPR001881)
   559 - 596
   - EGF-like calcium-binding domain (IPR001881)
   599 - 635
   - EGF-like calcium-binding domain (IPR001881)
   649 - 683
   - EGF-like calcium-binding domain (IPR001881)
   685 - 721
   - EGF-like calcium-binding domain (IPR001881)
   723 - 759
   - EGF-like calcium-binding domain (IPR001881)
   761 - 797
   - EGF-like calcium-binding domain (IPR001881)
   799 - 837
   - EGF-like calcium-binding domain (IPR001881)
   839 - 877
   - EGF-like calcium-binding domain (IPR001881)
   883 - 916
   - EGF-like calcium-binding domain (IPR001881)
   919 - 954
   - EGF-like calcium-binding domain (IPR001881)
   975 - 1,017
   - Notch domain (IPR000800)
3. Domain
   90 - 219
   - Insulin-like growth factor binding protein, N-terminal (IPR009030)
4. Domain
   217 - 332
   - Insulin-like growth factor binding protein, N-terminal (IPR009030)
   395 - 525
   - Insulin-like growth factor binding protein, N-terminal (IPR009030)

1 200 400 600 800 1000 1120

### Detailed signature matches

1. IPR000742
   Epidermal growth factor-like domain
   1. PF00008 (EGF)
      256 - 286
      Pfam
      PF00008 (EGF)
      181 - 208
      Pfam
      PF00008 (EGF)
      655 - 680
      Pfam
      PF00008 (EGF)
      72 - 97
      Pfam
      PF00008 (EGF)
      689 - 719
      Pfam
      PF00008 (EGF)
      487 - 515
      Pfam
      PF00008 (EGF)
      218 - 248
      Pfam
      PF00008 (EGF)
      525 - 555
      Pfam
      PF00008 (EGF)
      328 - 362
      Pfam
      PF00008 (EGF)
      727 - 755
      Pfam
      PF00008 (EGF)
      30 - 58
      Pfam
      PF00008 (EGF)
      294 - 323
      Pfam
      PF00008 (EGF)
      883 - 913
      Pfam
      PF00008 (EGF)
      563 - 594
      Pfam
      PF00008 (EGF)
   2. PS50026 (EGF_3)
      290 - 326
      PROSITE profiles
      PS50026 (EGF_3)
      685 - 721
      PROSITE profiles
      PS50026 (EGF_3)
      598 - 635
      PROSITE profiles
      PS50026 (EGF_3)
      521 - 557
      PROSITE profiles
      PS50026 (EGF_3)
      919 - 954
      PROSITE profiles
      PS50026 (EGF_3)
      723 - 759
      PROSITE profiles
      PS50026 (EGF_3)
      646 - 683
      PROSITE profiles
      PS50026 (EGF_3)
      26 - 62
      PROSITE profiles
      PS50026 (EGF_3)
      799 - 837
      PROSITE profiles
      PS50026 (EGF_3)
      879 - 916
      PROSITE profiles
      PS50026 (EGF_3)
      64 - 100
      PROSITE profiles
      PS50026 (EGF_3)
      252 - 288
      PROSITE profiles
      PS50026 (EGF_3)
      559 - 596
      PROSITE profiles
      PS50026 (EGF_3)
      839 - 877
      PROSITE profiles
      PS50026 (EGF_3)
      407 - 443
      PROSITE profiles
      PS50026 (EGF_3)
      366 - 405
      PROSITE profiles
      PS50026 (EGF_3)
      139 - 175
      PROSITE profiles
      PS50026 (EGF_3)
      483 - 519
      PROSITE profiles
      PS50026 (EGF_3)
      445 - 481
      PROSITE profiles
      PS50026 (EGF_3)
      102 - 137
      PROSITE profiles
      PS50026 (EGF_3)
      177 - 212
      PROSITE profiles
      PS50026 (EGF_3)
      328 - 364
      PROSITE profiles
      PS50026 (EGF_3)
      761 - 797
      PROSITE profiles
      PS50026 (EGF_3)
      214 - 250
      PROSITE profiles
      PS50026 (EGF_3)
   3. SM00181 (EGF)
      448 - 481
      SMART
      SM00181 (EGF)
      331 - 364
      SMART
      SM00181 (EGF)
      882 - 916
      SMART
      SM00181 (EGF)
      688 - 721
      SMART
      SM00181 (EGF)
      640 - 683
      SMART
      SM00181 (EGF)
      524 - 557
      SMART
      SM00181 (EGF)
      105 - 137
      SMART
      SM00181 (EGF)
      410 - 443
      SMART
      SM00181 (EGF)
      67 - 100
      SMART
      SM00181 (EGF)
      293 - 326
      SMART
      SM00181 (EGF)
      486 - 519
      SMART
      SM00181 (EGF)
      601 - 635
      SMART
      SM00181 (EGF)
      217 - 250
      SMART
      SM00181 (EGF)
      922 - 954
      SMART
      SM00181 (EGF)
      369 - 405
      SMART
      SM00181 (EGF)
      29 - 62
      SMART
      SM00181 (EGF)
      764 - 797
      SMART
      SM00181 (EGF)
      180 - 212
      SMART
      SM00181 (EGF)
      562 - 596
      SMART
      SM00181 (EGF)
      802 - 837
      SMART
      SM00181 (EGF)
      842 - 877
      SMART
      SM00181 (EGF)
      142 - 175
      SMART
      SM00181 (EGF)
      726 - 759
      SMART
      SM00181 (EGF)
      255 - 288
      SMART
      SM00181 (EGF)
2. IPR001881
   EGF-like calcium-binding domain
   1. SM00179 (EGF_CA)
      64 - 100
      SMART
      SM00179 (EGF_CA)
      649 - 683
      SMART
      SM00179 (EGF_CA)
      761 - 797
      SMART
      SM00179 (EGF_CA)
      407 - 443
      SMART
      SM00179 (EGF_CA)
      559 - 596
      SMART
      SM00179 (EGF_CA)
      290 - 326
      SMART
      SM00179 (EGF_CA)
      102 - 137
      SMART
      SM00179 (EGF_CA)
      366 - 405
      SMART
      SM00179 (EGF_CA)
      599 - 635
      SMART
      SM00179 (EGF_CA)
      839 - 877
      SMART
      SM00179 (EGF_CA)
      483 - 519
      SMART
      SM00179 (EGF_CA)
      214 - 250
      SMART
      SM00179 (EGF_CA)
      723 - 759
      SMART
      SM00179 (EGF_CA)
      139 - 175
      SMART
      SM00179 (EGF_CA)
      177 - 212
      SMART
      SM00179 (EGF_CA)
      252 - 288
      SMART
      SM00179 (EGF_CA)
      522 - 557
      SMART
      SM00179 (EGF_CA)
      883 - 916
      SMART
      SM00179 (EGF_CA)
      919 - 954
      SMART
      SM00179 (EGF_CA)
      445 - 481
      SMART
      SM00179 (EGF_CA)
      685 - 721
      SMART
      SM00179 (EGF_CA)
      328 - 364
      SMART
      SM00179 (EGF_CA)
      26 - 62
      SMART
      SM00179 (EGF_CA)
      799 - 837
      SMART
      SM00179 (EGF_CA)
   2. PF07645 (EGF_CA)
      762 - 792
      Pfam
      PF07645 (EGF_CA)
      407 - 438
      Pfam
      PF07645 (EGF_CA)
3. IPR009030
   Insulin-like growth factor binding protein, N-terminal
   1. SSF57184 (Growth fa...)
      90 - 219
      SUPERFAMILY
      SSF57184 (Growth factor receptor domain)
      217 - 332
      SUPERFAMILY
      SSF57184 (Growth factor receptor domain)
      395 - 525
      SUPERFAMILY
      SSF57184 (Growth factor receptor domain)
4. IPR000800
   Notch domain
   1. SM00004 (NL)
      975 - 1,013
      SMART
      SM00004 (NL)
      1,060 - 1,099
      SMART
      SM00004 (NL)
      1,015 - 1,059
      SMART
      SM00004 (NL)
   2. PR01452 (LNOTCHREPEAT)
      1,000 - 1,013
      PRINTS
      PR01452 (LNOTCHREPEAT)
      1,086 - 1,098
      PRINTS
      PR01452 (LNOTCHREPEAT)
   3. PF00066 (Notch)
      1,063 - 1,099
      Pfam
      PF00066 (Notch)
      1,019 - 1,059
      Pfam
      PF00066 (Notch)
      980 - 1,013
      Pfam
      PF00066 (Notch)
   4. PS50258 (LNR)
      1,022 - 1,063
      PROSITE profiles
      PS50258 (LNR)
      982 - 1,017
      PROSITE profiles
      PS50258 (LNR)
      1,065 - 1,103
      PROSITE profiles
      PS50258 (LNR)
   5. SSF90193 (Notch domain)
      1,030 - 1,058
      SUPERFAMILY
      SSF90193 (Notch domain)
      982 - 1,012
      SUPERFAMILY
      SSF90193 (Notch domain)
      1,066 - 1,099
      SUPERFAMILY
      SSF90193 (Notch domain)
5. IPR018097
   EGF-like calcium-binding, conserved site
   1. PS01187 (EGF_CA)
      761 - 785
      PROSITE patterns
      PS01187 (EGF_CA)
      252 - 276
      PROSITE patterns
      PS01187 (EGF_CA)
      521 - 545
      PROSITE patterns
      PS01187 (EGF_CA)
      445 - 469
      PROSITE patterns
      PS01187 (EGF_CA)
      723 - 747
      PROSITE patterns
      PS01187 (EGF_CA)
      26 - 50
      PROSITE patterns
      PS01187 (EGF_CA)
      328 - 352
      PROSITE patterns
      PS01187 (EGF_CA)
      102 - 125
      PROSITE patterns
      PS01187 (EGF_CA)
      407 - 431
      PROSITE patterns
      PS01187 (EGF_CA)
      177 - 200
      PROSITE patterns
      PS01187 (EGF_CA)
6. IPR000152
   EGF-type aspartate/asparagine hydroxylation site
   1. PS00010 (ASX_HYDROXYL)
      422 - 433
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      191 - 202
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      79 - 90
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      460 - 471
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      738 - 749
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      343 - 354
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      776 - 787
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      41 - 52
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      933 - 944
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      536 - 547
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      267 - 278
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      229 - 240
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
      116 - 127
      PROSITE patterns
      PS00010 (ASX_HYDROXYL)
7. IPR013032
   EGF-like, conserved site
   1. PS00022 (EGF_1)
      393 - 404
      PROSITE patterns
      PS00022 (EGF_1)
      276 - 287
      PROSITE patterns
      PS00022 (EGF_1)
      314 - 325
      PROSITE patterns
      PS00022 (EGF_1)
      904 - 915
      PROSITE patterns
      PS00022 (EGF_1)
      238 - 249
      PROSITE patterns
      PS00022 (EGF_1)
      352 - 363
      PROSITE patterns
      PS00022 (EGF_1)
      671 - 682
      PROSITE patterns
      PS00022 (EGF_1)
      507 - 518
      PROSITE patterns
      PS00022 (EGF_1)
      545 - 556
      PROSITE patterns
      PS00022 (EGF_1)
      163 - 174
      PROSITE patterns
      PS00022 (EGF_1)
      125 - 136
      PROSITE patterns
      PS00022 (EGF_1)
      942 - 953
      PROSITE patterns
      PS00022 (EGF_1)
      200 - 211
      PROSITE patterns
      PS00022 (EGF_1)
      469 - 480
      PROSITE patterns
      PS00022 (EGF_1)
      825 - 836
      PROSITE patterns
      PS00022 (EGF_1)
      865 - 876
      PROSITE patterns
      PS00022 (EGF_1)
      88 - 99
      PROSITE patterns
      PS00022 (EGF_1)
      623 - 634
      PROSITE patterns
      PS00022 (EGF_1)
      709 - 720
      PROSITE patterns
      PS00022 (EGF_1)
      747 - 758
      PROSITE patterns
      PS00022 (EGF_1)
      431 - 442
      PROSITE patterns
      PS00022 (EGF_1)
      584 - 595
      PROSITE patterns
      PS00022 (EGF_1)
      785 - 796
      PROSITE patterns
      PS00022 (EGF_1)
      50 - 61
      PROSITE patterns
      PS00022 (EGF_1)
   2. PS01186 (EGF_2)
      623 - 634
      PROSITE patterns
      PS01186 (EGF_2)
      238 - 249
      PROSITE patterns
      PS01186 (EGF_2)
      352 - 363
      PROSITE patterns
      PS01186 (EGF_2)
      200 - 211
      PROSITE patterns
      PS01186 (EGF_2)
      314 - 325
      PROSITE patterns
      PS01186 (EGF_2)
      393 - 404
      PROSITE patterns
      PS01186 (EGF_2)
      276 - 287
      PROSITE patterns
      PS01186 (EGF_2)
      785 - 796
      PROSITE patterns
      PS01186 (EGF_2)
      545 - 556
      PROSITE patterns
      PS01186 (EGF_2)
      671 - 682
      PROSITE patterns
      PS01186 (EGF_2)
      469 - 480
      PROSITE patterns
      PS01186 (EGF_2)
      88 - 99
      PROSITE patterns
      PS01186 (EGF_2)
      865 - 876
      PROSITE patterns
      PS01186 (EGF_2)
      50 - 61
      PROSITE patterns
      PS01186 (EGF_2)
      584 - 595
      PROSITE patterns
      PS01186 (EGF_2)
      125 - 136
      PROSITE patterns
      PS01186 (EGF_2)
      431 - 442
      PROSITE patterns
      PS01186 (EGF_2)
      709 - 720
      PROSITE patterns
      PS01186 (EGF_2)
      507 - 518
      PROSITE patterns
      PS01186 (EGF_2)

no IPR
Unintegrated signatures

1. G3DSA:2.10.25.10
   556 - 592
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   794 - 839
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   653 - 684
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   175 - 209
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   593 - 636
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   16 - 59
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   98 - 135
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   60 - 97
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   517 - 555
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   136 - 174
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   210 - 252
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   478 - 516
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
2. G3DSA:2.170.3...
   367 - 477
   GENE3D
   G3DSA:2.170.300.10 (G3DSA:2.170.300.10)
   687 - 793
   GENE3D
   G3DSA:2.170.300.10 (G3DSA:2.170.300.10)
   843 - 955
   GENE3D
   G3DSA:2.170.300.10 (G3DSA:2.170.300.10)
   254 - 366
   GENE3D
   G3DSA:2.170.300.10 (G3DSA:2.170.300.10)
3. PR00010 (EGFBLOOD)
   541 - 551
   PRINTS
   PR00010 (EGFBLOOD)
   552 - 558
   PRINTS
   PR00010 (EGFBLOOD)
   483 - 494
   PRINTS
   PR00010 (EGFBLOOD)
   533 - 540
   PRINTS
   PR00010 (EGFBLOOD)
4. PR01983 (NOTCH)
   1,041 - 1,059
   PRINTS
   PR01983 (NOTCH)
   459 - 487
   PRINTS
   PR01983 (NOTCH)
5. PTHR24033 (FAMILY N...)
   17 - 1,099
   PANTHER
   PTHR24033 (FAMILY NOT NAMED)
6. PTHR24033:SF3 (SUBF...)
   17 - 1,099
   PANTHER
   PTHR24033:SF3 (SUBFAMILY NOT NAMED)
7. SSF57196 (EGF/Laminin)
   328 - 371
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   652 - 684
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   26 - 69
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   560 - 603
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   599 - 638
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   841 - 878
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   920 - 955
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   761 - 803
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   523 - 563
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   799 - 838
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   882 - 918
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   723 - 765
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
   686 - 727
   SUPERFAMILY
   SSF57196 (EGF/Laminin)

### GO term prediction

#### Biological Process

GO:0030154 cell differentiation

#### Molecular Function

GO:0005509 calcium ion binding
GO:0005515 protein binding

#### Cellular Component

GO:0016020 membrane