Protein

## EMLSAP00000002673

Length
736 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   73 - 299
   - Dbl homology (DH) domain (IPR000219)
   439 - 507
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
     - Zinc finger, FYVE/PHD-type (IPR011011)
       - FYVE zinc finger (IPR000306)
2. Domain
   295 - 416
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
   447 - 506
   - Zinc finger, FYVE-related (IPR017455)
   567 - 706
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)

1 100 200 300 400 500 600 736

### Detailed signature matches

1. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      95 - 279
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      73 - 299
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      95 - 279
      Pfam
      PF00621 (RhoGEF)
   4. PS50010 (DH_2)
      91 - 280
      PROSITE profiles
      PS50010 (DH_2)
   5. G3DSA:1.20.90...
      78 - 294
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
2. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      295 - 415
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
      567 - 703
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
3. IPR001849
   Pleckstrin homology domain
   1. PF00169 (PH)
      311 - 413
      Pfam
      PF00169 (PH)
   2. SM00233 (PH)
      310 - 416
      SMART
      SM00233 (PH)
      568 - 706
      SMART
      SM00233 (PH)
   3. PS50003 (PH_DOMAIN)
      309 - 414
      PROSITE profiles
      PS50003 (PH_DOMAIN)
4. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10
      448 - 507
      GENE3D
      G3DSA:3.30.40.10 (G3DSA:3.30.40.10)
5. IPR011011
   Zinc finger, FYVE/PHD-type
   1. SSF57903 (FYVE/PHD ...)
      444 - 507
      SUPERFAMILY
      SSF57903 (FYVE/PHD zinc finger)
6. IPR000306
   FYVE zinc finger
   1. SM00064 (FYVE)
      439 - 507
      SMART
      SM00064 (FYVE)
   2. PF01363 (FYVE)
      448 - 505
      Pfam
      PF01363 (FYVE)
7. IPR017455
   Zinc finger, FYVE-related
   1. PS50178 (ZF_FYVE)
      447 - 506
      PROSITE profiles
      PS50178 (ZF_FYVE)

no IPR
Unintegrated signatures

1. PTHR12673 (FACIOGEN...)
   1 - 623
   PANTHER
   PTHR12673 (FACIOGENITAL DYSPLASIA PROTEIN)
2. PTHR12673:SF15 (FRA...)
   1 - 623
   PANTHER
   PTHR12673:SF15 (FRABRIN)
3. SSF50729 (PH domain...)
   563 - 646
   SUPERFAMILY
   SSF50729 (PH domain-like)
   675 - 722
   SUPERFAMILY
   SSF50729 (PH domain-like)
   281 - 420
   SUPERFAMILY
   SSF50729 (PH domain-like)

### GO term prediction

#### Biological Process

GO:0035023 regulation of Rho protein signal transduction

#### Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding

#### Cellular Component

None predicted.