Protein

## EMLSAP00000012251

Length
941 amino acids

### Protein family membership

- DNA replication factor C, large subunit (IPR012178)

### Domains and repeats

1. Domain
   238 - 328
   - BRCT domain (IPR001357)
   423 - 665
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
     - AAA+ ATPase domain (IPR003593)
       - ATPase, AAA-type, core (IPR003959)
   802 - 862
   - DNA replication factor RFC1, C-terminal (IPR013725)
2. Domain
   699 - 804
   - DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal (IPR008921)
3. Domain
   766 - 802
   - DNA replication factor RFC1, C-terminal (IPR013725)

1 100 200 300 400 500 600 700 800 941

### Detailed signature matches

1. IPR012178
   DNA replication factor C, large subunit
   1. PIRSF036578 (RFC1)
      1 - 939
      PIRSF
      PIRSF036578 (RFC1)
2. IPR001357
   BRCT domain
   1. SM00292 (BRCT)
      240 - 318
      SMART
      SM00292 (BRCT)
   2. PS50172 (BRCT)
      238 - 328
      PROSITE profiles
      PS50172 (BRCT)
   3. SSF52113 (BRCT domain)
      240 - 318
      SUPERFAMILY
      SSF52113 (BRCT domain)
   4. PF00533 (BRCT)
      241 - 315
      Pfam
      PF00533 (BRCT)
   5. G3DSA:3.40.50...
      240 - 322
      GENE3D
      G3DSA:3.40.50.10190 (G3DSA:3.40.50.10190)
3. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      423 - 665
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
4. IPR003593
   AAA+ ATPase domain
   1. SM00382 (AAA)
      485 - 609
      SMART
      SM00382 (AAA)
5. IPR003959
   ATPase, AAA-type, core
   1. PF00004 (AAA)
      494 - 606
      Pfam
      PF00004 (AAA)
6. IPR008921
   DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
   1. SSF48019 (post-AAA+...)
      699 - 804
      SUPERFAMILY
      SSF48019 (post-AAA+ oligomerization domain-like)
7. IPR013725
   DNA replication factor RFC1, C-terminal
   1. PF08519 (RFC1)
      766 - 802
      Pfam
      PF08519 (RFC1)
      802 - 862
      Pfam
      PF08519 (RFC1)

no IPR
Unintegrated signatures

1. G3DSA:1.10.8.60
   606 - 679
   GENE3D
   G3DSA:1.10.8.60 (G3DSA:1.10.8.60)
2. G3DSA:1.20.27...
   699 - 805
   GENE3D
   G3DSA:1.20.272.10 (G3DSA:1.20.272.10)
3. G3DSA:3.40.50...
   424 - 603
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
4. PTHR11107 (BRCT DOM...)
   85 - 941
   PANTHER
   PTHR11107 (BRCT DOMAIN-CONTAINING PROTEIN)
5. PTHR11107:SF9 (REPL...)
   85 - 941
   PANTHER
   PTHR11107:SF9 (REPLICATION FACTOR C LARGE SUBUNIT)

### GO term prediction

#### Biological Process

GO:0006260 DNA replication

#### Molecular Function

GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity

#### Cellular Component

GO:0005663 DNA replication factor C complex