Protein

## EMLSAP00000005353

Length
2,560 amino acids

### Protein family membership

- GPCR, family 2, secretin-like (IPR000832)

### Domains and repeats

1. Domain
   29 - 947
   - Cadherin-like (IPR015919)
     - Cadherin (IPR002126)
   1,059 - 1,118
   - Epidermal growth factor-like domain (IPR000742)
   1,120 - 1,156
   - Epidermal growth factor-like domain (IPR000742)
   1,163 - 1,201
   - Epidermal growth factor-like domain (IPR000742)
   1,404 - 1,440
   - Epidermal growth factor-like domain (IPR000742)
   1,622 - 1,662
   - Epidermal growth factor-like domain (IPR000742)
   1,682 - 1,717
   - EGF-like, laminin (IPR002049)
   1,718 - 1,770
   - EGF-like, laminin (IPR002049)
   2,142 - 2,384
   - GPCR, family 2-like (IPR017981)
2. Domain
   1,120 - 1,156
   - EGF-like calcium-binding domain (IPR001881)
   1,404 - 1,440
   - EGF-like calcium-binding domain (IPR001881)
3. Domain
   1,176 - 1,200
   - C-type lectin-like (IPR016186)
   1,201 - 1,418
   - Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
     - Laminin G domain (IPR001791)
   1,419 - 1,632
   - Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
     - Laminin G domain (IPR001791)
   1,750 - 1,828
   - GPCR, family 2, extracellular hormone receptor domain (IPR001879)
4. Domain
   1,186 - 1,405
   - Concanavalin A-like lectin/glucanases superfamily (IPR008985)
   1,427 - 1,582
   - Concanavalin A-like lectin/glucanases superfamily (IPR008985)

1 500 1000 1500 2000 2560

### Detailed signature matches

1. IPR000832
   GPCR, family 2, secretin-like
   1. PF00002 (7tm_2)
      2,143 - 2,365
      Pfam
      PF00002 (7tm_2)
2. IPR015919
   Cadherin-like
   1. SSF49313 (Cadherin-...)
      324 - 453
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      113 - 207
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      535 - 637
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      440 - 541
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      640 - 748
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      29 - 125
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      743 - 860
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      850 - 947
      SUPERFAMILY
      SSF49313 (Cadherin-like)
      223 - 336
      SUPERFAMILY
      SSF49313 (Cadherin-like)
3. IPR002126
   Cadherin
   1. SM00112 (CA)
      147 - 227
      SMART
      SM00112 (CA)
      563 - 643
      SMART
      SM00112 (CA)
      777 - 860
      SMART
      SM00112 (CA)
      358 - 444
      SMART
      SM00112 (CA)
      44 - 123
      SMART
      SM00112 (CA)
      460 - 539
      SMART
      SM00112 (CA)
      253 - 334
      SMART
      SM00112 (CA)
      667 - 753
      SMART
      SM00112 (CA)
   2. PF00028 (Cadherin)
      130 - 207
      Pfam
      PF00028 (Cadherin)
      650 - 746
      Pfam
      PF00028 (Cadherin)
      463 - 532
      Pfam
      PF00028 (Cadherin)
      344 - 437
      Pfam
      PF00028 (Cadherin)
      762 - 852
      Pfam
      PF00028 (Cadherin)
      548 - 636
      Pfam
      PF00028 (Cadherin)
      246 - 326
      Pfam
      PF00028 (Cadherin)
   3. PR00205 (CADHERIN)
      425 - 444
      PRINTS
      PR00205 (CADHERIN)
      125 - 154
      PRINTS
      PR00205 (CADHERIN)
      444 - 457
      PRINTS
      PR00205 (CADHERIN)
      67 - 86
      PRINTS
      PR00205 (CADHERIN)
      301 - 313
      PRINTS
      PR00205 (CADHERIN)
      703 - 729
      PRINTS
      PR00205 (CADHERIN)
      737 - 754
      PRINTS
      PR00205 (CADHERIN)
   4. G3DSA:2.60.40.60
      444 - 537
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      753 - 859
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      538 - 642
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      29 - 121
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      227 - 332
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      122 - 226
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      643 - 752
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      333 - 443
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
      860 - 942
      GENE3D
      G3DSA:2.60.40.60 (G3DSA:2.60.40.60)
   5. PS50268 (CADHERIN_2)
      462 - 541
      PROSITE profiles
      PS50268 (CADHERIN_2)
      542 - 645
      PROSITE profiles
      PS50268 (CADHERIN_2)
      646 - 755
      PROSITE profiles
      PS50268 (CADHERIN_2)
      42 - 125
      PROSITE profiles
      PS50268 (CADHERIN_2)
      250 - 336
      PROSITE profiles
      PS50268 (CADHERIN_2)
      126 - 229
      PROSITE profiles
      PS50268 (CADHERIN_2)
      756 - 862
      PROSITE profiles
      PS50268 (CADHERIN_2)
      337 - 446
      PROSITE profiles
      PS50268 (CADHERIN_2)
4. IPR000742
   Epidermal growth factor-like domain
   1. PF00008 (EGF)
      1,124 - 1,154
      Pfam
      PF00008 (EGF)
      1,408 - 1,438
      Pfam
      PF00008 (EGF)
   2. PS50026 (EGF_3)
      1,622 - 1,662
      PROSITE profiles
      PS50026 (EGF_3)
      1,404 - 1,440
      PROSITE profiles
      PS50026 (EGF_3)
      1,120 - 1,156
      PROSITE profiles
      PS50026 (EGF_3)
   3. SM00181 (EGF)
      1,123 - 1,156
      SMART
      SM00181 (EGF)
      1,059 - 1,118
      SMART
      SM00181 (EGF)
      1,407 - 1,440
      SMART
      SM00181 (EGF)
      1,163 - 1,201
      SMART
      SM00181 (EGF)
      1,624 - 1,662
      SMART
      SM00181 (EGF)
5. IPR001881
   EGF-like calcium-binding domain
   1. SM00179 (EGF_CA)
      1,404 - 1,440
      SMART
      SM00179 (EGF_CA)
      1,120 - 1,156
      SMART
      SM00179 (EGF_CA)
6. IPR016186
   C-type lectin-like
   1. G3DSA:3.10.10...
      1,176 - 1,200
      GENE3D
      G3DSA:3.10.100.10 (G3DSA:3.10.100.10)
7. IPR008985
   Concanavalin A-like lectin/glucanases superfamily
   1. SSF49899 (Concanava...)
      1,427 - 1,582
      SUPERFAMILY
      SSF49899 (Concanavalin A-like lectins/glucanases)
      1,186 - 1,405
      SUPERFAMILY
      SSF49899 (Concanavalin A-like lectins/glucanases)
8. IPR013320
   Concanavalin A-like lectin/glucanase, subgroup
   1. G3DSA:2.60.12...
      1,419 - 1,632
      GENE3D
      G3DSA:2.60.120.200 (G3DSA:2.60.120.200)
      1,201 - 1,418
      GENE3D
      G3DSA:2.60.120.200 (G3DSA:2.60.120.200)
9. IPR001791
   Laminin G domain
   1. SM00282 (LamG)
      1,469 - 1,582
      SMART
      SM00282 (LamG)
      1,222 - 1,384
      SMART
      SM00282 (LamG)
   2. PF02210 (Laminin_G_2)
      1,476 - 1,581
      Pfam
      PF02210 (Laminin_G_2)
      1,230 - 1,383
      Pfam
      PF02210 (Laminin_G_2)
   3. PS50025 (LAM_G_DOMAIN)
      1,202 - 1,401
      PROSITE profiles
      PS50025 (LAM_G_DOMAIN)
      1,446 - 1,611
      PROSITE profiles
      PS50025 (LAM_G_DOMAIN)
10. IPR002049
    EGF-like, laminin
    1. PS01248 (EGF_LAM_1)
       1,737 - 1,770
       PROSITE patterns
       PS01248 (EGF_LAM_1)
    2. SM00180 (EGF_Lam)
       1,718 - 1,763
       SMART
       SM00180 (EGF_Lam)
    3. PF00053 (Laminin_EGF)
       1,718 - 1,758
       Pfam
       PF00053 (Laminin_EGF)
    4. PS50027 (EGF_LAM_2)
       1,682 - 1,717
       PROSITE profiles
       PS50027 (EGF_LAM_2)
       1,718 - 1,765
       PROSITE profiles
       PS50027 (EGF_LAM_2)
11. IPR001879
    GPCR, family 2, extracellular hormone receptor domain
    1. SM00008 (HormR)
       1,766 - 1,828
       SMART
       SM00008 (HormR)
    2. PS50227 (G_PROTEIN_...)
       1,750 - 1,823
       PROSITE profiles
       PS50227 (G_PROTEIN_RECEP_F2_3)
12. IPR017981
    GPCR, family 2-like
    1. PS50261 (G_PROTEIN_...)
       2,142 - 2,384
       PROSITE profiles
       PS50261 (G_PROTEIN_RECEP_F2_4)
13. IPR020894
    Cadherin conserved site
    1. PS00232 (CADHERIN_1)
       434 - 444
       PROSITE patterns
       PS00232 (CADHERIN_1)
       633 - 643
       PROSITE patterns
       PS00232 (CADHERIN_1)
       850 - 860
       PROSITE patterns
       PS00232 (CADHERIN_1)
       324 - 334
       PROSITE patterns
       PS00232 (CADHERIN_1)
       217 - 227
       PROSITE patterns
       PS00232 (CADHERIN_1)
       743 - 753
       PROSITE patterns
       PS00232 (CADHERIN_1)
       113 - 123
       PROSITE patterns
       PS00232 (CADHERIN_1)
14. IPR013032
    EGF-like, conserved site
    1. PS00022 (EGF_1)
       1,737 - 1,748
       PROSITE patterns
       PS00022 (EGF_1)
       1,428 - 1,439
       PROSITE patterns
       PS00022 (EGF_1)
       1,144 - 1,155
       PROSITE patterns
       PS00022 (EGF_1)

no IPR
Unintegrated signatures

1. G3DSA:2.10.25.10
   1,716 - 1,763
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   1,121 - 1,157
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   1,056 - 1,111
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
2. PR00011 (EGFLAMININ)
   1,421 - 1,439
   PRINTS
   PR00011 (EGFLAMININ)
   1,730 - 1,748
   PRINTS
   PR00011 (EGFLAMININ)
   1,701 - 1,729
   PRINTS
   PR00011 (EGFLAMININ)
   1,137 - 1,155
   PRINTS
   PR00011 (EGFLAMININ)
3. PTHR24026 (FAMILY N...)
   27 - 2,529
   PANTHER
   PTHR24026 (FAMILY NOT NAMED)
4. PTHR24026:SF29 (SUB...)
   27 - 2,529
   PANTHER
   PTHR24026:SF29 (SUBFAMILY NOT NAMED)
5. SSF111418 (Hormone ...)
   1,769 - 1,822
   SUPERFAMILY
   SSF111418 (Hormone receptor domain)
6. SSF57196 (EGF/Laminin)
   1,117 - 1,158
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
7. TMhelix
   2,182 - 2,204
   TMHMM
   TMhelix (TMhelix)
   2,294 - 2,316
   TMHMM
   TMhelix (TMhelix)
   2,329 - 2,351
   TMHMM
   TMhelix (TMhelix)
   2,214 - 2,236
   TMHMM
   TMhelix (TMhelix)
   2,257 - 2,279
   TMHMM
   TMhelix (TMhelix)
   2,148 - 2,170
   TMHMM
   TMhelix (TMhelix)
   2,361 - 2,383
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

#### Molecular Function

GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding

#### Cellular Component

GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane