Protein

## EMLSAP00000008460

Length
1,303 amino acids

### Protein family membership

- Phosphoinositide phospholipase C family (IPR001192)

### Domains and repeats

1. Domain
   21 - 153
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
   194 - 229
   - EF-hand domain (IPR002048)
   243 - 262
   - EF-hand domain (IPR002048)
   312 - 457
   - Phospholipase C, phosphatidylinositol-specific , X domain (IPR000909)
   484 - 545
   - Pleckstrin homology-like domain (IPR011993)
   806 - 875
   - Src homology-3 domain (IPR001452)
   920 - 964
   - Pleckstrin homology-like domain (IPR011993)
   984 - 1,102
   - Phospholipase C, phosphatidylinositol-specific, Y domain (IPR001711)
2. Domain
   156 - 304
   - EF-hand domain pair (IPR011992)
     - Phospholipase C, phosphoinositol-specific, EF-hand-like (IPR015359)
   311 - 472
   - PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (IPR017946)
   561 - 666
   - SH2 domain (IPR000980)
   667 - 764
   - SH2 domain (IPR000980)
   939 - 1,106
   - PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (IPR017946)
   1,121 - 1,244
   - C2 domain (IPR000008)

1 200 400 600 800 1000 1200 1303

### Detailed signature matches

1. IPR001192
   Phosphoinositide phospholipase C family
   1. PR00390 (PHPHLIPASEC)
      440 - 457
      PRINTS
      PR00390 (PHPHLIPASEC)
      343 - 363
      PRINTS
      PR00390 (PHPHLIPASEC)
      1,061 - 1,079
      PRINTS
      PR00390 (PHPHLIPASEC)
      1,040 - 1,061
      PRINTS
      PR00390 (PHPHLIPASEC)
      317 - 335
      PRINTS
      PR00390 (PHPHLIPASEC)
      1,212 - 1,222
      PRINTS
      PR00390 (PHPHLIPASEC)
   2. PTHR10336 (PHOSPHOI...)
      4 - 1,272
      PANTHER
      PTHR10336 (PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN)
2. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      484 - 545
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
      920 - 964
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
      41 - 153
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
3. IPR001849
   Pleckstrin homology domain
   1. SM00233 (PH)
      21 - 149
      SMART
      SM00233 (PH)
   2. PS50003 (PH_DOMAIN)
      33 - 147
      PROSITE profiles
      PS50003 (PH_DOMAIN)
4. IPR011992
   EF-hand domain pair
   1. G3DSA:1.10.23...
      156 - 301
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
5. IPR002048
   EF-hand domain
   1. PS50222 (EF_HAND_2)
      194 - 229
      PROSITE profiles
      PS50222 (EF_HAND_2)
      243 - 262
      PROSITE profiles
      PS50222 (EF_HAND_2)
6. IPR015359
   Phospholipase C, phosphoinositol-specific, EF-hand-like
   1. PF09279 (EF-hand_like)
      234 - 304
      Pfam
      PF09279 (EF-hand_like)
7. IPR017946
   PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
   1. G3DSA:3.20.20...
      311 - 458
      GENE3D
      G3DSA:3.20.20.190 (G3DSA:3.20.20.190)
      980 - 1,106
      GENE3D
      G3DSA:3.20.20.190 (G3DSA:3.20.20.190)
   2. SSF51695 (PLC-like ...)
      312 - 472
      SUPERFAMILY
      SSF51695 (PLC-like phosphodiesterases)
      939 - 1,103
      SUPERFAMILY
      SSF51695 (PLC-like phosphodiesterases)
8. IPR000909
   Phospholipase C, phosphatidylinositol-specific , X domain
   1. PF00388 (PI-PLC-X)
      314 - 457
      Pfam
      PF00388 (PI-PLC-X)
   2. PS50007 (PIPLC_X_DO...)
      312 - 456
      PROSITE profiles
      PS50007 (PIPLC_X_DOMAIN)
   3. SM00148 (PLCXc)
      312 - 456
      SMART
      SM00148 (PLCXc)
9. IPR000980
   SH2 domain
   1. PF00017 (SH2)
      675 - 749
      Pfam
      PF00017 (SH2)
      563 - 646
      Pfam
      PF00017 (SH2)
   2. PR00401 (SH2DOMAIN)
      675 - 689
      PRINTS
      PR00401 (SH2DOMAIN)
      695 - 705
      PRINTS
      PR00401 (SH2DOMAIN)
      738 - 752
      PRINTS
      PR00401 (SH2DOMAIN)
      707 - 718
      PRINTS
      PR00401 (SH2DOMAIN)
   3. PS50001 (SH2)
      563 - 664
      PROSITE profiles
      PS50001 (SH2)
      675 - 764
      PROSITE profiles
      PS50001 (SH2)
   4. G3DSA:3.30.50...
      667 - 762
      GENE3D
      G3DSA:3.30.505.10 (G3DSA:3.30.505.10)
      561 - 666
      GENE3D
      G3DSA:3.30.505.10 (G3DSA:3.30.505.10)
   5. SM00252 (SH2)
      561 - 652
      SMART
      SM00252 (SH2)
      673 - 755
      SMART
      SM00252 (SH2)
10. IPR001452
    Src homology-3 domain
    1. SM00326 (SH3)
       809 - 865
       SMART
       SM00326 (SH3)
    2. SSF50044 (SH3-domain)
       807 - 875
       SUPERFAMILY
       SSF50044 (SH3-domain)
    3. PS50002 (SH3)
       806 - 866
       PROSITE profiles
       PS50002 (SH3)
11. IPR001711
    Phospholipase C, phosphatidylinositol-specific, Y domain
    1. PS50008 (PIPLC_Y_DO...)
       985 - 1,101
       PROSITE profiles
       PS50008 (PIPLC_Y_DOMAIN)
    2. PF00387 (PI-PLC-Y)
       984 - 1,101
       Pfam
       PF00387 (PI-PLC-Y)
    3. SM00149 (PLCYc)
       985 - 1,102
       SMART
       SM00149 (PLCYc)
12. IPR000008
    C2 domain
    1. PF00168 (C2)
       1,123 - 1,210
       Pfam
       PF00168 (C2)
    2. PS50004 (C2)
       1,123 - 1,211
       PROSITE profiles
       PS50004 (C2)
    3. SSF49562 (C2 domain...)
       1,121 - 1,244
       SUPERFAMILY
       SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
    4. SM00239 (C2)
       1,122 - 1,226
       SMART
       SM00239 (C2)
13. IPR018247
    EF-Hand 1, calcium-binding site
    1. PS00018 (EF_HAND_1)
       207 - 219
       PROSITE patterns
       PS00018 (EF_HAND_1)

no IPR
Unintegrated signatures

1. Coil
   968 - 989
   COILS
   Coil (Coil)
2. G3DSA:2.30.30.40
   808 - 879
   GENE3D
   G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
3. G3DSA:2.60.40...
   1,120 - 1,245
   GENE3D
   G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
4. PF14604 (SH3_9)
   813 - 861
   Pfam
   PF14604 (SH3_9)
5. PTHR10336:SF55 (1-P...)
   4 - 1,272
   PANTHER
   PTHR10336:SF55 (1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE)
6. SSF47473 (EF-hand)
   176 - 304
   SUPERFAMILY
   SSF47473 (EF-hand)
7. SSF50729 (PH domain...)
   41 - 146
   SUPERFAMILY
   SSF50729 (PH domain-like)
8. SSF55550 (SH2 domain)
   554 - 650
   SUPERFAMILY
   SSF55550 (SH2 domain)
   660 - 762
   SUPERFAMILY
   SSF55550 (SH2 domain)

### GO term prediction

#### Biological Process

GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

#### Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity

#### Cellular Component

None predicted.