Protein

## EMLSAP00000010235

Length
464 amino acids

### Protein family membership

- NADH-quinone oxidoreductase, chain I (IPR010226)

### Domains and repeats

1. Domain
   95 - 163
   - 4Fe-4S ferredoxin-type, iron-sulphur binding domain (IPR017896)
     - 4Fe-4S binding domain (IPR001450)
   185 - 430
   - WD40/YVTN repeat-like-containing domain (IPR015943)
     - WD40-repeat-containing domain (IPR017986)
2. Domain
   423 - 464
   - SOCS protein, C-terminal (IPR001496)
3. Repeat
   185 - 237
   - WD40 repeat (IPR001680)
   277 - 325
   - WD40 repeat (IPR001680)
4. Repeat
   236 - 271
   - WD40 repeat (IPR001680)
   323 - 370
   - WD40 repeat (IPR001680)

1 50 100 150 200 250 300 350 400 464

### Detailed signature matches

1. IPR010226
   NADH-quinone oxidoreductase, chain I
   1. TIGR01971
      60 - 181
      UNKNOWN
      TIGR01971 (TIGR01971)
   2. MF_01351 (NDH1_NuoI)
      51 - 187
      HAMAP
      MF_01351 (NDH1_NuoI)
2. IPR017896
   4Fe-4S ferredoxin-type, iron-sulphur binding domain
   1. PS51379 (4FE4S_FER_2)
      134 - 163
      PROSITE profiles
      PS51379 (4FE4S_FER_2)
      95 - 124
      PROSITE profiles
      PS51379 (4FE4S_FER_2)
3. IPR001450
   4Fe-4S binding domain
   1. PF12838 (Fer4_7)
      103 - 157
      Pfam
      PF12838 (Fer4_7)
4. IPR015943
   WD40/YVTN repeat-like-containing domain
   1. G3DSA:2.130.1...
      187 - 430
      GENE3D
      G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
5. IPR017986
   WD40-repeat-containing domain
   1. SSF50978 (WD40 repe...)
      185 - 418
      SUPERFAMILY
      SSF50978 (WD40 repeat-like)
   2. PS50294 (WD_REPEATS...)
      192 - 325
      PROSITE profiles
      PS50294 (WD_REPEATS_REGION)
6. IPR001496
   SOCS protein, C-terminal
   1. PF07525 (SOCS_box)
      424 - 461
      Pfam
      PF07525 (SOCS_box)
   2. PS50225 (SOCS)
      423 - 464
      PROSITE profiles
      PS50225 (SOCS)
   3. SM00969 (SOCS_box)
      424 - 461
      SMART
      SM00969 (SOCS_box)
7. IPR001680
   WD40 repeat
   1. PS50082 (WD_REPEATS_2)
      284 - 325
      PROSITE profiles
      PS50082 (WD_REPEATS_2)
      192 - 237
      PROSITE profiles
      PS50082 (WD_REPEATS_2)
   2. SM00320 (WD40)
      277 - 316
      SMART
      SM00320 (WD40)
      185 - 228
      SMART
      SM00320 (WD40)
      236 - 271
      SMART
      SM00320 (WD40)
      323 - 370
      SMART
      SM00320 (WD40)
   3. PF00400 (WD40)
      280 - 316
      Pfam
      PF00400 (WD40)
      188 - 228
      Pfam
      PF00400 (WD40)
      247 - 267
      Pfam
      PF00400 (WD40)
8. IPR017900
   4Fe-4S ferredoxin, iron-sulphur binding, conserved site
   1. PS00198 (4FE4S_FER_1)
      143 - 154
      PROSITE patterns
      PS00198 (4FE4S_FER_1)
      104 - 115
      PROSITE patterns
      PS00198 (4FE4S_FER_1)
9. IPR019775
   WD40 repeat, conserved site
   1. PS00678 (WD_REPEATS_1)
      303 - 317
      PROSITE patterns
      PS00678 (WD_REPEATS_1)

no IPR
Unintegrated signatures

1. G3DSA:1.10.10...
   57 - 180
   GENE3D
   G3DSA:1.10.1060.10 (G3DSA:1.10.1060.10)
2. PTHR10849 (NADH DEH...)
   28 - 186
   PANTHER
   PTHR10849 (NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL)
3. PTHR10849:SF4 (NADH...)
   28 - 186
   PANTHER
   PTHR10849:SF4 (NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL)
4. SSF158235 (SOCS box...)
   418 - 462
   SUPERFAMILY
   SSF158235 (SOCS box-like)
5. SSF54862 (4Fe-4S fe...)
   77 - 187
   SUPERFAMILY
   SSF54862 (4Fe-4S ferredoxins)

### GO term prediction

#### Biological Process

GO:0035556 intracellular signal transduction
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0005515 protein binding
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding

#### Cellular Component

GO:0016020 membrane