Protein

## EMLSAP00000000229

Length
917 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   10 - 156
   - ENTH/VHS (IPR008942)
     - VHS (IPR002014)
       - VHS subgroup (IPR018205)
   490 - 615
   - Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (IPR008152)
   725 - 859
   - Mur ligase, C-terminal (IPR004101)
   875 - 913
   - Mur ligase, C-terminal (IPR004101)
2. Domain
   178 - 303
   - GAT (IPR004152)
   479 - 615
   - Coatomer/clathrin adaptor appendage, Ig-like subdomain (IPR013041)
     - Clathrin adaptor, gamma-adaptin, appendage (IPR008153)
3. Domain
   611 - 739
   - Mur ligase, central (IPR013221)

1 100 200 300 400 500 600 700 800 917

### Detailed signature matches

1. IPR008942
   ENTH/VHS
   1. G3DSA:1.25.40.90
      10 - 152
      GENE3D
      G3DSA:1.25.40.90 (G3DSA:1.25.40.90)
   2. SSF48464 (ENTH/VHS ...)
      15 - 156
      SUPERFAMILY
      SSF48464 (ENTH/VHS domain)
2. IPR002014
   VHS
   1. PF00790 (VHS)
      14 - 150
      Pfam
      PF00790 (VHS)
   2. PS50179 (VHS)
      22 - 154
      PROSITE profiles
      PS50179 (VHS)
3. IPR018205
   VHS subgroup
   1. SM00288 (VHS)
      15 - 150
      SMART
      SM00288 (VHS)
4. IPR004152
   GAT
   1. PF03127 (GAT)
      214 - 303
      Pfam
      PF03127 (GAT)
   2. PS50909 (GAT)
      178 - 303
      PROSITE profiles
      PS50909 (GAT)
5. IPR013041
   Coatomer/clathrin adaptor appendage, Ig-like subdomain
   1. SSF49348 (Clathrin ...)
      479 - 613
      SUPERFAMILY
      SSF49348 (Clathrin adaptor appendage domain)
6. IPR008153
   Clathrin adaptor, gamma-adaptin, appendage
   1. PS50180 (GAE)
      494 - 615
      PROSITE profiles
      PS50180 (GAE)
   2. G3DSA:2.60.40...
      479 - 609
      GENE3D
      G3DSA:2.60.40.1230 (G3DSA:2.60.40.1230)
7. IPR008152
   Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
   1. PF02883 (Alpha_adap...)
      503 - 609
      Pfam
      PF02883 (Alpha_adaptinC2)
   2. SM00809 (Alpha_adap...)
      490 - 615
      SMART
      SM00809 (Alpha_adaptinC2)
8. IPR013221
   Mur ligase, central
   1. G3DSA:3.40.11...
      611 - 726
      GENE3D
      G3DSA:3.40.1190.10 (G3DSA:3.40.1190.10)
   2. SSF53623 (MurD-like...)
      611 - 739
      SUPERFAMILY
      SSF53623 (MurD-like peptide ligases, catalytic domain)
9. IPR004101
   Mur ligase, C-terminal
   1. G3DSA:3.90.19...
      894 - 913
      GENE3D
      G3DSA:3.90.190.20 (G3DSA:3.90.190.20)
      727 - 859
      GENE3D
      G3DSA:3.90.190.20 (G3DSA:3.90.190.20)
   2. SSF53244 (MurD-like...)
      875 - 911
      SUPERFAMILY
      SSF53244 (MurD-like peptide ligases, peptide-binding domain)
      725 - 826
      SUPERFAMILY
      SSF53244 (MurD-like peptide ligases, peptide-binding domain)
   3. PF02875 (Mur_ligase_C)
      725 - 800
      Pfam
      PF02875 (Mur_ligase_C)

no IPR
Unintegrated signatures

1. Coil
   255 - 276
   COILS
   Coil (Coil)
2. G3DSA:1.20.5.170
   178 - 207
   GENE3D
   G3DSA:1.20.5.170 (G3DSA:1.20.5.170)
3. G3DSA:1.20.58...
   208 - 302
   GENE3D
   G3DSA:1.20.58.160 (G3DSA:1.20.58.160)
4. PTHR13856 (VHS DOMA...)
   4 - 609
   PANTHER
   PTHR13856 (VHS DOMAIN CONTAINING PROTEIN FAMILY)
5. PTHR13856:SF36 (GOL...)
   4 - 609
   PANTHER
   PTHR13856:SF36 (GOLGI ASSOCIATED, GAMMA ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN 1 (GGA1))
6. SSF89009 (GAT-like ...)
   179 - 302
   SUPERFAMILY
   SSF89009 (GAT-like domain)

### GO term prediction

#### Biological Process

GO:0006886 intracellular protein transport
GO:0009058 biosynthetic process
GO:0016192 vesicle-mediated transport

#### Molecular Function

GO:0005524 ATP binding
GO:0016874 ligase activity

#### Cellular Component

GO:0005622 intracellular
GO:0030131 clathrin adaptor complex