Protein

## EMLSAP00000010574

Length
785 amino acids

### Protein family membership

- Threonine-tRNA ligase, class IIa (IPR002320)

### Domains and repeats

1. Domain
   2 - 70
   - Glutathione S-transferase, C-terminal-like (IPR010987)
   120 - 184
   - Beta-grasp domain (IPR012675)
     - TGS-like (IPR012676)
       - TGS (IPR004095)
   315 - 364
   - Threonyl/alanyl tRNA synthetase, SAD (IPR012947)
   418 - 580
   - Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain (IPR002314)
   714 - 776
   - Anticodon-binding (IPR004154)
2. Domain
   218 - 386
   - Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain (IPR018163)
   413 - 720
   - Aminoacyl-tRNA synthetase, class II (IPR006195)

1 100 200 300 400 500 600 700 785

### Detailed signature matches

1. IPR002320
   Threonine-tRNA ligase, class IIa
   1. PR01047 (TRNASYNTHTHR)
      474 - 502
      PRINTS
      PR01047 (TRNASYNTHTHR)
      678 - 690
      PRINTS
      PR01047 (TRNASYNTHTHR)
      507 - 530
      PRINTS
      PR01047 (TRNASYNTHTHR)
      608 - 636
      PRINTS
      PR01047 (TRNASYNTHTHR)
      651 - 664
      PRINTS
      PR01047 (TRNASYNTHTHR)
   2. TIGR00418
      221 - 684
      UNKNOWN
      TIGR00418 (TIGR00418)
   3. MF_00184 (Thr_tRNA_...)
      215 - 785
      HAMAP
      MF_00184 (Thr_tRNA_synth)
2. IPR010987
   Glutathione S-transferase, C-terminal-like
   1. SSF47616 (GST C-ter...)
      2 - 56
      SUPERFAMILY
      SSF47616 (GST C-terminal domain-like)
   2. G3DSA:1.20.10...
      3 - 70
      GENE3D
      G3DSA:1.20.1050.10 (G3DSA:1.20.1050.10)
3. IPR012675
   Beta-grasp domain
   1. G3DSA:3.10.20.30
      120 - 184
      GENE3D
      G3DSA:3.10.20.30 (G3DSA:3.10.20.30)
4. IPR012676
   TGS-like
   1. SSF81271 (TGS-like)
      121 - 181
      SUPERFAMILY
      SSF81271 (TGS-like)
5. IPR004095
   TGS
   1. PF02824 (TGS)
      121 - 181
      Pfam
      PF02824 (TGS)
6. IPR018163
   Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
   1. SSF55186 (ThrRS/Ala...)
      218 - 386
      SUPERFAMILY
      SSF55186 (ThrRS/AlaRS common domain)
7. IPR012947
   Threonyl/alanyl tRNA synthetase, SAD
   1. PF07973 (tRNA_SAD)
      316 - 364
      Pfam
      PF07973 (tRNA_SAD)
   2. SM00863 (tRNA_SAD)
      315 - 364
      SMART
      SM00863 (tRNA_SAD)
8. IPR006195
   Aminoacyl-tRNA synthetase, class II
   1. PS50862 (AA_TRNA_LI...)
      413 - 720
      PROSITE profiles
      PS50862 (AA_TRNA_LIGASE_II)
9. IPR002314
   Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
   1. PF00587 (tRNA-synt_2b)
      418 - 580
      Pfam
      PF00587 (tRNA-synt_2b)
10. IPR004154
    Anticodon-binding
    1. PF03129 (HGTP_antic...)
       715 - 776
       Pfam
       PF03129 (HGTP_anticodon)
    2. SSF52954 (Class II ...)
       714 - 776
       SUPERFAMILY
       SSF52954 (Class II aaRS ABD-related)
    3. G3DSA:3.40.50...
       714 - 776
       GENE3D
       G3DSA:3.40.50.800 (G3DSA:3.40.50.800)

no IPR
Unintegrated signatures

1. Coil
   715 - 716
   COILS
   Coil (Coil)
2. G3DSA:3.30.54.20
   278 - 332
   GENE3D
   G3DSA:3.30.54.20 (G3DSA:3.30.54.20)
3. G3DSA:3.30.93...
   387 - 673
   GENE3D
   G3DSA:3.30.930.10 (G3DSA:3.30.930.10)
4. G3DSA:3.30.98...
   333 - 369
   GENE3D
   G3DSA:3.30.980.10 (G3DSA:3.30.980.10)
   217 - 277
   GENE3D
   G3DSA:3.30.980.10 (G3DSA:3.30.980.10)
5. PTHR11451 (TRNA SYN...)
   121 - 774
   PANTHER
   PTHR11451 (TRNA SYNTHETASE-RELATED)
6. PTHR11451:SF5 (THRE...)
   121 - 774
   PANTHER
   PTHR11451:SF5 (THREONYL-TRNA SYNTHETASE)
7. SSF55681 (Class II ...)
   388 - 669
   SUPERFAMILY
   SSF55681 (Class II aaRS and biotin synthetases)

### GO term prediction

#### Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006435 threonyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation

#### Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004829 threonine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds

#### Cellular Component

GO:0005737 cytoplasm