Protein

## EMLSAP00000007028

Length
1,138 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   352 - 567
   - Dbl homology (DH) domain (IPR000219)
2. Domain
   566 - 745
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
   766 - 897
   - C2 domain (IPR000008)
   918 - 1,129
   - Rho GTPase activation protein (IPR008936)
     - Rho GTPase-activating protein domain (IPR000198)

1 200 400 600 800 1000 1138

### Detailed signature matches

1. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      368 - 566
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      352 - 565
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      368 - 565
      Pfam
      PF00621 (RhoGEF)
   4. PS50010 (DH_2)
      364 - 567
      PROSITE profiles
      PS50010 (DH_2)
   5. G3DSA:1.20.90...
      358 - 565
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
2. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      566 - 647
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
      709 - 745
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
3. IPR001849
   Pleckstrin homology domain
   1. SM00233 (PH)
      583 - 744
      SMART
      SM00233 (PH)
   2. PS50003 (PH_DOMAIN)
      582 - 742
      PROSITE profiles
      PS50003 (PH_DOMAIN)
4. IPR000008
   C2 domain
   1. PF00168 (C2)
      766 - 869
      Pfam
      PF00168 (C2)
   2. SSF49562 (C2 domain...)
      792 - 893
      SUPERFAMILY
      SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
   3. SM00239 (C2)
      795 - 897
      SMART
      SM00239 (C2)
5. IPR008936
   Rho GTPase activation protein
   1. SSF48350 (GTPase ac...)
      926 - 1,095
      SUPERFAMILY
      SSF48350 (GTPase activation domain, GAP)
6. IPR000198
   Rho GTPase-activating protein domain
   1. SM00324 (RhoGAP)
      940 - 1,126
      SMART
      SM00324 (RhoGAP)
   2. G3DSA:1.10.55...
      918 - 1,096
      GENE3D
      G3DSA:1.10.555.10 (G3DSA:1.10.555.10)
   3. PF00620 (RhoGAP)
      943 - 1,093
      Pfam
      PF00620 (RhoGAP)
   4. PS50238 (RHOGAP)
      929 - 1,129
      PROSITE profiles
      PS50238 (RHOGAP)
7. IPR001331
   Guanine-nucleotide dissociation stimulator, CDC24, conserved site
   1. PS00741 (DH_1)
      515 - 540
      PROSITE patterns
      PS00741 (DH_1)

no IPR
Unintegrated signatures

1. Coil
   37 - 65
   COILS
   Coil (Coil)
   655 - 676
   COILS
   Coil (Coil)
2. G3DSA:2.60.40...
   794 - 896
   GENE3D
   G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
3. PTHR23182 (BREAKPOI...)
   313 - 1,122
   PANTHER
   PTHR23182 (BREAKPOINT CLUSTER REGION PROTEIN (BCR))
4. PTHR23182:SF0 (SUBF...)
   313 - 1,122
   PANTHER
   PTHR23182:SF0 (SUBFAMILY NOT NAMED)
5. SSF50729 (PH domain...)
   710 - 740
   SUPERFAMILY
   SSF50729 (PH domain-like)
   580 - 650
   SUPERFAMILY
   SSF50729 (PH domain-like)

### GO term prediction

#### Biological Process

GO:0007165 signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction

#### Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

#### Cellular Component

GO:0005622 intracellular