Protein

## EMLSAP00000005203

Length
965 amino acids

### Protein family membership

- Alanine-tRNA ligase, class IIc (IPR002318)
  - Alanine-tRNA ligase, eukaryota/bacteria (IPR023033)

### Domains and repeats

1. Domain
   5 - 769
   - Alanyl-tRNA synthetase, class IIc, core domain (IPR018165)
   889 - 955
   - Phosphoesterase, DHHA1 (IPR003156)
2. Domain
   9 - 597
   - Alanyl-tRNA synthetase, class IIc, N-terminal (IPR018164)
   697 - 756
   - Threonyl/alanyl tRNA synthetase, SAD (IPR012947)
3. Domain
   260 - 464
   - Alanine-tRNA ligase, class IIc, anti-codon-binding domain (IPR018162)
   516 - 595
   - Translation protein, beta-barrel domain (IPR009000)
   599 - 763
   - Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain (IPR018163)

1 100 200 300 400 500 600 700 800 900 965

### Detailed signature matches

1. IPR002318
   Alanine-tRNA ligase, class IIc
   1. TIGR00344
      9 - 942
      UNKNOWN
      TIGR00344 (TIGR00344)
   2. PR00980 (TRNASYNTHALA)
      322 - 335
      PRINTS
      PR00980 (TRNASYNTHALA)
      298 - 314
      PRINTS
      PR00980 (TRNASYNTHALA)
      240 - 253
      PRINTS
      PR00980 (TRNASYNTHALA)
      213 - 224
      PRINTS
      PR00980 (TRNASYNTHALA)
      84 - 95
      PRINTS
      PR00980 (TRNASYNTHALA)
   3. PTHR11777:SF6 (SUBF...)
      1 - 965
      PANTHER
      PTHR11777:SF6 (SUBFAMILY NOT NAMED)
2. IPR023033
   Alanine-tRNA ligase, eukaryota/bacteria
   1. MF_00036_B (Ala_tRN...)
      1 - 964
      HAMAP
      MF_00036_B (Ala_tRNA_synth_B)
3. IPR018165
   Alanyl-tRNA synthetase, class IIc, core domain
   1. PS50860 (AA_TRNA_LI...)
      5 - 769
      PROSITE profiles
      PS50860 (AA_TRNA_LIGASE_II_ALA)
4. IPR018164
   Alanyl-tRNA synthetase, class IIc, N-terminal
   1. PF01411 (tRNA-synt_2c)
      9 - 597
      Pfam
      PF01411 (tRNA-synt_2c)
5. IPR018162
   Alanine-tRNA ligase, class IIc, anti-codon-binding domain
   1. SSF101353 (Putative...)
      260 - 464
      SUPERFAMILY
      SSF101353 (Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS))
6. IPR009000
   Translation protein, beta-barrel domain
   1. SSF50447 (Translati...)
      516 - 595
      SUPERFAMILY
      SSF50447 (Translation proteins)
7. IPR018163
   Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
   1. SSF55186 (ThrRS/Ala...)
      599 - 763
      SUPERFAMILY
      SSF55186 (ThrRS/AlaRS common domain)
8. IPR012947
   Threonyl/alanyl tRNA synthetase, SAD
   1. PF07973 (tRNA_SAD)
      697 - 755
      Pfam
      PF07973 (tRNA_SAD)
   2. SM00863 (tRNA_SAD)
      697 - 756
      SMART
      SM00863 (tRNA_SAD)
9. IPR003156
   Phosphoesterase, DHHA1
   1. PF02272 (DHHA1)
      889 - 955
      Pfam
      PF02272 (DHHA1)

no IPR
Unintegrated signatures

1. Coil
   815 - 836
   COILS
   Coil (Coil)
2. G3DSA:3.30.93...
   5 - 255
   GENE3D
   G3DSA:3.30.930.10 (G3DSA:3.30.930.10)
3. PTHR11777 (ALANYL-T...)
   1 - 965
   PANTHER
   PTHR11777 (ALANYL-TRNA SYNTHETASE)
4. SSF55681 (Class II ...)
   6 - 259
   SUPERFAMILY
   SSF55681 (Class II aaRS and biotin synthetases)

### GO term prediction

#### Biological Process

GO:0006419 alanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation

#### Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds

#### Cellular Component

GO:0005737 cytoplasm