Protein

## EMLSAP00000005778

Length
2,635 amino acids

### Protein family membership

- Neurofibromin (IPR028553)

### Domains and repeats

1. Domain
   372 - 438
   - Armadillo-type fold (IPR016024)
   479 - 640
   - Armadillo-type fold (IPR016024)
   799 - 847
   - Armadillo-type fold (IPR016024)
   989 - 1,162
   - Armadillo-type fold (IPR016024)
   1,262 - 1,274
   - Armadillo-type fold (IPR016024)
   1,302 - 1,345
   - Armadillo-type fold (IPR016024)
2. Domain
   1,149 - 1,506
   - Rho GTPase activation protein (IPR008936)
     - Ras GTPase-activating protein (IPR001936)
   1,548 - 1,681
   - CRAL-TRIO domain (IPR001251)

1 500 1000 1500 2000 2635

### Detailed signature matches

1. IPR028553
   Neurofibromin
   1. PTHR10194:SF7 (NEUR...)
      194 - 2,595
      PANTHER
      PTHR10194:SF7 (NEUROFIBROMIN)
2. IPR016024
   Armadillo-type fold
   1. SSF48371 (ARM repeat)
      1,262 - 1,274
      SUPERFAMILY
      SSF48371 (ARM repeat)
      989 - 1,162
      SUPERFAMILY
      SSF48371 (ARM repeat)
      372 - 438
      SUPERFAMILY
      SSF48371 (ARM repeat)
      799 - 847
      SUPERFAMILY
      SSF48371 (ARM repeat)
      479 - 640
      SUPERFAMILY
      SSF48371 (ARM repeat)
      1,302 - 1,345
      SUPERFAMILY
      SSF48371 (ARM repeat)
3. IPR008936
   Rho GTPase activation protein
   1. SSF48350 (GTPase ac...)
      1,173 - 1,498
      SUPERFAMILY
      SSF48350 (GTPase activation domain, GAP)
4. IPR001936
   Ras GTPase-activating protein
   1. PF00616 (RasGAP)
      1,222 - 1,399
      Pfam
      PF00616 (RasGAP)
   2. SM00323 (RasGAP)
      1,149 - 1,506
      SMART
      SM00323 (RasGAP)
   3. PS50018 (RAS_GTPASE...)
      1,201 - 1,399
      PROSITE profiles
      PS50018 (RAS_GTPASE_ACTIV_2)
   4. G3DSA:1.10.50...
      1,262 - 1,435
      GENE3D
      G3DSA:1.10.506.10 (G3DSA:1.10.506.10)
5. IPR001251
   CRAL-TRIO domain
   1. PF13716 (CRAL_TRIO_2)
      1,548 - 1,681
      Pfam
      PF13716 (CRAL_TRIO_2)

no IPR
Unintegrated signatures

1. G3DSA:1.10.49...
   1,165 - 1,261
   GENE3D
   G3DSA:1.10.494.10 (G3DSA:1.10.494.10)
2. PTHR10194 (RAS GTPA...)
   194 - 2,595
   PANTHER
   PTHR10194 (RAS GTPASE-ACTIVATING PROTEINS)

### GO term prediction

#### Biological Process

GO:0007165 signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction

#### Molecular Function

GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005488 binding

#### Cellular Component

GO:0005622 intracellular