Protein

## EMLSAP00000005755

Length
1,244 amino acids

### Protein family membership

- Villin/Gelsolin (IPR007122)

### Domains and repeats

1. Domain
   495 - 569
   - Gelsolin domain (IPR007123)
   612 - 684
   - Gelsolin domain (IPR007123)
   754 - 827
   - Gelsolin domain (IPR007123)
   1,047 - 1,118
   - Gelsolin domain (IPR007123)
   1,154 - 1,229
   - Gelsolin domain (IPR007123)
2. Repeat
   34 - 57
   - Leucine-rich repeat, typical subtype (IPR003591)
   78 - 100
   - Leucine-rich repeat, typical subtype (IPR003591)
   101 - 123
   - Leucine-rich repeat, typical subtype (IPR003591)
   124 - 146
   - Leucine-rich repeat, typical subtype (IPR003591)
   147 - 174
   - Leucine-rich repeat, typical subtype (IPR003591)
   196 - 219
   - Leucine-rich repeat, typical subtype (IPR003591)
   220 - 242
   - Leucine-rich repeat, typical subtype (IPR003591)
   244 - 266
   - Leucine-rich repeat, typical subtype (IPR003591)
   291 - 314
   - Leucine-rich repeat, typical subtype (IPR003591)
3. Repeat
   36 - 57
   - Leucine-rich repeat (IPR001611)
   79 - 100
   - Leucine-rich repeat (IPR001611)
   102 - 123
   - Leucine-rich repeat (IPR001611)
   126 - 148
   - Leucine-rich repeat (IPR001611)
   149 - 172
   - Leucine-rich repeat (IPR001611)
   198 - 219
   - Leucine-rich repeat (IPR001611)
   221 - 242
   - Leucine-rich repeat (IPR001611)
   245 - 267
   - Leucine-rich repeat (IPR001611)
   268 - 288
   - Leucine-rich repeat (IPR001611)
   316 - 337
   - Leucine-rich repeat (IPR001611)

1 200 400 600 800 1000 1244

### Detailed signature matches

1. IPR007122
   Villin/Gelsolin
   1. PR00597 (GELSOLIN)
      1,042 - 1,062
      PRINTS
      PR00597 (GELSOLIN)
      813 - 834
      PRINTS
      PR00597 (GELSOLIN)
      916 - 932
      PRINTS
      PR00597 (GELSOLIN)
      1,162 - 1,184
      PRINTS
      PR00597 (GELSOLIN)
   2. SM00262 (GEL)
      477 - 575
      SMART
      SM00262 (GEL)
      1,140 - 1,236
      SMART
      SM00262 (GEL)
      737 - 834
      SMART
      SM00262 (GEL)
      1,028 - 1,125
      SMART
      SM00262 (GEL)
      598 - 690
      SMART
      SM00262 (GEL)
   3. PTHR11977 (VILLIN)
      6 - 1,243
      PANTHER
      PTHR11977 (VILLIN)
2. IPR007123
   Gelsolin domain
   1. PF00626 (Gelsolin)
      1,047 - 1,118
      Pfam
      PF00626 (Gelsolin)
      1,154 - 1,229
      Pfam
      PF00626 (Gelsolin)
      612 - 684
      Pfam
      PF00626 (Gelsolin)
      495 - 569
      Pfam
      PF00626 (Gelsolin)
      754 - 827
      Pfam
      PF00626 (Gelsolin)
3. IPR003591
   Leucine-rich repeat, typical subtype
   1. SM00369 (LRR_TYP)
      147 - 174
      SMART
      SM00369 (LRR_TYP)
      196 - 219
      SMART
      SM00369 (LRR_TYP)
      220 - 242
      SMART
      SM00369 (LRR_TYP)
      291 - 314
      SMART
      SM00369 (LRR_TYP)
      124 - 146
      SMART
      SM00369 (LRR_TYP)
      244 - 266
      SMART
      SM00369 (LRR_TYP)
      101 - 123
      SMART
      SM00369 (LRR_TYP)
      78 - 100
      SMART
      SM00369 (LRR_TYP)
      34 - 57
      SMART
      SM00369 (LRR_TYP)
4. IPR001611
   Leucine-rich repeat
   1. PF00560 (LRR_1)
      149 - 170
      Pfam
      PF00560 (LRR_1)
   2. PS51450 (LRR)
      268 - 288
      PROSITE profiles
      PS51450 (LRR)
      36 - 57
      PROSITE profiles
      PS51450 (LRR)
      79 - 100
      PROSITE profiles
      PS51450 (LRR)
      316 - 337
      PROSITE profiles
      PS51450 (LRR)
      221 - 242
      PROSITE profiles
      PS51450 (LRR)
      149 - 172
      PROSITE profiles
      PS51450 (LRR)
      245 - 267
      PROSITE profiles
      PS51450 (LRR)
      102 - 123
      PROSITE profiles
      PS51450 (LRR)
      126 - 148
      PROSITE profiles
      PS51450 (LRR)
      198 - 219
      PROSITE profiles
      PS51450 (LRR)

no IPR
Unintegrated signatures

1. Coil
   882 - 903
   COILS
   Coil (Coil)
2. G3DSA:3.40.20.10
   736 - 848
   GENE3D
   G3DSA:3.40.20.10 (G3DSA:3.40.20.10)
   587 - 701
   GENE3D
   G3DSA:3.40.20.10 (G3DSA:3.40.20.10)
   1,139 - 1,240
   GENE3D
   G3DSA:3.40.20.10 (G3DSA:3.40.20.10)
   1,027 - 1,133
   GENE3D
   G3DSA:3.40.20.10 (G3DSA:3.40.20.10)
   466 - 583
   GENE3D
   G3DSA:3.40.20.10 (G3DSA:3.40.20.10)
   895 - 1,017
   GENE3D
   G3DSA:3.40.20.10 (G3DSA:3.40.20.10)
3. G3DSA:3.80.10.10
   11 - 202
   GENE3D
   G3DSA:3.80.10.10 (G3DSA:3.80.10.10)
   203 - 265
   GENE3D
   G3DSA:3.80.10.10 (G3DSA:3.80.10.10)
   266 - 347
   GENE3D
   G3DSA:3.80.10.10 (G3DSA:3.80.10.10)
4. PF13516 (LRR_6)
   56 - 70
   Pfam
   PF13516 (LRR_6)
5. PF13855 (LRR_8)
   245 - 304
   Pfam
   PF13855 (LRR_8)
   79 - 137
   Pfam
   PF13855 (LRR_8)
6. PR00019 (LEURICHRPT)
   80 - 93
   PRINTS
   PR00019 (LEURICHRPT)
   147 - 160
   PRINTS
   PR00019 (LEURICHRPT)
7. PTHR11977:SF6 (FLIG...)
   6 - 1,243
   PANTHER
   PTHR11977:SF6 (FLIGHTLESS-I)
8. SM00364 (LRR_BAC)
   243 - 262
   SMART
   SM00364 (LRR_BAC)
   100 - 119
   SMART
   SM00364 (LRR_BAC)
   219 - 238
   SMART
   SM00364 (LRR_BAC)
   196 - 215
   SMART
   SM00364 (LRR_BAC)
   77 - 96
   SMART
   SM00364 (LRR_BAC)
   314 - 333
   SMART
   SM00364 (LRR_BAC)
9. SM00365 (LRR_SD22)
   147 - 170
   SMART
   SM00365 (LRR_SD22)
   196 - 218
   SMART
   SM00365 (LRR_SD22)
   77 - 99
   SMART
   SM00365 (LRR_SD22)
   266 - 286
   SMART
   SM00365 (LRR_SD22)
10. SSF52058 (L domain-...)
    8 - 355
    SUPERFAMILY
    SSF52058 (L domain-like)
11. SSF55753 (Actin dep...)
    1,129 - 1,240
    SUPERFAMILY
    SSF55753 (Actin depolymerizing proteins)
    1,021 - 1,127
    SUPERFAMILY
    SSF55753 (Actin depolymerizing proteins)
    896 - 1,037
    SUPERFAMILY
    SSF55753 (Actin depolymerizing proteins)
    731 - 838
    SUPERFAMILY
    SSF55753 (Actin depolymerizing proteins)
    468 - 606
    SUPERFAMILY
    SSF55753 (Actin depolymerizing proteins)
    588 - 687
    SUPERFAMILY
    SSF55753 (Actin depolymerizing proteins)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0003779 actin binding
GO:0005515 protein binding

#### Cellular Component

None predicted.