Protein

## EMLSAP00000004027

Length
1,050 amino acids

### Protein family membership

- Rho GTPase activating (IPR015767)

### Domains and repeats

1. Domain
   89 - 361
   - Pyridoxal phosphate-dependent transferase (IPR015424)
     - Aromatic amino acid beta-eliminating lyase/threonine aldolase (IPR001597)
2. Domain
   90 - 136
   - Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
   137 - 240
   - Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
   363 - 397
   - WW domain (IPR001202)
   506 - 538
   - WW domain (IPR001202)
   613 - 731
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
   827 - 1,026
   - Rho GTPase activation protein (IPR008936)
     - Rho GTPase-activating protein domain (IPR000198)
3. Domain
   259 - 365
   - Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (IPR015422)

1 100 200 300 400 500 600 700 800 900 1000 1050

### Detailed signature matches

1. IPR015767
   Rho GTPase activating
   1. PTHR23181 (RHO GTPA...)
      368 - 1,028
      PANTHER
      PTHR23181 (RHO GTPASE ACTIVATING PROTEIN)
2. IPR015424
   Pyridoxal phosphate-dependent transferase
   1. SSF53383 (PLP-depen...)
      89 - 361
      SUPERFAMILY
      SSF53383 (PLP-dependent transferases)
3. IPR015421
   Pyridoxal phosphate-dependent transferase, major region, subdomain 1
   1. G3DSA:3.40.64...
      137 - 240
      GENE3D
      G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
      90 - 136
      GENE3D
      G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
4. IPR001597
   Aromatic amino acid beta-eliminating lyase/threonine aldolase
   1. PF01212 (Beta_elim_...)
      135 - 240
      Pfam
      PF01212 (Beta_elim_lyase)
5. IPR015422
   Pyridoxal phosphate-dependent transferase, major region, subdomain 2
   1. G3DSA:3.90.11...
      259 - 365
      GENE3D
      G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
6. IPR001202
   WW domain
   1. SSF51045 (WW domain)
      363 - 396
      SUPERFAMILY
      SSF51045 (WW domain)
   2. PS01159 (WW_DOMAIN_1)
      511 - 536
      PROSITE patterns
      PS01159 (WW_DOMAIN_1)
   3. PF00397 (WW)
      368 - 395
      Pfam
      PF00397 (WW)
   4. PS50020 (WW_DOMAIN_2)
      363 - 397
      PROSITE profiles
      PS50020 (WW_DOMAIN_2)
      511 - 538
      PROSITE profiles
      PS50020 (WW_DOMAIN_2)
   5. SM00456 (WW)
      506 - 538
      SMART
      SM00456 (WW)
      364 - 397
      SMART
      SM00456 (WW)
7. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      614 - 730
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
8. IPR001849
   Pleckstrin homology domain
   1. SM00233 (PH)
      614 - 731
      SMART
      SM00233 (PH)
   2. PS50003 (PH_DOMAIN)
      613 - 729
      PROSITE profiles
      PS50003 (PH_DOMAIN)
9. IPR008936
   Rho GTPase activation protein
   1. SSF48350 (GTPase ac...)
      830 - 1,025
      SUPERFAMILY
      SSF48350 (GTPase activation domain, GAP)
10. IPR000198
    Rho GTPase-activating protein domain
    1. SM00324 (RhoGAP)
       845 - 1,022
       SMART
       SM00324 (RhoGAP)
    2. G3DSA:1.10.55...
       827 - 1,026
       GENE3D
       G3DSA:1.10.555.10 (G3DSA:1.10.555.10)
    3. PF00620 (RhoGAP)
       848 - 995
       Pfam
       PF00620 (RhoGAP)
    4. PS50238 (RHOGAP)
       834 - 1,025
       PROSITE profiles
       PS50238 (RHOGAP)

no IPR
Unintegrated signatures

1. Coil
   263 - 284
   COILS
   Coil (Coil)
2. G3DSA:2.20.70.10
   511 - 538
   GENE3D
   G3DSA:2.20.70.10 (G3DSA:2.20.70.10)
   368 - 396
   GENE3D
   G3DSA:2.20.70.10 (G3DSA:2.20.70.10)
3. SSF50729 (PH domain...)
   614 - 734
   SUPERFAMILY
   SSF50729 (PH domain-like)

### GO term prediction

#### Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0007165 signal transduction

#### Molecular Function

GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding

#### Cellular Component

GO:0005622 intracellular