Protein

## EMLSAP00000007263

Length
639 amino acids

### Protein family membership

- Neurotransmitter-gated ion-channel (IPR006201)
  - Nicotinic acetylcholine receptor (IPR002394)

### Domains and repeats

1. Domain
   26 - 233
   - Neurotransmitter-gated ion-channel ligand-binding (IPR006202)
2. Domain
   233 - 408
   - Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)
   449 - 624
   - Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)
3. Domain
   233 - 338
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)
   575 - 625
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)

1 100 200 300 400 500 639

### Detailed signature matches

1. IPR006201
   Neurotransmitter-gated ion-channel
   1. PTHR18945 (NEUROTRA...)
      1 - 617
      PANTHER
      PTHR18945 (NEUROTRANSMITTER GATED ION CHANNEL)
   2. PR00252 (NRIONCHANNEL)
      151 - 165
      PRINTS
      PR00252 (NRIONCHANNEL)
      107 - 118
      PRINTS
      PR00252 (NRIONCHANNEL)
      227 - 239
      PRINTS
      PR00252 (NRIONCHANNEL)
      74 - 90
      PRINTS
      PR00252 (NRIONCHANNEL)
   3. TIGR00860
      9 - 406
      UNKNOWN
      TIGR00860 (TIGR00860)
2. IPR002394
   Nicotinic acetylcholine receptor
   1. PR00254 (NICOTINICR)
      61 - 77
      PRINTS
      PR00254 (NICOTINICR)
      95 - 109
      PRINTS
      PR00254 (NICOTINICR)
      113 - 125
      PRINTS
      PR00254 (NICOTINICR)
      131 - 149
      PRINTS
      PR00254 (NICOTINICR)
3. IPR006202
   Neurotransmitter-gated ion-channel ligand-binding
   1. PF02931 (Neur_chan_LBD)
      27 - 233
      Pfam
      PF02931 (Neur_chan_LBD)
   2. SSF63712 (Nicotinic...)
      26 - 232
      SUPERFAMILY
      SSF63712 (Nicotinic receptor ligand binding domain-like)
   3. G3DSA:2.70.17...
      28 - 232
      GENE3D
      G3DSA:2.70.170.10 (G3DSA:2.70.170.10)
4. IPR027361
   Nicotinic acetylcholine-gated receptor, transmembrane domain
   1. G3DSA:1.20.12...
      575 - 625
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
      233 - 338
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
5. IPR006029
   Neurotransmitter-gated ion-channel transmembrane domain
   1. SSF90112 (Neurotran...)
      550 - 624
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
      233 - 400
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
   2. PF02932 (Neur_chan_...)
      240 - 408
      Pfam
      PF02932 (Neur_chan_memb)
      449 - 616
      Pfam
      PF02932 (Neur_chan_memb)
6. IPR018000
   Neurotransmitter-gated ion-channel, conserved site
   1. PS00236 (NEUROTR_IO...)
      151 - 165
      PROSITE patterns
      PS00236 (NEUROTR_ION_CHANNEL)

no IPR
Unintegrated signatures

1. PTHR18945:SF72 (ACE...)
   1 - 617
   PANTHER
   PTHR18945:SF72 (ACETYLCHOLINE RECEPTOR, BETA-TYPE SUBUNIT INVERTEBRATE)
2. SignalP-noTM
   1 - 23
   SignalP euk
   SignalP-noTM (SignalP-noTM)
3. TMhelix
   332 - 349
   TMHMM
   TMhelix (TMhelix)
   234 - 256
   TMHMM
   TMhelix (TMhelix)
   271 - 293
   TMHMM
   TMhelix (TMhelix)
   602 - 624
   TMHMM
   TMhelix (TMhelix)
   300 - 322
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006810 transport
GO:0006811 ion transport

#### Molecular Function

GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005216 ion channel activity
GO:0005230 extracellular ligand-gated ion channel activity

#### Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045211 postsynaptic membrane