Protein

## EMLSAP00000004853

Length
658 amino acids

### Protein family membership

- Cation/H+ exchanger, CPA1 family (IPR018422)
  - Na+/H+ exchanger (IPR004709)
    - Na+/H+ exchanger, isoform 6 (NHE6) (IPR002090)

### Domains and repeats

1. Domain
   148 - 511
   - Cation/H+ exchanger (IPR006153)

1 100 200 300 400 500 600 658

### Detailed signature matches

1. IPR018422
   Cation/H+ exchanger, CPA1 family
   1. PTHR10110 (SODIUM/H...)
      1 - 601
      PANTHER
      PTHR10110 (SODIUM/HYDROGEN EXCHANGER)
2. IPR004709
   Na+/H+ exchanger
   1. PR01084 (NAHEXCHNGR)
      161 - 172
      PRINTS
      PR01084 (NAHEXCHNGR)
      175 - 189
      PRINTS
      PR01084 (NAHEXCHNGR)
      231 - 241
      PRINTS
      PR01084 (NAHEXCHNGR)
      190 - 198
      PRINTS
      PR01084 (NAHEXCHNGR)
   2. TIGR00840
      148 - 577
      UNKNOWN
      TIGR00840 (TIGR00840)
3. IPR002090
   Na+/H+ exchanger, isoform 6 (NHE6)
   1. PR01088 (NAHEXCHNGR6)
      46 - 64
      PRINTS
      PR01088 (NAHEXCHNGR6)
      21 - 45
      PRINTS
      PR01088 (NAHEXCHNGR6)
      65 - 91
      PRINTS
      PR01088 (NAHEXCHNGR6)
4. IPR006153
   Cation/H+ exchanger
   1. PF00999 (Na_H_Excha...)
      148 - 511
      Pfam
      PF00999 (Na_H_Exchanger)

no IPR
Unintegrated signatures

1. PTHR10110:SF60 (SOD...)
   1 - 601
   PANTHER
   PTHR10110:SF60 (SODIUM/HYDROGEN EXCHANGER 6)
2. TMhelix
   190 - 212
   TMHMM
   TMhelix (TMhelix)
   391 - 413
   TMHMM
   TMhelix (TMhelix)
   493 - 515
   TMHMM
   TMhelix (TMhelix)
   55 - 77
   TMHMM
   TMhelix (TMhelix)
   227 - 246
   TMHMM
   TMhelix (TMhelix)
   423 - 445
   TMHMM
   TMhelix (TMhelix)
   161 - 178
   TMHMM
   TMhelix (TMhelix)
   304 - 326
   TMHMM
   TMhelix (TMhelix)
   29 - 48
   TMHMM
   TMhelix (TMhelix)
   348 - 370
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0055085 transmembrane transport

#### Molecular Function

GO:0015299 solute:hydrogen antiporter activity
GO:0015385 sodium:hydrogen antiporter activity

#### Cellular Component

GO:0016021 integral component of membrane