Protein

## EMLSAP00000005921

Length
3,605 amino acids

### Protein family membership

- Dynein heavy chain (IPR026983)

### Domains and repeats

1. Domain
   385 - 784
   - Dynein heavy chain, domain-2 (IPR013602)
   945 - 1,145
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
     - AAA+ ATPase domain (IPR003593)
   1,188 - 1,425
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
     - AAA+ ATPase domain (IPR003593)
   1,625 - 1,815
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
     - AAA+ ATPase domain (IPR003593)
   1,870 - 2,168
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
     - AAA+ ATPase domain (IPR003593)
   2,171 - 2,489
   - Dynein heavy chain, coiled coil stalk (IPR024743)
   2,877 - 3,600
   - Dynein heavy chain domain (IPR004273)
2. Domain
   1,263 - 1,392
   - ATPase, dynein-related, AAA domain (IPR011704)
   1,876 - 2,154
   - Dynein heavy chain, P-loop containing D4 domain (IPR024317)

1 500 1000 1500 2000 2500 3000 3605

### Detailed signature matches

1. IPR026983
   Dynein heavy chain
   1. PTHR10676 (DYNEIN H...)
      10 - 3,604
      PANTHER
      PTHR10676 (DYNEIN HEAVY CHAIN FAMILY PROTEIN)
2. IPR013602
   Dynein heavy chain, domain-2
   1. PF08393 (DHC_N2)
      385 - 784
      Pfam
      PF08393 (DHC_N2)
3. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      1,188 - 1,425
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      949 - 1,145
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      1,625 - 1,815
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      1,870 - 1,993
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      2,025 - 2,168
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
4. IPR003593
   AAA+ ATPase domain
   1. SM00382 (AAA)
      1,634 - 1,782
      SMART
      SM00382 (AAA)
      1,898 - 2,064
      SMART
      SM00382 (AAA)
      945 - 1,086
      SMART
      SM00382 (AAA)
      1,259 - 1,410
      SMART
      SM00382 (AAA)
5. IPR011704
   ATPase, dynein-related, AAA domain
   1. PF07728 (AAA_5)
      1,263 - 1,392
      Pfam
      PF07728 (AAA_5)
6. IPR024317
   Dynein heavy chain, P-loop containing D4 domain
   1. PF12780 (AAA_8)
      1,876 - 2,154
      Pfam
      PF12780 (AAA_8)
7. IPR024743
   Dynein heavy chain, coiled coil stalk
   1. PF12777 (MT)
      2,171 - 2,489
      Pfam
      PF12777 (MT)
8. IPR004273
   Dynein heavy chain domain
   1. PF03028 (Dynein_heavy)
      2,877 - 3,600
      Pfam
      PF03028 (Dynein_heavy)

no IPR
Unintegrated signatures

1. Coil
   348 - 372
   COILS
   Coil (Coil)
   2,730 - 2,751
   COILS
   Coil (Coil)
   2,196 - 2,231
   COILS
   Coil (Coil)
   2,390 - 2,432
   COILS
   Coil (Coil)
   524 - 545
   COILS
   Coil (Coil)
   658 - 683
   COILS
   Coil (Coil)
2. G3DSA:3.40.50...
   948 - 1,074
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   1,189 - 1,425
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   2,025 - 2,081
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   1,870 - 1,993
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   1,611 - 1,755
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
3. PF12774 (AAA_6)
   922 - 1,146
   Pfam
   PF12774 (AAA_6)
4. PF12775 (AAA_7)
   1,614 - 1,754
   Pfam
   PF12775 (AAA_7)
5. PF12781 (AAA_9)
   2,517 - 2,741
   Pfam
   PF12781 (AAA_9)
6. PTHR10676:SF28 (CYT...)
   10 - 3,604
   PANTHER
   PTHR10676:SF28 (CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1)

### GO term prediction

#### Biological Process

GO:0007018 microtubule-based movement

#### Molecular Function

GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity

#### Cellular Component

GO:0030286 dynein complex