Protein

## EMLSAP00000010449

Length
362 amino acids

### Protein family membership

- Disintegrin and metalloproteinase domain-containing protein 10 (IPR027053)

### Domains and repeats

1. Domain
   20 - 241
   - Metallopeptidase, catalytic domain (IPR024079)
2. Domain
   22 - 231
   - Peptidase M12B, ADAM/reprolysin (IPR001590)

1 50 100 150 200 250 300 362

### Detailed signature matches

1. IPR027053
   Disintegrin and metalloproteinase domain-containing protein 10
   1. PTHR11905:SF4 (ADAM 10)
      19 - 301
      PANTHER
      PTHR11905:SF4 (ADAM 10)
2. IPR024079
   Metallopeptidase, catalytic domain
   1. G3DSA:3.40.39...
      20 - 241
      GENE3D
      G3DSA:3.40.390.10 (G3DSA:3.40.390.10)
3. IPR001590
   Peptidase M12B, ADAM/reprolysin
   1. PS50215 (ADAM_MEPRO)
      22 - 231
      PROSITE profiles
      PS50215 (ADAM_MEPRO)

no IPR
Unintegrated signatures

1. PF13688 (Reprolysin_5)
   21 - 200
   Pfam
   PF13688 (Reprolysin_5)
2. PTHR11905 (ADAM (A ...)
   19 - 301
   PANTHER
   PTHR11905 (ADAM (A DISINTEGRIN AND METALLOPROTEASE DOMAIN))
3. SSF55486 (Metallopr...)
   20 - 230
   SUPERFAMILY
   SSF55486 (Metalloproteases ("zincins"), catalytic domain)
4. SignalP-noTM
   1 - 18
   SignalP euk
   SignalP-noTM (SignalP-noTM)
5. TMhelix
   314 - 336
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007219 Notch signaling pathway

#### Molecular Function

GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity

#### Cellular Component

None predicted.