Protein

## EMLSAP00000001195

Length
753 amino acids

### Protein family membership

- DNA mismatch repair protein family (IPR002099)
  - DNA mismatch repair protein Pms1/Mlh2 (IPR015434)

### Domains and repeats

1. Domain
   6 - 146
   - Histidine kinase-like ATPase, ATP-binding domain (IPR003594)
2. Domain
   134 - 271
   - Ribosomal protein S5 domain 2-type fold (IPR020568)
     - Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721)
       - DNA mismatch repair protein, C-terminal (IPR013507)
   567 - 715
   - MutL, C-terminal, dimerisation (IPR014790)

1 100 200 300 400 500 600 700 753

### Detailed signature matches

1. IPR002099
   DNA mismatch repair protein family
   1. PTHR10073 (DNA MISM...)
      6 - 753
      PANTHER
      PTHR10073 (DNA MISMATCH REPAIR PROTEIN (MLH, PMS, MUTL))
2. IPR015434
   DNA mismatch repair protein Pms1/Mlh2
   1. PTHR10073:SF9 (DNA ...)
      6 - 753
      PANTHER
      PTHR10073:SF9 (DNA MISMATCH REPAIR PROTEIN PMS1)
3. IPR003594
   Histidine kinase-like ATPase, ATP-binding domain
   1. SSF55874 (ATPase do...)
      6 - 137
      SUPERFAMILY
      SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
   2. G3DSA:3.30.56...
      6 - 146
      GENE3D
      G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
4. IPR020568
   Ribosomal protein S5 domain 2-type fold
   1. SSF54211 (Ribosomal...)
      134 - 271
      SUPERFAMILY
      SSF54211 (Ribosomal protein S5 domain 2-like)
5. IPR014721
   Ribosomal protein S5 domain 2-type fold, subgroup
   1. G3DSA:3.30.23...
      147 - 270
      GENE3D
      G3DSA:3.30.230.10 (G3DSA:3.30.230.10)
6. IPR013507
   DNA mismatch repair protein, C-terminal
   1. PF01119 (DNA_mis_re...)
      153 - 270
      Pfam
      PF01119 (DNA_mis_repair)
7. IPR014790
   MutL, C-terminal, dimerisation
   1. PF08676 (MutL_C)
      567 - 715
      Pfam
      PF08676 (MutL_C)
   2. SM00853 (MutL_C)
      568 - 715
      SMART
      SM00853 (MutL_C)
8. IPR014762
   DNA mismatch repair, conserved site
   1. PS00058 (DNA_MISMAT...)
      31 - 37
      PROSITE patterns
      PS00058 (DNA_MISMATCH_REPAIR_1)

no IPR
Unintegrated signatures

1. SSF118116 (DNA mism...)
   564 - 746
   SUPERFAMILY
   SSF118116 (DNA mismatch repair protein MutL)

### GO term prediction

#### Biological Process

GO:0006298 mismatch repair

#### Molecular Function

GO:0005524 ATP binding
GO:0030983 mismatched DNA binding

#### Cellular Component

GO:0032389 MutLalpha complex