Protein

## EMLSAP00000006889

Length
5,826 amino acids

### Protein family membership

- Sodium/potassium-transporting P-type ATPase, subfamily IIC (IPR005775)

- Cation-transporting P-type ATPase (IPR001757)

### Domains and repeats

1. Domain
   18 - 92
   - Cation-transporting P-type ATPase, N-terminal (IPR004014)
   567 - 601
   - P-type ATPase, transmembrane domain (IPR023298)
   644 - 995
   - P-type ATPase, transmembrane domain (IPR023298)
   1,004 - 1,078
   - Cation-transporting P-type ATPase, N-terminal (IPR004014)
   1,552 - 1,586
   - P-type ATPase, transmembrane domain (IPR023298)
   1,629 - 1,865
   - P-type ATPase, transmembrane domain (IPR023298)
   1,880 - 1,954
   - Cation-transporting P-type ATPase, N-terminal (IPR004014)
   2,428 - 2,462
   - P-type ATPase, transmembrane domain (IPR023298)
   2,505 - 2,857
   - P-type ATPase, transmembrane domain (IPR023298)
   2,903 - 2,938
   - Myosin, N-terminal, SH3-like (IPR004009)
   2,949 - 3,654
   - Myosin head, motor domain (IPR001609)
   4,844 - 4,918
   - Cation-transporting P-type ATPase, N-terminal (IPR004014)
   5,392 - 5,426
   - P-type ATPase, transmembrane domain (IPR023298)
   5,469 - 5,817
   - P-type ATPase, transmembrane domain (IPR023298)
2. Domain
   28 - 72
   - P-type ATPase, A domain (IPR008250)
   111 - 342
   - P-type ATPase, A domain (IPR008250)
   1,015 - 1,058
   - P-type ATPase, A domain (IPR008250)
   1,097 - 1,328
   - P-type ATPase, A domain (IPR008250)
   1,891 - 1,934
   - P-type ATPase, A domain (IPR008250)
   1,973 - 2,204
   - P-type ATPase, A domain (IPR008250)
   3,652 - 3,715
   - Myosin-like IQ motif-containing domain (IPR027401)
   4,854 - 4,898
   - P-type ATPase, A domain (IPR008250)
   4,937 - 5,168
   - P-type ATPase, A domain (IPR008250)
3. Domain
   338 - 736
   - HAD-like domain (IPR023214)
     - P-type ATPase, cytoplasmic domain N (IPR023299)
   776 - 982
   - Cation-transporting P-type ATPase, C-terminal (IPR006068)
   1,324 - 1,721
   - HAD-like domain (IPR023214)
     - P-type ATPase, cytoplasmic domain N (IPR023299)
   1,761 - 1,928
   - Cation-transporting P-type ATPase, C-terminal (IPR006068)
   2,200 - 2,597
   - HAD-like domain (IPR023214)
     - P-type ATPase, cytoplasmic domain N (IPR023299)
   2,637 - 2,846
   - Cation-transporting P-type ATPase, C-terminal (IPR006068)
   2,926 - 3,708
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   3,944 - 4,796
   - Myosin tail (IPR002928)
   5,164 - 5,561
   - HAD-like domain (IPR023214)
     - P-type ATPase, cytoplasmic domain N (IPR023299)
   5,601 - 5,810
   - Cation-transporting P-type ATPase, C-terminal (IPR006068)

1 1000 2000 3000 4000 5000 5826

### Detailed signature matches

1. IPR005775
   Sodium/potassium-transporting P-type ATPase, subfamily IIC
   1. TIGR01106
      990 - 1,866
      UNKNOWN
      TIGR01106 (TIGR01106)
      4,833 - 5,826
      UNKNOWN
      TIGR01106 (TIGR01106)
      1,868 - 2,858
      UNKNOWN
      TIGR01106 (TIGR01106)
      4 - 982
      UNKNOWN
      TIGR01106 (TIGR01106)
2. IPR001757
   Cation-transporting P-type ATPase
   1. TIGR01494
      4,938 - 5,206
      UNKNOWN
      TIGR01494 (TIGR01494)
      1,974 - 2,242
      UNKNOWN
      TIGR01494 (TIGR01494)
      1,098 - 1,363
      UNKNOWN
      TIGR01494 (TIGR01494)
      1,651 - 1,767
      UNKNOWN
      TIGR01494 (TIGR01494)
      2,527 - 2,644
      UNKNOWN
      TIGR01494 (TIGR01494)
      112 - 380
      UNKNOWN
      TIGR01494 (TIGR01494)
      5,491 - 5,608
      UNKNOWN
      TIGR01494 (TIGR01494)
      666 - 782
      UNKNOWN
      TIGR01494 (TIGR01494)
   2. PR00119 (CATATPASE)
      2,212 - 2,226
      PRINTS
      PR00119 (CATATPASE)
      2,447 - 2,457
      PRINTS
      PR00119 (CATATPASE)
      2,577 - 2,589
      PRINTS
      PR00119 (CATATPASE)
      2,052 - 2,066
      PRINTS
      PR00119 (CATATPASE)
      2,425 - 2,436
      PRINTS
      PR00119 (CATATPASE)
      2,553 - 2,572
      PRINTS
      PR00119 (CATATPASE)
3. IPR004014
   Cation-transporting P-type ATPase, N-terminal
   1. PF00690 (Cation_ATP...)
      1,006 - 1,073
      Pfam
      PF00690 (Cation_ATPase_N)
      20 - 87
      Pfam
      PF00690 (Cation_ATPase_N)
      1,882 - 1,949
      Pfam
      PF00690 (Cation_ATPase_N)
      4,846 - 4,912
      Pfam
      PF00690 (Cation_ATPase_N)
   2. SM00831 (Cation_ATP...)
      1,880 - 1,954
      SMART
      SM00831 (Cation_ATPase_N)
      18 - 92
      SMART
      SM00831 (Cation_ATPase_N)
      4,844 - 4,918
      SMART
      SM00831 (Cation_ATPase_N)
      1,004 - 1,078
      SMART
      SM00831 (Cation_ATPase_N)
4. IPR008250
   P-type ATPase, A domain
   1. G3DSA:2.70.15...
      1,015 - 1,058
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
      4,969 - 5,074
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
      28 - 72
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
      1,891 - 1,934
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
      1,129 - 1,234
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
      4,854 - 4,898
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
      2,005 - 2,110
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
      143 - 248
      GENE3D
      G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
   2. PF00122 (E1-E2_ATPase)
      1,973 - 2,204
      Pfam
      PF00122 (E1-E2_ATPase)
      4,937 - 5,168
      Pfam
      PF00122 (E1-E2_ATPase)
      1,097 - 1,328
      Pfam
      PF00122 (E1-E2_ATPase)
      111 - 342
      Pfam
      PF00122 (E1-E2_ATPase)
5. IPR023214
   HAD-like domain
   1. PF00702 (Hydrolase)
      2,209 - 2,567
      Pfam
      PF00702 (Hydrolase)
      1,333 - 1,691
      Pfam
      PF00702 (Hydrolase)
      5,173 - 5,531
      Pfam
      PF00702 (Hydrolase)
      347 - 706
      Pfam
      PF00702 (Hydrolase)
   2. SSF56784 (HAD-like)
      1,642 - 1,721
      SUPERFAMILY
      SSF56784 (HAD-like)
      1,324 - 1,397
      SUPERFAMILY
      SSF56784 (HAD-like)
      1,547 - 1,614
      SUPERFAMILY
      SSF56784 (HAD-like)
      562 - 620
      SUPERFAMILY
      SSF56784 (HAD-like)
      338 - 362
      SUPERFAMILY
      SSF56784 (HAD-like)
      491 - 518
      SUPERFAMILY
      SSF56784 (HAD-like)
      667 - 736
      SUPERFAMILY
      SSF56784 (HAD-like)
      5,482 - 5,561
      SUPERFAMILY
      SSF56784 (HAD-like)
      5,323 - 5,449
      SUPERFAMILY
      SSF56784 (HAD-like)
      5,164 - 5,188
      SUPERFAMILY
      SSF56784 (HAD-like)
      2,518 - 2,597
      SUPERFAMILY
      SSF56784 (HAD-like)
      2,200 - 2,273
      SUPERFAMILY
      SSF56784 (HAD-like)
      2,423 - 2,480
      SUPERFAMILY
      SSF56784 (HAD-like)
6. IPR023299
   P-type ATPase, cytoplasmic domain N
   1. SSF81660 (Metal cat...)
      2,221 - 2,433
      SUPERFAMILY
      SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
      5,185 - 5,397
      SUPERFAMILY
      SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
      359 - 572
      SUPERFAMILY
      SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
      1,345 - 1,557
      SUPERFAMILY
      SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
   2. G3DSA:3.40.11...
      2,203 - 2,427
      GENE3D
      G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
      1,327 - 1,551
      GENE3D
      G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
      341 - 566
      GENE3D
      G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
      5,167 - 5,391
      GENE3D
      G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
7. IPR023298
   P-type ATPase, transmembrane domain
   1. G3DSA:1.20.11...
      2,428 - 2,462
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
      567 - 601
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
      1,552 - 1,586
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
      5,469 - 5,817
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
      644 - 995
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
      5,392 - 5,426
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
      1,629 - 1,865
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
      2,505 - 2,857
      GENE3D
      G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
8. IPR006068
   Cation-transporting P-type ATPase, C-terminal
   1. PF00689 (Cation_ATP...)
      2,637 - 2,846
      Pfam
      PF00689 (Cation_ATPase_C)
      5,601 - 5,810
      Pfam
      PF00689 (Cation_ATPase_C)
      1,761 - 1,928
      Pfam
      PF00689 (Cation_ATPase_C)
      776 - 982
      Pfam
      PF00689 (Cation_ATPase_C)
9. IPR004009
   Myosin, N-terminal, SH3-like
   1. PF02736 (Myosin_N)
      2,903 - 2,938
      Pfam
      PF02736 (Myosin_N)
10. IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
       2,926 - 3,708
       SUPERFAMILY
       SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
11. IPR001609
    Myosin head, motor domain
    1. PF00063 (Myosin_head)
       2,958 - 3,641
       Pfam
       PF00063 (Myosin_head)
    2. SM00242 (MYSc)
       2,949 - 3,654
       SMART
       SM00242 (MYSc)
12. IPR027401
    Myosin-like IQ motif-containing domain
    1. G3DSA:4.10.27...
       3,652 - 3,715
       GENE3D
       G3DSA:4.10.270.10 (G3DSA:4.10.270.10)
13. IPR002928
    Myosin tail
    1. PF01576 (Myosin_tail_1)
       3,944 - 4,796
       Pfam
       PF01576 (Myosin_tail_1)
14. IPR018303
    P-type ATPase, phosphorylation site
    1. PS00154 (ATPASE_E1_E2)
       352 - 358
       PROSITE patterns
       PS00154 (ATPASE_E1_E2)
       1,338 - 1,344
       PROSITE patterns
       PS00154 (ATPASE_E1_E2)
       2,214 - 2,220
       PROSITE patterns
       PS00154 (ATPASE_E1_E2)
       5,178 - 5,184
       PROSITE patterns
       PS00154 (ATPASE_E1_E2)
15. IPR000048
    IQ motif, EF-hand binding site
    1. PS50096 (IQ)
       3,657 - 3,685
       PROSITE profiles
       PS50096 (IQ)

no IPR
Unintegrated signatures

1. Coil
   4,359 - 4,391
   COILS
   Coil (Coil)
   3,941 - 4,036
   COILS
   Coil (Coil)
   4,068 - 4,124
   COILS
   Coil (Coil)
   4,595 - 4,637
   COILS
   Coil (Coil)
   4,328 - 4,349
   COILS
   Coil (Coil)
   4,476 - 4,518
   COILS
   Coil (Coil)
   4,258 - 4,300
   COILS
   Coil (Coil)
   4,736 - 4,774
   COILS
   Coil (Coil)
   4,398 - 4,465
   COILS
   Coil (Coil)
   4,138 - 4,159
   COILS
   Coil (Coil)
   3,815 - 3,899
   COILS
   Coil (Coil)
   4,775 - 4,799
   COILS
   Coil (Coil)
   4,039 - 4,060
   COILS
   Coil (Coil)
   3,724 - 3,759
   COILS
   Coil (Coil)
   991 - 1,012
   COILS
   Coil (Coil)
   4,525 - 4,553
   COILS
   Coil (Coil)
   4,194 - 4,215
   COILS
   Coil (Coil)
2. G3DSA:4.10.6.10
   1,972 - 2,004
   GENE3D
   G3DSA:4.10.6.10 (G3DSA:4.10.6.10)
   1,096 - 1,128
   GENE3D
   G3DSA:4.10.6.10 (G3DSA:4.10.6.10)
   4,936 - 4,968
   GENE3D
   G3DSA:4.10.6.10 (G3DSA:4.10.6.10)
   110 - 142
   GENE3D
   G3DSA:4.10.6.10 (G3DSA:4.10.6.10)
3. PR00121 (NAKATPASE)
   79 - 93
   PRINTS
   PR00121 (NAKATPASE)
   482 - 500
   PRINTS
   PR00121 (NAKATPASE)
   893 - 913
   PRINTS
   PR00121 (NAKATPASE)
   343 - 364
   PRINTS
   PR00121 (NAKATPASE)
   927 - 951
   PRINTS
   PR00121 (NAKATPASE)
   270 - 292
   PRINTS
   PR00121 (NAKATPASE)
   764 - 785
   PRINTS
   PR00121 (NAKATPASE)
   106 - 126
   PRINTS
   PR00121 (NAKATPASE)
   831 - 851
   PRINTS
   PR00121 (NAKATPASE)
4. PTHR13140 (MYOSIN)
   2,904 - 4,805
   PANTHER
   PTHR13140 (MYOSIN)
5. PTHR13140:SF23 (MYO...)
   2,904 - 4,805
   PANTHER
   PTHR13140:SF23 (MYOSIN HEAVY CHAIN, NONMUSCLE OR SMOOTH MUSCLE)
6. SSF81653 (Calcium A...)
   142 - 248
   SUPERFAMILY
   SSF81653 (Calcium ATPase, transduction domain A)
   1,128 - 1,234
   SUPERFAMILY
   SSF81653 (Calcium ATPase, transduction domain A)
   4,968 - 5,074
   SUPERFAMILY
   SSF81653 (Calcium ATPase, transduction domain A)
   2,004 - 2,110
   SUPERFAMILY
   SSF81653 (Calcium ATPase, transduction domain A)
7. SSF81665 (Calcium A...)
   1,003 - 1,129
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   1,237 - 1,330
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   1,727 - 1,866
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   1,881 - 2,005
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   2,113 - 2,206
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   2,603 - 2,852
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   5,077 - 5,170
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   5,567 - 5,816
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   4,843 - 4,969
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   742 - 982
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   17 - 143
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
   251 - 344
   SUPERFAMILY
   SSF81665 (Calcium ATPase, transmembrane domain M)
8. SSF90257 (Myosin ro...)
   4,108 - 4,225
   SUPERFAMILY
   SSF90257 (Myosin rod fragments)
   3,938 - 4,028
   SUPERFAMILY
   SSF90257 (Myosin rod fragments)
   4,504 - 4,618
   SUPERFAMILY
   SSF90257 (Myosin rod fragments)
   3,836 - 3,945
   SUPERFAMILY
   SSF90257 (Myosin rod fragments)
   4,308 - 4,426
   SUPERFAMILY
   SSF90257 (Myosin rod fragments)
9. TMhelix
   2,823 - 2,840
   TMHMM
   TMhelix (TMhelix)
   962 - 984
   TMHMM
   TMhelix (TMhelix)
   298 - 320
   TMHMM
   TMhelix (TMhelix)
   829 - 851
   TMHMM
   TMhelix (TMhelix)
   890 - 909
   TMHMM
   TMhelix (TMhelix)
   1,812 - 1,834
   TMHMM
   TMhelix (TMhelix)
   106 - 125
   TMHMM
   TMhelix (TMhelix)
   2,695 - 2,717
   TMHMM
   TMhelix (TMhelix)
   1,092 - 1,111
   TMHMM
   TMhelix (TMhelix)
   4,897 - 4,919
   TMHMM
   TMhelix (TMhelix)
   1,252 - 1,274
   TMHMM
   TMhelix (TMhelix)
   930 - 947
   TMHMM
   TMhelix (TMhelix)
   2,626 - 2,648
   TMHMM
   TMhelix (TMhelix)
   4,932 - 4,951
   TMHMM
   TMhelix (TMhelix)
   5,754 - 5,776
   TMHMM
   TMhelix (TMhelix)
   2,128 - 2,150
   TMHMM
   TMhelix (TMhelix)
   2,160 - 2,182
   TMHMM
   TMhelix (TMhelix)
   5,093 - 5,115
   TMHMM
   TMhelix (TMhelix)
   2,983 - 3,005
   TMHMM
   TMhelix (TMhelix)
   1,933 - 1,955
   TMHMM
   TMhelix (TMhelix)
   5,786 - 5,803
   TMHMM
   TMhelix (TMhelix)
   5,122 - 5,144
   TMHMM
   TMhelix (TMhelix)
   5,659 - 5,681
   TMHMM
   TMhelix (TMhelix)
   2,786 - 2,808
   TMHMM
   TMhelix (TMhelix)
   1,284 - 1,306
   TMHMM
   TMhelix (TMhelix)
   1,057 - 1,079
   TMHMM
   TMhelix (TMhelix)
   1,750 - 1,772
   TMHMM
   TMhelix (TMhelix)
   1,968 - 1,987
   TMHMM
   TMhelix (TMhelix)
   71 - 93
   TMHMM
   TMhelix (TMhelix)
   266 - 288
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006754 ATP biosynthetic process
GO:0006812 cation transport
GO:0015672 monovalent inorganic cation transport

#### Molecular Function

GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding

#### Cellular Component

GO:0016021 integral component of membrane
GO:0016459 myosin complex