Protein

## EMLSAP00000009967

Length
678 amino acids

### Protein family membership

- Peptidase C2, calpain family (IPR022684)

### Domains and repeats

1. Domain
   4 - 372
   - Peptidase C2, calpain, catalytic domain (IPR001300)
   374 - 533
   - Peptidase C2, calpain, large subunit, domain III (IPR022682)
     - Peptidase C2, calpain, domain III (IPR022683)
   549 - 649
   - C2 domain (IPR000008)

1 100 200 300 400 500 600 678

### Detailed signature matches

1. IPR022684
   Peptidase C2, calpain family
   1. PR00704 (CALPAIN)
      73 - 89
      PRINTS
      PR00704 (CALPAIN)
      7 - 30
      PRINTS
      PR00704 (CALPAIN)
      340 - 361
      PRINTS
      PR00704 (CALPAIN)
      168 - 195
      PRINTS
      PR00704 (CALPAIN)
      497 - 525
      PRINTS
      PR00704 (CALPAIN)
      143 - 166
      PRINTS
      PR00704 (CALPAIN)
      113 - 138
      PRINTS
      PR00704 (CALPAIN)
      49 - 71
      PRINTS
      PR00704 (CALPAIN)
      389 - 406
      PRINTS
      PR00704 (CALPAIN)
2. IPR001300
   Peptidase C2, calpain, catalytic domain
   1. PS50203 (CALPAIN_CAT)
      22 - 364
      PROSITE profiles
      PS50203 (CALPAIN_CAT)
   2. SM00230 (CysPc)
      4 - 372
      SMART
      SM00230 (CysPc)
   3. PF00648 (Peptidase_C2)
      23 - 299
      Pfam
      PF00648 (Peptidase_C2)
      321 - 363
      Pfam
      PF00648 (Peptidase_C2)
3. IPR022682
   Peptidase C2, calpain, large subunit, domain III
   1. SSF49758 (Calpain l...)
      375 - 533
      SUPERFAMILY
      SSF49758 (Calpain large subunit, middle domain (domain III))
   2. PF01067 (Calpain_III)
      374 - 527
      Pfam
      PF01067 (Calpain_III)
4. IPR022683
   Peptidase C2, calpain, domain III
   1. SM00720 (calpain_III)
      374 - 531
      SMART
      SM00720 (calpain_III)
5. IPR000008
   C2 domain
   1. PF00168 (C2)
      555 - 634
      Pfam
      PF00168 (C2)
   2. PS50004 (C2)
      555 - 635
      PROSITE profiles
      PS50004 (C2)
   3. SSF49562 (C2 domain...)
      549 - 649
      SUPERFAMILY
      SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
   4. SM00239 (C2)
      553 - 648
      SMART
      SM00239 (C2)
6. IPR000169
   Cysteine peptidase, cysteine active site
   1. PS00139 (THIOL_PROT...)
      73 - 84
      PROSITE patterns
      PS00139 (THIOL_PROTEASE_CYS)

no IPR
Unintegrated signatures

1. G3DSA:2.60.12...
   374 - 525
   GENE3D
   G3DSA:2.60.120.380 (G3DSA:2.60.120.380)
2. G3DSA:2.60.40...
   547 - 665
   GENE3D
   G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
3. G3DSA:3.90.70.10
   343 - 370
   GENE3D
   G3DSA:3.90.70.10 (G3DSA:3.90.70.10)
   204 - 286
   GENE3D
   G3DSA:3.90.70.10 (G3DSA:3.90.70.10)
4. PTHR10183 (CALPAIN)
   1 - 676
   PANTHER
   PTHR10183 (CALPAIN)
5. PTHR10183:SF33 (CAL...)
   1 - 676
   PANTHER
   PTHR10183:SF33 (CALPAIN-5)
6. SSF54001 (Cysteine ...)
   4 - 366
   SUPERFAMILY
   SSF54001 (Cysteine proteinases)

### GO term prediction

#### Biological Process

GO:0006508 proteolysis

#### Molecular Function

GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005515 protein binding

#### Cellular Component

GO:0005622 intracellular