Protein

## EMLSAP00000005531

Length
499 amino acids

### Protein family membership

- DNA topoisomerase, type IA (IPR000380)

### Domains and repeats

1. Domain
   1 - 187
   - DNA topoisomerase, type IA, DNA-binding (IPR003602)
2. Domain
   6 - 225
   - DNA topoisomerase, type IA, central (IPR013497)
3. Domain
   7 - 275
   - DNA topoisomerase, type IA, core domain (IPR023405)
4. Domain
   20 - 125
   - DNA topoisomerase, type IA, central region, subdomain 2 (IPR013825)
   126 - 238
   - DNA topoisomerase, type IA, central region, subdomain 1 (IPR013824)

1 50 100 150 200 250 300 350 400 450 499

### Detailed signature matches

1. IPR000380
   DNA topoisomerase, type IA
   1. PTHR11390 (PROKARYO...)
      4 - 487
      PANTHER
      PTHR11390 (PROKARYOTIC DNA TOPOISOMERASE)
2. IPR003602
   DNA topoisomerase, type IA, DNA-binding
   1. SM00437 (TOP1Ac)
      1 - 187
      SMART
      SM00437 (TOP1Ac)
3. IPR013497
   DNA topoisomerase, type IA, central
   1. PF01131 (Topoisom_bac)
      6 - 225
      Pfam
      PF01131 (Topoisom_bac)
4. IPR023405
   DNA topoisomerase, type IA, core domain
   1. SSF56712 (Prokaryot...)
      7 - 275
      SUPERFAMILY
      SSF56712 (Prokaryotic type I DNA topoisomerase)
5. IPR013825
   DNA topoisomerase, type IA, central region, subdomain 2
   1. G3DSA:2.70.20.10
      20 - 125
      GENE3D
      G3DSA:2.70.20.10 (G3DSA:2.70.20.10)
6. IPR013824
   DNA topoisomerase, type IA, central region, subdomain 1
   1. G3DSA:1.10.46...
      126 - 238
      GENE3D
      G3DSA:1.10.460.10 (G3DSA:1.10.460.10)

no IPR
Unintegrated signatures

1. G3DSA:3.90.10.10
   411 - 417
   GENE3D
   G3DSA:3.90.10.10 (G3DSA:3.90.10.10)
   264 - 378
   GENE3D
   G3DSA:3.90.10.10 (G3DSA:3.90.10.10)
2. SSF48695 (Multiheme...)
   327 - 372
   SUPERFAMILY
   SSF48695 (Multiheme cytochromes)
   414 - 450
   SUPERFAMILY
   SSF48695 (Multiheme cytochromes)

### GO term prediction

#### Biological Process

GO:0006265 DNA topological change

#### Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity

#### Cellular Component

None predicted.