Protein

## EMLSAP00000000123

Length
679 amino acids

### Protein family membership

- Protein vav (IPR028530)

### Domains and repeats

1. Domain
   20 - 166
   - Calponin homology domain (IPR001715)
   232 - 419
   - Dbl homology (DH) domain (IPR000219)
   527 - 575
   - Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219)
   646 - 678
   - SH2 domain (IPR000980)
2. Domain
   410 - 531
   - Pleckstrin homology-like domain (IPR011993)

1 100 200 300 400 500 600 679

### Detailed signature matches

1. IPR028530
   Protein vav
   1. PTHR22826:SF53 (VAV...)
      1 - 678
      PANTHER
      PTHR22826:SF53 (VAV PROTEIN)
2. IPR001715
   Calponin homology domain
   1. PF00307 (CH)
      52 - 151
      Pfam
      PF00307 (CH)
   2. G3DSA:1.10.41...
      22 - 153
      GENE3D
      G3DSA:1.10.418.10 (G3DSA:1.10.418.10)
   3. SSF47576 (Calponin-...)
      20 - 166
      SUPERFAMILY
      SSF47576 (Calponin-homology domain, CH-domain)
   4. SM00033 (CH)
      26 - 148
      SMART
      SM00033 (CH)
   5. PS50021 (CH)
      24 - 152
      PROSITE profiles
      PS50021 (CH)
3. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      244 - 410
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      232 - 385
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      245 - 384
      Pfam
      PF00621 (RhoGEF)
   4. PS50010 (DH_2)
      240 - 419
      PROSITE profiles
      PS50010 (DH_2)
   5. G3DSA:1.20.90...
      236 - 385
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
4. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      410 - 531
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
5. IPR002219
   Protein kinase C-like, phorbol ester/diacylglycerol binding
   1. PS50081 (ZF_DAG_PE_2)
      527 - 575
      PROSITE profiles
      PS50081 (ZF_DAG_PE_2)
   2. PF00130 (C1_1)
      528 - 571
      Pfam
      PF00130 (C1_1)
   3. PS00479 (ZF_DAG_PE_1)
      528 - 575
      PROSITE patterns
      PS00479 (ZF_DAG_PE_1)
6. IPR000980
   SH2 domain
   1. G3DSA:3.30.50...
      646 - 678
      GENE3D
      G3DSA:3.30.505.10 (G3DSA:3.30.505.10)

no IPR
Unintegrated signatures

1. G3DSA:3.30.60.20
   532 - 573
   GENE3D
   G3DSA:3.30.60.20 (G3DSA:3.30.60.20)
2. PTHR22826 (RHO GUAN...)
   1 - 678
   PANTHER
   PTHR22826 (RHO GUANINE EXCHANGE FACTOR-RELATED)
3. SSF50729 (PH domain...)
   410 - 551
   SUPERFAMILY
   SSF50729 (PH domain-like)
4. SSF55550 (SH2 domain)
   633 - 677
   SUPERFAMILY
   SSF55550 (SH2 domain)
5. SSF57889 (Cysteine-...)
   519 - 572
   SUPERFAMILY
   SSF57889 (Cysteine-rich domain)

### GO term prediction

#### Biological Process

GO:0007264 small GTPase mediated signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction

#### Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

#### Cellular Component

None predicted.