Protein

## EMLSAP00000004273

Length
2,125 amino acids

### Protein family membership

None predicted.

### Domains and repeats

1. Domain
   23 - 311
   - Six-bladed beta-propeller, TolB-like (IPR011042)
   347 - 625
   - Six-bladed beta-propeller, TolB-like (IPR011042)
   661 - 931
   - Six-bladed beta-propeller, TolB-like (IPR011042)
   968 - 1,253
   - Six-bladed beta-propeller, TolB-like (IPR011042)
   1,748 - 1,903
   - CRAL-TRIO domain (IPR001251)
   1,929 - 2,121
   - Rho GTPase activation protein (IPR008936)
     - Rho GTPase-activating protein domain (IPR000198)
2. Domain
   306 - 342
   - Epidermal growth factor-like domain (IPR000742)
   620 - 657
   - Epidermal growth factor-like domain (IPR000742)
   926 - 963
   - Epidermal growth factor-like domain (IPR000742)
   1,252 - 1,284
   - Epidermal growth factor-like domain (IPR000742)
3. Domain
   307 - 341
   - Insulin-like growth factor binding protein, N-terminal (IPR009030)
   609 - 658
   - Insulin-like growth factor binding protein, N-terminal (IPR009030)
4. Repeat
   49 - 271
   - LDLR class B repeat (IPR000033)
   380 - 612
   - LDLR class B repeat (IPR000033)
   684 - 919
   - LDLR class B repeat (IPR000033)
   991 - 1,030
   - LDLR class B repeat (IPR000033)
   1,048 - 1,205
   - LDLR class B repeat (IPR000033)
   1,286 - 1,327
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
5. Repeat
   1,326 - 1,402
   - Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2125

### Detailed signature matches

1. IPR011042
   Six-bladed beta-propeller, TolB-like
   1. G3DSA:2.120.1...
      661 - 931
      GENE3D
      G3DSA:2.120.10.30 (G3DSA:2.120.10.30)
      23 - 311
      GENE3D
      G3DSA:2.120.10.30 (G3DSA:2.120.10.30)
      347 - 625
      GENE3D
      G3DSA:2.120.10.30 (G3DSA:2.120.10.30)
      968 - 1,253
      GENE3D
      G3DSA:2.120.10.30 (G3DSA:2.120.10.30)
2. IPR000742
   Epidermal growth factor-like domain
   1. SM00181 (EGF)
      1,252 - 1,284
      SMART
      SM00181 (EGF)
      620 - 657
      SMART
      SM00181 (EGF)
      306 - 342
      SMART
      SM00181 (EGF)
      926 - 963
      SMART
      SM00181 (EGF)
3. IPR009030
   Insulin-like growth factor binding protein, N-terminal
   1. SSF57184 (Growth fa...)
      307 - 341
      SUPERFAMILY
      SSF57184 (Growth factor receptor domain)
      609 - 658
      SUPERFAMILY
      SSF57184 (Growth factor receptor domain)
4. IPR001251
   CRAL-TRIO domain
   1. PF13716 (CRAL_TRIO_2)
      1,764 - 1,903
      Pfam
      PF13716 (CRAL_TRIO_2)
   2. G3DSA:3.40.52...
      1,748 - 1,893
      GENE3D
      G3DSA:3.40.525.10 (G3DSA:3.40.525.10)
   3. SM00516 (SEC14)
      1,752 - 1,901
      SMART
      SM00516 (SEC14)
   4. PS50191 (CRAL_TRIO)
      1,751 - 1,893
      PROSITE profiles
      PS50191 (CRAL_TRIO)
   5. SSF52087 (CRAL/TRIO...)
      1,751 - 1,893
      SUPERFAMILY
      SSF52087 (CRAL/TRIO domain)
5. IPR008936
   Rho GTPase activation protein
   1. SSF48350 (GTPase ac...)
      1,930 - 2,121
      SUPERFAMILY
      SSF48350 (GTPase activation domain, GAP)
6. IPR000198
   Rho GTPase-activating protein domain
   1. SM00324 (RhoGAP)
      1,946 - 2,118
      SMART
      SM00324 (RhoGAP)
   2. G3DSA:1.10.55...
      1,929 - 2,121
      GENE3D
      G3DSA:1.10.555.10 (G3DSA:1.10.555.10)
   3. PF00620 (RhoGAP)
      1,949 - 2,096
      Pfam
      PF00620 (RhoGAP)
   4. PS50238 (RHOGAP)
      1,934 - 2,121
      PROSITE profiles
      PS50238 (RHOGAP)
7. IPR000033
   LDLR class B repeat
   1. PS51120 (LDLRB)
      1,068 - 1,114
      PROSITE profiles
      PS51120 (LDLRB)
      1,011 - 1,017
      PROSITE profiles
      PS51120 (LDLRB)
      69 - 116
      PROSITE profiles
      PS51120 (LDLRB)
      162 - 205
      PROSITE profiles
      PS51120 (LDLRB)
      399 - 440
      PROSITE profiles
      PS51120 (LDLRB)
      1,159 - 1,205
      PROSITE profiles
      PS51120 (LDLRB)
      206 - 248
      PROSITE profiles
      PS51120 (LDLRB)
      704 - 746
      PROSITE profiles
      PS51120 (LDLRB)
      485 - 528
      PROSITE profiles
      PS51120 (LDLRB)
      1,115 - 1,158
      PROSITE profiles
      PS51120 (LDLRB)
      877 - 919
      PROSITE profiles
      PS51120 (LDLRB)
      249 - 267
      PROSITE profiles
      PS51120 (LDLRB)
      790 - 832
      PROSITE profiles
      PS51120 (LDLRB)
      441 - 484
      PROSITE profiles
      PS51120 (LDLRB)
      833 - 874
      PROSITE profiles
      PS51120 (LDLRB)
      572 - 612
      PROSITE profiles
      PS51120 (LDLRB)
      529 - 571
      PROSITE profiles
      PS51120 (LDLRB)
      747 - 789
      PROSITE profiles
      PS51120 (LDLRB)
      117 - 161
      PROSITE profiles
      PS51120 (LDLRB)
   2. PF00058 (Ldl_recept_b)
      747 - 787
      Pfam
      PF00058 (Ldl_recept_b)
      705 - 744
      Pfam
      PF00058 (Ldl_recept_b)
      529 - 567
      Pfam
      PF00058 (Ldl_recept_b)
      401 - 438
      Pfam
      PF00058 (Ldl_recept_b)
      118 - 157
      Pfam
      PF00058 (Ldl_recept_b)
      162 - 203
      Pfam
      PF00058 (Ldl_recept_b)
      487 - 526
      Pfam
      PF00058 (Ldl_recept_b)
      441 - 482
      Pfam
      PF00058 (Ldl_recept_b)
   3. SM00135 (LY)
      142 - 185
      SMART
      SM00135 (LY)
      770 - 813
      SMART
      SM00135 (LY)
      814 - 855
      SMART
      SM00135 (LY)
      509 - 551
      SMART
      SM00135 (LY)
      727 - 769
      SMART
      SM00135 (LY)
      859 - 899
      SMART
      SM00135 (LY)
      991 - 1,030
      SMART
      SM00135 (LY)
      1,048 - 1,090
      SMART
      SM00135 (LY)
      1,095 - 1,138
      SMART
      SM00135 (LY)
      186 - 228
      SMART
      SM00135 (LY)
      684 - 726
      SMART
      SM00135 (LY)
      97 - 139
      SMART
      SM00135 (LY)
      380 - 420
      SMART
      SM00135 (LY)
      1,139 - 1,181
      SMART
      SM00135 (LY)
      421 - 463
      SMART
      SM00135 (LY)
      49 - 91
      SMART
      SM00135 (LY)
      465 - 508
      SMART
      SM00135 (LY)
      552 - 592
      SMART
      SM00135 (LY)
      229 - 271
      SMART
      SM00135 (LY)
8. IPR002172
   Low-density lipoprotein (LDL) receptor class A repeat
   1. PS50068 (LDLRA_2)
      1,362 - 1,401
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,288 - 1,326
      PROSITE profiles
      PS50068 (LDLRA_2)
      1,327 - 1,363
      PROSITE profiles
      PS50068 (LDLRA_2)
   2. SSF57424 (LDL recep...)
      1,287 - 1,325
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,327 - 1,363
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
      1,362 - 1,396
      SUPERFAMILY
      SSF57424 (LDL receptor-like module)
   3. PF00057 (Ldl_recept_a)
      1,326 - 1,362
      Pfam
      PF00057 (Ldl_recept_a)
      1,287 - 1,325
      Pfam
      PF00057 (Ldl_recept_a)
      1,363 - 1,400
      Pfam
      PF00057 (Ldl_recept_a)
   4. G3DSA:4.10.40...
      1,286 - 1,326
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,327 - 1,366
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
      1,367 - 1,396
      GENE3D
      G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
   5. PR00261 (LDLRECEPTOR)
      1,301 - 1,322
      PRINTS
      PR00261 (LDLRECEPTOR)
      1,338 - 1,359
      PRINTS
      PR00261 (LDLRECEPTOR)
      1,374 - 1,395
      PRINTS
      PR00261 (LDLRECEPTOR)
   6. SM00192 (LDLa)
      1,363 - 1,402
      SMART
      SM00192 (LDLa)
      1,328 - 1,362
      SMART
      SM00192 (LDLa)
      1,288 - 1,327
      SMART
      SM00192 (LDLa)
9. IPR023415
   Low-density lipoprotein (LDL) receptor class A, conserved site
   1. PS01209 (LDLRA_1)
      1,376 - 1,400
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,340 - 1,363
      PROSITE patterns
      PS01209 (LDLRA_1)
      1,303 - 1,328
      PROSITE patterns
      PS01209 (LDLRA_1)

no IPR
Unintegrated signatures

1. G3DSA:2.10.25.10
   932 - 967
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   626 - 658
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
   312 - 341
   GENE3D
   G3DSA:2.10.25.10 (G3DSA:2.10.25.10)
2. PF14670 (FXa_inhibi...)
   621 - 656
   Pfam
   PF14670 (FXa_inhibition)
   307 - 341
   Pfam
   PF14670 (FXa_inhibition)
3. PTHR10529 (LOW-DENS...)
   1 - 1,631
   PANTHER
   PTHR10529 (LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED)
4. PTHR10529:SF109 (LO...)
   1 - 1,631
   PANTHER
   PTHR10529:SF109 (LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6)
5. SSF57196 (EGF/Laminin)
   923 - 971
   SUPERFAMILY
   SSF57196 (EGF/Laminin)
6. SSF63825 (YWTD domain)
   23 - 270
   SUPERFAMILY
   SSF63825 (YWTD domain)
   349 - 608
   SUPERFAMILY
   SSF63825 (YWTD domain)
   968 - 1,236
   SUPERFAMILY
   SSF63825 (YWTD domain)
   662 - 919
   SUPERFAMILY
   SSF63825 (YWTD domain)
7. SignalP-noTM
   1 - 21
   SignalP euk
   SignalP-noTM (SignalP-noTM)

### GO term prediction

#### Biological Process

GO:0007165 signal transduction

#### Molecular Function

GO:0005515 protein binding

#### Cellular Component

GO:0005622 intracellular