Protein

## EMLSAP00000007337

Length
1,312 amino acids

### Protein family membership

- Ras guanine nucleotide exchange factor (IPR008937)
  - Ras GTP exchange factor, son of sevenless (IPR015759)

### Domains and repeats

1. Domain
   15 - 180
   - Histone-fold (IPR009072)
     - Histone core (IPR007125)
   424 - 551
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
   597 - 744
   - Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
2. Domain
   200 - 390
   - Dbl homology (DH) domain (IPR000219)
   736 - 978
   - Guanine-nucleotide dissociation stimulator CDC25 (IPR001895)
3. Domain
   570 - 978
   - Ras guanine nucleotide exchange factor, domain (IPR023578)

1 200 400 600 800 1000 1200 1312

### Detailed signature matches

1. IPR008937
   Ras guanine nucleotide exchange factor
   1. PTHR23113 (GUANINE ...)
      5 - 1,014
      PANTHER
      PTHR23113 (GUANINE NUCLEOTIDE EXCHANGE FACTOR)
2. IPR015759
   Ras GTP exchange factor, son of sevenless
   1. PTHR23113:SF47 (RAS...)
      5 - 1,014
      PANTHER
      PTHR23113:SF47 (RAS GTP EXCHANGE FACTOR, SON OF SEVENLESS)
3. IPR009072
   Histone-fold
   1. G3DSA:1.10.20.10
      18 - 173
      GENE3D
      G3DSA:1.10.20.10 (G3DSA:1.10.20.10)
   2. SSF47113 (Histone-fold)
      15 - 180
      SUPERFAMILY
      SSF47113 (Histone-fold)
4. IPR007125
   Histone core
   1. PF00125 (Histone)
      102 - 173
      Pfam
      PF00125 (Histone)
5. IPR000219
   Dbl homology (DH) domain
   1. SM00325 (RhoGEF)
      205 - 388
      SMART
      SM00325 (RhoGEF)
   2. SSF48065 (DBL homol...)
      200 - 386
      SUPERFAMILY
      SSF48065 (DBL homology domain (DH-domain))
   3. PF00621 (RhoGEF)
      205 - 378
      Pfam
      PF00621 (RhoGEF)
   4. PS50010 (DH_2)
      201 - 389
      PROSITE profiles
      PS50010 (DH_2)
   5. G3DSA:1.20.90...
      200 - 390
      GENE3D
      G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
6. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      424 - 551
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
7. IPR001849
   Pleckstrin homology domain
   1. PF00169 (PH)
      446 - 544
      Pfam
      PF00169 (PH)
   2. SM00233 (PH)
      444 - 550
      SMART
      SM00233 (PH)
   3. PS50003 (PH_DOMAIN)
      443 - 548
      PROSITE profiles
      PS50003 (PH_DOMAIN)
8. IPR023578
   Ras guanine nucleotide exchange factor, domain
   1. SSF48366 (Ras GEF)
      570 - 978
      SUPERFAMILY
      SSF48366 (Ras GEF)
9. IPR000651
   Ras-like guanine nucleotide exchange factor, N-terminal
   1. PF00618 (RasGEF_N)
      602 - 720
      Pfam
      PF00618 (RasGEF_N)
   2. PS50212 (RASGEF_NTER)
      598 - 744
      PROSITE profiles
      PS50212 (RASGEF_NTER)
   3. SM00229 (RasGEFN)
      597 - 744
      SMART
      SM00229 (RasGEFN)
10. IPR001895
    Guanine-nucleotide dissociation stimulator CDC25
    1. PF00617 (RasGEF)
       750 - 921
       Pfam
       PF00617 (RasGEF)
    2. PS50009 (RASGEF_CAT)
       740 - 977
       PROSITE profiles
       PS50009 (RASGEF_CAT)
    3. G3DSA:1.10.84...
       754 - 955
       GENE3D
       G3DSA:1.10.840.10 (G3DSA:1.10.840.10)
    4. SM00147 (RasGEF)
       736 - 978
       SMART
       SM00147 (RasGEF)

no IPR
Unintegrated signatures

1. G3DSA:1.20.87...
   572 - 753
   GENE3D
   G3DSA:1.20.870.10 (G3DSA:1.20.870.10)
2. SSF50729 (PH domain...)
   421 - 573
   SUPERFAMILY
   SSF50729 (PH domain-like)

### GO term prediction

#### Biological Process

GO:0007264 small GTPase mediated signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction

#### Molecular Function

GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046982 protein heterodimerization activity

#### Cellular Component

GO:0005622 intracellular