Protein

## EMLSAP00000003585

Length
901 amino acids

### Protein family membership

- Isoleucine-tRNA ligase (IPR002301)
  - Isoleucine-tRNA ligase, type 1 (IPR023585)

### Domains and repeats

1. Domain
   61 - 643
   - Aminoacyl-tRNA synthetase, class Ia (IPR002300)
   661 - 899
   - Aminoacyl-tRNA synthetase, class 1a, anticodon-binding (IPR009080)
     - Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding (IPR013155)
2. Domain
   63 - 219
   - Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
   223 - 391
   - Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain (IPR009008)
   406 - 644
   - Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)

1 100 200 300 400 500 600 700 800 901

### Detailed signature matches

1. IPR002301
   Isoleucine-tRNA ligase
   1. TIGR00392
      51 - 807
      UNKNOWN
      TIGR00392 (TIGR00392)
   2. PR00984 (TRNASYNTHILE)
      72 - 83
      PRINTS
      PR00984 (TRNASYNTHILE)
      401 - 416
      PRINTS
      PR00984 (TRNASYNTHILE)
      242 - 265
      PRINTS
      PR00984 (TRNASYNTHILE)
      527 - 540
      PRINTS
      PR00984 (TRNASYNTHILE)
2. IPR023585
   Isoleucine-tRNA ligase, type 1
   1. PTHR11946:SF9 (ISOL...)
      14 - 777
      PANTHER
      PTHR11946:SF9 (ISOLEUCYL TRNA SYNTHETASE)
3. IPR002300
   Aminoacyl-tRNA synthetase, class Ia
   1. PF00133 (tRNA-synt_1)
      61 - 643
      Pfam
      PF00133 (tRNA-synt_1)
4. IPR014729
   Rossmann-like alpha/beta/alpha sandwich fold
   1. G3DSA:3.40.50...
      63 - 219
      GENE3D
      G3DSA:3.40.50.620 (G3DSA:3.40.50.620)
      406 - 644
      GENE3D
      G3DSA:3.40.50.620 (G3DSA:3.40.50.620)
5. IPR009008
   Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
   1. G3DSA:3.90.74...
      225 - 391
      GENE3D
      G3DSA:3.90.740.10 (G3DSA:3.90.740.10)
   2. SSF50677 (ValRS/Ile...)
      223 - 389
      SUPERFAMILY
      SSF50677 (ValRS/IleRS/LeuRS editing domain)
6. IPR009080
   Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
   1. SSF47323 (Anticodon...)
      661 - 899
      SUPERFAMILY
      SSF47323 (Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases)
7. IPR013155
   Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding
   1. PF08264 (Anticodon_1)
      688 - 820
      Pfam
      PF08264 (Anticodon_1)
8. IPR001412
   Aminoacyl-tRNA synthetase, class I, conserved site
   1. PS00178 (AA_TRNA_LI...)
      79 - 90
      PROSITE patterns
      PS00178 (AA_TRNA_LIGASE_I)

no IPR
Unintegrated signatures

1. G3DSA:1.10.73...
   659 - 777
   GENE3D
   G3DSA:1.10.730.10 (G3DSA:1.10.730.10)
2. PTHR11946 (ISOLEUCY...)
   14 - 777
   PANTHER
   PTHR11946 (ISOLEUCYL, LEUCYL, TYROSYL, VALYL AND METHIONYL-TRNA SYNTHETASES)
3. SSF52374 (Nucleotid...)
   403 - 652
   SUPERFAMILY
   SSF52374 (Nucleotidylyl transferase)
   66 - 223
   SUPERFAMILY
   SSF52374 (Nucleotidylyl transferase)

### GO term prediction

#### Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation

#### Molecular Function

GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005524 ATP binding

#### Cellular Component

GO:0005737 cytoplasm