Protein

## EMLSAP00000008346

Length
1,552 amino acids

### Protein family membership

- Microcephalin (IPR022047)

### Domains and repeats

1. Domain
   242 - 262
   - Zinc finger, C2H2-like (IPR015880)
   274 - 297
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)
   314 - 342
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)
   357 - 383
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)
   398 - 426
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)
   441 - 461
   - Zinc finger, C2H2-like (IPR015880)
   468 - 489
   - Zinc finger, C2H2-like (IPR015880)
   520 - 551
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)
   552 - 579
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)
   580 - 608
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)
   652 - 740
   - High mobility group box domain (IPR009071)
   971 - 1,059
   - BRCT domain (IPR001357)
   1,357 - 1,464
   - BRCT domain (IPR001357)
   1,469 - 1,551
   - BRCT domain (IPR001357)
2. Domain
   492 - 522
   - Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
   523 - 546
   - Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
   550 - 570
   - Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
   571 - 603
   - Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
3. Domain
   494 - 521
   - Zinc finger, C2H2-like (IPR015880)
     - Zinc finger, C2H2 (IPR007087)

1 200 400 600 800 1000 1200 1400 1552

### Detailed signature matches

1. IPR022047
   Microcephalin
   1. PTHR14625 (MICROCEP...)
      1,311 - 1,552
      PANTHER
      PTHR14625 (MICROCEPHALIN)
2. IPR015880
   Zinc finger, C2H2-like
   1. SM00355 (ZnF_C2H2)
      441 - 461
      SMART
      SM00355 (ZnF_C2H2)
      580 - 603
      SMART
      SM00355 (ZnF_C2H2)
      357 - 380
      SMART
      SM00355 (ZnF_C2H2)
      274 - 297
      SMART
      SM00355 (ZnF_C2H2)
      242 - 262
      SMART
      SM00355 (ZnF_C2H2)
      468 - 489
      SMART
      SM00355 (ZnF_C2H2)
      314 - 337
      SMART
      SM00355 (ZnF_C2H2)
      552 - 574
      SMART
      SM00355 (ZnF_C2H2)
      494 - 516
      SMART
      SM00355 (ZnF_C2H2)
      523 - 546
      SMART
      SM00355 (ZnF_C2H2)
      398 - 421
      SMART
      SM00355 (ZnF_C2H2)
3. IPR007087
   Zinc finger, C2H2
   1. PF00096 (zf-C2H2)
      496 - 516
      Pfam
      PF00096 (zf-C2H2)
      524 - 546
      Pfam
      PF00096 (zf-C2H2)
   2. PS50157 (ZINC_FINGE...)
      314 - 342
      PROSITE profiles
      PS50157 (ZINC_FINGER_C2H2_2)
      357 - 383
      PROSITE profiles
      PS50157 (ZINC_FINGER_C2H2_2)
      398 - 426
      PROSITE profiles
      PS50157 (ZINC_FINGER_C2H2_2)
      520 - 551
      PROSITE profiles
      PS50157 (ZINC_FINGER_C2H2_2)
      494 - 521
      PROSITE profiles
      PS50157 (ZINC_FINGER_C2H2_2)
      552 - 579
      PROSITE profiles
      PS50157 (ZINC_FINGER_C2H2_2)
      580 - 608
      PROSITE profiles
      PS50157 (ZINC_FINGER_C2H2_2)
   3. PS00028 (ZINC_FINGE...)
      496 - 516
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
      525 - 546
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
      400 - 421
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
      582 - 603
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
      359 - 380
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
      276 - 297
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
      554 - 574
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
      316 - 337
      PROSITE patterns
      PS00028 (ZINC_FINGER_C2H2_1)
4. IPR013087
   Zinc finger C2H2-type/integrase DNA-binding domain
   1. G3DSA:3.30.16...
      492 - 522
      GENE3D
      G3DSA:3.30.160.60 (G3DSA:3.30.160.60)
      550 - 570
      GENE3D
      G3DSA:3.30.160.60 (G3DSA:3.30.160.60)
      571 - 603
      GENE3D
      G3DSA:3.30.160.60 (G3DSA:3.30.160.60)
      523 - 546
      GENE3D
      G3DSA:3.30.160.60 (G3DSA:3.30.160.60)
5. IPR009071
   High mobility group box domain
   1. SSF47095 (HMG-box)
      652 - 735
      SUPERFAMILY
      SSF47095 (HMG-box)
   2. PS50118 (HMG_BOX_2)
      661 - 729
      PROSITE profiles
      PS50118 (HMG_BOX_2)
   3. G3DSA:1.10.30.10
      653 - 740
      GENE3D
      G3DSA:1.10.30.10 (G3DSA:1.10.30.10)
   4. PF00505 (HMG_box)
      662 - 729
      Pfam
      PF00505 (HMG_box)
   5. SM00398 (HMG)
      660 - 730
      SMART
      SM00398 (HMG)
6. IPR001357
   BRCT domain
   1. PF12738 (PTCB-BRCT)
      996 - 1,041
      Pfam
      PF12738 (PTCB-BRCT)
   2. SM00292 (BRCT)
      1,357 - 1,439
      SMART
      SM00292 (BRCT)
      1,471 - 1,540
      SMART
      SM00292 (BRCT)
      974 - 1,049
      SMART
      SM00292 (BRCT)
   3. PS50172 (BRCT)
      1,380 - 1,449
      PROSITE profiles
      PS50172 (BRCT)
      1,469 - 1,550
      PROSITE profiles
      PS50172 (BRCT)
      998 - 1,059
      PROSITE profiles
      PS50172 (BRCT)
   4. SSF52113 (BRCT domain)
      1,484 - 1,551
      SUPERFAMILY
      SSF52113 (BRCT domain)
      971 - 1,057
      SUPERFAMILY
      SSF52113 (BRCT domain)
      1,367 - 1,448
      SUPERFAMILY
      SSF52113 (BRCT domain)
   5. PF00533 (BRCT)
      1,368 - 1,436
      Pfam
      PF00533 (BRCT)
   6. G3DSA:3.40.50...
      1,367 - 1,464
      GENE3D
      G3DSA:3.40.50.10190 (G3DSA:3.40.50.10190)
      988 - 1,057
      GENE3D
      G3DSA:3.40.50.10190 (G3DSA:3.40.50.10190)

no IPR
Unintegrated signatures

1. PTHR14625:SF2 (SUBF...)
   1,311 - 1,552
   PANTHER
   PTHR14625:SF2 (SUBFAMILY NOT NAMED)
2. SSF57667 (beta-beta...)
   546 - 598
   SUPERFAMILY
   SSF57667 (beta-beta-alpha zinc fingers)
   490 - 541
   SUPERFAMILY
   SSF57667 (beta-beta-alpha zinc fingers)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

#### Cellular Component

None predicted.