Protein

## EMLSAP00000000226

Length
552 amino acids

### Protein family membership

- Ribonuclease CAF1 (IPR006941)

### Domains and repeats

1. Domain
   1 - 131
   - Ribonuclease H-like domain (IPR012337)
   244 - 380
   - Ribonuclease H-like domain (IPR012337)
   402 - 485
   - Nucleotide-binding, alpha-beta plait (IPR012677)
     - Poly(A)-specific ribonuclease, RNA-binding (IPR014789)

1 100 200 300 400 500 552

### Detailed signature matches

1. IPR006941
   Ribonuclease CAF1
   1. PF04857 (CAF1)
      1 - 366
      Pfam
      PF04857 (CAF1)
2. IPR012337
   Ribonuclease H-like domain
   1. SSF53098 (Ribonucle...)
      244 - 380
      SUPERFAMILY
      SSF53098 (Ribonuclease H-like)
      1 - 131
      SUPERFAMILY
      SSF53098 (Ribonuclease H-like)
3. IPR012677
   Nucleotide-binding, alpha-beta plait
   1. G3DSA:3.30.70...
      402 - 485
      GENE3D
      G3DSA:3.30.70.330 (G3DSA:3.30.70.330)
4. IPR014789
   Poly(A)-specific ribonuclease, RNA-binding
   1. PF08675 (RNA_bind)
      408 - 482
      Pfam
      PF08675 (RNA_bind)

no IPR
Unintegrated signatures

1. G3DSA:3.30.13...
   157 - 238
   GENE3D
   G3DSA:3.30.1370.50 (G3DSA:3.30.1370.50)
2. G3DSA:3.30.42...
   243 - 381
   GENE3D
   G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
   1 - 130
   GENE3D
   G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
3. PTHR15092 (POLY(A)-...)
   1 - 518
   PANTHER
   PTHR15092 (POLY(A)-SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1)
4. PTHR15092:SF10 (POL...)
   1 - 518
   PANTHER
   PTHR15092:SF10 (POLY(A)-SPECIFIC RIBONUCLEASE (DEADENYLATION NUCLEASE))
5. SSF54928 (RNA-bindi...)
   402 - 475
   SUPERFAMILY
   SSF54928 (RNA-binding domain, RBD)
6. SSF82708 (R3H domain)
   157 - 238
   SUPERFAMILY
   SSF82708 (R3H domain)

### GO term prediction

#### Biological Process

GO:0006402 mRNA catabolic process

#### Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0046872 metal ion binding

#### Cellular Component

GO:0005634 nucleus
GO:0005737 cytoplasm