Protein

## EMLSAP00000011178

Length
1,055 amino acids

### Protein family membership

- DNA helicase (DNA repair), Rad3 type (IPR013020)

### Domains and repeats

1. Domain
   4 - 64
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   133 - 184
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   246 - 311
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   503 - 517
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   552 - 607
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   650 - 742
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
2. Domain
   9 - 337
   - Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type (IPR014013)
3. Domain
   10 - 329
   - DEAD2 (IPR010614)
     - Helicase-like, DEXD box c2 type (IPR006554)
   577 - 762
   - ATP-dependent helicase, C-terminal (IPR006555)
   926 - 1,049
   - RDD (IPR010432)

1 100 200 300 400 500 600 700 800 900 1000 1055

### Detailed signature matches

1. IPR013020
   DNA helicase (DNA repair), Rad3 type
   1. TIGR00604
      469 - 766
      UNKNOWN
      TIGR00604 (TIGR00604)
2. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      246 - 311
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      552 - 607
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      650 - 742
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      503 - 517
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      133 - 184
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      256 - 300
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      4 - 64
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
3. IPR014013
   Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
   1. PS51193 (HELICASE_A...)
      9 - 337
      PROSITE profiles
      PS51193 (HELICASE_ATP_BIND_2)
4. IPR010614
   DEAD2
   1. PF06733 (DEAD_2)
      138 - 310
      Pfam
      PF06733 (DEAD_2)
5. IPR006554
   Helicase-like, DEXD box c2 type
   1. SM00488 (DEXDc2)
      10 - 329
      SMART
      SM00488 (DEXDc2)
6. IPR006555
   ATP-dependent helicase, C-terminal
   1. SM00491 (HELICc2)
      595 - 748
      SMART
      SM00491 (HELICc2)
   2. PF13307 (Helicase_C_2)
      577 - 762
      Pfam
      PF13307 (Helicase_C_2)
7. IPR010432
   RDD
   1. PF06271 (RDD)
      926 - 1,049
      Pfam
      PF06271 (RDD)

no IPR
Unintegrated signatures

1. Coil
   810 - 831
   COILS
   Coil (Coil)
   777 - 798
   COILS
   Coil (Coil)
2. G3DSA:3.40.50...
   505 - 513
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   5 - 61
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   133 - 182
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   254 - 319
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
3. PTHR11472 (DNA REPA...)
   1 - 849
   PANTHER
   PTHR11472 (DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER)
4. PTHR11472:SF6 (BRCA...)
   1 - 849
   PANTHER
   PTHR11472:SF6 (BRCA1 INTERACTING PROTEIN C-TERMINAL HELICASE 1 BRIP1)
5. TMhelix
   965 - 987
   TMHMM
   TMhelix (TMhelix)
   1,033 - 1,050
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006139 nucleobase-containing compound metabolic process

#### Molecular Function

GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

#### Cellular Component

None predicted.