Protein

## EMLSAP00000011039

Length
875 amino acids

### Protein family membership

- E3 ubiquitin-protein ligase, SMURF1 type (IPR024928)

### Domains and repeats

1. Domain
   12 - 151
   - C2 domain (IPR000008)
   276 - 313
   - WW domain (IPR001202)
   381 - 418
   - WW domain (IPR001202)
   422 - 457
   - WW domain (IPR001202)
   481 - 875
   - HECT (IPR000569)
2. Domain
   312 - 345
   - WW domain (IPR001202)

1 100 200 300 400 500 600 700 800 875

### Detailed signature matches

1. IPR024928
   E3 ubiquitin-protein ligase, SMURF1 type
   1. PIRSF001569 (E3_ub_...)
      18 - 875
      PIRSF
      PIRSF001569 (E3_ub_ligase_SMURF1)
2. IPR000008
   C2 domain
   1. PF00168 (C2)
      47 - 107
      Pfam
      PF00168 (C2)
   2. PS50004 (C2)
      12 - 109
      PROSITE profiles
      PS50004 (C2)
   3. SSF49562 (C2 domain...)
      30 - 151
      SUPERFAMILY
      SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
   4. SM00239 (C2)
      29 - 124
      SMART
      SM00239 (C2)
3. IPR001202
   WW domain
   1. SSF51045 (WW domain)
      381 - 418
      SUPERFAMILY
      SSF51045 (WW domain)
      422 - 456
      SUPERFAMILY
      SSF51045 (WW domain)
      313 - 345
      SUPERFAMILY
      SSF51045 (WW domain)
      276 - 311
      SUPERFAMILY
      SSF51045 (WW domain)
   2. PS01159 (WW_DOMAIN_1)
      318 - 343
      PROSITE patterns
      PS01159 (WW_DOMAIN_1)
      390 - 415
      PROSITE patterns
      PS01159 (WW_DOMAIN_1)
      430 - 455
      PROSITE patterns
      PS01159 (WW_DOMAIN_1)
      286 - 311
      PROSITE patterns
      PS01159 (WW_DOMAIN_1)
   3. PF00397 (WW)
      314 - 343
      Pfam
      PF00397 (WW)
      387 - 415
      Pfam
      PF00397 (WW)
      426 - 455
      Pfam
      PF00397 (WW)
      282 - 311
      Pfam
      PF00397 (WW)
   4. PS50020 (WW_DOMAIN_2)
      424 - 457
      PROSITE profiles
      PS50020 (WW_DOMAIN_2)
      312 - 345
      PROSITE profiles
      PS50020 (WW_DOMAIN_2)
      280 - 313
      PROSITE profiles
      PS50020 (WW_DOMAIN_2)
      384 - 417
      PROSITE profiles
      PS50020 (WW_DOMAIN_2)
   5. SM00456 (WW)
      425 - 457
      SMART
      SM00456 (WW)
      281 - 313
      SMART
      SM00456 (WW)
      314 - 345
      SMART
      SM00456 (WW)
      385 - 417
      SMART
      SM00456 (WW)
4. IPR000569
   HECT
   1. SSF56204 (Hect, E3 ...)
      481 - 869
      SUPERFAMILY
      SSF56204 (Hect, E3 ligase catalytic domain)
   2. SM00119 (HECTc)
      519 - 875
      SMART
      SM00119 (HECTc)
   3. PS50237 (HECT)
      521 - 875
      PROSITE profiles
      PS50237 (HECT)
   4. PF00632 (HECT)
      571 - 874
      Pfam
      PF00632 (HECT)

no IPR
Unintegrated signatures

1. G3DSA:2.20.70.10
   313 - 343
   GENE3D
   G3DSA:2.20.70.10 (G3DSA:2.20.70.10)
   422 - 457
   GENE3D
   G3DSA:2.20.70.10 (G3DSA:2.20.70.10)
   379 - 418
   GENE3D
   G3DSA:2.20.70.10 (G3DSA:2.20.70.10)
   278 - 311
   GENE3D
   G3DSA:2.20.70.10 (G3DSA:2.20.70.10)
2. G3DSA:2.60.40...
   14 - 147
   GENE3D
   G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
3. G3DSA:3.30.21...
   646 - 720
   GENE3D
   G3DSA:3.30.2160.10 (G3DSA:3.30.2160.10)
4. PTHR11254 (HECT DOM...)
   47 - 875
   PANTHER
   PTHR11254 (HECT DOMAIN UBIQUITIN-PROTEIN LIGASE)
5. PTHR11254:SF65 (NED...)
   47 - 875
   PANTHER
   PTHR11254:SF65 (NEDD-4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0004842 ubiquitin-protein ligase activity
GO:0005515 protein binding

#### Cellular Component

None predicted.