Protein

## EMLSAP00000010184

Length
2,188 amino acids

### Protein family membership

- Myotubularin protein (IPR022096)

### Domains and repeats

1. Domain
   1 - 89
   - uDENN domain (IPR005113)
   131 - 322
   - DENN domain (IPR001194)
   378 - 447
   - dDENN domain (IPR005112)
   935 - 1,018
   - GRAM domain (IPR004182)
   1,214 - 1,705
   - Myotubularin-like phosphatase domain (IPR010569)
   1,962 - 2,013
   - Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219)
   2,083 - 2,188
   - Pleckstrin homology-like domain (IPR011993)
     - Pleckstrin homology domain (IPR001849)
2. Domain
   1,240 - 1,808
   - Myotubularin phosphatase domain (IPR017906)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2188

### Detailed signature matches

1. IPR022096
   Myotubularin protein
   1. PF12335 (SBF2)
      569 - 819
      Pfam
      PF12335 (SBF2)
2. IPR005113
   uDENN domain
   1. SM00800 (uDENN)
      1 - 89
      SMART
      SM00800 (uDENN)
   2. PF03456 (uDENN)
      28 - 89
      Pfam
      PF03456 (uDENN)
   3. PS50946 (UDENN)
      21 - 89
      PROSITE profiles
      PS50946 (UDENN)
3. IPR001194
   DENN domain
   1. PS50211 (DENN)
      131 - 322
      PROSITE profiles
      PS50211 (DENN)
   2. PF02141 (DENN)
      132 - 321
      Pfam
      PF02141 (DENN)
   3. SM00799 (DENN)
      131 - 322
      SMART
      SM00799 (DENN)
4. IPR005112
   dDENN domain
   1. SM00801 (dDENN)
      378 - 447
      SMART
      SM00801 (dDENN)
   2. PF03455 (dDENN)
      378 - 447
      Pfam
      PF03455 (dDENN)
   3. PS50947 (DDENN)
      378 - 447
      PROSITE profiles
      PS50947 (DDENN)
5. IPR004182
   GRAM domain
   1. SM00568 (GRAM)
      935 - 1,018
      SMART
      SM00568 (GRAM)
   2. PF02893 (GRAM)
      936 - 1,016
      Pfam
      PF02893 (GRAM)
6. IPR010569
   Myotubularin-like phosphatase domain
   1. PF06602 (Myotub-rel...)
      1,214 - 1,705
      Pfam
      PF06602 (Myotub-related)
7. IPR017906
   Myotubularin phosphatase domain
   1. PS51339 (PPASE_MYOT...)
      1,240 - 1,808
      PROSITE profiles
      PS51339 (PPASE_MYOTUBULARIN)
8. IPR002219
   Protein kinase C-like, phorbol ester/diacylglycerol binding
   1. PS50081 (ZF_DAG_PE_2)
      1,962 - 2,012
      PROSITE profiles
      PS50081 (ZF_DAG_PE_2)
   2. PF00130 (C1_1)
      1,963 - 2,013
      Pfam
      PF00130 (C1_1)
   3. SM00109 (C1)
      1,963 - 2,012
      SMART
      SM00109 (C1)
   4. PS00479 (ZF_DAG_PE_1)
      1,963 - 2,012
      PROSITE patterns
      PS00479 (ZF_DAG_PE_1)
9. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      2,083 - 2,187
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
10. IPR001849
    Pleckstrin homology domain
    1. PF00169 (PH)
       2,087 - 2,187
       Pfam
       PF00169 (PH)
    2. SM00233 (PH)
       2,086 - 2,188
       SMART
       SM00233 (PH)
    3. PS50003 (PH_DOMAIN)
       2,085 - 2,188
       PROSITE profiles
       PS50003 (PH_DOMAIN)

no IPR
Unintegrated signatures

1. G3DSA:3.30.60.20
   1,960 - 2,020
   GENE3D
   G3DSA:3.30.60.20 (G3DSA:3.30.60.20)
2. PTHR10807 (MYOTUBUL...)
   471 - 2,179
   PANTHER
   PTHR10807 (MYOTUBULARIN-RELATED)
3. PTHR10807:SF1 (SET ...)
   471 - 2,179
   PANTHER
   PTHR10807:SF1 (SET BINDING FACTOR)
4. SSF50729 (PH domain...)
   2,082 - 2,187
   SUPERFAMILY
   SSF50729 (PH domain-like)
   969 - 1,080
   SUPERFAMILY
   SSF50729 (PH domain-like)
5. SSF52799 ((Phosphot...)
   1,255 - 1,326
   SUPERFAMILY
   SSF52799 ((Phosphotyrosine protein) phosphatases II)
   1,360 - 1,381
   SUPERFAMILY
   SSF52799 ((Phosphotyrosine protein) phosphatases II)
   1,495 - 1,708
   SUPERFAMILY
   SSF52799 ((Phosphotyrosine protein) phosphatases II)
   1,756 - 1,810
   SUPERFAMILY
   SSF52799 ((Phosphotyrosine protein) phosphatases II)
6. SSF57889 (Cysteine-...)
   1,959 - 2,014
   SUPERFAMILY
   SSF57889 (Cysteine-rich domain)

### GO term prediction

#### Biological Process

GO:0016311 dephosphorylation
GO:0035556 intracellular signal transduction

#### Molecular Function

GO:0016791 phosphatase activity

#### Cellular Component

None predicted.