Protein

## EMLSAP00000001842

Length
574 amino acids

### Protein family membership

- Adaptor protein Cbl (IPR024162)

### Domains and repeats

1. Domain
   32 - 338
   - Adaptor protein Cbl, PTB domain (IPR024159)
2. Domain
   36 - 162
   - Adaptor protein Cbl, N-terminal helical (IPR003153)
   164 - 251
   - EF-hand domain pair (IPR011992)
     - Adaptor protein Cbl, EF hand-like (IPR014741)
   352 - 417
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
     - Zinc finger, RING-type (IPR001841)
3. Domain
   251 - 337
   - SH2 domain (IPR000980)
     - Adaptor protein Cbl, SH2-like (IPR014742)

1 100 200 300 400 500 574

### Detailed signature matches

1. IPR024162
   Adaptor protein Cbl
   1. PTHR23007 (CBL)
      38 - 424
      PANTHER
      PTHR23007 (CBL)
2. IPR024159
   Adaptor protein Cbl, PTB domain
   1. PS51506 (CBL_PTB)
      32 - 338
      PROSITE profiles
      PS51506 (CBL_PTB)
3. IPR003153
   Adaptor protein Cbl, N-terminal helical
   1. SSF47668 (N-termina...)
      37 - 156
      SUPERFAMILY
      SSF47668 (N-terminal domain of cbl (N-cbl))
   2. G3DSA:1.20.93...
      37 - 157
      GENE3D
      G3DSA:1.20.930.20 (G3DSA:1.20.930.20)
   3. PF02262 (Cbl_N)
      36 - 162
      Pfam
      PF02262 (Cbl_N)
4. IPR011992
   EF-hand domain pair
   1. G3DSA:1.10.23...
      164 - 251
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
5. IPR014741
   Adaptor protein Cbl, EF hand-like
   1. PF02761 (Cbl_N2)
      166 - 249
      Pfam
      PF02761 (Cbl_N2)
6. IPR000980
   SH2 domain
   1. G3DSA:3.30.50...
      252 - 337
      GENE3D
      G3DSA:3.30.505.10 (G3DSA:3.30.505.10)
7. IPR014742
   Adaptor protein Cbl, SH2-like
   1. PF02762 (Cbl_N3)
      251 - 336
      Pfam
      PF02762 (Cbl_N3)
8. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10
      352 - 417
      GENE3D
      G3DSA:3.30.40.10 (G3DSA:3.30.40.10)
9. IPR001841
   Zinc finger, RING-type
   1. PS50089 (ZF_RING_2)
      368 - 408
      PROSITE profiles
      PS50089 (ZF_RING_2)
   2. SM00184 (RING)
      368 - 407
      SMART
      SM00184 (RING)
10. IPR017907
    Zinc finger, RING-type, conserved site
    1. PS00518 (ZF_RING_1)
       383 - 392
       PROSITE patterns
       PS00518 (ZF_RING_1)

no IPR
Unintegrated signatures

1. Coil
   104 - 125
   COILS
   Coil (Coil)
2. PF13920 (zf-C3HC4_3)
   367 - 412
   Pfam
   PF13920 (zf-C3HC4_3)
3. PTHR23007:SF9 (SUBF...)
   38 - 424
   PANTHER
   PTHR23007:SF9 (SUBFAMILY NOT NAMED)
4. SSF47473 (EF-hand)
   166 - 250
   SUPERFAMILY
   SSF47473 (EF-hand)
5. SSF55550 (SH2 domain)
   251 - 337
   SUPERFAMILY
   SSF55550 (SH2 domain)
6. SSF57850 (RING/U-box)
   343 - 422
   SUPERFAMILY
   SSF57850 (RING/U-box)

### GO term prediction

#### Biological Process

GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

#### Molecular Function

GO:0001784 phosphotyrosine binding
GO:0004842 ubiquitin-protein ligase activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding

#### Cellular Component

GO:0005634 nucleus