Protein

## EMLSAP00000006855

Length
2,188 amino acids

### Protein family membership

- Histone H3-K56 acetyltransferase, RTT109 (IPR013178)

### Domains and repeats

1. Domain
   239 - 336
   - Zinc finger, TAZ-type (IPR000197)
   529 - 614
   - Coactivator CBP, KIX domain (IPR003101)
   860 - 994
   - Bromodomain (IPR001487)
   1,505 - 1,548
   - Zinc finger, ZZ-type (IPR000433)
   1,566 - 1,655
   - Zinc finger, TAZ-type (IPR000197)
   1,807 - 1,914
   - Nuclear receptor coactivator, interlocking (IPR009110)
     - Nuclear receptor coactivator, CREB-bp-like, interlocking (IPR014744)
2. Domain
   984 - 1,027
   - Domain of unknown function DUF902, CREBbp (IPR010303)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2188

### Detailed signature matches

1. IPR013178
   Histone H3-K56 acetyltransferase, RTT109
   1. PF08214 (KAT11)
      1,137 - 1,450
      Pfam
      PF08214 (KAT11)
2. IPR000197
   Zinc finger, TAZ-type
   1. PS50134 (ZF_TAZ)
      1,566 - 1,647
      PROSITE profiles
      PS50134 (ZF_TAZ)
      241 - 331
      PROSITE profiles
      PS50134 (ZF_TAZ)
   2. G3DSA:1.20.10...
      241 - 336
      GENE3D
      G3DSA:1.20.1020.10 (G3DSA:1.20.1020.10)
      1,566 - 1,655
      GENE3D
      G3DSA:1.20.1020.10 (G3DSA:1.20.1020.10)
   3. SM00551 (ZnF_TAZ)
      1,567 - 1,645
      SMART
      SM00551 (ZnF_TAZ)
      242 - 331
      SMART
      SM00551 (ZnF_TAZ)
   4. SSF57933 (TAZ domain)
      239 - 334
      SUPERFAMILY
      SSF57933 (TAZ domain)
      1,569 - 1,650
      SUPERFAMILY
      SSF57933 (TAZ domain)
   5. PF02135 (zf-TAZ)
      1,572 - 1,644
      Pfam
      PF02135 (zf-TAZ)
      247 - 330
      Pfam
      PF02135 (zf-TAZ)
3. IPR003101
   Coactivator CBP, KIX domain
   1. PS50952 (KIX)
      529 - 608
      PROSITE profiles
      PS50952 (KIX)
   2. PF02172 (KIX)
      532 - 609
      Pfam
      PF02172 (KIX)
   3. G3DSA:1.10.24...
      532 - 614
      GENE3D
      G3DSA:1.10.246.20 (G3DSA:1.10.246.20)
   4. SSF47040 (Kix domai...)
      531 - 613
      SUPERFAMILY
      SSF47040 (Kix domain of CBP (creb binding protein))
4. IPR001487
   Bromodomain
   1. PR00503 (BROMODOMAIN)
      915 - 931
      PRINTS
      PR00503 (BROMODOMAIN)
      931 - 949
      PRINTS
      PR00503 (BROMODOMAIN)
      949 - 968
      PRINTS
      PR00503 (BROMODOMAIN)
      899 - 912
      PRINTS
      PR00503 (BROMODOMAIN)
   2. SM00297 (BROMO)
      876 - 987
      SMART
      SM00297 (BROMO)
   3. SSF47370 (Bromodomain)
      860 - 989
      SUPERFAMILY
      SSF47370 (Bromodomain)
   4. G3DSA:1.20.92...
      860 - 994
      GENE3D
      G3DSA:1.20.920.10 (G3DSA:1.20.920.10)
   5. PS50014 (BROMODOMAIN_2)
      896 - 968
      PROSITE profiles
      PS50014 (BROMODOMAIN_2)
   6. PF00439 (Bromodomain)
      891 - 973
      Pfam
      PF00439 (Bromodomain)
5. IPR010303
   Domain of unknown function DUF902, CREBbp
   1. PF06001 (DUF902)
      984 - 1,027
      Pfam
      PF06001 (DUF902)
6. IPR000433
   Zinc finger, ZZ-type
   1. PS50135 (ZF_ZZ_2)
      1,505 - 1,548
      PROSITE profiles
      PS50135 (ZF_ZZ_2)
   2. SM00291 (ZnF_ZZ)
      1,505 - 1,546
      SMART
      SM00291 (ZnF_ZZ)
   3. PS01357 (ZF_ZZ_1)
      1,511 - 1,536
      PROSITE patterns
      PS01357 (ZF_ZZ_1)
   4. PF00569 (ZZ)
      1,506 - 1,546
      Pfam
      PF00569 (ZZ)
7. IPR009110
   Nuclear receptor coactivator, interlocking
   1. SSF69125 (Nuclear r...)
      1,867 - 1,914
      SUPERFAMILY
      SSF69125 (Nuclear receptor coactivator interlocking domain)
8. IPR014744
   Nuclear receptor coactivator, CREB-bp-like, interlocking
   1. G3DSA:1.10.16...
      1,868 - 1,914
      GENE3D
      G3DSA:1.10.1630.10 (G3DSA:1.10.1630.10)
   2. PF09030 (Creb_binding)
      1,807 - 1,914
      Pfam
      PF09030 (Creb_binding)
9. IPR018359
   Bromodomain, conserved site
   1. PS00633 (BROMODOMAIN_1)
      901 - 960
      PROSITE patterns
      PS00633 (BROMODOMAIN_1)
10. IPR019786
    Zinc finger, PHD-type, conserved site
    1. PS01359 (ZF_PHD_1)
       1,032 - 1,106
       PROSITE patterns
       PS01359 (ZF_PHD_1)

no IPR
Unintegrated signatures

1. Coil
   1,343 - 1,374
   COILS
   Coil (Coil)
   1,987 - 2,008
   COILS
   Coil (Coil)
   1,375 - 1,381
   COILS
   Coil (Coil)
   600 - 621
   COILS
   Coil (Coil)
2. PTHR13808 (CBP/P300...)
   1 - 2,028
   PANTHER
   PTHR13808 (CBP/P300-RELATED)
3. PTHR13808:SF1 (SUBF...)
   1 - 2,028
   PANTHER
   PTHR13808:SF1 (SUBFAMILY NOT NAMED)
4. SSF57850 (RING/U-box)
   1,488 - 1,544
   SUPERFAMILY
   SSF57850 (RING/U-box)

### GO term prediction

#### Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation

#### Molecular Function

GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding

#### Cellular Component

GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus