Protein

## EMLSAP00000007712

Length
844 amino acids

### Protein family membership

- Phosphoinositide phospholipase C family (IPR001192)
  - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4/NorpA (IPR028404)

### Domains and repeats

1. Domain
   15 - 138
   - Pleckstrin homology-like domain (IPR011993)
   199 - 245
   - EF-hand domain pair (IPR011992)
   251 - 346
   - Phospholipase C, phosphatidylinositol-specific , X domain (IPR000909)
   406 - 522
   - Phospholipase C, phosphatidylinositol-specific, Y domain (IPR001711)
   529 - 660
   - C2 domain (IPR000008)
2. Domain
   254 - 536
   - PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (IPR017946)

1 100 200 300 400 500 600 700 844

### Detailed signature matches

1. IPR001192
   Phosphoinositide phospholipase C family
   1. PR00390 (PHPHLIPASEC)
      244 - 262
      PRINTS
      PR00390 (PHPHLIPASEC)
      628 - 638
      PRINTS
      PR00390 (PHPHLIPASEC)
      270 - 290
      PRINTS
      PR00390 (PHPHLIPASEC)
      460 - 481
      PRINTS
      PR00390 (PHPHLIPASEC)
      481 - 499
      PRINTS
      PR00390 (PHPHLIPASEC)
   2. PTHR10336 (PHOSPHOI...)
      1 - 844
      PANTHER
      PTHR10336 (PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN)
2. IPR028404
   1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4/NorpA
   1. PTHR10336:SF8 (1-PH...)
      1 - 844
      PANTHER
      PTHR10336:SF8 (1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4)
3. IPR011993
   Pleckstrin homology-like domain
   1. G3DSA:2.30.29.30
      15 - 138
      GENE3D
      G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
4. IPR011992
   EF-hand domain pair
   1. G3DSA:1.10.23...
      199 - 245
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
5. IPR000909
   Phospholipase C, phosphatidylinositol-specific , X domain
   1. PF00388 (PI-PLC-X)
      251 - 331
      Pfam
      PF00388 (PI-PLC-X)
   2. PS50007 (PIPLC_X_DO...)
      254 - 331
      PROSITE profiles
      PS50007 (PIPLC_X_DOMAIN)
   3. SM00148 (PLCXc)
      254 - 346
      SMART
      SM00148 (PLCXc)
6. IPR017946
   PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
   1. G3DSA:3.20.20...
      331 - 348
      GENE3D
      G3DSA:3.20.20.190 (G3DSA:3.20.20.190)
      401 - 536
      GENE3D
      G3DSA:3.20.20.190 (G3DSA:3.20.20.190)
      254 - 330
      GENE3D
      G3DSA:3.20.20.190 (G3DSA:3.20.20.190)
   2. SSF51695 (PLC-like ...)
      254 - 523
      SUPERFAMILY
      SSF51695 (PLC-like phosphodiesterases)
7. IPR001711
   Phospholipase C, phosphatidylinositol-specific, Y domain
   1. PS50008 (PIPLC_Y_DO...)
      406 - 522
      PROSITE profiles
      PS50008 (PIPLC_Y_DOMAIN)
   2. PF00387 (PI-PLC-Y)
      406 - 522
      Pfam
      PF00387 (PI-PLC-Y)
   3. SM00149 (PLCYc)
      406 - 522
      SMART
      SM00149 (PLCYc)
8. IPR000008
   C2 domain
   1. PS50004 (C2)
      529 - 627
      PROSITE profiles
      PS50004 (C2)
   2. SSF49562 (C2 domain...)
      546 - 660
      SUPERFAMILY
      SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
   3. SM00239 (C2)
      543 - 642
      SMART
      SM00239 (C2)
9. IPR009535
   Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
   1. PF06631 (DUF1154)
      733 - 775
      Pfam
      PF06631 (DUF1154)

no IPR
Unintegrated signatures

1. G3DSA:1.20.12...
   733 - 843
   GENE3D
   G3DSA:1.20.1230.10 (G3DSA:1.20.1230.10)
2. G3DSA:2.60.40...
   545 - 661
   GENE3D
   G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
3. SSF47473 (EF-hand)
   150 - 253
   SUPERFAMILY
   SSF47473 (EF-hand)
4. SSF50729 (PH domain...)
   12 - 140
   SUPERFAMILY
   SSF50729 (PH domain-like)
5. SSF69989 (C-termina...)
   735 - 844
   SUPERFAMILY
   SSF69989 (C-terminal domain of PLC-beta)

### GO term prediction

#### Biological Process

GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007602 phototransduction
GO:0035556 intracellular signal transduction

#### Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity

#### Cellular Component

None predicted.