Protein

## EMLSAP00000010606

Length
439 amino acids

### Protein family membership

- Serine hydroxymethyltransferase (IPR001085)

### Domains and repeats

1. Domain
   12 - 436
   - Pyridoxal phosphate-dependent transferase (IPR015424)
2. Domain
   44 - 308
   - Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
   309 - 381
   - Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (IPR015422)
   382 - 436
   - Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (IPR015422)

1 50 100 150 200 250 300 350 400 439

### Detailed signature matches

1. IPR001085
   Serine hydroxymethyltransferase
   1. MF_00051 (SHMT)
      14 - 435
      HAMAP
      MF_00051 (SHMT)
   2. PTHR11680 (SERINE H...)
      11 - 439
      PANTHER
      PTHR11680 (SERINE HYDROXYMETHYLTRANSFERASE)
   3. PF00464 (SHMT)
      16 - 385
      Pfam
      PF00464 (SHMT)
   4. PIRSF000412 (SHMT)
      1 - 436
      PIRSF
      PIRSF000412 (SHMT)
2. IPR015424
   Pyridoxal phosphate-dependent transferase
   1. SSF53383 (PLP-depen...)
      12 - 436
      SUPERFAMILY
      SSF53383 (PLP-dependent transferases)
3. IPR015421
   Pyridoxal phosphate-dependent transferase, major region, subdomain 1
   1. G3DSA:3.40.64...
      44 - 308
      GENE3D
      G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
4. IPR015422
   Pyridoxal phosphate-dependent transferase, major region, subdomain 2
   1. G3DSA:3.90.11...
      309 - 381
      GENE3D
      G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
      382 - 436
      GENE3D
      G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
5. IPR019798
   Serine hydroxymethyltransferase, pyridoxal phosphate binding site
   1. PS00096 (SHMT)
      238 - 254
      PROSITE patterns
      PS00096 (SHMT)

no IPR
Unintegrated signatures

1. Coil
   410 - 431
   COILS
   Coil (Coil)

### GO term prediction

#### Biological Process

GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process

#### Molecular Function

GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0030170 pyridoxal phosphate binding

#### Cellular Component

None predicted.