Protein

## EMLSAP00000001002

Length
563 amino acids

### Protein family membership

- Neurotransmitter-gated ion-channel (IPR006201)
  - Nicotinic acetylcholine receptor (IPR002394)

### Domains and repeats

1. Domain
   22 - 238
   - Neurotransmitter-gated ion-channel ligand-binding (IPR006202)
2. Domain
   238 - 533
   - Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)
3. Domain
   238 - 345
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)
   482 - 534
   - Nicotinic acetylcholine-gated receptor, transmembrane domain (IPR027361)

1 100 200 300 400 500 563

### Detailed signature matches

1. IPR006201
   Neurotransmitter-gated ion-channel
   1. PTHR18945 (NEUROTRA...)
      17 - 524
      PANTHER
      PTHR18945 (NEUROTRANSMITTER GATED ION CHANNEL)
   2. PR00252 (NRIONCHANNEL)
      103 - 114
      PRINTS
      PR00252 (NRIONCHANNEL)
      147 - 161
      PRINTS
      PR00252 (NRIONCHANNEL)
      232 - 244
      PRINTS
      PR00252 (NRIONCHANNEL)
      70 - 86
      PRINTS
      PR00252 (NRIONCHANNEL)
   3. TIGR00860
      22 - 524
      UNKNOWN
      TIGR00860 (TIGR00860)
2. IPR002394
   Nicotinic acetylcholine receptor
   1. PR00254 (NICOTINICR)
      127 - 145
      PRINTS
      PR00254 (NICOTINICR)
      91 - 105
      PRINTS
      PR00254 (NICOTINICR)
      57 - 73
      PRINTS
      PR00254 (NICOTINICR)
      109 - 121
      PRINTS
      PR00254 (NICOTINICR)
3. IPR006202
   Neurotransmitter-gated ion-channel ligand-binding
   1. PF02931 (Neur_chan_LBD)
      24 - 238
      Pfam
      PF02931 (Neur_chan_LBD)
   2. SSF63712 (Nicotinic...)
      22 - 237
      SUPERFAMILY
      SSF63712 (Nicotinic receptor ligand binding domain-like)
   3. G3DSA:2.70.17...
      24 - 237
      GENE3D
      G3DSA:2.70.170.10 (G3DSA:2.70.170.10)
4. IPR027361
   Nicotinic acetylcholine-gated receptor, transmembrane domain
   1. G3DSA:1.20.12...
      238 - 345
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
      482 - 534
      GENE3D
      G3DSA:1.20.120.370 (G3DSA:1.20.120.370)
5. IPR006029
   Neurotransmitter-gated ion-channel transmembrane domain
   1. SSF90112 (Neurotran...)
      238 - 383
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
      463 - 533
      SUPERFAMILY
      SSF90112 (Neurotransmitter-gated ion-channel transmembrane pore)
   2. PF02932 (Neur_chan_...)
      245 - 523
      Pfam
      PF02932 (Neur_chan_memb)
6. IPR018000
   Neurotransmitter-gated ion-channel, conserved site
   1. PS00236 (NEUROTR_IO...)
      147 - 161
      PROSITE patterns
      PS00236 (NEUROTR_ION_CHANNEL)

no IPR
Unintegrated signatures

1. PS51257 (PROKAR_LIP...)
   1 - 18
   PROSITE profiles
   PS51257 (PROKAR_LIPOPROTEIN)
2. PTHR18945:SF88 (ACE...)
   17 - 524
   PANTHER
   PTHR18945:SF88 (ACETYLCHOLINE RECEPTOR PROTEIN ALPHA, INVERTEBRATE)
3. SignalP-noTM
   1 - 19
   SignalP euk
   SignalP-noTM (SignalP-noTM)
4. TMhelix
   306 - 328
   TMHMM
   TMhelix (TMhelix)
   274 - 296
   TMHMM
   TMhelix (TMhelix)
   507 - 529
   TMHMM
   TMhelix (TMhelix)
   240 - 262
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006810 transport
GO:0006811 ion transport

#### Molecular Function

GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005216 ion channel activity
GO:0005230 extracellular ligand-gated ion channel activity

#### Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045211 postsynaptic membrane