Protein

## EMLSAP00000007819

Length
436 amino acids

### Protein family membership

- A/G-specific adenine glycosylase MutY (IPR005760)

### Domains and repeats

1. Domain
   44 - 261
   - DNA glycosylase (IPR011257)
     - HhH-GPD domain (IPR003265)
   291 - 433
   - NUDIX hydrolase domain-like (IPR015797)
2. Domain
   172 - 262
   - Helix-turn-helix, base-excision DNA repair, C-terminal (IPR023170)

1 50 100 150 200 250 300 350 400 436

### Detailed signature matches

1. IPR005760
   A/G-specific adenine glycosylase MutY
   1. PTHR10359:SF1 (A/G-...)
      2 - 430
      PANTHER
      PTHR10359:SF1 (A/G-SPECIFIC ADENINE DNA GLYCOSYLASE)
2. IPR011257
   DNA glycosylase
   1. SSF48150 (DNA-glyco...)
      44 - 261
      SUPERFAMILY
      SSF48150 (DNA-glycosylase)
   2. G3DSA:1.10.34...
      75 - 171
      GENE3D
      G3DSA:1.10.340.30 (G3DSA:1.10.340.30)
3. IPR003265
   HhH-GPD domain
   1. PF00730 (HhH-GPD)
      84 - 216
      Pfam
      PF00730 (HhH-GPD)
   2. SM00478 (ENDO3c)
      88 - 239
      SMART
      SM00478 (ENDO3c)
4. IPR023170
   Helix-turn-helix, base-excision DNA repair, C-terminal
   1. G3DSA:1.10.16...
      172 - 262
      GENE3D
      G3DSA:1.10.1670.10 (G3DSA:1.10.1670.10)
5. IPR015797
   NUDIX hydrolase domain-like
   1. G3DSA:3.90.79.10
      308 - 433
      GENE3D
      G3DSA:3.90.79.10 (G3DSA:3.90.79.10)
   2. SSF55811 (Nudix)
      291 - 394
      SUPERFAMILY
      SSF55811 (Nudix)
6. IPR000445
   Helix-hairpin-helix motif
   1. PF00633 (HHH)
      149 - 177
      Pfam
      PF00633 (HHH)
7. IPR004036
   Endonuclease III-like, conserved site-2
   1. PS01155 (ENDONUCLEA...)
      151 - 180
      PROSITE patterns
      PS01155 (ENDONUCLEASE_III_2)
8. IPR003651
   Endonuclease III-like, iron-sulphur cluster loop motif
   1. SM00525 (FES)
      240 - 260
      SMART
      SM00525 (FES)

no IPR
Unintegrated signatures

1. PF14815 (NUDIX_4)
   315 - 430
   Pfam
   PF14815 (NUDIX_4)
2. PTHR10359 (A/G-SPEC...)
   2 - 430
   PANTHER
   PTHR10359 (A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III)

### GO term prediction

#### Biological Process

GO:0006281 DNA repair
GO:0006284 base-excision repair

#### Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0019104 DNA N-glycosylase activity
GO:0051539 4 iron, 4 sulfur cluster binding

#### Cellular Component

None predicted.