Protein

## EMLSAP00000010789

Length
5,433 amino acids

### Protein family membership

- Na+/H+ exchanger (IPR004709)

### Domains and repeats

1. Domain
   1,134 - 1,310
   - Chromo domain-like (IPR016197)
     - Chromo domain/shadow (IPR000953)
       - Chromo domain (IPR023780)
   1,317 - 1,389
   - Chromo domain-like (IPR016197)
     - Chromo domain/shadow (IPR000953)
       - Chromo domain (IPR023780)
   1,424 - 1,710
   - SNF2-related (IPR000330)
   1,747 - 1,898
   - Helicase, C-terminal (IPR001650)
   2,981 - 3,026
   - BRK domain (IPR006576)
2. Domain
   1,404 - 1,642
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   1,644 - 1,943
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   3,167 - 3,204
   - Heat shock chaperonin-binding (IPR006636)
   3,217 - 3,263
   - Heat shock chaperonin-binding (IPR006636)
   3,277 - 3,314
   - Heat shock chaperonin-binding (IPR006636)
   3,315 - 3,349
   - Heat shock chaperonin-binding (IPR006636)
   3,481 - 3,513
   - Heat shock chaperonin-binding (IPR006636)
   3,516 - 3,553
   - Heat shock chaperonin-binding (IPR006636)
   3,566 - 3,603
   - Heat shock chaperonin-binding (IPR006636)
   3,606 - 3,644
   - Heat shock chaperonin-binding (IPR006636)
   4,161 - 4,191
   - Heat shock chaperonin-binding (IPR006636)
   4,883 - 5,332
   - Cation/H+ exchanger (IPR006153)
3. Domain
   1,417 - 1,619
   - Helicase, superfamily 1/2, ATP-binding domain (IPR014001)

1 500 1000 1500 2000 2500 3000 3500 4000 4500 5000 5433

### Detailed signature matches

1. IPR004709
   Na+/H+ exchanger
   1. PR01084 (NAHEXCHNGR)
      5,013 - 5,021
      PRINTS
      PR01084 (NAHEXCHNGR)
      4,998 - 5,012
      PRINTS
      PR01084 (NAHEXCHNGR)
      5,054 - 5,064
      PRINTS
      PR01084 (NAHEXCHNGR)
      4,984 - 4,995
      PRINTS
      PR01084 (NAHEXCHNGR)
   2. TIGR00840
      4,978 - 5,386
      UNKNOWN
      TIGR00840 (TIGR00840)
2. IPR016197
   Chromo domain-like
   1. SSF54160 (Chromo do...)
      1,261 - 1,309
      SUPERFAMILY
      SSF54160 (Chromo domain-like)
      1,317 - 1,384
      SUPERFAMILY
      SSF54160 (Chromo domain-like)
3. IPR000953
   Chromo domain/shadow
   1. SM00298 (CHROMO)
      1,331 - 1,389
      SMART
      SM00298 (CHROMO)
      1,134 - 1,310
      SMART
      SM00298 (CHROMO)
   2. PS50013 (CHROMO_2)
      1,333 - 1,376
      PROSITE profiles
      PS50013 (CHROMO_2)
4. IPR023780
   Chromo domain
   1. PF00385 (Chromo)
      1,334 - 1,384
      Pfam
      PF00385 (Chromo)
      1,261 - 1,300
      Pfam
      PF00385 (Chromo)
5. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      1,404 - 1,642
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      1,644 - 1,943
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
6. IPR014001
   Helicase, superfamily 1/2, ATP-binding domain
   1. SM00487 (DEXDc)
      1,417 - 1,619
      SMART
      SM00487 (DEXDc)
   2. PS51192 (HELICASE_A...)
      1,433 - 1,607
      PROSITE profiles
      PS51192 (HELICASE_ATP_BIND_1)
7. IPR000330
   SNF2-related
   1. PF00176 (SNF2_N)
      1,424 - 1,710
      Pfam
      PF00176 (SNF2_N)
8. IPR001650
   Helicase, C-terminal
   1. PF00271 (Helicase_C)
      1,778 - 1,857
      Pfam
      PF00271 (Helicase_C)
   2. SM00490 (HELICc)
      1,773 - 1,857
      SMART
      SM00490 (HELICc)
   3. PS51194 (HELICASE_CTER)
      1,747 - 1,898
      PROSITE profiles
      PS51194 (HELICASE_CTER)
9. IPR006576
   BRK domain
   1. PF07533 (BRK)
      2,981 - 3,025
      Pfam
      PF07533 (BRK)
   2. SM00592 (BRK)
      2,982 - 3,026
      SMART
      SM00592 (BRK)
10. IPR006636
    Heat shock chaperonin-binding
    1. SM00727 (STI1)
       3,217 - 3,263
       SMART
       SM00727 (STI1)
       4,161 - 4,191
       SMART
       SM00727 (STI1)
       3,516 - 3,553
       SMART
       SM00727 (STI1)
       3,277 - 3,314
       SMART
       SM00727 (STI1)
       3,606 - 3,644
       SMART
       SM00727 (STI1)
       3,167 - 3,204
       SMART
       SM00727 (STI1)
       3,566 - 3,603
       SMART
       SM00727 (STI1)
       3,315 - 3,349
       SMART
       SM00727 (STI1)
       3,481 - 3,513
       SMART
       SM00727 (STI1)
11. IPR006153
    Cation/H+ exchanger
    1. PF00999 (Na_H_Excha...)
       4,883 - 5,332
       Pfam
       PF00999 (Na_H_Exchanger)

no IPR
Unintegrated signatures

1. Coil
   4,654 - 4,675
   COILS
   Coil (Coil)
   1,202 - 1,223
   COILS
   Coil (Coil)
   4,688 - 4,716
   COILS
   Coil (Coil)
   4,534 - 4,562
   COILS
   Coil (Coil)
   4,569 - 4,625
   COILS
   Coil (Coil)
   2,343 - 2,372
   COILS
   Coil (Coil)
   4,800 - 4,828
   COILS
   Coil (Coil)
2. G3DSA:2.40.50.40
   1,324 - 1,385
   GENE3D
   G3DSA:2.40.50.40 (G3DSA:2.40.50.40)
   1,236 - 1,314
   GENE3D
   G3DSA:2.40.50.40 (G3DSA:2.40.50.40)
3. G3DSA:3.40.50...
   1,739 - 1,895
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   1,418 - 1,608
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
4. PTHR10799 (SWI/SNF-...)
   113 - 2,310
   PANTHER
   PTHR10799 (SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY-RELATED)
5. PTHR10799:SF293 (SU...)
   113 - 2,310
   PANTHER
   PTHR10799:SF293 (SUBFAMILY NOT NAMED)
6. SSF160481 (BRK doma...)
   2,979 - 3,041
   SUPERFAMILY
   SSF160481 (BRK domain-like)
7. TMhelix
   5,078 - 5,100
   TMHMM
   TMhelix (TMhelix)
   4,984 - 5,001
   TMHMM
   TMhelix (TMhelix)
   5,013 - 5,035
   TMHMM
   TMhelix (TMhelix)
   5,243 - 5,265
   TMHMM
   TMhelix (TMhelix)
   5,050 - 5,069
   TMHMM
   TMhelix (TMhelix)
   5,177 - 5,199
   TMHMM
   TMhelix (TMhelix)
   5,126 - 5,148
   TMHMM
   TMhelix (TMhelix)
   5,214 - 5,236
   TMHMM
   TMhelix (TMhelix)
   5,315 - 5,337
   TMHMM
   TMhelix (TMhelix)
   5,280 - 5,302
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0055085 transmembrane transport

#### Molecular Function

GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015299 solute:hydrogen antiporter activity
GO:0015385 sodium:hydrogen antiporter activity
GO:0016817 hydrolase activity, acting on acid anhydrides

#### Cellular Component

GO:0016021 integral component of membrane