Protein

## EMLSAP00000000277

Length
1,369 amino acids

### Protein family membership

- DNA-directed RNA polymerase III largest subunit (IPR015700)

### Domains and repeats

1. Domain
   12 - 357
   - RNA polymerase Rpb1, domain 1 (IPR007080)
   359 - 527
   - RNA polymerase, alpha subunit (IPR000722)
   532 - 707
   - RNA polymerase Rpb1, domain 3 (IPR007066)
2. Domain
   249 - 557
   - RNA polymerase, N-terminal (IPR006592)
   738 - 838
   - RNA polymerase Rpb1, domain 4 (IPR007083)
   845 - 1,295
   - RNA polymerase Rpb1, domain 5 (IPR007081)

1 200 400 600 800 1000 1200 1369

### Detailed signature matches

1. IPR015700
   DNA-directed RNA polymerase III largest subunit
   1. PTHR19376:SF15 (DNA...)
      1 - 1,365
      PANTHER
      PTHR19376:SF15 (DNA-DIRECTED RNA POLYMERASE III LARGEST SUBUNIT)
2. IPR007080
   RNA polymerase Rpb1, domain 1
   1. PF04997 (RNA_pol_Rp...)
      12 - 357
      Pfam
      PF04997 (RNA_pol_Rpb1_1)
3. IPR006592
   RNA polymerase, N-terminal
   1. SM00663 (RPOLA_N)
      249 - 557
      SMART
      SM00663 (RPOLA_N)
4. IPR000722
   RNA polymerase, alpha subunit
   1. PF00623 (RNA_pol_Rp...)
      359 - 527
      Pfam
      PF00623 (RNA_pol_Rpb1_2)
5. IPR007066
   RNA polymerase Rpb1, domain 3
   1. PF04983 (RNA_pol_Rp...)
      532 - 707
      Pfam
      PF04983 (RNA_pol_Rpb1_3)
6. IPR007083
   RNA polymerase Rpb1, domain 4
   1. PF05000 (RNA_pol_Rp...)
      738 - 838
      Pfam
      PF05000 (RNA_pol_Rpb1_4)
7. IPR007081
   RNA polymerase Rpb1, domain 5
   1. PF04998 (RNA_pol_Rp...)
      845 - 1,295
      Pfam
      PF04998 (RNA_pol_Rpb1_5)

no IPR
Unintegrated signatures

1. Coil
   880 - 901
   COILS
   Coil (Coil)
2. G3DSA:2.40.40.20
   364 - 391
   GENE3D
   G3DSA:2.40.40.20 (G3DSA:2.40.40.20)
   460 - 530
   GENE3D
   G3DSA:2.40.40.20 (G3DSA:2.40.40.20)
3. G3DSA:3.30.14...
   392 - 458
   GENE3D
   G3DSA:3.30.1490.180 (G3DSA:3.30.1490.180)
4. PTHR19376 (DNA-DIRE...)
   1 - 1,365
   PANTHER
   PTHR19376 (DNA-DIRECTED RNA POLYMERASE)
5. SSF64484 (beta and ...)
   7 - 189
   SUPERFAMILY
   SSF64484 (beta and beta-prime subunits of DNA dependent RNA-polymerase)
   216 - 1,345
   SUPERFAMILY
   SSF64484 (beta and beta-prime subunits of DNA dependent RNA-polymerase)

### GO term prediction

#### Biological Process

GO:0006351 transcription, DNA-templated

#### Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0008270 zinc ion binding
GO:0032549 ribonucleoside binding

#### Cellular Component

GO:0005634 nucleus