Protein

## EMLSAP00000010820

Length
1,340 amino acids

### Protein family membership

- Methylmalonate-semialdehyde dehydrogenase (IPR010061)

### Domains and repeats

1. Domain
   63 - 201
   - Ankyrin repeat-containing domain (IPR020683)
   843 - 1,101
   - Aldehyde dehydrogenase, N-terminal (IPR016162)
   1,102 - 1,282
   - Aldehyde dehydrogenase, C-terminal (IPR016163)
2. Domain
   841 - 1,318
   - Aldehyde/histidinol dehydrogenase (IPR016161)
     - Aldehyde dehydrogenase domain (IPR015590)
3. Repeat
   69 - 101
   - Ankyrin repeat (IPR002110)
   102 - 134
   - Ankyrin repeat (IPR002110)
   135 - 169
   - Ankyrin repeat (IPR002110)

1 200 400 600 800 1000 1200 1340

### Detailed signature matches

1. IPR010061
   Methylmalonate-semialdehyde dehydrogenase
   1. TIGR01722
      846 - 1,318
      UNKNOWN
      TIGR01722 (TIGR01722)
   2. PTHR11699:SF27 (MET...)
      814 - 1,329
      PANTHER
      PTHR11699:SF27 (METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE)
2. IPR020683
   Ankyrin repeat-containing domain
   1. PS50297 (ANK_REP_RE...)
      69 - 177
      PROSITE profiles
      PS50297 (ANK_REP_REGION)
   2. G3DSA:1.25.40.20
      69 - 201
      GENE3D
      G3DSA:1.25.40.20 (G3DSA:1.25.40.20)
   3. PF12796 (Ank_2)
      111 - 178
      Pfam
      PF12796 (Ank_2)
   4. SSF48403 (Ankyrin r...)
      63 - 179
      SUPERFAMILY
      SSF48403 (Ankyrin repeat)
3. IPR016161
   Aldehyde/histidinol dehydrogenase
   1. SSF53720 (ALDH-like)
      841 - 1,318
      SUPERFAMILY
      SSF53720 (ALDH-like)
4. IPR016162
   Aldehyde dehydrogenase, N-terminal
   1. G3DSA:3.40.60...
      843 - 1,101
      GENE3D
      G3DSA:3.40.605.10 (G3DSA:3.40.605.10)
5. IPR015590
   Aldehyde dehydrogenase domain
   1. PF00171 (Aldedh)
      854 - 1,317
      Pfam
      PF00171 (Aldedh)
6. IPR016163
   Aldehyde dehydrogenase, C-terminal
   1. G3DSA:3.40.30...
      1,102 - 1,282
      GENE3D
      G3DSA:3.40.309.10 (G3DSA:3.40.309.10)
7. IPR002110
   Ankyrin repeat
   1. SM00248 (ANK)
      102 - 131
      SMART
      SM00248 (ANK)
      135 - 169
      SMART
      SM00248 (ANK)
      69 - 98
      SMART
      SM00248 (ANK)
   2. PS50088 (ANK_REPEAT)
      135 - 167
      PROSITE profiles
      PS50088 (ANK_REPEAT)
      102 - 134
      PROSITE profiles
      PS50088 (ANK_REPEAT)
      69 - 101
      PROSITE profiles
      PS50088 (ANK_REPEAT)
8. IPR016160
   Aldehyde dehydrogenase, conserved site
   1. PS00070 (ALDEHYDE_D...)
      1,115 - 1,126
      PROSITE patterns
      PS00070 (ALDEHYDE_DEHYDR_CYS)

no IPR
Unintegrated signatures

1. PF13857 (Ank_5)
   66 - 108
   Pfam
   PF13857 (Ank_5)
2. PTHR11699 (ALDEHYDE...)
   814 - 1,329
   PANTHER
   PTHR11699 (ALDEHYDE DEHYDROGENASE-RELATED)

### GO term prediction

#### Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

#### Cellular Component

None predicted.