Protein

## EMLSAP00000010993

Length
1,328 amino acids

### Protein family membership

- Lon protease (IPR027065)

- tRNA modification GTPase MnmE (IPR004520)

- Vacuolar fusion protein MON1 (IPR004353)

### Domains and repeats

1. Domain
   4 - 186
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
     - ATPase, AAA-type, core (IPR003959)
   460 - 540
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   576 - 745
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
2. Domain
   171 - 375
   - Ribosomal protein S5 domain 2-type fold (IPR020568)
     - Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721)
     - Peptidase S16, Lon C-terminal (IPR008269)
   386 - 509
   - GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 (IPR027266)
     - GTP-binding protein TrmE, N-terminal (IPR018948)
   510 - 570
   - tRNA modification GTPase MnmE domain 2 (IPR027368)
   636 - 660
   - tRNA modification GTPase MnmE domain 2 (IPR027368)
   762 - 810
   - tRNA modification GTPase MnmE domain 2 (IPR027368)
3. Domain
   605 - 716
   - Small GTP-binding protein domain (IPR005225)
4. Domain
   607 - 714
   - GTP binding domain (IPR006073)

1 200 400 600 800 1000 1200 1328

### Detailed signature matches

1. IPR027065
   Lon protease
   1. PTHR10046 (ATP DEPE...)
      1 - 375
      PANTHER
      PTHR10046 (ATP DEPENDENT LON PROTEASE FAMILY MEMBER)
2. IPR004520
   tRNA modification GTPase MnmE
   1. MF_00379 (GTPase_MnmE)
      388 - 848
      HAMAP
      MF_00379 (GTPase_MnmE)
3. IPR004353
   Vacuolar fusion protein MON1
   1. PR01546 (YEAST73DUF)
      993 - 1,021
      PRINTS
      PR01546 (YEAST73DUF)
      1,051 - 1,072
      PRINTS
      PR01546 (YEAST73DUF)
      1,022 - 1,034
      PRINTS
      PR01546 (YEAST73DUF)
      970 - 984
      PRINTS
      PR01546 (YEAST73DUF)
      1,308 - 1,328
      PRINTS
      PR01546 (YEAST73DUF)
      1,156 - 1,182
      PRINTS
      PR01546 (YEAST73DUF)
      936 - 956
      PRINTS
      PR01546 (YEAST73DUF)
      1,101 - 1,117
      PRINTS
      PR01546 (YEAST73DUF)
      1,126 - 1,149
      PRINTS
      PR01546 (YEAST73DUF)
      1,077 - 1,090
      PRINTS
      PR01546 (YEAST73DUF)
      918 - 935
      PRINTS
      PR01546 (YEAST73DUF)
      1,295 - 1,308
      PRINTS
      PR01546 (YEAST73DUF)
      1,279 - 1,293
      PRINTS
      PR01546 (YEAST73DUF)
   2. PF03164 (Mon1)
      910 - 1,328
      Pfam
      PF03164 (Mon1)
4. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      4 - 139
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      460 - 540
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      576 - 745
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      91 - 186
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
5. IPR003959
   ATPase, AAA-type, core
   1. PF00004 (AAA)
      7 - 87
      Pfam
      PF00004 (AAA)
6. IPR020568
   Ribosomal protein S5 domain 2-type fold
   1. SSF54211 (Ribosomal...)
      198 - 375
      SUPERFAMILY
      SSF54211 (Ribosomal protein S5 domain 2-like)
7. IPR008269
   Peptidase S16, Lon C-terminal
   1. PF05362 (Lon_C)
      171 - 375
      Pfam
      PF05362 (Lon_C)
8. IPR014721
   Ribosomal protein S5 domain 2-type fold, subgroup
   1. G3DSA:3.30.23...
      192 - 375
      GENE3D
      G3DSA:3.30.230.10 (G3DSA:3.30.230.10)
9. IPR027266
   GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
   1. G3DSA:3.30.13...
      386 - 509
      GENE3D
      G3DSA:3.30.1360.120 (G3DSA:3.30.1360.120)
10. IPR018948
    GTP-binding protein TrmE, N-terminal
    1. PF10396 (TrmE_N)
       389 - 508
       Pfam
       PF10396 (TrmE_N)
11. IPR027368
    tRNA modification GTPase MnmE domain 2
    1. G3DSA:1.20.12...
       762 - 810
       GENE3D
       G3DSA:1.20.120.430 (G3DSA:1.20.120.430)
       510 - 570
       GENE3D
       G3DSA:1.20.120.430 (G3DSA:1.20.120.430)
       636 - 660
       GENE3D
       G3DSA:1.20.120.430 (G3DSA:1.20.120.430)
12. IPR005225
    Small GTP-binding protein domain
    1. TIGR00231
       605 - 716
       UNKNOWN
       TIGR00231 (TIGR00231)
13. IPR006073
    GTP binding domain
    1. PF01926 (MMR_HSR1)
       607 - 714
       Pfam
       PF01926 (MMR_HSR1)
14. IPR008268
    Peptidase S16, active site
    1. PS01046 (LON_SER)
       285 - 293
       PROSITE patterns
       PS01046 (LON_SER)

no IPR
Unintegrated signatures

1. Coil
   869 - 899
   COILS
   Coil (Coil)
2. G3DSA:1.10.8.60
   100 - 186
   GENE3D
   G3DSA:1.10.8.60 (G3DSA:1.10.8.60)
3. G3DSA:3.40.50...
   2 - 99
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   604 - 635
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
4. PTHR10046:SF23 (LON...)
   1 - 375
   PANTHER
   PTHR10046:SF23 (LON PROTEASE HOMOLOG, MITOCHONDRIAL)

### GO term prediction

#### Biological Process

GO:0006184 GTP catabolic process
GO:0006400 tRNA modification
GO:0006508 proteolysis
GO:0030163 protein catabolic process

#### Molecular Function

GO:0003924 GTPase activity
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding

#### Cellular Component

GO:0005622 intracellular