Protein

## EMLSAP00000009162

Length
630 amino acids

### Protein family membership

- Small GTPase superfamily (IPR001806)
  - Small GTPase superfamily, Rab type (IPR003579)
  - Small GTPase superfamily, mitochondrial Rho (IPR021181)
  - Small GTPase superfamily, Ras type (IPR020849)
  - Small GTPase superfamily, Rho type (IPR003578)

### Domains and repeats

1. Domain
   4 - 147
   - MIRO (IPR020860)
   226 - 313
   - EF hand associated, type-2 (IPR013567)
   422 - 630
   - Mitochondrial Rho-like (IPR013684)
     - MIRO (IPR020860)
2. Domain
   10 - 172
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   189 - 224
   - EF-hand domain (IPR002048)
   311 - 346
   - EF-hand domain (IPR002048)
   347 - 423
   - EF hand associated, type-1 (IPR013566)
   426 - 585
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
3. Domain
   183 - 272
   - EF-hand domain pair (IPR011992)
   314 - 343
   - EF-hand domain pair (IPR011992)

1 100 200 300 400 500 630

### Detailed signature matches

1. IPR001806
   Small GTPase superfamily
   1. PR00449 (RASTRNSFRMNG)
      149 - 171
      PRINTS
      PR00449 (RASTRNSFRMNG)
      11 - 32
      PRINTS
      PR00449 (RASTRNSFRMNG)
      114 - 127
      PRINTS
      PR00449 (RASTRNSFRMNG)
   2. PF00071 (Ras)
      12 - 171
      Pfam
      PF00071 (Ras)
2. IPR020849
   Small GTPase superfamily, Ras type
   1. SM00173 (RAS)
      8 - 174
      SMART
      SM00173 (RAS)
3. IPR021181
   Small GTPase superfamily, mitochondrial Rho
   1. PTHR24072:SF69 (MIT...)
      8 - 542
      PANTHER
      PTHR24072:SF69 (MITOCHONDRIAL RHO GTPASE)
4. IPR003579
   Small GTPase superfamily, Rab type
   1. SM00175 (RAB)
      11 - 174
      SMART
      SM00175 (RAB)
5. IPR003578
   Small GTPase superfamily, Rho type
   1. SM00174 (RHO)
      13 - 174
      SMART
      SM00174 (RHO)
6. IPR020860
   MIRO
   1. PS51423 (MIRO)
      4 - 147
      PROSITE profiles
      PS51423 (MIRO)
      422 - 630
      PROSITE profiles
      PS51423 (MIRO)
7. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      10 - 172
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      426 - 585
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
8. IPR011992
   EF-hand domain pair
   1. G3DSA:1.10.23...
      183 - 272
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
      314 - 343
      GENE3D
      G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
9. IPR002048
   EF-hand domain
   1. PS50222 (EF_HAND_2)
      311 - 346
      PROSITE profiles
      PS50222 (EF_HAND_2)
      189 - 224
      PROSITE profiles
      PS50222 (EF_HAND_2)
10. IPR013567
    EF hand associated, type-2
    1. PF08356 (EF_assoc_2)
       226 - 313
       Pfam
       PF08356 (EF_assoc_2)
11. IPR013566
    EF hand associated, type-1
    1. PF08355 (EF_assoc_1)
       347 - 423
       Pfam
       PF08355 (EF_assoc_1)
12. IPR013684
    Mitochondrial Rho-like
    1. PF08477 (Miro)
       430 - 543
       Pfam
       PF08477 (Miro)
13. IPR018247
    EF-Hand 1, calcium-binding site
    1. PS00018 (EF_HAND_1)
       324 - 336
       PROSITE patterns
       PS00018 (EF_HAND_1)

no IPR
Unintegrated signatures

1. G3DSA:3.40.50...
   9 - 175
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   426 - 564
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
2. PTHR24072 (RHO FAMI...)
   8 - 542
   PANTHER
   PTHR24072 (RHO FAMILY GTPASE)
3. SSF47473 (EF-hand)
   314 - 375
   SUPERFAMILY
   SSF47473 (EF-hand)
   178 - 272
   SUPERFAMILY
   SSF47473 (EF-hand)
4. TMhelix
   604 - 623
   TMHMM
   TMhelix (TMhelix)

### GO term prediction

#### Biological Process

GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0019725 cellular homeostasis

#### Molecular Function

GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding

#### Cellular Component

GO:0005622 intracellular
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane