Query:    4 LAEIE-KISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQI-ILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSSFDTK 542
            +AE E + +CA+C   ANQRCTGCHVTFYCSREHQK HWKKHK  CC++KIC+S  +GR++ ATRDL+PGEL+L E P +IAPMA T P+CL+C+ PVDG   C  CGWPMC+++C  S  H+PEC +   RG PI   V  N  P P+YE +A LRC+Y+K+ + + ++ L++LE H ++R  NG+  +D++ +L++IR FF++ ++   D+++L L GILFVNSHEVPVT +P  ALY N+SL+EH+CV+NASKHFD + ++ IR A+ I+KG+HI+I YSDP+WG  NRQQHL+E+KFF C C RCQDP EL T+FSS+RCP CPA   G+L S++P +  S + C+ C+  E+  +VNAVIRSIGEEL+ LEKG+PEACL+F+KKHSQNLH +HFYLMDVKLALCQ+IG++      +      F   EKDL+ KQKLC E++ +AN ISPG+SRLRGV++YELQ+  A YARKKF+  EI+ DH KNI+QEV++YL ECIQIFS+E  C+QEG+LA++ARL L E+E  + S ++K
Sbjct:    1 MAEAESQFTCAYCQIQANQRCTGCHVTFYCSREHQKLHWKKHKNRCCSYKICNSEXLGRYLXATRDLKPGELILMEAPTIIAPMAVTPPVCLSCYAPVDGRYMCPLCGWPMCNEICRNSPAHIPECRITAERGSPIKIAVTINK-PFPLYEVVALLRCLYMKEKSSEKYKALIRLEPHTKERIKNGKYSRDKMTMLRVIREFFSVPSTRFPDEDILALCGILFVNSHEVPVTMSPSQALYQNASLLEHSCVNNASKHFDMNCNILIRVAIPIKKGEHISIMYSDPIWGTVNRQQHLLETKFFTCRCIRCQDPTELNTHFSSIRCPGCPA---GFLVSLDPFNYESDWKCETCNRVETPRFVNAVIRSIGEELISLEKGSPEACLSFVKKHSQNLHPHHFYLMDVKLALCQMIGQSSYGTGSEI-----FELHEKDLLQKQKLCTEILEVANKISPGVSRLRGVVMYELQAXXAAYARKKFSNGEISSDHMKNILQEVKKYLQECIQIFSYEPTCLQEGKLAAIARLDLVELETFMDSVESK 532          

Query:   12 CAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFK-----ICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLAC---FKPVDGSIRCTTCGWPMCSDLCIGSSNHV-PECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKR---KLNGRVDKDQIILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESE 514
            C  C   A   C+ C   FYC REHQK HW  H   C  FK     I  +  +GR++VA  D+  G L+ +E PL+I P   T  +CL C    K    +  C  C WPMCS  C  S  H   EC++ +  G  +   + +    N +Y  I  LR + LK  N   +++ ++ ++H  +R   ++  +V+K++++   I  F  +  S  SD E+L+  G L  N  E+      +  LY   S++ H C  N    F+ +  + + + V I+KG+ I  TY+ P+W   +R++HL  SK F C C RC DP E GT  S+  C  C     G +  ++PLD  S + C+ C     +  V   I S+ +EL  +++ NPE    F+K+++  L   +    +++L L  L     +          D +T +  L+ K  +C +L+++AN + PG S+ RG +L E+QS   I  ++  A   I+    K+I  E  ++L E  ++   E E
Sbjct:  137 CIVCGELAKNFCSSCKYVFYCKREHQKSHWSSHSKECAHFKALPYRIERNPRLGRYLVAKDDISEGSLIFNEPPLVIGPRQLTKAVCLXCHNELKDKKDTYPCRRCTWPMCSRSCSDSPVHANAECSILSYGGVKV--NIDAFGTANMMYACITVLRALSLK--NDHKWQEYLKFDSHLNERMPTQVYQQVNKEKVVF-FIHYFLKL-LSKFSDLEILEACGKLDTNCFEIRQFGKNLRGLYRIGSIMSHECTPNTRHTFEENYDINVYSTVDIKKGEIICATYTQPLWCTLSRREHLNMSKCFWCRCKRCSDPTEFGTYLSAFSCSEC----GGKMLPLDPLDQKSNWKCEKCSHTLESTTVRHGIESMMDELKSIDRTNPENLEDFLKRYATLLPETNQLTREIQLGLVSLFKNRRNE---------DLKTTQ--LLRKAFMCRQLLTVANRVDPGFSKWRGELLLEMQSANVILGQRALAEGRISNIQAKDIFDENMKHLKEADRVLCIEPE 630          

Query:   10 ISCAFCNGDANQRCTGCHVTFYCSREHQKQHW-KKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIRCTTCGWPMCSDL-CIGSSNHV-PECT-LNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQI-ILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRC----PSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKH-SQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYE---LQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGR 520
            ++C  C    +Q C+GCH   YCS+EHQK HW + HK  CCA+K+      GR ++ TRD+ PGE++  E+P+ + P  +  P+CL C+K V+G+  C+ C WPMC ++ C  +  H   EC  L +   KPI D +       PIY+ +  LRC+ +K+  PD +  L  +E+H E RK       +Q+ I+K I        ++   ++ +D   ++ VN+ E+      +  LY  ++++  NC  N     D +   ++ A   I KG  I  TY+  + G   R+  L ESK+F C C RC DP EL ++FS+L C    PS      G++ S N L+ ++ + C  C    S + V  + + +  E ++ E    +    F+K    + LH NH+ ++D K  L + +          S    D   R +  I K+++  +++ + ++I+PG  R+R +++ E   +  ++A +        EI L+  + II      L EC+ I  FE+    EG+
Sbjct:   27 LNCPECGKCVSQFCSGCHSVGYCSKEHQKNHWLQGHKNECCAYKLVKKEGHGRILIVTRDIEPGEVIFEESPITVGPKQFCQPVCLGCYKNVNGTSICSGCNWPMCGNIECEKAPIHSKKECALLADCHLKPIID-LNKPEKDLPIYQFLTALRCLLVKEFRPDNWSILESMESHTELRKNEESYRVNQVNIVKFILERIKYDTTVEDINKCID---VMDVNAFEIRSHEFSIAGLYPMTAMMNSNCSPNTQNSIDENYICRVMAITRIPKGSEINSTYTRTLSGTLYRRNQLKESKYFDCKCERCCDPTELNSHFSTLLCQAILPSISKTCKGFVYSENSLNTNASWICRACGAVMSHEEVTELTQKLEVE-IEKEFLTIDDYENFLKNRLLKFLHPNHYIIVDFKFILMKAL----------SRAEYDPEIRIQREIRKKRIIEDILDVHSLITPGYFRIRAMLVSERCMVMMSIAFHNLSNSNKNEIFLEECERIIDG----LEECVSILRFENTNSVEGQ 531          

Query:   12 CAFCNGDANQR-----CTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKR-----KLNGRVDKDQIILKMI--RRFFNISASLISDD----EVLDLQGILFVNSHEV-PVTPT---PVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTR-EKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSSFDT 541
            C FC  +  +      C  C + +YCS EH   H  +H   C  F +  S   GR++VA RD+ P EL+LSE P ++ P +  +P CL CF+ VDGS  C+ CG P+C   C     H PEC         I  E   +S        +  LR + +K+S+P+ F K+  L  H E+R     ++N ++    + LK +   + FN +    S+D    E+  + GIL  N  +  P+ P    P +ALY    LI H C +N +     D  L++R+ + I+KG+ I   Y     GN  R+Q + +  FF C C RC D  ELGT  S + C  C    NGYL  IN L+  S +SC++C    +   ++ +I +I  ++  +E    +     +  + + LH NH+ ++D        I  NL  V     T+    TR EK+   K +LCM ++     + PG ++ RG IL E+   L + +++    K IT   F   +    R L E  +  +     + E  ++S+  LK    ED +S  +T
Sbjct:   68 CFFCGNEEEEDNHLTLCPFCKIVYYCSEEHYIIH--RHSNRCFPFIVKRSKRFGRYMVAARDINPLELILSEQPAVVGPYSKKLPGCLNCFRLVDGSYYCSKCGVPVCDKECEIGDLHRPECGYFQKNNFVIKKENHYSSQA-----CVTPLRMLLMKKSDPNTFRKIDMLMDHIEERVVINKQVNIQLLNIILFLKEVSSSKEFNQNEVSTSNDFDQKEIQRMLGILKTNGMKFEPLGPERGCPGVALYPVYCLINHACFNNTNYVKFPDFHLELRSQIPIKKGEQIFTRYVSSTIGNLRRRQDIKQYWFFDCECQRCIDRTELGTYMSGINCKHC---KNGYLLPINSLNYESDWSCNNCDVIVNYKTISDIIDTIESQVRSIEHETIDELEEMLYHYQKLLHPNHYIVID--------IMHNLIHVYAAKETL----TRPEKER--KIQLCMSVLETLGRVDPGYTKWRGTILQEMIYPLMMVSKEDHEYKRITEREFHKRLNICARKLAEAKKCLTGGFTKLTENSVSSI--LKKPIDEDNVSKSNT 592          

Query:   12 CAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKI-CSSSVIGRHVVATRDLRPGELVLSENPLLIAP-MAYTVPICLACFKPVDGSIRC--TTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDK--DQIILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLA----------LYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKF 481
            C  C   A  +C  C + +YCSREHQK+ W+ HK  C A++I  + S +GR +   RD++ G+L++S  P +I P + Y  P CL C   +D  +      C +P+CS  C    +   EC L           +     P+   E +  LR   LK+SNP ++EKL+ LE H ++ K +    K  ++ +LK ++   +    +  D E+  L GI   NS E+  T   +            LY   SL+ H+CV NA    ++   + + AAV I     I   Y  P+     RQ+ L E+KFF+C C RC+DP ELGT  SSL C  C    +         +      C     E  A  +   +     +L ++ K     C+ F+K++   L   H +++ +K+ L  L   N    +   N        +K  I +Q  C +++++ +II PG+S  RG++L+EL +     A  +F
Sbjct:   10 CEHCEAPAKLQCGACELVWYCSREHQKRKWRDHKMICIAYRIEDTQSALGRQLRTARDVKQGDLIISAPPCVIGPRLDYPKPSCLGCHVILDEKMSLCEGGCEYPLCSSECHRKFHSEEECKL-----------LEKIKSPDKRCEIVTILRFALLKKSNPRIYEKLILLEDHVDEIKASSTRWKNIEEGVLKHLKEIKS-DLDIEEDQELERLVGIWITNSFELERTDQQLFGEKRAGESIQGLYDVPSLMNHSCVGNARLVINSGMYIDVYAAVPISNKAPITFNYISPLEDYDRRQKILKENKFFECKCERCEDPTELGTFSSSLLCQVCKKSPSTRTKDSKNYECR---DCSEVMSERDAMKIANSLMKGKNKLHRIGKAWV-TCIPFLKEYQDILWETHTFIIXIKMXLVXLXXSNXAISQMDENG-------KKIQIERQSYCNDVLAVQDIIDPGMSLGRGLVLHELHAARVFLANYRF 472          

Query:   51 FKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPV--DGSIRCTTCGWPMCSDLCIGSSNHVP-ECTLNNSRGKPIPDE--VGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNG-RVDKDQIILKMIRRFFNISASLISDDEVLDLQGILFVNSHEV--PVTPTP-----VLALYLNSSLIEHNCVSNASKHF---DTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNP--EACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARK 479
            +KI  +  +GR++VATRD++PGE VL E PL   P     PICL C+ PV  +    C  CG+PMCS  C     H   EC   ++    +  +  +  N     +Y AI+ +R + LK+ +P  +  +    +H E R+ +     KD   L+ I+    IS      D +  + GI  VN  E+  P+  +      +  ++  +S+  H+CVSN   +F   +    + ++A V I++GD I  +Y++P+     RQ  L   KFFQC C RC+DP E+ T  S+L C  C     G + S N  +I+S + CD C    S D V  V      E+ +++K NP  E    F+ K++   H NH Y++D    L ++ G+ ++  E  S         +   + K++LC  ++ + N+I+PG +R +G+++YEL     I   +
Sbjct:   31 YKIIRNDSVGRYMVATRDIKPGETVLMEYPLTFGPGNPNEPICLGCYTPVLKNQHTECDGCGFPMCSKECSQILEHKDFECAEMHNMNFRLDSQNTLKWNGSQESVYNAISLMRALVLKKRDPARWNLIWMHMSHDEARQKDTFWQKKDAKTLEHIKAMMKISPE--DYDTIKIILGIFLVNDFEICIPLEGSDEKSSLIRGIFALASMPNHSCVSNCYHNFTCREEGFKMTMKAVVDIKEGDEITHSYTEPLDPIMRRQSLLKIGKFFQCNCIRCRDPTEMSTYSSALICSKC---KKGNVISKNCKNINSDWECDSCDLTLSPDSVEQVNSKAKSEIEEMDK-NPDVETHEQFLNKYATIFHPNHVYMIDRSYVLGKMYGR-MEGYEPDS-------LSDDQFMRKKELCERVLKVLNVITPGQTRKKGMMMYELHLPFVIMGNR 463          

Query:    9 KISCAFCNGDANQRCTGCHVTFYCSR-EHQKQHW--KKHKTNCC-AFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIR-CTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQ--LEAHAEKRKLNGR--VDKDQIILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPV----TPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQE---VRRYLIECIQIFSFESE 514
            K  C +C   A   CT C +  +CS   H+  H+  KK +T+ C  F +  +S +GRH+VATRD++  E++L E+PL+I P   +   CL CFK +D S   C +C +P CS  C     H  EC+     G         +   N  Y  I TLR + L++S P+ +  +M+  L+ +++ ++         ++ ++K I+     +A     D +  L G++  N  ++ +           LYL  S + H+CV N       D  +++RA+V+I KG+ I   Y  P      R+  +    +F C C RC DP E G+   +L C SC +     +  INPL+  S ++C  C  E   +YV  V+ S+GE L +    +P +    +      LH NH+  ++ +L +  LIG N+ T             R      K++ C  ++ + +++ PG ++ R  IL EL  T        F A          I+QE    + YL     IFS +S+
Sbjct:    4 KAECFYCGNPATASCTTCELVSFCSEPSHKALHYGHKKDETSFCFPFAVKRNSQLGRHLVATRDIKALEVILEESPLVIGPYISSNNQCLECFKTLDTSPHSCISCNYPFCSQECSQGPWHKIECSAFQKYGHK------RDENDNDFYSIITTLRLLSLQESKPEFWNTIMKDMLDHNSDIQEYTPEKWTSYEETVVKKIQSLTKGNADT---DTLTRLIGVIDTNGADLNLPHDGKHGKGTGLYLIYSNLNHSCVCNTKTINFQDRRIEMRASVNISKGEQICNQYVRPNKCTLARRTTIKNKWYFDCCCKRCADPTECGSYLGALLCSSCKS----VVLPINPLETESNWACKGCSKEYDVEYVMGVLISVGESLEEATPYDPNSYEKILYDTQDLLHPNHYLRIEAELKVAALIG-NIPTSSFSKGMPRPAVER------KRQCCFHILEVLSLVDPGFNQWRVQILSELTKTKLYLVNIDFNAGLADKVEVFKILQEQQVFQYYLAYNQSIFSRQSK 505          

Query:  151 IYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQIILKMIRRFFNISASLI--------------SDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLE-KGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLR---GVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFE-SECIQEGRLASVARLKLAEVEDQLSSF 539
            +Y+AIA LR + L++++P  F K+M LE+H E+RK   + D      + I +  ++    +              SDD +  + GIL  N+ E+ +  + + ALY  + L+EH+C  N    FD    + +RA  +I+ G+H+   Y+  +WG   R++HL  +KFF C C RC+DP E G+N S+L       +    L    PL+ + P++        +AD V + +  IG EL  L+  G  +  + FI K+   LH NH++L+  K +L Q++G++      + + + D   + +D      LC ++I +  +I P I RL+    V LYEL   L    ++K+    +  + F+  +QE R Y+ + + +   E +E + EG    V RL + +   QL  F
Sbjct:   78 LYDAIAPLRILLLQKTSPKKFGKIMSLESHFEERK---KADPPTAWKRTIEKVIDVMKKTLGIMVFEVLYKQFDFSDDTIQRINGILETNAIEIRLAASEIQALYELTCLLEHSCCPNIRMTFDDKYHVTVRAGRNIKAGEHLCFMYTHSLWGTMARREHLYLNKFFWCKCLRCEDPSEYGSNISTL------VREEKELLQRKPLEPNCPWTSRDGSVVITADEVMSEMSIIGAELALLQLNGTVDEYIQFIDKYEVFLHSNHYHLLTAKHSLLQMLGRS------EGHLIQDLPEKMED------LCRQVIDVCKLIDPSIVRLQIYVAVALYELHLPLLQILKRKWENGGLPTEEFRKELQEPRDYITQALDLLKDEVNENLPEG----VMRLTVKDTLSQLDLF 460          

Query:   92 ICLACFKPVDGSIR--------CTTCGWPMCSDLCIGSSN-HVPEC-TLNNS-RGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQIILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTP--VLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFS--CDHCHCEESADYVNAVIRSIGEELVQLEKG--NPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLD-TVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTL---AIYARKKFAAKEITLDHFKNIIQ 496
            +CL C+    GSI+        C+ CG P+C        N H PEC  L++S RGK     +  N   + ++E +  LRC++L+   P+ +   + L +H  +R+ +    +     +   R   I    I  +EVL++ GIL  NS E+P+  +P  + A+Y    L EHNC+    + F++D SL +RA+V ++ GDHI ITY+D +W    R+ HL+ SK F CIC RC+DP E G+   +L C  C     G +   NPL+  +  S  C  C       +       + + +  +E G  NPE C  FI  +S+ L+  H +++DVK  L  L+G +    + D SN ++          +K+ +   L+ +A  I PGISRLRG  LYEL  T    A+  + +   +E  L  F+ I++
Sbjct:  440 VCLNCY----GSIQDENEDISVCSRCGLPLCGQCDESELNLHKPECHALSSSKRGKRTSLALLDNV--SLLFEVVLVLRCLHLRDI-PENWSHFLGLTSHVGERRDSELEARALEASEXXIRDIGIE---IPREEVLNICGILDTNSFEIPLPSSPGTIQAIYKIGCLPEHNCIPTGHRCFESDLSLVLRASVDLKAGDHITITYTDSLWPTMERRTHLLYSKHFSCICERCRDPTEKGSFIGALNCLKC---GVGRILPENPLEDKNETSWICIDCGYVSPQGFAEDTYNQVAQVIQGMESGEINPEQCNRFITLYSKILNSQHAHMLDVKHTLLHLLGHHEGYLLGDLSNYLLQ---------LKEDIARCLLQVAEKILPGISRLRGTTLYELYLTYQQRALNWKGEGKKQEEILAAFRVIMK 843          

Query:   50 AFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIRCTT--CGWPMCSDLCI---GSSNHVPECTLNNSRGKPIPDEVGSNSVP-NPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEK-RKLNGRVDKDQIILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTP------TPVL-----ALYLNSSLIEHNCVSNASK----HFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIG--EELVQLEKGNPEACL-----TFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLS 537
            +++I   S  GR++VA++D+ PGE +L+E  L  +P   T P+CL C+  +     C    CGWP+CS+ C+    +S+HV EC+L  S  +  PD    N +   P Y+ +  +R +  K S+   +    +L +H E  +K+ G ++    ++K ++  F  +    +D+E+L + GI + N   V V         PVL      LY  +SL+ H+C  N  +      D    L+++A   I KG+ I  TY D       R++ L ESK F C C RC +  + G   S L CP C      Y+     L     + C  C  E   +    +++  G  EE+++    +PE+C      +FI    + LH ++   + +  +L    G+    +      VM     EK L  K ++   ++        GIS  +G+I YEL   + +  + +  A  +  D  K+I Q+   +L   +    +E+    EG++ + A L L  ++  +S
Sbjct:   28 SYRIKFDSKEGRYLVASKDIEPGEDILTEEALFWSPRYSTRPLCLVCYGYLYNKESCYICECGWPLCSEECLXXAKTSDHVLECSLYTSHSQLRPDVHAFNFLGVEPSYDVVGPVRLLSKKGSSK--WYMTWKLMSHLEDWKKIPGWIEAHHSVMKELKALFTET----TDEEILTIFGIFYTNDFGVRVNAGVDGNGNPVLCPKIRQLYTLTSLLSHDCEPNTFRVINSKVDKKFRLEVKAKRRISKGEKITGTYVDVFAPTIVRKKVLKESKLFDCTCKRCSEAQD-GVGGSDLVCPKC----QNYVVCQKDLT----YICSGCK-EPYPEGPKKLLKYYGDLEEILE----DPESCTVQAYESFISTRKKELHPHNLIFIRLMYSLSGFYGR----LSGYEXPVM----TEKMLRRKWEIGEVVMKALETFDLGISSYKGMIDYELHMPMIMLTKMELDAGYVEYDKAKDIFQKALTHLKASLSHLQYENPMSFEGQIYAGASLSLVPLDSFIS 516          

Query:   51 FKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPI--CLACFK--PVDGSIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIAT-LRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQIILKMIRRFFNI-SASLISDDEVLDLQGILFVNSHEVPVTP----TPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRC 325
            + I SS+V GR V ATRD+  GEL+  E  L+  P A    +  C+ C +  P  G +    C  P+C + C  S  H  EC  +  R +P   +     V NP+   I T +R  +L +    + + +      A +R+          I++  + F N  +   +  D++  + G+L  N+ E P       T +  L+  ++++ H C  NAS +F+      +RAA  I KG  I  TY+  +WGN  R   L  +K F C C RC D  E GT  S+L C
Sbjct:   57 WTISSSTVAGRGVFATRDIAAGELIFQERALVTGPTARKGQLSSCICCHETLPQTGFLCRHRCTLPVC-ETCSDSEEHQAECE-HFRRWQPKDVDAEQEQV-NPMSLRILTAVRVFHLGKEQRHLVDAMQANAERAYRRE----------IIQAAQCFRNFPTTDRVFMDQLFRIVGVLNTNAFEAPCRSGGHETLLRGLFPLTAIMNHECTPNASHYFENGRLAVVRAARDIPKGGEITTTYTKILWGNLTRNIFLKMTKHFACDCVRCHDNTENGTYLSALFC 328          

Query:   50 AFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAY---TVPICLACFKPVDGSIRCTT-----CGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQIILKMIRRFFNISASLISDDEVLD-------------LQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRC 325
            ++++  S + GR + ATR++  GE +  E+ LL+ P A+    +  C  C++ + GS          CG P+CS+ C  S+ H  EC L   + KP+     S  +       ++ +RC +L +++  +   +              + + D+  ++ ++R  +       + ++LD              +    V+ HEV V      AL+  + L+ H C  NA+ HF+   ++ + A   I  G  I ++Y+  +W    R+  L  +K F C C RCQDP E GT  S+L C
Sbjct:   43 SWRVADSPISGRGIFATREIAAGEELFREHTLLVGPTAHRSMNLRTCTLCYRLIPGSTDSAALCPAGCGLPVCSE-CRDSTRHDLECKLFR-KWKPLE----SQRIEPRALRILSVVRCFFLDEASRKLLYAM--------------QANMDRYYMQEVQRAADCFEHFPREQDMLDYFYRTICAFNTNAFESRSNVDGHEVLVR-----ALFPLAGLLNHQCTPNAAHHFENGETIVVCATERIPAGAEITMSYAKLLWSTLARKIFLGMTKHFICKCVRCQDPTENGTYLSALFC 314          

Query:  214 DEVLDLQGILFVNSHEVPV----------TPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTN 319
            D  + +  IL++N+  + +          +P   + LYL +S I H+C  NA  HF  D ++ +     I  GD I I+Y+D      +R+  L E+  F C C +C + L +  N
Sbjct:  227 DWFVRVMQILYLNTIGIDIDPNQQSTKMSSPESGIGLYLLTSFINHDCDPNAFIHFPDDHTMHLSPLKPINPGDEITISYTDTTKDLVDRRSQLFENYGFNCECKKCLNDLLIKRN 342          

Query:   34 REHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKD-QIILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSSFDTK 542
            R+HQKQHWK+HK++CCA+KIC S  +GR++VATRDL+PGE+V+SE PL++ PMA TVP+CLAC+KP DG   C  CGWPMC+  C  S  H PECTL  SRG P+       + P PIYE +  LR +YLKQS+P  ++K  +LEAH E R+ NGR DKD   ++++IR F  I  ++ +  E+LD+ G+L VN+HE+P+T  PV ALY N SL+EH+C++NASKHFD D  + +RAAV+I+KG+HI+I YSDPMWG A+RQ HL E+K+F C C RCQDP E+GT FSS+RCP C  +  GYL S NP    + ++C  C   +   +V+AV +SIGEELV LEKGN EAC  FIKKHSQNLH NH+YL D+KLALCQ+IG+   +   Q + V  F   EK+L+ KQK+ +EL+ +AN ISPGISRLRGVILYELQ+TLA YAR+KF+A EI+ +H +NI++EV++YL+ECIQIFSFE  C+QEGRLA++ARL L E+E  L S   K
Sbjct:    3 RDHQKQHWKRHKSSCCAYKICMSPELGRYLVATRDLKPGEMVISETPLVLGPMAVTVPVCLACYKPADGKFSCLKCGWPMCNPGCAKSPVHEPECTLTASRGSPLQMPSNCYNKPYPIYEVVTILRSLYLKQSSPSKWKKFKELEAHEEGRRRNGRYDKDLSTMVRVIREFLRIPETVFTQQEILDVCGVLTVNAHELPITTVPVQALYANISLLEHSCINNASKHFDGDFRVVVRAAVNIKKGEHISINYSDPMWGTASRQLHLAETKYFNCQCVRCQDPTEMGTMFSSIRCPQCTVEQGGYLVSENPTGGPANWTCIACTKVQPHSFVDAVTQSIGEELVMLEKGNIEACQAFIKKHSQNLHPNHYYLQDIKLALCQMIGQ---SATGQGHEV--FNLSEKELVYKQKIGLELLEVANRISPGISRLRGVILYELQATLAAYARRKFSAGEISSEHMRNIMKEVKKYLVECIQIFSFEPPCLQEGRLATIARLDLLELETFLDSLQNK 507          

Query:    2 SELAEIEKISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIRCTTCGWPMCSDL-C-IGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQII-LKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPV----TPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSSFD 540
            +E+  +E+I   FC  +A QRC+GC   FYCSREHQK  WKKH++NC A+++  +  +GR ++A RDL+ G+++L E PL++ P      +CL C+  VDG  +C+ CGWP C  + C    S+H  EC L  S G+PI   VG  S+P   Y+++  LRC+ LK  NP  +E+L+QLE+H  +R+  G  D DQ   +++IR    +    + ++ +L L GIL VNS E P     +P  ++A+Y  +SL+EH+CV+NA K F  +G + IRAAV I KGD IA+ Y++P+WG  NRQ+HL ++KFFQC+C RC+DP EL T  S L C  CP Q+ G L   NP D  S + C  C   + A+YV  +I S+G+E+V L+KG+ + C  F++K S+ LH NHFYL DVK+ALCQ+ G     +E QS   M+  T    LI K+ L +EL+ +A+ +SPG++RLR ++LYELQ+ L++  RK    + I+ +  +  ++ VR+ L E   IFS+E E   EG+LA ++  +L +VE  L + D
Sbjct:    4 TEMTGLEEIGKCFCGKEALQRCSGCQSVFYCSREHQKADWKKHRSNCRAYRVERTLNVGRRLIACRDLKAGDVILQEKPLVMGPKYTAGQVCLGCYSSVDGRTKCSQCGWPTCGRVECHTNDSDHAVECGLIASGGRPI---VG--SLPVQAYQSVMVLRCLALKDQNPGRWEELLQLESHVHERRQRGLEDVDQATSVRLIRETLGLD---VPEELILQLCGILMVNSFEQPPLKANSPQGLVAVYSTASLLEHDCVANAIKTFTNNGDIVIRAAVPISKGDKIALCYTEPLWGTVNRQRHLSQTKFFQCVCERCKDPTELDTFISGLYCQKCPQQS-GILLIENPTDDASDWKCRQCGTRQPANYVAEIIESVGKEIVALKKGSLKDCEVFLRKFSKILHPNHFYLTDVKMALCQMYGH----LEGQSLIEMNDDT----LIAKEALALELLKVADAVSPGLTRLRAILLYELQAVLSVRCRKLCVTQSISKEELQANVKVVRKMLQESSTIFSWEPEETDEGQLAVISAKELRDVELFLKTLD 532          

Query:   14 FCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSIRCTTCGWPMCS--DLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQII-LKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPV----TPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSSFD 540
            FC  +A+QRC+GC   FYCSR+HQK  WKKH+++C A++I  +  +GRH++A RDL+ G+++L E P+++ P      ICL C+  VDG  RC+ CGWPMC   D     S+H  EC +  S G+PI   VGS  +P   Y+++  LRC+ L+  NP+ +++LMQLEAH ++R+  G  D DQ   ++ IR    +    I ++ +L L GIL VNS E P     +   ++A+Y  +SL+EH+CV+NA K F   G + IRAAV I KG+ IA+ Y++P+WG  NRQ+HL ++KFFQC+C RC+DP EL T  S   C  CP Q+ G L + NPLD  S + C  C   + A+Y   +I S+G+E+V L+KG+   C  F++K S+ LH NHFYL DVK+ALCQ+ G     +E QS   M+  T    L  K+ L +EL+ +A+ +SPG++RLR ++LYELQ+ L++  RK    + I+ +  +  ++ VR+ L E   IFS+E E   EGRLA ++  +L +VE  L + D
Sbjct:    7 FCGKEAHQRCSGCQAVFYCSRDHQKSDWKKHRSHCKAYRIEQTLTVGRHLIACRDLKAGDVILQEKPIVMGPKHTAGQICLGCYSGVDGRTRCSQCGWPMCGRDDCHAHESDHAAECGVMASGGRPI---VGS--LPVQAYQSVMVLRCLALRDQNPERWDELMQLEAHVQERRQKGMEDVDQATAVRFIRETLGLQ---IPEELILQLCGILMVNSFEQPPMKGNSQHGLVAVYSTASLLEHDCVANAIKTFTNKGDIVIRAAVPIPKGEKIALCYTEPLWGTMNRQRHLSQTKFFQCVCERCKDPTELDTFTSGFYCQKCPQQSAGILLTENPLDDASDWICRQCGARQPANYAAEIIESVGKEIVALKKGSVRDCEGFLRKFSKVLHPNHFYLTDVKMALCQMYGH----LEGQSLIEMNDDT----LNAKEALALELLKVADAVSPGMTRLRAILLYELQAVLSVRCRKLCLTQSISKEELQANVKVVRKMLQESSTIFSWEPEETDEGRLAIISSKELKDVELFLKTLD 524          

Query:    1 MSELAEIEKISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDG--SIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQI-ILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPS--CPAQANGYLSSINPLDIH-SPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKF--AAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVE 533
            MSE+A+     CA C   A Q+C+GCH+ +YCS+EHQK +WK HK +C  FKI +   +GRH++ATR+L+PG+++L E P++  P   T+P+CL C K ++   S  C  CGWPMCS++C  S +H+PEC+   +RG  +   +    +PNP Y+ I  LRC++ KQ   +V++K+  LE+H E RK   + ++++I ++  I+RFF + +    D+++L + GI+ VN+HEVP+T  P +A++  +S+ EH+C +N SK F  +G + I A V I+KG+H++I Y+DP+WG ANR+ HL ++KFF C C+RCQD  E GTNFS+L+CP   C   A       + L++    + C  C+ E  A  V  +++  G  L  + KGN  AC  FI    + LH NH+YL DVK AL QL+G+               +  ++DL +K  +C +L  +AN I+P  +R++G++L+EL + +    R++     +E   D+    + + ++YL++ I+    ESE + EG++   AR  L +++
Sbjct:    1 MSEVAK-----CAVCQKPAQQKCSGCHLVYYCSKEHQKDNWKLHKIDCKPFKISNDPNVGRHLIATRNLKPGDVILKEPPIVWGPSQVTIPVCLGCGKGLNAKTSKPCQKCGWPMCSEICQNSPSHIPECSYTVNRGDKV--NISVFDIPNPSYQCITVLRCLHSKQFLSNVWKKIDALESHCEARKGTDKYEQEKITVVAFIKRFFKLDS--FEDEDILRICGIIMVNAHEVPLTDPPYVAIFNTTSMFEHSCHANCSKTFTANGHVLITAGVDIKKGEHLSICYTDPLWGTANRRHHLQQTKFFWCSCSRCQDVTEFGTNFSALKCPKKDCKGYALPKTFKEDNLELSDKSWFCTTCNYEVGAGEVGGILQDCGTNLSGIRKGNSNACKVFISNSLKFLHPNHYYLTDVKFALSQLLGQEFHGGLP--------KISDEDLQLKIDICRQLTELANKIAPAENRIKGLLLFELHAAIMELGRRRGNSGTEESGPDYLYTKLIDSKKYLVQSIEALKNESEVMPEGQICIQARRNLKDID 524          

Query:    8 EKISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPV--DGSIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQIIL-KMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHS-----PFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSS 538
            E+  C  C   A Q+C GCH+ +YCS+EHQK  WK+HK  C  FK+C   ++GR+VVATRD++ GE+VL E  L+  P   +VP+CL C   +       CT CGWPMCS+ C  +  H+PEC     RG  +   V +  + +PIY+ I  LRC+Y KQ  PDV++KL +LE+H E+RK + + + ++I + + I +FF +  +  ++DE++ + GIL VN HE+P++  P + L+ + S+ EHNC  N  K F   G + I + + I KG H++I Y+DP+WG  NR+ HL ++KFF C C RC D  E GTNFS+++C +  ++ NGYL   + +D         + C  C    +A  +  ++   G++L  LEKGN  +C  FI  +   LH NH+Y+ DVK+AL Q++G+  +      N   D      DL++K  LC  L ++  I+ PG SR+RG++L+EL + +A   R+K     +  D     + E +R L+E   +  FE +C+ EG+L   A++ L ++E  L +
Sbjct:    3 EESKCDICAKPALQKCGGCHIVYYCSKEHQKNGWKQHKRQCKPFKVCQDDILGRYVVATRDIKAGEIVLQEPALIWGPSQTSVPVCLGCGNAITEKNCKPCTKCGWPMCSETCEKAPAHIPECRYTVLRGDKV--TVKNFGIIHPIYQCITVLRCLYQKQFLPDVWKKLEKLESHCEERKRSPKYENERITVGQFILKFFKLENTF-TEDEIMKICGILMVNGHEIPLSDPPHVGLFHSCSMFEHNCRPNCKKSFTNKGEILISSGIKIEKGQHLSICYTDPLWGTPNRRYHLFQTKFFWCKCERCCDVTEFGTNFSTMKCQN--SECNGYLLPKSFIDDEENGKIVDWKCSKCPGFMNAYSIQDIMERAGKDLSLLEKGNSNSCKDFISTYESYLHPNHYYMTDVKIALTQILGQEYEG--GLPNLSDD------DLLLKANLCQGLNNMLKILIPGESRVRGLLLFELHAAIAEIGRRKAL---VDPDELHRTLLESKRILLEAADLLKFEPDCLPEGKLYKQAQMNLLQIEHVLKT 525          

Query:   12 CAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGS--IRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQI-ILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRC--PSCPAQANGYLSSINPLDIHS-----PFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGK----NLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVE 533
            C  C   A+Q+C+GCH  FYCSREHQ+  WKKHK  C  +KIC    +GR ++AT+D+  G++VL E PL+  P   T+P+CL C   +D      C  CGWP+CS  C  S NH+PEC   +SRG  I   + +    +P Y+ +  LRC+Y KQ   + ++K+  L++H  +RKL  + +KD++ I + I  FF +   + +++E+L + GIL VN HEVP+T  P +A+Y  +S++EH C +N ++ F + G++ ++A   I+KGDH++I Y+DP+WG  NR+ HL ESKFF C+C RC DP E GT FS++RC  P+C    +GY+   + LD  +      ++C+ C    ++ +   ++  IG++L ++EKG  +A   FIK + + LH NH+YL+DVKLAL QL+G      L  V D             DL  K +LC  + ++   ++PG SRLRG++L+EL +T+A   R+    +++       ++QE ++ L E   +   E +C+ EG+L   A+  L E++
Sbjct:    7 CQVCQSAASQKCSGCHTVFYCSREHQRADWKKHKKMCKPYKICHDEALGRFLIATKDISVGDIVLQEPPLIRGPSQVTMPVCLGCGNAIDEKNFKPCAKCGWPVCSSTCEKSPNHIPECQYTSSRGSKI--TISTFGSIHPSYQCVTVLRCLYQKQFLSETWKKIDLLQSHCAERKLTSKYEKDRVSIAQFILNFFKLR-QVFTEEEILRVCGILMVNGHEVPLTNPPHVAIYEIASMLEHKCNANCNRTFTSQGAVLVKAGTAIKKGDHLSICYTDPLWGTLNRRHHLYESKFFWCLCERCADPTEFGTYFSAIRCQKPNC----SGYILPSSFLDQSANGKLPNWTCNKCESSCNSYHAQEILDRIGQDLHEMEKGTTKAAKDFIKTYEKYLHSNHYYLVDVKLALSQLMGHEDAFGLPAVGDD------------DLQYKARLCQGIANLVKTLAPGESRLRGLLLFELHATVAELGRRNADPQQLPA-----VLQESKKLLQESCDLLRHEPDCLPEGKLYIQAQKNLKEID 518          

Query:    8 EKISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLAC--FKPVDGSIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQI-ILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHS-----PFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGK---NLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVE 533
            E+ +CA C   A  +C GCH  +YCS+EHQK  WK HK  C  FKI S+ ++GR + AT+D++PGE+VL ENPL+  P   TVP+CL C  F     S  CT CGWP+CSD+C  + +H+PEC     RG  +   + +  + +P Y+ I  LR +Y KQ  P+V++KL  LE+H E+RK   + ++++I I + IRRFF +  +  ++DE++ + GI+ VNSHEVP+T  P +A+Y N+SL+EHNC +N SK F   G + I+A  HI+KGD+++I Y+DP+WG  +R+ HL ESKFF C C+RC D  E GT FS+LRC    +   G+L     +D  +      ++C+ C    S+     ++  IG++L ++ KG+   C +FI+ + + LH NH+YL DVKLAL Q+IG+    L  V D+            DL  K  +   L+ + + ++PG  R++G++LYEL + ++   R+   +     D     + E +  L E  ++   E + +QEG++  +    L E++
Sbjct:    3 EETNCAVCQKPAGHKCGGCHNVYYCSKEHQKSGWKSHKKQCRPFKITSNDILGRFLKATKDIKPGEIVLQENPLIWGPSQTTVPVCLGCCKFITTKNSRPCTKCGWPVCSDVCEKAPSHIPECRYTVLRGDKV--SITNFGIVHPTYQCITVLRLLYQKQFLPEVWKKLELLESHCEQRKGTQKYEQERISIAQFIRRFFKLENTF-TEDEIMRVCGIVMVNSHEVPLTEPPHIAIYENTSLLEHNCSANCSKSFTNKGGVLIKAGRHIKKGDNLSICYTDPLWGTPSRRHHLRESKFFWCSCSRCVDTTEFGTYFSALRCQD--SGCEGFLLPKTFIDNSTNDKGLDWNCNMCSIVLSSYSAQDLLERIGKDLAEMPKGDERECRSFIRSYEELLHPNHYYLTDVKLALAQMIGQQDEGLPAVPDE------------DLQQKVTITRSLLKLLDTLAPGERRIKGLLLYELHAAISELGRRNADS-----DGLYTALLESKEILTESAELLKDEPDELQEGKIYKLTIKNLKEID 517          

Query:    8 EKISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPV--DGSIRCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQI-ILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSI-----NPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVE 533
            E   C  C   A+Q+C  CH  FYC +EHQK  WK HK  C  FK+C   ++GRH+ ATRD++PGE+VL E PL+  P   TVP+CL C   V    S  C  CGWP+C++ C  +  H+PEC     RG  +   V +  V +PIY+ I  LRC+Y KQ  P+V++KL  L++H E+RK   + +++++ I + I RFF + A++ +++E++ + GI+ +NSHEVP+T  P +A+Y ++S+ EHNC +N +K F   G + + A  HI+KGD++ I Y+DP+WG +NR+ HL +SKFF C C RCQD  E GT FSSL+C + P   NGYL        N  +  S ++C  C    SA     ++  IG++L  + KG  + C  FIK +   LH NHFYL DV+LAL Q+IG+     E Q          ++DL +K +LC  L+++   + PG +R+RG++++EL +++A   R+K    ++       ++ E +  L E   +   E + I EG++   A   L E+E
Sbjct:    4 ESGECDICQKPASQKCGACHSVFYCCKEHQKSGWKTHKKVCRPFKVCYDEILGRHLKATRDIKPGEVVLQEPPLIWGPAQVTVPVCLGCGNAVTEKNSRPCFKCGWPVCNETCEKAPGHIPECRYTVLRGDRV--SVKNFGVVHPIYQCITVLRCLYQKQFLPEVWKKLDTLQSHCEERKGTQKYEQEKVTIAQFILRFFKL-ANVFTEEEIMRVCGIVMINSHEVPLTEPPHVAIYESTSMFEHNCSANCTKSFTNKGGVLVAAGTHIKKGDNLCICYTDPLWGTSNRRHHLYQSKFFWCNCKRCQDTTEFGTFFSSLKCQNSP--CNGYLLPKTFIENNNNEKGSDWTCTKCTNVFSAYSAQDLLERIGKDLSDMPKGVSQECKNFIKDYESLLHPNHFYLTDVRLALSQIIGQ-----EGQGGLPA---VSDEDLELKARLCQGLVNLFKTLIPGETRVRGLLMFELHASIAEIGRRKGDPGDL-----HTLLLESKNVLTEAADLLKHEPDFIPEGKIYKQAVSNLKELE 519          

Query:    1 MSELAEIEKISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPVDGSI--RCTTCGWPMCSDLCIGSSNHVPECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQ-IILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYL--SSINPLDIHSP--FSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSSF 539
            MSE ++     CA C   A Q+C GC   FYCS+EHQ   WK H+ +C  FKIC    +GR++ AT+ ++ GE VL E PL+  P+ +T P+CL C K ++      C  CGWP+CS+ C  SSNH+PEC+   + GK I  +V     P+P Y+ I  LRC+Y+KQ+ PD++EKL +L++H E+RK   + ++D+  +   +R FF +   + +D+E+L   GI+ VN HEVP+   P +A+Y  +S+ EH+C +N  K F   G + I A V I KGDH+ I Y+DP+WG  NR+ HL ESKFF C+C RC DP E GT  S LRC     + +G L   +    ++ +P  ++C+ C+ +   +    ++  +G +L  ++K +  A   F++ +S  L  NHFYL DV+LAL ++IG  L   E+  + V D      DL +K +LC +L S+  I++P  +RL G IL+E  + +A   R++    E     F + +QE +R L E   +   E E I+EG+L   A+  L  +E  L++F
Sbjct:    1 MSEFSK-----CAVCQKSAEQKCGGCFSVFYCSKEHQITDWKTHRKDCFPFKICEDPHLGRYLKATKPIKKGEKVLQELPLVWGPLQHTKPVCLGCGKGLNSQTCRPCEKCGWPVCSERCEKSSNHIPECSFTTAVGKRITIDV--FDAPHPSYQCITPLRCLYIKQNMPDIWEKLDRLKSHCEERKKTEKYEQDKYFVANFLRSFFQLE-EVCTDEEILRFCGIVTVNGHEVPLKKPPFVAVYEKTSMFEHSCKANCCKTFTAKGEVLITAGVPIEKGDHLTICYTDPLWGTPNRRYHLSESKFFWCVCPRCSDPTEFGTYLSCLRCKL--KECDGILIPETFISENVTTPIIWTCNACNMQIDDEEAQNIVEHVGRDLQAMDKDSTSASKKFLEYYSNILPTNHFYLTDVRLALIEIIGMEL---EEGLSGVSD-----DDLHLKLQLCKQLSSLVQILAPAENRLMGTILFEQHAAIAEIGRRRTNFGEEGQGDFYSTLQEAKRILTEAATLLKNEPEEIREGKLYKQAKFALDNMEIILANF 528          

Query:    1 MSELAEIEKISCAFCNGDANQRCTGCHVTFYCSREHQKQHWKKHKTNCCAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAPMAYTVPICLACFKPV--DGSIRCTTCGWPMCSDLCIGSSNHVPECTLNN-SRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQI-ILKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPL----DIHSP-FSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTFIKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGISRLRGVILYELQSTLAIYARKKFAAKEITLDHFKNIIQEVRRYLIECIQIFSFESECIQEGRLASVARLKLAEVEDQLSSF 539
            M     +   +CA C   ANQRC GCHV +YC R+HQ+  WK H++ C  FK+  +  +GRH++ATRD++ GE++L E PL+  P   T P+CL C++ +    +  C  CGWPMCS+ C  +  H  EC +    +G  +   V +   P+PIY+ + TLRC+YL+ S+P  +E+L  LE+H E+RK   R + D++ + + +R FF++       +E+L + GIL VN HEVPVT  P +A+Y  +SL+EH+C  N SK F  DG L I A   I KG H++I Y+D +WG ANR+ HL E+KFF C C RC DP E GT FS++RC S     +GYL   N L    D+ +  + C  C   E+A  V +V+  +G  L  ++KG+P  C  F+ + S  LH NH+YL DV+LAL QL G        Q++ V      ++DL  K  LC +++ + N + P   R+RGV+++EL + +A  AR+     ++     ++ + E +R L E   + S E E + EG++A  AR  L ++   L + 
Sbjct:    1 MDRQGAMGPKTCAVCTEPANQRCGGCHVIYYCCRDHQRLDWKGHRSRCKPFKVADNKALGRHLIATRDIKVGEVILDEQPLVAGPSQVTPPVCLGCYRILTEQSACACLDCGWPMCSEDCARTPAHRAECDITKLKKGSKV--TVRNFLQPHPIYQCVTTLRCLYLRDSDPVKWERLQSLESHCEERKKTRRYEDDRVTVAQFLRHFFHLQD--FEQEEILRVCGILQVNGHEVPVTDPPHVAVYDQASLLEHSCRPNCSKSFTPDGGLIIHALEPILKGQHLSICYTDALWGTANRRHHLAETKFFWCRCVRCADPTEFGTYFSAVRCLS--KTCDGYLVPENSLLEDSDLGTTIWRCGRCSVSETAPRVLSVLERVGSALSSMQKGDPRVCEHFLAQFSPELHPNHYYLTDVRLALAQLYG--------QTSDVGLVGISDQDLSEKASLCRQVLELMNTLVPAEHRVRGVLMFELHAAVAEVARRASNRGQLDPMALRDSLLESKRLLTEASFLLSHEPETLPEGKIALQARKNLTDLNTLLQNI 534