BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000003893 (supercontig:LSalAtl2s:LSalAtl2s210:437224:444319:1 gene:EMLSAG00000003893 transcript:EMLSAT00000003893 description:"maker-LSalAtl2s210-snap-gene-4.17")

HSP 1 Score: 952.199 bits (2460), Expect = 0.000e+0
Identity = 493/1113 (44.29%), Postives = 666/1113 (59.84%), Query Frame = 0

Query:  533 AEKARQFDLASPASFEEGCMLWARVGGAPYWPCAVINDP-------------------------------DLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEFLLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSAVSEEEFPAKRGRFDMAEELIQAIAPETLEAHRRKLKTGFKLFQLANLERIRRDSADHTEAE----RKLGKMWAGVSGMERKFYQEQASNLGQSDPVDDSQSSLQEDDDYVILDSEDEAFNDEASVSSSVKSSKFVEPRQEKENRQPSEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDD-----WKCAECASGNHACQICK---------GYGQDVS-----------RCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFV-CPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTK--------KSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHI-STPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGN---NSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKN---VNGNGLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDTAVENHAELGNICDEH-EDDFEDLLNFY-NKVGGISKLVPHPNVPM 1566
            AE A+  +  +   ++ G ++WAR+G + +WP  V  DP                               + GI+ R   +RG+ + E+HV FFG  I+RAWV +  I  + GIE+F    +  +   KGK         +  + K     W+ AV+ A+ T  L+  ER+ ++            Q   + S  +   SRKRK  ++  +     S +  P K+ + +   ELI +I    LE  ++KLK+   LF LAN +R   +  D   +E    R L  +W  ++  ERKFY+++   L      +  + SL        L  ++     E        S     P   K  +  +EMIG++K E  CI+CE+V+    DLI C+G CG+S+H  C+   + +  D     WKC +C      C +CK         G  +D S           +C+  GC R +H  CL  + LWPQ+     + + CP HMCHTCASDN   P+MKY+++LLKC+ CPT+YHSGDYCV AGT+QITS  I+CPKH +    T         K   S H+N +WCF+CS GGSLICC+ CPASFH+ECL++ + P+G +YC +C  GRMPLY E+VWVKLG YRWWPA V+HPSE+P N+  L H+ G+FP++FCGS EY W++ GR FLYE GD DK+P     + K +  +F++GL EA E+   Y   K  REA +  K       KPP+Y KIKTNRP+GD PVYT+ +S+ + C+CD  + +PC  DSDC+NR LMVEC+ S+CPAK++C N +F +R YP L V  T++RGWGL V + +KKG FIIEYVG+LIT +EF+ RL+ S   KE+ NFYYMTMD++RMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVG+F  +DI  N+ELTFNY+FEA+GEVK  CLCGA NCSG+IG+KP   KN   V     + KK   K    K WED+CFRC   G++LMCD+KTCPKVYHL CL R+KMP  +WFCPWHHCV CGK AV+YC+HCPNAYCK H+  +  H+ L NIC+EH E+D   L+N+Y ++ G + K++  P  PM
Sbjct:  440 AESAK-LEFLTHCEYKPGDLVWARIGDSNFWPSVVTIDPQSIRENLGITDNVVKLEESIPMEVEDEFAKSNQGIFNRFETKRGFKYVEFHVDFFG-FIRRAWVSARQIFPFTGIEDFEKYLQIYQKVYKGK---------FNNFSKSNNEKWNVAVKDAQTTCHLTGPERIKRI------------QELQTNSYQVFKFSRKRKLKSNCSSENEPESIK--PTKKRKVEAPSELIXSIPRNVLENEKKKLKSAVNLFCLANKDRXIEEEEDPKMSEKDINRILMTLWKNLAPTERKFYRQELGRLSGVVSNEKLKKSLS-------LRQKEMTKKKEIVKQLKQPSPSPSTPSTPKVPKAQAEMIGIFKNERFCILCEDVSMKPGDLITCQGTCGNSYHIKCIDNSSISSTDSPTTSWKCKDCVDNIQRCXLCKKGSSXSDKEGDDKDKSKDNNVIEHRLMKCTHKGCIRLYHPSCLTSSSLWPQTIFKPKQILTCPAHMCHTCASDNISNPVMKYSAKLLKCVXCPTSYHSGDYCVAAGTIQITSXAIICPKHTSNNNFTNSKSINNVSKKGSSKHINVSWCFICSSGGSLICCDFCPASFHSECLNLPNLPEGKYYCQTCCNGRMPLYREVVWVKLGAYRWWPAAVVHPSELPENVNRLNHQTGDFPVKFCGSNEYSWVSHGRTFLYEKGDSDKMPEGSFCSKKSITESFRKGLVEAAEIHLHYLGAKTKREAKNVQK-------KPPLYQKIKTNRPYGDVPVYTDASSEVQVCNCDHKSENPCNEDSDCINRMLMVECQMSTCPAKDRCRNMQFQRRSYPPLRVAYTESRGWGLFVDKPIKKGRFIIEYVGDLITMEEFRNRLRKSQAAKEDENFYYMTMDSNRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGIFTLKDIPANTELTFNYKFEAVGEVKKTCLCGAVNCSGYIGKKPASLKNNGEVTPRSSQSKKKVKKFKLIKAWEDVCFRCYKGGEVLMCDHKTCPKVYHLACLSRDKMPHGRWFCPWHHCVECGKSAVSYCVHCPNAYCKNHEATLVEHSLLKNICNEHDEEDINSLVNYYKSEDGSVRKMLTSPAAPM 1513          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000006229 (supercontig:LSalAtl2s:LSalAtl2s33:761982:771430:1 gene:EMLSAG00000006229 transcript:EMLSAT00000006229 description:"maker-LSalAtl2s33-augustus-gene-7.11")

HSP 1 Score: 157.147 bits (396), Expect = 3.225e-38
Identity = 86/228 (37.72%), Postives = 128/228 (56.14%), Query Frame = 0

Query: 1211 YTKIKTNRPFGDCPVYTEDASDKTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTK-RIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEAL----GEVKTKCLCGAHNCSGFIGEKPKDGKNVN 1433
            + KIK N  + D        ++  C C+   +S CG   DC+NR    EC P  CP K++C N    + RI   +   +T  +GWG+    ++KK  FI+EYVGE+++  EF+ R+      + +S+ Y + +++  +ID    G   RF+NHSC+PNCE QKW+VNG  R+ LFA  DIK N ELT++Y F       G++   C CG+ NC G IG + +  KN+N
Sbjct: 1714 HKKIKNNV-YVDIKQPQSKMTNHPCHCEV--TSNCG--DDCINRMTYTECDPRFCPTKDQCTNNAIQRHRIPIGVERFMTAEKGWGIRTKCEIKKSTFILEYVGEIVSEKEFKHRMLNEY--ENDSHHYCLHLESGIVIDGHRMGGECRFVNHSCEPNCEMQKWSVNGLNRMTLFALRDIKPNEELTYDYNFSLFNPHEGQI---CRCGSDNCRGVIGGRGQIVKNIN 1931          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000010456 (supercontig:LSalAtl2s:LSalAtl2s693:2320:8904:-1 gene:EMLSAG00000010456 transcript:EMLSAT00000010456 description:"maker-LSalAtl2s693-augustus-gene-0.11")

HSP 1 Score: 152.525 bits (384), Expect = 7.408e-37
Identity = 75/201 (37.31%), Postives = 111/201 (55.22%), Query Frame = 0

Query: 1235 CDCDTD------NSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDG 1429
            CDC         N   CG   +CLNR L +EC    C   + C N++F       + V  T  +G+G+    ++    FI+EYVGE +   +F+ R +    +++  +FY+M +     IDAG KGNI+RF+NHSC PN ETQKW  +G  R+G F K  +    E+TF+Y++E  G+   +CLC A NC G++G +P  G
Sbjct:  696 CDCSLTKEEISLNKRGCG--ENCLNRLLKIECS-KLCSLGKLCGNKKFQSSDNAPVEVFKTNCKGFGIXATANIPGDTFIMEYVGEXLDAKQFRKRAK-RYAKEDVRHFYFMALSTENCIDAGSKGNISRFINHSCSPNSETQKWMXDGGLRIGFFTKRKVSSGEEITFDYKYERYGQEAQECLCEAENCRGWLGGEPLKG 892          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000009522 (supercontig:LSalAtl2s:LSalAtl2s612:295113:313925:1 gene:EMLSAG00000009522 transcript:EMLSAT00000009522 description:"maker-LSalAtl2s612-snap-gene-3.17")

HSP 1 Score: 99.3673 bits (246), Expect = 1.161e-20
Identity = 45/131 (34.35%), Postives = 75/131 (57.25%), Query Frame = 0

Query: 1292 RGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFI 1422
            +G GL    D++K   IIEY+GE+I +D   T ++      +    Y   +D+ R++DA   G +AR++NH CDP+C T+   V+ D  + +FA   I    EL+++Y+F+   + +  CLCGA NC  ++
Sbjct: 4214 QGLGLYAARDLEKHQMIIEYIGEIIRSD--LTDIREKYYESQNRGIYMFRLDDDRVLDATMSGGMARYINHCCDPSCVTETVEVDKDFHIIIFANRRISRGEELSYDYKFDYEDDNRIPCLCGASNCRKWM 4342          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000011680 (supercontig:LSalAtl2s:LSalAtl2s812:116112:121089:1 gene:EMLSAG00000011680 transcript:EMLSAT00000011680 description:"maker-LSalAtl2s812-augustus-gene-1.74")

HSP 1 Score: 93.2041 bits (230), Expect = 4.821e-19
Identity = 61/187 (32.62%), Postives = 95/187 (50.80%), Query Frame = 0

Query: 1232 DKTCDCDTD--NSSP-CGPDSDCLNR----YLMV-ECRPSSC---------PAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQF 1401
            +K C C++D  N  P C   + C  +    +L V EC P  C          +K  C N    + +  +L +  +   GWG+ + +   K +FI EY GE+I+ +E   R    +  K   +F +  ++N  ++DA  KGN  RF NHS +PNC  +   VNGD R+G+FAK  I+   EL F+Y++
Sbjct:  577 EKFCMCNSDCPNRFPGCRCKAACNTKQCPCFLAVRECDPDLCNKCGADQQDTSKITCRNVYVQRGLGKRLLMAPSDVAGWGIFICDFAYKNEFISEYCGEIISQEEADRR--GKVYDKYMCSFLF-NLNNEYVVDATRKGNKIRFANHSINPNCYAKVLKVNGDHRIGIFAKRSIQAGDELFFDYRY 760          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000004581 (supercontig:LSalAtl2s:LSalAtl2s23:123311:134876:1 gene:EMLSAG00000004581 transcript:EMLSAT00000004581 description:"maker-LSalAtl2s23-snap-gene-1.7")

HSP 1 Score: 91.6633 bits (226), Expect = 2.177e-18
Identity = 59/170 (34.71%), Postives = 86/170 (50.59%), Query Frame = 0

Query: 1255 YLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQK-WTVNGDTR---VGLFAKEDIKVNSELTFNY--QFEALGEVKTKCLCGAHNC 1418
            +++ EC          C N+     I  ++ V  T+  GWG+   +D+ KG F+ EYVGE+I++ E  TR  + L      +  Y   + +  IDA   GNIARF+NHSCDPN    K +  + D R   + LFA  DI   +EL F+Y  +F  +      C CG+ NC
Sbjct: 1151 HMIFECNDLCQCNVSTCHNRVVQHGITSRMIVFRTENMGWGVRALKDIAKGTFVCEYVGEIISDSEADTREDSYLF-----DLDYREGETY-CIDANRFGNIARFINHSCDPNLTPVKVFAEHQDLRFPHIALFANRDIPKGAELGFDYGEKFWVIKHKYFTCHCGSENC 1314          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000003894 (supercontig:LSalAtl2s:LSalAtl2s210:445414:449855:1 gene:EMLSAG00000003894 transcript:EMLSAT00000003894 description:"maker-LSalAtl2s210-snap-gene-4.18")

HSP 1 Score: 80.8777 bits (198), Expect = 2.117e-15
Identity = 89/362 (24.59%), Postives = 149/362 (41.16%), Query Frame = 0

Query: 1685 DYAKGKRIKERLKICPESNCQLIMRASNIGRHIKTRHPKMDESMALTAQYDESSFNGDSNDQIIVDPVPSPSQDILNGSLKNSGKERLKVCPIEECATKLRASNMSRHIKSKHPDFDESIAA-TAVFDPELSMDDSLQ--------MDNSFNDTDLFEGDEATHDKFGKE-------RLFTCKYCGVSLRASNLRRHIKARHEREDGQNPIYLSPSDGSSHPAFGLSGRRVQVK--CPACDLVLRPSNFNRHWARRHPAQPLPNVNERRQLYLEDDGEGFNEDGMAISVEPVFYGEGESSLPFNMEDESDGDESLNGDGKDGFECHFGTCHFVASNRRELAVHRRTLGHPKPGLNNSVRASE 2028
            D  + KR ++R  ICPE  C   +  SN GRH  ++HP + +   +  + +  + +G   D      +  P    +  S K + K+R  VC   EC   +  SN SRH  S+HP  D  + +   V D E+     L+          +    T  +  D+   D   ++            +          +++HI +         PI L+ ++ ++ P       RV+ K  C  C + +  SNF RHWA +H   P P + +   L   D  E  + +   +  EP+F+G  + S   N     DG   +       F+C +  C F +S++  L  HR   GH K   NN +++S+
Sbjct:   48 DGKERKRARQRNYICPE--CHRPLIGSNFGRHWASKHPHITQPSLINLEME--ALSGGEED------LAPPXPLSITSSPKPTVKKRKVVC--RECEMPMINSNFSRHWASRHPHLDMPLLSELEVIDVEVDASPPLKKPHKNPVIHQSHMPITIPYPSDDGDGDHLVQDIEPADEEFEDLEEIEDEDEDVMQIQQHISS--------TPI-LNSNNATNSPV------RVKRKIVCSECGMAMIGSNFGRHWASKHSHLPQPALQD---LVYADSAE--SGEAETVVCEPLFFGTEDLSEDENDNIHEDGGPVMEHLLLQSFQCGYERCSFSSSDKVSLYHHRSKCGHFK---NNGIQSSK 374          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000010500 (supercontig:LSalAtl2s:LSalAtl2s697:538829:550825:1 gene:EMLSAG00000010500 transcript:EMLSAT00000010500 description:"snap_masked-LSalAtl2s697-processed-gene-5.20")

HSP 1 Score: 71.633 bits (174), Expect = 3.933e-13
Identity = 54/183 (29.51%), Postives = 81/183 (44.26%), Query Frame = 0

Query: 1265 CPAKEKCLNQRFTKRIYPKLSVGLTQAR-GWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNH------RMIDAGPKGNIARFMNHSCDPNCET-QKWTVNGD---TRVGLFAKEDIKVNSELTFNYQFEALGE-----------VKTKCLCGAHNCSGFIGEK 1425
            C     C N+   K    KL +  T    GWG+   E++K G FI++Y G++IT++E + R +       E   Y   +D +        +DA   GN+A F+NHSCDPN      W    D    R+ LFA+ DI    +LTF+Y      +            +  C CG   C  ++ E+
Sbjct:  137 CKCDSSCSNRVVQKGRMIKLCIFRTDNDCGWGVKTLENIKCGSFIVDYAGQVITSEEAEERGKQY---DSEGRTYLFDLDFNLGDECPYTVDAANFGNVAHFINHSCDPNLAIFNVWIDCLDPNLPRLCLFAQRDIIKGEQLTFDYCQSTTADNSVSSSLLNKNNRMLCRCGTSKCRKWLFER 316          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000003515 (supercontig:LSalAtl2s:LSalAtl2s191:6249:9076:-1 gene:EMLSAG00000003515 transcript:EMLSAT00000003515 description:"maker-LSalAtl2s191-augustus-gene-0.18")

HSP 1 Score: 58.5362 bits (140), Expect = 2.033e-8
Identity = 39/129 (30.23%), Postives = 60/129 (46.51%), Query Frame = 0

Query:  549 EGCMLWARVGGAPYWPCAVINDPDLGIYTRV--SHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEFLLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQL 675
            EGC+LWA++ G  YWP     DP  G+ ++V  S +R     + H+ F      RAWV  + ++ YEG E+F           K    K P  K     GK  +  ++ AV+ AE  + +    R+ +L
Sbjct:   74 EGCLLWAKIRGFSYWPGITTVDPYEGVTSKVIESSKRT----KTHIHFLAYDNLRAWVNESDVLSYEGYEKF-----------KELAYKFPKRKKDFEPGKKFRNIFERAVKEAEAXMCIPVALRLEKL 187          

HSP 2 Score: 53.9138 bits (128), Expect = 4.958e-7
Identity = 40/123 (32.52%), Postives = 53/123 (43.09%), Query Frame = 0

Query:  550 GCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF-LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQER 671
            G ++W  + G PYWPC V    D G Y R +  +  V    HVQFF    +  WV     M +  + EF     EA+K D+       P        GK+    W  A   AE T+ LS +ER
Sbjct:  296 GTLIWGHMAGFPYWPCFVTRSSD-GDYIREAKNKISV----HVQFFNWNDESGWVTKT--MPWCSVAEFRRFAKEAIKEDVSCSMDWSPV-------GKMLH-KWKNAALQAESTVHLSRKER 403          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. L. salmonis genes
Match: EMLSAG00000003694 (supercontig:LSalAtl2s:LSalAtl2s1:1918656:1933929:1 gene:EMLSAG00000003694 transcript:EMLSAT00000003694 description:"maker-LSalAtl2s1-augustus-gene-19.16")

HSP 1 Score: 53.1434 bits (126), Expect = 9.036e-7
Identity = 31/90 (34.44%), Postives = 50/90 (55.56%), Query Frame = 0

Query: 1338 YYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNG-DTR---VGLFAKEDIKVNSELTFNYQFEALGEVKTK---CLCGAHNCSG 1420
            Y+   ++  ++DA   GN+ R++NHSC+PN   Q   V+  D R   +  FA   I+  +EL ++Y +  + +V+ K   C CGA NC G
Sbjct:  627 YFGKNEDVYIMDAKTIGNVGRYLNHSCNPNIFVQNCFVDXHDLRYPWIAFFASSFIRAGTELCWDYCY-IVDQVEGKEIYCECGASNCRG 715          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|68565655|sp|O88491.1|NSD1_MOUSE (RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; AltName: Full=H3-K36-HMTase; AltName: Full=H4-K20-HMTase; AltName: Full=Nuclear receptor-binding SET domain-containing protein 1; Short=NR-binding SET domain-containing protein)

HSP 1 Score: 665.611 bits (1716), Expect = 0.000e+0
Identity = 314/689 (45.57%), Postives = 435/689 (63.13%), Query Frame = 0

Query:  863 GVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDV---DKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVN---GNGLKKKKGKSKRSKKKVW---EDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDTAVENHAEL-GNI-CDEHE 1539
            G   KE+ C  CE++     +L+ C+  C  +FH  CL +    +  + C EC +G H C +CK  G+DV RC    CG+F+H +C+++   +P +   +  F CP+H+C TC + NP   +     RL++C+RCP AYH+ D+C+ AG+  + S+ I+CP H+TP    +      HVN +WCF+CS+GGSL+CC+ CPA+FH ECL+I  P+G +YC+ C+ G+ P Y EIVWVK+G YRWWPA++ HP  VP+NI+ + H++GEFP+ F GS +Y W +Q R F Y +GDV   DK+     KG++G +K+ LQEA   F      K+LR+    ++  +  + KPP Y  IK NRP G   ++T D S+   C+C   + +PCG DS+C+NR L+ EC P+ CPA  +C NQ F+KR YP + +  T  RGWGL    D+KKG+F+ EYVGELI  +E + R++ +    + +NFY +T+D  R+IDAGPKGN ARFMNH C PNCETQKW+VNGDTRVGLFA  DIK  +ELTFNY  E LG  KT C CGA NCSGF+G +PK+   V        K+K    +RS+ +V    ED CF C D GQL+ C    CPKVYH +CL   K P  KW CPWH C  CGK A ++C  CP+++CK H   +   ++L G + C EH+
Sbjct: 1436 GAALKENVCQNCEKL----GELLLCEAQCCGAFHLECLGLPEMPRGKFICNECHTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQK---YPPTVTQNKGFRCPLHICITCHAANPAN-VSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP---RRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKM----GKGVDGTYKKALQEAAARFEELKARKELRQ----LQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQ-EHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2104          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|32469769|sp|Q96L73.1|NSD1_HUMAN (RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; AltName: Full=Androgen receptor coactivator 267 kDa protein; AltName: Full=Androgen receptor-associated protein of 267 kDa; AltName: Full=H3-K36-HMTase; AltName: Full=H4-K20-HMTase; AltName: Full=Lysine N-methyltransferase 3B; AltName: Full=Nuclear receptor-binding SET domain-containing protein 1; Short=NR-binding SET domain-containing protein)

HSP 1 Score: 655.596 bits (1690), Expect = 0.000e+0
Identity = 312/689 (45.28%), Postives = 434/689 (62.99%), Query Frame = 0

Query:  863 GVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDV---DKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKD---GKNVNGNGLKKKKGKSKRSKKKVW---EDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDTAVENHAEL-GNI-CDEHE 1539
            G   KE+ C  CE++     +L+ C+  C  +FH  CL +    +  + C EC +G H C +CK  G+DV RC    CG+F+H +C+++   +P + + +  F C +H+C TC + NP   +     RL++C+RCP AYH+ D+C+ AG+  + S+ I+CP H+TP    +      HVN +WCF+CS+GGSL+CC+ CPA+FH ECL+I  P+G +YC+ C+ G+ P Y EIVWVK+G YRWWPA++ HP  VP+NI+ + H++GEFP+ F GS +Y W +Q R F Y +GDV   DK+     KG++G +K+ LQEA   F      K+LR+     K     + KPP Y  IK NRP G   ++T D S+   C+C   + +PCG DS+C+NR L+ EC P+ CPA  +C NQ F+KR YP++ +  T  RGWGL    D+KKG+F+ EYVGELI  +E + R++ +    + +NFY +T+D  R+IDAGPKGN ARFMNH C PNCETQKW+VNGDTRVGLFA  DIK  +ELTFNY  E LG  KT C CGA NCSGF+G +PK+            KKK+   +R++ ++    ED CF C D GQL+ C    CPKVYH +CL   K P  KW CPWH C  CGK A ++C  CP+++CK H   +   ++L G + C EH+
Sbjct: 1538 GAALKENVCQNCEKL----GELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQK---YPPTVMQNKGFRCSLHICITCHAANPAN-VSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP---RRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKM----GKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRK----NDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQ-EHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2206          

HSP 2 Score: 72.4034 bits (176), Expect = 4.286e-11
Identity = 36/101 (35.64%), Postives = 59/101 (58.42%), Query Frame = 0

Query:  542 ASPASFEEGCMLWARVGGAPYWPCAVINDPDLGIYT--RVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEG---IEEFLLKTEAVKNDLKGKKSKLP 637
            ++P  +E G ++WA+    P+WPC + +DP +  ++  +VS+RR Y  R+Y+V+ FG   +RAWV   AI+ +EG    EE  +     K   KG + K+P
Sbjct:  316 STPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPY--RQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVP 414          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|118572947|sp|Q8BVE8.2|NSD2_MOUSE (RecName: Full=Histone-lysine N-methyltransferase NSD2; AltName: Full=Multiple myeloma SET domain-containing protein; Short=MMSET; AltName: Full=Nuclear SET domain-containing protein 2; AltName: Full=Wolf-Hirschhorn syndrome candidate 1 protein homolog)

HSP 1 Score: 647.506 bits (1669), Expect = 0.000e+0
Identity = 323/719 (44.92%), Postives = 433/719 (60.22%), Query Frame = 0

Query:  833 DEASVSSSVKSSKFVEPRQEKENRQPSEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGN------GLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHD--TAVENHAELGNICDEHE 1539
            DE    +SV S K             SE     KKE+ C +CE+       L+ C+G C  +FH +CL +    +  + C ECASG H+C +CK    +V RC    CG+F+H  C+++   +P +      F CP+H C +C + NP  P      ++++C+RCP AYH GD C+ AG   I S+ I+C  H+T     K      HVN +WCF+CSKGGSL+CCE CPA+FH +CL+I  PDG ++C+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   FN     ++ RE        Q    KPP Y  IK N+P+G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E C NQ FTKR YP+  +  T  +GWGLV   D++KG+F+ EYVGELI  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK   +++          K ++ ++K   K+  ED CFRC D GQL++CD K C K YHL CLG  K P  KW CPWHHC  CGK + ++C  CPN++CK H   TA  +  +  + C EH+
Sbjct:  645 DETQTEASVSSKK-------------SERGMAAKKEYVCQLCEKT----GSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCMSCHASNPSNPRPS-KGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---RKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARET-------QESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHD 1327          

HSP 2 Score: 82.8037 bits (203), Expect = 2.896e-14
Identity = 46/127 (36.22%), Postives = 76/127 (59.84%), Query Frame = 0

Query:  547 FEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQER 671
            +  G ++W++V G P+WPC V  DP L  +T++  ++    R+YHVQFFG   +RAW+   +++ +EG E+F  L +  A +   K +K KL  LK   I G++ +A W+  +  AE+  S+S +ER
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSA-RQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKL--LKP--ISGRL-RAQWEMGIVQAEEAASMSIEER 340          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|74706096|sp|O96028.1|NSD2_HUMAN (RecName: Full=Histone-lysine N-methyltransferase NSD2; AltName: Full=Multiple myeloma SET domain-containing protein; Short=MMSET; AltName: Full=Nuclear SET domain-containing protein 2; AltName: Full=Protein trithorax-5; AltName: Full=Wolf-Hirschhorn syndrome candidate 1 protein)

HSP 1 Score: 644.81 bits (1662), Expect = 0.000e+0
Identity = 318/686 (46.36%), Postives = 425/686 (61.95%), Query Frame = 0

Query:  866 KKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGN------GLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHD--TAVENHAELGNICDEHE 1539
            KKE+ C +CE+   P S L+ C+G C  +FH +CL +    +  + C+ECASG H+C +CK    DV RC    CG+F+H  C+++   +P +      F CP+H C +C + NP  P      ++++C+RCP AYHSGD C+ AG   I S+ I+C  H+T     K      HVN +WCF+CSKGGSL+CCE CPA+FH +CL+I  PDG ++C+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   F      ++ RE        Q    KPP Y  IK N+P+G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E C NQ FTKR YP+  +  T  +GWGLV   D++KG+F+ EYVGELI  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK    ++          K ++ ++K   K+  ED CFRC D GQL++CD K C K YHL CLG  K P  KW CPWHHC  CGK + ++C  CPN++CK H   TA     +  + C EH+
Sbjct:  665 KKEYVCQLCEK---PGS-LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCVSCHASNPSNPRPS-KGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA---RKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGVRGIGRVFKNALQEAEARFREIKLQREARET-------QESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1327          

HSP 2 Score: 85.5001 bits (210), Expect = 4.306e-15
Identity = 65/208 (31.25%), Postives = 104/208 (50.00%), Query Frame = 0

Query:  547 FEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSA-----VSEEEFPAKRGRFDMAEELIQAIAPETLEAH 747
            +  G ++W++V G P+WPC V  DP L  YT++  ++    R+YHVQFFG   +RAW+   +++ +EG  +F  L +  A +   K +K KL  LK   I GK+ +A W+  +  AE+  S+S +ER  +     Y    +    + +  + I+  S      +SG +  +A     V EE  P KR R           + ETLE+H
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSA-RQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKL--LKP--ISGKL-RAQWEMGIVQAEEAASMSVEERKAKF-TFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRR-----RAKLCSSAETLESH 415          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|74761342|sp|Q9BZ95.1|NSD3_HUMAN (RecName: Full=Histone-lysine N-methyltransferase NSD3; AltName: Full=Nuclear SET domain-containing protein 3; AltName: Full=Protein whistle; AltName: Full=WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; AltName: Full=Wolf-Hirschhorn syndrome candidate 1-like protein 1; Short=WHSC1-like protein 1)

HSP 1 Score: 605.905 bits (1561), Expect = 0.000e+0
Identity = 305/735 (41.50%), Postives = 416/735 (56.60%), Query Frame = 0

Query:  863 GVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCS-------------------------------------------------KGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDG------KNVNGNGLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDTA--VENHAELGNICDEHE 1539
            G+ KK+  C ICE   +    LI C+G C   FH  CL + +     + C EC +G H C  CK  G+DV RCS   CG+F+H  C+R+   +P +      F CP H C  C+ +  K+       R+++C+RCP AYHSGD C+ AG++ ++S  ++C  H      +K+SS S  VN  +CF+C+                                                 KGG L+CCE CPASFH ECL I  P+G + C+ C+ G+   Y +IVWVKLG YRWWPA++ +P  VP NI+ L H++G+FP+ F GS +Y+W++QGR F Y +GD     G  S  +N  FK+ L+EA + F      ++ +EA    K     + KPP Y  IK N+  G   +   D S+   C+C   + +PCG +S+CLNR L  EC P  CPA ++C NQ FTKR+YP   +  T+ RGWGL     +KKG+F+ EYVGELI  +E + R++ +      +NFY +T+   R+IDAGPKGN +RFMNHSC+PNCETQKWTVNGD RVGLFA  DI    ELTFNY  + LG  +T+C CGA NCSGF+G +PK        +      LK+K+ K K   K++ ED CF+C D G+L+MCD K CPK YHL CL   + P  KW CPWH C  C   AV++C  CP+++CK H+    V +  E    C EH+
Sbjct:  696 GMSKKDTVCQICESSGD---SLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRK---FPTAIFESKGFRCPQHCCSACSME--KDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNH------SKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTS--INKTFKKALEEAAKRFQELKAQRESKEALEIEK----NSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAH-ENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409          

HSP 2 Score: 95.5153 bits (236), Expect = 4.005e-18
Identity = 59/197 (29.95%), Postives = 98/197 (49.75%), Query Frame = 0

Query:  540 DLASPASFEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEG---IEEFLLK-TEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKR----------NTSGGTVGSAVSEEEF 722
            ++++   F+ G ++W++VG  P+WPC V +DP L ++T+++ R     REYHVQFF    +RAWV    + EY+G    EE L + T+   N  + +K + P  +         +A WD  +  AEK L ++ +ER+ Q   +  D+ P     +   S    T  +K +R           T+ G V S++S  E 
Sbjct:  261 EVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGA---REYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQR-------ERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEI 447          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|118572948|sp|Q6P2L6.2|NSD3_MOUSE (RecName: Full=Histone-lysine N-methyltransferase NSD3; AltName: Full=Nuclear SET domain-containing protein 3; AltName: Full=Wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog; Short=WHSC1-like protein 1)

HSP 1 Score: 595.119 bits (1533), Expect = 1.829e-180
Identity = 303/733 (41.34%), Postives = 411/733 (56.07%), Query Frame = 0

Query:  862 IGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCS-------------------------------------------------KGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYR---WWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDG-----KNVNGNGLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDT-AVENHAELGNIC 1535
            +G  KK+  C +CE+  +    L+ C+G C   FH  CL +    +  + C EC +G H C  CK  G+DV RCS + CG+F+H  C+R+   +P +      F CP H C +C+ +  K+       R+++C+RCP AYH GD CV AG+V ++S  ++C  H      +K+SS S  +N  +CF+C+                                                 KGG L+CCE CPASFH ECL I  P+G + C+ C+ G+   Y +IVWVKLG YR   WWPA++  P  VP NI+ L H++G+FP+ F GS +Y+W++QGR F Y +GD     G  S  +N  FK+ L+EA + F      ++ +EA    +  +    KPP Y  IK N+  G   V   D S+   C+C   + +PCG +S CLNR    EC P  CPA ++C NQ FTKR+YP   V  T+ RGWGL     +KKG+F+ EYVGELI  +E + R++ +      +NFY +T+   R+IDAGPKGN +RFMNHSC+PNCETQKWTVNGD RVGLFA  DI    ELTFNY  + LG  +T C CGA NCSGF+G +PK            N   KK+ K K   K + ED CF+C D G+L+MCD K CPK YHL CL   + P  KW CPWH C  CG +AV++C  CP+++CK H   A+   A  G +C
Sbjct:  695 VGTSKKDTVCQVCEKAGD---CLVACEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVRK---FPTAIFESKGFRCPQHCCSSCSME--KDIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNH------SKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRQVLWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTS--INKTFKKALEEAAKRFQELKAQRESKEALEMERTSR----KPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAH-ENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAVDEKTKNAKLKKRRKVKAEAKPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGKGALVPSALEGRLC 1406          

HSP 2 Score: 93.9745 bits (232), Expect = 1.327e-17
Identity = 64/223 (28.70%), Postives = 105/223 (47.09%), Query Frame = 0

Query:  508 PDLNSASPIQVLKREVHRSTTPEELAEKARQFDLASPASFEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKR----------NTSGGTVGSAVS 718
            P L  A P+Q +   V  + T             ++   F+ G ++W++VG  P+WPC V +DP L ++++++ R     REYHVQFF    +RAWV    + EY+G E++  LL   A +     +K K+   +      +  +A WD  +  AEK L ++ +ERV Q   +  D+ P     +   + T  T  +K +R           T+ G V S+ S
Sbjct:  242 PVLKEAIPVQPILSSVPTTET-------------STGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKINTRGA---REYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNHSEKQKIRKPRP-----QRERAQWDIGIAHAEKALKMTREERVEQYTFIYIDKQPEEASSQAKKNVTSKTEVKKPRRPRSVLNSQPEQTNAGEVASSQS 443          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|29427833|sp|Q8MT36.2|MES4_DROME (RecName: Full=Probable histone-lysine N-methyltransferase Mes-4; AltName: Full=Maternal-effect sterile 4 homolog)

HSP 1 Score: 436.032 bits (1120), Expect = 2.621e-125
Identity = 224/526 (42.59%), Postives = 310/526 (58.94%), Query Frame = 0

Query:  935 CSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKY-NSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFY-CDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKG-LNGAFKRGLQEA---LEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPV-YTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEAL-GEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGKSKRSKKKV 1451
            CS   CG+ FH  C +    WPQ+  S     CP H+CHTC SD+P     +  +S+L KC+RCP  YH    C+ AGT  + ++ I+CP+H         +    HVN  WC++C KGG L+CCE CP + HA C +I       Y C+ CE GR+PLYGEIVW K   +RWWPA +L P+EVP+NI    H   +F ++F G+ ++ WI++ R +LY +GD     G+ +K  L   +  G++EA   L +  A  +++D+   S          L PP Y KIKTN+     P+ ++++  D  TC+C   +  PCGP++ CLNR L  EC P  C A   C N+ F +R  P+L V     RG+GLV  E +  GDF+IEYVGE+I + EFQ R++    R  + N+Y++ ++   +IDAGPKGN+ARFMNHSC+PNCETQKWTVN   RVG+FA +DI VNSELTFNY ++ L    K  C CGA  CSG IG K KD   V  +   K+  ++K S  ++
Sbjct:  900 CSQPMCGKRFHTSCCK---YWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNI-------AKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGD--GHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGN-------KLHPPPYVKIKTNKAVP--PLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQ-RDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLKDDA-VKAHAKLKQMRRAKASAVRI 1402          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|544604608|sp|E9Q5F9.1|SETD2_MOUSE (RecName: Full=Histone-lysine N-methyltransferase SETD2; AltName: Full=Lysine N-methyltransferase 3A; AltName: Full=Protein-lysine N-methyltransferase SETD2; AltName: Full=SET domain-containing protein 2)

HSP 1 Score: 197.978 bits (502), Expect = 4.276e-49
Identity = 94/222 (42.34%), Postives = 138/222 (62.16%), Query Frame = 0

Query: 1245 CGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGKSKRSKKKVWEDLCFRCMDDGQLL 1466
            CG   DCLNR LM+EC  S CP  + C N+RF ++ +  + V LT+ +GWGL   +D+    F++EY GE++ + EF+ R++    R +  ++Y+M + N  +IDA  KGN +RFMNHSC+PNCETQKWTVNG  RVG F  + +   SELTF+YQF+  G+   KC CG+ NC G++G + +      G  +KK++ + K S     E L    M++G+ L
Sbjct: 1490 CG--EDCLNRLLMIECS-SRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVK-EYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEAL----MENGEGL 1703          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|296452963|sp|Q9BYW2.3|SETD2_HUMAN (RecName: Full=Histone-lysine N-methyltransferase SETD2; AltName: Full=HIF-1; AltName: Full=Huntingtin yeast partner B; AltName: Full=Huntingtin-interacting protein 1; Short=HIP-1; AltName: Full=Huntingtin-interacting protein B; AltName: Full=Lysine N-methyltransferase 3A; AltName: Full=Protein-lysine N-methyltransferase SETD2; AltName: Full=SET domain-containing protein 2; Short=hSET2; AltName: Full=p231HBP)

HSP 1 Score: 197.593 bits (501), Expect = 5.047e-49
Identity = 94/222 (42.34%), Postives = 138/222 (62.16%), Query Frame = 0

Query: 1245 CGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGKSKRSKKKVWEDLCFRCMDDGQLL 1466
            CG   DCLNR LM+EC  S CP  + C N+RF ++ +  + V LT+ +GWGL   +D+    F++EY GE++ + EF+ R++    R +  ++Y+M + N  +IDA  KGN +RFMNHSC+PNCETQKWTVNG  RVG F  + +   SELTF+YQF+  G+   KC CG+ NC G++G + +      G  +KK++ + K S     E L    M++G+ L
Sbjct: 1516 CG--EDCLNRLLMIECS-SRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVK-EYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEAL----MENGEGL 1729          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. SwissProt
Match: gi|94707110|sp|Q2LAE1.1|ASHH2_ARATH (RecName: Full=Histone-lysine N-methyltransferase ASHH2; AltName: Full=ASH1 homolog 2; AltName: Full=H3-K4-HMTase; AltName: Full=Histone H3-K36 methyltransferase 8; Short=H3-K36-HMTase 8; AltName: Full=Protein EARLY FLOWERING IN SHORT DAYS; AltName: Full=Protein LAZARUS 2; AltName: Full=Protein SET DOMAIN GROUP 8)

HSP 1 Score: 190.66 bits (483), Expect = 4.719e-47
Identity = 95/248 (38.31%), Postives = 141/248 (56.85%), Query Frame = 0

Query: 1183 NAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASDKTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQF-EALGEVKTKCLCGAHNCSGFIGEKPKDG 1429
            +AY  D   R      K++++   +   +  IKTN+                C C        G   +CLNR L +EC   +CPA + C NQ+F KR Y K     +  +G+GL + EDV++G F+IEYVGE++    ++TR Q     K + +FY+MT++ + +IDAG KGN+ RF+NHSC+PNC T+KW VNG+  VG+F+ +D+K   ELTF+Y +    G    KC CG+ +C G+IG  P +G
Sbjct:  927 DAYDCDAAKRGKEKEQKSKRLTGKQKACFKAIKTNQFLHRNRKSQTIDEIMVCHCKPSPDGRLGCGEECLNRMLNIECLQGTCPAGDLCSNQQFQKRKYVKFERFQSGKKGYGLRLLEDVREGQFLIEYVGEVLDMQSYETR-QKEYAFKGQKHFYFMTLNGNEVIDAGAKGNLGRFINHSCEPNCRTEKWMVNGEICVGIFSMQDLKKGQELTFDYNYVRVFGAAAKKCYCGSSHCRGYIGGDPLNG 1173          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|1325277565|ref|XP_023323420.1| (uncharacterized protein LOC111697599 [Eurytemora affinis])

HSP 1 Score: 833.173 bits (2151), Expect = 0.000e+0
Identity = 384/756 (50.79%), Postives = 508/756 (67.20%), Query Frame = 0

Query:  866 KKEHCCIICEEVTNPK-SDLIKCKGMCGHSFHESCLQI--ETTNKDDWKCAECASGNHACQICKGYGQD-----------VSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGKS----------------KRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVN---YCMHCPNAYCKTHDTAVENHAELGNICDEHEDDFEDLLNFYNKVGGISKLVPHPNVPMEEPSNDALLTPNGVKKPLTEI 1587
            + E CC  CE VT+    ++ KCKG+CG+S+H SCL +  +   +D WKC +C +G  +C +C G+ +            V RC   GCG+++H  C+  + LWPQ+R+ ++  +CP HMCHTCASD+PK P+MKY  +L++CIRCPTAYH  D+C+TAGT+ IT + I+CPKHY PP   KK+    HVN +WCF+CS GGS+ICCE CPA+FH ECL +  P   +YCD+CE GRMPLY E+VW K+G YRWWPA V+ P ++P  IE LPH+ GEFP+QF GS +Y WINQGR FLYE+GD +K+P  +SK ++  F+RGL+ A E++ AYTK++  RE  +  K       KP  Y K+K+NRP+G+CPVYT D  D   CDCD +   PCG DS+C+NR LM EC    C AK+KC N RF KR YP L V   + RGWGL+  E +KK  F+IEYVGELIT +E++ R++ +   KEE N+YY+T+DN+RMIDAGPKGN ARFMNHSCDPNC TQKW+VNGDTRVGLF  +D+KV  ELTFNYQ E++G+VK KCLCGA NCSGFIGEKPK+ K  N    +++K  +                K +  K+WE  CFRC + G L+ C+   CPK YHL C+G+E  PR KW CPWH+C+ CGKL      +C+HCPNAYC+ H  ++  H EL  IC EH D+ E L+      GGI+++ P PN  +++ S  A     G+ + + E+
Sbjct:   52 RYERCCAKCESVTSEVLGEVWKCKGLCGNSYHLSCLGLNPKEEEEDKWKCIDCCAGILSCSLC-GHREGETTASGLKCGPVRRCGSNGCGKWYHETCITGSPLWPQARVGNSSLICPAHMCHTCASDDPKNPVMKYKEKLIRCIRCPTAYHHNDHCMTAGTLIITKNDILCPKHYKPPAKNKKN---FHVNASWCFMCSTGGSIICCEICPAAFHLECLKLEHPPEKYYCDNCETGRMPLYNEVVWAKIGAYRWWPALVVPPEKLPNKIEMLPHQEGEFPVQFLGSGDYAWINQGRAFLYEEGDSEKVPDMSSKSMDATFRRGLKSAEELYAAYTKEQSAREEKAATKRNY--GSKPAPYVKLKSNRPYGNCPVYTVDPGDLHPCDCDPNKPGPCGEDSNCINRMLMFECHTQVCNAKDKCENMRFQKRQYPALKVHRAEGRGWGLIAEEPIKKSSFVIEYVGELITMEEYRNRMKMNQDSKEE-NYYYLTIDNNRMIDAGPKGNSARFMNHSCDPNCITQKWSVNGDTRVGLFTIKDVKVGEELTFNYQLESVGDVKKKCLCGAANCSGFIGEKPKNEKEDNKRKEQEQKKNNKKALKKLKKKEEQKIRKDNNAKIWESTCFRCHESGSLIQCEMGLCPKSYHLSCIGKETFPRGKWHCPWHYCIDCGKLVEGQNAWCIHCPNAYCRQHRDSLVQHPELSWICREHGDEMEFLIETLRSGGGIAEIFPSPNPTLKQIS--AWKRARGISEFVAEV 798          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|1238850107|ref|XP_022242981.1| (LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2-like [Limulus polyphemus])

HSP 1 Score: 729.939 bits (1883), Expect = 0.000e+0
Identity = 413/1074 (38.45%), Postives = 577/1074 (53.72%), Query Frame = 0

Query:  544 PASFEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEG---IEEFLLK-TEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSAVSEEEFPAKRGRFDMAEELIQAIAPETLEAHRRKLK--------------------------TGFKLFQLANLERIRRDSADHTEA--ERKLGKMWAGVSGMERKFY------------QEQASNLGQSDPVDDSQSSLQEDDD--------YV---ILDSEDEAFNDEASVSSSVKSSKFVEPRQEKENRQPSEMIG------------VWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTED-ASDKTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGK-------SKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDTAVENHAELGNI-CDEHEDD 1541
            PA +  G +LW+++ G P+WPC V  DP  G Y++V   R  + R YHVQ+FG      W     ++ YEG    EE++ K   A+    K +   L   K         K AW+ AVE AE  L +S  ER  +L   T+ Q  +P+Q +    S +   S+K   +         +  ++   K+ +    + L + +A  T +    K+K                            F +F   NL+  R    D T+   E  L + W  +   ++  Y            QE+A   G  +   +S  S  ++D         Y+   + D+E     +E  +   +      +P + KE +Q  +M+               ++E  C ICE+V     D + CKG C  SFH SCL + T     + C EC +G H C +CK     + +CS + CGRF+H  CL +  L   SR     F+CP+H CH+C +DNPK+   +  +R ++CIRCPTAYH G+ C+ AG+V +  + ++C  H+ P    K      HVN +WCF+CS GGSLICCE CPA+FHAECL +  P+G ++C+ C++ + P YG+IVWVKLG YRWWP K+ +P  VP+NI+ L H++GEFPI+F GS EY+W ++GR FL+ +GD         + L   F + ++EA   F  +   ++ R   +       K+ KPP +  IK+N+P G   +YT D  S   C+CD ++ +PC  + DCLNR LM EC PSSCPA++KC NQRF KR Y        + RGWGL    DVKKG+F+ EYVGELI  +E Q RL+  +  + ++NFY++T+D  R+IDAGPKGN++RFMNHSC PNCETQKW VNGDTRVGLFA  DI   SELTFNY  E  G+ KTKC+CGA NCSGFIG +PK         L++K+ K        K  K    ED CFRC + G++LMCD K CPK YHL CL   K P  KW CPWHHC  CGK ++  C+ CPN++CK H T     A  G   C +H D+
Sbjct:  429 PAEWLVGDLLWSKISGHPWWPCMVSFDPIQGTYSKVIRVRT-LFRIYHVQYFGHEAHHGWTKPGCVLAYEGKDKFEEYVKKFVAAIPRGCKNRDKLLAKFKI----TSARKKAWELAVEEAEDALRMSRAERKQEL---TF-QYVMPKQNK----SAVDVDSQKLDNSDVNKNKKLTLHHKKSSVKKPQMSECKILKEELATNTKKICSHKMKGSINFKNKNPEKKLQEKHSSWKAEKNNSFSVFCKRNLDEKRLQHPDFTDVALEDLLYQEWVKMIDFQKAQYTLGKLENVHISAQEKAKIKGMKNLKPNSSLSKMKNDKNKSCKKSRYMCDKVKDTEKSRTCEEKILGKDIT---IKDPVERKEPKQSCKMVTQELVEGKQATGITARQERVCYICEKV----GDTVICKGPCLKSFHPSCLGL-TQVPSTFMCDECMTGKHLCFVCKVGEDKIRKCSVSNCGRFYHERCLLKYQL--TSRTEGRGFICPLHTCHSCVADNPKQS--RSRARYIRCIRCPTAYHMGESCIAAGSVILNPTHMICANHFCP---KKGRQYQTHVNVSWCFICSIGGSLICCESCPAAFHAECLDVEAPEGSYFCEDCKMRKHPHYGDIVWVKLGPYRWWPGKICYPLSVPSNIQKLEHDVGEFPIKFFGSHEYYWTHRGRVFLFHEGDRGSKEKFPYRHLAKVFLKAVEEADTAFKEWQTSREARSLEAG------KSSKPPFFKYIKSNKPVGKVQIYTVDLLSLNRCECDPNSKNPCSNEIDCLNRVLMFEC-PSSCPAEDKCQNQRFQKRQYVPARPFEVKDRGWGLQTLIDVKKGEFVTEYVGELIDEEECQKRLK-QMHEENDTNFYFLTIDKDRIIDAGPKGNLSRFMNHSCQPNCETQKWMVNGDTRVGLFAICDISAGSELTFNYNLECRGDEKTKCMCGAPNCSGFIGVRPK----TTALALQEKRAKETLIKKKKKNLKXPKHEDECFRCGEGGEILMCDKKGCPKAYHLNCLNLTKPPYGKWECPWHHCDECGKASIILCVECPNSFCKEHGTPENVFAVDGQFYCSDHRDE 1462          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|1139825216|ref|XP_019927970.1| (PREDICTED: histone-lysine N-methyltransferase NSD2 [Crassostrea gigas])

HSP 1 Score: 710.679 bits (1833), Expect = 0.000e+0
Identity = 417/1049 (39.75%), Postives = 585/1049 (55.77%), Query Frame = 0

Query:  519 LKREVHRSTT-PEELAEKARQFDLASPASFEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEFLLKTEAVKNDL--KGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRT-SGSSTISTAS---------RKRKRNTSGGTVGS-AVSEEEFPA-KRGRFDMAEELIQAIAPETLEAHRRKLKTG-FKLFQLANLERIRRDSADHTEAERK--LGKMWAGVSGMERKFYQEQASNLGQSDPVDDSQSSLQEDDDYVILDSEDEAFNDEASVSS-SVKSSKFVEPRQEKENRQPSEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTED-ASDKTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGKSKRSK-------KKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDTAVENHAELGNICDEHED 1540
            L+ EV++STT    + EK        PA ++ G  LWA+V G P+WPC V  DP   +YT++  R     R YHV FFG   +R W  SN+IME++G +++    E VK       K  KL   K Y  Y    +AAW  A+  AE+ +++S +ERV + + V    P   +++ T SG+      S         +KRKR +S     S A S    P+ KR R D               +H+ K   G F++F   + + +  D  +  EA     L + W  +S  ++  Y+ +     Q  P +   S + E       + ++++  +   V+   +K  K        +N++  +        + C +CE+      DL++C+G C + FH+SC  +    ++ +KC EC SG H C  CK   ++  +CS   CG+F+H +CL +  L      S+  FVCP+H C TCA ++ K+       RLL+C+RCPTAYH+GD+C+ AG+  +    IVC KH+ P    K  +   H+N +WCF+C+ GGSLICC+ CPASFHAECL+I+ P+G +YC+ C +G+ PLYG+IVWVKLG YRWWP+++ HP  VP NI+   H++GEFP+ F G+ +YFWI++GR F ++DGD      + +K L   F RG+QEA E F A    +  +E     ++ +    KP  +  +K N P G   +   D  S   C+CD ++ +PC  D+DCLNR LM EC PS C   EKC NQRF +R YP  +   T+ RGWGL    D+KKG F+ EYVGELI  +E + R+  S      SN+Y +T+D +R+IDAGPKGN++RFMNHSC PNCETQKWT NGD RVGLFA  DI   +ELTFNY  E LG  KTKC CGA  CSGF+G +PK     +    KKK  K KR +       KK  +D CFRC + G+L+MCD   CPKVYHL CL   K P  KW CPWHHC  CGK A+  C  CPN++C TH        +   +C EH++
Sbjct:  209 LEPEVNKSTTFTSPVVEK--------PAEWKMGDQLWAKVAGHPWWPCMVAKDPYEDLYTKMKARS----RLYHVTFFGNEGERGWAGSNSIMEFKGKDKY---DEHVKQAFLNAKKGEKLKLEKLYREYPN-RQAAWLIAIHQAEEAMTMSVEERVEKFKCVC--TPEKKKKKSTDSGNDNKQVKSPKGKSKERIQKRKRQSSEQVKSSPAPSPAAKPSSKRRRLDEGS------------SHKDKKSEGSFEVFCSKHRDSMMADHPEFDEATLNECLQQQWLMMSQKQKSRYKSKL----QDTPKEPVISKVAERKMSPTEEEDEDSEKETKIVAKLKLKREKSTSDESSSDNQEEEKNSLCKSPRYLCQVCED----NGDLMECEGECHNYFHKSC--VSENVEEPFKCEECKSGVHTCFACKEKDENTKKCSVHLCGKFYHENCLNK--LMHSKSDSNKGFVCPLHQCATCAIESSKKTKAS-KGRLLRCVRCPTAYHTGDFCIAAGSENLPGHNIVCSKHFQPNRTQKYHT---HINVSWCFVCNLGGSLICCDSCPASFHAECLNINPPEGNWYCNDCAMGKQPLYGDIVWVKLGSYRWWPSEICHPKRVPHNIQEKTHQVGEFPVHFFGTNDYFWIHKGRAFGFQDGDKYSKETSKNKHLAKIFARGVQEATEAFQALKALRADKEKMFIERSEK----KPAPFKFVKNNIPVGSVVIPKPDLTSIPRCECDPNSEAPCSSDTDCLNRMLMYECHPSVCQCGEKCHNQRFQRREYPDCTPFKTEGRGWGLRTNVDIKKGQFVHEYVGELIDEEEVKRRIDESH-ENNISNYYMLTLDKNRVIDAGPKGNLSRFMNHSCAPNCETQKWTANGDVRVGLFAIYDIPAGTELTFNYNLECLGNDKTKCNCGAELCSGFLGVRPKSAVAASVAKGKKKDEKKKRKRNKKKIDGKKEHDDECFRCGEGGELVMCDRGGCPKVYHLHCLKLSKPPHGKWDCPWHHCDECGKPAITMCTECPNSFCATHTEGHIKEVDGVAVCSEHDE 1206          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|908441785|ref|XP_013079322.1| (PREDICTED: histone-lysine N-methyltransferase NSD2-like [Biomphalaria glabrata])

HSP 1 Score: 709.138 bits (1829), Expect = 0.000e+0
Identity = 412/1108 (37.18%), Postives = 583/1108 (52.62%), Query Frame = 0

Query:  516 IQVLKREVHRSTTPEEL-AEKARQFDLASPASFEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVH--REYHVQFFGKVIQRAWVVSNAIMEYEGIEEFLLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQ--------------------LRNVTYDQPPVPRQRRTS---GSSTISTASRKRKRNTS----GGTVGSAVSEEEFPAKRG--------RFDMA---EELIQAIAPETLEAHRRKLKTGFKLFQLANLERIRRDSA--DHTEAERKLGKMWAGVSGMERKFYQEQ--ASNLGQSDPVDD---SQSSLQEDDDYVILDS------EDEAFNDEASVSSSVKSSKFVEPRQEKENRQPSEMIG------------VWK--------KEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHI-STPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNGAFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGKSKRSK----KKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHDTAVENHAELGNICDEHEDDFE 1543
            + ++  EV      E+L A  +  +DL  P  + EG MLWA+V G PYWPC V   P   ++TR+   +G V   R YHVQFFG  ++R WV   ++M +EG  +FL + +  +   KG+ +  P            + AW+ AV+ AE  + LS  ER LQ                    L+N   +  P  R+R +S    SS +   +++RK           V +  S + + AK           +D A   E L Q    E  ++ +  + +      + +      D      T    KL K+    S  +     EQ   +N     P      S+SSLQ +       S      E E   +E ++ S V +S     +  +E+   +E  G            ++K        K+  C ICE+      D+I+C   CG  FH +C+ ++    + + C EC +G HAC  CK    +  +CS   C +++H DC+R+  L   +R  +  FVCP+H C TCA DN K P      R  +CIRCPTAYH GD+C+ AG+  +  + ++C  H+ P    +  S    +N  WCF CSKGG+L+CCE CPA+FHAEC+ +  TP+  ++C  C  GR PLYG IVW+K+G YRWWP ++ HP  VP NI+   H++GEFP++F GS +Y+WI++GR FL+++GD     G+ S+GL   + +G+ EA E F  +T  K    A    + ++  + KP  Y  IK+N P G+  +   + S+   C+C  D    C   +DCLNR +M EC P+ CPA EKC NQRF KR YP+     +++RGWGL   ED+KKG F++EYVG+LI  +E + R++ +      +NFY +TMD +R+IDAGPKGN +RFMNHSC PN ETQKWTVNGD RVGLFA  DI   SELTFNY  E LG  K  C CG+ NCSGF+G +PK           K+  K +R K    +K  +D CFRC + G+L+MCD   CPKVYHL+CL   K P  KW CPWHHC  CGK+A   C+ CPN+YC  H        +  +IC +H D  E
Sbjct:  271 VLIMPAEVPTGPQLEKLKAMDSSTYDLQHPPLYTEGDMLWAKVSGHPYWPCMVAKCPFSKMFTRI---KGDVRIIRSYHVQFFGNEVERGWVNEPSLMLFEGKLKFLNQAQLEQQCKKGRSAYNPFK-----INITRRHAWNIAVDEAEGAMPLSKAERKLQYTFEYVFMDDLKKDQLNKKELKNTVKESKPAKRKRTSSEGVDSSPLLNKNKRRKLEVKFPPKSTPVKAEFSFDTYYAKHRSTVIEKHPEWDTAFVFEYLRQQWEKEKRKSPKLAVPSPLPQASMPSTPATPSDQGGLKRTRTPSKLIKLLTAESAAKASLLSEQPVKNNASPGPPRKRGRPSKSSLQSEPAIATSSSPRPSTPEMEDAPEEETMCSKVAASALSARKASQESDSSTESKGKGLRENEPYELEIFKLNTTCKIDKDKICAICEK----NGDVIECSKTCGQHFHPACVNVDAQAMNQYVCTECTTGIHACFSCKNKDMETVKCSVNMCNKYYHEDCIRKYRL---TRWENKGFVCPLHTCATCAVDNVKNPK-SIKGRFFRCIRCPTAYHVGDFCIAAGSQNLAGTYMLCSDHFQP---NRSLSCHSRLNITWCFSCSKGGTLLCCETCPAAFHAECVKVEKTPEEAWFCMDCAAGRKPLYGNIVWIKVGNYRWWPGEICHPRHVPLNIQEKAHQVGEFPVRFFGSHDYYWIHRGRVFLFQEGDKGSKEGS-SRGLFKIYMKGVNEATEAFKLWTAAK----AKKVEQEQERSDKKPAPYKFIKSNVPIGNVQICKAELSEIPRCECKPDQEDAC--TTDCLNRMMMYECHPTVCPAGEKCHNQRFQKRQYPECEPFKSESRGWGLRCLEDIKKGQFVLEYVGDLIDEEECKRRIEQAH-EDNITNFYMLTMDKNRIIDAGPKGNFSRFMNHSCCPNLETQKWTVNGDIRVGLFALCDIPKGSELTFNYNLECLGNEKKACACGSDNCSGFLGVRPKTAAATANEKKAKELKKKRRKKKLDPRKEHDDDCFRCGEGGELVMCDKGNCPKVYHLQCLKLTKPPSGKWLCPWHHCDECGKMASVKCVECPNSYCNAHLIGNIFKVDGLDICCDHTDIIE 1351          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|148705490|gb|EDL37437.1| (mCG16344 [Mus musculus])

HSP 1 Score: 703.745 bits (1815), Expect = 0.000e+0
Identity = 403/1071 (37.63%), Postives = 582/1071 (54.34%), Query Frame = 0

Query:  547 FEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSAVS-----EEEFPAKRGRFDMAEELIQ----------AIAPETLEAH---------RRKLKTG-------------FKLFQLANLERIRRDSADHT--EAERKLGKMWAGVSGMERKFYQEQASNLGQSDPVDDSQSS--------LQEDDDYVILDSEDEAFNDEASVSSSVKSSKFVEPRQEKENRQP-----------------SEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGN------GLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHD--TAVENHAELGNICDEHE 1539
            +  G ++W++V G P+WPC V  DP L  +T++  ++    R+YHVQFFG   +RAW+   +++ +EG E+F  L +  A +   K +K KL  LK   I G++ +A W+  +  AE+  S+S +ER  +     Y    +    + +  + I T       ++SG +  +AV      EE+ P KR R        +          +  P+  EA           RK  TG             F +F   + + +  +  D +  E E  LG  W+ ++  ++  Y  + S +  +   +DS +         L++ +      S    FN  +S S+S+   +  +   ++ +  P                 SE     KKE+ C +CE+       L+ C+G C  +FH +CL +    +  + C ECASG H+C +CK    +V RC    CG+F+H  C+++   +P +      F CP+H C +C + NP  P      ++++C+RCP AYH GD C+ AG   I S+ I+C  H+T     K      HVN +WCF+CSKGGSL+CCE CPA+FH +CL+I  PDG ++C+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   FN     ++ RE        Q    KPP Y  IK N+P+G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E C NQ FTKR YP+  +  T  +GWGLV   D++KG+F+ EYVGELI  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK   +++          K ++ ++K   K+  ED CFRC D GQL++CD K C K YHL CLG  K P  KW CPWHHC  CGK + ++C  CPN++CK H   TA  +  +  + C EH+
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSA-RQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKL--LKP--ISGRL-RAQWEMGIVQAEEAASMSIEERKAKF-TFLYVGDQLHLNPQVAKEAGIVTEPLGEMVDSSGASEEAAVDPGSVREEDIPTKRRRRTKRSSSAENQEGDPGTDKSTPPKMAEAEPKRGVGSPAGRKKSTGSAPRSRKGDSAAQFLVFCQKHRDEVVAEHPDASGEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTEHEVSDSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKT----GSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCMSCHASNPSNPRPS-KGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---RKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARET-------QESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHD 1260          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|719768443|ref|XP_010218385.1| (PREDICTED: histone-lysine N-methyltransferase NSD2 [Tinamus guttatus])

HSP 1 Score: 700.279 bits (1806), Expect = 0.000e+0
Identity = 393/1015 (38.72%), Postives = 560/1015 (55.17%), Query Frame = 0

Query:  550 GCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF-LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSAVSEEEFPAKRGRFDMAEELIQAIAPETLEAHRRKLKTGFKLFQLANLERIRRDSADHTEAERKLGKMWAGVSGMERKFYQEQASNLGQSDPVDDSQSSLQEDDDYVILDSEDEAFNDEASVSSSVKSSKFVEPRQEKENRQP-----------------SEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDG------KNVNGNGLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTH-DTAVENHAELGNIC 1535
            G ++W++V G P+WPC V  DP L  YT++  ++    R+YHVQFFG   +RAW+   +++ ++  ++F  L  E+ K  L    +K   +K    +   +    +E +E     LS   + R     N  +     P+    SGSS  +    KRK         S         KR +    +E  +    E  E  R++L+       +      +R++++   A+    K+    S  +         N   +  + D+   L++ +     +S   AF+  +S S+S+  ++  + + ++ +  P                 SE     KKE+ C +CE+      DL+ C+G+C  +FH SCL +       + C+EC SG H C +CK    DV RC  + CG+F+H  C+++  L   +   +  F CP+H C +C   NP  P +    ++++C+RCP AYH+GD C+ AG   I S+ IVC  H+T    TK  +   HVN +WCF+CSKGGSL+CCE CPA+FH +CL+I  PDG +YC+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   F      K  REA  T ++ +    KPP Y  IK N+P G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E+C NQ FTKR YP+  +  T  +GWGLV   D+KKG+F+ EYVGELI  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK+       +       + ++ + K   KK  ED CFRC D GQL++CD K+C K YHL CLG  K P  KW CPWHHC  CGK +V++C  CPN++CK H D  V N    G +C
Sbjct:  224 GDLVWSKVSGFPWWPCMVSADPVLHSYTKLKGQKKSF-RQYHVQFFGDAPERAWIFEKSLVPFKEKDQFEQLCQESAKQAL----TKAEKIKVVAEHPDASSDEIEELLESQWNMLSEKQKARY----NTKFAIVTSPKSEEDSGSSLKNIGEAKRKVFQDSPKRRSRSRSNLHGNKRNQKKRTKEPTEDF--EVQEPPRKRLR-------MDKQNNRKRETSNDKTAKTNSTKVTETSSSQK---------NQSATKNLSDACKPLKKRNRASAAESSTLAFSKSSSPSASLTENEISDGQGDERSESPYESADETQTEVSISSKKSERGAGTKKEYVCQLCEKT----GDLLLCEGLCYRAFHVSCLGLSGRPSGKFICSECTSGVHTCFVCKEPKADVKRCVVSHCGKFYHEACVKKFHL---TVFENRGFRCPLHSCLSCHVSNPSHPRVS-KGKMMRCVRCPVAYHAGDVCIAAGCAVIASNSIVCTNHFT---ATKGKTHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWYCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGIKGIGKVFKNALQEAEARFREI---KLQREAKETQESER----KPPPYKHIKVNKPCGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMYECHPQVCPAGERCQNQCFTKRQYPETQIIKTDGKGWGLVAKRDIKKGEFVNEYVGELIDEEECMARIKYAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCKCGAPNCSGFLGDRPKNSSTNASEEKGKKTKKRTRRRRMKNEGKKESEDDCFRCGDGGQLVLCDRKSCTKAYHLSCLGLVKRPFGKWECPWHHCDVCGKPSVSFCHFCPNSFCKEHQDGTVLNSMLNGQLC 1188          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|675650462|ref|XP_008991959.1| (PREDICTED: histone-lysine N-methyltransferase NSD2 isoform X2 [Callithrix jacchus])

HSP 1 Score: 700.279 bits (1806), Expect = 0.000e+0
Identity = 407/1072 (37.97%), Postives = 579/1072 (54.01%), Query Frame = 0

Query:  547 FEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSA-----VSEEEFPAKRGR----------FDMAEELIQAIAPETLEAHRRK-----------------LKTGFKLFQLANLERIRRDS--ADHTEA-----ERKLGKMWAGVSGMERKFY------------QEQASNLG---------QSDPVDDSQSSLQEDDDYVILDSEDEAFNDEASVSSSVKSSKFVEPRQEKENR-----QPSEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGN------GLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHD--TAVENHAELGNICDEHE 1539
            +  G ++W++V G P+WPC V  DP L  YT++  ++    R+YHVQFFG   +RAW+   +++ +EG  +F  L +  A +   K +K KL  LK   I GK+ +A W+  +  AE+  S+S +ER  +     Y    +    + +  + I+  S      +SG +  +A     V EE  P KR R           +   +++++   +T EA  R+                  + G    Q     +  RD   A+H +A     E  L   W+ +S  +R  Y            +E + N+            DP +D ++   ED     L ++  +    +       S    E   E +       + SE     KKE+ C +CE+   P S L+ C+G C  +FH +CL +    +  + C+ECASG H+C +CK    DV RC    CG+F+H  C+++   +P +      F CP+H C +C + NP  P      ++++C+RCP AYHSGD C+ AG   I S+ I+C  H+T     K      HVN +WCF+CSKGGSL+CCE CPA+FH +CL+I  PDG ++C+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   F      ++ RE        Q    KPP Y  IK N+P+G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E C NQ FTKR YP+  +  T  +GWGLV   D++KG+F+ EYVGE+I  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK    ++          K ++ ++K   K+  ED CFRC D GQL++CD K C K YHL CLG  K P  KW CPWHHC  CGK + ++C  CPN++CK H   TA     +  + C EH+
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSA-RQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKL--LKP--ISGKL-RAQWEMGIVQAEEAASMSVEERKAKF-TFLYVGDQLHLNPQVAKEAGIAAESSGEMAESSGVSEEAAENSKSVREEGIPMKRRRRAKQCSSAETLESEPDVVKSTPQKTAEADPRRGVGSPPGRKKATVSTPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNINGKKRNHPKRTQDPTEDLEA---EDTPRKRLRTDKHSLRKVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEK---PGS-LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKENKTDVKRCVVTQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCVSCHASNPSNPRPS-KGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA---RKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGVRGIGRVFKNALQEAEARFREIKLQREARET-------QESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGEVIDEEECMARIKHAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1258          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|149047443|gb|EDM00113.1| (similar to Wolf-Hirschhorn syndrome candidate 1 protein isoform 3 (predicted) [Rattus norvegicus])

HSP 1 Score: 699.508 bits (1804), Expect = 0.000e+0
Identity = 406/1086 (37.38%), Postives = 583/1086 (53.68%), Query Frame = 0

Query:  547 FEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTY-DQPPV-PRQRRTSGSSTISTASRKRKRNTSGGTVGSAVSEEEFPAKRGRFDMAEELI------------------------QAIAPETLEAH---------RRKLKTG-------------FKLFQLANLERIRRDSADHTEAERK--LGKMWAGVSGMERKFYQEQASNLGQSDPVDDSQSS--------LQEDDDYVILDSEDEAFNDEASVSSSVKSSKFVEPRQEKENRQP-----------------SEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNV----------NGNGLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHD--TAVENHAELGNICDEHE 1539
            +  G ++W++V G P+WPC V  DP L  +T++  ++    R+YHVQFFG   +RAW+   +++ +EG E+F  L +  A +   K +K KL  LK   I G++ +A W+  +  AE+  S+S +ER  +   +   DQ  + P+  + +G +T             G  V S+V+ EE     G   M EE I                        ++  P+  +A           RK  TG             F +F   + + +  +  D +E E +  LG  W+ ++  ++  Y  + S +  +   +DS +         L++ +      S    FN  +S S+S+  ++  +   ++ +  P                 SE     KKE+ C +CE+       L+ C+G C  +FH +CL +    +  + C ECASG H+C +CK    +V RC    CG+F+H  C+++   +P +      F CP+H C +C + NP  P      ++++C+RCP AYH GD C+ AG   I S+ I+C  H+T     K      HVN +WCF+CSKGGSL+CCE CPA+FH +CL I  PDG ++C+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   FN     ++ RE        Q    KPP Y  IK N+P+G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E C NQ FTKR YP+  +  T  +GWGLV   D++KG+F+ EYVGELI  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK   ++               ++ KG+ KR      ED CFRC D GQL++CD K C K YHL CLG  K P  KW CPWHHC  CGK + ++C  CPN++CK H   TA  +  +  + C EH+
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSA-RQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKL--LKP--ISGRL-RAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLRLNPQVAKEAGIAT----------EPLGEMVDSSVANEEAAVDPG--TMREEDIPVKRRRRAKRSSSAENQEGDPGTEKSTPPKMADAEPKRGVGSPAGRKRSTGSASRSRKGDSAAQFLVFCQKHRDEVVAEHPDASEEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTENEVSDNPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKT----GSLLLCEGPCCGAFHLACLGLSQRPEGRFTCTECASGIHSCFVCKESKMEVKRCMVNQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCMSCHASNPSNPRPS-KGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---RKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLSIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGVRGIGRVFKNALQEAEARFNEIKLQREARET-------QESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTSLSSEEKSKKAKKKTRRRRAKGEGKRQS----EDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHD 1260          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|795593635|ref|XP_011914637.1| (PREDICTED: histone-lysine N-methyltransferase NSD2 isoform X2 [Cercocebus atys])

HSP 1 Score: 699.508 bits (1804), Expect = 0.000e+0
Identity = 405/1069 (37.89%), Postives = 576/1069 (53.88%), Query Frame = 0

Query:  547 FEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQER-----VLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSAVSEEEFPAKRGR----------FDMAEELIQAIAPETLEAHRR-----------------KLKTGFKLFQLANLERIRRDS--ADHTEA-----ERKLGKMWAGVSGMERKFYQEQASNLGQSDPVDDS-----------QSSLQEDDDYVILDSEDEAFNDEASVSSSVKSSKFVEPRQE------------KENRQPSEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGN------GLKKKKGKSKRSKKKVWEDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHD--TAVENHAELGNICDEHE 1539
            +  G ++W++V G P+WPC V  DP L  YT++  ++    R+YHVQFFG   +RAW+   +++ +EG  +F  L +  A +   K +K KL  LK   I GK+ +A W+  +  AE+  S+S +ER      L + +  +  P V ++   +  S    A        +     SA  EE  P KR R           +   +++++   +T EA  R                 + + G    Q     +  RD   A+H +A     E  L   W+ +S  +R  Y  + + +      +DS           + +    +D  + D+  +    +      V  S   EP +               + + SE     KKE+ C +CE+   P S L+ C+G C  +FH +CL +    +  + C+ECASG H+C +CK    DV RC    CG+F+H  C+++   +P +      F CP+H C +C + NP  P      ++++C+RCP AYHSGD C+ AG   I S+ I+C  H+T     K      HVN +WCF+CSKGGSL+CCE CPA+FH +CL+I  PDG ++C+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   F      ++ RE        Q    KPP Y  IK N+P+G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E C NQ FTKR YP+  +  T  +GWGLV   D++KG+F+ EYVGELI  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK    ++          K ++ ++K   K+  ED CFRC D GQL++CD K C K YHL CLG  K P  KW CPWHHC  CGK + ++C  CPN++CK H   TA     +  + C EH+
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSA-RQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKL--LKP--ISGKL-RAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESFGEMAESSGVGEEAAENPKSA-REEGVPMKRRRRAKLCSSAETLESDPDVVKSTPQKTAEADPRRGVASPPGRKKTTASTPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNVKKRNHTKRTQDPTEDVEVEDTPRKRLRTDKHSLRKVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEK---PGS-LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCVSCHASNPSNPRPS-KGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFT---ARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGVRGIGRVFKNALQEAEARFREIKLQREARET-------QESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSATLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHFCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1258          

BLAST of histone-lysine n- h3 lysine-36 and h4 lysine-20 specific vs. nr
Match: gi|1212392298|ref|XP_021522661.1| (histone-lysine N-methyltransferase NSD2 isoform X2 [Aotus nancymaae])

HSP 1 Score: 698.738 bits (1802), Expect = 0.000e+0
Identity = 402/1069 (37.61%), Postives = 576/1069 (53.88%), Query Frame = 0

Query:  547 FEEGCMLWARVGGAPYWPCAVINDPDLGIYTRVSHRRGYVHREYHVQFFGKVIQRAWVVSNAIMEYEGIEEF--LLKTEAVKNDLKGKKSKLPALKAYCIYGKVAKAAWDEAVEGAEKTLSLSSQERVLQLRNVTYDQPPVPRQRRTSGSSTISTASRKRKRNTSGGTVGSA-----VSEEEFPAKRGR----------FDMAEELIQAIAPETLEAHRRK----------------------LKTGFKLFQLANLERIRRDSADHT--EAERKLGKMWAGVSGMERKFYQEQASNLGQSDPVDDS-----------QSSLQEDDDYVILDSEDEAFNDEASVSSSVKSSKFVEPRQE------------KENRQPSEMIGVWKKEHCCIICEEVTNPKSDLIKCKGMCGHSFHESCLQIETTNKDDWKCAECASGNHACQICKGYGQDVSRCSGAGCGRFFHVDCLRRADLWPQSRLSDTKFVCPVHMCHTCASDNPKEPMMKYNSRLLKCIRCPTAYHSGDYCVTAGTVQITSSQIVCPKHYTPPPPTKKSSGSLHVNTNWCFLCSKGGSLICCEKCPASFHAECLHISTPDGVFYCDSCEVGRMPLYGEIVWVKLGIYRWWPAKVLHPSEVPANIENLPHEMGEFPIQFCGSKEYFWINQGRCFLYEDGDVDKIPGNNSKGLNG---AFKRGLQEALEVFNAYTKDKDLREASSTVKARQVKNLKPPMYTKIKTNRPFGDCPVYTEDASD-KTCDCDTDNSSPCGPDSDCLNRYLMVECRPSSCPAKEKCLNQRFTKRIYPKLSVGLTQARGWGLVVGEDVKKGDFIIEYVGELITNDEFQTRLQTSLIRKEESNFYYMTMDNHRMIDAGPKGNIARFMNHSCDPNCETQKWTVNGDTRVGLFAKEDIKVNSELTFNYQFEALGEVKTKCLCGAHNCSGFIGEKPKDGKNVNGNGLKKKKGKSKRSKKKVW------EDLCFRCMDDGQLLMCDYKTCPKVYHLECLGREKMPREKWFCPWHHCVHCGKLAVNYCMHCPNAYCKTHD--TAVENHAELGNICDEHE 1539
            +  G ++W++V G P+WPC V  DP L  YT++  ++    R+YHVQFFG   +RAW+   +++ +EG  +F  L +  A +   K +K KL  LK   I GK+ +A W+  +  AE+  S+S +ER  +     Y    +    + +  + I+  S      +SG +  +A     V EE  P KR R           +   +++++   +T EA  R+                        + F +F   + + +  +  D +  E E  L   W+ +S  +R  Y  + + +      +DS           + +    +D+   D+  +    +      V  S   EP +               + + SE     KKE+ C +CE+   P S L+ C+G C  +FH +CL +    +  + C+ECASG H+C +CK    DV RC    CG+F+H  C+++   +P +      F CP+H C +C + NP  P      ++++C+RCP AYHSGD C+ AG   I S+ I+C  H+T     K      HVN +WCF+CSKGGSL+CCE CPA+FH +CL+I  PDG ++C+ C  G+   + +I+WVKLG YRWWPA+V HP  VP NI+ + HE+GEFP+ F GSK+Y+W +Q R F Y +GD     G+  +G+ G    FK  LQEA   F      ++ RE        Q    KPP Y  IK N+P+G   +YT D S+   C+C   + +PCG DS+CLNR LM EC P  CPA E C NQ FTKR YP+  +  T  +GWGLV   D++KG+F+ EYVGE+I  +E   R++ +    + ++FY +T+D  R+IDAGPKGN +RFMNHSC PNCET KWTVNGDTRVGLFA  DI   +ELTFNY  + LG  KT C CGA NCSGF+G++PK    ++     KK  K  R ++         ED CFRC D GQL++CD K C K YHL CLG  K P  KW CPWHHC  CGK + ++C  CPN++CK H   TA     +  + C EH+
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSA-RQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKL--LKP--ISGKL-RAQWEMGIVQAEEAASMSVEERKAKF-TFLYVGDQLHLNPQVAKEAGIAAESSGEMAESSGVSEEAAENPKSVREEGIPMKRRRRAKLCSSVETLESEPDIVKSTPQKTAEADPRRGVGSPPGRKKATVSTPRSRKGDAASQFLVFCQKHRDEVVTEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNISGKKRNHTKRTQDPTEDFEAEDAPRKRLRTDKHSLRKVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEK---PGS-LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKENKTDVKRCVVTQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCVSCHASNPSNPRPS-KGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA---RKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDR----GSRYQGVRGIGRVFKNALQEAEARFREIKLQREARET-------QESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGEVIDEEECMARIKHAH-ENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKPKKKSRRRRARGEGRRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1258