Query:   13 KEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLSKNPQG 576
            KEIP II D +  K+Y++G+FLGKGGFAKCYEL DM + E++AGKIVPKSLL K HQREKM+QEI L K   H Y+VKL+SYFED +FVYIILELCRRRSLMELHKRRKA+TEPETRYFMNQIL GC YLH++K+IHRDLKLGNIFLNDDM++K+GDFGLAT+VD+ GERKRTLCGTPNYIAPEVL KKGHSYEVDVWSLGCI+YTLLVG+PPFET TLK+TY+RIK NEY VPS VGPLA+NLI +LLQ +PS+RP + EIL+D+FMT  Y+PHRLP SCLTM PRFD   N++++A+RGPLTELNT+   + L     KK  +G  N    ++ +L +L KQL  VI ++P+ +    EDEAEDPK  PMV VSKWVDYSDKYGFGY+LSD+SIGV+FND+T+LLLLS+GSNIHYID+ G EHYYT+  FP+ +EKKVKLLNYFR YMKEHLLKAGA+IE REGDELSRIP +KTWFRTSRAVVM L+NGT+QINFFKDHTKIILCP+++A TYIDE +  RTFRFDLI+++G  QELASRLTYA+DK+ ++I     NP+G
Sbjct:   16 KEIPMIIVDSSSKKQYQKGRFLGKGGFAKCYELTDMASGEVVAGKIVPKSLLTKQHQREKMSQEIRLQKTFNHTYIVKLYSYFEDSNFVYIILELCRRRSLMELHKRRKAITEPETRYFMNQILQGCLYLHENKVIHRDLKLGNIFLNDDMEVKIGDFGLATKVDYFGERKRTLCGTPNYIAPEVLAKKGHSYEVDVWSLGCIMYTLLVGKPPFETQTLKDTYARIKKNEYHVPSRVGPLAKNLITKLLQSDPSKRPAVAEILKDEFMTMAYMPHRLPPSCLTMAPRFDANPNLSIVARRGPLTELNTE--PSALIPTAGKKDVNGRGNA---SDCYLGELHKQLASVIASQPASKTPCLEDEAEDPKVSPMVLVSKWVDYSDKYGFGYSLSDDSIGVVFNDLTKLLLLSNGSNIHYIDYGGVEHYYTIQEFPSAVEKKVKLLNYFRAYMKEHLLKAGADIEVREGDELSRIPFMKTWFRTSRAVVMHLTNGTVQINFFKDHTKIILCPMVAAVTYIDEQRRTRTFRFDLIERYGXSQELASRLTYAYDKIEALI----NNPKG 570          

Query:   16 PEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLL-VKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFD-----GERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVP-STVGPLARNLIGRLLQHEPSRRPNINE------ILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNA----CLTSDGMKKPSSGSDNG-------------QLNTENFLVDLQKQLKEVIDT-KPSLRNVINEDEAEDPKSLPM--VWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLT-----NFPTTLEKKVKLLNYFRNYMKEHLL----KAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIIL 519
            P  I DP+R   Y+RG  LGKGGFAK YE+++   K + A K++ +  L +K   + K+ +EI LHK L H  +V+    F+D  + +I+LE C  +SL  L + RKA+TE E RY++ QI  G +Y+H  +I+HRDLKLGN+FL  +  +K+GDFGLA ++D       G+ K +LCGTPNYIAPEVL K GH    D+W++GC+ Y +L G PPFET +L  TY++I +N Y +P  ++     + I +LL   P  R  +++      +L++ F  KG+LP  LP S +   P+F  +       Q       NT   +A    C+  +   K +S                   LN+   L      L E +D  +  +R+     + E P  +    V+V+KW+DYS+K+GFGY LSD ++G   ND T +    +     Y ++   E  +T       +    L  +V LL+Y   YM + L      A A   T      + IP +  W+RT R +VM L+N ++QINF ++HTKI+L
Sbjct:   11 PPQIMDPSRNVPYQRGPLLGKGGFAKVYEVREPHGK-VYADKMIRRDFLELKQGSKAKVEREIRLHKELKHQNIVRFIHTFQDSLYCHILLEKCNLKSLFHLVRFRKALTETEVRYYVKQICDGVRYIHSKEILHRDLKLGNMFLTREYTVKIGDFGLAIKMDSSSLRDYGKSKFSLCGTPNYIAPEVLAKLGHHMAADIWAVGCMTYAMLFGSPPFETKSLSRTYAKIASNNYTIPKKSISLHTHSFIKKLLDPHPELRGQLHQPGQNQDLLQEPFFKKGFLPCTLPNSAMACPPKFSVEA-----LQGKDYFHQNTHTEDAIPPGCVPGNLKLKIASIFQQSVTSSNSSANSSSSSLNSPTILTSSSAILSETVDNLRQCVRSSFMGKDLEFPSPVEFIPVFVTKWIDYSNKHGFGYRLSDGAVGAFLNDNTHISYCEEEEKRLY-EYSDVERSFTFNMDGXRSXTPDLLSRVHLLDYLSRYMAKKLACANPSAFATQVTVTTRSTTTIPHIVKWWRTPRFLVMILNNTSIQINFIQEHTKIVL 549          

Query:   28 YERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRR--KAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTK 282
            ++ G+ LGKG F   Y  ++  +K I+A K++ K+ L K +   ++ +EI +   L H ++++L+ YF D+  VY+ILE   +  L +L K    K   E     ++ Q+     YLH  K+IHRD+K  N+ L+    +K+ DFG +  V     R+ T+CGT +Y++PE++  + H  +VD+WSLG + +  LVG+PPFET   +ETY +I N + + PS + P AR+LI +LLQ  P RR  + E++   ++ K
Sbjct:   53 FDIGRPLGKGKFGNVYLAREKKSKFIVALKVMFKNQLKKANVEHQLRREIEIQXHLRHPHILRLYGYFYDETRVYLILEFASKGELYKLLKNEPLKRFEETLAARYIYQMSGALDYLHSKKVIHRDIKPENLLLDSKGNLKIADFGWS--VHAPSSRRGTMCGTLDYLSPEMIEGRSHDEKVDLWSLGILCFEFLVGKPPFETDNQQETYKKITNVDIEWPSFISPEARDLISKLLQKIPERRLPLKEVIVHPWIMK 307          

Query:   27 RYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLM-ELHKRR-KAVTEPET-RYF--------------MNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYE-VDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFM 280
            RYE    LG+GGF K Y   D + +++    +    LL  PH +E++ +E+ +H  L H  ++   + F+D   VYIILE C    L   L K R KA    +  R+F              + QIL G +YLH + I+HRDL L N  L+    +K+GDFGLAT++    E   T+CGTP  IAPE++ +     E  DVW LGCILYTLLVG  PFET  ++ T  ++   E + PS++   A++L+ R+L+  PS R ++ +I    F+
Sbjct:   11 RYEILSLLGQGGFGKVYRALDENGQDVAIKALDISILLRTPHLKERVNEEVRIHSKLNHNSILSFKNVFQDSTHVYIILEYCPHGDLAAHLRKNRGKAFAAQDCLRWFRQYSSFNPLSSILIIQQILSGIEYLHRNLIVHRDLTLANCLLDSGYNVKIGDFGLATQLRAKNEVHNTMCGTPISIAPEIVSRVPSDPEPADVWGLGCILYTLLVGTSPFETEGIRSTMRKVVCEEPEFPSSLSVEAKDLLSRMLKKNPSLRISLKDIGNHPFI 282          

Query:   27 RYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLME---LHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVL-GKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGY-----LPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRN 324
            +Y   K +GKG FAK    +   T + +A KI+ K+ L  P   +K+ +E+ + K L H  +VKLF   E +  +Y+++E      + +   LH R K   E E R    QI+   +Y H  KIIHRDLK  N+ L+ +M IK+ DFG +      G +  T CG+P Y APE+  GKK    EVDVWSLG ILYTL+ G  PF+  TL+E   R+   +Y++P  +     NL+ + L   P RR ++  I+RD +M  GY     LP + P   +  T R D    M    Q     E+ + +RN
Sbjct:  118 KYRLLKTIGKGNFAKVKLARHTATGKEVAIKIIDKTQL-NPGSLQKLFREVRIMKTLDHPNIVKLFQVIETEKTLYLVMEYASGGEVFDYLVLHGRMK---EKEARAKFRQIVSAVQYCHQKKIIHRDLKAENLLLDSEMNIKIADFGFSNEF-IPGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPVRRASLETIMRDKWMNMGYEDEELLPFKEPTLDINDTKRIDILVGMGYNRQ-----EVESSLRN 414          

Query:   28 YERGKFLGKGGFAKCYELKDMDTKEIMAGKIV-PKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQ---IKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPS----TVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTK----GYLPHRL-PVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKKPSSGSD-NGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITR---LLLLSDGSNIHYIDFEGHEHY--YTLTNF-PTTLEKKVKLLNYFRNYM 462
            YE  + LGKG F+         T    A KI+  K L  +  Q  K+ +E  + + L H  +V+L    +++++ Y++ +L     L E    R+  +E +  + + QIL    + H + ++HRDLK  N+ L    +   +KL DFGLA  V  D        GTP Y++PEVL K+ +   VD+W+ G ILY LLVG PPF        Y++IK   Y  PS    TV P A+NLI ++L   P++R   +E L+  ++ +      + HR   V CL    +F+ +  +     +G +       RN    S   K  S GS      ++   L D +K  K+++D   +   VI  D AED K L  V  S  +   +    G    D +I    N+I R   LLL + GS     DFE        +LT+F P  L   V+ L Y + Y 
Sbjct:   13 YELKEELGKGAFSVVRRCVQKSTGLDFASKIINTKKLSARDFQ--KLEREARICRKLQHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHSNGVVHRDLKPENLLLASKQKGAAVKLADFGLAIEVQGDQHAWFGFAGTPGYLSPEVLKKEPYGKAVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPAKRIRSDEALKHPWICQRERVASVVHRQETVDCL---KKFNARRKL-----KGAILTTMLVSRNFSTRSMASKGKSDGSQVKESTDSSTTLEDDEKDEKKIVDRSST---VIARDTAEDMK-LSHVKNSSSLQIRNSNSQG----DPNISARKNEIIRCTELLLEAIGSG----DFESFTRLCDSSLTSFDPEALGNLVEGLEYHKFYF 445          

Query:    9 DPNAKEIPEIIRD-PNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLME-LHKRRKA-VTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNE--YQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTK 282
            +P  K  P+   D P     +E G+ LGKG F   Y  ++  +K I+A KI+ KS L K     ++ +EI +   L    V++LF YF DD  +Y+ILE   R  L + L  +  A   E     ++ Q+     Y     +IHRD+K  N+ L+    +K+ DFG +  V   G R+ T+CGT +Y+ PE++  + +   +D+WSLG +++  LVGRPPFE  T +ETY RI   +  +  P+ +G  AR+LI  LL+ +P++R  + ++L   ++ +
Sbjct:    3 NPFGKNYPKGSADNPWHLSDFEIGRPLGKGKFGNVYMAREKKSKYIVALKILFKSQLQKNSVEHQLRREIEIQTHLRSPRVLRLFGYFWDDSKIYLILEFAARGELYKTLQNQPNARFAESTAAKYIKQMTEALIYCQSMNVIHRDIKPENLLLDLKGDLKIADFGWS--VHAPGNRRGTMCGTLDYLPPEMINGEKYDKTLDLWSLGVLMFEFLVGRPPFECKTQQETYKRIAKVDIMWPDPNFIGLDARDLIRSLLRIKPTQRIPLEQVLEHPWILR 279          

Query:   24 RPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRR 268
            R + +E  + +G G FA+   +K   T    A KI+    +V+  Q E +  E  +   L H Y+V L   ++D  F+Y++        L    +       P + +++++I+   +YLH   I++RDLK  N+ L+ D  +K+ DFG A R+    +R  TLCGTP Y+APE++  KGH+  VD WSLG ++Y +L G PPF        Y +I   +   P  + P+ ++LI +LL  + ++R
Sbjct:   43 RLEDFELRETIGTGTFARVCLVKHKFTHAYYALKILSIKDVVRLKQVEHVKNETNILSELRHPYIVNLVWKYKDPKFLYMVFPYISGGELFSYLRTAGRFNVPTSLFYISEIVCALEYLHSQSIVYRDLKPENLLLDRDGHLKITDFGFAKRI---SDRTWTLCGTPEYLAPEIIQSKGHNRAVDWWSLGILIYEMLAGYPPFFDDNPFGIYEKILGGKIDWPRQMEPVTKDLIKKLLVQDRTKR 284          

Query:   28 YERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVL-GKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLP 290
            Y  G+ LG G F K        T   +A KI+ +  +       K+ +EI   K   H +++KL+        +++++E      L +   +   + E E R F  QI+ G +Y H   ++HRDLK  N+ L+  + +K+ DFGL+  +  DGE  RT CG+PNY APEV+ GK     EVD+WS G ILY LL G  PF+   +   + +IK+  + +P  +   A +L+  +LQ +P +R  ++EI + ++  K    +  P
Sbjct:   24 YVLGETLGIGTFGKVKVGFHQITGHKVAVKILNRQKIKNLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPTDIFMVMEHVAGGELFDYIVKHGKLKENEARRFFQQIISGVEYCHRHNVVHRDLKPENLLLDGSLNVKIADFGLSNMM-MDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPALFRKIKSGVFPIPDYLNKKAVSLLCHMLQTDPMKRATVDEIRKHEWFMKDLPAYLFP 286          

Query:   28 YERGKFLGKGGFA----KCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLG-HLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVL-GKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGY 284
            Y+    LGKG F+      + L  +D    +A KIV K  L       KM +EI + + LG H +V++L    E    +Y++ E  +   + +    +  +TE +  ++  QIL    YLH   I+HRDLK  N+ L+ +M +KL DFG +      G    T CG+P Y APE+  GK+    + D+WSLG +LY L+ G  PF+  TL+E  SR+ + +Y+VP  +     +L+  LL  EP +R ++ +I    ++ K Y
Sbjct:   14 YDLSSTLGKGNFSVVRLGVHRLTGVD----VAVKIVDKDNL-DSENATKMEREIEILRSLGPHPHVIRLVEVMESGRAIYMVTEHAKNGEIFDFVAEKGRLTEGKAGHWFGQILSALDYLHSLGIVHRDLKAENLLLDQEMNVKLADFGFSNYYS-PGHLLSTWCGSPPYAAPELFEGKEYIGPKADIWSLGVVLYVLVSGSLPFDAPTLQELKSRVLSCQYRVPFFLSNECESLLKGLLVLEPEKRFSLKQIASHPWIKKNY 270          

Query:    5 ARTVDPNAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
            A T  P AKEIPE++ DP   +RY RG+FLGKGGFAKC+E+ D DTKE+ AGKIVPKSLL+KPHQ+EKM+ EI++H+ L H +VV    +FED+ FV+++LELCRRRSL+ELHKRRKA+TEPE RY++ QI+LGC+YLH +++IHRDLKLGN+FLN+D+++K+GDFGLAT+V++DGERK+TLCGTPNYIAPEVL KKGHS+EVDVWS+GCI+YTLLVG+PPFET  LKETY RIKNNEY +P  + P+A +LI ++LQ +P+ RP I+E+L D+F T GY+P RLP++CLT+ PRF    +    + R PLT LN  M N  +     +K            +  L D+ +QL  V  +KPS R ++ ++EAEDP  +P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL+L SDG ++ YI+ +G E Y T+++ P +L KK+ LL YFRNYM EHLLKAGANI  REGDEL+R+P L+TWFRT  A+++ LSNG +QINFF+DHTK+ILCPLM+A TYIDE ++ RT+R  L++++GC +ELASRL YA   V+ +++S S
Sbjct:   28 ASTAAPPAKEIPEVLVDPRSRRRYLRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHGNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKNNEYSIPKHINPVASSLIKKMLQPDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGMENP-MPERPREKEEPVVREASEPVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYSDGDSLQYIERDGSESYLTVSSHPNSLIKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGCVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCSKELASRLRYARAMVDKLLSSRS 593          

Query:    5 ARTVDPNAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLSKN 573
            A    P AKEIPE++ DP   ++Y RG+FLGKGGFAKC+E+ D DTKE+ AGKIVPKSLL+KPHQ+EKM+ EI++H+ L H +VV    +FED  FV+++LELCRRRSL+ELHKRRKA+TEPE RY++ QI+LGC+YLH +++IHRDLKLGN+FLN+D+++K+GDFGLAT+V+++GERK+TLCGTPNYIAPEVL KKGHS+EVDVWS+GCI+YTLLVG+PPFET  LKETY RIK NEY +P  + P+A +LI ++LQ +P+ RP I+E+L D+F T GY+P RLP++CLT+ PRF    +    + R PL  LN  + N  L     +K            E  L DL +QL  V  +KPS R ++ ++EAEDP  +P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL+L +DG ++ YI+ +G E Y T+++ P +L KK+ LLNYFRNYM EHLLKAGANI  REGDEL+R+P L+TWFRT  A+++ LSNGT+QINFF+DHTK+ILCPLM+A TYI+E ++ +T+R  L++++GC +ELASRL YA   V+ +++S S +
Sbjct:   30 APVAAPLAKEIPEVLVDPRSRRQYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSSRKPLKVLNKGVENP-LPDRPREKEEPVVRETNEAIECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSAS 597          

Query:   13 KEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
            KEIPE++ DP   ++Y RG+FLGKGGFAKC+E+ D DTKE+  GKIVPKSLL+KPHQ+EKM+ EI++H+ L H +VV    +FED  FV+++LELCRRRSL+ELHKRRKA+TEPE RY++ QI+LGC+YLH +++IHRDLKLGN+FLN+D+++K+GDFGLAT+V+++GERK+TLCGTPNYIAPEVL KKGHS+EVDVWS+GCI+YTLLVG+PPFET  LKETY RIK NEY +P  + P+A +LI ++LQ +P+ RP I+E+L D+F T GY+P RLP++CLT+ PRF    +    + R PLT LN  + N  L     +K            E  L DL +QL  V  +KPS R ++ ++EAEDP  +P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL+L +DG ++ YI+ +G E Y T+++ P +L KK+ LLNYFRNYM EHLLKAGANI  REGDEL+R+P L+TWFRT  A+++ LSNGT+QINFF+DHTK+ILCPLM+A TYI+E ++ RT+R  L++++GC +ELASRL YA   V+ +++S S
Sbjct:   38 KEIPEVLMDPRSRRQYVRGRFLGKGGFAKCFEISDSDTKEVFPGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHGFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGVENP-LPDRPREKEEPVVRETNEAIECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRS 595          

Query:   13 KEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLSKN 573
            KEIPE++ DP   +RY RG+FLGKGGFAKC+E+ D DTKE+ AGKIVPKSLL+KPHQREKM+ EI++H+ L H +VV    +FED+ FV+++LELCRRRSL+ELHKRRKA+TEPE RY++ QI+LGC+YLH +++IHRDLKLGN+FLN+D+++K+GDFGLAT+V++DGERK+TLCGTPNYIAPEVL KKGHS+EVDVWS+GCI+YTLLVG+PPFET  LKETY RIK NEY +P  + P+A +LI ++LQ +P+ RP INE+L D+F T GY+P RLP++CLT+ PRF    +    + R PLT LN  + N        K+     + G++  +  L D+ +QL  V  +KPS R ++ ++EAEDP  +P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL+L +DG ++ YI+ +G E Y T+++ P +L KK+ LL YFRNYM EHLLKAGANI  REGDEL+R+P L+TWFRT  A+++ LSNG++QINFF+DHTK+ILCPLM+A TYIDE ++ RT+R  L++++GC +ELASRL YA   V+ +++S S +
Sbjct:   38 KEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEV-VDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSAS 597          

Query:   11 NAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELN-------TDMRNACLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
            + KEIPEI+ DP   +RY RG+FLGKGGFAKCYE+ D++++E+ AGKIVPK++L+KPHQ++KMT EI + + L H +VV    +FED+ FVY++LELCRRRSL+ELHKRRKAVTEPE RY++ Q +LGC+YLH +++IHRDLKLGN+FLND+M++K+GDFGLAT+V++DGERK+TLCGTPNYIAPEVLGKKGHS+EVD+WS+GCI+YTLLVG+PPFET  LKETY RIK NEY VP  + P+A  LI ++L+ EP+ RP I+++L D+F T GY+P RLP +CLT+ PRF    +    + R PLT +N        + ++     + M++P S         + +L ++ +QL  V   KPS R VI ++EAEDP S+P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL++ +DG ++ YI+    E Y  + ++P  L KK+ LL YFRNYM EHLLKAGANI  REGDEL+R+P L+TWFRT  A+++ LSNGT+QINFF+DHTKIILCPLM+A +YIDE +   T++  LIQ+ GC +ELASRL YA   V  + +S S
Sbjct:   27 SVKEIPEILVDPRTRRRYLRGRFLGKGGFAKCYEITDLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEARYYLKQTILGCQYLHSNRVIHRDLKLGNLFLNDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSVPKHINPMATALIQKMLRSEPTSRPTIDDLLNDEFFTTGYIPSRLPTTCLTVPPRFSIAPSTIDQSLRKPLTAINKGQDSPLVEKQSVPAKEEEMQQPESTEP-----ADCYLSEMLQQLTCVNAVKPSERAVIRQEEAEDPASVPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNNSESYLNVRSYPAALTKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPFLRTWFRTRSAIILHLSNGTVQINFFQDHTKIILCPLMAAVSYIDEKREFHTYKLSLIQEFGCCKELASRLRYARTMVEKLQSSKS 589          

Query:   12 AKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELN-------TDMRNACLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
             KEIPEI+ DP   +RY RG+FLGKGGFAKCYE+ D++++E+ AGKIVPK++L+KPHQ++KMT EI + + L H +VV    +FED+ FVY++LELCRRRSL+ELHKRRKAVTEPE RY++ Q + GC+YLH +++IHRDLKLGN+FLND+M++K+GDFGLAT+V++DGERK+TLCGTPNYIAPEVLGKKGHS+EVD+WS+GCI+YTLLVG+PPFET  LKETY RIK NEY +P  + P+A  LI ++L+ +P+ RP I+++L D+F T GY+P RLP +CLT+ PRF    +    + R PLT +N        + + A    + M++P           + +L ++ +QL  +   KPS R +I ++EAEDP S+P+ W+SKWVDYSDKYG GY L D S+GVLFND TRL++ +DG ++ YI+    E Y  + ++PTTL KK+ LL YFRNYM EHLLKAGAN   REGDEL+R+P L+TWFRT  A+++ LSNGT+QINFF+DHTKIILCPLM+A +YIDE +  RT++  LIQ+ GC +ELASRL YA   V  + +S S
Sbjct:   28 VKEIPEILVDPRTRRRYLRGRFLGKGGFAKCYEITDLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEARYYLKQTISGCQYLHSNRVIHRDLKLGNLFLNDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSIPKHINPVAAALIQKMLRSDPTSRPTIDDLLNDEFFTSGYIPSRLPTTCLTVPPRFSIAPSTIDQSLRKPLTAINKGQDSPLVEKQVAPAKEEEMQQPEFTEP-----ADCYLSEMLQQLTCLNAVKPSERALIRQEEAEDPASIPIFWISKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNNTESYLNVRSYPTTLTKKITLLKYFRNYMSEHLLKAGANTTPREGDELARLPFLRTWFRTRSAIILHLSNGTVQINFFQDHTKIILCPLMAAVSYIDEKREFRTYKLSLIQEFGCCKELASRLRYARTMVEKLQSSKS 589          

Query:   12 AKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELN----TDMR-NACLTSDGMKKPSSGSDNGQLNTENFLVDLQ---KQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASL 570
            + +IP+ + D N+ K Y+R +F GKGGFAKCYE+ D++T ++ AGKIV K L++K +Q+EK  QEIT+H+ L H  +VK  +YFED   +YI+LELC++RS+MELHKRRK++TE E RY++ QI+ G KYLHD++IIHRDLKLGN+FLND + +K+GDFGLATR++++GERK+TLCGTPNYIAPE+L KKGHS+EVD+WS+GC++YTLLVG+PPFET TLK+TYS+IK  EY+VPS +   A +++  +LQ  P  RP I ++L  +F+    +P  LP SCLTM PR  +   +     R PL E+N     D R  +      +    + S     ++E++  D++   +QL  +I+ KP +      DE  DP + P+ W+SKWVDYSDKYGFGY L DE IGV+FND T+L+LL +  N+H+ID +G E Y T T++  +L+KK+KLL+YF+ YM EHL+KAGAN    E D++SR+P L +WFRT+ AVVM L+NG++Q+N F DH K+ILCP MSA TY+D++KN RT+RF  I ++G  ++L  ++ YA +K+  M+  +
Sbjct:    9 STDIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLN-FSDHMKLILCPRMSAITYMDQEKNFRTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLEKM 574          

Query:   14 EIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRF--DTKTNMNL-----IAQRGPLTELNTDMRNA---CLTSDGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEA-----EDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTL-TNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLSK 572
            ++P++I D  R  RYE+GKFLGKGGFA CYEL++  T E+ AGK+VPK+LL+K +QR+KM QE+ +H+ L H  VVKL+ +FED   VYI LELC RRSLMELHKRRKAVTEPE RYF  QI+ G  YLH+ KI+HRDLKLGN+FLND++Q+K+GDFGLAT  D D ERK+TLCGTPNYIAPEVL K GHS+EVD+W++GCILY LL G PPFE+ +L+ETYSRIKNN Y +P++    A  LI  LL   PSRRPN   + RD F   G++P RLPVSCLTM P    D     N+     I QRGP     + +       ++ +  ++ +   +  +  T+ +L +L  Q+ +++ T  +    I++ EA     + P++LP+ W+SKWVDYSDKYG GY L D S+GVLFND +R++L + G+ + YI+    EHY+ + +  P+ L+KK+ LL YFR+YM +HLL+AG  +  + GD+L+R+P+L+ WFRT  A+V+ LSNGT+QINFF DH K++LCPLM A T+IDE+K   T++F  + ++GC ++   R+ YA   +  ++   +K
Sbjct:   22 DVPDVILDGERKTRYEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLMELHKRRKAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDND-ERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPPFESKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFFKSGFMPARLPVSCLTMVPHLNDDEYAEENVSPSGTIDQRGPHQAGRSGLSAIPAHLVSRNSERQQTHRMEAYRQPTDCYLSNLLAQVNDLLATPTA---DIDDAEAALDSYQSPEALPVFWISKWVDYSDKYGIGYQLCDNSVGVLFNDNSRIMLDTAGTQLTYIEKTEKEHYFDMESAIPSGLQKKMTLLKYFRSYMNDHLLQAGQQVTRKVGDDLARLPTLRVWFRTKSAIVLHLSNGTVQINFFNDHIKMVLCPLMQAVTFIDENKRMFTYKFSHLAENGCPEKFLHRIQYAKCMIQRLVEEHTK 592          

Query:   14 EIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQE-ITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRF---DTKTNMNLIAQRGPLTELNTDMRN-ACLTSDGMKKPSSGSDNGQLNTE-----------NFLVDLQKQLKEVIDTK-PSLRNVINEDEA-----EDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTN--FPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIAS---LSKNPQGGP 578
            E+P +I D +R   YE+G+FLGKGGFA CYEL +  T+E++AGK+VPKS+LVK +QR+K+  E I +H+ LGH+ +VKLF++FED+  VYI LELC RRSLMELHKRRKAVTEPE RYF +QI+ G  YLHD  IIHRD+KLGN+FLNDD+ +K+GDFGLAT V+ D ERK+TLCGTPNYIAPEVL K GHS+EVD+W++GCILY LL G+PPFE+ +L+ETYSRI++N Y +PS     A +LI ++L  EP+RRP   ++ RD F   G++P RLPVSCLTM P+F   +T      +A RG        +   A L++      S+ +D  +   +            +L  L  Q+  +++ + P L     E+EA     + P+ LP+ W+SKWVDYSDKYG GY L D S+GVLFND +R++L   G+ + YI+    EHY+++ +   P  L KKV LL YFR+YM +HL+KAG   E R GD+L+R+P+L+ WFRT  A+V+ LSNGT+QINFF DH K+++CPLM A T+ID++K   T++ + +Q++GC ++   RL YA   +  +++    +S+NP   P
Sbjct:   24 EVPALIADKDRGTYYEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKVDNERILIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGD-ERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFFKSGFMPTRLPVSCLTMVPKFGGHETSMMEENVAPRGVDARSQRPLNGRAGLSALPQHIVSNNADRERAQQQAAEATFREPEDAYLSQLFHQVAVLLEQRIPGLE----EEEAALDGYQSPECLPVFWISKWVDYSDKYGIGYQLCDNSVGVLFNDNSRIMLDQAGNELTYIEKSNKEHYFSMHSGEMPGLLNKKVTLLKYFRSYMNDHLVKAGEGSEQRAGDDLARLPTLRVWFRTKSAIVLHLSNGTVQINFFNDHVKMMMCPLMQAVTFIDQNKRMLTYKLNNLQRNGCPEKFLHRLKYAKTMIERLMSDANVVSQNPARQP 610          

Query:   10 PNAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPV-SCLT---MTP-----RFDTKTNMNLIAQRGPLTELNTDMRN--ACLTSDGMK--------KPSS------------------GSDNGQLNTENFLVDLQKQLKEVIDTK-PSLRNVI------NEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILC---PLMSACTYIDEDKNHRTFRFDLIQKHGCGQE 551
            P   +   +I DP   + Y +G+ LGKGGFA+CYE  D +T    A K++P+S + KPHQREK+  EI LH+ L H ++V+   +FED   +YI LELC R+SL  + K R  + EPE RY++ QIL G KYLH   I+HRDLKLGN F+ D+M++K+GDFGLA R++   +RK+T+CGTPNY+APEVL ++GH  E DVWSLGC++YTLL G PPFET  LKETY  IK   Y +P+++   AR L+  +L+  P  RP+I +ILR DF TKGY P RLPV SC+T   +TP         K   +L  +R    + +++ ++  +CL S  M+        +P +                   S  G L +     +    +  V+++   +LRN +       ++ A   +  P+VWVSKWVDYS+K+GFGY LS   + VLFND T + L ++   +HY         +++ + P  L+ ++ +L YF +YM++HL+K G ++ + E  E+   P L  W +T +A++M  S+GT+Q+NF+ DHTK+IL    PL+   T++  +++  T+    +++ GC  +
Sbjct:   44 PQTPDASRLITDPRSGRTYIKGRLLGKGGFARCYEATDTETSIAYAVKVIPQSRVAKPHQREKIINEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKSLFGRRKSKNKNHSEEQDNVSCLVSGLMRTSIGHPDVRPEAPAASALAPVSLVETAAEDSSPRGTLASSGDGFEEGLTVTTVVESALCALRNCVAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGSVPRALQPQLGILRYFASYMEQHLMK-GGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLL--VTFVARNRSACTYLASHLRQLGCSPD 629          

Query:    1 MSSKARTVDPN-AKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTS---DGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIAS 569
            MSS+     P  AKEIP++I DP+  + YERGKFLGKGGFAKCYELKD  T EI+AGKIVPKS+L K HQ+EKM QEI LHK + H Y+VKLFSYFED +FVY+ILELCR++SLMELHKRR+A+TEPETRYFM Q+LLGC+YLH++KIIHRDLKLGN+FLNDD++IK+GDFGLAT+VDF+GERK+TLCGTPNYIAPEVL KKGHSYEVDVWSLGCILYTLLVG+PPFET +LK+TY+RIK NEY +PS +GPLARNLI +LLQ++P +RP++ EIL+DDFMT GYLP RLP SCL+M PRFD K N +LIA++ PL+E N    ++  T    DG+K   SG  +  L       +L   L++++++KP  R    E+EAEDP S P+VWVSKWVDYSDKYGFGY+L+D+SIGV+FND+T+LLLL+DG NIHYID++G EHY++LT +P T+EKKVKLLNYFRNYMKEHLLKAGAN+E R+ D LSRIPSLKTWFRTSRAVVM LSNGT+QINFFKDHTKIILCPL+ A TYID+ + +RTFRFDL++K+GC Q++A+RL YA+DK+++M+ S
Sbjct:    1 MSSRVPLETPVVAKEIPDVITDPSTKRTYERGKFLGKGGFAKCYELKDKATGEIVAGKIVPKSMLTKAHQKEKMAQEIRLHKIVRHSYIVKLFSYFEDSNFVYVILELCRKKSLMELHKRRQAITEPETRYFMRQMLLGCQYLHENKIIHRDLKLGNVFLNDDLEIKIGDFGLATKVDFEGERKKTLCGTPNYIAPEVLSKKGHSYEVDVWSLGCILYTLLVGKPPFETQSLKDTYNRIKRNEYHIPSKIGPLARNLIAKLLQNDPMKRPSVTEILKDDFMTMGYLPCRLPQSCLSMAPRFDNKLNASLIARKNPLSEYNRISESSSSTGEKKDGVKGSVSGPSDCHLG------ELFAMLRKLVESKPGSRVQAQEEEAEDPMSQPLVWVSKWVDYSDKYGFGYSLNDDSIGVVFNDLTKLLLLADGHNIHYIDYDGGEHYHSLTEYPETIEKKVKLLNYFRNYMKEHLLKAGANMEIRDEDVLSRIPSLKTWFRTSRAVVMHLSNGTIQINFFKDHTKIILCPLLGAVTYIDDTRRNRTFRFDLLEKYGCSQDIAARLNYAYDKIDAMMKS 567          

Query:    1 MSSKARTVDPN-AKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTS---DGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIAS 569
            MSS+     P  AKEIP++I DP+  + YERGKFLGKGGFAKCYELKD  T EI+AGKIVPKS+L K HQ+EKM QEI LHK + H Y+VKLFSYFED +FVY+ILELCR++SLMELHKRR+A+TEPETRYFM Q+LLGC+YLH++KIIHRDLKLGN+FLNDD++IK+GDFGLAT+VDF+GERK+TLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVG+PPFET +LK+TYSRIK NEY +PS +GPLARNLI +LLQ++P +RP++ EIL+DDFMT GYLP RLP SCL+M PRFD K N +LIA++ PL+E N    ++  T    DG+K   SG  +  L   + +      L++++++KP  R    E+EAEDP S P+VWVSKWVDYSDKYGFGY+L+D+SIGV+FND+T+LLLL+DG +IHYID++G EHY++LT +P T+EKKVKLLNYFRNYMKEHLLKAGAN+E R+ D LSRIPSLKTWFRTSRAVVM LSNGT+QINFFKDHTKIILCPL+ A TYID+ + +RTFRFDL++K+GC Q++A+RL YA+DK+ +M+ S
Sbjct:    1 MSSRVPLETPVVAKEIPDVITDPSTKRTYERGKFLGKGGFAKCYELKDKATGEIVAGKIVPKSMLTKAHQKEKMAQEIRLHKIVRHSYIVKLFSYFEDSNFVYVILELCRKKSLMELHKRRQAITEPETRYFMRQMLLGCQYLHENKIIHRDLKLGNVFLNDDLEIKIGDFGLATKVDFEGERKKTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGKPPFETQSLKDTYSRIKRNEYHIPSKIGPLARNLIAKLLQNDPMKRPSVTEILKDDFMTMGYLPCRLPQSCLSMAPRFDNKLNASLIARKNPLSEYNRISESSSSTGEKKDGVKGGLSGPSDCHLGENHAM------LRKLVESKPGSRVQAQEEEAEDPMSQPLVWVSKWVDYSDKYGFGYSLNDDSIGVVFNDLTKLLLLADGHSIHYIDYDGGEHYHSLTEYPETIEKKVKLLNYFRNYMKEHLLKAGANMEIRDEDVLSRIPSLKTWFRTSRAVVMHLSNGTIQINFFKDHTKIILCPLLGAVTYIDDTRRNRTFRFDLLEKYGCSQDIAARLNYAYDKIEAMMKS 567          

Query:    1 MSSKARTVDPN-AKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTS---DGMKKPSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIAS 569
            MSS+     P  AKEIP++I DP+  + YERGKFLGKGGFAKCYELKD  T EI+AGKIVPKS+L K HQ+EKM QEI LHK + H Y+VKLFSYFED +FVY+I+ELCR++SLMELHKRR+A+TEPETRYFM Q+LLGC+YLH++KIIHRDLKLGN+FLNDD++IK+GDFGLAT+VDF+GERK+TLCGTPNYIAPEVL KKGHSYEVDVWSLGCILYTLLVG+PPFET +LK+TY+RIK NEY +PS +GPLARNLI +LLQ++P +RP++ EIL+DDFMT GYLP RLP SCL+M PRFD K N +LIA++ PL+E N    ++  T    DG+K   SG  +  L       +L   L++++++KP  R    E+EAEDP S P+VWVSKWVDYSDKYGFGY+L+D+SIGV+FND+T+LLLL+DG NIHYID++G EHY++LT +P T+EKKVKLLNYFRNYMKEHLLKAGAN+E R+ D LSRIPSLKTWFRTSRAVVM LSNGT+QINFFKDHTKIILCPL+ A TYID+ + +RTFRFDL++K+GC Q++A+RL YA+DK+++M+ S
Sbjct:    1 MSSRVPLETPVVAKEIPDVITDPSTKRTYERGKFLGKGGFAKCYELKDKATGEIVAGKIVPKSMLTKAHQKEKMAQEIRLHKIVRHSYIVKLFSYFEDSNFVYVIMELCRKKSLMELHKRRQAITEPETRYFMRQMLLGCQYLHENKIIHRDLKLGNVFLNDDLEIKIGDFGLATKVDFEGERKKTLCGTPNYIAPEVLSKKGHSYEVDVWSLGCILYTLLVGKPPFETQSLKDTYNRIKRNEYHIPSKIGPLARNLIAKLLQNDPMKRPSVTEILKDDFMTMGYLPCRLPQSCLSMAPRFDNKLNASLIARKNPLSEYNRISESSSSTGEKKDGVKGSVSGPSDCHLG------ELFAMLRKLVESKPGSRVQAQEEEAEDPMSQPLVWVSKWVDYSDKYGFGYSLNDDSIGVVFNDLTKLLLLADGHNIHYIDYDGGEHYHSLTEYPETIEKKVKLLNYFRNYMKEHLLKAGANMEIRDEDVLSRIPSLKTWFRTSRAVVMHLSNGTIQINFFKDHTKIILCPLLGAVTYIDDTRRNRTFRFDLLEKYGCSQDIAARLNYAYDKIDAMMKS 567          

Query:    5 ARTVDPNAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKK-PSSGSDNGQLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
            +R+  P  + IP II DP+  K+Y+RGK LGKGGFA+C+EL DM T EI+AGKIVPKSLL KPHQR+KMTQEI +HK L H Y+V    +FED + VYIILELCRRRSLMELHKRRKA+TEPETRYF+ QIL+G KYLHD+KIIHRDLKLGN+FLND+M+IK+GDFGLAT V   GERK+TLCGTPNYIAPEVL KKGHS+EVDVWS+GCI+YTLLVGRPPFET TLKETY++IK NEY VPS +GPLA++LI R+LQ +P+RRP +++IL DDFMT GY+P RLP+SCLTM PRFD K N +++A R PL E+N       +++   K  P   S++     E  L+DL  QLK++I +K S     N D+AEDP+S+PMVW+SKWVDYSDKYGFGY L D+SIGV+FND+TRLLLLS+G +IHYI+ +G E+Y++LT FP +L+KKVKLL+YFRNYM EHLLKAGA +  REGDELSRIPSL+ WFRTSRAVVM ++NGT QINFFKDHTKIILCPLMSA TYIDE K+ RT++   +++ GC  +L  RL YA +KV+ ++ S S
Sbjct:    3 SRSDRPEPETIPTIIVDPSTKKKYQRGKLLGKGGFARCFELTDMATNEILAGKIVPKSLLTKPHQRDKMTQEIPIHKALHHKYIVGFHGFFEDPNHVYIILELCRRRSLMELHKRRKAITEPETRYFLRQILIGVKYLHDNKIIHRDLKLGNLFLNDEMEIKIGDFGLATNV-VGGERKKTLCGTPNYIAPEVLNKKGHSFEVDVWSIGCIMYTLLVGRPPFETQTLKETYAKIKKNEYHVPSRIGPLAKDLIMRMLQGDPTRRPTVHQILTDDFMTLGYVPSRLPLSCLTMAPRFDAKLNSSIVAVRRPLGEINQKENLPQVSAPVAKSVPQKKSES----PEALLLDLHTQLKDLIQSKNSKNAKANMDDAEDPESVPMVWISKWVDYSDKYGFGYQLCDDSIGVIFNDLTRLLLLSNGKDIHYIERDGTENYHSLTTFPASLDKKVKLLSYFRNYMNEHLLKAGALMAPREGDELSRIPSLQKWFRTSRAVVMHMTNGTFQINFFKDHTKIILCPLMSAVTYIDEHKSFRTYKLSSLKEFGCHVDLYDRLHYAFEKVDFLVNSRS 565          

Query:   13 KEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTS--DGMKKPSSGSDNGQLN--------------------------TENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIA 568
            KEIPE+I D    ++Y+RGKFLGKGGFA+CYEL DM TKEI AGKIV KSLLVK HQ+EKM+QEI++H+ L   ++V    +FED   VYIILELCRRRSLMELHKRRKAVTEPETRYF+ Q+LLG K+LHD K+IHRDLKLGN+FLND+M++K+GDFGLATRVD++GERKRTLCGTPNYIAPE+L KKGHSYEVDVWSLGCILYTLLVG+PPFET TLK+TY RIK NEY +PS +GPLAR+LI RLLQ +P+RRPN++ IL DDFMT GY+P RLP SCLTM PRFD++   +++A R PL E+NT   +       DG+KK   G+  G  +                          T+ +L +L  Q+  V+ +KP  R+ INEDE+EDP ++PM+WVSKWVDYSDKYG GY L D+SIGVLFND T+LLLL+DG NIHYI+    EHY+TL ++P  L KKV LL YFRNYM EHLLKA A++  REGDEL+RIPSL+T+FRT  A+++ L+NGTLQINFF+DHTKIILCPLM A TYIDE +N +T+R   ++K+GC  +LA+R+ YA + +  ++ 
Sbjct:   10 KEIPEVIYDSTTGRKYQRGKFLGKGGFARCYELTDMKTKEIFAGKIVAKSLLVKQHQKEKMSQEISIHRSLKDRHIVGFHGFFEDSDNVYIILELCRRRSLMELHKRRKAVTEPETRYFLKQLLLGVKHLHDRKVIHRDLKLGNLFLNDEMELKIGDFGLATRVDYEGERKRTLCGTPNYIAPEILCKKGHSYEVDVWSLGCILYTLLVGKPPFETQTLKDTYMRIKKNEYHIPSRIGPLARSLIQRLLQGDPTRRPNVDSILADDFMTMGYIPTRLPTSCLTMAPRFDSRC--SIVATRKPLLEINTKDGSPIKVGLKDGVKKTEVGTGRGTASAPIGSTAQQQAVAQQAASAQHKSDEPTDCYLKELYAQITSVVASKPDERDNINEDESEDPAAVPMIWVSKWVDYSDKYGLGYQLCDDSIGVLFNDFTKLLLLADGENIHYIERSNAEHYHTLKSYPGALNKKVTLLRYFRNYMNEHLLKAAASMCPREGDELARIPSLRTYFRTRSAIILHLTNGTLQINFFEDHTKIILCPLMGAVTYIDEKRNFKTYRLASLEKYGCRPDLANRMRYARNMIQKLMV 591          

Query:    9 DPNAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACL---TSDGMK---KPSSGSDNGQLNT-----ENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASL 570
            +P    IP+I+ D    KRY+RG+FLGKGGFAKCYEL D+D  ++ AGKIV K LLVKPHQ++KM QEI++H+ L H +VV   S+FED++FVYI+LELC+RRSLMELHKRRKAVTEPE RYFM+Q+LLG KYLH++K+IHRDLKLGN+FLND+M++K+GDFGLAT++DF GERK+TLCGTPNYIAPEVL KKGHS+EVD+WS+GCILYTLLVGRPPFET +LK+TYS+IK NEY +PS +GPLAR LI R+LQ +P+ RP ++ +L D+FMT GY+P RLP+SCLTM PRFD K N ++IA R PL E+N             DG+    +P+   + G L T     E  L +LQ+QL  +   KP+ +  +  DEAEDP S+PMVW+SKWVDYSDKYGFGY LSD++IGV+FND+T+LLLL D   I Y++  G+E YYT+   P TL KKVKLL YFR+YM+EHL+K GA++  R+GDE  R+P L+ WFRTSRAVVM L++GTLQIN+FKDH K+ILCPLM A T IDE KN RTF+F L+ +HGC  +L  RL YAH+K+  +++ L
Sbjct:    8 EPGPDIIPDILCDAAGKKRYQRGRFLGKGGFAKCYELTDLDNGQVFAGKIVSKQLLVKPHQKDKMAQEISIHRSLKHDHVVGFHSFFEDNNFVYIVLELCKRRSLMELHKRRKAVTEPEARYFMHQLLLGVKYLHENKMIHRDLKLGNLFLNDNMELKIGDFGLATKLDFSGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSMGCILYTLLVGRPPFETQSLKDTYSKIKRNEYHIPSRIGPLARALITRMLQGDPTCRPAVDIVLNDEFMTCGYMPTRLPLSCLTMAPRFDAKLNSSIIAVRRPLGEVNRVHLPGTAEHPQGDGLAPSNEPNHAENAGALYTAGPSPEKLLRELQQQLTRLFSAKPAEKFPLMMDEAEDPGSVPMVWISKWVDYSDKYGFGYQLSDDTIGVIFNDLTKLLLLVDAKTIQYVERNGNELYYTMDQHPPTLGKKVKLLAYFRSYMQEHLIKTGASVVPRDGDEHLRLPFLRQWFRTSRAVVMHLTSGTLQINYFKDHVKLILCPLMGAVTVIDEKKNFRTFKFSLLAEHGCNPDLLYRLQYAHEKLPFLLSPL 580          

Query:    1 MSSKARTVDPNAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFD-TKTNMNLIAQRGPLTELNT-------------DMRNACLTSDGMKKPSSGSDNG-QLNTENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
            MSSK    D   K++P+++ DP   KRY RG++LGKGGFAKCYEL D DTKEI+AGKIV K+LLVKPHQ+EKMTQEI +H+ L   +VV   S+FEDD  VYI+LELC +RSLMELHKRRKA+TEPE RYF +Q LLG KYLH++K+IHRDLKLGN+FLND M+IK+GDFGLAT++D+DGERK+TLCGTPNYIAPEVL KKGHSYEVDVWSLGCILYTLLVG+PPFET +LKETY RIK NEY VPS V PLA+NLI +LLQ +P  RP++++IL  DF + G+LP  LP SCL+  PRF  + ++M     R PL ++N+             D  N     +  K  S   D+G ++  + +L DL  QL +++ +KP+ + VI EDEAE+P + P+ W+SKWVDYSDKYG GY LSD S+GVLFND TRL+L  DG  + YI+ EG EH++ ++ +P  L KKV LL YFRNYM EHLLKAGAN++ R+ D +SR+P L+TWFRT  A+V+ LSNGTLQINFF+DHTK+ILCP+M A TYID+ +N RTFRF+L+++HGC +ELASR+ YA   V  ++AS S
Sbjct:    1 MSSKP---DLKVKDVPDVVLDPKSRKRYARGRYLGKGGFAKCYELVDPDTKEILAGKIVSKALLVKPHQKEKMTQEIAIHRSLKDHHVVGFRSFFEDDDNVYILLELCTKRSLMELHKRRKAITEPEARYFTHQTLLGVKYLHENKVIHRDLKLGNLFLNDTMEIKIGDFGLATKLDYDGERKKTLCGTPNYIAPEVLAKKGHSYEVDVWSLGCILYTLLVGKPPFETASLKETYMRIKKNEYHVPSRVSPLAKNLIDQLLQADPGARPSVSKILDHDFFSTGFLPTTLPTSCLSTAPRFALSISSMGQPISRKPLGDVNSQGSAEQAITAHKRDGENKVEGGESGKVQSDRQDDGNEMPADFWLSDLHMQLTQLMASKPAEKPVIREDEAEEPAACPIYWISKWVDYSDKYGLGYQLSDGSVGVLFNDSTRLVLNEDGETMQYIEKEGAEHFHKMSVYPDMLTKKVTLLKYFRNYMSEHLLKAGANMKPRDADNISRLPFLRTWFRTRSAIVLHLSNGTLQINFFQDHTKVILCPIMGASTYIDDKRNFRTFRFNLLEEHGCSRELASRMRYARTMVERLMASKS 583          

Query:   13 KEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELN------------TDMRNACLTSDGMKKPSSGSDNGQLN-----TENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
            K+IP+I+ DP   KRY +G+FLGKGGFAKCYEL D DTKEI AGKIVPKSLLVK HQ++KMTQEI++H+ + H ++VK  S+FED   VYI+LELCRRRSLMELHKRRKAVTEPE RYF+ Q++L C+YLH++KIIHRDLKLGN+F+ND+M++K+GDFGLATRVD+DGERKRTLCGTPNYIAPEVLGKKGHS+EVDVWSLGCILYTLLVG+PPFET  LK+TY +IK NEY VPS V   A+NLI +LL+ +P+ RPN+  +L ++F   GYLP RLP SCLTM PRFDT      +++R PL E+N            TDM+      D     S  +D G+        + +L DL   L  VI +KPS +  + E+EAEDP S+P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL+LL++G NI YI+ +G EHY+TL  FP TL KKV LL YFRNYM EHLLKAGAN+  REGD+++R+P L+ WFRT  A+V+ LSNGTLQINFF+DHTKIILCPLM A TYIDE ++   F+   I+K+GC +ELASRL YA   V  ++ S S
Sbjct:   12 KDIPDIVIDPGNGKRYLKGRFLGKGGFAKCYELTDADTKEIFAGKIVPKSLLVKQHQKDKMTQEISIHRSVSHKHIVKFHSFFEDMDNVYILLELCRRRSLMELHKRRKAVTEPEARYFVRQVILACQYLHNTKIIHRDLKLGNLFINDEMEVKIGDFGLATRVDYDGERKRTLCGTPNYIAPEVLGKKGHSFEVDVWSLGCILYTLLVGKPPFETSCLKDTYMKIKKNEYHVPSRVSLPAKNLIMKLLKGDPTDRPNMETLLEEEFFHTGYLPPRLPTSCLTMAPRFDTLARSEALSRR-PLLEINRADGNSRPQTAPTDMKK----DDKYPADSEETDEGRRKGSDEPADYYLSDLFAILSTVIASKPSEKIHVQEEEAEDPASIPIYWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILLANGENIQYIERDGTEHYHTLKVFPETLTKKVTLLKYFRNYMNEHLLKAGANMTPREGDDMTRLPFLRHWFRTRSAIVLHLSNGTLQINFFQDHTKIILCPLMQAVTYIDEKRDFHIFKLSGIEKYGCTRELASRLRYARTMVERLMTSKS 582          

Query:    1 MSSKARTVDPNAKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELN------------TDMRNACLTSDGMKKPSSGSDNGQLNTEN-----FLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIASLS 571
            MSS  R  +   K+IP+I+ DP   KRY +G+FLGKGGFAKCYEL D DTKEI AGKIVPKSLLVK HQ++KMTQEI++H+ + H ++VK  S+FED   VYI+LELCRRRSLMELHKRRKAVTEPE RYF+ Q++  C+YLH++KIIHRDLKLGN+F+ND+M++K+GDFGLATRVD+DGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVG+PPFET  LK+TY +IK NEY VPS V   A+NLI +LL+ +P+ RPN++ +L ++F   GYLP RLP SCLTM PRFDT      +++R PL E+N            TD++      D     S  +D G+    +     +L DL   L  VI +KPS +  I E+EAEDP S+P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL+LL++G N+ YI+ +G EHY+TL  FP T+ KKV LL YFRNYM EHLLKAGAN+  REGD+++R+P L+ WFRT  A+V+ LSNGTLQINFF+DHTKIILCPLM A TYIDE ++   F+   I+K+GC +ELASRL YA   V  ++ S S
Sbjct:    1 MSSAVRREEIR-KDIPDIVIDPGNGKRYLKGRFLGKGGFAKCYELTDADTKEIFAGKIVPKSLLVKQHQKDKMTQEISIHRSVSHKHIVKFHSFFEDMDNVYILLELCRRRSLMELHKRRKAVTEPEARYFVRQVITACQYLHNTKIIHRDLKLGNLFINDEMEVKIGDFGLATRVDYDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGKPPFETSCLKDTYMKIKKNEYHVPSRVSLPAKNLIMKLLKGDPTDRPNMDTLLEEEFFHTGYLPPRLPTSCLTMAPRFDTLARSEALSRR-PLLEINRADGNSRPQTAPTDIKK----DDKYPTESEETDEGRRKGSDEPADYYLSDLFAILSTVIASKPSEKIQIQEEEAEDPASIPIYWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILLANGENVQYIERDGTEHYHTLKVFPETMTKKVTLLKYFRNYMNEHLLKAGANMTPREGDDMTRLPFLRHWFRTRSAIVLHLSNGTLQINFFQDHTKIILCPLMQAVTYIDEKRDFHVFKLSGIEKYGCTRELASRLRYARTMVERLMTSKS 582          

Query:    3 SKARTVDPN----AKEIPEIIRDPNRPKRYERGKFLGKGGFAKCYELKDMDTKEIMAGKIVPKSLLVKPHQREKMTQEITLHKGLGHLYVVKLFSYFEDDHFVYIILELCRRRSLMELHKRRKAVTEPETRYFMNQILLGCKYLHDSKIIHRDLKLGNIFLNDDMQIKLGDFGLATRVDFDGERKRTLCGTPNYIAPEVLGKKGHSYEVDVWSLGCILYTLLVGRPPFETHTLKETYSRIKNNEYQVPSTVGPLARNLIGRLLQHEPSRRPNINEILRDDFMTKGYLPHRLPVSCLTMTPRFDTKTNMNLIAQRGPLTELNTDMRNACLTSDGMKKPSSGSDNGQLN-------TENFLVDLQKQLKEVIDTKPSLRNVINEDEAEDPKSLPMVWVSKWVDYSDKYGFGYALSDESIGVLFNDITRLLLLSDGSNIHYIDFEGHEHYYTLTNFPTTLEKKVKLLNYFRNYMKEHLLKAGANIETREGDELSRIPSLKTWFRTSRAVVMQLSNGTLQINFFKDHTKIILCPLMSACTYIDEDKNHRTFRFDLIQKHGCGQELASRLTYAHDKVNSMIAS 569
            S     DP      KEIP+I+ DP   K+Y RGKFLGKGGFAKCYE+ DM+TKE+ AGKIVPKS+L+KPHQ+EKM+ EI+LHK L H +VV    +FED+ FV+++LELCRRRSL+ELHKRRKAVTEPE RYF+ Q +LGC++LH S++IHRDLKLGN+FLNDDM++K+GDFGLAT+V++DGERK+TLCGTPNYIAPEVLGKKGHS+EVD+WSLGCI+YTLLVG+PPFET  LKETY RIK NEY VP  + P+A  LI ++L+ +P+ RP I+++L DDF T GY+P+RLP +CLT+ PRF    N    + R PLT +N +  N  L+    +K     D  ++        T  +L D+ +QL  V   +PS R +I ++EAEDP S+P+ WVSKWVDYSDKYG GY L D S+GVLFND TRL++ +DG ++ YI+    E Y  + +FPT+L KK+ LL YFRNYM EHLLKAGANI  REGDEL+R+P L+TWFRT  A+V+ LSNGT+QINFF+DHTKIILCPLM+A TYIDE+++ R ++  LI++HGC +ELASRL YA   V  ++ S
Sbjct:   13 SAPSVADPTKTVAVKEIPDILVDPRTKKKYVRGKFLGKGGFAKCYEITDMETKEVFAGKIVPKSMLMKPHQKEKMSMEISLHKSLSHPHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKAVTEPEARYFLRQTILGCQFLHGSRVIHRDLKLGNLFLNDDMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSLGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSVPKHINPVATALIQKMLRADPTTRPTIDDLLNDDFFTSGYVPNRLPTTCLTVPPRFSIAPNSIDASIRKPLTAINKE--NPVLS----EKLGKVEDKEEMQYRELGEPTGCYLSDMLEQLNSVNMARPSERPLIRQEEAEDPASIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNYSESYLNMRSFPTSLSKKITLLKYFRNYMSEHLLKAGANITPREGDELARMPYLRTWFRTRSAIVIHLSNGTVQINFFQDHTKIILCPLMAAVTYIDENRDFRVYKLSLIEEHGCCKELASRLRYARTMVEKLMGS 584