BLAST of adenylate cyclase type 8 isoform x2 vs. L. salmonis genes
Match: EMLSAG00000007027 (supercontig:LSalAtl2s:LSalAtl2s39:14509:15553:-1 gene:EMLSAG00000007027 transcript:EMLSAT00000007027 description:"maker-LSalAtl2s39-snap-gene-0.31")

HSP 1 Score: 71.2478 bits (173), Expect = 6.135e-14
Identity = 41/145 (28.28%), Postives = 78/145 (53.79%), Query Frame = 0

Query:  427 DICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLS 571
            ++  F  L  T T  ++V  LN +    D++       +++ + D Y   SGVP+ + +  +HA    +M L + K I  +     + + M+ G+HTG   +GI+G K  ++ ++   V  A++MES G+PG +HI+ +T++ L+
Sbjct:   11 ELIGFAGLGKTNTAMEIVNLLNRVHKVSDESISQYDVYKVETIRDQYMVSSGVPRRNGD--DHAGEIAKMALTLNKTIHNMVSIKKLGLQMQCGIHTGPCVAGIVGTKMPRYCLFGDTVNTASRMESRGQPGKIHISNETQIILT 153          

HSP 2 Score: 68.5514 bits (166), Expect = 5.037e-13
Identity = 46/153 (30.07%), Postives = 76/153 (49.67%), Query Frame = 0

Query:  961 IEKIKVISSTYMAASGLQPGRKG---SGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMA-QNVSCTYRDEIFVKGKGKMKVFFV 1109
            + K++ I   YM +SG+ P R G   +GEI +  + L++  HN           ++KL             Q++ G+  G  +AG+VG + P Y ++G+TVN ASRM+  G  GKI +      +L          R  I VKGKG+++ +++
Sbjct:   47 VYKVETIRDQYMVSSGV-PRRNGDDHAGEIAKMALTLNKTIHNM--------VSIKKL-----------GLQMQCGIHTGPCVAGIVGTKMPRYCLFGDTVNTASRMESRGQPGKIHISNETQIILTTIGGYKLELRGTIEVKGKGELETYWL 179          

BLAST of adenylate cyclase type 8 isoform x2 vs. L. salmonis genes
Match: EMLSAG00000011610 (supercontig:LSalAtl2s:LSalAtl2s802:171192:182845:1 gene:EMLSAG00000011610 transcript:EMLSAT00000011610 description:"snap_masked-LSalAtl2s802-processed-gene-1.9")

HSP 1 Score: 68.1662 bits (165), Expect = 1.269e-11
Identity = 45/156 (28.85%), Postives = 79/156 (50.64%), Query Frame = 0

Query:  398 DMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIG--VVRHANNVNVDMRIGVHTGLIFSGIIG---IKKWQFDIWSKDVIIA 548
            D+  +L    +P  +L+    E+ ++ F DI  FT LT   T  + ++ LNDL+  FD+  +     +++I+GD Y   SG+P P+  K  HA     M L ++  +    + H     + MR+G+H+G    G +G   ++K +F+   +  IIA
Sbjct:  546 DIIAKLKAGDQPPPKLY----ESATVFFGDIVGFTNLTAMSTAGQTIQFLNDLYNMFDNYIDNFDVYKVEIVGDGYLVASGLPIPNGYK--HATEIATMALQLMFQVEGFKISHKPTYKLRMRMGIHSG----GCVGSRLLEKGKFETEVRGQIIA 691          

BLAST of adenylate cyclase type 8 isoform x2 vs. L. salmonis genes
Match: EMLSAG00000011236 (supercontig:LSalAtl2s:LSalAtl2s76:248241:250196:-1 gene:EMLSAG00000011236 transcript:EMLSAT00000011236 description:"augustus_masked-LSalAtl2s76-processed-gene-2.0")

HSP 1 Score: 65.855 bits (159), Expect = 5.309e-11
Identity = 74/284 (26.06%), Postives = 143/284 (50.35%), Query Frame = 0

Query:  842 IFLLLCALMHEYMYRLDFQWKRQ-LKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGV--VGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDE---IFVKGKGKMKVFFVDIDEVGVIVT 1119
            IFL+  A +   ++ L    K Q LK E++ A       ++LL  ILP  +A L ++N +S   +++E  E V V+ + +  + ++    +T  V ++  LN +   FD       +  ++ K++ ++ ++M  SG+ P + G     +HG ++      A +     A+ +  ++  + KE      QLRIG+  G +IAGV  VG + P Y ++G +VN+A+ ++ TG   +I V  S+   L+   +   + ++   I +K KG ++ F++ + + G I T
Sbjct:  367 IFLVRNATVTIQVFSLSLSKKAQELKMEKKKA-------DMLLFQILPQQIA-LNLTNKKS---VFAERIESVTVLISDVVGFQEM-VHTNTP-VETVIFLNMLYKMFD----TRTDKYEVYKVETVNDSFMVVSGV-PAKIGQSLGNKHGSEI------AXLALDLQASSVGFITPNRPKE----RLQLRIGIHSGPLIAGVQSVGNKMPKYRLFGESVNIAAHLNATGEAHRIHV--SVEAKLLLDTLGGFHFEKSGMIEMKAKGLVETFWL-VSKEGAIFT 619          

HSP 2 Score: 60.4622 bits (145), Expect = 2.867e-9
Identity = 41/166 (24.70%), Postives = 85/166 (51.20%), Query Frame = 0

Query:  411 KQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVP-KPDEEKPN-HAENCVEMGLAM-IKHIGVVR-HANNVNVDMRIGVHTGLIFSGI--IGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQL 570
            K +   + E+V++L +D+  F  +  T T  + V  LN L+  FD   +  +  +++ + D +  VSGVP K  +   N H      + L +    +G +  +     + +RIG+H+G + +G+  +G K  ++ ++ + V IA  + +TG+   +H++ + K+ L
Sbjct:  418 KSVFAERIESVTVLISDVVGFQEMVHTNTPVETVIFLNMLYKMFDTRTDKYEVYKVETVNDSFMVVSGVPAKIGQSLGNKHGSEIAXLALDLQASSVGFITPNRPKERLQLRIGIHSGPLIAGVQSVGNKMPKYRLFGESVNIAAHLNATGEAHRIHVSVEAKLLL 583          

BLAST of adenylate cyclase type 8 isoform x2 vs. L. salmonis genes
Match: EMLSAG00000009924 (supercontig:LSalAtl2s:LSalAtl2s647:1118:4493:-1 gene:EMLSAG00000009924 transcript:EMLSAT00000009924 description:"augustus_masked-LSalAtl2s647-processed-gene-0.0")

HSP 1 Score: 65.855 bits (159), Expect = 5.620e-11
Identity = 49/207 (23.67%), Postives = 98/207 (47.34%), Query Frame = 0

Query:  375 LLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVV------RHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYL 575
            LL  +IP  I E V+  I                P+        E V+I+F ++  F+ +       ++V  LN+LFG FD  ++ +   +++ + D +  V+G P   E+  +HAE   +M L M   +  +          N ++ + +G H+G + +GIIG K  ++ ++   +  +++M S+G+   +HI++  + +L   Y+
Sbjct:  383 LLAQMIPKEIVEKVKAGIN---------------PVNTCQYF--ECVTIVFNNVHGFSDICAKCDGMEIVALLNNLFGMFDHLSDKHLVYKVETVKDSFVGVAGAP---EKTEDHAERIADMLLDMKDSVEFLPDPRPEYKNTNEHIKIGLGAHSGSVVAGIIGNKCPRYCLFGDAMNTSSRMMSSGEEQRIHISKSLQKKLPSDYI 569          

HSP 2 Score: 59.3066 bits (142), Expect = 5.524e-9
Identity = 64/286 (22.38%), Postives = 132/286 (46.15%), Query Frame = 0

Query:  844 LLLCALMHEYMYRLDFQWKRQLK-------SEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGV-------------NDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFV 1109
            +LLC+   EY   L+   + +++       S +E    TK +++LL + ++P  + +   +      T   + +E V ++F ++  + D+  K D   + +L  LN +   FD L     + + + K++ +  +++  +G  P +               + H  RI     A M+     L +K+ V             N+  ++ +G   G V+AG++G + P Y ++G+ +N +SRM  +G E +I + +S+ + L +  ++   R  I VKGKG M  +++
Sbjct:  341 ILLCS--SEYSDNLNKHLEEEIEKSKLLEMSMKEIDEETKRSDDLLAQ-MIPKEIVEKVKAGINPVNT--CQYFECVTIVFNNVHGFSDICAKCDGMEIVAL--LNNLFGMFDHL----SDKHLVYKVETVKDSFVGVAG-APEKT--------------EDHAERI-----ADML-----LDMKDSVEFLPDPRPEYKNTNEHIKIGLGAHSGSVVAGIIGNKCPRYCLFGDAMNTSSRMMSSGEEQRIHISKSLQKKLPSDYIT-KERGTIKVKGKGNMTTYWL 589          

BLAST of adenylate cyclase type 8 isoform x2 vs. L. salmonis genes
Match: EMLSAG00000009774 (supercontig:LSalAtl2s:LSalAtl2s633:197084:200372:1 gene:EMLSAG00000009774 transcript:EMLSAT00000009774 description:"snap_masked-LSalAtl2s633-processed-gene-2.9")

HSP 1 Score: 60.077 bits (144), Expect = 2.953e-9
Identity = 44/200 (22.00%), Postives = 89/200 (44.50%), Query Frame = 0

Query:  376 LLSIIPAHITEPVRK------RIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVR--HANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTK 567
            ++ I    + E VR+      +  +  +D   +  V     K++     + V++ F DI  F  LT+  T  +L++ +N  + S D          +  +GD +  VSG+  P++   +H      M L ++    V +  H  N  + +R+G+H+G     + G K   + +     I+A+ +E  G+   +H++E +K
Sbjct:  222 VIRIFAKEVMEKVRELDAEKMKTEKAFHDFLPKTVVRDLKRKRVLAENFDCVTVFFGDIIGFNDLTSDCTPSELIDFMNLFYASLDARIAKFNVYNVHTMGDEFMVVSGM--PNKIGNHHVSEVASMSLDLLAASVVFQIPHRPNSRLHIRMGIHSGPACGVVAGSKIPNYCVMGDTTIVAHMVEKMGEGMKIHLSEASK 419          

BLAST of adenylate cyclase type 8 isoform x2 vs. L. salmonis genes
Match: EMLSAG00000007490 (supercontig:LSalAtl2s:LSalAtl2s430:123975:126323:1 gene:EMLSAG00000007490 transcript:EMLSAT00000007490 description:"maker-LSalAtl2s430-augustus-gene-1.20")

HSP 1 Score: 52.7582 bits (125), Expect = 6.679e-7
Identity = 36/142 (25.35%), Postives = 71/142 (50.00%), Query Frame = 0

Query:  417 KQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVP-KPDE----EKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGI--KKWQFDIWSKDVIIANQM 551
            K E+VS+L++DI +FT +  T +  + V  LN L+  FD   +     ++  + D Y  VSG+P KP +    E P +  + + + L     + V+ H+    + +R  +H      G++ +  K  ++ ++   V +A+Q+
Sbjct:  449 KMESVSVLYSDIQDFTSMVQTSSPIETVILLNSLYKMFDSRIDKYDVYKVNNINDSYMIVSGIPSKPGKMASSEYPAYELSTLAIDLIGGSSMFVIPHSPKERLLVRXXIHXXPAIGGVLTVRNKMPRYRLFGDSVYVAHQL 590          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|12644065|sp|O43306.2|ADCY6_HUMAN (RecName: Full=Adenylate cyclase type 6; AltName: Full=ATP pyrophosphate-lyase 6; AltName: Full=Adenylate cyclase type VI; AltName: Full=Adenylyl cyclase 6; AltName: Full=Ca(2+)-inhibitable adenylyl cyclase)

HSP 1 Score: 258.84 bits (660), Expect = 3.203e-69
Identity = 177/543 (32.60%), Postives = 269/543 (49.54%), Query Frame = 0

Query:  248 PIMSLYNLLVIYLFLPIP-KKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEPIPPID-DTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVIL 788
            P+  +Y   + Y  LPI  + +V  G G++     + + LA +L+ G        KQL A+++ +L  N IG+   Y  E++ R+ F + RG I     L++E  Q+                   E LLLS++P H+   +++ I     DM            ++++ K +NVSILFADI  FT L +  T ++LV TLN+LF  FD  A  N C+RIKILGDCYYCVSG+P   E + +HA  CVEMG+ MI+ I +VR    VNV+MR+G+H+G +  G++G++KWQFD+WS DV +AN ME+ G+ G +HIT  T   L+  Y  EP    + +  L++  I TFLI  A +K  +++   A L           TR NS + G +      R  S          R +  +   + G  D  +D          + G +   N      +F+   I+    R  DQ L  + +    L F+ +  EK Y ++ DP F  Y+    ++   +  I LL   H  L+L G Y  IF++L
Sbjct:  242 PVFFVY---IAYTLLPIRMRAAVLSGLGLST----LHLILAWQLNRG---DAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQ-------------------ERLLLSVLPQHVAMEMKEDINTKKEDMM---------FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP---EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQ---------RTRANS-MEGLMPRWVPDRAFS----------RTKDSKAFRQMGIDDSSKD----------NRGTQDALNPEDEVDEFLSRAIDA---RSIDQ-LRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLML-GIYASIFLLL 708          

HSP 2 Score: 180.259 bits (456), Expect = 1.792e-44
Identity = 113/284 (39.79%), Postives = 158/284 (55.63%), Query Frame = 0

Query:  830 KRINESLLARSTIFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDT--EYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGH-NARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVD 1110
            K +   +L    + L L A   E   RLDF WK Q   E+E     +  N  LL NILP  VA  +++  R    LY +S E VAVMFASI  + + + +++   E V  L  LN II+ FD+++  +  F ++EKIK I STYMAASGL                 D+ G  +   LA +A  +M ++    I E   + FQ++IGL+ G V+AGV+GA+KP YDIWGNTVNV+SRMD TG   +IQV   + +VL A+      R  + VKGKG+M  +F++
Sbjct:  895 KYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEII-SEERFRQLEKIKTIGSTYMAASGLNAS------------TYDQVGRSHITALADYAMRLMEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1163          

HSP 3 Score: 74.3294 bits (181), Expect = 6.467e-12
Identity = 53/208 (25.48%), Postives = 97/208 (46.63%), Query Frame = 0

Query:  882 LLRNILPHHVA-----DLYISN-NRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVL 1083
            LL ++LP HVA     D+     +     +Y + +++V+++FA I  +  L ++   + +  + TLN + + FDKL   +H      +IK++   Y   SGL   R                  +A         M+  +S ++   GVN    +R+G+  G+V  GV+G +K  +D+W N V +A+ M+  G  G+I +  +  + L
Sbjct:  341 LLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL--VMTLNELFARFDKLAAENHCL----RIKILGDCYYCVSGLPEAR----------------ADHAHCCVEMGVDMIEAISLVREVTGVN--VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYL 524          

HSP 4 Score: 72.4034 bits (176), Expect = 2.680e-11
Identity = 42/171 (24.56%), Postives = 84/171 (49.12%), Query Frame = 0

Query:  412 QLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAA---EINKCMRIKILGDCYYCVSGVPKP--DEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPK 573
            +L+    E V+++FA I NF+     +       + +  LN++   FD+        +  +IK +G  Y   SG+     D+   +H     +  + +++ +  +   +  N  M+IG++ G + +G+IG +K Q+DIW   V ++++M+STG P  + +T      L+ K
Sbjct:  969 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAK 1139          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|416857|sp|Q03343.1|ADCY6_RAT (RecName: Full=Adenylate cyclase type 6; AltName: Full=ATP pyrophosphate-lyase 6; AltName: Full=Adenylate cyclase type VI; Short=ACVI; AltName: Full=Adenylyl cyclase 6; Short=AC6; AltName: Full=Ca(2+)-inhibitable adenylyl cyclase)

HSP 1 Score: 253.832 bits (647), Expect = 1.360e-67
Identity = 179/543 (32.97%), Postives = 264/543 (48.62%), Query Frame = 0

Query:  248 PIMSLYNLLVIYLFLPIP-KKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEPIPPID-DTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVIL 788
            P+  +Y   + Y  LPI  + +V  G G++     + + LA  L+ G        KQL A++V +L  N IGV   Y  E++ R+ F + RG I     L++E  Q+                   E LLLS++P H+   +++ I     DM            ++++ K +NVSILFADI  FT L +  T ++LV TLN+LF  FD  A  N C+RIKILGDCYYCVSG+P   E + +HA  CVEMG+ MI+ I +VR    VNV+MR+G+H+G +  G++G++KWQFD+WS DV +AN ME+ G+ G +HIT  T   L+  Y  EP    + +  L++  I TFLI  A +K   +++  A L  L +      TR NS              G M            +  K      IDD         S   + G +   N      +F+   I+    R  DQ L  + +    L F+ +  EK Y ++ DP F  Y+    ++   +  I  L   H  L+L G Y  IF++L
Sbjct:  240 PVFFVY---ITYTLLPIRMRAAVLSGLGLST----LHLILAWHLNNGDPF---LWKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQ-------------------ERLLLSVLPQHVAMEMKEDINTKKEDMM---------FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP---EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNGYLKEQCIETFLILGASQK---RKEEKAMLVKLQR------TRANS------------MEGLMPRWVPDRAFSRTKDSKAFRQMGIDD---------SSKENRGAQDALNPEDEVDEFLGRAIDA---RSIDQ-LRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQFLVFPHSALIL-GIYAGIFLLL 706          

HSP 2 Score: 180.259 bits (456), Expect = 1.896e-44
Identity = 113/284 (39.79%), Postives = 159/284 (55.99%), Query Frame = 0

Query:  830 KRINESLLARSTIFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDT--EYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGH-NARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVD 1110
            K +   +L    + L L A   E   RLDF WK Q   E+E     +  N  LL NILP  VA  +++  R    LY +S E VAVMFASI  + + + +++   E V  L  LN II+ FD+++  +  F ++EKIK I STYMAASGL            +    D+ G  +   LA +A  +M ++    I E   + FQ++IGL+ G V+AGV+GA+KP YDIWGNTVNV+SRMD TG   +IQV   + +VL A+      R  + VKGKG+M  +F++
Sbjct:  893 KYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEII-SEERFRQLEKIKTIGSTYMAASGL------------NASTYDQVGRSHITALADYAMRLMEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1161          

HSP 3 Score: 73.9442 bits (180), Expect = 7.526e-12
Identity = 53/208 (25.48%), Postives = 97/208 (46.63%), Query Frame = 0

Query:  882 LLRNILPHHVA-----DLYISN-NRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVL 1083
            LL ++LP HVA     D+     +     +Y + +++V+++FA I  +  L ++   + +  + TLN + + FDKL   +H      +IK++   Y   SGL   R                  +A         M+  +S ++   GVN    +R+G+  G+V  GV+G +K  +D+W N V +A+ M+  G  G+I +  +  + L
Sbjct:  339 LLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL--VMTLNELFARFDKLAAENHCL----RIKILGDCYYCVSGLPEAR----------------ADHAHCCVEMGVDMIEAISLVREVTGVN--VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYL 522          

HSP 4 Score: 71.633 bits (174), Expect = 4.451e-11
Identity = 42/171 (24.56%), Postives = 84/171 (49.12%), Query Frame = 0

Query:  412 QLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAA---EINKCMRIKILGDCYYCVSGVPKP--DEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPK 573
            +L+    E V+++FA I NF+     +       + +  LN++   FD+        +  +IK +G  Y   SG+     D+   +H     +  + +++ +  +   +  N  M+IG++ G + +G+IG +K Q+DIW   V ++++M+STG P  + +T      L+ K
Sbjct:  967 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAK 1137          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|729241|sp|P40144.1|ADCY5_RABIT (RecName: Full=Adenylate cyclase type 5; AltName: Full=ATP pyrophosphate-lyase 5; AltName: Full=Adenylate cyclase type V; AltName: Full=Adenylyl cyclase 5)

HSP 1 Score: 251.521 bits (641), Expect = 1.099e-66
Identity = 188/668 (28.14%), Postives = 307/668 (45.96%), Query Frame = 0

Query:  137 YLTERFQGKQLEGIYKRYEQRTQIGTFT--------------TYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSLQLNKPLLPNDNGTSSIYSEDAFFSEFIPESTPTGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEP-IPPIDDTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVILT 789
            + +++F   +LE +Y+RY  R    + T               +   +  L + Y+  +A          VG+++  ++  N+     D+   + Y+  A     +      G   P+    ++    +++ +  IY  LP+  ++          V+  T+ LAI L T   +    +KQL+++++ +   N +GV   Y  E++ R+ F + R CI      + E +Q+                   E LLLS++P H+   ++  I     DM            ++++ K +NVSILFADI  FT L +  T ++LV TLN+LF  FD  A  N C+RIKILGDCYYCVSG+P   E + +HA  CVEMG+ MI+ I +VR    VNV+MR+G+H+G +  G++G++KWQFD+WS DV +AN ME+ GK G +HIT+ T   L+  Y  EP      +  L+++ I TFLI    +K  +++   A ++      + +S   N    G      +   G+ VS         E KR   E          DPK      D   ++  N      +F+   I+    R  D+ L  E +    L FR+   EK Y K+ D  F  Y+    ++   +  + +    H   +L   Y   F++LT
Sbjct:  219 FRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAA--------VGVILVMAVLCNRAAFHQDHMGLACYALIAV----VLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLS-----GVLLSTLHLAIALRTNAQDRF-LLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQ-------------------ERLLLSVLPRHVAMEMKADINAKQEDMM---------FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP---EARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN----RQRTNSIGHNPPHWGAERPFYNHLGGNQVS--------KEMKRMGFE----------DPK------DKNAQESTNPEDEVDEFLGRAIDA---RSIDR-LRSEHVRRFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICCVQITIVPHSMFML-SFYLACFLLLT 804          

HSP 2 Score: 177.948 bits (450), Expect = 1.223e-43
Identity = 116/284 (40.85%), Postives = 159/284 (55.99%), Query Frame = 0

Query:  830 KRINESLLARSTIFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDT--EYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGH-NARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVD 1110
            K +   +++   + L L A   E   RLDF WK Q   E+E     +  N  LL NILP  VA  +++  R    LY +S E VAVMFASI  + + + +++   E V  L  LN II+ FD+++  D  F ++EKIK I STYMAASGL                 D+ G  + + LA FA  +M ++    I E   + FQ++IGL+ G V+AGV+GA+KP YDIWGNTVNVASRMD TG   +IQV   M +VL A       R  + VKGKG+M  +F++
Sbjct:  990 KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDR-FRQLEKIKTIGSTYMAASGLNDS------------TYDKVGKTHIKALADFAMKLMDQMK--YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1258          

HSP 3 Score: 74.3294 bits (181), Expect = 7.110e-12
Identity = 56/233 (24.03%), Postives = 104/233 (44.64%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPG------TLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPES 1078
            E   R  FQ  R+    +  +         LL ++LP HVA    ++  +         +Y + +++V+++FA I  +  L ++   + +  + TLN + + FDKL   +H      +IK++   Y   SGL   R                  +A         M+  +S ++   GVN    +R+G+  G+V  GV+G +K  +D+W N V +A+ M+  G  G+I + ++
Sbjct:  404 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL--VMTLNELFARFDKLAAENHCL----RIKILGDCYYCVSGLPEAR----------------ADHAHCCVEMGMDMIEAISLVREVTGVN--VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKA 612          

HSP 4 Score: 73.559 bits (179), Expect = 1.058e-11
Identity = 41/161 (25.47%), Postives = 80/161 (49.69%), Query Frame = 0

Query:  412 QLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAA---EINKCMRIKILGDCYYCVSGVPKP--DEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHIT 563
            +L+    E V+++FA I NF+     +       + +  LN++   FD+        +  +IK +G  Y   SG+     D+    H +   +  + ++  +  +   +  N  M+IG++ G + +G+IG +K Q+DIW   V +A++M+STG P  + +T
Sbjct: 1064 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT 1224          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|399317|sp|P30804.1|ADCY6_CANFA (RecName: Full=Adenylate cyclase type 6; AltName: Full=ATP pyrophosphate-lyase 6; AltName: Full=Adenylate cyclase type VI; AltName: Full=Adenylyl cyclase 6; AltName: Full=Ca(2+)-inhibitable adenylyl cyclase)

HSP 1 Score: 250.751 bits (639), Expect = 1.309e-66
Identity = 176/542 (32.47%), Postives = 266/542 (49.08%), Query Frame = 0

Query:  248 PIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEPIPPID-DTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVIL 788
            P+  +Y   + Y  LPI  ++  F  G+ +S +   + LA +L+ G        KQL A+++ +L  N IG+   Y  E++ R+ F + RG I     L  E  Q+                   E LLLS++P H+   +++ I     DM            ++++ K +NVSILFADI  FT L +  T ++LV TLN+LF  FD  A  N C+RIKILGDCYYCVSG+P   E + +HA  CVEMG+ MI+ I +VR    VNV+MR+G+H+G +  G++G++KWQFD+WS DV +AN ME+  + G +HIT  T   L+  Y  EP    + +  L++  I TFLI  A +K  +++   A L           TR NS + G +      R  S          R +  +   + G  D  +D          + G +   N      +F+   I+    R  DQ L  + +    L F+ +  EK Y ++ DP F  Y+    ++   +  I LL   H  ++L G Y  IFV+L
Sbjct:  240 PVFFVY---ITYTLLPIRMRAAVFS-GLGLSTL--HLILAWQLNRGD---AFLWKQLGANMLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLPDENRQQ-------------------ERLLLSVLPQHVAMEMKEDINTKKEDMM---------FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP---EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA-ARAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQ---------RTRANS-MEGLMPRWVPDRAFS----------RTKDSKAFRQMGIDDSSKD----------NRGAQDALNPEDEVDEFLGRAIDA---RSIDQ-LRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLVFPHSTVML-GIYASIFVLL 705          

HSP 2 Score: 180.644 bits (457), Expect = 1.413e-44
Identity = 113/284 (39.79%), Postives = 159/284 (55.99%), Query Frame = 0

Query:  830 KRINESLLARSTIFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDT--EYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGH-NARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVD 1110
            K +   +L    + L L A   E   RLDF WK Q   E+E     +  N  LL NILP  VA  +++  R    LY +S E VAVMFASI  + + + +++   E V  L  LN II+ FD+++  +  F ++EKIK I STYMAASGL            +    D+ G  +   LA +A  +M ++    I E   + FQ++IGL+ G V+AGV+GA+KP YDIWGNTVNV+SRMD TG   +IQV   + +VL A+      R  + VKGKG+M  +F++
Sbjct:  892 KYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEII-SEERFRQLEKIKTIGSTYMAASGL------------NASTYDQAGRSHITALADYAMRLMEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKRYQLECRGVVKVKGKGEMTTYFLN 1160          

HSP 3 Score: 72.7886 bits (177), Expect = 1.909e-11
Identity = 42/171 (24.56%), Postives = 84/171 (49.12%), Query Frame = 0

Query:  412 QLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAA---EINKCMRIKILGDCYYCVSGVPKP--DEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPK 573
            +L+    E V+++FA I NF+     +       + +  LN++   FD+        +  +IK +G  Y   SG+     D+   +H     +  + +++ +  +   +  N  M+IG++ G + +G+IG +K Q+DIW   V ++++M+STG P  + +T      L+ K
Sbjct:  966 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAK 1136          

HSP 4 Score: 69.3218 bits (168), Expect = 2.129e-10
Identity = 53/208 (25.48%), Postives = 97/208 (46.63%), Query Frame = 0

Query:  882 LLRNILPHHVA-----DLYISN-NRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVL 1083
            LL ++LP HVA     D+     +     +Y + +++V+++FA I  +  L ++   + +  + TLN + + FDKL   +H      +IK++   Y   SGL   R                  +A         M+  +S ++   GVN    +R+G+  G+V  GV+G +K  +D+W N V +A+ M+   A G+I +  +  + L
Sbjct:  339 LLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL--VMTLNELFARFDKLAAENHCL----RIKILGDCYYCVSGLPEAR----------------ADHAHCCVEMGVDMIEAISLVREVTGVN--VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAARA-GRIHITRATLQYL 521          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|8176552|sp|P30803.2|ADCY5_CANFA (RecName: Full=Adenylate cyclase type 5; AltName: Full=ATP pyrophosphate-lyase 5; AltName: Full=Adenylate cyclase type V; AltName: Full=Adenylyl cyclase 5; AltName: Full=Ca(2+)-inhibitable adenylyl cyclase)

HSP 1 Score: 251.521 bits (641), Expect = 1.338e-66
Identity = 202/735 (27.48%), Postives = 325/735 (44.22%), Query Frame = 0

Query:   70 PRSRSQGSDFFDGRGFATSSGRHKSRSKSGVSLDPNHLDRRGSTAFNSIIQSSDTDPGYDGRAWNLTYLTERFQGKQLEGIYKRYEQRTQIGTFT--------------TYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSLQLNKPLLPNDNGTSSIYSEDAFFSEFIPESTPTGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEP-IPPIDDTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVILT 789
            PRS   G D   GRG A      ++ +  G   D    D  G              PG   RA    + +++F   +LE +Y+RY  R    + T               +   +  L + ++  +A          VG+++  ++  N+     D+   + Y+  A     +      G   P+    ++    +++ +  IY  LP+  ++          V+   + LAI L     +    +KQL+++++ +   N +GV   Y  E++ R+ F + R CI      + E +Q+                   E LLLS++P H+   ++  I     DM            ++++ K +NVSILFADI  FT L +  T ++LV TLN+LF  FD  A  N C+RIKILGDCYYCVSG+P   E + +HA  CVEMG+ MI+ I +VR    VNV+MR+G+H+G +  G++G++KWQFD+WS DV +AN ME+ GK G +HIT+ T   L+  Y  EP      +  L+++ I TFLI    +K  +++   A ++      + +S   N    G      +   G+ VS         E KR   E          DPK      D   ++  N      +F+   I+    R  D+ L  E +    L FR+   EK Y K+ D  F  Y+    ++   +  + +    H   +L   Y   F++LT
Sbjct:  166 PRSVELGLDERRGRGRAEPEPEAEAGAPGG---DRGARDGDGPAG-----------PGACCRALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLRLPHLAVLAAA--------VGVILVMAVLCNRAAFHQDHMGLACYALIAV----VLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLS-----GVLLSALHLAIALRANAQDRF-LLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQ-------------------ERLLLSVLPRHVAMEMKADINAKQEDMM---------FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP---EARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN----RQRTNSIGHNPPHWGAERPFYNHLGGNQVS--------KEMKRMGFE----------DPK------DKNAQESANPEDEVDEFLGRAIDA---RSIDR-LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSVFML-SFYLTCFLLLT 804          

HSP 2 Score: 178.333 bits (451), Expect = 8.695e-44
Identity = 116/284 (40.85%), Postives = 159/284 (55.99%), Query Frame = 0

Query:  830 KRINESLLARSTIFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDT--EYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGH-NARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVD 1110
            K +   +++   + L L A   E   RLDF WK Q   E+E     +  N  LL NILP  VA  +++  R    LY +S E VAVMFASI  + + + +++   E V  L  LN II+ FD+++  D  F ++EKIK I STYMAASGL                 D+ G  + + LA FA  +M ++    I E   + FQ++IGL+ G V+AGV+GA+KP YDIWGNTVNVASRMD TG   +IQV   M +VL A       R  + VKGKG+M  +F++
Sbjct:  991 KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRVLNEIIADFDEIISEDR-FRQLEKIKTIGSTYMAASGLNDS------------TYDKVGKTHIKALADFAMKLMDQMK--YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1259          

HSP 3 Score: 74.3294 bits (181), Expect = 6.535e-12
Identity = 56/233 (24.03%), Postives = 104/233 (44.64%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPG------TLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPES 1078
            E   R  FQ  R+    +  +         LL ++LP HVA    ++  +         +Y + +++V+++FA I  +  L ++   + +  + TLN + + FDKL   +H      +IK++   Y   SGL   R                  +A         M+  +S ++   GVN    +R+G+  G+V  GV+G +K  +D+W N V +A+ M+  G  G+I + ++
Sbjct:  404 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL--VMTLNELFARFDKLAAENHCL----RIKILGDCYYCVSGLPEAR----------------ADHAHCCVEMGMDMIEAISLVREVTGVN--VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKA 612          

HSP 4 Score: 73.9442 bits (180), Expect = 9.401e-12
Identity = 41/161 (25.47%), Postives = 80/161 (49.69%), Query Frame = 0

Query:  412 QLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAA---EINKCMRIKILGDCYYCVSGVPKP--DEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHIT 563
            +L+    E V+++FA I NF+     +       + +  LN++   FD+        +  +IK +G  Y   SG+     D+    H +   +  + ++  +  +   +  N  M+IG++ G + +G+IG +K Q+DIW   V +A++M+STG P  + +T
Sbjct: 1065 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRVLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT 1225          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|122065123|sp|P84309.2|ADCY5_MOUSE (RecName: Full=Adenylate cyclase type 5; AltName: Full=ATP pyrophosphate-lyase 5; AltName: Full=Adenylate cyclase type V; AltName: Full=Adenylyl cyclase 5)

HSP 1 Score: 251.136 bits (640), Expect = 1.442e-66
Identity = 171/550 (31.09%), Postives = 266/550 (48.36%), Query Frame = 0

Query:  251 SLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEPIPPID-DTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVILTGLLPCLWVSY 799
            +++ +  IY  LP+  ++          V+   + LAI L T + +    +KQL+++++ +   N +GV   Y  E++ R+ F + R CI      + E +Q+                   E LLLS++P H+   ++  I     DM            ++++ K +NVSILFADI  FT L +  T ++LV TLN+LF  FD  A  N C+RIKILGDCYYCVSG+P   E + +HA  CVEMG+ MI+ I +VR    VNV+MR+G+H+G +  G++G++KWQFD+WS DV +AN ME+ GK G +HIT+ T   L+  Y  EP    D +  L+++ I TFLI    +K  +++   A ++      + +S   N    G      +   G+ VS         E KR   E          DPK      D   ++  N      +F+   I+    R  D+ L  E +    L FR+   EK Y K+ D  F  Y+    ++   + I  +     PH +    + L   +L  L+  + V Y
Sbjct:  333 TVFFIYTIYTLLPVRMRAAVLS-----GVLLSALHLAISLHT-NSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQ-------------------ERLLLSVLPRHVAMEMKADINAKQEDMM---------FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP---EARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGDRNAYLKEHSIETFLILSCTQKRKEEKAMIAKMN----RQRTNSIGHNPPHWGAERPFYNHLGGNQVS--------KEMKRMGFE----------DPK------DKNAQESANPEDEVDEFLGRAIDA---RSIDR-LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVF--LFICFVQITIVPHSLFMLSFYLSCFLLLALVVFVSVIY 811          

HSP 2 Score: 177.948 bits (450), Expect = 1.149e-43
Identity = 115/284 (40.49%), Postives = 159/284 (55.99%), Query Frame = 0

Query:  830 KRINESLLARSTIFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDT--EYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGH-NARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVD 1110
            K +   +++   + L L A   E   RLDF WK Q   E+E     +  N  LL NILP  VA  +++  R    LY +S E VAVMFASI  + + + +++   E V  L  LN II+ FD+++  D  F ++EKIK I STYMAASGL                 D+ G  + + +A FA  +M ++    I E   + FQ++IGL+ G V+AGV+GA+KP YDIWGNTVNVASRMD TG   +IQV   M +VL A       R  + VKGKG+M  +F++
Sbjct:  988 KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDR-FRQLEKIKTIGSTYMAASGLNDS------------TYDKAGKTHIKAIADFAMKLMDQMK--YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1256          

HSP 3 Score: 74.3294 bits (181), Expect = 6.051e-12
Identity = 41/161 (25.47%), Postives = 80/161 (49.69%), Query Frame = 0

Query:  412 QLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAA---EINKCMRIKILGDCYYCVSGVPKP--DEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHIT 563
            +L+    E V+++FA I NF+     +       + +  LN++   FD+        +  +IK +G  Y   SG+     D+    H +   +  + ++  +  +   +  N  M+IG++ G + +G+IG +K Q+DIW   V +A++M+STG P  + +T
Sbjct: 1062 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKAIADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT 1222          

HSP 4 Score: 74.3294 bits (181), Expect = 6.259e-12
Identity = 56/233 (24.03%), Postives = 104/233 (44.64%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPG------TLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPES 1078
            E   R  FQ  R+    +  +         LL ++LP HVA    ++  +         +Y + +++V+++FA I  +  L ++   + +  + TLN + + FDKL   +H      +IK++   Y   SGL   R                  +A         M+  +S ++   GVN    +R+G+  G+V  GV+G +K  +D+W N V +A+ M+  G  G+I + ++
Sbjct:  402 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL--VMTLNELFARFDKLAAENHCL----RIKILGDCYYCVSGLPEAR----------------ADHAHCCVEMGMDMIEAISLVREVTGVN--VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKA 610          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|2833201|sp|Q04400.2|ADCY5_RAT (RecName: Full=Adenylate cyclase type 5; AltName: Full=ATP pyrophosphate-lyase 5; AltName: Full=Adenylate cyclase type V; AltName: Full=Adenylyl cyclase 5)

HSP 1 Score: 251.136 bits (640), Expect = 1.520e-66
Identity = 190/678 (28.02%), Postives = 308/678 (45.43%), Query Frame = 0

Query:  137 YLTERFQGKQLEGIYKRYEQRTQIGTFT--------------TYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSLQLNKPLLPNDNGTSSIYSEDAFFSEFIPESTPTGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEP-IPPIDDTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVILTGLLPCLWVSY 799
            + +++F   +LE +Y+RY  R    + T               +   +  L V Y+  +A          VG+++  ++  N+     D+   + Y+  A     +      G   P+    ++    +++ +  IY  LP+  ++          V+   + LAI L T   +    +KQL+++++ +   N +GV   Y  E++ R+ F + R CI      + E +Q+                   E LLLS++P H+   ++  I     DM            ++++ K +NVSILFADI  FT L +  T ++LV TLN+LF  FD  A  N C+RIKILGDCYYCVSG+P   E + +HA  CVEMG+ MI+ I  VR    VNV+MR+G+H+G +  G++G++KWQFD+WS DV +AN ME+ GK G +HIT+ T   L+  Y  EP      +  L+++ I TFLI    +K  +++   A ++      + +S   N    G      +   G+ VS         E KR   E          DPK      D   ++  N      +F+   I+    R  D+ L  E +    L FR+   EK Y K+ D  F  Y+    ++   + I  +     PH +    + L   +L  L+  + V Y
Sbjct:  217 FRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAAA--------VGVILIMAVLCNRAAFHQDHMGLACYALIAV----VLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLS-----GVLLSALHLAISLHTNAQDQF-LLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQ-------------------ERLLLSVLPRHVAMEMKADINAKQEDMM---------FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP---EARADHAHCCVEMGMDMIEAISSVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN----RQRTNSIGHNPPHWGAERPFYNHLGGNQVS--------KEMKRMGFE----------DPK------DKNAQESANPEDEVDEFLGRAIDA---RSIDR-LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVF--LFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIY 811          

HSP 2 Score: 178.333 bits (451), Expect = 7.297e-44
Identity = 116/284 (40.85%), Postives = 159/284 (55.99%), Query Frame = 0

Query:  830 KRINESLLARSTIFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDT--EYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGH-NARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVD 1110
            K +   +++   + L L A   E   RLDF WK Q   E+E     +  N  LL NILP  VA  +++  R    LY +S E VAVMFASI  + + + +++   E V  L  LN II+ FD+++  D  F ++EKIK I STYMAASGL                 D+ G  + + LA FA  +M ++    I E   + FQ++IGL+ G V+AGV+GA+KP YDIWGNTVNVASRMD TG   +IQV   M +VL A       R  + VKGKG+M  +F++
Sbjct:  988 KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDR-FRQLEKIKTIGSTYMAASGLNDS------------TYDKAGKTHIKALADFAMKLMDQMK--YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1256          

HSP 3 Score: 75.0998 bits (183), Expect = 3.674e-12
Identity = 56/233 (24.03%), Postives = 104/233 (44.64%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPG------TLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPES 1078
            E   R  FQ  R+    +  +         LL ++LP HVA    ++  +         +Y + +++V+++FA I  +  L ++   + +  + TLN + + FDKL   +H      +IK++   Y   SGL   R                  +A         M+  +S ++   GVN    +R+G+  G+V  GV+G +K  +D+W N V +A+ M+  G  G+I + ++
Sbjct:  402 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL--VMTLNELFARFDKLAAENHCL----RIKILGDCYYCVSGLPEAR----------------ADHAHCCVEMGMDMIEAISSVREVTGVN--VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKA 610          

HSP 4 Score: 74.3294 bits (181), Expect = 6.312e-12
Identity = 41/161 (25.47%), Postives = 80/161 (49.69%), Query Frame = 0

Query:  412 QLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAA---EINKCMRIKILGDCYYCVSGVPKP--DEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHIT 563
            +L+    E V+++FA I NF+     +       + +  LN++   FD+        +  +IK +G  Y   SG+     D+    H +   +  + ++  +  +   +  N  M+IG++ G + +G+IG +K Q+DIW   V +A++M+STG P  + +T
Sbjct: 1062 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT 1222          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|118572617|sp|Q08462.5|ADCY2_HUMAN (RecName: Full=Adenylate cyclase type 2; AltName: Full=ATP pyrophosphate-lyase 2; AltName: Full=Adenylate cyclase type II; AltName: Full=Adenylyl cyclase 2)

HSP 1 Score: 249.21 bits (635), Expect = 2.311e-66
Identity = 175/531 (32.96%), Postives = 267/531 (50.28%), Query Frame = 0

Query:  252 LYNLLVIYLFLPIPKKSVAFGFGIAVSVICV---TMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEPI-PPIDDTLLRDNDIHT-FLIYP-AHRKVLDQRQRPA-SLDGLDQPNKYSSTR--RNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYE----DLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLT 769
            L+ + V+Y  LP   +       I  SV+     T+ L++ LS         V Q+LA+++ ++  N  G Y +++ E+ +++ + D   CI +  KL++E+ Q+                   E LLLS++PAHI   ++  I + +   +            L++ +  NVSIL+ADI  FT L +  +  +LV  LN+LFG FD  A+ N+CMRIKILGDCYYCVSG+P      PNHA+NCV+MGL M + I  VR A  V+++MR+GVH+G +  G+IG++KWQ+D+WS DV +AN ME+ G PG VHI+  T   L+  Y  E     I D  L+ + + T F+I P   R+      RP  +LDG         TR   + G A   + L    R SM +                E+G I   +      + + ++L   S  K+F+  L    + M   I+ +  +K  QWL  E+I    L+F +K  EK Y     P FKYY+    +I   + I+ +L 
Sbjct:  141 LFIIFVVYTMLPFNMRD-----AIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ-------------------ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPI---SLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLH--HRDSMTT----------------ENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEEL---NERMIQAIDGINAQK--QWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILV 621          

HSP 2 Score: 206.453 bits (524), Expect = 8.924e-53
Identity = 123/275 (44.73%), Postives = 168/275 (61.09%), Query Frame = 0

Query:  842 IFLLLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTK--IDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQ--PGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVDID 1112
            I LL+    +EY  RLDF WK + K E+E   + +  N +LL N+LP HVA+ +++ +     LY +SY+ V VMFASIP + + +T+  ++ E +  L  LN II+ FD LL     F+ +EKIK I STYMAA+GL   P ++ S E        + Q  +   +  FA A++ KL  +  K   ND F+LR+G++ G VIAGV+GAQKP YDIWGNTVNVASRMD TG   KIQV E  + VL     +CT R  I VKGKG +K +FV+ +
Sbjct:  815 ITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLL-SKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEP-------ERQYMHIGTMVEFAFALVGKLDAIN-KHSFND-FKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTE 1079          

HSP 3 Score: 77.0258 bits (188), Expect = 8.461e-13
Identity = 62/253 (24.51%), Postives = 118/253 (46.64%), Query Frame = 0

Query:  340 IDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEK----LVETLNDLFGSFDD---AAEINKCMRIKILGDCYYCVSG---VPKPD-----EEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQL-SPKYLC 576
            +D  +K K+++E+E            +++      LL +++PAH+ E    R       ++N         ++L+    + V ++FA I +F    T   V K     +  LN++   FDD     + +   +IK +G  Y   +G   VP  +     E +  H    VE   A++  +  +   +  +  +R+G++ G + +G+IG +K Q+DIW   V +A++M+STG    + +TE+T + L +  Y C
Sbjct:  830 LDFLWKNKFKKERE----------EIETMENLNRVLLENVLPAHVAEHFLAR------SLKN---------EELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTC 1057          

HSP 4 Score: 58.5362 bits (140), Expect = 3.607e-7
Identity = 60/270 (22.22%), Postives = 111/270 (41.11%), Query Frame = 0

Query:  836 LLARSTIFLL--LCALMHEYMYRLDFQWKRQ-----LKSEQESAASTKLANNLLLRNILPHHVADLY---------------ISNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVL 1083
            +LA   IF+   L    H+++  L  Q   Q     +KS  +     +    LLL ++LP H+A                  + N  +   LY + + +V++++A I  +  L +      +  +  LN +   FD++       N+  +IK++   Y   SGL              + L     N     +    M   + +++   GV+    +R+G+  G V+ GV+G QK  YD+W + V +A+ M+  G  G++ +     E L
Sbjct:  191 ILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLL-SLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHM--LNELFGKFDQI----AKENECMRIKILGDCYYCVSGLP-------------ISLPNHAKNC---VKMGLDMCEAIKKVRDATGVD--INMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHL 435          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|68067621|sp|P32870.2|CYA1_DROME (RecName: Full=Ca(2+)/calmodulin-responsive adenylate cyclase; AltName: Full=ATP pyrophosphate-lyase; AltName: Full=Protein rutabaga)

HSP 1 Score: 251.906 bits (642), Expect = 2.930e-66
Identity = 172/511 (33.66%), Postives = 262/511 (51.27%), Query Frame = 0

Query:  130 GRAWNLTYLTERFQGKQLEGIYKRYEQRTQ-------IGTFTTYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSLQLNKPLLPNDNGTSSIYSEDAFFSEFIPESTPT-GDDKP--EKALTAKIPIMSLYNLLVIYLFLPIP-KKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEPIPPID-DTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRR 628
            GR  N    T RF+  +LE +Y+RY  + Q       +       G+ A LS+ +         F  AI  GL     + L   ++ + +  +  Y    F +     S PT G   P   K + A+     ++ + + Y  +P+   ++VAFG  +    I +T++   ++ T      E+  QL+A+IV ++ +N  G+ V  + E   RR FLD R CI +  +++ E E+                   LE LLLS++P H+   ++  I   V    +R+ ++          K ENVSILFADI  FT L++  + ++LV  LN+LFG FD  A  N C+RIKILGDCYYCVSG+P+P   + +HA+  VEMGL MI  I  V  A +V ++MR+G+HTG +  G++G++KWQFD+WS DV +AN MES G+PG VH+T  T   LS +Y  E     +  + LRD+ + TF I P        R++P  L+ L   +   S R+
Sbjct:   10 GRPLN----TLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFN-AIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVY---KIFTDALRYLEY-NQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEK-------------------LERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQ----------KHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEP---RKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPP-----PHRRKPLMLNTLGVRSAIGSRRK 474          

HSP 2 Score: 174.481 bits (441), Expect = 2.019e-42
Identity = 115/296 (38.85%), Postives = 161/296 (54.39%), Query Frame = 0

Query:  831 RINESL------LARSTIFLLLCALMH----EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYI-SNNRSPGTLYSESYEHVAVMFASIPKYMDLFTKID--TEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRK----GSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFV 1109
            R+N S+      LAR  IF++   L+H    E   RLDF W+ Q   E++     + +N  +L N+LP HVA  ++ +  R+   LY +SY  V V+FAS+P + + +T++D   + +  L  LN II+ FD+LL  D  F  I+KIK + STYMA  GL P  K        + RH   L E          +  AM   L E+      N  F LR+G++ G V+AGV+GA+KP YDIWGNTVNVASRMD TG  G  QV + + + L+  +     R  I VKGKG M  +F+
Sbjct:  870 RVNASIPLHLISLARIAIFMI-AILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKED-RFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIE----------YVKAMRHSLQEINSHSYNN--FMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151          

HSP 3 Score: 82.0333 bits (201), Expect = 3.336e-14
Identity = 54/205 (26.34%), Postives = 101/205 (49.27%), Query Frame = 0

Query:  375 LLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVE----KLVETLNDLFGSFDDAAEINKCM---RIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHA-------NNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQ 565
            +L +++PAH+          H  D Q R  +E      L+      V ++FA + NF    T M       + +  LN++   FD+  + ++     +IK +G  Y  V G+    + +PN   +      A+I+++  +RH+       +  N  +R+G++ G + +G+IG +K Q+DIW   V +A++M+STG PG   +T++
Sbjct:  930 ILHNLLPAHVAA--------HFLDAQFRNNME------LYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQE 1120          

HSP 4 Score: 76.2554 bits (186), Expect = 1.680e-12
Identity = 78/349 (22.35%), Postives = 150/349 (42.98%), Query Frame = 0

Query:  779 GEYTLIFVILTG--LLPC-LWVSYLWD-QIIDPHYDMEQIQVPKDRLLKFFYNKAKRINESLLARSTIFL------LLCALMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGT-----LYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQ-NVSCTYRDE--IFVKGKGKMKVFFV 1109
            G + ++FV+     ++P  +W +  +   +   H  +   ++  D L    YN+       L+A   IF+      L+  +M E   R  F   R   + +            LL ++LP HVA    ++  SP       +Y + +E+V+++FA I  +  L ++   + +  L  LN +   FD+L   +H      +IK++   Y   SGL   RK                 +A+        M+  ++   + E  +    +R+G+  G+V+ GV+G +K  +D+W N V +A+ M+  G  G++ V  +  + L  +  V   + DE   +++  G +  FF+
Sbjct:  132 GVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQ-------LIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRL--LNELFGRFDQLAHDNHCL----RIKILGDCYYCVSGLPEPRKD----------------HAKCAVEMGLDMIDAIAT--VVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHG-VDTFFI 448          

BLAST of adenylate cyclase type 8 isoform x2 vs. SwissProt
Match: gi|74948641|sp|Q9VW60.3|ADCY2_DROME (RecName: Full=Adenylate cyclase type 2; AltName: Full=ATP pyrophosphate-lyase 2; AltName: Full=Adenylyl cyclase 76E)

HSP 1 Score: 250.366 bits (638), Expect = 3.323e-66
Identity = 168/488 (34.43%), Postives = 245/488 (50.20%), Query Frame = 0

Query:  129 DGRAWNLTYLTERFQGKQLEGI-----YKRYEQRTQIGTFTTYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSL-------QLNKPLLPNDNGTSSIYSEDAFFSEFIPESTPTGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRL----TVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEPIPPID-DTLLRDNDIHTFLIYP 599
            D  + +L  L+E+  G   E I     Y RY QR +   F +  GL   L    +  I      Q  +   L+V  +L        L  P + +    +  ++    FS     +  TGD+       A +P+ +L+  L I+  LPI     ++   + +++    + +   + T  D     +  L  +IV   + +  G+Y R + +    R     R  I+   KL+ E EQ+                   E LLLS+IPA+I   V++ I   + D   R     +       +LH+ +  NV+ILFADI NFTPL++++T   LV+TLNDLFG FD  A+ N+C+RIKILGDCYYCVSG+P     +P HA NCV MGL MI  I  VR A  +NVDMRIG+HTG +  G++G++KWQFD+WS DV +AN MES G  G VHIT+QT   L  K+  E     + D  L D+ + ++LI P
Sbjct:   44 DALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLFRS--GLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVTTFS-LGTIAAITGDE------LAPLPMYALF--LCIHSMLPI-----SWPVSVVLALFMTAIHIVYRIGTSPDYAPN-LPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQ-------------------EQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPI---SRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVP 492          

HSP 2 Score: 219.935 bits (559), Expect = 1.019e-56
Identity = 127/261 (48.66%), Postives = 162/261 (62.07%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKYMDLF--TKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRK-GSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFV 1109
            EY+ R DF WK +LK EQE   + +  N +LL NILP HVA  ++   RS   LY ESY  VAVMFASIP Y + +  T ++ + +  L  LN II  FDKLLL    F+ IEKIK I+STYM ASGL+PG++ G+ +  R       + HN  IL  FA A+M  L  +  +E     F+LRIGL+ G VIAGV+GAQKP YDIW NTVNVASRMD  G  G++Q  E+ A++LM     C  R   +VKGKG +  +FV
Sbjct: 1049 EYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERST-ELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLL-KPKFSGIEKIKTIASTYMCASGLRPGKEDGATDEKR------TEEHNVVILVEFAIALMSILDSIN-RESFQR-FRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFV 1299          

HSP 3 Score: 73.559 bits (179), Expect = 1.224e-11
Identity = 69/269 (25.65%), Postives = 116/269 (43.12%), Query Frame = 0

Query:  325 GEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEK----LVETLNDLFGSFDD---AAEINKCMRIKILGDCYYCVSGVPKPDE-----EKPNHAENCV---EMGLAMIKHIGVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQT-KVQLSPKYLCE 577
            GE   R  FL K        KLK E+E+             +++    + LL +I+PAH+          H   ++           +L+      V+++FA I N+        V K     +  LN++   FD      + +   +IK +   Y C SG+    E     EK     N V   E  +A++  +  +   +     +RIG++ G + +G+IG +K Q+DIWS  V +A++M+S G  G +  TE T K+ ++  Y CE
Sbjct: 1048 GEYVARTDFLWKA-------KLKVEQEE------------VETMRGINKILLENILPAHVAT--------HFLHLERS--------TELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATDEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECE 1281          

HSP 4 Score: 58.5362 bits (140), Expect = 4.658e-7
Identity = 41/179 (22.91%), Postives = 81/179 (45.25%), Query Frame = 0

Query:  905 LYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVL 1083
            L+ + + +V ++FA I  +  L + +    +  + TLN +   FD++       N+  +IK++   Y   SGL   R       +H       G            M+  +  ++   G+N    +RIG+  G V+ GV+G +K  +D+W + V +A+ M+  G  G++ + +   + L
Sbjct:  308 LHVQRHTNVTILFADIVNFTPLSSSLTASDL--VKTLNDLFGRFDQI----AQENQCLRIKILGDCYYCVSGLPISRP------QHATNCVNMGLQ----------MIDAIRHVREATGIN--VDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFL 462          

BLAST of adenylate cyclase type 8 isoform x2 vs. nr
Match: gi|746871128|ref|XP_011066779.1| (PREDICTED: adenylate cyclase type 2 isoform X1 [Acromyrmex echinatior])

HSP 1 Score: 404.831 bits (1039), Expect = 1.029e-116
Identity = 250/759 (32.94%), Postives = 413/759 (54.41%), Query Frame = 0

Query:  129 DGRAWNLTYLTERFQGKQLEGIYKRYEQRTQIGTFTTYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSL-QLNKPLLPNDNGTSSIYSEDAFFSEFIPES------------------TPTGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEP---KPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVR----HANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQT-KVQLSPKYLCEPIPPIDDTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNS--GVAGDLSALA-SPRRGSMVSSASGH---IRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLL-TEKHP--HLVLWGEYTLIFVILTGLLPCLWVSYLWDQIIDPHYDME-QIQVPKDRLLKFFYNKAKRINESLLARSTIFLLLCALM 850
            D   W  + L ++F+ K LE +Y  Y +R Q G  + ++ LQ  L   Y   + +T   +E + + +VV+  +  L  P++     +  I +++ +    +                     T   D  P +      P  + ++LL  Y+FLPI K S A   G+  S +C    L+I     ++ T++++ ++++D ++++ +N +G+Y R++ E+ +RR FLD+R C+++T +L YE++QE                   E L  SI+P HI   ++K  R+    ++      P   +P   L +   +NVSIL+AD+ NF+ LT T+ + KLVETLNDLFGSFD+A+E +  +RIK LGDCYYCVSGVP P+ +   HA++CV++GL MIK I  VR      + V+V+MRIGVH+G I SGI+G  KWQ+D+WS+DV+IAN+ME TGKPG VH+T+QT  +  +  Y   P+  +DD +LR  +I ++LI P+                L + +  S TR NS   ++ D   L+ S      V   +G    I     + + M +   D +     +R++  MDS L+ +  +L +A   M + I ++PL K++QW + + INP FL FR  +WE P+++E DP+FK+YI  +  +L  MG + L+ T   P  HL     Y  + + L  L+P  W+ ++W++  DPH + E  +  P+++LL FFY  + ++  S L R+ ++L++  ++
Sbjct:   28 DFDEWTWSGLRKQFRYKNLEKLYTIYHRRIQYGYLSIFILLQLLLGFAYCLSLIITVGMKECL-LEIVVYCIVGALMCPMIALSFRSRHI-AKNTYLPIMLSWMIIVLLVVCDLTIPLFYVFTYAEDIPPIR------PAYATHSLLACYVFLPITKNSHALVLGLTAS-MCYLATLSI---ITYNNTSDYITKIISDAIYFMCVNALGLYFRFMNEVVIRRSFLDRRKCVESTLRLNYEKDQE-------------------EQLTRSILPQHIVAKIKKDFRDIFKFIEEHKKSPPPKGRPYSDLCVETHDNVSILYADVVNFSGLTVTLPIRKLVETLNDLFGSFDEASERHNVLRIKFLGDCYYCVSGVPTPNSQ---HAKSCVDLGLDMIKIINEVRTRVYRESGVDVNMRIGVHSGNIISGILGTNKWQYDVWSRDVVIANKMEQTGKPGKVHVTQQTLDLVNASDYNYIPVERLDDEVLRKYEIRSYLITPS----------------LPETSILSPTRENSLNTISPDTPTLSYSVSNKHYVKFNNGRTNTIISTNSRTRLMVNNQADVFAS-TYRRRTHFMDSCLRDYHLMLKAADAEMENAINQMPLSKWEQWSNWKHINPLFLTFRQWSWEIPFLREPDPVFKFYIGCSAFVLIFMGFMYLVPTFMLPQWHLRTLVGYFSVLMFLFALMPLTWMHFVWNRCKDPHDEHEGHVPHPRNKLLYFFYQTSVKVVWSALLRTILYLVITIML 735          

HSP 2 Score: 230.335 bits (586), Expect = 1.103e-57
Identity = 130/270 (48.15%), Postives = 170/270 (62.96%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSP-GTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHN--ARILARFAAAMMRKLSELQIKE-GVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVDIDEVGVI 1117
            EY+ RLD+QWKRQL  EQ+ A  T+ AN LLLRNILP HVA+ Y++ NR+     Y E++ +VAVMFAS+       T++       L+ LN II  FDKLL       +IEKIKV  +TYMAA GL   R+GS     H  + DE  ++   +++A+FA  MM  L ++  +    +   +LRIG+S G+V AGVVGAQKPLYDIWG+ VN+ASRMD TG  GKIQV    A VL  Q V C  R E +VK KG++  +FV IDE G++
Sbjct:  860 EYLSRLDYQWKRQLTKEQDEAFHTRNANKLLLRNILPEHVAEFYLNMNRTEENEPYHEAHNNVAVMFASL-------TELSIVESNILSDLNEIICEFDKLLFEPSFMCRIEKIKVAGTTYMAACGLDAYRRGS----MHSTESDENCNDNVVKVMAQFAVHMMSVLDKMNARSFTTSKPHKLRIGISHGEVTAGVVGAQKPLYDIWGDAVNMASRMDTTGLPGKIQVTADTAAVLEQQGVKCHLRGETYVKPKGEVTTYFVGIDEKGIL 1118          

BLAST of adenylate cyclase type 8 isoform x2 vs. nr
Match: gi|1068418276|ref|XP_018054428.1| (PREDICTED: adenylate cyclase type 2-like isoform X1 [Atta colombica])

HSP 1 Score: 404.831 bits (1039), Expect = 1.238e-116
Identity = 244/756 (32.28%), Postives = 413/756 (54.63%), Query Frame = 0

Query:  133 WNLTYLTERFQGKQLEGIYKRYEQRTQIGTFTTYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSL-QLNKPLLPNDNGTSSIYSEDAFFSEFIPES------------------TPTGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEP---KPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVR----HANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQT-KVQLSPKYLCEPIPPIDDTLLRDNDIHTFLIYPA--HRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLL--------TEKHPHLVLWGEYTLIFVILTGLLPCLWVSYLWDQIIDPHYDME-QIQVPKDRLLKFFYNKAKRINESLLARSTIFLLLCALM 850
            W  + L ++F+ K LE +Y  Y +R Q G  + ++ LQ  L   Y   + +T   +E + + +VV+  +  L  P++     +  I +++ +    +                     T T D  P +      P  + ++LL  Y+FLPI K S A   G+  S+     +LA      ++ T++++ ++++D ++++ +N +G+Y R++ E+ +RR FLD+R C+++T +L YE++QE                   E L  SI+P HI   ++K  R+    ++      P   +P   L +   +NVSIL+AD+ NF+ LT T+ + KLVETLNDLFGSFD+A+E +  +RIK LGDCYYCVSGVP P+ +   HA++CV++GL MIK I  VR      + V+V+MRIGVH+G I SGI+G  KWQ+D+WS+DV+IAN+ME TGKPG VH+T+QT  +  +  Y   P+  +DD +LR  +I ++LI P+     +L     P   + L+  +  +ST   S          + R  +++S++S        + + M +   D +     +R++  MDS L+ +  +L +A   M + I ++PL K++QW + + INP FL FR  +WE P+++E DP+FK+YI  +  +L  MG + L+          +  HL     Y  + + L  L+P  W+ ++W++  DPH + E  +  P+++LL FFY  + ++  S L R+ ++L++  ++
Sbjct:   42 WTWSGLRKQFRYKNLEKLYTIYHRRIQYGYLSIFILLQLLLGFAYCLSLIITVGMKECL-LEIVVYCIVGALMCPMIALSFRSRHI-AKNTYLPIMLSWMIIVLLVVCDLTIPLFYVFTYTEDIPPIR------PAYATHSLLACYVFLPITKNSHALVLGLTASMC----YLATLSVITYNNTSDYITKIVSDAIYFMCVNALGLYFRFMNEVVIRRSFLDRRKCVESTLRLNYEKDQE-------------------EQLTRSILPQHIVAKIKKDFRDIFKFIEEHKKSPPPKGRPYCDLCVETHDNVSILYADVVNFSGLTITLPIRKLVETLNDLFGSFDEASERHNVLRIKFLGDCYYCVSGVPTPNSQ---HAKSCVDLGLDMIKIINEVRTRVYRESGVDVNMRIGVHSGNIISGILGTNKWQYDVWSRDVVIANKMEQTGKPGKVHVTQQTLDLVNASDYNYIPVERLDDEVLRKYEIRSYLITPSLPETPILS----PTRENSLNTISPDTSTLSYSMSNKHYVKFNNGRTNTIISTSS--------RTRLMVNNQADVFAS-TYRRRTHFMDSCLRDYHLMLKAADAEMENAINQMPLSKWEQWSNWKHINPLFLTFRQWSWEIPFLREPDPVFKFYIGCSAFVLIFMGFMYLVPTFMLPQYAYQKWHLRTLVGYFSVLMFLFALMPLTWMHFVWNRCKDPHDEHEGHVPHPRNKLLYFFYQTSVKVVWSALLRTILYLVITIML 750          

HSP 2 Score: 228.409 bits (581), Expect = 4.801e-57
Identity = 130/270 (48.15%), Postives = 169/270 (62.59%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSP-GTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHN--ARILARFAAAMMRKLSELQIKE-GVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVDIDEVGVI 1117
            EY+ RLD+QWKRQL  EQ+ A  T+ AN LLLRNILP HVA+ Y++ NR+     Y ES+ +VAVMFAS+       T++       L+ LN II  FDKLL       +IEKIKV  +TYMAA GL   R+GS     H  + DE   +   +++A+FA  MM  L ++  +    +   +LRIG+S G+V AGVVGAQKPLYDIWG+ VN+ASRMD TG  GKIQV    A VL  Q V C  R E +VK KG++  +FV I+E G++
Sbjct:  875 EYLSRLDYQWKRQLTKEQDEAFHTRNANKLLLRNILPEHVAEFYLNMNRTEENEPYHESHNNVAVMFASL-------TELSIVESNILSDLNEIICEFDKLLFEPSFMCRIEKIKVAGTTYMAACGLDAHRRGS----MHSTESDENCSDNVVKVMAQFAVQMMSVLDKMNARSFTTSKPHKLRIGISHGEVTAGVVGAQKPLYDIWGDAVNMASRMDTTGLPGKIQVTADTAAVLEQQGVKCHLRGETYVKPKGEVTTYFVGINEKGML 1133          

BLAST of adenylate cyclase type 8 isoform x2 vs. nr
Match: gi|1227989525|ref|XP_021926486.1| (adenylate cyclase type 2 isoform X1 [Zootermopsis nevadensis] >gi|1227989527|ref|XP_021926487.1| adenylate cyclase type 2 isoform X1 [Zootermopsis nevadensis])

HSP 1 Score: 404.445 bits (1038), Expect = 1.239e-116
Identity = 253/756 (33.47%), Postives = 392/756 (51.85%), Query Frame = 0

Query:  109 RRGSTAFNSIIQSSDTDPGYDGRAWNLTYLTERFQGKQLEGIYKRYEQRTQIGTFTTYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSLQLNKPLL------------PNDNGTSSIYSEDAFFSEFIPESTPTGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHIGVVRHANNV--NVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQLSPKYLCEP-IPPIDDTLLRDNDIHTFLIYPA--HRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLLTEKHPHLVLWGEYTLIFVILTGLLPCLWVSYLWDQIIDPHYDMEQIQVPKDRLLKFFYNKAKRINESLLARSTIFLLLC 847
            R  S   N + ++ +T P  D R W   YL  +F+ K LE +Y +Y QR  +G F+ ++ LQ+ LS+ +   + +    +  +   L+   ++ L  PL+            P  +   S +         +        ++ E A   + P  + + LLV Y+FLP+ +   AF  G+ V++  +T+   +     + +  E  ++L +D V++L +N +G+Y R + E+ +RR FLD+R C+++  K++YE++QE                   E+L+LSIIP HI + VRK I+  +  +   L    KP   +++ + +NVSIL+AD+  +  LT ++ V KLVETLN+LFG FD+A+E    +RIK LGDCYYCVSGVP   +  PNHA+NCV++GL MI  I  VR    +   +DMRIG+H+G I SG++G+ KWQ+D+WS+DVIIAN ME  GKPG VHIT++T   L   Y C P      + +L+  +I TF I PA  H +     +RP               RR S  AG    L S R  S V  +            N+  GS         +R+   MD  L K+Q  L  A + M D I+ + +  YD+WL  E INP  L F +  WE P++K+ DPLFK+Y+     +L  M  I  L     H + W  Y +   ++  LLP  W  Y+W ++ DPH + + I  P+++ L   Y  + ++  S   R+ I+L++C
Sbjct:   19 RHVSQVSNYLRETLNTQPT-DDRNWWWGYLRRQFRLKNLEELYLKYLQRLHLGYFSVFVVLQSLLSLSHATILWI---IEAPLPDALLYCVAMALCWPLVFVVFKERLVHTFPWISLLVSCFVVVLLIIVDLGIPLYHASNRTEAADVLR-PAYTTHTLLVCYVFLPLTENIQAFILGLVVTLCHLTVLGTVT----YYKKREIYERLASDTVYFLCVNGLGLYFRLMSEVAIRRTFLDRRACLESNSKVEYEKQQE-------------------ENLMLSIIPRHIIDDVRKDIQSLIQQINAPL--RKKPFSDMYVTEHDNVSILYADVVKYAQLTVSLPVNKLVETLNELFGRFDEASEERGVLRIKFLGDCYYCVSGVP---DYNPNHAKNCVDLGLDMIAIIKEVREERKLKETLDMRIGIHSGKILSGLLGVCKWQYDVWSRDVIIANNMEQAGKPGRVHITKETLNLLGNNYRCIPGNGSTRNEVLQKYNIETFFIVPADKHSEERVTEERPL------------YNRRYS--AGGQRRLTSNRGPSQVRRSGT---------DNLAVGS---------RRRIAFMDDNLYKYQQTLKKADEQMADAIKNMHVGVYDRWLLRENINPFCLTFENMQWELPFLKQPDPLFKFYVGCALFVLLGMLTIQCLGLPSSHWMPWVGYGVSLGVIFMLLPLTWTHYMWTKLKDPHEEQDYIPEPRNKFLNLLYQASLKVVWSAGTRTAIYLVVC 709          

HSP 2 Score: 216.853 bits (551), Expect = 1.864e-53
Identity = 134/305 (43.93%), Postives = 176/305 (57.70%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSPGTLYSESYEHVAVMFASIPKY--MDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKM-KVFFVDIDEVGVIVTLNQGVSNDLE-----------EERKHEEKHGLTR 1142
            EYM RLD++WKRQL  EQE +++  + N +LL+NILP HVAD +++ NR    LY E Y+ VAVMFAS+ +Y   D      +  ++S+  LN II  FDKLL  D +  ++EKIKV   TYMAA GL PGR+ S          D   H   +L RFAA MM  L   +I      AF+LR+G+S GKV AGV+GAQKP YDIWG++VN+ASRM+ TG  GKIQV E+ A VL    + C  R  I VK    +   +FV  DE   ++ +     +D +           EER  EEK   T+
Sbjct:  835 EYMNRLDYKWKRQLSHEQEESSTMHMINKMLLQNILPVHVADWFLNTNRDHEELYHEEYDTVAVMFASLTEYALWDDNGLDGSNELSSIRLLNQIICDFDKLLF-DTSSLRVEKIKVAGWTYMAACGLDPGRRDSVNSINRSSFSD---HVVLVLTRFAAKMMGVLQ--KINRETFQAFKLRVGISHGKVTAGVIGAQKPHYDIWGHSVNMASRMESTGEPGKIQVTENTARVLQQLGIHCECRGAIKVKSITNLVTTYFVHFDENFQLIQVENVQDSDQDSVLEESEVRHCEERYTEEKQNNTK 1133          

HSP 3 Score: 76.2554 bits (186), Expect = 4.821e-10
Identity = 89/403 (22.08%), Postives = 162/403 (40.20%), Query Frame = 0

Query:  826 YNKAKRINESLLARSTIFL------LLCALMHEYMYRLDFQWKRQ-LKSEQESAASTKLANNLLLRNILPHHVAD-------LYISNNRSP------GTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSC-----TYRDEIFVKGKGKMKVFFVDIDEVGVIVTLNQGVSNDLEEERKHEEKHGLTRELT----KRRNRKKGQTSVKRESTN--SVGSGLNFNIDDPTTGKDHLDLPRVDEAHGSGLK 1197
            Y K + I E L + +  FL      L   LM E   R  F  +R  L+S  +     +   NL+L +I+P H+ D         I    +P        +Y   +++V++++A + KY  L   +    +    TLN +   FD+          + +IK +   Y   SG+                 D   ++A+        M+  + E++ +  + +   +RIG+  GK+++G++G  K  YD+W   V +A+ M+  G  G++ + +     L+  N  C     + R+E+    K  ++ FF+               ++   EER  EE+    R  +    +R    +G + V+R  T+  +VGS       D    K    L + DE     +K
Sbjct:  207 YYKKREIYERLASDTVYFLCVNGLGLYFRLMSEVAIRRTFLDRRACLESNSKVEYEKQQEENLML-SIIPRHIIDDVRKDIQSLIQQINAPLRKKPFSDMYVTEHDNVSILYADVVKYAQLTVSLPVNKLVE--TLNELFGRFDE----ASEERGVLRIKFLGDCYYCVSGVP----------------DYNPNHAKNCVDLGLDMIAIIKEVREERKLKETLDMRIGIHSGKILSGLLGVCKWQYDVWSRDVIIANNMEQAGKPGRVHITKETLN-LLGNNYRCIPGNGSTRNEVL--QKYNIETFFI-------------VPADKHSEERVTEERPLYNRRYSAGGQRRLTSNRGPSQVRRSGTDNLAVGSRRRIAFMDDNLYKYQQTLKKADEQMADAIK 570          

BLAST of adenylate cyclase type 8 isoform x2 vs. nr
Match: gi|805776982|ref|XP_012138136.1| (PREDICTED: adenylate cyclase type 2-like isoform X2 [Megachile rotundata])

HSP 1 Score: 403.29 bits (1035), Expect = 1.300e-116
Identity = 247/765 (32.29%), Postives = 411/765 (53.73%), Query Frame = 0

Query:  133 WNLTYLTERFQGKQLEGIYKRYEQRTQIGTFTTYLGLQAFLSVFYI----------GCI--AVTCRFQEAIDVGLVVHHSLQLNKPLLPNDNGTSSIYSEDAFFSEFIPE-STP-------TGDDKPEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPK--PIKQLHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHI----GVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQT-KVQLSPKYLCEPIPPIDDTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQPNKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDP---KRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILLL---TEKHPHLVLWGEYTLIFVILTGLLPCLWVSYLWDQIIDPHYDME-QIQVPKDRLLKFFYNKAKRINESLLARSTIFLLLCALMHEY-MYRLDFQWK 862
            W  + L ++F+ K LE ++  Y++R Q G  + ++ LQ  L   +            C+   V C    A+   ++   +L     L+  +N  S I S        I + + P        GD  P +      P  + + LL  Y+FLP+ +   AF  G+  + IC  + L++     +  T +F  +++ D ++++ +N +G+Y R++ E+ +RR FLD+R C+++T +L YE++QE                   E L  SI+P HI   ++K  R+    ++      PK  P   L + K +NVSIL+AD+ NF+ LT T+ V KLVETLNDLFGSFD+A+E +  +RIK LGDCYYCVSGVP P+ +   HA+NCV++GL MIK I      VR    V+V+MRIGVH+G I SGI+G  KWQ+D+WS+DV+IAN+ME TG+PG VH+T+QT  +  + +Y C P+  I+D +L+   I ++LI P+                 D P   +S    + ++ D   +A+       +  +     +  +     + +I+++ D+     +R++  MDS L+ +  +L +A   M + I+++PL K++QW   E INP FL F+   WE P++KE DPLFK+Y+ +   +L  MG+I L+   +    HL     Y++  + L  L+P +W+ + W++  DPH + E  +  P+++LL F Y  + ++  S   R+ ++L++  ++    M+ + F+ K
Sbjct:   31 WTWSSLRKQFKYKSLEKLFTVYQRRLQYGYLSLFVLLQLVLGATHCLILVTMVNIENCVPDVVVCSVMSALLCPVI---ALSFRSKLISRNNYLSVILSCLIVMLLVIGDLAVPLYYTLVSNGDVSPIR------PAYATHALLACYVFLPLTENLHAFILGVTAT-ICYLVTLSL---ITYRNTFDFSTKIITDTIYFVCVNGLGLYFRFMNEVVIRRSFLDRRKCVESTLRLNYEKDQE-------------------EQLTRSILPQHIAAKIKKDFRDIFKFIEEHKKPPPKGRPHNDLCVEKHDNVSILYADVVNFSGLTVTLPVRKLVETLNDLFGSFDEASERHNVLRIKFLGDCYYCVSGVPTPNSQ---HAKNCVDLGLDMIKIIKEVRARVRRECGVDVNMRIGVHSGNIISGILGANKWQYDVWSRDVVIANKMEQTGEPGKVHVTQQTLDLVDASEYDCVPVDVINDEILKKYGIRSYLITPSIPP--------------DAPISQNSENTLTVISPDTPPVANKHYVRFSNVRTS--NSSSSRNSRRLTPTINNHVDVFAGTYRRRTHFMDSCLRDYHLMLRAADAEMENAIKQMPLTKWEQWCRWEHINPLFLTFKKWNWEIPFLKEPDPLFKFYLSSAVFVLIFMGLIYLVPAASASEWHLSTTISYSVAILFLIALIPIVWMHFAWNRYKDPHDEHEGHVPHPRNKLLCFLYQTSVKVVWSTFLRTILYLVITIMLAACAMFDMIFECK 744          

HSP 2 Score: 219.55 bits (558), Expect = 1.918e-54
Identity = 126/265 (47.55%), Postives = 162/265 (61.13%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSP-GTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNA-RILARFAAAMMRKLSELQIKEGVN-DAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVDIDE 1113
            EY+ RLD+ WKRQL  EQ+ A  T+ AN LLLRNILP HVA+ Y++ NRS     Y E++ +VAVMFAS+       T +  +    L  LN II  FDKLL   +   +IEKIK+  +TYMAA GL+  R+ S    R     +    N  +++A+FA  MM  LS+L  +       ++LRIG+S G+V AGVVGAQKPLYDIWG+ VN+ASRMD TG  GKIQV    A VL  Q + C  R   +VK KG +  +FV IDE
Sbjct:  807 EYLSRLDYLWKRQLTEEQDEAFQTRNANKLLLRNILPEHVAEFYLNMNRSEENEPYHEAHNNVAVMFASL-------TDVSIDGRNVLMDLNEIICEFDKLLFEPYFLCRIEKIKIAGTTYMAACGLEASRRDS---MRSTESEESCSENVVKVMAQFAVEMMGVLSKLNGRSFYRCKPYKLRIGISHGEVTAGVVGAQKPLYDIWGDAVNMASRMDTTGVPGKIQVTAETAAVLEQQGIKCHLRGNTYVKPKGYVTTYFVGIDE 1061          

HSP 3 Score: 67.781 bits (164), Expect = 1.899e-7
Identity = 62/266 (23.31%), Postives = 116/266 (43.61%), Query Frame = 0

Query:  849 LMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVA--------DLY--ISNNRSP-------GTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGL-QPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEI 1096
             M+E + R  F  +R+           K     L R+ILP H+A        D++  I  ++ P         L  E +++V++++A +  +  L   +    +    TLN +  +FD+        + + +IK +   Y   SG+  P  + +      G+ +       +I+    A + R+        GV+    +RIG+  G +I+G++GA K  YD+W   V +A++M+ TG  GK+ V +   +++ A    C   D I
Sbjct:  228 FMNEVVIRRSFLDRRKCVESTLRLNYEKDQEEQLTRSILPQHIAAKIKKDFRDIFKFIEEHKKPPPKGRPHNDLCVEKHDNVSILYADVVNFSGLTVTLPVRKLVE--TLNDLFGSFDE----ASERHNVLRIKFLGDCYYCVSGVPTPNSQHAKNCVDLGLDM------IKIIKEVRARVRREC-------GVD--VNMRIGVHSGNIISGILGANKWQYDVWSRDVVIANKMEQTGEPGKVHVTQQTLDLVDASEYDCVPVDVI 472          

BLAST of adenylate cyclase type 8 isoform x2 vs. nr
Match: gi|970915386|ref|XP_015124090.1| (PREDICTED: adenylate cyclase type 2-like isoform X4 [Diachasma alloeum])

HSP 1 Score: 404.06 bits (1037), Expect = 1.554e-116
Identity = 250/743 (33.65%), Postives = 398/743 (53.57%), Query Frame = 0

Query:  133 WNLTYLTERFQGKQLEGIYKRYEQRTQIGTFTTYLGLQAFLSVFYIGCIAVTCRFQEAIDVGLVVHHSLQLNKPLLPNDNGTSSIYSED---AFFSEFIPESTPTGDDK--------PEKALTAKIPIMSLYNLLVIYLFLPIPKKSVAFGFGIAVSVICVTMFLAIELSTGHDETTEFVKQLLADIVFYLTLNFIGVYVRYVGEINMRRGFLDKRGCIDTTFKLKYEEEQEASAFNCPLKFRTDSLPTFLEHLLLSIIPAHITEPVRKRIREHVYDMQNRLTVEPKPIKQ--LHLAKQENVSILFADICNFTPLTTTMTVEKLVETLNDLFGSFDDAAEINKCMRIKILGDCYYCVSGVPKPDEEKPNHAENCVEMGLAMIKHI----GVVRHANNVNVDMRIGVHTGLIFSGIIGIKKWQFDIWSKDVIIANQMESTGKPGAVHITEQTKVQL-SPKYLCEPIPPIDDTLLRDNDIHTFLIYPAHRKVLDQRQRPASLDGLDQP---NKYSSTRRNSGVAGDLSALASPRRGSMVSSASGHIRRNEQKRKNMESGSIDDYEDLDPKRKSLLMDSGLKKFQNILASAGDFMRDEIEKLPLRKYDQWLHPEEINPAFLMFRDKTWEKPYIKENDPLFKYYILATFVILNSMGIILL---LTEKHPHLVLWGEYTLIFVILTGLLPCLWVSYLWDQIIDPHYDME-QIQVPKDRLLKFFYNKAKRINESLLARSTIFLLLCALM 850
            W  + L ++F+ K LE +Y  Y++R Q G  + ++ +Q  L + +   + +T     ++   +       L  P++     +  I  E       S  I      GD            K  TA  P  + + LL  Y+FLP+ +   AF  GI  + +C  M LA+     +    ++  +++AD +++  +N +G+Y R++ E+ +RR FLD+R C+++T +L YE++QE                   E L  SI+P H    ++K  R+    ++      PK  ++  L++    NVSIL+AD+ NF+ LT T+ V+KLVETLNDLFGSFD+A+E +  +RIK LGDCYYCVSGVP P+ +   HA++CV++GL MIK I      VR    V+++MRIGVH+G I SGI+G  KWQ+D+WS+DV+IAN+ME TG+PG VH+T+QT   L + +Y C P+  ++D  LR  +I ++LI P             S+ G   P   N  S+      V   +S     R  S+  S S    RN ++     +   D +     +R++  MDS LK +  +L +A   M D I+++PL K++QW   E INP FL F    WE P+++E DPLFK+++    ++L SMG I L   + +   HL     + L  + L  LLP  W+ ++W++  DPH + E  I  P+++LL F Y  + ++  S L R+T++L++  ++
Sbjct:   31 WTWSSLRKQFEYKNLEKLYTIYQRRLQNGYLSLFVLVQLVLGIAHCTVLIMTVEIHASLPDVVTWCIMGALLCPVIALSFRSKLIAKETYLPVVLSCVIVVLLVLGDLAVPFWYTLGTSKDTTAIRPAYATHVLLACYVFLPLTENLHAFILGITAT-LCYLMSLAL---ITYRNLPDYTARIIADAIYFACVNGLGLYFRFMNEVVIRRSFLDRRKCVESTLRLNYEKDQE-------------------EQLTRSILPQHFAAKIKKDFRDIFKFIEEHKKPPPKGRRRNDLYVETHNNVSILYADVVNFSGLTVTLPVKKLVETLNDLFGSFDEASERHNVLRIKFLGDCYYCVSGVPTPNAQ---HAKSCVDLGLDMIKIIKEVRARVRRECGVDINMRIGVHSGKIISGILGANKWQYDVWSRDVVIANKMEQTGQPGKVHVTQQTLNLLEAAQYDCVPVETLNDETLRKYNIKSYLITP-------------SIPG--SPVLQNSESNLTIADPVTPPVSNKHYVRWYSVRPSTSVGAARNTKRLTQTMNNHADVFAG-TFRRRTHFMDSCLKDYHLMLKAADAEMEDAIKQMPLSKWEQWSKWEPINPIFLTFSRLNWEIPFLREPDPLFKFFVGCAALVLLSMGFIFLAPAIIKSEWHLSTTVGFMLAMLFLIALLPLTWMHFVWNRCKDPHDEHEGHIPQPRNKLLHFMYQTSIKVVWSALLRTTLYLVITIML 731          

HSP 2 Score: 220.705 bits (561), Expect = 1.192e-54
Identity = 126/264 (47.73%), Postives = 164/264 (62.12%), Query Frame = 0

Query:  852 EYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVADLYISNNRSP-GTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGLQPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVN-DAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCTYRDEIFVKGKGKMKVFFVDIDE 1113
            EY+ RLD+QWKRQL  EQ+ A  T+ AN LLLRNILP HVAD Y++ NR+    LY E++++VAVMFAS+       T +  +    L  LN II  FDKLL       +IEKIK+  +TYMAA GL+  R+ S E        DE  H  +++A+FA  M+  L  L  +   N   ++LRIG+S G+V AGVVGAQKPLYDIWG+ VN+ASRMD TG  GKIQV    A VL    + C  R + +VK KG +  +F+ +DE
Sbjct:  855 EYLSRLDYQWKRQLTQEQDEAFHTRNANKLLLRNILPEHVADFYLNMNRTEEHELYHEAHDNVAVMFASL-------TDLSIDESNILIDLNEIICEFDKLLFEPCFVCRIEKIKIAGTTYMAACGLEARRRDSLE--NEDQYHDE--HVVKVMAQFAVRMLGILDRLNAETFPNCKPYKLRIGISHGEVTAGVVGAQKPLYDIWGDAVNMASRMDTTGVPGKIQVTTETATVLEQDGIKCNLRGKTWVKPKGLVTTYFIGVDE 1107          

HSP 3 Score: 72.4034 bits (176), Expect = 6.574e-9
Identity = 63/261 (24.14%), Postives = 115/261 (44.06%), Query Frame = 0

Query:  849 LMHEYMYRLDFQWKRQLKSEQESAASTKLANNLLLRNILPHHVA--------DLY--ISNNRSP-------GTLYSESYEHVAVMFASIPKYMDLFTKIDTEYVTSLTTLNTIISAFDKLLLVDHNFNKIEKIKVISSTYMAASGL-QPGRKGSGEIFRHGVKLDEQGHNARILARFAAAMMRKLSELQIKEGVNDAFQLRIGLSEGKVIAGVVGAQKPLYDIWGNTVNVASRMDYTGAEGKIQVPESMAEVLMAQNVSCT 1091
             M+E + R  F  +R+           K     L R+ILP H A        D++  I  ++ P         LY E++ +V++++A +  +  L   +  + +    TLN +  +FD+        + + +IK +   Y   SG+  P  + +      G+ +       +I+    A + R+        GV+    +RIG+  GK+I+G++GA K  YD+W   V +A++M+ TG  GK+ V +    +L A    C 
Sbjct:  228 FMNEVVIRRSFLDRRKCVESTLRLNYEKDQEEQLTRSILPQHFAAKIKKDFRDIFKFIEEHKKPPPKGRRRNDLYVETHNNVSILYADVVNFSGLTVTLPVKKLVE--TLNDLFGSFDE----ASERHNVLRIKFLGDCYYCVSGVPTPNAQHAKSCVDLGLDM------IKIIKEVRARVRREC-------GVD--INMRIGVHSGKIISGILGANKWQYDVWSRDVVIANKMEQTGQPGKVHVTQQTLNLLEAAQYDCV 467