neprilysin-2-like isoform x3, maker-scaffold75_size407189-snap-gene-3.15 (gene) Tigriopus kingsejongensis
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Overview
Associated RNAi Experiments
Nothing found Homology
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000007047 (supercontig:LSalAtl2s:LSalAtl2s3:1196101:1219563:1 gene:EMLSAG00000007047 transcript:EMLSAT00000007047 description:"maker-LSalAtl2s3-snap-gene-12.11") HSP 1 Score: 305.064 bits (780), Expect = 1.186e-91 Identity = 139/300 (46.33%), Postives = 199/300 (66.33%), Query Frame = 0
Query: 635 KDYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCK 934
K++K + + WMD++T +RA+ KL +I E I Y + I+ ++ LY+ L ++ +F+N S S W W +L + + W + A+VNAFYS + NSI PAGILQG F+N+NRP+Y+NYGSIG++IGHE+THGFDD G+Q D GNL +WWE +T ++F KA C + QY N+T +N+++ G + QGE IADNGG+ AY AY +W HG+E+ LPGL+ S+QLFW SAAN WC++ + +K + G H +RV FSN +EF++DFKCPLG+ MNP KC+
Sbjct: 364 KEFKKILQEITWMDEQTRTRAINKLAAIKEYIAYPEEIMKVENLEELYKGLKINNNTYFENEKSLSLWSYSYLWKKLREKIDKTDWKRHAEPAVVNAFYSSIENSIQFPAGILQGVFFNKNRPHYMNYGSIGWVIGHEITHGFDDRGRQSDSNGNLNDWWEMETKKKFLEKAQCIIWQYGNYTSKAVNVSLNGVNTQGENIADNGGLKEAYRAYVSWESVHGQENSLPGLNFNSRQLFWLSAANNWCSKFRPKVLKNRILTGYHSPGAFRVRGTFSNLKEFSQDFKCPLGTNMNPINKCE 663 HSP 2 Score: 115.161 bits (287), Expect = 1.654e-26 Identity = 100/436 (22.94%), Postives = 174/436 (39.91%), Query Frame = 0
Query: 58 LVTISALLAVFVVNTVLDGAIEDE--LGIRLRGGPEI----CQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLG---EPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFR 484
L+ I +L + +V ++ + +E LG + I C TP+C+ +A L+QNM+ I DD++ S+ S++ D++ ++R I + S + +QACM+ +E LGL+P+ LK + + G D Q LGL + L +G++++ V YY+Y +AVLLG E T LK +L FE+ LANA+ + + LYN M L ++ P +++ YVN+ P + +Y++WR + +N R ++ ++ + +GT +D+PRWK C+ A + +VG YV +F +AK + EMV + + F+
Sbjct: 47 LLCICGILVLLIVVMIILSIVRNERPLGPYPQPPAPIPHSKCTTPDCIASAHSLLQNMN------------------PESRIADDKTYKSQFSIIGDELDEQIRDILESNGTENDSLVFNQVRSIYQACMNEDSLEGLGLEPMLKELK-----------------------------------SLVMGFD----------------QASLGLSREYLVQGFESENVNYYYSYMQKVAVLLGASPEEAATQLKESLL----FEMKLANASLPKEERRNASKLYNPMKLIDVDDLMPGVNFTDYVNE-----------------------------------------PKRNVANYLLWRIASQGLFVLNKAAREISLEYRKNVTGTPADAPRWKKCVGAAGS-LGTVVGHLYVSKYFKEDAKHNMMEMVKYIKKEFK 367
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000001658 (supercontig:LSalAtl2s:LSalAtl2s128:1881693:1892323:1 gene:EMLSAG00000001658 transcript:EMLSAT00000001658 description:"maker-LSalAtl2s128-snap-gene-19.19") HSP 1 Score: 284.648 bits (727), Expect = 1.112e-87 Identity = 138/302 (45.70%), Postives = 202/302 (66.89%), Query Frame = 0
Query: 635 KDYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHG-EESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
K+++ L W D+ET ++AL K+ +++E IGY + ILN T +D LY LDL +F+N S KW + + ++ W + +VNAFY+PL+NSIN+PAGILQG F++ +RPNYLN+G+IG IGHE+THGFDD+G+QF+ EG+L +WW T +F K C +++Y +F P+LN T+ G + GE IADNGG+ AY AY++W+ + E +LPGL+ T KQLFW S AN WCT+ + ++ ++ VH A +RV FSN +FA+DF+CP+GSPMNP++KC++
Sbjct: 93 KEFEKLLRQNKWSDEETKAKALKKVKAMHENIGYPNEILNNTVIDILYEGLDLGESTYFENVHSLFKWTMDYVFLKIENEIKSYDWTDLVTPTVVNAFYNPLTNSINIPAGILQGNFFSLHRPNYLNFGAIGMAIGHEITHGFDDTGRQFNFEGDLFDWWNPSTKLKFINKTKCIIEEYGDFAYPKLNTTVNGVNTLGENIADNGGLKVAYRAYASWLNQTSFPEPLLPGLNFTEKQLFWISNANLWCTKIRGKTLEQKIRRDVHTPAMFRVLGAFSNMVKFAEDFQCPIGSPMNPKIKCEV 394 HSP 2 Score: 69.3218 bits (168), Expect = 1.696e-12 Identity = 29/103 (28.16%), Postives = 56/103 (54.37%), Query Frame = 0
Query: 389 MTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRLIQGK 491
M ++ TP +++IW I +S+ Y+N + R + ++ ++ +G ++ S RWK C+ T + + +G YV +FP +AK +V+ + + F L Q K
Sbjct: 1 MLIRKTPIRVQANFLIWSVISSSMSYLNEEARHIQFKYIQKLTGAKTMSERWKTCVGETKSRLGIHIGSMYVRQYFPEKAKTAAQSIVSYIKKEFEKLLRQNK 103
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000009482 (supercontig:LSalAtl2s:LSalAtl2s611:16796:20138:-1 gene:EMLSAG00000009482 transcript:EMLSAT00000009482 description:"maker-LSalAtl2s611-augustus-gene-0.6") HSP 1 Score: 290.041 bits (741), Expect = 2.772e-85 Identity = 143/316 (45.25%), Postives = 199/316 (62.97%), Query Frame = 0
Query: 636 DYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEG----------------NLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
++ + +DWMD +T + A K NSI + IGY +L+ ++ LY L L + +NAL+ + + +++ L + ++ W + AIVNAFYSPL NSI PAGILQG F++ +RP Y+NYG+IG++IGHE+THGFDD G+QFD EG NL +WW T E++ KA C ++QY N+ +PELN+T+ G + QGE IADNGGI AY AY WV+++ EE +LPGL+ + KQLFW SAAN WC + + +K V GVH +RV PFSN EFA+DF CP GS MNP +C++
Sbjct: 478 EFDKILNQIDWMDAKTKAMAKKKANSIVDHIGYPPELLDDNKLEELYDGLQLGNLHYLENALNMTVFVANYAFSLLREKVNKTDWVRHGKPAIVNAFYSPLENSIQFPAGILQGIFFSSDRPRYMNYGAIGWVIGHEITHGFDDQGRQFDLEGIFIFFKNIDNIPFFLGNLVDWWHPTTKEQYLKKAKCIIEQYGNYFLPELNITLNGINTQGENIADNGGIKEAYRAYVNWVDRNEEEKLLPGLNYSQKQLFWVSAANVWCAKFRPKALKLRVLTGVHSPDMFRVRGPFSNMPEFARDFNCPKGSHMNPAKRCEV 793 HSP 2 Score: 235.343 bits (599), Expect = 9.962e-66 Identity = 113/395 (28.61%), Postives = 209/395 (52.91%), Query Frame = 0
Query: 91 EICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWP--LGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
+ C + C+ A E+++NMD ++DPCEDFY +SC GF + +IPDDR+ +S S+L+D++ ++R + + R ++ + ACM+ +++E LG P+++ L GGWP +G G W + + L +G++ +YL V D KN++ I L QPR L+ + L +G+ ++ VQAYY + D+A G + K + ++++ E+ LAN + + + LYN MT+ +LT+ PF W+ Y+N + + + Q+ + ++V P Y + ++ + +T D +Y++WR + S+ Y+N + ++ QF ++ +G ++PRW+ C+ VG Y+ +F E++ EMV + F
Sbjct: 95 DYCMSKGCITTASEILRNMDESVDPCEDFYRFSCGGFIDKTIIPDDRTRMSSFSVLSDELLAQVRYLLESESLANEPRPFRMAKDVYNACMNKEQIEVLGQDPIKNILDRLGGWPVIIGDSW-NNGGKPYVWYKQVYMLRRIGYSVDYLVDFSVAIDLKNSSRRILDLDQPRFVLDREYLIKGFNDEDVQAYYEFMMDVARFFGANENRAAKD-MKEVLELEMKLANFSLPRENRRNATKLYNPMTIKDLTKLDPFTPWLDYINNILTKE--------IIQVNDKEVIIVNVPSYIKNFSLLINNTSDRVKANYLLWRVVSASIKYLNDDAKKISLQFSKKLTGKTEETPRWRTCVDGAKRSLTNAVGAMYIRKYFKEESRKSACEMVKDIRIEF 479
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000006703 (supercontig:LSalAtl2s:LSalAtl2s372:146954:340151:1 gene:EMLSAG00000006703 transcript:EMLSAT00000006703 description:"maker-LSalAtl2s372-augustus-gene-3.13") HSP 1 Score: 273.863 bits (699), Expect = 7.395e-80 Identity = 133/291 (45.70%), Postives = 181/291 (62.20%), Query Frame = 0
Query: 645 DWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
+WMD+ET A K NS+NE IGY + I N ++ Y +L + P F N + ++ ++ +L + +D W + A+VNAFY+P N I PAGILQ FY+++ P LNYG IG +IGHE+THGFDD G+QFD+ GNLK WW N+T EF A C +DQYS + + ++ L I G+ QGE IADNGG+ A+ AY+ WV +GEE +LPGL+LT KQLF+ + A WC E+ K ++ VH RV P SNS +FA+ + CP GS MNPE KC +
Sbjct: 455 EWMDEETRLVAKDKANSMNERIGYPEYITNKARLNQEYENLSITPVNFLDNLFNILRFEASNNQRKLRLAVDKDKWQT--EPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKFGNLKQWWNNRTIAEFHNAAQCIIDQYSTYMISDIQLNINGRMTQGENIADNGGLKQAFRAYNKWVRINGEEDLLPGLNLTHKQLFFLNYAQIWCGSMRPEDAKTKIRAAVHSPGPIRVLGPLSNSVDFAEAYSCPKGSRMNPEQKCSV 743 HSP 2 Score: 162.155 bits (409), Expect = 1.973e-41 Identity = 105/397 (26.45%), Postives = 191/397 (48.11%), Query Frame = 0
Query: 91 EICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTW-VQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGL---EYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
+IC T CV + L+ MD T DPC F+ Y+C + ++ +IP+DRSS+S ++ADQ+Q L+ + +E F+++CM+ ++E + PL + GGWP+ TS W ++ ++ FT VG D +N++ +I + Q GL +Y L+E ++ ++AY+ Y ++ LLG KT + +I+FE ++AN + D + ++Y ++L +L + P ++W Y + V + I N+++V YF+ L LK T I +Y+IWR + +P++ Q + ++F R G + RW C+ + + VG ++ +F ++K+ M+ + EAF
Sbjct: 68 KICLTQECVQTSAYLLGAMDTTADPCTXFFQYACGAWNRKHVIPEDRSSISTFEVMADQLQIILKGLLEEDHNEFDCEATLKVKNFYKSCMNISQIERISDTPLVQAINGLGGWPVVDPY----WTSHNWTIERVIGILKKNFTLGIFIEEWVGPDDRNSSAHIIQIDQMTFGLPSRDYFLLEES--DRDLKAYHIYMTEVGALLGANKTYAYEQ-FQNVIRFEKSIANISVPEHDRINTGAIYTKISLKDLKTEVPEINWNDYFDTV----------MGIGYIGDNEQIVSYSMPYFKLLGKLLKQTDKKIIHNYMIWRTVLELMPHLPPQYESTRAEFRRVLLGVLTGRIRWHKCVDWANKKMGMAVGALFIRDNFNYDSKEIALSMIHDIREAF 447
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000006546 (supercontig:LSalAtl2s:LSalAtl2s358:80738:83514:1 gene:EMLSAG00000006546 transcript:EMLSAT00000006546 description:"maker-LSalAtl2s358-snap-gene-0.19") HSP 1 Score: 218.009 bits (554), Expect = 7.834e-60 Identity = 111/291 (38.14%), Postives = 173/291 (59.45%), Query Frame = 0
Query: 646 WMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHG-EESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
WMD T +RA+ K +SI ++IGY D ILN ++ Y+ L++ +F+N L+ S++ +S +L + + W VNA+Y+P+ N I P+G+LQ F+ + P LN+G++G ++GHEL+H FDD G+++D+ GN+ +WW N T F+ K C QYS++T+ N +++G GE IADNGG+ +Y AY+ W+E++ E LPG+ L S+QLF+ WC+ S E + + H K+RV P SN +EFA F C S MNP+ +C+I
Sbjct: 513 WMDATTKARAVDKAHSITDMIGYPDYILNKNDLNKKYKGLNVSESDYFRNTLAHSQFVFVESLKKLFKKVNLTQWSM--TPPTVNAYYTPVKNQIVFPSGLLQNPFFALDYPKSLNFGAMGVVMGHELSHAFDDEGRKYDKNGNMVDWWLNSTTLNFKNKLTCMTQQYSHYTLH--NESVDGNITVGENIADNGGLKASYRAYTKWLEENTIPEVRLPGIKLNSRQLFFV-----WCSSSTKETDHFQLMEDHHSPGKFRVLGPLSNFKEFANVFLCSPYSKMNPKERCEI 794 HSP 2 Score: 139.428 bits (350), Expect = 5.133e-34 Identity = 121/480 (25.21%), Postives = 200/480 (41.67%), Query Frame = 0
Query: 42 GITL---QANLGWTDNVAGLVTISALLAVFVVNTVLDGAIEDELGIRLRGGPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDS-KEVENLGLQPLRDFLKIP-GGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLE----YKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTD---------LKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDT-----TIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRLIQGKSYAAAAK 498
G+TL + +G V G+ T+ L+ ++ + T R +C TP+C+ + ++ +MD +DPCEDFY ++C ++ IPD +SS S L + Q L+ I E + S + +F +C D ++E + +PLR + GW + M S Q L+ + F + D N++ ++ L Q L L Y + EG K + T +LL E D +K T+ + FE +AN T S + ++LYN MTLG+L Y F++W YVN+ ++ I ++ VVV P+YF+ LT + T T+ +Y+IW+AI+ ++ R + G RW+ C+T T +G +V F ++K M+ + EAF L + A K
Sbjct: 62 GVTLCFKKTKMGNKVFVGGVCTLVILVVIYFLTTKCS-----------RSNKSVCLTPDCIQISASILSSMDQDVDPCEDFYKFACGKWELSNPIPDGKSSWSPFEKLHEANQLVLKNILFEKNNTQISGAEEKARRYFYSCFDEGGKIEEVKGEPLRKIINNDMEGWIV---MDPSYNISNFDFQRKMYLLQNKYHFGGFFSWSIVEDESNSSQHVIQLDQGGLSLPTQDFYVKDTEGNKRVIKALEIMMTRLFRLLLQEEYPNDPITKEGEDNIKQTVLDITNFEKRIANITISTSQRKQENNLYNRMTLGQLNVNYNFMNWSIYVNEAFSQINKT--------IPEDEAVVVNAPKYFKALTDLINEHKATDNGKMTLNNYMIWQAIRDMKNTLSKSYRDTDLILQKAMFGKEGHEERWRSCITDTDAVIGYALGAMFVRKVFQGQSKTVAEGMINRIKEAFIANLNEAAWMDATTK 519
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000000064 (supercontig:LSalAtl2s:LSalAtl2s100:449072:453177:1 gene:EMLSAG00000000064 transcript:EMLSAT00000000064 description:"maker-LSalAtl2s100-snap-gene-4.23") HSP 1 Score: 214.927 bits (546), Expect = 1.520e-59 Identity = 116/300 (38.67%), Postives = 169/300 (56.33%), Query Frame = 0
Query: 637 YKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEE-SILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
YK+L +W+ +ET AL K +++ E I Y LN T ++ LY++L+L +F+N Q+ LPAG+LQG F++ +RPNYLN G++G+IIGHE+THGFD +G+Q+ ++G L+NWW+N+T F ++ CFV+QY N+++ +N T GK E IADNGGI AY A+ W + + +LPGL+ TS QLFW S AN WC+++ + + V H LA RV++ FSN FA DF CP SPMNP +C++
Sbjct: 409 YKILNNT-NWVGEETKRTALEKAHAMFEHIAYPSEYLNDTKLEELYQELNLENLTYFKNL-------------QI------------------------------LPAGVLQGLFFSADRPNYLNLGTMGWIIGHEITHGFDSNGRQYTKDGVLENWWDNQTVTNFLNRSQCFVEQYGNYSIKNVNQTNNGKRTLHENIADNGGIRAAYQAFIEWKNNNTKSIELLPGLNFTSNQLFWLSGANMWCSKNLKKVEESLVLTDEHSLATARVDLSFSNHEGFALDFSCPNDSPMNPPERCRV 664 HSP 2 Score: 193.741 bits (491), Expect = 3.200e-52 Identity = 108/394 (27.41%), Postives = 195/394 (49.49%), Query Frame = 0
Query: 93 CQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTK---KGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
C T C A+ ++ NM+ ++DPC+DFY ++C GF + + S ++ S + + ++ +L+ + + + + F+QAC++ +E +GL+PL++ + GGW L + ++ KGT W L + G++ N++ + D N + I + P G+ L +G + V+AY+ Y D AV LG TD++ L ++ FEI +AN T+S + ++ LYN M + LTQ P + W+QY+N + Q+Q E++V +P Y L + T ++ Y+ WR I++S+P +N + +++ F + SGT R C+ S+ VG YV + F +K+ + +MV V + F
Sbjct: 27 CVTEACNDTAKTILFNMNKSVDPCDDFYQFACGGFVNKTVFRPGESRLNTFSEIRNLLKNQLKTLLEMNPTSNDIKPFVMVRNFYQACINETAMEMVGLKPLQETILSLGGW-LDTEDKSDVSTKGTKYNWTSDLKILREYGYSTNFIMEFHIFQDLNNHSKRILLIDTPGFGIYRDFLVKGRGDFEVEAYFKYMKDAAVFLGH-NLTDVQENLQSILNFEIQMANLTKSIDERINITELYNRMQIKNLTQLNPCIPWIQYINS----------FLKITQVQKEDEIIVYEPAYISGLYRLMNKTSLKVVKDYVRWRFIESSLPELNKAAQNISNAFNDELSGTNGQKERDITCIEIVSDKLEHAVGAMYVRTFFKESSKENIKDMVESVRQVF 408
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000002013 (supercontig:LSalAtl2s:LSalAtl2s135:683680:686597:-1 gene:EMLSAG00000002013 transcript:EMLSAT00000002013 description:"maker-LSalAtl2s135-snap-gene-6.23") HSP 1 Score: 208.379 bits (529), Expect = 1.279e-57 Identity = 117/297 (39.39%), Postives = 168/297 (56.57%), Query Frame = 0
Query: 645 DWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKD---SWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESI--LPGLD-LTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
DWM T + AL K ++ +GY L+ + Y L+L+ +F N + + W D S LN+ ++ W ++A+VNA+YS NS+ PAG+LQG F++ +RP YLN G IG+IIGHE++HGFD+ G Q D++GNL NWW+N T + + K C QY N+TV +N+T++G++ E IADN GI +AY + W E +I LPG D T Q FW SAAN +C + ++ K + + YR+ FSN EF+ DF C GS MN KCK+
Sbjct: 322 DWMTNGTKASALEKALAMFNHVGYPAEYLDNDTLTERYNGLELNSLDYFGN---KHRIWTFDLDFSIKSLNKRVNKTSWIYNGESAVVNAYYSTDENSLIFPAGMLQGMFFSVDRPTYLNLGGIGWIIGHEISHGFDNVGSQIDKDGNLFNWWDNVTAQIYEEKIKCLKYQYGNYTVESVNVTVDGEYTLEENIADNMGIRNAYLTFLKWKTSQTERNIEYLPGFDNYTINQAFWLSAANDYCIKMTSKTEKQRAETLPYAPEIYRIIGSFSNQPEFSSDFNCLAGSKMNRTEKCKL 615 HSP 2 Score: 83.1889 bits (204), Expect = 1.308e-16 Identity = 36/112 (32.14%), Postives = 61/112 (54.46%), Query Frame = 0
Query: 93 CQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGW 204
C T C A++L+ N++ +++PCEDFY Y+C GF R +IP R + S L ++ +L+ + + F+++C++ ++E GLQPL+D L GGW
Sbjct: 26 CTTQACNDTAKKLLLNINPSINPCEDFYQYACGGFVNRTVIPPGRKGIDIASELTRKLNKQLKTVLEANSSSNEPGAFITARNFYKSCVNESQIEVQGLQPLKDILSKLGGW 137 HSP 3 Score: 79.337 bits (194), Expect = 2.287e-15 Identity = 50/218 (22.94%), Postives = 94/218 (43.12%), Query Frame = 0
Query: 299 LKSTLTKM------IQFEINLANATRSWADVSDVDS-----LYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRLIQGKSYAAAAKKGFLVKV 505
LK L+K+ E N++ W + ++++ LYN M++ L+ P + W+ Y+N + L Q+ + E++V +P Y L +K+T + +++ W+ ++ S+PY+N + + ++ + GT R C+ + VG YV S F +K+ V EM+ E F +I+ K L K
Sbjct: 127 LKDILSKLGGWLNSTHNESNISGIKYDWRNDANLEQKSIADLYNKMSIKNLSNLNPCVPWLDYIN--------IFLTKELIQVNGSDEIIVTEPYYVRNLYNVMKNTSLKVVNNFVRWKIVQNSIPYLNKEASIIREKYISKIYGTSGPIDRSLICVEEANKNLQNAVGAMYVRSFFKNGSKEDVEEMIGNTREVFYQMIIESDWMTNGTKASALEKA 336
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000009818 (supercontig:LSalAtl2s:LSalAtl2s639:492787:496659:1 gene:EMLSAG00000009818 transcript:EMLSAT00000009818 description:"maker-LSalAtl2s639-augustus-gene-5.12") HSP 1 Score: 179.874 bits (455), Expect = 2.069e-47 Identity = 101/293 (34.47%), Postives = 153/293 (52.22%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLD-LHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
+ WMD ET RA +K+ + LIGY +L+ M Y+ L L + F N LS + ++ L +++ W + AI N Y L N+ + AGI++G Y E+RP Y+N+ + +I GHE+TH FD G+ +E+G +NWW N T F K C ++QY+N+ +H +D+ + + SA +E +LPGL+ T +QL+W S+AN WC+ N E+I +N + H KYRV P SN EF+K F C +PMN KC++
Sbjct: 418 VSWMDDETKKRAEVKMRKMKILIGYPPELLSDVEMKKYYQGLQSLEKDKHFTNMLSLMHYSKTKDYSLLRVPVTKNHWTKSGTIAIGNGAYRSLVNAYEIYAGIIRGIIYAEDRPKYINFALLAFIAGHEITHAFDVHGRTINEKGEEENWWSNATLTMFEDKKQCLINQYNNY-----------EH------SDDTPLNGEFLLISAIKNDDHDEDLLPGLNYTQEQLYWISSANLWCSVYNPEHI-FNEIFDDHSPNKYRVIGPLSNRPEFSKAFHCAANTPMNRTEKCQM 692 HSP 2 Score: 155.221 bits (391), Expect = 2.489e-39 Identity = 103/381 (27.03%), Postives = 182/381 (47.77%), Query Frame = 0
Query: 91 EICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWP-LGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKD 470
++C + C A+ +++NMD T++PC+DFYA+SC GF + ++P+ V+ + D + ++ + +E L + K F++ C+D ++E LG+ P++D LK GGWP + +K + W KL +GF+ Y V TD KN I L QP +G L+ G N + Y Y +MA LLG + K L ++ +F+ +L N + +++D Y LM + +L + + W Y+N + + S+F + +EVVV Y E+L + TP +Y++WR ++ S+ Y+N + + +A+ F G ++ R K C + + Y+ + KD
Sbjct: 32 KVCNSIGCQQTAKTILENMDSTVNPCDDFYAFSCGGFINKTIVPNGEEKVNVLTKTKDGLIRDINDLMNEELNSSELQIFKDLKTFYKTCIDENKIEELGVTPMKDILKQMGGWPVIECDSWSKPRQTYRWYNETLKLRKLGFSAKYFLNFLVETDIKNPNKRIIMLDQPYVGFSKFLLQFG--NDGIIEYIQYMVNMAXLLGATEEKARKEML-QVFEFQKSLMNISIKDPNLTDQ---YELMKVKDLRKLDGCIDWQSYINGMISNS-------SIFVEKE-EEVVVYGRSYIEKLKNLILKTPIRVQANYMLWRVVEDSLLYLNKEAQDIANNFVTPVFGYAPETDRTKVCYKIVEESIGIGMSSMYIRRYLAKIPKD 398
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000004915 (supercontig:LSalAtl2s:LSalAtl2s2594:1939:5295:-1 gene:EMLSAG00000004915 transcript:EMLSAT00000004915 description:"maker-LSalAtl2s2594-snap-gene-0.3") HSP 1 Score: 171.785 bits (434), Expect = 3.869e-45 Identity = 112/326 (34.36%), Postives = 160/326 (49.08%), Query Frame = 0
Query: 637 YKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFD------EEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKH---------------------GEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
YK+L W+ +ET AL K ++I + Y L+ T ++ LY+ LDL + ++ W + IVNAFYS L+N++ LPA ILQG ++ +RPNYLN G+IG+IIGHE+TH D ++ + NL ++KT F F + + F +N TI+G+ GE IADNGGI AY AY W + G ILPGL+ TS QLFW S AN WCT+ T++ + +K H R++ FSN+ +F +DF P+ S MNP KC++
Sbjct: 328 YKILANA-TWLGEETKKNALDKAHAIFVHVAYPSEYLDDTKLEELYKGLDL-------------------------DAVNKTDWVNNGKGVIVNAFYSGLNNALVLPAAILQGLVFSADRPNYLNLGAIGWIIGHEITH--DQLTRKIKCIFLLWDRVNLSAISKSKTIIVFVFFHIYMLFKRHFFCYKSVNKTIDGELTLGENIADNGGIREAYQAYLEWKNNNTGSIEILPGLNFTIEWKNNNTGSIEILPGLNFTSNQLFWLSGANMWCTKIRTKSEEMLIKTNPHSFPIARLDFSFSNNEDFVRDFNRPVDSKMNPSKKCRV 625 HSP 2 Score: 144.436 bits (363), Expect = 4.462e-36 Identity = 93/380 (24.47%), Postives = 166/380 (43.68%), Query Frame = 0
Query: 109 MDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRT--KKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMV-ALVTEAFRI 485
M+ + DPC+DFY ++C GF + ++ D V+ S ++D+V L+ + E ++ + ++AC++ +E GL+PL+ + GGW + +KG W L + ++ N L L +AY+ Y D AVLLG T+++ L ++ FEI +AN T+S + D+ LYN M + LT P + W+ Y+N ++ Q+Q+ V+V +P Y + L + + ++ Y WR I++S+P +N+ + ++ F GT S C+ SN VG YV F +K + +M+ ++ E ++I
Sbjct: 1 MNNSADPCDDFYQFACGGFLNKTVVKSDEIKVNTFSEISDRVT--LKHYWKXXSTTEDTKPFVLVRNLYRACINETAIETAGLEPLQKMISKLGGWLDTKDIHDMLRKGKKYNWTTDLKLLRENXYSTNILLEL-------------------------------------KAYFQYMKDAAVLLGH-NLTEVEGKLQNILDFEIKMANLTKSKDEKKDISVLYNKMQIKNLTTLNPCIDWLDYINSFLKTT----------QVQNEDNVIVSEPSYVKNLYGLMFDSSLEVVKDYARWRVIESSIPNLNAAAQNISEAFSNNLYGTSSKQSIEITCIQLVSNKLKHAVGAMYVRDFFKESSKKNIKDMIHSIRLELYKI 330
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Match: EMLSAG00000000565 (supercontig:LSalAtl2s:LSalAtl2s1093:286030:293067:1 gene:EMLSAG00000000565 transcript:EMLSAT00000000565 description:"maker-LSalAtl2s1093-snap-gene-1.20") HSP 1 Score: 169.859 bits (429), Expect = 5.995e-44 Identity = 98/296 (33.11%), Postives = 150/296 (50.68%), Query Frame = 0
Query: 637 YKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLD-LHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELN--LTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLD-LTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMN 928
+K L WMDKET ++A K++S+ + +GY D + + ++ Y++LD L PK +N +++ AA ++ PAGILQ F+ + P IG +IGHE+THGFDD G Q+D GNL WW N + E F+ + +C ++QYS F VPE++ + G QGE D GG+ ++ AY WV + +E LP L+ TS+Q+F+ + + TWC +++ + H K+R P SNS+ F+K F C PMN
Sbjct: 474 FKELVAESSWMDKETQNKAKEKVDSMVQSLGYPDWLKTESEIEKKYKELDELKPKTLLENI------------------------KKYNNAA-----------AVTFPAGILQYPFFESSNP------IIGVVIGHEITHGFDDQGSQYDNNGNLVKWWSNSSLEAFQKEKECIIEQYSAFNVPEISEETYVNGVLTQGENXXDXGGLRESFRAYKKWVNSNNDEPKLPELEKYTSEQMFFIAYSQTWCQVKTKASLQNQILSDPHSPGKFRSWGPVSNSKSFSKAFNCKPSDPMN 728 HSP 2 Score: 122.865 bits (307), Expect = 6.357e-29 Identity = 94/412 (22.82%), Postives = 183/412 (44.42%), Query Frame = 0
Query: 91 EICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQ---YELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGL---------EYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFP------LLVGKFYVESHFPPEAKDKVSEMVALVTEAFR 484
E C T C +A+ +I MD+ + PCEDFY ++C + K PD +S S + L++ + E+ + D+ +P E + A+ +++++C++ + + G + + G P + ++ +LA + + L V D +NT +I ++ Q LGL +YKE+ + + + +Q+ T + + +P L L M QFE +A + ++YN M+L ++ + Y + W Y N++ + + I+ N +++V +P YFE+L L T D I +YI WR + ++P ++R F + G + + R C + F V Y++ F ++K++V +MV + +F+
Sbjct: 79 EXCTTEVCKTSAKSIISKMDVNVSPCEDFYEFTCGKYVKDNTNPDGQSDXSIFADLSNDIMTTTLEILEANDDDVP-EVVKKAR---SYYKSCINMSSINDEGKKQYKTIFGSKGALGGYPILNSQWNLEEKSKELALGRVLYDYNEGILIQSYVYLDAQNTAQHILYMDQASLGLLRINFVDSEKYKEIIKAY--RTLQSSTAETLFKYLDINKPDDDKLNEDLESMFQFEKAIAGIMVPEDQRRNSTAMYNPMSLAKIMKSYTQIKWKIYFNELLKGDN---------AIEENDKIIVAEPYYFEKLNELLNETDDKIIYNYIHWRILLQTLPNGPDEMREHYKTFLKDAMGIKKEVLRDNICAKRVAAPFDGMGGLGFAVAYEYIQKKFDDDSKNEVKKMVGGLKSSFK 475
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|1270743871|sp|A0A0B4K692.1|NEP2_DROME (RecName: Full=Neprilysin-2; Contains: RecName: Full=Neprilysin-2, soluble form) HSP 1 Score: 299.671 bits (766), Expect = 1.403e-87 Identity = 136/292 (46.58%), Postives = 191/292 (65.41%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
++WMD +T A +KL+S+ IGY D +L+ + Y LD+ P ++F++ L + + S+N+L ++ W + AIVNAFYS L NSI PAGILQG F+N RP Y+N+G+IGY+IGHE+THGFDD G+QFD +GNL++WW T + + KA C ++QY N+T L + G + QGE IADNGG+ +Y AY W EKHG E+ LPGLD T +Q+FW +A TWC + E++K + GVH +++RV SN ++FAKDF CP GSPMNP KC++
Sbjct: 482 VNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEV 773 HSP 2 Score: 205.297 bits (521), Expect = 3.912e-54 Identity = 122/406 (30.05%), Postives = 198/406 (48.77%), Query Frame = 0
Query: 91 EICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDL-KSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLD-PEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCL-TATSNF----------FPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
++C T C+ A +++ M ++PC++FY ++C + + IPDD+ S+S S+++D++Q +L+ I P + ++P ++ACM+ +E LG +P+ + GGWPL S TW + K GF+ +Y+ +G D +N+T + L Q L L + L +G+ +V AYY Y D+AVL G + DL K+ L ++FE+ LAN + + LYNL T +L YP++ WV Y+N + VA+ E++ L P +FE L L TP I +Y+ WR SV +++ + R Q+ SG + RWK C+ ATS+ + VG YV HF ++K EMV + F
Sbjct: 82 DVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANR--DLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAE----------DEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVF 475
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|74949025|sp|Q9W436.2|NEP_DROME (RecName: Full=Neprilysin-1) HSP 1 Score: 278.485 bits (711), Expect = 3.683e-79 Identity = 132/291 (45.36%), Postives = 179/291 (61.51%), Query Frame = 0
Query: 645 DWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
DWMD ET + A K +S+NE IGY +++ N T ++ Y +L + P F N LS +W + L Q ++ W + A+VNAFY+P N I PAGILQ FY+++ P LNYG IG +IGHE+THGFDD G+QFD+EGN+ WW N T E FR + C +DQYS + + E+++ ++G+ QGE IADNGG+ A+ AY W HG E LPGL++T QLF+ + A WC E+ ++ VH RV P SNSR+FA +KCPLGS MNP KC +
Sbjct: 560 DWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWT--TEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSV 848 HSP 2 Score: 181.415 bits (459), Expect = 6.564e-46 Identity = 116/412 (28.16%), Postives = 196/412 (47.57%), Query Frame = 0
Query: 75 DGAIEDELGIRLRGGPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLG-EPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
+G + G G IC T CV A L+ MDL DPCEDF+ Y+C + K IP+DRSS+S +L+DQ Q LR + +E + ++ FF++CMD ++ +G L+ L+ GGWP+ R + V+ + + ++ + L VG D KN++ NI + Q + L ++ LKE N +AY+ Y +A+LLG +P T + L K++ FE L N + AD D +Y M L EL + P + W +Y+ A + +Q ++ +V Y + L T + +Y++WR + + + +M + + +F + G +S+ RW C+ T+ + VG ++ +F E+K+ EM+ + AF
Sbjct: 155 NGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPV--IERNWSPPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDR-RAYHRYMTQVALLLGADPATA--AAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQ---------AALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAF 552
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|74930356|sp|Q8IS64.1|ECE_LOCMI (RecName: Full=Endothelin-converting enzyme homolog; Short=ECE) HSP 1 Score: 268.47 bits (685), Expect = 1.455e-76 Identity = 130/292 (44.52%), Postives = 184/292 (63.01%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
L WMD ET A K ++I+++IG+ D ILN +D Y+DL++ ++F+N L +K+ LK + +L+Q ++ W VNA+Y+P N I PAGILQ FY+ P +NYG++G ++GHELTH FDD G+++D+ GNL WW N+T E F+ + C VDQYSN+TV N + GK GE IADNGG+ AY AY W +++ E LPGL+ + KQLF+ S A WC+ S E IK ++ H K+RV P SN +EF+ +F+CPLGS MNP KC++
Sbjct: 439 LKWMDAETRRAAEKKADAISDMIGFPDYILNPEELDKKYKDLEIKEDEYFENNLRVNKYNLKSNLEKLDQPVNKTRWGM--TPPTVNAYYTPTKNQIVFPAGILQAPFYDIGHPKSMNYGAMGVVMGHELTHAFDDQGREYDQNGNLHKWWNNQTIEAFKKRTQCVVDQYSNYTVD--NKHVNGKQTLGENIADNGGLKAAYHAYLEWEQRNPRELPLPGLNFSHKQLFFLSFAQVWCSASTDEAIKLQLEKDPHAPPKFRVIGPLSNLQEFSTEFRCPLGSKMNPVHKCEV 726 HSP 2 Score: 162.54 bits (410), Expect = 3.504e-40 Identity = 111/450 (24.67%), Postives = 206/450 (45.78%), Query Frame = 0
Query: 64 LLAVFVVNTVLDGAIEDELGIRLRGGPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKE-VENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTT-----IQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFR-----IRLIQGKSYAAAAKKG 500
LLA+ +V+ VL L C + +CV AA ++ MD T DPC DFY Y+C G+ + IPD +S L Q Q ++ + ++ + S + ++ +C+D + +E LG +P+ D L GGW + K + ++ ++G LF VG D +++ +I + Q L L ++ L E +K++ AY Y + VLLG + ++++ + +I+FE LA D D + LYN M L ++ + PF++W + + + + +I ++VVV PEY E+L +++ +TT + +Y++W+ +++ Y++ R + G+ W+ C+T T+N +G +V F +K M+ + AF+ ++ + ++ AA KK
Sbjct: 20 LLALLIVSAVL--LSRPYAPALLHAEEAYCVSMSCVTAAASVLSLMDATADPCSDFYQYACGGWVRANPIPDTKSMWGTFVKLEQQNQLVIKNVLEQPMSEFKSEAERKAKLYYMSCLDVNDTIETLGPKPMLDLLVKIGGWNITGNFSIKNWSLQKSLETLQNRYNMGG----LFTWAVGEDDRDSKKHIIQIDQGGLTLPTRDNYLNETMDDKVLSAYLEYMTKIGVLLG-GEEKNVRTQMKAVIEFETELAKIMSPQEDRRDEEKLYNNMELDKVQGRPPFINWHAFFSNAMENITR--------KISKKEKVVVYAPEYLEKLNDIIRNYTNTTDGKIILNNYLVWQTVRSMTSYLSKAFRDAYKGLRKALVGSEGGEKPWRYCVTDTNNVIGFAIGAMFVREAFHGNSKPAAENMINQIRTAFKSNLKNLKWMDAETRRAAEKKA 454
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|1706564|sp|P42893.2|ECE1_RAT (RecName: Full=Endothelin-converting enzyme 1; Short=ECE-1) HSP 1 Score: 261.922 bits (668), Expect = 6.792e-74 Identity = 124/292 (42.47%), Postives = 183/292 (62.67%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
L WMD++T A K ++I +IGY + I++ +D ++ D P +F+NA+ + L+ + +QL ++ + D W +VNA+YSP N I PAGILQ FY + PN LN+G IG ++GHELTH FDD G+++D++GNL+ WW+N + E F+ + +C V QY+N++V + G+H GE IADNGG+ AY AY WV+K+G E ILP L LTS QLF+ A WC+ E+ + H +++RV SNS+EF++ F+CPLGSPMNP KC++
Sbjct: 474 LKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSM--TPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEV 761 HSP 2 Score: 173.711 bits (439), Expect = 1.067e-43 Identity = 111/434 (25.58%), Postives = 207/434 (47.70%), Query Frame = 0
Query: 58 LVTISALLAVFVVNTVLDGAIEDELGIRLRG-GPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDS-PRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRL 487
LV + LLA +V A LGI+ R P +C T CV ++ +MD T+DPC+DF++Y+C G+ K +PD S S L + Q ++ + + + +S K +++ACM+ +E L +PL + ++ GGW + T V AH + + F + V D KN+ +N+ + Q LGL ++ L + K++ Y NY + LLG ++ + +++ FE LAN T D + +Y+ +T EL P ++W+ ++N + + +I ++ +VV D EY +++ + ST + +Y++W ++ + +++ + + +F GT+ PRWK C++ T N +G +V++ F ++K+ SE++ + +AF L
Sbjct: 61 LVVLVTLLAAGLV------ACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAH------YRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAI----------FYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESL 471
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|81918086|sp|Q4PZA2.1|ECE1_MOUSE (RecName: Full=Endothelin-converting enzyme 1; Short=ECE-1) HSP 1 Score: 256.914 bits (655), Expect = 4.980e-72 Identity = 123/292 (42.12%), Postives = 180/292 (61.64%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
L WMD+ET A K ++I +IGY + I++ +D ++ D P +F+NA+ + + + +QL ++ + D W +VNA+YSP N I PAGILQ FY + PN LN+G IG ++GHELTH FDD G+++D++GNL+ WW+N + E F+ + +C V QYSN++V + G+H GE IADNGG+ AY AY WV+K+G E LP L LTS QLF+ A WC+ E+ + H +++RV SNS+EF++ F+CP GSPMNP KC++
Sbjct: 481 LKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSM--TPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEV 768 HSP 2 Score: 169.474 bits (428), Expect = 3.035e-42 Identity = 110/436 (25.23%), Postives = 209/436 (47.94%), Query Frame = 0
Query: 58 LVTISALLAVFVVNTVLDGAIEDELGIRLRG-GPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLP--LESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDS-PRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRL 487
LV + LLA +V A LGI+ + P +C T CV ++ +MD T+DPC+DF++Y+C G+ K +PD S S L + Q ++ + + E+ R A++ +++ACM+ +E L +PL + ++ GGW + T V AH + + F + V D KN+ +N+ + Q LGL ++ L + K++ Y NY + LLG ++ + +++ FE LAN T D + +Y+ +T EL P ++W+ ++N + + +I ++ +VV D EY +++ + +T + +Y++W ++ + +++ + + +F GT+ PRWK C++ T N +G +V++ F ++K+ SE++ + +AF L
Sbjct: 68 LVVLVTLLAAGLV------ACLAALGIQYQTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERKAQV---YYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAH------YRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTI----------FYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIIMEIKKAFEESL 478
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|1706563|sp|P42892.2|ECE1_HUMAN (RecName: Full=Endothelin-converting enzyme 1; Short=ECE-1) HSP 1 Score: 252.677 bits (644), Expect = 1.524e-70 Identity = 121/292 (41.44%), Postives = 180/292 (61.64%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
L WMD+ET A K ++I +IGY + I++ +D ++ D P +F+NA+ + + + +QL ++ + D W +VNA+YSP N I PAGILQ FY + P LN+G IG ++GHELTH FDD G+++D++GNL+ WW+N + E F+ + +C V+QYSN++V + G+H GE IADNGG+ AY AY WV+K+G E LP L LT+ QLF+ A WC+ E+ + H +++RV SNS+EF++ F+CP GSPMNP KC++
Sbjct: 482 LKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSM--TPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEV 769 HSP 2 Score: 168.703 bits (426), Expect = 5.059e-42 Identity = 103/412 (25.00%), Postives = 200/412 (48.54%), Query Frame = 0
Query: 82 LGIRLRG-GPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLP--LESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDS-PRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRL 487
LGI+ + P +C + CV ++ +MD T+DPC DF++Y+C G+ K +PD S S L + Q ++ + + + E+ R A++ +++ACM+ +E L +PL + ++ GGW + T V AH + + F + V D KN+ +N+ + Q LGL ++ L + K++ Y NY + LLG ++ + +++ FE LAN T D + +Y+ +T EL P ++W+ ++N + + +I ++ +VV D EY E+++ + +T + +Y+IW ++ + +++ + + +F GT+ PRWK C++ T N +G +V++ F ++K +E++ + +AF L
Sbjct: 87 LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV---YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAH------YRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTI----------FYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESL 479
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|74933939|sp|Q8T062.1|NEP4_DROME (RecName: Full=Neprilysin-4) HSP 1 Score: 256.529 bits (654), Expect = 2.109e-70 Identity = 123/308 (39.94%), Postives = 184/308 (59.74%), Query Frame = 0
Query: 631 HPHSKDYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEE---SILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
H + ++ + DW+D T A K+N+++ IGY D ILN + ++ Y ++++P+++F+N L+ K +L++ ++ W AIVNA+YS N I PAGILQ FY+ + P LN+G IG +IGHELTHGFDD G+ FD GN+ WW + + F +A C + QYSN+TV E+ + + G+ QGE IADNGG+ A+ AY W+++H E ILPGL++T QLF+ + WC E I+ + +H ++RV SNS +FA++F CPLGSPMNP+ KC +
Sbjct: 734 HDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQ--TAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSV 1039 HSP 2 Score: 114.005 bits (284), Expect = 2.009e-24 Identity = 79/310 (25.48%), Postives = 135/310 (43.55%), Query Frame = 0
Query: 176 FFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE-LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFR 484
+++C++S + GL+PL ++ GGWP+ ++ ++ W LA L + + L VG D KN+ NI Q LGL +E + K +QAY Y ++ +G K D + ++++ FE LA T +V LY MTL +L P + W Y+ Q ++ +EVV+ EY +L L T T+ +Y++WR ++ + ++ + + FY G RWK C+ + + VG +V +F +K M + +AFR
Sbjct: 448 LYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSE--SNFNWQVLAATLRR--YNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKA-DAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYL-----------QSLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFR 741
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|190359620|sp|P42891.2|ECE1_BOVIN (RecName: Full=Endothelin-converting enzyme 1; Short=ECE-1) HSP 1 Score: 251.521 bits (641), Expect = 3.263e-70 Identity = 121/292 (41.44%), Postives = 179/292 (61.30%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
L WMD++T A K ++I +IGY + I++ +D ++ D P +F+NA+ + + + +QL ++ + D W +VNA+YSP N I PAGILQ FY + PN LN+G IG ++GHELTH FDD G+++D++GNL+ WW+N + E F+ + C V+QY N++V + G+H GE IADNGG+ AY AY WV+K+G E LP L LT+ QLF+ S A WC+ E+ + H +++RV SNS+EF++ F CP GSPMNP KC++
Sbjct: 466 LKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSM--TPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTACMVEQYGNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTNNQLFFLSFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSISNSKEFSEHFHCPPGSPMNPHHKCEV 753 HSP 2 Score: 166.777 bits (421), Expect = 2.009e-41 Identity = 98/403 (24.32%), Postives = 195/403 (48.39%), Query Frame = 0
Query: 90 PEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLP--LESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDS-PRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRL 487
P +C + C+ ++ +MD T+DPC+DF+ Y+C G+ K +PD S S L + Q ++ + + + E+ R A++ +++ACM+ +E L +PL + ++ GGW + T V +H + + F + V D KN+ +N+ + Q LGL ++ L + K++ Y NY + LLG ++ + +++ FE LAN T D + +Y+ +T EL P ++W+ ++N + + +I ++ +V+ D EY +++ + ST + +Y+IW ++ + +++ + + +F GT+ PRWK C++ T N +G +V++ F ++K+ SE++ + +AF L
Sbjct: 80 PSVCLSEACISVTSSILSSMDPTVDPCQDFFTYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV---YYRACMNETRIEELKAKPLMELIEKLGGWNITGPWDKDNFQDTLQVVTSH------YHTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGAEDTIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTI----------FYPVEINESEPIVIYDKEYLSKVSTLINSTDKCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENTLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESL 463
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|1352911972|sp|P0DPD6.1|ECE2_HUMAN (RecName: Full=Endothelin-converting enzyme 2; Short=ECE-2) HSP 1 Score: 250.366 bits (638), Expect = 1.886e-69 Identity = 125/294 (42.52%), Postives = 172/294 (58.50%), Query Frame = 0
Query: 642 GMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
G L WMD++T A K ++I ++IG+ D IL +D +Y ++ FFQN L+ + K +QL + S D W Q VNA+Y P N I PAGILQ FY N P LN+G IG ++GHELTH FDD G+++D+EGNL+ WW+N++ FR C +QY+ + V L G+ GE IADNGG+ AY+AY AW+ KHGEE LP + LT+ QLF+ A WC+ E+ + H A++RV SNSR+F + F CP+GSPMNP C++
Sbjct: 521 GQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQT--VNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLN--GRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEV 810 HSP 2 Score: 162.925 bits (411), Expect = 5.375e-40 Identity = 103/407 (25.31%), Postives = 201/407 (49.39%), Query Frame = 0
Query: 93 CQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPL-GPKMRTKKGTSTTWVQLAHKLMDV--GFTGNY----LFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGT-RSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRLIQ 489
C T C+ A ++++++D + PCEDFY +SC G+ +R +PD RS + + L DQ Q L+ + + T SS + F+ +C+ + +E LG QPLRD ++ GGW + GP W Q M+V G Y F + + D K++ +N+ + Q L L ++ L K++ AY +Y ++ +LLG + T + + ++++ EI LAN T D + +Y+ M++ EL P + W+++ ++ + S ++ ++ VVV +Y ++++ + T + + +Y+IW ++ + ++ + + + GT +S PRW+ C++ T + +G +V++ F ++K+ M++ + AF L Q
Sbjct: 140 CLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGP-----------WDQ--DNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLG-GRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEF----------LSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ 522
BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Match: gi|2499916|sp|P97739.1|ECE1_CAVPO (RecName: Full=Endothelin-converting enzyme 1; Short=ECE-1) HSP 1 Score: 248.054 bits (632), Expect = 4.303e-69 Identity = 119/292 (40.75%), Postives = 178/292 (60.96%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
L WMD++T A K ++I +IGY + I++ +D ++ D P +F+NA+ + + + QL ++ + D W +VNA+YSP N I PAGIL FY + P LN+G IG ++GHELTH FDD G+++D++GNL+ WW+N + E F+ + +C V+QYSN++V + G+H GE IADNGG+ AY AY WV+K+G E LP L LT+ QLF+ A WC+ E+ + H +++RV SNS+EF++ F+CP GSPMNP KC++
Sbjct: 466 LKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTAEQLRKAPNRDQWSM--TPPMVNAYYSPTKNEIVFPAGILPAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVEQYSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEETLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFQCPPGSPMNPRHKCEV 753 HSP 2 Score: 174.481 bits (441), Expect = 5.757e-44 Identity = 111/436 (25.46%), Postives = 212/436 (48.62%), Query Frame = 0
Query: 58 LVTISALLAVFVVNTVLDGAIEDELGIRLRG-GPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLP--LESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKE--LKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDS-PRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRL 487
L+ + ALLA +V A LGI+ R P +C + CV ++ +M+ T+DPC+DF++Y+C G+ K +PD S S L + Q ++ + + + E+ R A++ +++ACM+ +E L +PL + ++ GGW + T V AH + + F + V D KN+ N+ + Q LGL ++ L + K++ Y NY + LLG +++ + +++ FE LAN T D + +Y+ +T EL P ++W+ ++N + + +I ++ +VV D EY E+++ + +T + +Y+IW ++ + +++ + + +F GT+ PRWK C++ T N +G +V++ F ++K+ SE++ + +AF L
Sbjct: 53 LIVLVALLAAGLV------ACLTALGIQYRTRTPPVCLSEACVSVTSSILNSMNPTVDPCQDFFSYACGGWIKANPVPDGHSRWGAFSNLWEHNQAIIKHLLENSTASVSEAERKAQV---YYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAH------YRTSPFFSVYVSADSKNSNRNVIHVDQSGLGLPSRDYYLNKTENEKVLNGYLNYMVQLGKLLGGGDENAIRAQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTI----------FYPVEINESEPIVVYDKEYLEQVSTLINTTDKCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFGLGPMFVKATFAEDSKNIASEIILEIKKAFEESL 463
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|1279738572|ref|XP_022914108.1| (neprilysin-2 isoform X1 [Onthophagus taurus]) HSP 1 Score: 314.694 bits (805), Expect = 1.505e-90 Identity = 142/293 (48.46%), Postives = 205/293 (69.97%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEK-HGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
+DWMD+++ RAL K +++ I Y D +L+ ++ Y+DL+L +++ + ++ +++ + S+N+L Q ++ W + AIVNAFYS + NSI PAGILQG F++ +RP Y+NYG+IG++IGHE+THGFDD G+QFD++GNL +WWE +T + F KA C +DQYSNFTVPEL + ++G + QGE IADNGGI AY AY AW+++ + E LPGL+ T KQ+FW SAA TWC++ E +K V +H + RV P N +EF++DF CPLGSPMNPELKC +
Sbjct: 481 VDWMDEKSRKRALEKAQAMSTHIAYPDELLDDKILEKFYQDLELDSEKYLMSVINLTQFATRFSFNRLRQPVNKTDWITHGRPAIVNAFYSAIENSIQFPAGILQGVFFSNDRPKYMNYGAIGFVIGHEITHGFDDQGRQFDKDGNLVDWWEPETQQSFVKKAQCIIDQYSNFTVPELGINLKGVNTQGENIADNGGIKEAYYAYEAWMKRTNTTEPQLPGLNYTPKQMFWLSAAATWCSKYRKEALKVRVLTSLHSPGRQRVIGPLRNLKEFSRDFNCPLGSPMNPELKCTV 773 HSP 2 Score: 232.261 bits (591), Expect = 6.388e-61 Identity = 124/395 (31.39%), Postives = 212/395 (53.67%), Query Frame = 0
Query: 91 EICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPL--GPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
++C TP C+ A ++++ +D ++DPC+DFY ++C F K+ IPDD+SSV+ S+++D +Q +LR + +E + + + + ++ACM+ +E GL+ ++ + GGWP+ G K K W Q +K G++ +YL V D KN+T + L Q LGL + L +G ++K+V+AYY+Y D+AV+ G KT K L + + FEI LAN + + +LYN MT+ EL KYP ++W +Y N + ++V N+ V+V P+Y + +K+T T +Y++WRA+ +SV Y+N ++R Q++ +G + RWK C+ + G YV +F +A+ +MV + F
Sbjct: 93 KVCLTPGCIHTASKVLETIDESVDPCDDFYDFACGNFVKKTNIPDDKSSVTTFSVISDLLQEQLRTMIEEPIRKDEPKPFVLTKKLYRACMNKTLIEKDGLKTIKGIVNELGGWPVLEGDKF---KDQEFDWRQTIYKFRKSGYSVDYLIDFSVAIDLKNSTKRVIDLDQASLGLRREFLIKGVEDKLVKAYYDYMVDIAVIFGANKTNAEKE-LKESLDFEIKLANISLPNEKRRNASALYNPMTVSELQSKYPIVNWKEYFNVLLAPDTKV---------DDNEVVIVSIPKYLKDFDDLIKNTSKRTQANYLLWRAVASSVSYLNDELRNRQLQYHTIATGKTERASRWKECIEIAAGSLGNAAGALYVRKYFNEDARQNAIKMVKDIRTEF 474
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|1253756085|ref|XP_022662069.1| (membrane metallo-endopeptidase-like 1 isoform X4 [Varroa destructor] >gi|1253756087|ref|XP_022662070.1| membrane metallo-endopeptidase-like 1 isoform X4 [Varroa destructor] >gi|1268032007|ref|XP_022689228.1| membrane metallo-endopeptidase-like 1 isoform X4 [Varroa jacobsoni]) HSP 1 Score: 313.538 bits (802), Expect = 1.963e-90 Identity = 151/332 (45.48%), Postives = 213/332 (64.16%), Query Frame = 0
Query: 618 GLSGWISDLHVRP--HPHSKDYKL------------LTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
GLS +S+L+V+ H SKD+ L + +DWMD T RA K +I IGY ++N T + Y ++ + ++F+N + +W S+ QL + + W + Q A+VNAFY+ L N I PAGILQG F++++RPNYLN+G+IG++IGHE+THGFDD G+QFD++GN KNWWE++T+E+F+ +A C + QY N+TVPE+N+ + G + QGE IADNGGI A+ AY WV+ +G E LPGL+ T+ QLFW SAAN WC + E ++ G H A YRV P SN+ EFA+ F CP+GSPMNP+ KC +
Sbjct: 419 GLS--LSNLYVKNFFHEDSKDHALSMVKYITNEFLNIIKEVDWMDSATRLRAKNKAEAIVPYIGYPSELMNDTLLSDHYTNVSMKSDEYFKNVMQLRRWSTDYSFGQLRKPHIKGEWKKHAQVAVVNAFYNSLENCIEFPAGILQGAFFSKDRPNYLNFGAIGFVIGHEITHGFDDRGRQFDKDGNNKNWWEHETDEKFKGRAQCIIHQYGNYTVPEINMPVNGINTQGENIADNGGIKEAFRAYRQWVKDNGPEGSLPGLNYTADQLFWISAANVWCGKYRPEVMRLRTISGSHSPAPYRVIGPMSNTIEFAEQFNCPIGSPMNPKHKCTV 748 HSP 2 Score: 200.675 bits (509), Expect = 3.815e-50 Identity = 112/394 (28.43%), Postives = 202/394 (51.27%), Query Frame = 0
Query: 92 ICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLA-FFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGL-EYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
+C T CV AA ++I+NMD T +PC DFY ++C + +R IPDD+SS+++ S++ D++ +LR I ++ + + + + L +Q+C+++ ++ LG +PL L+ GGWP+ K +S W+Q +G++ + +F L V DF+N T ++ L Q LGL + L +G + +V+AY+ + A LLG T + L + FE LAN + + ++ +LYN M L EL + P ++W Y N + + I ++ + V P + ++ L++ T+ +Y++WR + S + R F +G ++PRW+ C+T+ + L + YV++ F ++KD MV +T F
Sbjct: 68 LCLTQGCVKAAAQIIENMDPTTNPCSDFYQFACGQWIQRQSIPDDKSSITQFSIIQDELDAKLRVIVEKPVNPKKDQPHVVNLKNLYQSCVNTSTLDRLGEEPLLKVLRELGGWPVVEGANWKGNSSFNWLQTIIAFRKLGYSHDIIFDLSVIPDFRNNTKHLIDLDQATLGLPDRTYLLKGMSDSVVKAYFKLMTEAASLLGAKNTDQTRKELEDALHFETMLANYSLPREERRNISALYNKMPLSELKKFSPTINWDLYFNSL-----------LVDHIDDDEMINVGVPNFIAQVAKLLQTVDKRTLANYMMWRVVLQSYATLGKAWRDQLHNFNSVLTGKTRENPRWEQCMTSLTGSLGLSLSNLYVKNFFHEDSKDHALSMVKYITNEF 450
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|644996760|ref|XP_008208161.1| (PREDICTED: neprilysin-11-like isoform X3 [Nasonia vitripennis]) HSP 1 Score: 314.309 bits (804), Expect = 2.069e-90 Identity = 140/300 (46.67%), Postives = 203/300 (67.67%), Query Frame = 0
Query: 636 DYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
++K + +DWMD ET AL K +S++ I Y D +L+ T ++ Y L++ P + ++ L+ + + + S+ +L + ++ W + AIVNAFYS + NSI PAGILQG F++ +RP Y+NYG+IG+++GHE+THGFDD G+QFD+ GNL WW +T E++ +A C ++QY N+T PE++L + G + QGE IADNGGI AY AY+ WV ++G E LPGLD + +Q+FW SAANTWC++ E +K + GVH ++RV P SN EFAKDFKCP+GS MNPE KC +
Sbjct: 475 EFKKILDQVDWMDDETRKAALDKADSMSTHIAYPDELLDDTKLEQFYEKLEITPGNYLESILNLTLFGTQYSFEKLRKPVNKSDWVTHGRPAIVNAFYSSIENSIQFPAGILQGAFFSNDRPKYMNYGAIGFVMGHEITHGFDDQGRQFDKNGNLVEWWAAETKEKYLKRAQCIINQYGNYTAPEVSLNLNGINTQGENIADNGGIKEAYLAYNEWVRRNGAEPRLPGLDYSGQQMFWISAANTWCSKYRPETLKLRITTGVHSPGEFRVLGPLSNMDEFAKDFKCPVGSRMNPEKKCAV 774 HSP 2 Score: 247.669 bits (631), Expect = 2.999e-66 Identity = 155/495 (31.31%), Postives = 246/495 (49.70%), Query Frame = 0
Query: 5 NTLKTSVMMIPPKGKMDPALLKIGDSSILPCSTMKLLGITLQANLGWTDNVAGLVTISALLAVFVVNTVLDGAIEDELGIRL--------RGGPE--ICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRLIQ 489
N++K +V+ P K AL + G + I CS L+ I L LG A S+L++ +L E +G L PE IC +P C+ A +++NMD ++PC+DFY ++C F K +IPDD++SV+ S+++D++Q +LR +E R ++ ++ CM+ +E GL PL LK GGWP+ + G W + +K G++ +Y +G D KN+T + L Q LGL + L +G +K+V AYYNY D+A +LG + K L + ++FEI LAN + + +LYN MT+ +LTQK+P + W++Y + + + S + ++ V+V P + L L+ TP +Y++WRA TSV Y+N ++R + SG PRWK C+ S F + VG YV +F +AK EMV+ + F+ L Q
Sbjct: 3 NSMKQTVIKNPTWWKRRSALER-GLTIIAVCSV--LVAIALAIGLGVLARNAEPCE-SSLMSAPANAEMLPSTAEALIGAPLAKKVPQVVEKSPEGDICLSPGCIHTASSILENMDQNVEPCDDFYRFACGSFLKNTIIPDDKTSVNTFSIISDKLQKQLRSSIEEESKPNDPRPFRLLKTLYKTCMNKTLIEEEGLNPLHKILKELGGWPVLVGDKWSDG-DFNWKESVYKFGKKGYSVDYFIDFSIGVDLKNSTKRVIDLDQASLGLSREYLSKGMDDKIVSAYYNYMVDIAEILGADR-EQAKIELKESLEFEIKLANISLPSEKRRNATALYNPMTVRQLTQKFPTIPWLEYFSTL---------LPSSITVTEDEMVIVNVPSFITDLEKLLEQTPKRIQANYVMWRAAATSVSYLNDEIRKRQLAYSTVISGRTEREPRWKECVDIVSGSFSISVGALYVRKYFNEDAKKNAVEMVSNIRGEFKKILDQ 482
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|345492449|ref|XP_001600059.2| (PREDICTED: neprilysin-11-like isoform X4 [Nasonia vitripennis]) HSP 1 Score: 313.923 bits (803), Expect = 2.499e-90 Identity = 140/300 (46.67%), Postives = 203/300 (67.67%), Query Frame = 0
Query: 636 DYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
++K + +DWMD ET AL K +S++ I Y D +L+ T ++ Y L++ P + ++ L+ + + + S+ +L + ++ W + AIVNAFYS + NSI PAGILQG F++ +RP Y+NYG+IG+++GHE+THGFDD G+QFD+ GNL WW +T E++ +A C ++QY N+T PE++L + G + QGE IADNGGI AY AY+ WV ++G E LPGLD + +Q+FW SAANTWC++ E +K + GVH ++RV P SN EFAKDFKCP+GS MNPE KC +
Sbjct: 464 EFKKILDQVDWMDDETRKAALDKADSMSTHIAYPDELLDDTKLEQFYEKLEITPGNYLESILNLTLFGTQYSFEKLRKPVNKSDWVTHGRPAIVNAFYSSIENSIQFPAGILQGAFFSNDRPKYMNYGAIGFVMGHEITHGFDDQGRQFDKNGNLVEWWAAETKEKYLKRAQCIINQYGNYTAPEVSLNLNGINTQGENIADNGGIKEAYLAYNEWVRRNGAEPRLPGLDYSGQQMFWISAANTWCSKYRPETLKLRITTGVHSPGEFRVLGPLSNMDEFAKDFKCPVGSRMNPEKKCAV 763 HSP 2 Score: 249.21 bits (635), Expect = 6.085e-67 Identity = 151/485 (31.13%), Postives = 243/485 (50.10%), Query Frame = 0
Query: 5 NTLKTSVMMIPPKGKMDPALLKIGDSSILPCSTMKLLGITLQANLGWTDNVAGLVTISALLAVFVVNTVLDGAIEDELGIRLRGGPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRLIQ 489
N++K +V+ P K AL + G + I CS L+ I L LG A S + A ++ L + + G +IC +P C+ A +++NMD ++PC+DFY ++C F K +IPDD++SV+ S+++D++Q +LR +E R ++ ++ CM+ +E GL PL LK GGWP+ + G W + +K G++ +Y +G D KN+T + L Q LGL + L +G +K+V AYYNY D+A +LG + K L + ++FEI LAN + + +LYN MT+ +LTQK+P + W++Y + + + S + ++ V+V P + L L+ TP +Y++WRA TSV Y+N ++R + SG PRWK C+ S F + VG YV +F +AK EMV+ + F+ L Q
Sbjct: 3 NSMKQTVIKNPTWWKRRSALER-GLTIIAVCSV--LVAIALAIGLGVLARNAEPCESSLMSAEALIGAPLAKKVPQVVEKSPEG--DICLSPGCIHTASSILENMDQNVEPCDDFYRFACGSFLKNTIIPDDKTSVNTFSIISDKLQKQLRSSIEEESKPNDPRPFRLLKTLYKTCMNKTLIEEEGLNPLHKILKELGGWPVLVGDKWSDG-DFNWKESVYKFGKKGYSVDYFIDFSIGVDLKNSTKRVIDLDQASLGLSREYLSKGMDDKIVSAYYNYMVDIAEILGADR-EQAKIELKESLEFEIKLANISLPSEKRRNATALYNPMTVRQLTQKFPTIPWLEYFSTL---------LPSSITVTEDEMVIVNVPSFITDLEKLLEQTPKRIQANYVMWRAAATSVSYLNDEIRKRQLAYSTVISGRTEREPRWKECVDIVSGSFSISVGALYVRKYFNEDAKKNAVEMVSNIRGEFKKILDQ 471
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|1253756079|ref|XP_022662066.1| (membrane metallo-endopeptidase-like 1 isoform X2 [Varroa destructor] >gi|1253756081|ref|XP_022662067.1| membrane metallo-endopeptidase-like 1 isoform X2 [Varroa destructor] >gi|1268032003|ref|XP_022689225.1| membrane metallo-endopeptidase-like 1 isoform X2 [Varroa jacobsoni]) HSP 1 Score: 314.309 bits (804), Expect = 4.630e-90 Identity = 151/332 (45.48%), Postives = 213/332 (64.16%), Query Frame = 0
Query: 618 GLSGWISDLHVRP--HPHSKDYKL------------LTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
GLS +S+L+V+ H SKD+ L + +DWMD T RA K +I IGY ++N T + Y ++ + ++F+N + +W S+ QL + + W + Q A+VNAFY+ L N I PAGILQG F++++RPNYLN+G+IG++IGHE+THGFDD G+QFD++GN KNWWE++T+E+F+ +A C + QY N+TVPE+N+ + G + QGE IADNGGI A+ AY WV+ +G E LPGL+ T+ QLFW SAAN WC + E ++ G H A YRV P SN+ EFA+ F CP+GSPMNP+ KC +
Sbjct: 476 GLS--LSNLYVKNFFHEDSKDHALSMVKYITNEFLNIIKEVDWMDSATRLRAKNKAEAIVPYIGYPSELMNDTLLSDHYTNVSMKSDEYFKNVMQLRRWSTDYSFGQLRKPHIKGEWKKHAQVAVVNAFYNSLENCIEFPAGILQGAFFSKDRPNYLNFGAIGFVIGHEITHGFDDRGRQFDKDGNNKNWWEHETDEKFKGRAQCIIHQYGNYTVPEINMPVNGINTQGENIADNGGIKEAFRAYRQWVKDNGPEGSLPGLNYTADQLFWISAANVWCGKYRPEVMRLRTISGSHSPAPYRVIGPMSNTIEFAEQFNCPIGSPMNPKHKCTV 805 HSP 2 Score: 200.675 bits (509), Expect = 7.647e-50 Identity = 112/394 (28.43%), Postives = 202/394 (51.27%), Query Frame = 0
Query: 92 ICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLA-FFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGL-EYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
+C T CV AA ++I+NMD T +PC DFY ++C + +R IPDD+SS+++ S++ D++ +LR I ++ + + + + L +Q+C+++ ++ LG +PL L+ GGWP+ K +S W+Q +G++ + +F L V DF+N T ++ L Q LGL + L +G + +V+AY+ + A LLG T + L + FE LAN + + ++ +LYN M L EL + P ++W Y N + + I ++ + V P + ++ L++ T+ +Y++WR + S + R F +G ++PRW+ C+T+ + L + YV++ F ++KD MV +T F
Sbjct: 125 LCLTQGCVKAAAQIIENMDPTTNPCSDFYQFACGQWIQRQSIPDDKSSITQFSIIQDELDAKLRVIVEKPVNPKKDQPHVVNLKNLYQSCVNTSTLDRLGEEPLLKVLRELGGWPVVEGANWKGNSSFNWLQTIIAFRKLGYSHDIIFDLSVIPDFRNNTKHLIDLDQATLGLPDRTYLLKGMSDSVVKAYFKLMTEAASLLGAKNTDQTRKELEDALHFETMLANYSLPREERRNISALYNKMPLSELKKFSPTINWDLYFNSL-----------LVDHIDDDEMINVGVPNFIAQVAKLLQTVDKRTLANYMMWRVVLQSYATLGKAWRDQLHNFNSVLTGKTRENPRWEQCMTSLTGSLGLSLSNLYVKNFFHEDSKDHALSMVKYITNEF 507
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|1238876310|ref|XP_022251669.1| (membrane metallo-endopeptidase-like 1 [Limulus polyphemus]) HSP 1 Score: 306.99 bits (785), Expect = 6.817e-90 Identity = 148/312 (47.44%), Postives = 202/312 (64.74%), Query Frame = 0
Query: 624 SDLHVRPHPHSKDYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
S L + + H + K+L +DWMD +T RA K +I IGY D +LN + +Y +L L +FQN + W ++ QL + + W + +AA+VNA+Y+ L NSI PAGILQG FY ++RPNYLNYG+IG++IGHE+THGFDD G+QFD++GN NWWE +T+ +FR KA C ++QY N+TVPE L I G + QGE IADNGG+ AY AY +WV+ HG E LPGL T +QLFW SAAN WC + E +K + G H +++RV FSN EF++ F CP+ SPMNP+ +C +
Sbjct: 259 SSLEMVNYIHKEFLKILD-EVDWMDDKTRERAKEKAGTIQPYIGYPDELLNVDKVADIYENLTLTSNDYFQNVQNLRVWSTDYAFGQLRKPNKKGDWKKHARAAVVNAYYNSLENSIEFPAGILQGAFYEKDRPNYLNYGAIGFVIGHEITHGFDDRGRQFDKDGNNVNWWEPETDFKFRSKAKCIIEQYGNYTVPENGLQINGINTQGENIADNGGLKEAYRAYRSWVKDHGPERYLPGLKYTPEQLFWISAANVWCGKYRPEVLKLRILSGSHSPSQFRVIGTFSNLPEFSESFNCPVDSPMNPQKRCSV 569 HSP 2 Score: 117.087 bits (292), Expect = 2.197e-23 Identity = 71/283 (25.09%), Postives = 137/283 (48.41%), Query Frame = 0
Query: 202 GGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGL-EYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
GGWP+ + G++ W++ K G++ + L L V D++N +++I L QP LG+ + L +G + V AYY D AVLLG + + + + + FEI LAN + + ++ LYN M + E+ + P ++W ++ N++ + I ++ V+V PE+ ++ + + + +Y++WR + S ++ R + + +G +SPRW+ C+ + + + YV +HF E+K+ EMV + + F
Sbjct: 2 GGWPV-VEGELWDGSNFDWLETLFKFRKHGYSHDILLDLSVTPDYRNNSHHIVDLDQPVLGMPDRSYLIKGLNDSGVAAYYRLMVDSAVLLGATREA-AEEQMLESLNFEITLANFSLPREERRNISKLYNKMNITEIYKLAPSVNWREFFNKL-----------LVDPIPDSEPVIVDVPEFVKKFDDLITTIDKRVLANYMLWRVVLQSFAMLSKSWRELVQDYNTVITGKTRESPRWEKCMGTLTGSLGVALASLYVRNHFKEESKESSLEMVNYIHKEF 271
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|1004399804|gb|KYB27446.1| (Neprilysin-2-like Protein [Tribolium castaneum]) HSP 1 Score: 312.383 bits (799), Expect = 7.287e-90 Identity = 145/292 (49.66%), Postives = 193/292 (66.10%), Query Frame = 0
Query: 644 LDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
+DWMD ET AL K S++ I Y D +L+ ++ Y DL+L + ++ L+ + + + S+ +L Q ++ W + A+VNAFYS L NSI PAGILQG F++ NRP Y+NYG+IG++IGHE+THGFDD G+QFD+ GNL WW +T + + KA C +DQY N+TVPELN+ + G + QGE IADNGGI AY AY+ W ++HG E LPGL T Q+FW SAANTWC + E++K V G H +RV PFSN FAKDF CPLGS MNP+ KCK+
Sbjct: 469 VDWMDPETKKNALDKAKSMSTHIAYPDELLDDRKLEEFYGDLELDENYYLRSILNLTLFGTRFSFKRLRQPVNKTDWITHGRPAVVNAFYSALENSIQFPAGILQGVFFDANRPRYMNYGAIGFVIGHEITHGFDDQGRQFDKNGNLVEWWAPETKKAYLEKAQCIIDQYGNYTVPELNINLNGINTQGENIADNGGIKEAYLAYNKWTQRHGIEKTLPGLKYTPNQMFWISAANTWCAKYRPESLKLRVLTGYHSPGYFRVIGPFSNLDYFAKDFSCPLGSKMNPKKKCKV 760 HSP 2 Score: 228.409 bits (581), Expect = 1.327e-59 Identity = 122/394 (30.96%), Postives = 205/394 (52.03%), Query Frame = 0
Query: 91 EICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFR 484
+ C TP C+ A +++ MD ++DPC+DFY ++C F K IPDD+SSV+ SL++D +Q +LR + +E + + + ++ ++ACM+ +E GL+ +R L+ GGWP+ G W + ++ +G++ +Y VG D KN+T I L Q LGL + L +G+ +K+V AYY Y D+AVL G K + L + + FE+ LAN + + +LYN MT+ EL +K+P + WV+Y+N + + QI ++ VVV P+Y + TP +Y++WRA +SV Y+ +R ++ +G RWK C+ ++ + G YV +F +A+ EMV+ + F+
Sbjct: 81 KTCLTPGCIHTASTVLKYMDPSVDPCDDFYQFTCGNFLKTTNIPDDKSSVTSFSLISDTLQEQLRTMIEEPIKPDEPKPFQLTKKLYKACMNKTLIEKDGLKTIRTILRQLGGWPVLEGDDWSAG-EFDWRRSVYRFRRMGYSVDYFIDFSVGIDLKNSTRRIIDLDQASLGLRREFLTKGFSDKLVNAYYEYMVDIAVLFGADKERAAEE-LKESLLFEMRLANISLPSEKRRNATALYNPMTIDELQRKFPSIPWVEYMNTLLAPDT---------QITHDEIVVVSVPKYLTDFEALISRTPKRVQANYVMWRAAASSVSYLTEDLRKRQLEYTTVVTGRTERESRWKECIDISAGSLSIAAGALYVRKYFNEQARQNALEMVSDIRAEFQ 463
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|644996757|ref|XP_008208160.1| (PREDICTED: membrane metallo-endopeptidase-like 1 isoform X2 [Nasonia vitripennis]) HSP 1 Score: 313.923 bits (803), Expect = 8.320e-90 Identity = 140/300 (46.67%), Postives = 203/300 (67.67%), Query Frame = 0
Query: 636 DYKLLTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
++K + +DWMD ET AL K +S++ I Y D +L+ T ++ Y L++ P + ++ L+ + + + S+ +L + ++ W + AIVNAFYS + NSI PAGILQG F++ +RP Y+NYG+IG+++GHE+THGFDD G+QFD+ GNL WW +T E++ +A C ++QY N+T PE++L + G + QGE IADNGGI AY AY+ WV ++G E LPGLD + +Q+FW SAANTWC++ E +K + GVH ++RV P SN EFAKDFKCP+GS MNPE KC +
Sbjct: 519 EFKKILDQVDWMDDETRKAALDKADSMSTHIAYPDELLDDTKLEQFYEKLEITPGNYLESILNLTLFGTQYSFEKLRKPVNKSDWVTHGRPAIVNAFYSSIENSIQFPAGILQGAFFSNDRPKYMNYGAIGFVMGHEITHGFDDQGRQFDKNGNLVEWWAAETKEKYLKRAQCIINQYGNYTAPEVSLNLNGINTQGENIADNGGIKEAYLAYNEWVRRNGAEPRLPGLDYSGQQMFWISAANTWCSKYRPETLKLRITTGVHSPGEFRVLGPLSNMDEFAKDFKCPVGSRMNPEKKCAV 818 HSP 2 Score: 246.128 bits (627), Expect = 1.986e-65 Identity = 145/465 (31.18%), Postives = 233/465 (50.11%), Query Frame = 0
Query: 25 LKIGDSSILPCSTMKLLGITLQANLGWTDNVAGLVTISALLAVFVVNTVLDGAIEDELGIRLRGGPEICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLAFFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGLEYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAFRIRLIQ 489
L+ G + I CS L+ I L LG A S + A ++ L + + G +IC +P C+ A +++NMD ++PC+DFY ++C F K +IPDD++SV+ S+++D++Q +LR +E R ++ ++ CM+ +E GL PL LK GGWP+ + G W + +K G++ +Y +G D KN+T + L Q LGL + L +G +K+V AYYNY D+A +LG + K L + ++FEI LAN + + +LYN MT+ +LTQK+P + W++Y + + + S + ++ V+V P + L L+ TP +Y++WRA TSV Y+N ++R + SG PRWK C+ S F + VG YV +F +AK EMV+ + F+ L Q
Sbjct: 77 LERGLTIIAVCSV--LVAIALAIGLGVLARNAEPCESSLMSAEALIGAPLAKKVPQVVEKSPEG--DICLSPGCIHTASSILENMDQNVEPCDDFYRFACGSFLKNTIIPDDKTSVNTFSIISDKLQKQLRSSIEEESKPNDPRPFRLLKTLYKTCMNKTLIEEEGLNPLHKILKELGGWPVLVGDKWSDG-DFNWKESVYKFGKKGYSVDYFIDFSIGVDLKNSTKRVIDLDQASLGLSREYLSKGMDDKIVSAYYNYMVDIAEILGADR-EQAKIELKESLEFEIKLANISLPSEKRRNATALYNPMTVRQLTQKFPTIPWLEYFSTL---------LPSSITVTEDEMVIVNVPSFITDLEKLLEQTPKRIQANYVMWRAAATSVSYLNDEIRKRQLAYSTVISGRTEREPRWKECVDIVSGSFSISVGALYVRKYFNEDAKKNAVEMVSNIRGEFKKILDQ 526
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|1268032005|ref|XP_022689226.1| (membrane metallo-endopeptidase-like 1 isoform X3 [Varroa jacobsoni]) HSP 1 Score: 313.538 bits (802), Expect = 8.364e-90 Identity = 151/332 (45.48%), Postives = 213/332 (64.16%), Query Frame = 0
Query: 618 GLSGWISDLHVRP--HPHSKDYKL------------LTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
GLS +S+L+V+ H SKD+ L + +DWMD T RA K +I IGY ++N T + Y ++ + ++F+N + +W S+ QL + + W + Q A+VNAFY+ L N I PAGILQG F++++RPNYLN+G+IG++IGHE+THGFDD G+QFD++GN KNWWE++T+E+F+ +A C + QY N+TVPE+N+ + G + QGE IADNGGI A+ AY WV+ +G E LPGL+ T+ QLFW SAAN WC + E ++ G H A YRV P SN+ EFA+ F CP+GSPMNP+ KC +
Sbjct: 475 GLS--LSNLYVKNFFHEDSKDHALSMVKYITNEFLNIIKEVDWMDSATRLRAKNKAEAIVPYIGYPSELMNDTLLSDHYTNVSMKSDEYFKNVMQLRRWSTDYSFGQLRKPHIKGEWKKHAQVAVVNAFYNSLENCIEFPAGILQGAFFSKDRPNYLNFGAIGFVIGHEITHGFDDRGRQFDKDGNNKNWWEHETDEKFKGRAQCIIHQYGNYTVPEINMPVNGINTQGENIADNGGIKEAFRAYRQWVKDNGPEGSLPGLNYTADQLFWISAANVWCGKYRPEVMRLRTISGSHSPAPYRVIGPMSNTIEFAEQFNCPIGSPMNPKHKCTV 804 HSP 2 Score: 200.675 bits (509), Expect = 7.097e-50 Identity = 112/394 (28.43%), Postives = 202/394 (51.27%), Query Frame = 0
Query: 92 ICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLA-FFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGL-EYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
+C T CV AA ++I+NMD T +PC DFY ++C + +R IPDD+SS+++ S++ D++ +LR I ++ + + + + L +Q+C+++ ++ LG +PL L+ GGWP+ K +S W+Q +G++ + +F L V DF+N T ++ L Q LGL + L +G + +V+AY+ + A LLG T + L + FE LAN + + ++ +LYN M L EL + P ++W Y N + + I ++ + V P + ++ L++ T+ +Y++WR + S + R F +G ++PRW+ C+T+ + L + YV++ F ++KD MV +T F
Sbjct: 124 LCLTQGCVKAAAQIIENMDPTTNPCSDFYQFACGQWIQRQSIPDDKSSITQFSIIQDELDAKLRVIVEKPVNPKKDQPHVVNLKNLYQSCVNTSTLDRLGEEPLLKVLRELGGWPVVEGANWKGNSSFNWLQTIIAFRKLGYSHDIIFDLSVIPDFRNNTKHLIDLDQATLGLPDRTYLLKGMSDSVVKAYFKLMTEAASLLGAKNTDQTRKELEDALHFETMLANYSLPREERRNISALYNKMPLSELKKFSPTINWDLYFNSL-----------LVDHIDDDEMINVGVPNFIAQVAKLLQTVDKRTLANYMMWRVVLQSYATLGKAWRDQLHNFNSVLTGKTRENPRWEQCMTSLTGSLGLSLSNLYVKNFFHEDSKDHALSMVKYITNEF 506
BLAST of neprilysin-2-like isoform x3 vs. nr
Match: gi|1253756083|ref|XP_022662068.1| (membrane metallo-endopeptidase-like 1 isoform X3 [Varroa destructor]) HSP 1 Score: 313.538 bits (802), Expect = 8.450e-90 Identity = 151/332 (45.48%), Postives = 213/332 (64.16%), Query Frame = 0
Query: 618 GLSGWISDLHVRP--HPHSKDYKL------------LTGMLDWMDKETASRALIKLNSINELIGYDDVILNTTAMDYLYRDLDLHPKQFFQNALSRSKWWLKDSWNQLNQSTSEDPWPEFDQAAIVNAFYSPLSNSINLPAGILQGKFYNENRPNYLNYGSIGYIIGHELTHGFDDSGKQFDEEGNLKNWWENKTNEEFRFKADCFVDQYSNFTVPELNLTIEGKHIQGEGIADNGGIMHAYDAYSAWVEKHGEESILPGLDLTSKQLFWASAANTWCTESNTENIKYNVKYGVHPLAKYRVNVPFSNSREFAKDFKCPLGSPMNPELKCKI 935
GLS +S+L+V+ H SKD+ L + +DWMD T RA K +I IGY ++N T + Y ++ + ++F+N + +W S+ QL + + W + Q A+VNAFY+ L N I PAGILQG F++++RPNYLN+G+IG++IGHE+THGFDD G+QFD++GN KNWWE++T+E+F+ +A C + QY N+TVPE+N+ + G + QGE IADNGGI A+ AY WV+ +G E LPGL+ T+ QLFW SAAN WC + E ++ G H A YRV P SN+ EFA+ F CP+GSPMNP+ KC +
Sbjct: 475 GLS--LSNLYVKNFFHEDSKDHALSMVKYITNEFLNIIKEVDWMDSATRLRAKNKAEAIVPYIGYPSELMNDTLLSDHYTNVSMKSDEYFKNVMQLRRWSTDYSFGQLRKPHIKGEWKKHAQVAVVNAFYNSLENCIEFPAGILQGAFFSKDRPNYLNFGAIGFVIGHEITHGFDDRGRQFDKDGNNKNWWEHETDEKFKGRAQCIIHQYGNYTVPEINMPVNGINTQGENIADNGGIKEAFRAYRQWVKDNGPEGSLPGLNYTADQLFWISAANVWCGKYRPEVMRLRTISGSHSPAPYRVIGPMSNTIEFAEQFNCPIGSPMNPKHKCTV 804 HSP 2 Score: 200.675 bits (509), Expect = 7.031e-50 Identity = 112/394 (28.43%), Postives = 202/394 (51.27%), Query Frame = 0
Query: 92 ICQTPNCVMAAQELIQNMDLTLDPCEDFYAYSCSGFQKRLMIPDDRSSVSETSLLADQVQYELRQIFDETLPLESSRGAKIPLA-FFQACMDSKEVENLGLQPLRDFLKIPGGWPLGPKMRTKKGTSTTWVQLAHKLMDVGFTGNYLFGLDVGTDFKNTTNNIFFLAQPRLGL-EYKELKEGWKNKMVQAYYNYTYDMAVLLGEPKTTDLKSTLTKMIQFEINLANATRSWADVSDVDSLYNLMTLGELTQKYPFLSWVQYVNQVGRSKSEVAQMYSLFQIQSNQEVVVLDPEYFERLTMTLKSTPDTTIQSYIIWRAIKTSVPYMNSQVRAVASQFYRQFSGTRSDSPRWKGCLTATSNFFPLLVGKFYVESHFPPEAKDKVSEMVALVTEAF 483
+C T CV AA ++I+NMD T +PC DFY ++C + +R IPDD+SS+++ S++ D++ +LR I ++ + + + + L +Q+C+++ ++ LG +PL L+ GGWP+ K +S W+Q +G++ + +F L V DF+N T ++ L Q LGL + L +G + +V+AY+ + A LLG T + L + FE LAN + + ++ +LYN M L EL + P ++W Y N + + I ++ + V P + ++ L++ T+ +Y++WR + S + R F +G ++PRW+ C+T+ + L + YV++ F ++KD MV +T F
Sbjct: 124 LCLTQGCVKAAAQIIENMDPTTNPCSDFYQFACGQWIQRQSIPDDKSSITQFSIIQDELDAKLRVIVEKPVNPKKDQPHVVNLKNLYQSCVNTSTLDRLGEEPLLKVLRELGGWPVVEGANWKGNSSFNWLQTIIAFRKLGYSHDIIFDLSVIPDFRNNTKHLIDLDQATLGLPDRTYLLKGMSDSVVKAYFKLMTEAASLLGAKNTDQTRKELEDALHFETMLANYSLPREERRNISALYNKMPLSELKKFSPTINWDLYFNSL-----------LVDHIDDDEMINVGVPNFIAQVAKLLQTVDKRTLANYMMWRVVLQSYATLGKAWRDQLHNFNSVLTGKTRENPRWEQCMTSLTGSLGLSLSNLYVKNFFHEDSKDHALSMVKYITNEF 506 The following BLAST results are available for this feature:
BLAST of neprilysin-2-like isoform x3 vs. L. salmonis genes
Analysis Date: 2018-04-19 (T. kinsejongensis vs L. Salmonis peptides) Total hits: 21
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BLAST of neprilysin-2-like isoform x3 vs. SwissProt
Analysis Date: 2018-04-19 (T. kingejongensis peptided Blastp vs. SwissProt) Total hits: 25
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BLAST of neprilysin-2-like isoform x3 vs. nr
Analysis Date: 2018-05-15 (T. kingsejongensis proteins Blastp vs. NR) Total hits: 25
Pagesback to topAlignments
The following features are aligned
Analyses
This gene is derived from or has results from the following analyses
Properties
Relationships
The following mRNA feature(s) are a part of this gene:
Sequences
The following sequences are available for this feature:
gene from alignment at scaffold75_size407189:374287..389647+ Legend: mRNA Hold the cursor over a type above to highlight its positions in the sequence below.>maker-scaffold75_size407189-snap-gene-3.15 ID=maker-scaffold75_size407189-snap-gene-3.15|Name=neprilysin-2-like isoform x3|organism=Tigriopus kingsejongensis|type=gene|length=15361bp|location=Sequence derived from alignment at scaffold75_size407189:374287..389647+ (Tigriopus kingsejongensis)back to top Synonyms
The feature 'neprilysin-2-like isoform x3' has the following synonyms
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