3-hydroxy-3-methylglutaryl- reductase, snap_masked-scaffold208_size258758-processed-gene-1.0 (gene) Tigriopus kingsejongensis

Overview


Name	3-hydroxy-3-methylglutaryl- reductase
Unique Name	snap_masked-scaffold208_size258758-processed-gene-1.0
Type	gene
Organism	Tigriopus kingsejongensis (Tigriopus kingsejongensis)

Associated RNAi Experiments

Nothing found

Homology

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. L. salmonis genes
Match: EMLSAG00000004979 (supercontig:LSalAtl2s:LSalAtl2s260:1508384:1510927:-1 gene:EMLSAG00000004979 transcript:EMLSAT00000004979 description:"augustus_masked-LSalAtl2s260-processed-gene-14.5")

HSP 1 Score: 749.969 bits (1935), Expect = 0.000e+0
Identity = 427/915 (46.67%), Postives = 576/915 (62.95%), Query Frame = 0

Query:   34 RSLPTLFIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQIINTLPGED--GQTPVVHRVKVVATALLMIAHII-FRPPFLFSSASGISQPTTTLFSWATTNIEKVLITVVIVALSIKYLFYEDMDE---AQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASR---HGDDSSSESAWSEVGYLPDLKDQEAQTTD---MASSEDEVDDDENGEKRRIRH-----HHQLPKEPRSLEECTKIYKGTMDGVEY--LIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYV---EKVAKRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVV---GDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVA 922
            R  P  F+  +    G+    QPWEV+  +   L+ ++T                       +P D        S +W   +V   F  L++L +  + K+IH + S ++ ++A  Y    + L ++  + +G P       A F + LL D+ K+T++ Q+ALS++H   + + ++  M  L PT   D L K+             L       V ++++   V+   YP  LS+ L L+    G+ +W+V++I+ TLP ++   +TP+    +V+A  +L++ H+   +PP L                    N   ++I++ +V LS  Y FY + DE   +  LRK+Y E  TRK     +Q+      K ++DR S STDEGI +  SA        S+    GDDSSSESAWSEV Y+PDLKDQEAQTT+   + SS DE  D+   E     H     HH     PRS+E C  I K      E   L DEEVV LVE++ IR+HALE VLN+  RGV +RRK +   E+  ++    LP+++FDY TVMGACCESV+GYM +PVG+ GPL LD +L+++PMATTEGCLVAS NRGCSAL  CG VTS+I  DGM+RGP+VRFPN++   +AK+W+E+P N+ +IK +FDSTSRFARL +LK++ AGR +Y+RFVA TGDAMGMNM+SKA EF+L +L  +FPEM+++S+SGNMCTDKKPAA+NW++GRGKSV+CEA VP  IVET+LKTS AAL DLN +KN  GSAMAGSIGGFNA +AN+VTA+FIATGQDAAQN+ SSNC+T ++     G DLY+TCTMPSIEVGT+GGGTIL  QG+CL++LGVKG  P SPG N++QLA ++C  VLAGELSLMSALAAG LV SHLRHNRS LAVG +A
Sbjct:    3 RRPPLKFLEDVSDCLGQATVKQPWEVLFVSLTSLLSLVTF----------------------VPLDGG------SPEWSPVVVFV-FRFLSLLRMYVQLKRIHRLGSAVLLHVAGLY----AFLLSMTAFLLGGP------DAAFSVLLLSDIPKMTQLTQYALSATHESCLPDRLSRAMQTLLPTLLYDTLLKL--------LLFTLLPLLVSSVVFALLLQAFVFAFVYPPLLSIALXLITSPQGQAKWNVKRILETLPTQEPPSRTPL----RVLAFPVLVLLHLTCLQPPSL---------------QLHIQNTPHIIISLSLVLLS--YYFYSNKDEDATSLHLRKSYEEAFTRKL---QDQDSSVSRLKDDLDRASQSTDEGIGLTKSANSASDLKKSKILVVGDDSSSESAWSEV-YMPDLKDQEAQTTEECLVVSSSDEDRDETLSEDGSSSHLLSGDHHS---PPRSIERCLLILKENAQRNEPCPLTDEEVVTLVEERHIRSHALEKVLNDHLRGVVVRRKLISRREQHLQKAFEKLPYKHFDYHTVMGACCESVVGYMPVPVGLVGPLQLDNKLYHIPMATTEGCLVASTNRGCSALSKCGGVTSQITDDGMSRGPVVRFPNVSAAKKAKDWLEDPVNYQEIKDSFDSTSRFARLNKLKVRLAGRLMYLRFVAKTGDAMGMNMLSKATEFALNKLHFIFPEMQIISISGNMCTDKKPAAVNWIEGRGKSVVCEAIVPASIVETILKTSTAALVDLNSAKNQTGSAMAGSIGGFNAHSANIVTAIFIATGQDAAQNIGSSNCMTLMEPWGPDGKDLYITCTMPSIEVGTIGGGTILAPQGSCLEMLGVKGPHPTSPGENSRQLARIICGAVLAGELSLMSALAAGXLVSSHLRHNRSTLAVGKLA 842

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|391359371|sp|A7Z064.2|HMDH_BOVIN (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 688.723 bits (1776), Expect = 0.000e+0
Identity = 387/936 (41.35%), Postives = 555/936 (59.29%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR------PPFLFSSASGIS-----------QPTTTLFSW-----ATTNIEKVLITVVIVALSIKYLFYEDMDEAQEL------------RKTYIEELTR----------KFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKR--DIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T      ++KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LLVD+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R      P    +  S +S           +P+ +L+ +      + +IE+V+   + + L++KY+F+E  +    L            +K   ++  R          KF    E+   NR  KVE+ +                   P  A    ++ +S  A   VG            + +  +  E++  E           +LP EPR  EEC +I +    G ++L D E++ LV  K I A+ LE+++    RGV IRR+ + K       +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LDG+ F VPMATTEGCLVAS NRGC A+   G  +SR+LADGMTRGP+VRFP     AE K W+E PE F  IK  FDSTSRFARLQ+L +  AGR LYIRF + +GDAMGMNMISK  E +L +L + FPEM+++++SGN CTDKKPAAINW++GRGKSV+CEA +P  +V  VLKT+  A+ ++N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLV+SH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFT-----GNNKICGWNYECPKLEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLVDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKITDDCCRRDPVLVRNDQKFHAMEEETRKNRERKVEVIK-------------------PLLA----ENDTSHRATFVVG-----------NSSLLGTSLELETQE--------PEMELPVEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRFPRACDSAEVKAWLETPEGFTVIKEAFDSTSRFARLQKLHMSVAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLQEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACRDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQG 881

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|2495262|sp|Q29512.1|HMDH_RABIT (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 686.411 bits (1770), Expect = 0.000e+0
Identity = 391/923 (42.36%), Postives = 554/923 (60.02%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR------PPFLFSSASGIS-----------QPTTTLFSW-----ATTNIEKVLITVVIVALSIKYLFYEDMDEAQELR-KTYIEE--LTRKFAEDS---EQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGY-LPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKR--DIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTC---GVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T  D     KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R      P    +  S +S           +P+ +L+ +      + +IE+V+   + + L++KY+F+E  +    L  K  I    +T+K   DS    +    R N+      S   + G+S     +   P  A     DS   +A+   G   PD       +  + + E E++               LPKEPR  EEC +I      G ++L D E++ LV  K I A+ LE+++    RGV IRR+ + K       +  LP+R+++Y  V+GACCE+VIGYM +PVGV GPL LDG+ F VPMATTEGCLVAS NRGC A+  C   G +SR+LADGMTRGP+VR P     AE K W+E PE F  IK  FDSTSRFARLQ+L +  AGR LYIRF + TGDAMGMNMISK  E +L +L + FPEM+++++SGN CTDKKPAA+NW++GRGK+V+CEA +P  +V  VLKT+  A+ D+N +KNLVGSAMAGSIGG+NA AAN VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    SPG NA+QLA +VC TV+AGELSLM+ALAAGHLVKSH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFTGND-----KICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVPDSCCRREPVVVRNNQ---KFCSVEEEAGMSQDRKVEVIKPLVAE---TDSPHRAAFVVGGSSFPD------TSLVLETKEPEIE---------------LPKEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVLGACCENVIGYMPIPVGVVGPLCLDGKEFQVPMATTEGCLVASTNRGCRAI--CLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLHISMAGRNLYIRFQSRTGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAANYVTAIYIACGQDAAQNVGSSNCITLMEASGPPNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDSPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLEG 881

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|118573790|sp|Q1W675.1|HMDH_PIG (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 682.559 bits (1760), Expect = 0.000e+0
Identity = 388/937 (41.41%), Postives = 550/937 (58.70%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR------PPFLFSSASGIS-----------QPTTTLFSW-----ATTNIEKVLITVVIVALSIKYLFYEDMDEAQEL------------RKTYIEELTR----------KFAEDSEQEEFNRGNKVEMDR-VSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKR--DIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T  D     KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+  + V++TF+PA +SLVLEL     +GRP W +      L GE+ +  PV  RVK++ +  L++ H   R      P    +  S +S           +P+ +L+ +      + +IE+V+   + + L++KY+F+E  +    L            +K   ++  R          KF    E+   NR  KVE+ + +   TD           RP         DSS E           L+ QE +                          Q+P EPR  EEC +I      G ++L D E++ LV  K I A+ LE+++    RGV IRR+ + K       +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LDG+ F VPMATTEGCLVAS NRGC A+   G  +SRILADGMT  P+VRFP     AE K W+E PE F  IK  FDSTSRFARLQ+L++  AGR LYIRF + +GDAMGMNMISK  E +L +L + FPEM+++++SGN CTDKKPAA+NW++GRGKSV+CEA +P  +V  VLKT+  A+ ++N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLV+SH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFTGND-----KICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLATYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEGEENKPNPVTQRVKIIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLTLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVTDDCCRREPTLVRNDQKFHTVEEEARINRERKVEVIKPLVAETD--------TSSRPTFVVGNSTLDSSLE-----------LEMQEPEI-------------------------QIPSEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMT--PVVRFPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLQMSVAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMVEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTSLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQG 878

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|123343|sp|P04035.1|HMDH_HUMAN (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 681.404 bits (1757), Expect = 0.000e+0
Identity = 387/919 (42.11%), Postives = 554/919 (60.28%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR------PPFLFSSASGIS-----------QPTTTLFSW-----ATTNIEKVLITVVIVALSIKYLFYEDMDEAQELR-KTYIEE--LTRKFAEDS--EQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKR--DIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T      ++KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R      P    +  S +S           +P+ +L+ +      + +IE+V+   + + L++KY+F+E  +    L  K  I    +T+K   D+   +E     N  + D V   T  GI+     +   P  A    +  +   A   VG    L D    ++ + + E E++               LP+EPR  EEC +I      G ++L D E++ LV  K I A+ LE+++    RGV IRR+ + K       +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LD + F VPMATTEGCLVAS NRGC A+   G  +SR+LADGMTRGP+VR P     AE K W+E  E F  IK  FDSTSRFARLQ+L    AGR LYIRF + +GDAMGMNMISK  E +L +L + FPEM+++++SGN CTDKKPAAINW++GRGKSV+CEA +P  +V  VLKT+  A+ ++N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLVKSH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFT-----GNNKICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEET--GINRERKVEVIKPLVA----ETDTPNRATFVVGN-SSLLDT---SSVLVTQEPEIE---------------LPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQG 881

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|123344|sp|P09610.1|HMDH_MESAU (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 681.019 bits (1756), Expect = 0.000e+0
Identity = 382/921 (41.48%), Postives = 554/921 (60.15%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR------PPFLFSSASGIS-----------QPTTTLFSW-----ATTNIEKVLITVVIVALSIKYLFYEDMDEAQELR-KTYIEE--LTRKFAEDS---EQEEFNRGNKVEMDRVSNSTDE-GISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKR--DIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T      ++KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R      P    +  S +S           +P+ +L+ +      + +IE+V+   +   L++KY+F+E  +    L  K  I     T K A D+    +   +R N    +++S+  +E G++     +   P  A       ++    +  G  P           + + E E++               LP EPR  EEC +I +    G ++L D E++ LV  K I A+ LE+++    RGV IRR+ +         +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LDG+ + VPMATTEGCLVAS NRGC A+   G  +SR+LADGMTRGP+VR P     AE K W+E PE F  IK  FDSTSRFARLQ+L +  AGR LYIRF + TGDAMGMNMISK  E +L +L + FPEM+++++SGN CTDKKPAA+NW++GRGK+V+CEA +P  +V  VLKT+  A+ D+N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLV+SH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFT-----GNNKICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTTEHSKVSLGLDEDVSKRIEPSVSLWQFYLSKMISMDIEQVVTLSLAFLLAVKYIFFEQAETESTLSLKNPITSPVATPKKAPDNCCRREPVLSRRN----EKLSSVEEEPGVNQDRKVEVIKPLVAETESTSRATFVLGASGGCSP---------VALGTQEPEIE---------------LPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSTKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKDAFDSTSRFARLQKLHVTMAGRNLYIRFQSKTGDAMGMNMISKGTEKALVKLQEFFPEMQILAVSGNYCTDKKPAAVNWIEGRGKTVVCEAVIPARVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQG 880

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|123347|sp|P20715.1|HMDH_XENLA (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 680.248 bits (1754), Expect = 0.000e+0
Identity = 386/929 (41.55%), Postives = 554/929 (59.63%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ--TPVVHRVKVVATALLMIAHIIFR---PPFLFSSASGISQPTTTLFS-------------W-------ATTNIEKVLITVVIVALSIKYLFYEDMDEAQE------------LRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVD-DDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYV-EKVAKRD-IGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG+F AS PWEVIV T    IC++++      M T  D     KI     + P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ K + + +FALSS+    + +N+A GM +L PTF L+ L +  ++G+G+++ + QLE    +  +SV+ N+  ++TF+PA +SLVLEL     +GRP W + Q  + L  E+     PV  RVK++ +  L++ H   R    P   +S S      TT+               W        T ++E+++   + + L++KY+F+E  +                ++K  IE   R+   + EQE+           V  ST E                    + SS E   + +  LP     +A+     SS  E+  +D+N           LP+EPR L+EC +I K    G +YL D EV+ LV  K I A+ LE+++ +P  GV IRR+ + +K+ +R  + +LP++N++Y  VMGACCE+VIGYM +PVGVAGPL L+ + + VPMATTEGCLVAS NRGC A+   G   SR+LADGMTRGP+VR P     AE K W++  E F  IK  FDSTSRFARL RL+   AGR LYIRF + TGDAMGMNMISK  E +L +L + FP++ ++++SGN CTDKKPAAINW++GRGKSV+CEA +P  +V  VLK+S  AL ++N +KN +GSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA QLA +VC+TV+AGELSLM+ALAAGHLVKSH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGQFVASHPWEVIVGTVTLTICMMSMN-----MFTGND-----KICGWNYACPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSKASALAKFALSSNSQDEVRDNIARGMAILGPTFTLEALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFAFMTFFPACVSLVLELSRESREGRPIWQLSQFASVLEEEEDNKPNPVTQRVKMIMSLGLVLVHAHSRWISEPSSQNSTSISDHEVTTMLDDMMPKRVEPSMPLWQFYLSRMVTMDVEQIITLGLALLLAVKYIFFEQTETESTFSMKNPIISPVAVQKKQIESCCRR---EPEQEK----------TVHVSTTE--------------------EASSKEETEAVIKPLPLETSPKAKFIVGDSSPLELSPEDKN-------TMFDLPEEPRPLDECVRILKNPDKGAQYLTDAEVISLVNAKHIPAYKLETMMESPREGVAIRRQMLSDKLPQRSALQSLPYKNYNYSLVMGACCENVIGYMPIPVGVAGPLLLNNKEYQVPMATTEGCLVASTNRGCRAIMLGGGAKSRVLADGMTRGPVVRLPTACDAAEVKAWLDSAEGFKVIKDAFDSTSRFARLGRLQNCVAGRNLYIRFQSKTGDAMGMNMISKVTEQALARLQEEFPDLHVLAVSGNYCTDKKPAAINWIEGRGKSVVCEAIIPAKVVREVLKSSTEALVEVNINKNFIGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITIMEATGPTYEDLYISCTMPSIEIGTVGGGTNLAPQQACLQMLGVQGASTETPGKNACQLAQIVCSTVMAGELSLMAALAAGHLVKSHMVHNRSKINLQDLPG 876

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|118573791|sp|P51639.2|HMDH_RAT (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 679.863 bits (1753), Expect = 0.000e+0
Identity = 385/921 (41.80%), Postives = 556/921 (60.37%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR------PPFLFSSASGIS-----------QPTTTLFSW-----ATTNIEKVLITVVIVALSIKYLFYEDMDEAQELR-KTYIEE--LTRKFAEDS----EQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVE-KVAK-RDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T      ++KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R      P    +  S +S           +P+ +L+ +      + +IE+V+   + + L++KY+F+E  +    L  K  I    +T K A+D+    E     R  K+     S   D G++     +   P  A    +  +S  A   +G               AS    +   E G         +LP EPR  EEC +I +    G ++L D E++ LV  K I A+ LE+++    RGV IRR+ +  K+A+   +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LDG+ + VPMATTEGCLVAS NRGC A+   G  +SR+LADGM+RGP+VR P     AE K W+E PE F  +K  FDSTSRFARLQ+L +  AGR LYIR  + TGDAMGMNMISK  E +L +L + FPE++++++SGN CTDKKPAAINW++GRGK+V+CEA +P  +V  VLKT+  A+ D+N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLV+SH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFT-----GNNKICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTPKKAQDNCCRREPLLVRRNQKLS----SVEEDPGVNQDRKVEVIKPLVA----EAETSGRATFVLG------------ASAASPPLALGAQEPG--------IELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACDSAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMISKGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQG 880

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|83305798|sp|Q5R6N3.1|HMDH_PONAB (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 677.552 bits (1747), Expect = 0.000e+0
Identity = 386/919 (42.00%), Postives = 553/919 (60.17%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR------PPFLFSSASGIS-----------QPTTTLFSW-----ATTNIEKVLITVVIVALSIKYLFYEDMDEAQELR-KTYIEE--LTRKFAEDS--EQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKR--DIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T      ++KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R      P    +  S +S           +P+ +L+ +      + +IE+V+   + + L++KY+F+E  +    L  K  I    +T+K   D    +E     N  + D V   T  GI+     +   P  A    +  +   A   VG    L D    ++ + + E E++               LP+EPR  EEC +I      G ++L D E++ LV  K I A+ LE+++    RGV IRR+ + K       +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LDG+ F VPMATTEGCLVAS NRGC A+   G  +SR+LADGMTRGP+VR P     AE K W+E  E F  IK  FDSTSRFARL++L    AGR LYIRF + +GDAMGMNMISK  E +L +L + FPEM+++++SGN CTDKKPAAINW++GRGKS +CEA +P  +V  VLKT+  A+ ++N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLVKSH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFT-----GNNKICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWLLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDDCCRREPMLVRNNQKCDSVEEET--GINRERKVEVIKPLVA----ETDTPNRATFVVGN-SSLLDT---SSVLVTQEPEIE---------------LPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVIAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLRKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSAVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQG 881

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|123341|sp|P00347.1|HMDH_CRIGR (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 677.167 bits (1746), Expect = 0.000e+0
Identity = 380/908 (41.85%), Postives = 543/908 (59.80%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR---PPFLFSSASGISQPTTTLFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEE-FNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDL-KDQEAQT-------TDMASSEDEVDDDENGE----KRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKR--DIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T      ++KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R    P   +S +  S+ +  L    +  IE    +V +    +  +   D+++   L   ++  +   F E +E E   +  N +    V+             K  P +C  R           S V   P + +D++ +        T+ AS    V            R      +LP EPR  EEC +I +    G ++L D E++ LV  K I A+ LE+++    RGV IRR+ +         +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LDG+ + VPMATTEGCLVAS NRGC A+   G  +SR+LADGMTRGP+VR P     AE K W+E PE F  IK  FDSTSRFARLQ+L +  AGR LYIRF + TGDAMGMNMISK  E +L +L + FPEM+++++SGN CTDKKPAAINW++GRGK+V+CEA +P  +V  VLKT+  A+ D+N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLV+SH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFT-----GNNKICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTTEHSKVSLGLDEDVSKRIEP---SVSLWQFYLSKMISMDIEQVVTLSLAFLLAVKYIFFEQAETESTLSLKNPITSPVVT------------PKKAPDNCCRREPLLVRRSEKLSSVEEEPGVSQDRKVEVIKPLVVETESASRATFVLGASGTSPPVAARTQELEIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSTKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKDAFDSTSRFARLQKLHVTMAGRNLYIRFQSKTGDAMGMNMISKGTEKALLKLQEFFPEMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQG 880

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Match: gi|408360266|sp|Q01237.3|HMDH_MOUSE (RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase)

HSP 1 Score: 677.167 bits (1746), Expect = 0.000e+0
Identity = 383/912 (42.00%), Postives = 553/912 (60.64%), Query Frame = 0

Query:   40 FIRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMY-CTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFR---PPFLFSSASGISQPTTTLFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEE-FNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQ-------EAQTTD---------MASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVE-KVAK-RDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCG-VTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVVG---DDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAG 923
             + ++F+ HG F AS PWEVIV T    IC++++      M T      ++KI       P    +  S D I   ++    C+A+L+I ++F+ +  + S  I  IA  +  F+S +++ ++    +     L++A     LL+D+ + + + +FALSS+    + EN+A GM +L PTF LD L +  ++G+G+++ + QLE    +  +SV+ N+ V++TF+PA +SLVLEL     +GRP W +      L  E+ +  PV  RVK++ +  L++ H   R    P   +S +  ++ +  L    +  IE    +V +    +  +   D+++   L   ++  +   F E +E E   +  N +    V++   +      +   R P    R+   SS E    + G   + K +       EA+TT          +AS    +   E G         +LP EPR  EEC +I +    G ++L D E++ LV  K I A+ LE+++    RGV IRR+ +  K+A+   +  LP+R+++Y  VMGACCE+VIGYM +PVGVAGPL LDG+ + VPMATTEGCLVAS NRGC A+   G  +SR+LADGMTRGP+VR P     AE K W+E PE F  IK  FDSTSRFARLQ+L +  AGR LYIRF + TGDAMGMNMISK  E +L +L + FP+M+++++SGN CTDKKPAAINW++GRGK+V+CEA +P  +V  VLKT+  A+ D+N +KNLVGSAMAGSIGG+NA AAN+VTA++IA GQDAAQNV SSNC+T ++  G   +DLY++CTMPSIE+GTVGGGT L  Q ACL +LGV+G    +PG NA+QLA +VC TV+AGELSLM+ALAAGHLV+SH+ HNRS + +  + G
Sbjct:    1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMN-----MFT-----GNNKICGWNYECPKFEEDVLSSDII---ILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQAKVSLGLDEDVSKRIEP---SVSLWQFYLSKMISMDIEQVITLSLAFLLAVKYIFFEQAETESTLSLKNPITSPVVTSKKAQ-----DNCCRREPLLVRRNQKLSSVEE---DPGANQERKVEVIKPLVVEAETTSRATFVLGASVASPPSALGTQEPG--------IELPIEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSTKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMTRGPVVRLPRACDSAEVKTWLETPEGFAVIKEAFDSTSRFARLQKLHVTMAGRNLYIRFQSRTGDAMGMNMISKGTEKALLKLQEFFPDMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQG 880

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|1325318518|ref|XP_023341016.1| (3-hydroxy-3-methylglutaryl-coenzyme A reductase-like [Eurytemora affinis])

HSP 1 Score: 947.192 bits (2447), Expect = 0.000e+0
Identity = 480/924 (51.95%), Postives = 620/924 (67.10%), Query Frame = 0

Query:   41 IRKIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDW--IETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQIINTLPGEDGQTPVVHRVKVVATALLMIAHIIFRPPFLFS---SASGISQPTTTLFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFN-------------RGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRH---------------------------GDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVA--KRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVV---GDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRS 914
            +RK+F++HGEFCASQPWEVIV T  FL+C+LTV  KH       D    S +     +  S V       W  +E ++M    CLA+LH  Y FKK+H + S+LI  I L Y+ F  +LY+LI++ +  P  DN+ ++WFLI L  D+ KVTR+ QFAL+SSH RRISEN+A GM  L P    + + K+ +VGL  LT   +LE    +A+++V V+FL +++FYP+GLSLV+ELM+  +GRP WDV+QII  LP E+ Q  VV+RV+V+A   L++ H   R P  +S   SA      ++        N E+  I  +++AL++KYLFYED +E   +RKTY+EEL RKF E SE E  +             R    EMDR SNSTDEGIS+ + ++ R  +   R                            G DS SES W E+ YL  + D E QT           D    E++    + Q+P+E   + EC KI   + DG   LIDEE++ LV+ K I  H LE +LNNPTRGVEIRRK + K    +R +  LP++++DY  VMGACCE+V+GYM +PVGV GPLNLDG   ++PMATTEGCLVAS NRGC AL+ CGV + I  DGMTRGP++R P++ +  E   W+E   NF  +K+NFDSTSRFARLQRL ++ AGR LYIRFVA +GDAMGMNM+SKA EFSL++++D+FP+ME++SLSGN CTDKKPAA+NW++GRGKSV+ EA VP  IV+TVLKTS +AL DLN SKNL+GS+MAGSIGGFNA AAN++TA++IATGQDAAQNV SSNC+T ++     G+DLY+TCTMPSIEVGTVGGGT+L AQGACL++LGV+G  PA PG NA QLA +VC  VLAGELSLMSALAAGHLV+SHLRHNRS
Sbjct:   27 VRKVFRNHGEFCASQPWEVIVATLTFLVCILTVWGKH------GDQPQPSNLNTTSSTQTSEV----GGSWTTMELVIMTFIRCLALLHCYYHFKKVHRVGSSLIMKITLAYLAFTMILYSLIVFGMMGPEFDNVKESWFLIMLFTDIPKVTRLAQFALTSSHQRRISENLAVGMAQLGPVMTFETVGKVLVVGLCGLTNYTRLELLCTFALITVFVDFLTFMSFYPSGLSLVIELMFNKNGRPHWDVKQIIKMLPHEETQNSVVYRVRVIAMTGLVVVHTFCRWPVDYSVEKSARTAQYISSEWLKLIVANAEQFCILALVLALAVKYLFYEDWEENCRIRKTYLEELERKFEEASESESVDTNTSERSTLRDCVRTGGDEMDRSSNSTDEGISLSTLSQRRMSANFDRRLSSNLDRRLSAGAKSLHSHRDRVSIVVGCDSFSESPWPEM-YLEAV-DAEVQTDSTVQPSQSYHDQTLEEEKDSLDYEQVPRE---VAECVKIMNSSEDGTSSLIDEEIIQLVDTKHIACHQLEKILNNPTRGVEIRRKIIGKAGNMRRAMNTLPYKHYDYQLVMGACCENVVGYMPVPVGVVGPLNLDGNPIHIPMATTEGCLVASTNRGCRALKDCGVNTAITYDGMTRGPVIRLPSMHRATEVMRWLENKSNFEVVKTNFDSTSRFARLQRLHIRIAGRLLYIRFVAKSGDAMGMNMLSKATEFSLRRMLDIFPDMEILSLSGNFCTDKKPAAVNWVEGRGKSVVAEAIVPAFIVKTVLKTSTSALVDLNISKNLIGSSMAGSIGGFNAHAANIITAIYIATGQDAAQNVGSSNCITLMEPWGRDGEDLYITCTMPSIEVGTVGGGTVLPAQGACLEMLGVRGPHPACPGENASQLARIVCGAVLAGELSLMSALAAGHLVRSHLRHNRS 935

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|821683432|gb|AKH60758.1| (3-hydroxy-3-methyl-glutaryl coenzyme A reductase [Dendroctonus armandi])

HSP 1 Score: 753.051 bits (1943), Expect = 0.000e+0
Identity = 403/894 (45.08%), Postives = 560/894 (62.64%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCV--PEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQIINTLPGEDGQTPVVHRVKVVATALLMIAHIIFRPPFL--------------FSSASGISQPTTTLFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEK---VAKRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQIDVV---GDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRS 914
            ++F+ HGEFC + PWEVIV T     C+LTV  +     T+        IK CL     C+   E+++ D I   V+     LAVL+  Y+F+K+H + S  I  IA  +  F+SL++  I+ ++      +L  A F   LL+D+ K   + QFAL+ ++      N+A G+  L PT  LD L +  ++G+G+++ + +LE  SW+A +SV+VN++V++TFYPA LSL+LEL   ++     D  +I+     +    PV+ RVK++ +  LM+ H+  R PF               F+       P  +   W     + ++I +++ AL IK +F+E  D   E++  +  E T K  +      F  G                           SC S +                   +D+E QT  + +S  +VD+  +          ++PK+ RSLE+C KI+K    G   L D+E++ L++ K I A+ +E  +++P RGV IRRK + +    + + + NLPFRN+DY  VMGACCE+VIGYM +PVG AGPL LDG+  Y+PMATTEGCLVAS NRGC AL+  GVTS ++ADGMTRGP+VRFP+I + ++A +W+++P+NF +IK  FDS+SRFARLQRL LK AGR L+IRF+A TGDAMGMNM+SK  E+SLK +  VF +ME++SLSGN CTDKKPAAINW++GRGKSV+CEA VP  ++ ++LKT+  AL D+N  KN+VGSA+AGSIGGFNA AAN+VTA+F+ATGQD AQNV+S NC+T ++     G+DLY++CTMPSIE+GT+GGGTIL AQ ACLD+LGVKG    +PGANA QLA +VC TVLAGELSLMSAL AGHLVKSHLRHNRS
Sbjct:    4 RLFRIHGEFCTNHPWEVIVATLTLTACMLTVEQQPPFRPTK------PTIKSCL----GCIQEAEYNAADLISMTVLRS---LAVLYCYYQFRKMHKLGSKYILGIAGVFTVFSSLVFTTIVLNLLRIKVSDLKDALFFFLLLIDLSKAAILAQFALNGANQAERKTNIAKGLAELGPTITLDTLVETLVIGVGTMSGVARLEMLSWFACLSVLVNYIVFMTFYPACLSLILELSQSSNFCKTKDSWKIL-AFKEDRKANPVLQRVKLIMSVGLMVVHVQSRWPFRDSEVYTIEPLVQQSFNKTDDSIAPHVSFIRWLVLGADHIVIIILVSALLIKLIFFEIKDNLVEVKPGFDRE-TPKPQKQMPMINFTLGE--------------------------SCESTY-------------------EDKEVQT--LTTSNSDVDNSSD---------EKVPKQCRSLEDCVKIFKNIDLGATELTDDEIILLIKNKNIAAYQIEKEVDDPERGVGIRRKILGRDLLESPKLLDNLPFRNYDYSLVMGACCENVIGYMPIPVGYAGPLLLDGRELYIPMATTEGCLVASTNRGCRALKDSGVTSSVVADGMTRGPVVRFPSIVRTSQAMQWIQDPDNFKKIKEQFDSSSRFARLQRLTLKIAGRFLFIRFIATTGDAMGMNMLSKGTEYSLKLVQQVFYDMEILSLSGNFCTDKKPAAINWIEGRGKSVVCEAIVPAKVISSILKTNVHALVDVNNPKNMVGSAVAGSIGGFNAHAANIVTAIFLATGQDPAQNVSSGNCMTLMEPWGPDGEDLYISCTMPSIEIGTIGGGTILPAQSACLDILGVKGSNIENPGANACQLAKIVCGTVLAGELSLMSALTAGHLVKSHLRHNRS 826

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|936704634|ref|XP_014230286.1| (3-hydroxy-3-methylglutaryl-coenzyme A reductase [Trichogramma pretiosum] >gi|936704636|ref|XP_014230287.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Trichogramma pretiosum] >gi|936704638|ref|XP_014230288.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Trichogramma pretiosum] >gi|936704640|ref|XP_014230290.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Trichogramma pretiosum])

HSP 1 Score: 749.584 bits (1934), Expect = 0.000e+0
Identity = 416/940 (44.26%), Postives = 577/940 (61.38%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTV----GSKHVMM-VTEMDSSASSKIKPCLPSDPSCVPEHHSRDW-----------IETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQIINTLPGEDGQ-TPVVHRVKVVATALLMIAHIIFRPPFLFSSAS-------------GI----------SQPTTTLF--SWATTNIEKVLITVVIVALSIKYLFYEDMDE-AQELRKTYIEELTRKFAEDSEQE----EFNRGNKVEMDRVSN-------STDEGISIGSSAKPRPPS-----CASRHGDDSSSESAWSEVGYLPD--LKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAKRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAV 918
            ++F++HG FCA  P EVIVTTF    C+L +    GSK      T   S+ S+      P+  +      +  W            + ++M    CLA+L   ++F+ +  + S  I  IA  +  F+S+++ L + + G     +L  A F   L++D+ K   + Q AL+S     +  N+A GM +L P+  LD L +I L+G+GSL+ + +LE    YA + V+VN++V++TFYPA LSLVLEL   ++ +       ++N    ED +  PVV R+K++  A L + H   R PF    A              GI          S P    F  +W + + + ++I +++VAL+IK++F+ED  E A++LR    +    +  +D E++    E +  +  EMDR++        +T    + GSS +  P S       +  G+D      W EVG   D  L D+E QT      +           +        P  PRS++EC  IY+  + G   L D EV+ LV  K I+++ LE  + +  RGV IRR  + +       +LP+RN+DY  V+G+CCE+VIGY+ +P G+AGPL +DG+LF+VPMATTEGCLVAS NRG  AL  CGVTSR++ADGMTRGP+VRFPN+ + +EA  WM++PENF ++KS+FD TSRFARL ++ ++ AGR L++RFVA TGDAMGMNM+SK  E SL Q+  +FP+ME++SLSGN CTDKKPAA+NW++GRGKSV+CEA VPG IV +VLKTS  AL D+N SKN++GSA+AGSIGGFNA AAN+VTA+FIATGQD AQNV SSNC+T ++     G+DLY++CTMPSIE+GTVGGGT L AQGACL +LGVKG     PG NA +LA +VCATVLAGELSLM+AL AGHLVKSHLRHNRS+  V
Sbjct:    4 RMFEAHGRFCAGHPLEVIVTTFTLTACMLNMETINGSKQAAGGATGPTSAGSTTAAGGSPTTAASAASAGTNCWHGRCGSEELNPADVILMTVIRCLAILFSYHQFRNLQNLGSKYILGIAGLFTMFSSIIFTLSVLNFGRSDISDLKDALFFFLLVIDLNKAAILAQLALNSKRQDEVRANIARGMSLLGPSVTLDTLVEILLIGIGSLSGVKRLEILCGYACLGVVVNYVVFMTFYPACLSLVLELSRSSNDKIIMSHGSLLNE---EDQKPNPVVERLKLIMIAGLFVVHAHSRWPFRTDDAEEAIDEQVASSVNPGILLTTNRNKTESPPDYRGFFMNWLSVSADNIVILILLVALAIKFIFFEDRGEIARQLRLEEEQRDEEESKQDDEEKKQEKEQDSNSSEEMDRLTRRFAGAMATTLTATTAGSSHRTGPSSKVFAGLVAAPGED------WIEVGAEADVELVDKEVQTEQQQQQQVATITSSGTVSKSNDDAATSP--PRSVDECLAIYRSEL-GASVLTDAEVIQLVRAKYIQSYQLEKAVGDMERGVGIRRTLLNEAEVCITADLPYRNYDYSKVLGSCCENVIGYVPVPCGIAGPLLVDGELFHVPMATTEGCLVASTNRGSRALMGCGVTSRVVADGMTRGPVVRFPNVVRASEAMAWMQQPENFEKMKSSFDETSRFARLTKIHVRIAGRHLFVRFVARTGDAMGMNMLSKGTEKSLLQVQRLFPDMEILSLSGNFCTDKKPAAVNWIEGRGKSVVCEAVVPGDIVSSVLKTSTQALVDVNMSKNMIGSAVAGSIGGFNAHAANIVTAIFIATGQDPAQNVGSSNCMTLMEPWGPTGEDLYVSCTMPSIEIGTVGGGTGLPAQGACLQMLGVKGANMEHPGQNADKLARIVCATVLAGELSLMAALTAGHLVKSHLRHNRSSTTV 931

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|133722002|gb|ABO37160.1| (3-hydroxy-3-methylglutaryl-CoA reductase [Phaedon cochleariae])

HSP 1 Score: 747.273 bits (1928), Expect = 0.000e+0
Identity = 413/927 (44.55%), Postives = 574/927 (61.92%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTD--GRPRWDVRQIINTLPGEDGQT-PVVHRVKVVATALLMIAHIIFRPPFLFSSASGISQPTTT----------------LFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDD---SSSESAWSEVGYLPDLKDQEAQTT-----DMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVA--KRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAGPESM-AKPMLCIHP 936
            + F++HGEFCAS PWEVIV T     C+LTV  +H           +   KP L     C+ E  + +  + +VM    CLAVL+  Y+F K+  + S  I  IA  +  F+S ++   + +I      +L  A F   LL+D+ K   + QFAL++S    +  N+A GM VL PT  LD + +  ++G+G+L+ + +LE  S +A +SV+VN++V++TFYPA LSL+LEL   T+  G+ +  + +       ED ++ PVV RVK++ +A LM+ H+  R PF    +  +                      +  W   + + ++I ++++AL IK++F+E+ +E  E+ K  + E   K        +FN+ N+    R               KP P     +H D      S+   S+     +L+D+  QTT        S   ++DD                +  RSL+EC  IY  +  G  +L D+EV+ LV  + I A+ +E  + NP RGV IRRK +  +   K+ + +LP+RN+DY  VMGACCE+VIGYM +PVG AGPL LDG+  YVPMATTEGCLVAS NRGC AL+T GV S I+ADGMTRGP+VRFP++ + + A +WME PENF ++K+ FDSTSRFARL +L ++ AGR L+IRFVA TGDAMGMNM+SK  E +LK + +VFP+ME++SLSGN CTDKKPAA+NW++GRGKSV+CEA VP  IV +VLKT+  AL D+N SKN++GSA+AGSIGGFNA A N+VTA+FIATGQD AQN+ SS+C+T ++     G+DLY++CTMPSIE+GTVGGGT+L AQ +CL++LGV+G     PG NA QLA +VC  VLAGELSLM+ALAAGHLV+SHLRHNRS   +      ES+ AK   C+ P
Sbjct:    4 RFFRAHGEFCASHPWEVIVATLTLTACMLTVDQQH----------PAPPPKPTLRFCAGCLNEAEN-NAADVIVMTTIRCLAVLYCYYQFCKLQKLGSKYILGIAGLFTVFSSFIFTSTVLNILRINMADLKDALFFFLLLIDLSKAAMLAQFALNASCQTEVKNNIAKGMSVLGPTITLDTIVETLVIGVGTLSGVHRLEMLSCFACLSVLVNYIVFMTFYPACLSLILELSRTTNIYGKKQSIISKAFKE---EDHKSNPVVQRVKLIMSAGLMLVHVHSRWPFKQEDSDDVGSLVVEQHMTHNRTEETALHGYIMKWVALSADHIVILILLLALVIKFIFFENKEEFAEIIKASMSENLDK------SNDFNKLNREMQHR--------------PKPEPEMPIFKHSDTFFFGKSDDEKSDKSSDVELEDKAVQTTRSDFVKEGSPSSDLDDS---------------RPCRSLDECLSIYNNSDLGAGFLTDDEVILLVRHRRIAAYQIEKAVENPERGVGIRRKILGGLGNFKKALSDLPYRNYDYAKVMGACCENVIGYMPVPVGYAGPLLLDGRELYVPMATTEGCLVASTNRGCRALKTVGVASSIVADGMTRGPVVRFPSLVEASAALKWMETPENFAKMKAEFDSTSRFARLSKLLIRIAGRYLFIRFVAKTGDAMGMNMLSKGTEIALKHVQNVFPDMEILSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIVPSQIVTSVLKTTVQALVDVNYSKNMIGSAVAGSIGGFNAHAGNIVTAIFIATGQDPAQNIGSSHCMTLMEPWGKAGEDLYISCTMPSIEIGTVGGGTVLPAQASCLEMLGVRGANIECPGENANQLARIVCGLVLAGELSLMAALAAGHLVRSHLRHNRSTTVLPEGVSFESLVAKKDSCLSP 881

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|1133421505|ref|XP_019866380.1| (PREDICTED: LOW QUALITY PROTEIN: 3-hydroxy-3-methylglutaryl-coenzyme A reductase-like [Aethina tumida])

HSP 1 Score: 745.347 bits (1923), Expect = 0.000e+0
Identity = 410/903 (45.40%), Postives = 566/903 (62.68%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQ-IINTLPGEDGQTPVVHRVKVVATALLMIAHIIFRPPFLFSSASGI--------SQPTTT-------LFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKP--RPPSC---ASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKY--VEKVAKRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQL-IDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAV 918
            +IF++HGEFCA+ PWEVIV T     C+ T+  +          S S   KP       C+ E    +  + +VM    CLAVL+  Y+F+ +H + S  I  IA  +  F+S ++   + +I       L  A F   LL+D+ K   + QFAL++S+   +  N+A GM +L PT  LD + +  ++G+G+L+ + +LE  S +A +SV+VN++V++TFYPA LSL+LEL   T+    +D +   I+    ED   PVV RVK++ +A LM+ H   R PF    +  I        +Q  T        +  W T + + ++I ++++AL +K++F+E+       ++  +++L                 +  M   SN   +  S  ++  P  +PP     + +   D S +  +         +D+E QT     S+ E    E+    ++          R++EEC KI+  +  G + L DEEV+ LV  K I  + +E  + +P RGV IRRK   V+    R + +LP++N+DY  VMGACCE+VIGYM +PVG AGPLNLDG+ F+VPMATTEGCLVAS NRGC AL   G+TSRI+ DGMTRGP+VRFP++A+ + AK+WME+P NFL +K NFD TSRFARL ++ +K AGR L+IRF A TGDAMGMNM+SK  E SLK +  D +P+ME++SLSGN CTDKK AAINW++GRGKSV+CEA VP   V +VLKTS  AL D+N +KN++GSAMAGSIGGFNA AANVVTA++IATGQD AQN+ASSNC+T ++     G+DLYMTCTMPSIE+GTVGGGT+L AQ ACL++LGVKG  P +PG NA QLA ++CATVLAGELSLM+AL AGHLVKSHLRHNRS   +
Sbjct:    4 RIFRAHGEFCATHPWEVIVATLTLTACMFTMDQQ----------STSPPPKPTFRYCAGCIHEAE-YNAADVIVMTLIRCLAVLYSYYQFRNLHKLGSKYILGIAGLFTVFSSFVFTTTVLNILRIDVTELKDALFFFLLLIDLSKAAVLAQFALNASNQEEVRSNIARGMSLLGPTITLDTIVETLVIGVGTLSGVHRLETLSCFACLSVLVNYIVFMTFYPACLSLILELSRTTN---LYDKKHSFISAFKEEDKSNPVVQRVKLIMSAGLMLVHAHSRWPFKEVDSDNIGSLVDQHMTQNRTEDTALHGYIMKWVTLSADHIVILILLLALVVKFIFFEN-------KEDLVDQL-----------------RASMTETSNVPRKYRSKYNTNMPFLKPPHTFFLSKKQISDISDDVVF---------EDKEVQTHSRCESDVESSSPEDDTALKV---------CRNIEECLKIFXNSEVGAKELTDEEVILLVRNKHITNYQIEKAVEDPERGVSIRRKILGVDGNCMRALTDLPYKNYDYGKVMGACCENVIGYMPVPVGFAGPLNLDGKQFFVPMATTEGCLVASTNRGCRALLASGITSRIVGDGMTRGPVVRFPSLARASAAKKWMEDPANFLLMKENFDDTSRFARLTKIFVKIAGRHLFIRFEATTGDAMGMNMLSKGTEKSLKFVKKDFYPDMEILSLSGNFCTDKKAAAINWIEGRGKSVVCEAVVPAKTVTSVLKTSVHALVDVNTTKNMIGSAMAGSIGGFNAHAANVVTAIYIATGQDPAQNIASSNCMTLMEPWGENGEDLYMTCTMPSIEIGTVGGGTVLPAQAACLEMLGVKGPHPETPGENASQLARIICATVLAGELSLMAALTAGHLVKSHLRHNRSTTTI 850

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|1285022143|ref|XP_023023291.1| (3-hydroxy-3-methylglutaryl-coenzyme A reductase-like isoform X1 [Leptinotarsa decemlineata])

HSP 1 Score: 744.191 bits (1920), Expect = 0.000e+0
Identity = 417/896 (46.54%), Postives = 560/896 (62.50%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQII--NTLPGEDGQT-PVVHRVKVVATALLMIAHIIFRPPFLFSSASG-----ISQPTTT-----------LFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYV--EKVAKRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRS 914
            + F +HGEFCAS PWEVIV T     C+LTV  +H           +   KP +     C+ E    +  + +VM    CLAVL+  Y F K+H + S  I +IA  +  F+S ++   + +I      +L  A F   LL+D+ K   + QFAL++S    +  N+A GM VL PT  LD + +  ++G+G+L+ + +LE  S +A +SV+VN++V++TFYPA LSL+LEL   T    +   +Q I       ED ++ PVV RVKV+ +A LM+ H   R PF    +       + Q  T            +  W T + + ++I ++++AL +K++F+E+ +E  E  +    E   K + +S     N  +K   +       E   +G S             D+ S +S+ SEV    +L+D+  QT+    +E  +  + N E         +    R+LEEC  IY     G   L DEEV+ LV+ K I  + LE  L+NP RGV+IRRK V  E  + + +  LPFRN+DY  VMGACCE+VIGYM +PVG AGPL LDG+  YVPMATTEGCLVAS NRGC AL+  GV S I+ DGMTRGP+VRFP+I+K + A +WME P NF  +K  FD++SRFARL R+ ++ AGR L+IRFVA TGDAMGMNM+SK  E SLK +   FP+ME++SLSGN CTDKKPAA+NW++GRGKSV+CEA +   IV ++LKT+  AL D+N SKN++GSAMAGSIGGFNA AAN+VTA+FIATGQD AQNV SSNC+T ++     G+DLYM+CTMPSIE+GTVGGGT+L AQ ACL++LGVKG    +PG NA QLA +VC  VLAGELSLM+ALAAGHLVKSHLRHNRS
Sbjct:    4 RFFHAHGEFCASHPWEVIVATITLTACMLTVDQQH----------PAPPPKPVIRFCTGCLHEAE-YNAADVIVMTIIRCLAVLYCYYHFCKLHKLGSKYILSIAGLFTVFSSFIFTTTVLNILRMNVTDLKDALFFFLLLIDLSKAAMLAQFALNASSKTEVKNNIAKGMSVLGPTITLDTVVETLVIGVGTLSGVHRLEMLSCFACLSVLVNYVVFMTFYPACLSLILELSRATSIYAK---KQCILSKAFREEDHKSNPVVQRVKVIMSAGLMLVHAHSRWPFREGDSDDAGSLIVDQHMTLNRTEDTALHGYIMKWVTLSADHIVILILLLALVVKFIFFENREEFTEKIRASTSESLEKNSSESFSINQNLNDKFPPEIPVYKPSEKFFLGKSDI-----------DEKSDKSSVSEV----ELEDKAIQTSRYDLNEQNLLSENNEE--------NVKNSCRTLEECLAIYNDFDLGAVALNDEEVILLVKHKHIATYQLEKALDNPERGVKIRRKIVGNEANSLKALTGLPFRNYDYSKVMGACCENVIGYMPVPVGYAGPLLLDGRELYVPMATTEGCLVASTNRGCRALKQSGVISSIVGDGMTRGPVVRFPSISKASAAMKWMESPSNFALMKEKFDASSRFARLTRILIRIAGRYLFIRFVAKTGDAMGMNMLSKGTELSLKFVQQEFPDMEIMSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIISAKIVTSILKTNVHALVDVNYSKNMIGSAMAGSIGGFNAHAANIVTAIFIATGQDPAQNVGSSNCMTLMEPWGESGEDLYMSCTMPSIEIGTVGGGTVLPAQAACLEMLGVKGANHDNPGENANQLARIVCGMVLAGELSLMAALAAGHLVKSHLRHNRS 862

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|859132811|gb|AKO63319.1| (3-hydroxy-3-methylglutaryl coenzyme A reductase 2 [Leptinotarsa decemlineata])

HSP 1 Score: 741.495 bits (1913), Expect = 0.000e+0
Identity = 415/896 (46.32%), Postives = 558/896 (62.28%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQII--NTLPGEDGQT-PVVHRVKVVATALLMIAHIIFRPPFLFSSASG-----ISQPTTT-----------LFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAK--RDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRS 914
            + F +HGEFCAS PWEVIV T     C+LTV  +H           +   KP +     C+ E    +  + +VM    CLAVL+  Y F K+H + S  I ++A  +  F+S ++   + +I      +L  A F   LL+D+ K   + QFAL++S    +  N+A GM VL PT  LD + +  ++G+G+L+ + +LE  S +A +SV+VN++V++TFYPA LSL+LEL   T    +   +Q I       ED ++ PVV RVKV+ +A LM+ H   R PF    +       + Q  T            +  W T + + ++I ++++AL +K++F+E+ +E  E  +    E   K + +S     N  +K   +       E   +G S             D+ S +S+ SEV    +L+D+  QT+    +E  +  + N E         +    R+LEEC  IY     G   L DEEV+ LV+ K I  + LE  L+NP RGV+IRRK V   A   + +  LPFRN+DY  VMGACCE+VIGYM +PVG AGPL LDG+  YVPMATTEGCLVAS NRGC  L+  GV S I+ DGMTRGP+VRFP+I+K + A +WME P NF  +K  FD++SRFARL R+ ++ AGR L+IRFVA TGDAMGMNM+SK  E SLK +   FP+ME++SLSGN CTDKKPAA+NW++GRGKSV+CEA +   IV ++LKT+  AL D+N SKN++GSAMAGSIGGFNA AAN+VTA+FIATGQD AQNV SSNC+T ++     G+DLYM+CTMPSIE+GTVGGGT+L AQ ACL++LGVKG    +PG NA QLA +VC  VLAGELSLM+ALAAGHLVKSHLRHNRS
Sbjct:    4 RFFYAHGEFCASHPWEVIVATITLTACMLTVDQQH----------PAPPPKPVIRFCTGCLHEAE-YNAADVIVMTIIRCLAVLYCYYHFCKLHKLGSKYILSVAGLFTVFSSFIFTTTVLNILRMNVTDLKDALFFFLLLIDLSKAAMLAQFALNASSKTEVKNNIAKGMSVLGPTITLDTVVETLVIGVGTLSGVHRLEMLSCFACLSVLVNYVVFMTFYPACLSLILELSRATSIYAK---KQCILSKAFREEDHKSNPVVQRVKVIMSAGLMLVHAHSRWPFREGDSDDAGSLIVDQHMTLNRTEDTALHGYIMKWVTLSADHIVILILLLALVVKFIFFENREEFTEKIRASTSESLEKNSSESFCINQNLNDKFPPEIPVYKPSEKFFLGKSDI-----------DEKSDKSSVSEV----ELEDKAIQTSRYDLNEQNLLSENNEE--------NVKNSCRTLEECLAIYNDFDLGAVALNDEEVILLVKHKHIATYQLEKALDNPERGVKIRRKIVSNEANSLKALTGLPFRNYDYSKVMGACCENVIGYMPVPVGYAGPLLLDGRELYVPMATTEGCLVASTNRGCRTLKQSGVISSIVGDGMTRGPVVRFPSISKASAAMKWMESPSNFALMKEKFDASSRFARLTRILIRIAGRYLFIRFVAKTGDAMGMNMLSKGTELSLKFVQQEFPDMEIMSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIISAKIVTSILKTNVHALVDVNYSKNMIGSAMAGSIGGFNAHAANIVTAIFIATGQDPAQNVGSSNCMTLMEPWGESGEDLYMSCTMPSIEIGTVGGGTVLPAQAACLEMLGVKGANHDNPGENANQLARIVCGMVLAGELSLMAALAAGHLVKSHLRHNRS 862

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|1285022145|ref|XP_023023292.1| (3-hydroxy-3-methylglutaryl-coenzyme A reductase-like isoform X2 [Leptinotarsa decemlineata])

HSP 1 Score: 739.569 bits (1908), Expect = 0.000e+0
Identity = 417/896 (46.54%), Postives = 559/896 (62.39%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCVPEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQII--NTLPGEDGQT-PVVHRVKVVATALLMIAHIIFRPPFLFSSASG-----ISQPTTT-----------LFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYV--EKVAKRDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRS 914
            + F +HGEFCAS PWEVIV T     C+LTV  +H           +   KP +     C+ E    +  + +VM    CLAVL+  Y F K+H + S  I +IA  +  F+S ++   + +I      +L  A F   LL+D+ K   + QFAL++S    +  N+A GM VL PT  LD + +  ++G+G+L+ + +LE  S +A +SV+VN++V++TFYPA LSL+LEL   T    +   +Q I       ED ++ PVV RVKV+ +A LM+ H   R PF    +       + Q  T            +  W T + + ++I ++++AL +K++F+E+ +E  E  +    E   K + +S     N  +K   +       E   +G S             D+ S +S  SEV    +L+D+  QT+    +E  +  + N E         +    R+LEEC  IY     G   L DEEV+ LV+ K I  + LE  L+NP RGV+IRRK V  E  + + +  LPFRN+DY  VMGACCE+VIGYM +PVG AGPL LDG+  YVPMATTEGCLVAS NRGC AL+  GV S I+ DGMTRGP+VRFP+I+K + A +WME P NF  +K  FD++SRFARL R+ ++ AGR L+IRFVA TGDAMGMNM+SK  E SLK +   FP+ME++SLSGN CTDKKPAA+NW++GRGKSV+CEA +   IV ++LKT+  AL D+N SKN++GSAMAGSIGGFNA AAN+VTA+FIATGQD AQNV SSNC+T ++     G+DLYM+CTMPSIE+GTVGGGT+L AQ ACL++LGVKG    +PG NA QLA +VC  VLAGELSLM+ALAAGHLVKSHLRHNRS
Sbjct:    4 RFFHAHGEFCASHPWEVIVATITLTACMLTVDQQH----------PAPPPKPVIRFCTGCLHEAE-YNAADVIVMTIIRCLAVLYCYYHFCKLHKLGSKYILSIAGLFTVFSSFIFTTTVLNILRMNVTDLKDALFFFLLLIDLSKAAMLAQFALNASSKTEVKNNIAKGMSVLGPTITLDTVVETLVIGVGTLSGVHRLEMLSCFACLSVLVNYVVFMTFYPACLSLILELSRATSIYAK---KQCILSKAFREEDHKSNPVVQRVKVIMSAGLMLVHAHSRWPFREGDSDDAGSLIVDQHMTLNRTEDTALHGYIMKWVTLSADHIVILILLLALVVKFIFFENREEFTEKIRASTSESLEKNSSESFSINQNLNDKFPPEIPVYKPSEKFFLGKSDI-----------DEKSDKS--SEV----ELEDKAIQTSRYDLNEQNLLSENNEE--------NVKNSCRTLEECLAIYNDFDLGAVALNDEEVILLVKHKHIATYQLEKALDNPERGVKIRRKIVGNEANSLKALTGLPFRNYDYSKVMGACCENVIGYMPVPVGYAGPLLLDGRELYVPMATTEGCLVASTNRGCRALKQSGVISSIVGDGMTRGPVVRFPSISKASAAMKWMESPSNFALMKEKFDASSRFARLTRILIRIAGRYLFIRFVAKTGDAMGMNMLSKGTELSLKFVQQEFPDMEIMSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIISAKIVTSILKTNVHALVDVNYSKNMIGSAMAGSIGGFNAHAANIVTAIFIATGQDPAQNVGSSNCMTLMEPWGESGEDLYMSCTMPSIEIGTVGGGTVLPAQAACLEMLGVKGANHDNPGENANQLARIVCGMVLAGELSLMAALAAGHLVKSHLRHNRS 860

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|91082547|ref|XP_973850.1| (PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Tribolium castaneum] >gi|642922803|ref|XP_008193331.1| PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Tribolium castaneum] >gi|1004400206|gb|KYB27676.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase-like Protein [Tribolium castaneum])

HSP 1 Score: 735.717 bits (1898), Expect = 0.000e+0
Identity = 414/920 (45.00%), Postives = 570/920 (61.96%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPSCV--PEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCTDGRPRWDVRQ--IINTLPGEDGQT-PVVHRVKVVATALLMIAHIIFRPPFLFSSASGI-------------SQPTTT---LFSWATTNIEKVLITVVIVALSIKYLFYEDMDEAQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAK--RDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRSNLAVGSVAGPESMAKPMLCIHP 936
            ++F++HGEFCA+ PWEVIV T     C+LTV  +H           +   KP L     C+   E+++ D I   VM    CLAVL+  Y+F  +  + S  I  IA  +  F+S ++   + ++      +L  A F   LL+D+ K   + Q ALS+S+   +  N+A GM VL PT  LD + +  ++G+G+L+ + +LE  S++A +SV+VN++V++TFYPA LSL+LEL   T+    +  +Q  I   L  ED ++ PVV RVK++ +A LM+ H   R PF       I             ++ TT    +  W T + + ++I ++++AL +K++F+E+ +E  E  + +I             E  + G K    ++     +   + ++ K           +DS+ E             D+E QT D+   E E +    G    +       K  RSLEEC KIY  +  G   L D+EV+ LV+ K I A+ +E  +++P RGV IRRK + +       + +LPFRN+DY  VMGACCE+VIGYM +PVG AGPLNLDG+  YVPMATTEGCLVAS NRGC AL  CGVTSR+++DGMTRGP+VRFP+I K +EA  WM+  +NF  +K  FDS+SRFARL +L +K AGR L++RF A TGDAMGMNM+SK  E SLK +   FPEME++SLSGN CTDKKPAA+NW++GRGKSV+CEA +P  IV+ VLKTS  AL D+N SKN++GSA+AGSIGGFNA AAN+VTA++IATGQD AQN+ SSNC+T ++     G+DLY++CTMPSIE+GTVGGGT+L AQ +CL++L VKG  P  PG NA QLA +VC TVLAGELSLM+AL AGHLV+SHLRHNRS   +     PE  ++    I P
Sbjct:    4 RLFRAHGEFCATHPWEVIVATLTLAACMLTVDQQH----------PAPPPKPTLRYCAECLQEAEYNAADLI---VMTLIRCLAVLYCYYQFCNLEKLGSKYILGIAGLFTVFSSFVFTSTVLNLLWIDVSDLKDALFFFLLLIDLSKAAMLAQSALSASNQEEVKSNIARGMAVLGPTITLDTIVETLVIGVGTLSGVHRLEMLSYFACLSVLVNYIVFMTFYPACLSLILELSRTTN---IYGNKQSLIARALKEEDHKSNPVVQRVKLIMSAGLMLVHARSRWPFKEDDVENIRPLVVEQHMTLNRTEDTTLHEYIMKWVTVSADHIVILILLLALVVKFVFFENKEELAEQLRAHIS-----------TESVDPGKKDNRFKMPLIKTQSFFLTNNTK-----------EDSACE-------------DKEVQT-DIGRLESEFEKLPAGNDVSV-------KTCRSLEECLKIYNDSNLGGAALSDDEVILLVKNKHIPAYQIEKAVDDPERGVGIRRKILAREGNFSEALTDLPFRNYDYAKVMGACCENVIGYMPVPVGYAGPLNLDGRHVYVPMATTEGCLVASTNRGCRALLDCGVTSRVVSDGMTRGPVVRFPSITKASEAMSWMKCSQNFEAMKQQFDSSSRFARLSKLLIKIAGRHLFVRFEAKTGDAMGMNMVSKGTEMSLKYVQKQFPEMEILSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIIPSEIVKKVLKTSTPALVDVNNSKNMIGSAVAGSIGGFNAHAANIVTAIYIATGQDPAQNIGSSNCMTLMEPWGETGEDLYVSCTMPSIEIGTVGGGTVLPAQSSCLEMLRVKGSHPDCPGENASQLARIVCGTVLAGELSLMAALTAGHLVRSHLRHNRSTTTI-----PEEFSQNRYHIPP 859

[Close]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Match: gi|1080036668|ref|XP_018578730.1| (3-hydroxy-3-methylglutaryl-coenzyme A reductase [Anoplophora glabripennis])

HSP 1 Score: 733.406 bits (1892), Expect = 0.000e+0
Identity = 420/905 (46.41%), Postives = 571/905 (63.09%), Query Frame = 0

Query:   43 KIFKSHGEFCASQPWEVIVTTFIFLICVLTVGSKHVMMVTEMDSSASSKIKPCLPSDPS---CV-----PEHHSRDWIETLVMAGFYCLAVLHITYRFKKIHLIRSNLIFNIALCYMTFASLLYALIIWSIGNPLKDNLHQAWFLIFLLVDMQKVTRMGQFALSSSHHRRISENVANGMYVLAPTFALDCLAKIFLVGLGSLTRIPQLEAFSWYAVVSVMVNFLVYLTFYPAGLSLVLELMYCT--DGRPRWDVRQIINTLPGEDGQT-PVVHRVKVVATALLMIAHIIFRPPFLFSSASGIS-----QPTTT-----------LFSWATTNIEKVLITVVIVALSIKYLFYEDMDE-AQELRKTYIEELTRKFAEDSEQEEFNRGNKVEMDRVSNSTDEGISIGSSAKPRPPSCASRHGDDSSSESAWSEVGYLPDLKDQEAQTTDMASSEDEVDDDENGEKRRIRHHHQLPKEPRSLEECTKIYKGTMDGVEYLIDEEVVHLVEKKVIRAHALESVLNNPTRGVEIRRKYVEKVAK--RDIGNLPFRNFDYDTVMGACCESVIGYMTMPVGVAGPLNLDGQLFYVPMATTEGCLVASVNRGCSALRTCGVTSRILADGMTRGPIVRFPNIAKMAEAKEWMEEPENFLQIKSNFDSTSRFARLQRLKLKPAGRELYIRFVAYTGDAMGMNMISKAAEFSLKQLIDVFPEMELVSLSGNMCTDKKPAAINWLDGRGKSVICEATVPGHIVETVLKTSPAALADLNRSKNLVGSAMAGSIGGFNAQAANVVTAVFIATGQDAAQNVASSNCLTQID---VVGDDLYMTCTMPSIEVGTVGGGTILTAQGACLDLLGVKGCQPASPGANAKQLASVVCATVLAGELSLMSALAAGHLVKSHLRHNRS 914
            +IF++HGEFCAS PWEVIV T     C+LTV  +H                P  P  P+   CV      E+++ D I   VM    CLAVL+  Y+F K+  + S  I  IA  +  F+S ++   + +I      +L  A F   LL+D+ K   + QFAL++S    +  N+A GM +L PT  LD + +  ++G+G+L+ + +LE  S++A +SV+VN++V++TFYPA LSL+LEL   T   G+       I  T   ED ++ PVV RVK++ +A LM+ H   R PF       IS     Q  T            +  W T + + ++I ++++AL IK++F+E+ ++ A+++R +  E L      D E  EF + N+     + N     +      KP       ++  D +SE          + +D+E QTT   S         +G+    R   ++    RSL+EC +IY  +  G   L DEEV+ LV+ K I A+ +E  +++P RGV IRRK +       R + +LP++N+DY  VMGACCE+VIGYM +PVG AGPL LDG+  +VPMATTEGCLVAS NRGC AL+ CGVTS I+ DGMTRGP+VRFP++ K + A +WME P NF  IK  FDS+SRFARL R+ ++ AGR L+IRFVA TGDAMGMNM+SK  E SLK +   FP+ME++SLSGN CTDKKPAA+NW++GRGKSV+CEA VPG +V TVLKT+  AL D+N SKN++GSA+AGSIGGFNA AAN+VTA+FIATGQD AQN+ SSNC+T ++    +G+DLY++CTMPSIE+GT+GGGT+L AQ ACL++LGVKG    +PG NA QLA +VC  VLAGELSLM+ALAAGHLVKSHLRHNRS
Sbjct:    4 RIFRAHGEFCASHPWEVIVATLTLTACMLTVDQQH----------------PAPPPKPAVRYCVGCLNEAEYNAADVI---VMTIIRCLAVLYCYYQFCKLQKLGSKYILGIAGLFTVFSSFIFTTTVLNILRIDVADLKDALFFFLLLIDLSKAAMLAQFALNASSQTEVKSNIAKGMSLLGPTITLDTIVETLVIGVGTLSGVHRLEMLSYFACLSVLVNYVVFMTFYPACLSLILELSRTTIIYGKKH---SLITKTFKEEDHKSNPVVQRVKLIMSAGLMLVHAHSRWPFRQEDVDNISPLVAEQHMTLNRTEETALHGYIMKWVTLSADHIVILILLLALVIKFIFFENKEDFAEQIRASLSESL------DKESSEFIQLNQ----ELRNKFPPAMPF---FKPAEKFFLGKNISDDTSEV---------EFEDKEVQTTKYES---------DGDSSASRDEQEIC---RSLQECLEIYNDSDLGAVALTDEEVILLVKNKHIAAYQIEKAVDDPVRGVGIRRKILGSDGNFTRALADLPYKNYDYGKVMGACCENVIGYMPVPVGYAGPLLLDGRELFVPMATTEGCLVASTNRGCRALKNCGVTSSIVGDGMTRGPVVRFPSLVKASAALKWMEIPANFELIKEKFDSSSRFARLTRILIRIAGRYLFIRFVAKTGDAMGMNMLSKGTELSLKFVQTKFPDMEILSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIVPGKVVTTVLKTTVHALVDVNYSKNMIGSAIAGSIGGFNAHAANIVTAIFIATGQDPAQNIGSSNCMTLMEPWGEIGEDLYISCTMPSIEIGTIGGGTVLPAQAACLEMLGVKGSHIENPGENASQLARIVCGMVLAGELSLMAALAAGHLVKSHLRHNRS 852

The following BLAST results are available for this feature:

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. L. salmonis genes
BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. L. salmonis genes
Analysis Date: 2018-04-19 (T. kinsejongensis vs L. Salmonis peptides)
Total hits: 1


Match Name	E-value	Identity	Description
EMLSAG00000004979	0.000e+0	46.67	supercontig:LSalAtl2s:LSalAtl2s260:1508384:1510927...	[more]

BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. SwissProt
Analysis Date: 2018-04-19 (T. kingejongensis peptided Blastp vs. SwissProt)
Total hits: 25


Match Name	E-value	Identity	Description
gi\|391359371\|sp\|A7Z064.2\|HMDH_BOVIN	0.000e+0	41.35	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|2495262\|sp\|Q29512.1\|HMDH_RABIT	0.000e+0	42.36	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|118573790\|sp\|Q1W675.1\|HMDH_PIG	0.000e+0	41.41	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|123343\|sp\|P04035.1\|HMDH_HUMAN	0.000e+0	42.11	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|123344\|sp\|P09610.1\|HMDH_MESAU	0.000e+0	41.48	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|123347\|sp\|P20715.1\|HMDH_XENLA	0.000e+0	41.55	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|118573791\|sp\|P51639.2\|HMDH_RAT	0.000e+0	41.80	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|83305798\|sp\|Q5R6N3.1\|HMDH_PONAB	0.000e+0	42.00	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|123341\|sp\|P00347.1\|HMDH_CRIGR	0.000e+0	41.85	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]
gi\|408360266\|sp\|Q01237.3\|HMDH_MOUSE	0.000e+0	42.00	RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme ...	[more]

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BLAST of 3-hydroxy-3-methylglutaryl- reductase vs. nr
Analysis Date: 2018-05-15 (T. kingsejongensis proteins Blastp vs. NR)
Total hits: 25


Match Name	E-value	Identity	Description
gi\|1325318518\|ref\|XP_023341016.1\|	0.000e+0	51.95	3-hydroxy-3-methylglutaryl-coenzyme A reductase-li...	[more]
gi\|821683432\|gb\|AKH60758.1\|	0.000e+0	45.08	3-hydroxy-3-methyl-glutaryl coenzyme A reductase [...	[more]
gi\|936704634\|ref\|XP_014230286.1\|	0.000e+0	44.26	3-hydroxy-3-methylglutaryl-coenzyme A reductase [T...	[more]
gi\|133722002\|gb\|ABO37160.1\|	0.000e+0	44.55	3-hydroxy-3-methylglutaryl-CoA reductase [Phaedon ...	[more]
gi\|1133421505\|ref\|XP_019866380.1\|	0.000e+0	45.40	PREDICTED: LOW QUALITY PROTEIN: 3-hydroxy-3-methyl...	[more]
gi\|1285022143\|ref\|XP_023023291.1\|	0.000e+0	46.54	3-hydroxy-3-methylglutaryl-coenzyme A reductase-li...	[more]
gi\|859132811\|gb\|AKO63319.1\|	0.000e+0	46.32	3-hydroxy-3-methylglutaryl coenzyme A reductase 2 ...	[more]
gi\|1285022145\|ref\|XP_023023292.1\|	0.000e+0	46.54	3-hydroxy-3-methylglutaryl-coenzyme A reductase-li...	[more]
gi\|91082547\|ref\|XP_973850.1\|	0.000e+0	45.00	PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A r...	[more]
gi\|1080036668\|ref\|XP_018578730.1\|	0.000e+0	46.41	3-hydroxy-3-methylglutaryl-coenzyme A reductase [A...	[more]

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Alignments

The following features are aligned


Aligned Feature	Feature Type	Alignment Location
scaffold208_size258758	supercontig	scaffold208_size258758:99540..102365 +

Analyses

This gene is derived from or has results from the following analyses


Analysis Name	Date Performed
maker	2018-02-12 .496401
T. kinsejongensis vs L. Salmonis peptides	2018-04-19
T. kingejongensis peptided Blastp vs. SwissProt	2018-04-19
T. kingsejongensis proteins Blastp vs. NR	2018-05-15

Properties


Property Name	Value
Note	C:integral to membrane

Relationships

The following mRNA feature(s) are a part of this gene:


Feature Name	Unique Name	Species	Type
snap_masked-scaffold208_size258758-processed-gene-1.0-mRNA-1	snap_masked-scaffold208_size258758-processed-gene-1.0-mRNA-1	Tigriopus kingsejongensis	mRNA

Sequences

The following sequences are available for this feature:

gene from alignment at scaffold208_size258758:99540..102365+

gene from alignment at scaffold208_size258758:99540..102365+

Legend: mRNA

Hold the cursor over a type above to highlight its positions in the sequence below.

>snap_masked-scaffold208_size258758-processed-gene-1.0 ID=snap_masked-scaffold208_size258758-processed-gene-1.0|Name=3-hydroxy-3-methylglutaryl- reductase|organism=Tigriopus kingsejongensis|type=gene|length=2826bp|location=Sequence derived from alignment at scaffold208_size258758:99540..102365+ (Tigriopus kingsejongensis)
ATGGAGGTTCAAGCTCCCCTGAAACCCTCAAAAGTGGCAATTGCGGCCAC
AAACAGCACTTCTTCTTCGGATCGCCACACACCGGAGGAACAACAATCAC
GAAGCCTCCCAACCCTCTTTATTCGAAAGATCTTTAAATCTCACGGGGAA
TTCTGTGCTAGCCAACCGTGGGAAGTGATTGTGACCACTTTCATCTTTCT
GATTTGCGTCCTCACCGTTGGGAGCAAGCACGTCATGATGGTGACGGAAA
TGGATTCATCCGCGAGTTCCAAGATCAAGCCTTGCCTTCCAAGCGACCCT
TCCTGTGTACCGGAGCATCACTCCAGGGATTGGATTGAAACTTTGGTCAT
GGCTGGCTTCTATTGCCTGGCAGTTCTGCACATTACCTATCGCTTCAAGA
AGATCCATCTGATCCGCTCCAACTTGATCTTCAACATCGCCTTGTGCTAT
ATGACCTTTGCATCGCTGCTTTACGCCCTGATCATCTGGAGCATTGGAAA
CCCTCTAAAGGATAATCTCCACCAGGCTTGGTTCCTGATTTTCCTCCTGG
TTGACATGCAGAAAGTGACCCGGATGGGACAATTTGCCCTGAGCTCATCG
CACCATCGCCGAATTAGCGAGAACGTGGCTAATGGCATGTATGTCTTGGC
TCCCACCTTTGCATTGGATTGCTTGGCTAAGATCTTTCTGGTTGGATTAG
GATCGCTGACAAGAATACCCCAACTGGAGGCCTTCTCTTGGTATGCCGTT
GTCTCAGTCATGGTAAATTTCTTGGTTTACTTGACCTTCTACCCCGCTGG
CTTATCTCTGGTCCTGGAACTCATGTACTGCACGGATGGAAGACCACGAT
GGGACGTGCGACAGATAATCAACACCCTGCCCGGGGAGGACGGCCAGACC
CCTGTGGTGCACCGGGTCAAAGTGGTAGCCACGGCTCTTCTGATGATCGC
CCATATAATCTTCCGCCCTCCATTCTTATTCAGCAGTGCGAGTGGAATCT
CCCAGCCCACAACAACCCTATTCTCTTGGGCCACCACCAACATCGAGAAA
GTTCTCATTACTGTGGTGATTGTGGCACTGTCGATCAAGTACCTCTTCTA
CGAGGATATGGACGAGGCTCAAGAGCTGAGAAAAACCTACATCGAGGAGC
TCACACGAAAATTTGCAGAGGACAGTGAACAAGAAGAATTCAACCGCGGC
AACAAAGTCGAGATGGACAGGGTTTCCAATTCCACTGATGAAGGAATCAG
CATTGGCAGCTCGGCGAAACCTCGCCCCCCGTCCTGTGCCTCTCGACATG
GAGACGATTCGAGTAGCGAGTCTGCTTGGTCGGAGGTTGGTTACTTACCT
GATCTCAAAGACCAAGAAGCTCAAACCACTGACATGGCATCATCTGAAGA
TGAGGTCGACGATGACGAAAATGGCGAGAAAAGACGTATTCGACACCACC
ATCAACTTCCCAAGGAGCCGCGGAGCTTGGAGGAATGCACAAAGATCTAC
AAAGGGACCATGGACGGTGTGGAATATCTCATCGATGAAGAAGTGGTTCA
TTTGGTCGAGAAGAAAGTGATACGTGCTCATGCCCTGGAGAGTGTCTTGA
ACAATCCCACCCGAGGTGTGGAGATCCGACGCAAATACGTCGAGAAAGTG
GCCAAGAGAGACATTGGAAACCTCCCTTTTAGAAACTTTGACTACGACAC
TGTGATGGGTGCCTGTTGCGAGAGTGTAATAGGCTACATGACCATGCCTG
TTGGGGTCGCGGGACCCTTGAACTTGGATGGCCAATTGTTCTATGTTCCT
ATGGCAACCACGGAAGGATGCCTGGTGGCGAGCGTAAACCGTGGCTGTAG
TGCATTGAGAACATGCGGGGTGACAAGCCGCATCCTCGCCGACGGAATGA
CTCGGGGCCCCATCGTTCGCTTCCCCAACATTGCAAAAATGGCCGAGGCC
AAGGAGTGGATGGAGGAGCCCGAAAACTTCCTACAAATCAAAAGTAACTT
CGACAGTACAAGTCGGTTTGCAAGACTCCAAAGACTAAAACTTAAGCCTG
CAGGACGTGAGCTCTACATTCGCTTCGTGGCCTACACGGGTGATGCCATG
GGTATGAACATGATTTCCAAAGCCGCAGAATTTTCGCTCAAGCAGTTGAT
AGATGTCTTCCCCGAGATGGAATTAGTCAGCCTAAGTGGAAACATGTGCA
CCGATAAGAAGCCAGCAGCCATCAATTGGTTGGACGGCAGAGGAAAATCA
GTCATTTGCGAGGCCACAGTTCCGGGGCACATTGTCGAGACGGTTCTCAA
GACCTCCCCTGCCGCTCTCGCAGATCTCAACAGATCCAAAAACTTGGTTG
GTTCGGCCATGGCCGGCAGCATTGGAGGCTTCAACGCCCAAGCCGCCAAC
GTGGTGACGGCCGTGTTTATCGCCACAGGGCAGGACGCAGCTCAAAACGT
GGCCAGCAGCAACTGCCTCACCCAGATCGATGTGGTGGGTGACGACCTCT
ACATGACTTGCACAATGCCTTCCATTGAGGTTGGTACCGTGGGAGGTGGA
ACTATACTGACGGCTCAGGGGGCCTGCCTCGATCTGCTTGGCGTCAAGGG
ATGTCAACCCGCCTCCCCTGGCGCTAATGCAAAGCAACTGGCCAGTGTGG
TATGTGCCACTGTCTTAGCCGGAGAGCTCTCCTTAATGTCAGCCCTCGCA
GCTGGCCATCTGGTGAAAAGCCACCTGAGGCACAACCGATCAAATCTCGC
AGTGGGCTCTGTTGCGGGTCCAGAATCCATGGCCAAACCCATGCTCTGTA
TTCATCCCAATGCCTCCGTGCCCTAG

Synonyms

The feature '3-hydroxy-3-methylglutaryl- reductase' has the following synonyms


Synonym
Tk04201

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