Salmon louse rhabdoviruses: Impact on louse development and transcription of selected Atlantic salmon immune genes

Overview
TitleSalmon louse rhabdoviruses: Impact on louse development and transcription of selected Atlantic salmon immune genes
AuthorsØvergård AC, Hamre LA, Grotmol S, Nilsen F
TypeJournal Article
Journal NameDevelopmental and comparative immunology
Volume86
IssueN/A
Year2018
Page(s)86-95
CitationØvergård AC, Hamre LA, Grotmol S, Nilsen F. Salmon louse rhabdoviruses: Impact on louse development and transcription of selected Atlantic salmon immune genes. Developmental and comparative immunology. 2018 Apr 30; 86:86-95.

Abstract

Recently, it has been shown that the salmon louse (Lepeophtheirus salmonis) is commonly infected by one or two vertically transmitted Lepeophtheirus salmonis rhabdoviruses (LsRVs). As shown in the present study, the viruses have limited effect on louse survival, developmental rate and fecundity. Since the LsRVs were confirmed to be present in the louse salivary glands, the salmon cutaneous immune response towards LsRV positive and negative lice was analyzed. In general, L. salmonis increased the expression of IL1β, IL8 and IL4/13A at the attachment site, in addition to the non-specific cytotoxic cell receptor protein 1 (NCCRP-1). Interestingly, LsRV free lice induced a higher skin expression of IL1β, IL8, and NCCRP-1 than the LsRV infected lice. The inflammatory response is important for louse clearance, and the present results suggest that the LsRVs can be beneficial for the louse by dampening inflammation. Further research is, however; needed to ascertain whether this is a direct modulatory effect of secreted virions, or if virus replication is altering the level of louse salivary gland proteins.

Author Details
Additional information about authors:
Details
1Aina-Cathrine Øvergård
2Lars Are Hamre
3Sindre Grotmol
4Frank Nilsen
Properties
Additional details for this publication include:
Property NameValue
Journal CountryUnited States
Publication TypeJournal Article
Language Abbreng
LanguageEnglish
CopyrightCopyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI10.1016/j.dci.2018.04.023
Elocation10.1016/j.dci.2018.04.023
PIIS0145-305X(18)30135-6
Journal AbbreviationDev. Comp. Immunol.
Publication Date2018 Apr 30
eISSN1879-0089
ISSN1879-0089
Publication ModelPrint-Electronic
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PMID: PMID:29747070