Anti-chemotactic activity in the secretory/excretory products of Lepeophtheirus salmonis

Overview
TitleAnti-chemotactic activity in the secretory/excretory products of Lepeophtheirus salmonis
AuthorsPiesz JL, Barker SE, Bricknell IR
TypeJournal Article
Journal NameFish & shellfish immunology
Volume98
IssueN/A
Year2020
Page(s)296-300
CitationPiesz JL, Barker SE, Bricknell IR. Anti-chemotactic activity in the secretory/excretory products of Lepeophtheirus salmonis. Fish & shellfish immunology. 2020 Jan 14; 98:296-300.

Abstract

The ectoparasite, Lepeophtheirus salmonis (Kroyer 1837), is effective at avoiding elimination from its host, Atlantic salmon, Salmo salar L., by inhibiting the recruitment of immune cells to the site of attachment. In other ectoparasitic arthropods, numerous factors have been identified that bind or neutralize chemokines preventing their interaction with receptors on the surfaces of immune cells. To determine if L. salmonis is utilizing a similar mechanism of immune modulation, the chemotactic activity of peripheral blood leukocytes (PBL) to leukotriene B4 (LTB4) and the secreted/excreted products (SEPs) of the sea louse were investigated in vitro. The results showed that incubation of LTB4 with SEPs reduced leukocyte migration compared to LTB4 immune stimulation alone. Data suggests that one of the mechanisms L. salmonis may be using to regulate immune cell recruitment in Atlantic salmon is by inhibiting or neutralizing the activity of chemokines.

Author Details
Additional information about authors:
Details
1Jessica L Piesz
2Sarah E Barker
3Ian R Bricknell
Properties
Additional details for this publication include:
Property NameValue
Journal CountryEngland
Publication TypeJournal Article
Language Abbreng
LanguageEnglish
CopyrightCopyright © 2020 Elsevier Ltd. All rights reserved.
DOI10.1016/j.fsi.2020.01.023
Elocation10.1016/j.fsi.2020.01.023
PIIS1050-4648(20)30023-1
Journal AbbreviationFish Shellfish Immunol.
Publication Date2020 Jan 14
eISSN1095-9947
ISSN1095-9947
Publication ModelPrint-Electronic
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PMID: PMID:31945482