Chimeric Protein IPath

Overview
TitleChimeric Protein IPath
AuthorsValenzuela-Muñoz V, Benavente BP, Casuso A, Leal Y, Gallardo-Escárate C
TypeJournal Article
Journal NameVaccines
Volume9
Issue4
Year2021
Page(s)N/A
CitationValenzuela-Muñoz V, Benavente BP, Casuso A, Leal Y, Gallardo-Escárate C. Chimeric Protein IPath. Vaccines. 2021 Apr 09; 9(4).

Abstract

Infection processes displayed by pathogens require the acquisition of essential inorganic nutrients and trace elements from the host to survive and proliferate. Without a doubt, iron is a crucial trace metal for all living organisms and also a pivotal component in the host-parasite interactions. In particular, the host reduces the iron available to face the infectious disease, increasing iron transport proteins' expression and activating the heme synthesis and degradation pathways. Moreover, recent findings have suggested that iron metabolism modulation in fish promotes the immune response by reducing cellular iron toxicity. We hypothesized that recombinant proteins related to iron metabolism could modulate the fish's immune system through iron metabolism and iron-responsive genes. Here a chimeric iron transport protein (IPath

Properties
Additional details for this publication include:
Property NameValue
Journal CountrySwitzerland
Publication TypeJournal Article
Language Abbreng
LanguageEnglish
DOI10.3390/vaccines9040361
Elocation10.3390/vaccines9040361
PII361
Journal AbbreviationVaccines (Basel)
Publication Date2021 Apr 09
pISSN2076-393X
ISSN2076-393X
Publication ModelElectronic
Cross References
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DatabaseAccession
PMID: PMID:33918540