Roles of three putative salmon louse (Lepeophtheirus salmonis) prostaglandin E

Overview
TitleRoles of three putative salmon louse (Lepeophtheirus salmonis) prostaglandin E
AuthorsDalvin S, Eichner C, Dondrup M, Øvergård AC
TypeJournal Article
Journal NameParasites & vectors
Volume14
Issue1
Year2021
Page(s)206
CitationDalvin S, Eichner C, Dondrup M, Øvergård AC. Roles of three putative salmon louse (Lepeophtheirus salmonis) prostaglandin E. Parasites & vectors. 2021 Apr 19; 14(1):206.

Abstract

BACKGROUND
The salmon louse (Lepeophtheirus salmonis) is a parasite of salmonid fish. Atlantic salmon (Salmo salar) exhibit only a limited and ineffective immune response when infested with this parasite. Prostaglandins (PGs) have many biological functions in both invertebrates and vertebrates, one of which is the regulation of immune responses. This has led to the suggestion that prostaglandin E

METHODS
Lepeophtheirus salmonis microsomal glutathione S-transferase 1 like (LsMGST1L) and LsPGES3L were investigated by sequencing, phylogenetics, transcript localization and expression studies. Moreover, the function of these putative PGES genes in addition to the previously identified LsPGES2 gene was analyzed in double stranded (ds) RNA-mediated knockdown (KD) salmon louse.

RESULTS
Analysis of the three putative LsPGES genes showed a rather constitutive transcript level throughout development from nauplius to the adult stages, and in a range of tissues, with the highest levels in the ovaries or gut. DsRNA-mediated KD of these transcripts did not produce any characteristic changes in phenotype, and KD animals displayed a normal reproductive output. The ability of the parasite to infect or modulate the immune response of the host fish was also not affected by KD.

CONCLUSIONS
Salmon louse prostaglandins may play endogenous roles in the management of reproduction and oxidative stress and may be a product of salmon louse blood digestions.

Author Details
Additional information about authors:
Details
1Sussie Dalvin
2Christiane Eichner
3Michael Dondrup
4Aina-Cathrine Øvergård
Properties
Additional details for this publication include:
Property NameValue
Journal CountryEngland
Publication TypeJournal Article
Language Abbreng
LanguageEnglish
ISSN1756-3305
Publication ModelElectronic
Elocation10.1186/s13071-021-04690-w
DOI10.1186/s13071-021-04690-w
Journal AbbreviationParasit Vectors
Publication Date2021 Apr 19
eISSN1756-3305
Cross References
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DatabaseAccession
PMID: PMID:33874988