BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:sel-12 "Presenilin sel-12" species:6239 "Caenorhabditis elegans" [GO:0000139 "Golgi membrane" evidence=IEA] [GO:0001708 "cell fate specification" evidence=IMP] [GO:0004175 "endopeptidase activity" evidence=IBA] [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0005515 "protein binding" evidence=IPI] [GO:0005634 "nucleus" evidence=IBA] [GO:0005743 "mitochondrial inner membrane" evidence=IBA] [GO:0005765 "lysosomal membrane" evidence=IBA] [GO:0005783 "endoplasmic reticulum" evidence=IEA] [GO:0005789 "endoplasmic reticulum membrane" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IBA] [GO:0005938 "cell cortex" evidence=IBA] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=IBA] [GO:0006816 "calcium ion transport" evidence=IBA] [GO:0007219 "Notch signaling pathway" evidence=IEA;NAS] [GO:0007220 "Notch receptor processing" evidence=IBA] [GO:0007399 "nervous system development" evidence=IEA;IMP] [GO:0009986 "cell surface" evidence=IBA] [GO:0016020 "membrane" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0016048 "detection of temperature stimulus" evidence=IMP] [GO:0016324 "apical plasma membrane" evidence=IBA] [GO:0017015 "regulation of transforming growth factor beta receptor signaling pathway" evidence=IGI] [GO:0018991 "oviposition" evidence=IEA;IMP] [GO:0030018 "Z disc" evidence=IBA] [GO:0030424 "axon" evidence=IBA] [GO:0030426 "growth cone" evidence=IBA] [GO:0031594 "neuromuscular junction" evidence=IBA] [GO:0035253 "ciliary rootlet" evidence=IBA] [GO:0042987 "amyloid precursor protein catabolic process" evidence=IBA] [GO:0043025 "neuronal cell body" evidence=IBA] [GO:0043198 "dendritic shaft" evidence=IBA] [GO:0045121 "membrane raft" evidence=IBA] [GO:0045176 "apical protein localization" evidence=IDA] [GO:0045747 "positive regulation of Notch signaling pathway" evidence=IGI] [GO:0048471 "perinuclear region of cytoplasm" evidence=IDA] [GO:0048563 "post-embryonic organ morphogenesis" evidence=IMP] [GO:0050435 "beta-amyloid metabolic process" evidence=IBA] InterPro:IPR001108 InterPro:IPR001686 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01075 SMART:SM00730 GO:GO:0005938 GO:GO:0005634 GO:GO:0001708 GO:GO:0048471 GO:GO:0030424 GO:GO:0007399 GO:GO:0009986 GO:GO:0000139 GO:GO:0005887 GO:GO:0030018 GO:GO:0045121 GO:GO:0005765 GO:GO:0005743 GO:GO:0005789 GO:GO:0016324 GO:GO:0043198 GO:GO:0043025 GO:GO:0004190 GO:GO:0035253 GO:GO:0031594 GO:GO:0007219 GO:GO:0018991 GO:GO:0045747 GO:GO:0042987 GO:GO:0030426 GO:GO:0004175 GO:GO:0006816 GO:GO:0050435 GO:GO:0006509 GO:GO:0007220 GO:GO:0048563 GO:GO:0045176 GO:GO:0017015 GO:GO:0016048 GeneTree:ENSGT00390000016593 PANTHER:PTHR10202 eggNOG:NOG237920 HOGENOM:HOG000240228 KO:K04505 OrthoDB:EOG7NGQBG OMA:VIQGWLF EMBL:U35660 EMBL:AF171064 EMBL:FO081301 RefSeq:NP_508175.1 UniGene:Cel.19557 ProteinModelPortal:P52166 SMR:P52166 BioGrid:45394 MEROPS:A22.009 PaxDb:P52166 PRIDE:P52166 EnsemblMetazoa:F35H12.3 GeneID:180441 KEGG:cel:CELE_F35H12.3 UCSC:F35H12.3 CTD:180441 WormBase:F35H12.3 InParanoid:P52166 SignaLink:P52166 NextBio:909386 PRO:PR:P52166 Uniprot:P52166)

HSP 1 Score: 384.415 bits (986), Expect = 1.338e-128
Identity = 208/413 (50.36%), Postives = 273/413 (66.10%), Query Frame = 0

Query:   15 RREVQELEE--EEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVI--------------------------GMADSSSD-PKRPNRRRDNQRMAAESQX-------------QELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSR 385
             R  QE E   EE  + +GA +VI LF PV+LCMA VV T+ ++T Y++ +G +L+YTPF   +D+       +  NA ++L V+ +MTV+LI+ YKYK   LIHGWL +SSF+LLFLF+ I++ EVLK++++    + + F + N+GV+GMM IHWK PL LQQ YLI +SAL+AL FIKYLP +T W VL  IS+W L AVL P GPLR LVETAQERNEPIFP+LIYS+G++Y  +                          G A  SS+ PKRP  +R  Q++  ES               +EL+      Q       EEE+RG+KLGLGDFIFYS+L+GKASSY DWNTT+AC+VAILIGLC TL+ LA+F++ALPALPISI  GLIFYF T+ IITPF+ ++S +
Sbjct:   28 NRNSQEDENVVEEAELKYGASHVIHLFVPVSLCMALVVFTMNTITFYSQNNGRHLLYTPFVRETDSIVEKGLMSLGNALVMLCVVVLMTVLLIVFYKYKFYKLIHGWLIVSSFLLLFLFTTIYVQEVLKSFDVSPSALLVLFGLGNYGVLGMMCIHWKGPLRLQQFYLITMSALMALVFIKYLPEWTVWFVLFVISVWDLVAVLTPKGPLRYLVETAQERNEPIFPALIYSSGVIYPYVLVTAVENTTDPREPTSSDSNTSTAFPGEASCSSETPKRPKVKRIPQKVQIESNTTASTTQNSGVRVERELAAERPTVQDANFHRHEEEERGVKLGLGDFIFYSVLLGKASSYFDWNTTIACYVAILIGLCFTLVLLAVFKRALPALPISIFSGLIFYFCTRWIITPFVTQVSQK 440          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:PSEN1 "Presenilin-1" species:9031 "Gallus gallus" [GO:0000045 "autophagic vacuole assembly" evidence=IEA] [GO:0000122 "negative regulation of transcription from RNA polymerase II promoter" evidence=IEA] [GO:0000139 "Golgi membrane" evidence=IEA] [GO:0000186 "activation of MAPKK activity" evidence=IEA] [GO:0000776 "kinetochore" evidence=IEA] [GO:0001568 "blood vessel development" evidence=IEA] [GO:0001708 "cell fate specification" evidence=IEA] [GO:0001756 "somitogenesis" evidence=IEA] [GO:0001764 "neuron migration" evidence=IEA] [GO:0001921 "positive regulation of receptor recycling" evidence=IEA] [GO:0001947 "heart looping" evidence=IEA] [GO:0002244 "hematopoietic progenitor cell differentiation" evidence=IEA] [GO:0002286 "T cell activation involved in immune response" evidence=IEA] [GO:0002573 "myeloid leukocyte differentiation" evidence=IEA] [GO:0004175 "endopeptidase activity" evidence=IBA] [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0005262 "calcium channel activity" evidence=IEA] [GO:0005634 "nucleus" evidence=IBA] [GO:0005640 "nuclear outer membrane" evidence=IEA] [GO:0005739 "mitochondrion" evidence=ISS] [GO:0005743 "mitochondrial inner membrane" evidence=IBA] [GO:0005765 "lysosomal membrane" evidence=IBA] [GO:0005783 "endoplasmic reticulum" evidence=ISS;IBA] [GO:0005789 "endoplasmic reticulum membrane" evidence=IEA] [GO:0005790 "smooth endoplasmic reticulum" evidence=IEA] [GO:0005791 "rough endoplasmic reticulum" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=ISS] [GO:0005813 "centrosome" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=ISS;IBA] [GO:0005938 "cell cortex" evidence=IBA] [GO:0006486 "protein glycosylation" evidence=IEA] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=ISS;IBA] [GO:0006816 "calcium ion transport" evidence=IBA] [GO:0006839 "mitochondrial transport" evidence=IEA] [GO:0006974 "cellular response to DNA damage stimulus" evidence=IEA] [GO:0006979 "response to oxidative stress" evidence=IEA] [GO:0007175 "negative regulation of epidermal growth factor-activated receptor activity" evidence=IEA] [GO:0007219 "Notch signaling pathway" evidence=IEA] [GO:0007220 "Notch receptor processing" evidence=IBA] [GO:0007613 "memory" evidence=IEA] [GO:0008013 "beta-catenin binding" evidence=IEA] [GO:0009791 "post-embryonic development" evidence=IEA] [GO:0009986 "cell surface" evidence=IBA] [GO:0015031 "protein transport" evidence=IEA] [GO:0015813 "L-glutamate transport" evidence=IEA] [GO:0015871 "choline transport" evidence=IEA] [GO:0016080 "synaptic vesicle targeting" evidence=IEA] [GO:0016324 "apical plasma membrane" evidence=IBA] [GO:0016337 "cell-cell adhesion" evidence=IEA] [GO:0016485 "protein processing" evidence=ISS] [GO:0021795 "cerebral cortex cell migration" evidence=IEA] [GO:0021870 "Cajal-Retzius cell differentiation" evidence=IEA] [GO:0021904 "dorsal/ventral neural tube patterning" evidence=IEA] [GO:0030018 "Z disc" evidence=IBA] [GO:0030165 "PDZ domain binding" evidence=IEA] [GO:0030326 "embryonic limb morphogenesis" evidence=IEA] [GO:0030424 "axon" evidence=IBA] [GO:0030426 "growth cone" evidence=IBA] [GO:0031410 "cytoplasmic vesicle" evidence=IEA] [GO:0031594 "neuromuscular junction" evidence=IBA] [GO:0032436 "positive regulation of proteasomal ubiquitin-dependent protein catabolic process" evidence=IEA] [GO:0034205 "beta-amyloid formation" evidence=IEA] [GO:0035253 "ciliary rootlet" evidence=IBA] [GO:0035556 "intracellular signal transduction" evidence=IEA] [GO:0042325 "regulation of phosphorylation" evidence=ISS] [GO:0042640 "anagen" evidence=IEA] [GO:0042987 "amyloid precursor protein catabolic process" evidence=IBA] [GO:0043025 "neuronal cell body" evidence=IBA] [GO:0043065 "positive regulation of apoptotic process" evidence=IEA] [GO:0043066 "negative regulation of apoptotic process" evidence=IEA] [GO:0043085 "positive regulation of catalytic activity" evidence=ISS] [GO:0043198 "dendritic shaft" evidence=IBA] [GO:0043393 "regulation of protein binding" evidence=IEA] [GO:0043406 "positive regulation of MAP kinase activity" evidence=IEA] [GO:0043589 "skin morphogenesis" evidence=IEA] [GO:0045121 "membrane raft" evidence=IBA] [GO:0045296 "cadherin binding" evidence=IBA] [GO:0048167 "regulation of synaptic plasticity" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IBA] [GO:0048538 "thymus development" evidence=IEA] [GO:0048666 "neuron development" evidence=IEA] [GO:0048705 "skeletal system morphogenesis" evidence=IEA] [GO:0048854 "brain morphogenesis" evidence=IEA] [GO:0050435 "beta-amyloid metabolic process" evidence=IBA] [GO:0050673 "epithelial cell proliferation" evidence=IEA] [GO:0050771 "negative regulation of axonogenesis" evidence=IEA] [GO:0050820 "positive regulation of coagulation" evidence=IEA] [GO:0050852 "T cell receptor signaling pathway" evidence=IEA] [GO:0051402 "neuron apoptotic process" evidence=IEA] [GO:0051444 "negative regulation of ubiquitin-protein ligase activity" evidence=IEA] [GO:0051563 "smooth endoplasmic reticulum calcium ion homeostasis" evidence=IBA] [GO:0051966 "regulation of synaptic transmission, glutamatergic" evidence=IEA] [GO:0060075 "regulation of resting membrane potential" evidence=IEA] [GO:0070765 "gamma-secretase complex" evidence=IEA] [GO:2000059 "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" evidence=IEA] [GO:2001234 "negative regulation of apoptotic signaling pathway" evidence=IEA] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01073 SMART:SM00730 GO:GO:0005783 GO:GO:0005938 GO:GO:0005634 GO:GO:0001708 GO:GO:0005794 GO:GO:0048471 GO:GO:0043085 GO:GO:0000186 GO:GO:0001764 GO:GO:0030424 GO:GO:0048167 GO:GO:0043066 GO:GO:0009986 GO:GO:0000139 GO:GO:0005887 GO:GO:0006979 GO:GO:0042325 GO:GO:0030018 GO:GO:0000776 GO:GO:0005813 GO:GO:0045121 GO:GO:0005765 GO:GO:0050852 GO:GO:0005743 GO:GO:0005789 GO:GO:0035556 GO:GO:0015031 GO:GO:0016324 GO:GO:0043198 GO:GO:0043025 GO:GO:0007613 GO:GO:0043406 GO:GO:0005262 GO:GO:0005791 GO:GO:0004190 GO:GO:0000045 GO:GO:0006486 GO:GO:0035253 GO:GO:0031410 GO:GO:0031594 GO:GO:0051402 GO:GO:0043393 GO:GO:0051563 GO:GO:0007219 GO:GO:0006974 GO:GO:0043065 GO:GO:0042987 GO:GO:0000122 GO:GO:0030426 GO:GO:0001756 GO:GO:0009791 GO:GO:0030326 GO:GO:0004175 GO:GO:0048666 GO:GO:0006816 GO:GO:0050435 GO:GO:0016337 GO:GO:0006509 GO:GO:0007220 GO:GO:0048538 GO:GO:0006839 GO:GO:0001568 GO:GO:0001921 GO:GO:0001947 GO:GO:0005640 GO:GO:0042640 GO:GO:0032436 GO:GO:0016485 GO:GO:0045296 GO:GO:0048705 GO:GO:0070765 GO:GO:0050771 GO:GO:0051444 GO:GO:2001234 GO:GO:0048854 GO:GO:0021904 GO:GO:0005790 GO:GO:0007175 GO:GO:0002286 GO:GO:0043589 GO:GO:0050673 GO:GO:0002244 GO:GO:0051966 GO:GO:0060075 GO:GO:0016080 GO:GO:0021795 GO:GO:0015813 GO:GO:2000059 GO:GO:0034205 GO:GO:0002573 GeneTree:ENSGT00390000016593 PANTHER:PTHR10202 GO:GO:0050820 MEROPS:A22.001 CTD:5663 eggNOG:NOG237920 HOGENOM:HOG000240228 HOVERGEN:HBG011375 KO:K04505 OMA:EAQRKVS TreeFam:TF315040 GO:GO:0021870 GO:GO:0015871 PANTHER:PTHR10202:SF7 EMBL:AY043492 EMBL:DQ084362 RefSeq:NP_989494.1 UniGene:Gga.3864 STRING:9031.ENSGALP00000015151 PaxDb:Q4JIM4 Ensembl:ENSGALT00000032629 GeneID:373977 KEGG:gga:373977 InParanoid:Q4JIM4 OrthoDB:EOG7NGQBG NextBio:20813506 PRO:PR:Q4JIM4 Uniprot:Q4JIM4)

HSP 1 Score: 380.948 bits (977), Expect = 6.964e-127
Identity = 223/397 (56.17%), Postives = 284/397 (71.54%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKR---PNRRRDNQRMAAESQXQELSPPP------LQQQQQP---PVE-------------------EEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT +DG  L+YTPF E +D  G  A N+  NA I+++VI VMT++L++ YKY+C  +IHGWL +SS +LLF FS+I+LGEV KTYN+ MDYIT+A I+WNFGVVGM+ IHWK PL LQQ+YLI ISAL+AL FIKYLP +T W +LA IS++ L AVL P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MA+   + +R    N   D Q  A +SQ ++            QQQ+     P+E                   E+ E+RG+KLGLGDFIFYS+LVGKAS+   GDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGL+FYF T  ++ PFMD+++  Q YI
Sbjct:   74 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQ-LIYTPFTEETDTIGQRALNSILNAAIMISVIIVMTILLVVLYKYRCYKVIHGWLIISSLLLLFFFSFIYLGEVFKTYNVAMDYITVALIIWNFGVVGMICIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEEDPEGQRKASKNSTYDKQAPANQSQNEDAEADDGGFSQEWQQQRDNRIGPIESTPESRAAVQALPSNSQTSEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVQPFMDQLAFHQFYI 468          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:psen1 "Uncharacterized protein" species:8364 "Xenopus (Silurana) tropicalis" [GO:0004175 "endopeptidase activity" evidence=IBA] [GO:0005634 "nucleus" evidence=IBA] [GO:0005739 "mitochondrion" evidence=ISS] [GO:0005743 "mitochondrial inner membrane" evidence=IBA] [GO:0005765 "lysosomal membrane" evidence=IBA] [GO:0005783 "endoplasmic reticulum" evidence=ISS;IBA] [GO:0005794 "Golgi apparatus" evidence=ISS] [GO:0005887 "integral component of plasma membrane" evidence=ISS;IBA] [GO:0005938 "cell cortex" evidence=IBA] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=ISS;IBA] [GO:0006816 "calcium ion transport" evidence=IBA] [GO:0007220 "Notch receptor processing" evidence=IBA] [GO:0009986 "cell surface" evidence=IBA] [GO:0016324 "apical plasma membrane" evidence=IBA] [GO:0016485 "protein processing" evidence=ISS] [GO:0030018 "Z disc" evidence=IBA] [GO:0030424 "axon" evidence=IBA] [GO:0030426 "growth cone" evidence=IBA] [GO:0031594 "neuromuscular junction" evidence=IBA] [GO:0035253 "ciliary rootlet" evidence=IBA] [GO:0042987 "amyloid precursor protein catabolic process" evidence=IBA] [GO:0043025 "neuronal cell body" evidence=IBA] [GO:0043085 "positive regulation of catalytic activity" evidence=ISS] [GO:0043198 "dendritic shaft" evidence=IBA] [GO:0045121 "membrane raft" evidence=IBA] [GO:0045296 "cadherin binding" evidence=IBA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IBA] [GO:0050435 "beta-amyloid metabolic process" evidence=IBA] [GO:0051563 "smooth endoplasmic reticulum calcium ion homeostasis" evidence=IBA] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 SMART:SM00730 GO:GO:0005783 GO:GO:0005938 GO:GO:0005634 GO:GO:0005794 GO:GO:0048471 GO:GO:0043085 GO:GO:0030424 GO:GO:0009986 GO:GO:0005887 GO:GO:0030018 GO:GO:0045121 GO:GO:0005765 GO:GO:0005743 GO:GO:0035556 GO:GO:0016324 GO:GO:0043198 GO:GO:0043025 GO:GO:0004190 GO:GO:0035253 GO:GO:0031594 GO:GO:0051563 GO:GO:0042987 GO:GO:0030426 GO:GO:0004175 GO:GO:0006816 GO:GO:0050435 GO:GO:0006509 GO:GO:0007220 GO:GO:0016485 GO:GO:0045296 GeneTree:ENSGT00390000016593 PANTHER:PTHR10202 MEROPS:A22.001 CTD:5663 eggNOG:NOG237920 HOGENOM:HOG000240228 HOVERGEN:HBG011375 KO:K04505 PANTHER:PTHR10202:SF7 EMBL:AAMC01110598 EMBL:BC064246 RefSeq:NP_001027027.1 UniGene:Str.1414 STRING:8364.ENSXETP00000002205 Ensembl:ENSXETT00000002205 GeneID:394924 KEGG:xtr:394924 Xenbase:XB-GENE-481916 InParanoid:Q6P2Y8 Uniprot:Q6P2Y8)

HSP 1 Score: 376.711 bits (966), Expect = 1.087e-125
Identity = 226/398 (56.78%), Postives = 283/398 (71.11%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSS------------------SDPKRPNRRRDNQ---RMAAESQXQEL-----SPPPLQQQQQ------PPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT  DG  L+YTPF E +D+ G  A N+  N  I+++VI VMT++L++ YKY+C  +IHGWL +SS +LLF FSYI+LGEV KTYN+ MDYITLA ++WNFGVVGM+ IHWK PLLLQQ+YLI ISAL+AL FIKYLP +TTW +LA IS++ L AVL+P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MAD                    + P+  +   D+      A E Q  E      S P  +   Q      PP E+ EE RG+KLGLGDFIFYS+LVGKAS+   GDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGL+FYF T  ++ PFMD+++  Q YI
Sbjct:   39 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRYDGQ-LIYTPFTEDTDSVGQRALNSILNTAIMISVIIVMTILLVVLYKYRCYKVIHGWLIISSLLLLFFFSYIYLGEVFKTYNVAMDYITLALMIWNFGVVGMICIHWKGPLLLQQAYLIMISALMALVFIKYLPEWTTWLILAVISVYDLIAVLSPKGPLRMLVETAQERNETLFPALIYSSTMIW-LVKMADGDPGFKQSASKKTYNAQAPVAQPRSDSAASDDNGGFDTAWEEQRNEQIGQINSTPESRAAVQALPSNNPPSEDPEE-RGVKLGLGDFIFYSVLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 433          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:PSEN1 "Uncharacterized protein" species:9823 "Sus scrofa" [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0035556 "intracellular signal transduction" evidence=IEA] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01073 SMART:SM00730 GO:GO:0016021 GO:GO:0008152 GO:GO:0035556 GO:GO:0004190 GeneTree:ENSGT00390000016593 PANTHER:PTHR10202 OMA:EAQRKVS TreeFam:TF315040 PANTHER:PTHR10202:SF7 OrthoDB:EOG7NGQBG EMBL:CU914658 EMBL:CU855510 Ensembl:ENSSSCT00000002603 ArrayExpress:F1S3K9 Uniprot:F1S3K9)

HSP 1 Score: 372.474 bits (955), Expect = 1.339e-123
Identity = 212/396 (53.54%), Postives = 279/396 (70.45%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQRMAAESQXQE---------------------LSPPPLQQQQQP---------PVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT +DG  L+YTPF E ++  G  A ++  NA I+++VI VMT++L++ YKY+C  +IH WL +SS +LLF FS+I+LGEV KTYN+ MDYIT+A ++WNFGVVGM++IHWK PL LQQ+YLI ISAL+AL FIKYLP +T W +LA IS++ L AVL P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MA+   + +R   +  N    +  + Q+                     L P     + +          P  E+ E+RG+KLGLGDFIFYS+LVGKAS+   GDWNTT+ACFVAILIGLCLTL+ LAIF+KALPALPISITFGL+FYF T  ++ PFMD+++  Q YI
Sbjct:   74 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQ-LIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAMDYITVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPNGPLRLLVETAQERNETLFPALIYSSTMVW-LVNMAEGDPEAQRKVSKNSNYNAQSTGESQDSVTESDDGGFSEEWEAQRDSRLGPHHSTAESRSAVQDLSRSIPATEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 467          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:psen1 "Presenilin-1" species:8355 "Xenopus laevis" [GO:0005739 "mitochondrion" evidence=ISS] [GO:0005783 "endoplasmic reticulum" evidence=ISS] [GO:0005794 "Golgi apparatus" evidence=ISS] [GO:0005887 "integral component of plasma membrane" evidence=ISS] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=ISS] [GO:0016485 "protein processing" evidence=ISS] [GO:0043085 "positive regulation of catalytic activity" evidence=ISS] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 SMART:SM00730 GO:GO:0005783 GO:GO:0005739 GO:GO:0005794 GO:GO:0043085 GO:GO:0000139 GO:GO:0005887 GO:GO:0005789 GO:GO:0035556 GO:GO:0004190 GO:GO:0007219 GO:GO:0006509 GO:GO:0016485 PANTHER:PTHR10202 MEROPS:A22.001 CTD:5663 HOVERGEN:HBG011375 KO:K04505 PANTHER:PTHR10202:SF7 EMBL:D84427 EMBL:BC077762 PIR:JC5390 RefSeq:NP_001084023.1 UniGene:Xl.55408 GeneID:399258 KEGG:xla:399258 Xenbase:XB-GENE-481920 Uniprot:O12976)

HSP 1 Score: 370.933 bits (951), Expect = 1.820e-123
Identity = 220/398 (55.28%), Postives = 283/398 (71.11%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADS------------------SSDPKRPNRRRDNQ-------RMAAESQXQELSPPPLQQ-------QQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT  DG  L+YTPF E +++ G  A N+  NA I+++VI VMT++L++ YKY+C  +IHGWL +SS +LLF FSYI+LGEV KTYN+ +DYITLA ++WNFGVVGM+ IHWK PLLLQQ+YLI ISAL+AL FIKYLP +TTW +LA IS++ L AVL+P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MAD                   ++ P+  +   D+             +Q   ++  P  +          PP E+ EE RG+KLGLGDFIFYS+LVGKAS+   GDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGL+FYF T  ++ PFMD+++  Q YI
Sbjct:   39 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRFDGQ-LIYTPFTEDTESVGQRALNSILNATIMISVIIVMTILLVVLYKYRCYKVIHGWLIISSLLLLFFFSYIYLGEVFKTYNVAVDYITLALLIWNFGVVGMICIHWKGPLLLQQAYLIMISALMALVFIKYLPEWTTWLILAVISVYDLVAVLSPKGPLRMLVETAQERNETLFPALIYSSTMIW-LVNMADGDPGLKQSASTKTYNTQAPTAHPRSDSAASDDNGGFDTTWEDHRNAQIGPINSTPESRVAVQALPSNSPPSEDPEE-RGVKLGLGDFIFYSVLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 433          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:PSEN2 "Presenilin-2" species:9031 "Gallus gallus" [GO:0000139 "Golgi membrane" evidence=IEA] [GO:0004175 "endopeptidase activity" evidence=IBA] [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0005634 "nucleus" evidence=IBA] [GO:0005743 "mitochondrial inner membrane" evidence=IBA] [GO:0005765 "lysosomal membrane" evidence=IBA] [GO:0005789 "endoplasmic reticulum membrane" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IBA] [GO:0005938 "cell cortex" evidence=IBA] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=IBA] [GO:0006816 "calcium ion transport" evidence=IBA] [GO:0007219 "Notch signaling pathway" evidence=IEA] [GO:0007220 "Notch receptor processing" evidence=IBA] [GO:0009986 "cell surface" evidence=IBA] [GO:0016324 "apical plasma membrane" evidence=IBA] [GO:0030018 "Z disc" evidence=IBA] [GO:0030424 "axon" evidence=IBA] [GO:0030426 "growth cone" evidence=IBA] [GO:0031594 "neuromuscular junction" evidence=IBA] [GO:0035253 "ciliary rootlet" evidence=IBA] [GO:0035556 "intracellular signal transduction" evidence=IEA] [GO:0042987 "amyloid precursor protein catabolic process" evidence=IBA] [GO:0043025 "neuronal cell body" evidence=IBA] [GO:0043198 "dendritic shaft" evidence=IBA] [GO:0045121 "membrane raft" evidence=IBA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IBA] [GO:0050435 "beta-amyloid metabolic process" evidence=IBA] InterPro:IPR001108 InterPro:IPR001493 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01074 SMART:SM00730 GO:GO:0005938 GO:GO:0005634 GO:GO:0048471 GO:GO:0030424 GO:GO:0009986 GO:GO:0000139 GO:GO:0005887 GO:GO:0030018 GO:GO:0045121 GO:GO:0005765 GO:GO:0005743 GO:GO:0005789 GO:GO:0035556 GO:GO:0016324 GO:GO:0043198 GO:GO:0043025 GO:GO:0004190 GO:GO:0035253 GO:GO:0031594 GO:GO:0007219 GO:GO:0042987 GO:GO:0030426 GO:GO:0004175 GO:GO:0006816 GO:GO:0050435 GO:GO:0006509 GO:GO:0007220 PANTHER:PTHR10202 eggNOG:NOG237920 HOGENOM:HOG000240228 HOVERGEN:HBG011375 MEROPS:A22.002 CTD:5664 KO:K04522 EMBL:AY043493 RefSeq:NP_989633.1 UniGene:Gga.2719 PaxDb:Q90X07 GeneID:374188 KEGG:gga:374188 InParanoid:Q90X07 NextBio:20813693 PRO:PR:Q90X07 Uniprot:Q90X07)

HSP 1 Score: 371.318 bits (952), Expect = 2.060e-123
Identity = 211/362 (58.29%), Postives = 263/362 (72.65%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRR-------RDNQRMAAESQXQEL---SPPPLQQQQQPPVE---EEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEII 375
             +GAK+VIMLF PVTLCM  VV TI SV  YTE++G  L+YTPF E + + G    N+  N  I+++VI VMTV L++ YKY+C   IHGWL LSSFMLLFLF+YI+LGEVLKTYN+ MDY T+  I+WNFG VGM+ IHWK PL LQQ+YLI ISAL+ L FIKYLP ++ W +L  IS++ L AVL P GPLR+L ETAQERN+PIFP+LIYS+ ++++V GMA   +  K  +++       R+N    + S  Q L   SP P       P+     EEE+RG+KLGLGDFIFYS+LVGKA++   GDWNTTLA  VAILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  ++
Sbjct:   88 KYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFSEDTPSVGQRLLNSVLNTIIMISVIVVMTVFLVVLYKYRCYKFIHGWLILSSFMLLFLFTYIYLGEVLKTYNVAMDYPTVILIIWNFGAVGMIRIHWKGPLQLQQAYLIMISALMVLVFIKYLPEWSAWVILGAISIYDLIAVLCPKGPLRMLXETAQERNQPIFPALIYSSAMIWTV-GMAKPDTAAKGQSQQAWDAEDERENHSSTSHSDSQILDTRSPAPSH-----PITLEEMEEEERGVKLGLGDFIFYSVLVGKAAATPSGDWNTTLAXXVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLV 442          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:PSEN1 "Presenilin-1" species:9606 "Homo sapiens" [GO:0000045 "autophagic vacuole assembly" evidence=IEA] [GO:0000122 "negative regulation of transcription from RNA polymerase II promoter" evidence=IEA] [GO:0000139 "Golgi membrane" evidence=IEA] [GO:0000186 "activation of MAPKK activity" evidence=IEA] [GO:0000776 "kinetochore" evidence=IDA] [GO:0001568 "blood vessel development" evidence=IEA] [GO:0001708 "cell fate specification" evidence=IEA] [GO:0001756 "somitogenesis" evidence=IEA] [GO:0001764 "neuron migration" evidence=IEA] [GO:0001921 "positive regulation of receptor recycling" evidence=IEA] [GO:0001947 "heart looping" evidence=IEA] [GO:0002244 "hematopoietic progenitor cell differentiation" evidence=IEA] [GO:0002286 "T cell activation involved in immune response" evidence=IEA] [GO:0002573 "myeloid leukocyte differentiation" evidence=IEA] [GO:0004175 "endopeptidase activity" evidence=IDA] [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0005262 "calcium channel activity" evidence=IMP] [GO:0005515 "protein binding" evidence=IPI] [GO:0005640 "nuclear outer membrane" evidence=IDA] [GO:0005739 "mitochondrion" evidence=IDA] [GO:0005743 "mitochondrial inner membrane" evidence=IBA] [GO:0005765 "lysosomal membrane" evidence=IBA] [GO:0005783 "endoplasmic reticulum" evidence=IDA] [GO:0005789 "endoplasmic reticulum membrane" evidence=IEA] [GO:0005790 "smooth endoplasmic reticulum" evidence=IDA] [GO:0005791 "rough endoplasmic reticulum" evidence=IDA] [GO:0005794 "Golgi apparatus" evidence=IDA] [GO:0005813 "centrosome" evidence=IDA] [GO:0005887 "integral component of plasma membrane" evidence=IDA] [GO:0005938 "cell cortex" evidence=IBA] [GO:0006486 "protein glycosylation" evidence=IEA] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=IDA] [GO:0006816 "calcium ion transport" evidence=IBA] [GO:0006839 "mitochondrial transport" evidence=IEA] [GO:0006974 "cellular response to DNA damage stimulus" evidence=IEA] [GO:0006979 "response to oxidative stress" evidence=IEA] [GO:0007175 "negative regulation of epidermal growth factor-activated receptor activity" evidence=IEA] [GO:0007219 "Notch signaling pathway" evidence=IEA] [GO:0007220 "Notch receptor processing" evidence=IBA;TAS] [GO:0007613 "memory" evidence=IEA] [GO:0008013 "beta-catenin binding" evidence=IPI] [GO:0009791 "post-embryonic development" evidence=IEA] [GO:0009986 "cell surface" evidence=IBA] [GO:0015031 "protein transport" evidence=IEA] [GO:0015813 "L-glutamate transport" evidence=IEA] [GO:0015871 "choline transport" evidence=IEA] [GO:0016020 "membrane" evidence=IDA] [GO:0016021 "integral component of membrane" evidence=TAS] [GO:0016080 "synaptic vesicle targeting" evidence=IEA] [GO:0016324 "apical plasma membrane" evidence=IBA] [GO:0016337 "cell-cell adhesion" evidence=IMP] [GO:0016485 "protein processing" evidence=IDA] [GO:0021795 "cerebral cortex cell migration" evidence=IEA] [GO:0021870 "Cajal-Retzius cell differentiation" evidence=IEA] [GO:0021904 "dorsal/ventral neural tube patterning" evidence=IEA] [GO:0022617 "extracellular matrix disassembly" evidence=TAS] [GO:0030018 "Z disc" evidence=IBA] [GO:0030165 "PDZ domain binding" evidence=IPI] [GO:0030198 "extracellular matrix organization" evidence=TAS] [GO:0030326 "embryonic limb morphogenesis" evidence=IEA] [GO:0030424 "axon" evidence=IBA] [GO:0030426 "growth cone" evidence=IBA] [GO:0031410 "cytoplasmic vesicle" evidence=IEA] [GO:0031594 "neuromuscular junction" evidence=IBA] [GO:0031965 "nuclear membrane" evidence=IDA] [GO:0032436 "positive regulation of proteasomal ubiquitin-dependent protein catabolic process" evidence=IEA] [GO:0032469 "endoplasmic reticulum calcium ion homeostasis" evidence=IGI;IDA] [GO:0034205 "beta-amyloid formation" evidence=IEA] [GO:0035253 "ciliary rootlet" evidence=IBA] [GO:0035556 "intracellular signal transduction" evidence=IEA] [GO:0042325 "regulation of phosphorylation" evidence=IDA] [GO:0042640 "anagen" evidence=IEA] [GO:0042987 "amyloid precursor protein catabolic process" evidence=IBA;TAS] [GO:0043025 "neuronal cell body" evidence=IBA] [GO:0043065 "positive regulation of apoptotic process" evidence=IEA] [GO:0043066 "negative regulation of apoptotic process" evidence=IDA] [GO:0043085 "positive regulation of catalytic activity" evidence=IDA] [GO:0043198 "dendritic shaft" evidence=IBA] [GO:0043393 "regulation of protein binding" evidence=IEA] [GO:0043406 "positive regulation of MAP kinase activity" evidence=IEA] [GO:0043524 "negative regulation of neuron apoptotic process" evidence=IEA] [GO:0043589 "skin morphogenesis" evidence=IEA] [GO:0045121 "membrane raft" evidence=IBA] [GO:0045296 "cadherin binding" evidence=IBA] [GO:0048167 "regulation of synaptic plasticity" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IBA] [GO:0048538 "thymus development" evidence=IEA] [GO:0048666 "neuron development" evidence=IEA] [GO:0048705 "skeletal system morphogenesis" evidence=IEA] [GO:0048854 "brain morphogenesis" evidence=IEA] [GO:0050435 "beta-amyloid metabolic process" evidence=IBA] [GO:0050673 "epithelial cell proliferation" evidence=IEA] [GO:0050771 "negative regulation of axonogenesis" evidence=IEA] [GO:0050820 "positive regulation of coagulation" evidence=IEA] [GO:0050852 "T cell receptor signaling pathway" evidence=IEA] [GO:0051402 "neuron apoptotic process" evidence=IEA] [GO:0051444 "negative regulation of ubiquitin-protein ligase activity" evidence=IEA] [GO:0051563 "smooth endoplasmic reticulum calcium ion homeostasis" evidence=IBA] [GO:0051966 "regulation of synaptic transmission, glutamatergic" evidence=IEA] [GO:0060075 "regulation of resting membrane potential" evidence=IEA] [GO:0070588 "calcium ion transmembrane transport" evidence=IMP] [GO:0070765 "gamma-secretase complex" evidence=IDA] [GO:2000059 "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" evidence=IEA] [GO:2001234 "negative regulation of apoptotic signaling pathway" evidence=IEA] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01073 SMART:SM00730 Reactome:REACT_118779 GO:GO:0005938 GO:GO:0001708 GO:GO:0005794 GO:GO:0048471 GO:GO:0043085 GO:GO:0000186 GO:GO:0001764 GO:GO:0030424 GO:GO:0048167 GO:GO:0043066 GO:GO:0009986 GO:GO:0000139 GO:GO:0005887 GO:GO:0006979 GO:GO:0042325 GO:GO:0030018 GO:GO:0000776 EMBL:CH471061 GO:GO:0005813 GO:GO:0045121 GO:GO:0005765 GO:GO:0050852 GO:GO:0005743 GO:GO:0005789 GO:GO:0035556 GO:GO:0015031 GO:GO:0016324 GO:GO:0043198 GO:GO:0043025 GO:GO:0007613 GO:GO:0043406 GO:GO:0005262 GO:GO:0005791 GO:GO:0004190 GO:GO:0000045 GO:GO:0006486 GO:GO:0035253 GO:GO:0031410 GO:GO:0031594 GO:GO:0051402 GO:GO:0043393 GO:GO:0051563 GO:GO:0007219 Orphanet:1020 GO:GO:0043524 GO:GO:0006974 GO:GO:0043065 Orphanet:154 GO:GO:0042987 GO:GO:0000122 GO:GO:0030426 GO:GO:0001756 GO:GO:0009791 GO:GO:0030326 GO:GO:0004175 GO:GO:0048666 GO:GO:0050435 GO:GO:0016337 GO:GO:0006509 GO:GO:0007220 GO:GO:0048538 GO:GO:0006839 GO:GO:0001568 GO:GO:0001921 GO:GO:0001947 GO:GO:0005640 GO:GO:0042640 GO:GO:0032436 GO:GO:0016485 GO:GO:0045296 GO:GO:0048705 ChEMBL:CHEMBL2094135 GO:GO:0070765 GO:GO:0050771 GO:GO:0051444 GO:GO:2001234 GO:GO:0048854 GO:GO:0021904 GO:GO:0005790 GO:GO:0007175 GO:GO:0002286 GO:GO:0043589 GO:GO:0050673 Orphanet:275864 Orphanet:100070 Orphanet:100069 GO:GO:0002244 GO:GO:0051966 GO:GO:0060075 GO:GO:0016080 GO:GO:0021795 GO:GO:0015813 GO:GO:2000059 GO:GO:0034205 GO:GO:0002573 PANTHER:PTHR10202 Orphanet:387 EMBL:AF109907 GO:GO:0050820 MEROPS:A22.001 CTD:5663 eggNOG:NOG237920 HOVERGEN:HBG011375 KO:K04505 OMA:EAQRKVS TreeFam:TF315040 GO:GO:0021870 GO:GO:0015871 PANTHER:PTHR10202:SF7 EMBL:L42110 EMBL:L76517 EMBL:L76528 EMBL:L76519 EMBL:L76520 EMBL:L76521 EMBL:L76522 EMBL:L76523 EMBL:L76524 EMBL:L76525 EMBL:L76526 EMBL:L76527 EMBL:U40379 EMBL:U40380 EMBL:AJ008005 EMBL:AF416717 EMBL:AK312531 EMBL:AC004858 EMBL:BC011729 EMBL:D84149 PIR:S58396 PIR:S63683 PIR:S63684 RefSeq:NP_000012.1 RefSeq:NP_015557.2 RefSeq:XP_005267921.1 RefSeq:XP_005267922.1 RefSeq:XP_005267923.1 RefSeq:XP_005267924.1 UniGene:Hs.3260 PDB:2KR6 PDBsum:2KR6 ProteinModelPortal:P49768 SMR:P49768 BioGrid:111642 DIP:DIP-1134N IntAct:P49768 MINT:MINT-88325 STRING:9606.ENSP00000326366 BindingDB:P49768 GuidetoPHARMACOLOGY:2402 TCDB:1.A.54.1.1 PhosphoSite:P49768 DMDM:1709856 PaxDb:P49768 PRIDE:P49768 DNASU:5663 Ensembl:ENST00000261970 Ensembl:ENST00000324501 Ensembl:ENST00000344094 Ensembl:ENST00000357710 Ensembl:ENST00000394157 Ensembl:ENST00000394164 Ensembl:ENST00000553855 Ensembl:ENST00000555386 Ensembl:ENST00000557511 GeneID:5663 KEGG:hsa:5663 UCSC:uc001xnq.4 UCSC:uc001xnr.3 UCSC:uc001xnv.3 GeneCards:GC14P073603 HGNC:HGNC:9508 HPA:CAB006844 HPA:HPA030760 MIM:104311 MIM:600274 MIM:607822 MIM:613694 MIM:613737 neXtProt:NX_P49768 PharmGKB:PA33855 InParanoid:P49768 PhylomeDB:P49768 SignaLink:P49768 ChiTaRS:PSEN1 EvolutionaryTrace:P49768 GeneWiki:PSEN1 GenomeRNAi:5663 NextBio:22006 PMAP-CutDB:P49768 PRO:PR:P49768 ArrayExpress:P49768 Bgee:P49768 CleanEx:HS_PSEN1 Genevestigator:P49768 Uniprot:P49768)

HSP 1 Score: 372.089 bits (954), Expect = 2.064e-123
Identity = 217/399 (54.39%), Postives = 282/399 (70.68%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQRMAAESQXQE------------------------LSPPPLQQQQQPPVEE---------EEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT +DG  L+YTPF E ++  G  A ++  NA I+++VI VMT++L++ YKY+C  +IH WL +SS +LLF FS+I+LGEV KTYN+ +DYIT+A ++WNFGVVGM+SIHWK PL LQQ+YLI ISAL+AL FIKYLP +T W +LA IS++ L AVL P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MA+   DP+   R   N +  AES  +E                        L P     + +  V+E         + E+RG+KLGLGDFIFYS+LVGKAS+   GDWNTT+ACFVAILIGLCLTL+ LAIF+KALPALPISITFGL+FYF T  ++ PFMD+++  Q YI
Sbjct:   73 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQ-LIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEG--DPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI 467          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:PSEN1 "PSEN1 protein" species:9913 "Bos taurus" [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0035556 "intracellular signal transduction" evidence=IEA] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01073 SMART:SM00730 GO:GO:0016021 GO:GO:0008152 GO:GO:0035556 GO:GO:0004190 GeneTree:ENSGT00390000016593 PANTHER:PTHR10202 UniGene:Bt.51581 GeneID:282705 KEGG:bta:282705 CTD:5663 HOGENOM:HOG000240228 HOVERGEN:HBG011375 KO:K04505 PANTHER:PTHR10202:SF7 OrthoDB:EOG7NGQBG EMBL:DAAA02029591 EMBL:DAAA02029592 EMBL:DAAA02029593 EMBL:BC151458 RefSeq:XP_005211993.1 STRING:9913.ENSBTAP00000040765 Ensembl:ENSBTAT00000015615 ArrayExpress:A7MBA9 Uniprot:A7MBA9)

HSP 1 Score: 371.703 bits (953), Expect = 2.730e-123
Identity = 212/397 (53.40%), Postives = 280/397 (70.53%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDN---QRMAAESQX-------------------QELSPPPLQQQQQPPVE---------EEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT +DG  L+YTPF E ++     A ++  NA I+++VI +MT++L++ YKY+C  +IH WL +SS +LLF FS+I+LGEV KTYN+ MDYI++A ++WNFGVVGM++IHWK PL LQQ+YLI ISAL+AL FIKYLP +T W +LA IS++ L AVL P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MA+   + +R   +  N   Q   +ESQ                      L P     + +  V+         E+ E+RG+KLGLGDFIFYS+LVGKAS+   GDWNTT+ACFVAILIGLCLTL+ LAIF+KALPALP+SITFGLIFYF T  ++ PFMD+++  Q YI
Sbjct:   74 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQ-LIYTPFTEDTETVAQRALHSILNAVIMISVIVIMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAMDYISVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEGDPEAQRKVSKNSNYNAQSTESESQDPVTESDDGGFSEEWEAQRDSRLGPHHSTAESRSAVQDLSSSILASEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPVSITFGLIFYFATDYLVQPFMDQLAFHQFYI 468          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:Psen1 "Presenilin-1" species:10116 "Rattus norvegicus" [GO:0000045 "autophagic vacuole assembly" evidence=IEA] [GO:0000122 "negative regulation of transcription from RNA polymerase II promoter" evidence=IEA] [GO:0000139 "Golgi membrane" evidence=IEA] [GO:0000186 "activation of MAPKK activity" evidence=IEA] [GO:0000776 "kinetochore" evidence=IEA] [GO:0001568 "blood vessel development" evidence=IEA] [GO:0001708 "cell fate specification" evidence=IEA] [GO:0001756 "somitogenesis" evidence=IEA] [GO:0001764 "neuron migration" evidence=IEA] [GO:0001921 "positive regulation of receptor recycling" evidence=IEA] [GO:0001947 "heart looping" evidence=IEA] [GO:0002244 "hematopoietic progenitor cell differentiation" evidence=IEA] [GO:0002286 "T cell activation involved in immune response" evidence=IEA] [GO:0002573 "myeloid leukocyte differentiation" evidence=IEA] [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0005262 "calcium channel activity" evidence=IEA] [GO:0005515 "protein binding" evidence=IPI] [GO:0005634 "nucleus" evidence=IBA] [GO:0005640 "nuclear outer membrane" evidence=IEA] [GO:0005739 "mitochondrion" evidence=ISS] [GO:0005783 "endoplasmic reticulum" evidence=ISS;IBA] [GO:0005789 "endoplasmic reticulum membrane" evidence=IEA] [GO:0005790 "smooth endoplasmic reticulum" evidence=IEA] [GO:0005791 "rough endoplasmic reticulum" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=ISS] [GO:0005813 "centrosome" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=ISS;IBA] [GO:0005938 "cell cortex" evidence=IBA] [GO:0006486 "protein glycosylation" evidence=IEA] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=ISS] [GO:0006816 "calcium ion transport" evidence=IBA] [GO:0006839 "mitochondrial transport" evidence=IEA] [GO:0006974 "cellular response to DNA damage stimulus" evidence=IEA] [GO:0006979 "response to oxidative stress" evidence=IEA] [GO:0007175 "negative regulation of epidermal growth factor-activated receptor activity" evidence=IEA] [GO:0007219 "Notch signaling pathway" evidence=IEA] [GO:0007220 "Notch receptor processing" evidence=IBA] [GO:0007613 "memory" evidence=IEA] [GO:0008013 "beta-catenin binding" evidence=IEA] [GO:0009791 "post-embryonic development" evidence=IEA] [GO:0015031 "protein transport" evidence=IEA] [GO:0015813 "L-glutamate transport" evidence=IEA] [GO:0015871 "choline transport" evidence=IEA] [GO:0016080 "synaptic vesicle targeting" evidence=IEA] [GO:0016324 "apical plasma membrane" evidence=IBA] [GO:0016337 "cell-cell adhesion" evidence=IEA] [GO:0016485 "protein processing" evidence=ISS] [GO:0021795 "cerebral cortex cell migration" evidence=IEA] [GO:0021870 "Cajal-Retzius cell differentiation" evidence=IEA] [GO:0021904 "dorsal/ventral neural tube patterning" evidence=IEA] [GO:0030018 "Z disc" evidence=IBA] [GO:0030165 "PDZ domain binding" evidence=IEA] [GO:0030326 "embryonic limb morphogenesis" evidence=IEA] [GO:0030424 "axon" evidence=IBA] [GO:0030426 "growth cone" evidence=IBA] [GO:0031410 "cytoplasmic vesicle" evidence=IEA] [GO:0032436 "positive regulation of proteasomal ubiquitin-dependent protein catabolic process" evidence=IEA] [GO:0034205 "beta-amyloid formation" evidence=IEA] [GO:0035253 "ciliary rootlet" evidence=IBA] [GO:0035556 "intracellular signal transduction" evidence=IEA] [GO:0042640 "anagen" evidence=IEA] [GO:0042987 "amyloid precursor protein catabolic process" evidence=IBA] [GO:0043025 "neuronal cell body" evidence=IBA] [GO:0043065 "positive regulation of apoptotic process" evidence=IEA] [GO:0043085 "positive regulation of catalytic activity" evidence=ISS] [GO:0043198 "dendritic shaft" evidence=IBA] [GO:0043393 "regulation of protein binding" evidence=IEA] [GO:0043406 "positive regulation of MAP kinase activity" evidence=IEA] [GO:0043589 "skin morphogenesis" evidence=IEA] [GO:0045296 "cadherin binding" evidence=IBA] [GO:0048167 "regulation of synaptic plasticity" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IBA] [GO:0048538 "thymus development" evidence=IEA] [GO:0048705 "skeletal system morphogenesis" evidence=IEA] [GO:0048854 "brain morphogenesis" evidence=IEA] [GO:0050435 "beta-amyloid metabolic process" evidence=IBA] [GO:0050673 "epithelial cell proliferation" evidence=IEA] [GO:0050771 "negative regulation of axonogenesis" evidence=IEA] [GO:0050820 "positive regulation of coagulation" evidence=IEA] [GO:0050852 "T cell receptor signaling pathway" evidence=IEA] [GO:0051402 "neuron apoptotic process" evidence=IEA] [GO:0051444 "negative regulation of ubiquitin-protein ligase activity" evidence=IEA] [GO:0051563 "smooth endoplasmic reticulum calcium ion homeostasis" evidence=IBA] [GO:0051966 "regulation of synaptic transmission, glutamatergic" evidence=IEA] [GO:0060075 "regulation of resting membrane potential" evidence=IEA] [GO:0070765 "gamma-secretase complex" evidence=IEA] [GO:2000059 "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" evidence=IEA] [GO:2001234 "negative regulation of apoptotic signaling pathway" evidence=IEA] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01073 SMART:SM00730 RGD:3425 GO:GO:0005783 GO:GO:0005938 GO:GO:0005634 GO:GO:0001708 GO:GO:0005794 GO:GO:0048471 GO:GO:0043085 GO:GO:0000186 GO:GO:0001764 GO:GO:0030424 GO:GO:0048167 GO:GO:0043234 GO:GO:0009986 GO:GO:0000139 GO:GO:0005887 GO:GO:0006979 GO:GO:0030018 GO:GO:0000776 GO:GO:0005813 GO:GO:0045121 GO:GO:0005765 GO:GO:0050852 GO:GO:0005743 GO:GO:0005789 GO:GO:0035556 GO:GO:0015031 GO:GO:0016324 GO:GO:0043198 GO:GO:0043025 GO:GO:0007613 GO:GO:0043406 GO:GO:0005262 GO:GO:0005791 GO:GO:0004190 GO:GO:0000045 GO:GO:0006486 GO:GO:0035253 GO:GO:0031410 GO:GO:0031594 GO:GO:0051402 GO:GO:0043393 GO:GO:0051563 GO:GO:0007219 GO:GO:0043524 GO:GO:0006974 GO:GO:0043065 GO:GO:0042987 GO:GO:0000122 GO:GO:0030426 GO:GO:0001756 GO:GO:0009791 GO:GO:0030326 GO:GO:0004175 GO:GO:0006816 GO:GO:0050435 GO:GO:0016337 GO:GO:0006509 GO:GO:0007220 GO:GO:0048538 GO:GO:0006839 GO:GO:0001568 GO:GO:0001921 GO:GO:0001947 GO:GO:0005640 GO:GO:0042640 GO:GO:0032436 GO:GO:0016485 GO:GO:0045296 GO:GO:0048705 GO:GO:0070765 GO:GO:0050771 GO:GO:0051444 GO:GO:2001234 GO:GO:0048854 GO:GO:0021904 GO:GO:0005790 GO:GO:0007175 GO:GO:0002286 GO:GO:0043589 GO:GO:0042462 GO:GO:0050673 GO:GO:0002244 GO:GO:0051966 GO:GO:0060075 GO:GO:0016080 GO:GO:0021795 GO:GO:0015813 GO:GO:2000059 GO:GO:0034205 GO:GO:0002573 GeneTree:ENSGT00390000016593 PANTHER:PTHR10202 GO:GO:0050820 MEROPS:A22.001 CTD:5663 eggNOG:NOG237920 HOGENOM:HOG000240228 HOVERGEN:HBG011375 KO:K04505 OMA:EAQRKVS TreeFam:TF315040 GO:GO:0021870 GO:GO:0015871 PANTHER:PTHR10202:SF7 OrthoDB:EOG7NGQBG EMBL:D82363 EMBL:D82578 EMBL:BC070887 RefSeq:NP_062036.2 RefSeq:XP_006240383.1 RefSeq:XP_006240384.1 UniGene:Rn.44440 DIP:DIP-48909N IntAct:P97887 MINT:MINT-4567301 PhosphoSite:P97887 PRIDE:P97887 Ensembl:ENSRNOT00000012495 GeneID:29192 KEGG:rno:29192 UCSC:RGD:3425 InParanoid:P97887 NextBio:608323 PRO:PR:P97887 Genevestigator:P97887 Uniprot:P97887)

HSP 1 Score: 371.703 bits (953), Expect = 3.353e-123
Identity = 215/398 (54.02%), Postives = 280/398 (70.35%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD-----PKRPN------RRRDNQRMAAES------------QXQELSPPPLQQQQQPPVE---------EEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT +DG  L+YTPF E ++  G  A ++  NA I+++VI VMT++L++ YKY+C  +IH WL +SS +LLF FS+I+LGEV KTYN+ +DYIT+A ++WNFGVVGM++IHWK PL LQQ+YLI ISAL+AL FIKYLP +T W +LA IS++ L AVL P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MA+   +     PK P        R + Q     S            +   L P     + +  V+         E+ E+RG+KLGLGDFIFYS+LVGKAS+   GDWNTT+ACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF T  ++ PFMD+++  Q YI
Sbjct:   73 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQ-LIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEGDPEAQRRVPKNPKYSTQGTEREETQDTGTGSDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSGSILTSEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATDYLVQPFMDQLAFHQFYI 468          

BLAST of EMLSAG00000000448 vs. GO
Match: - (symbol:Psen1 "presenilin 1" species:10116 "Rattus norvegicus" [GO:0000045 "autophagic vacuole assembly" evidence=IEA;ISO] [GO:0000122 "negative regulation of transcription from RNA polymerase II promoter" evidence=IEA;ISO] [GO:0000139 "Golgi membrane" evidence=IEA] [GO:0000186 "activation of MAPKK activity" evidence=IEA;ISO] [GO:0000776 "kinetochore" evidence=IEA;ISO] [GO:0001568 "blood vessel development" evidence=IEA;ISO] [GO:0001708 "cell fate specification" evidence=IEA;ISO] [GO:0001756 "somitogenesis" evidence=IEA;ISO] [GO:0001764 "neuron migration" evidence=IEA;ISO] [GO:0001921 "positive regulation of receptor recycling" evidence=IEA;ISO] [GO:0001933 "negative regulation of protein phosphorylation" evidence=ISO] [GO:0001934 "positive regulation of protein phosphorylation" evidence=ISO] [GO:0001947 "heart looping" evidence=IEA;ISO] [GO:0002244 "hematopoietic progenitor cell differentiation" evidence=IEA;ISO] [GO:0002286 "T cell activation involved in immune response" evidence=IEA;ISO] [GO:0002573 "myeloid leukocyte differentiation" evidence=IEA;ISO] [GO:0004175 "endopeptidase activity" evidence=ISO;IDA] [GO:0004190 "aspartic-type endopeptidase activity" evidence=IEA] [GO:0005262 "calcium channel activity" evidence=IEA;ISO] [GO:0005515 "protein binding" evidence=IPI] [GO:0005622 "intracellular" evidence=ISO] [GO:0005623 "cell" evidence=ISO] [GO:0005634 "nucleus" evidence=ISO;IBA] [GO:0005640 "nuclear outer membrane" evidence=IEA;ISO] [GO:0005739 "mitochondrion" evidence=ISO;ISS;IDA] [GO:0005743 "mitochondrial inner membrane" evidence=IDA] [GO:0005765 "lysosomal membrane" evidence=IDA] [GO:0005783 "endoplasmic reticulum" evidence=ISO;ISS;IBA] [GO:0005789 "endoplasmic reticulum membrane" evidence=IEA] [GO:0005790 "smooth endoplasmic reticulum" evidence=IEA;ISO] [GO:0005791 "rough endoplasmic reticulum" evidence=IEA;ISO] [GO:0005794 "Golgi apparatus" evidence=ISO;ISS] [GO:0005813 "centrosome" evidence=IEA;ISO] [GO:0005886 "plasma membrane" evidence=ISO] [GO:0005887 "integral component of plasma membrane" evidence=ISO;ISS;IBA] [GO:0005938 "cell cortex" evidence=IBA] [GO:0006469 "negative regulation of protein kinase activity" evidence=ISO] [GO:0006486 "protein glycosylation" evidence=IEA;ISO] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=ISO;ISS;IMP] [GO:0006816 "calcium ion transport" evidence=IBA] [GO:0006839 "mitochondrial transport" evidence=IEA;ISO] [GO:0006874 "cellular calcium ion homeostasis" evidence=ISO] [GO:0006914 "autophagy" evidence=ISO] [GO:0006974 "cellular response to DNA damage stimulus" evidence=IEA;ISO] [GO:0006979 "response to oxidative stress" evidence=IEA;ISO] [GO:0007175 "negative regulation of epidermal growth factor-activated receptor activity" evidence=IEA;ISO] [GO:0007176 "regulation of epidermal growth factor-activated receptor activity" evidence=ISO] [GO:0007219 "Notch signaling pathway" evidence=IEA;ISO] [GO:0007220 "Notch receptor processing" evidence=ISO;IBA] [GO:0007420 "brain development" evidence=ISO] [GO:0007507 "heart development" evidence=ISO] [GO:0007611 "learning or memory" evidence=ISO] [GO:0007613 "memory" evidence=IEA;ISO] [GO:0008013 "beta-catenin binding" evidence=IEA;ISO] [GO:0008233 "peptidase activity" evidence=IDA] [GO:0009790 "embryo development" evidence=ISO] [GO:0009791 "post-embryonic development" evidence=IEA;ISO] [GO:0009986 "cell surface" evidence=IDA] [GO:0015031 "protein transport" evidence=IEA;ISO] [GO:0015813 "L-glutamate transport" evidence=IEA;ISO] [GO:0015871 "choline transport" evidence=IEA;ISO] [GO:0016020 "membrane" evidence=ISO] [GO:0016080 "synaptic vesicle targeting" evidence=IEA;ISO] [GO:0016324 "apical plasma membrane" evidence=IBA] [GO:0016337 "cell-cell adhesion" evidence=IEA;ISO] [GO:0016485 "protein processing" evidence=ISO;ISS;IDA] [GO:0021795 "cerebral cortex cell migration" evidence=IEA;ISO] [GO:0021870 "Cajal-Retzius cell differentiation" evidence=IEA;ISO] [GO:0021904 "dorsal/ventral neural tube patterning" evidence=IEA;ISO] [GO:0021987 "cerebral cortex development" evidence=ISO] [GO:0022008 "neurogenesis" evidence=ISO] [GO:0030018 "Z disc" evidence=IBA] [GO:0030165 "PDZ domain binding" evidence=IEA;ISO] [GO:0030182 "neuron differentiation" evidence=ISO] [GO:0030326 "embryonic limb morphogenesis" evidence=IEA;ISO] [GO:0030424 "axon" evidence=ISO;IBA] [GO:0030425 "dendrite" evidence=ISO] [GO:0030426 "growth cone" evidence=ISO;IBA] [GO:0030900 "forebrain development" evidence=ISO] [GO:0031410 "cytoplasmic vesicle" evidence=IEA;ISO] [GO:0031594 "neuromuscular junction" evidence=IDA] [GO:0031965 "nuclear membrane" evidence=ISO] [GO:0032436 "positive regulation of proteasomal ubiquitin-dependent protein catabolic process" evidence=IEA;ISO] [GO:0032469 "endoplasmic reticulum calcium ion homeostasis" evidence=ISO] [GO:0034205 "beta-amyloid formation" evidence=IEA;ISO] [GO:0035253 "ciliary rootlet" evidence=ISO;IBA] [GO:0035282 "segmentation" evidence=ISO] [GO:0035556 "intracellular signal transduction" evidence=IEA] [GO:0040011 "locomotion" evidence=ISO] [GO:0042325 "regulation of phosphorylation" evidence=ISO] [GO:0042462 "eye photoreceptor cell development" evidence=NAS] [GO:0042640 "anagen" evidence=IEA;ISO] [GO:0042987 "amyloid precursor protein catabolic process" evidence=ISO;IBA] [GO:0043005 "neuron projection" evidence=IDA] [GO:0043025 "neuronal cell body" evidence=ISO;IBA] [GO:0043065 "positive regulation of apoptotic process" evidence=IEA;ISO] [GO:0043066 "negative regulation of apoptotic process" evidence=ISO;IDA] [GO:0043085 "positive regulation of catalytic activity" evidence=ISO;ISS] [GO:0043198 "dendritic shaft" evidence=ISO;IBA] [GO:0043227 "membrane-bounded organelle" evidence=ISO] [GO:0043234 "protein complex" evidence=IDA] [GO:0043393 "regulation of protein binding" evidence=IEA;ISO] [GO:0043406 "positive regulation of MAP kinase activity" evidence=IEA;ISO] [GO:0043524 "negative regulation of neuron apoptotic process" evidence=IMP] [GO:0043589 "skin morphogenesis" evidence=IEA;ISO] [GO:0044267 "cellular protein metabolic process" evidence=ISO] [GO:0045121 "membrane raft" evidence=IDA] [GO:0045296 "cadherin binding" evidence=ISO;IBA] [GO:0045860 "positive regulation of protein kinase activity" evidence=ISO] [GO:0048167 "regulation of synaptic plasticity" evidence=IEA;ISO] [GO:0048471 "perinuclear region of cytoplasm" evidence=IBA] [GO:0048538 "thymus development" evidence=IEA;ISO] [GO:0048666 "neuron development" evidence=ISO] [GO:0048705 "skeletal system morphogenesis" evidence=IEA;ISO] [GO:0048854 "brain morphogenesis" evidence=IEA;ISO] [GO:0050435 "beta-amyloid metabolic process" evidence=ISO;IBA] [GO:0050673 "epithelial cell proliferation" evidence=IEA;ISO] [GO:0050771 "negative regulation of axonogenesis" evidence=IEA;ISO] [GO:0050820 "positive regulation of coagulation" evidence=IEA;ISO] [GO:0050852 "T cell receptor signaling pathway" evidence=IEA;ISO] [GO:0051402 "neuron apoptotic process" evidence=IEA;ISO] [GO:0051444 "negative regulation of ubiquitin-protein ligase activity" evidence=IEA;ISO] [GO:0051563 "smooth endoplasmic reticulum calcium ion homeostasis" evidence=ISO;IBA] [GO:0051604 "protein maturation" evidence=ISO] [GO:0051966 "regulation of synaptic transmission, glutamatergic" evidence=IEA;ISO] [GO:0060075 "regulation of resting membrane potential" evidence=IEA;ISO] [GO:0070588 "calcium ion transmembrane transport" evidence=ISO] [GO:0070765 "gamma-secretase complex" evidence=IEA;ISO] [GO:2000059 "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" evidence=IEA;ISO] [GO:2001234 "negative regulation of apoptotic signaling pathway" evidence=IEA;ISO] InterPro:IPR001108 InterPro:IPR002031 InterPro:IPR006639 Pfam:PF01080 PRINTS:PR01072 PRINTS:PR01073 SMART:SM00730 RGD:3425 GO:GO:0005783 GO:GO:0005938 GO:GO:0005634 GO:GO:0001708 GO:GO:0005794 GO:GO:0048471 GO:GO:0043085 GO:GO:0000186 GO:GO:0001764 GO:GO:0030424 GO:GO:0048167 GO:GO:0043234 GO:GO:0009986 GO:GO:0000139 GO:GO:0005887 GO:GO:0006979 GO:GO:0030018 GO:GO:0000776 GO:GO:0005813 GO:GO:0045121 GO:GO:0005765 GO:GO:0050852 GO:GO:0005743 GO:GO:0005789 GO:GO:0035556 GO:GO:0015031 GO:GO:0016324 GO:GO:0043198 GO:GO:0043025 GO:GO:0007613 GO:GO:0043406 GO:GO:0005262 GO:GO:0005791 GO:GO:0004190 GO:GO:0000045 GO:GO:0006486 GO:GO:0035253 GO:GO:0031410 GO:GO:0031594 GO:GO:0051402 GO:GO:0043393 GO:GO:0051563 GO:GO:0007219 GO:GO:0043524 GO:GO:0006974 GO:GO:0043065 GO:GO:0042987 GO:GO:0000122 GO:GO:0030426 GO:GO:0001756 GO:GO:0009791 GO:GO:0030326 GO:GO:0004175 GO:GO:0006816 GO:GO:0050435 GO:GO:0016337 GO:GO:0006509 GO:GO:0007220 GO:GO:0048538 GO:GO:0006839 GO:GO:0001568 GO:GO:0001921 GO:GO:0001947 GO:GO:0005640 GO:GO:0042640 GO:GO:0032436 GO:GO:0016485 GO:GO:0045296 GO:GO:0048705 GO:GO:0070765 GO:GO:0050771 GO:GO:0051444 GO:GO:2001234 GO:GO:0048854 GO:GO:0021904 GO:GO:0005790 GO:GO:0007175 GO:GO:0002286 GO:GO:0043589 GO:GO:0042462 GO:GO:0050673 GO:GO:0002244 GO:GO:0051966 GO:GO:0060075 GO:GO:0016080 GO:GO:0021795 GO:GO:0015813 GO:GO:2000059 GO:GO:0034205 GO:GO:0002573 GeneTree:ENSGT00390000016593 PANTHER:PTHR10202 GO:GO:0050820 MEROPS:A22.001 CTD:5663 eggNOG:NOG237920 HOGENOM:HOG000240228 HOVERGEN:HBG011375 KO:K04505 OMA:EAQRKVS TreeFam:TF315040 GO:GO:0021870 GO:GO:0015871 PANTHER:PTHR10202:SF7 OrthoDB:EOG7NGQBG EMBL:D82363 EMBL:D82578 EMBL:BC070887 RefSeq:NP_062036.2 RefSeq:XP_006240383.1 RefSeq:XP_006240384.1 UniGene:Rn.44440 DIP:DIP-48909N IntAct:P97887 MINT:MINT-4567301 PhosphoSite:P97887 PRIDE:P97887 Ensembl:ENSRNOT00000012495 GeneID:29192 KEGG:rno:29192 UCSC:RGD:3425 InParanoid:P97887 NextBio:608323 PRO:PR:P97887 Genevestigator:P97887 Uniprot:P97887)

HSP 1 Score: 371.703 bits (953), Expect = 3.353e-123
Identity = 215/398 (54.02%), Postives = 280/398 (70.35%), Query Frame = 0

Query:   26 FVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD-----PKRPN------RRRDNQRMAAES------------QXQELSPPPLQQQQQPPVE---------EEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              + +GAK+VIMLF PVTLCM  VV TI SV+ YT +DG  L+YTPF E ++  G  A ++  NA I+++VI VMT++L++ YKY+C  +IH WL +SS +LLF FS+I+LGEV KTYN+ +DYIT+A ++WNFGVVGM++IHWK PL LQQ+YLI ISAL+AL FIKYLP +T W +LA IS++ L AVL P GPLR+LVETAQERNE +FP+LIYS+ +++ ++ MA+   +     PK P        R + Q     S            +   L P     + +  V+         E+ E+RG+KLGLGDFIFYS+LVGKAS+   GDWNTT+ACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF T  ++ PFMD+++  Q YI
Sbjct:   73 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQ-LIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEGDPEAQRRVPKNPKYSTQGTEREETQDTGTGSDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSGSILTSEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATDYLVQPFMDQLAFHQFYI 468          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940342|gb|GAXK01018211.1| (TSA: Calanus finmarchicus comp33636_c1_seq2 transcribed RNA sequence)

HSP 1 Score: 442.58 bits (1137), Expect = 7.356e-151
Identity = 261/404 (64.60%), Postives = 311/404 (76.98%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWXXXXXXXXXXXXXXXXXGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYXXXXXXXXXXXXXKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD----PKRPNR---------------------------------------RRDNQRMAAXXXXXXXXXXXXXXXXXXXXXXXXXDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
             +GA +VI LF+PVT+CMA VV TI S+T YTE+ G YLVYTPFHE +++ GT+AW A ANAGI+L VIAVMT +L+++YKY+C+ LIHGWLF+SS MLLFLFSY++L EVLK YNLPMDYITLA ++WNFG+VGM+SI+WKAPLLLQQ+YLIFISAL+AL FIKYLP++TTWAVLA ISLW LFAVLAPFGPLRILVETAQERNE IFPSLIYS+G++Y+++GMAD+  +    P+R  R                                        R  QR A   +  +    P    +   VEEEEED+G+KLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTL+FLA+FR+ALPALPISITFGLIFYFLTKEI+TPF D +SS+QI+I
Sbjct:   17 KYGAHHVIKLFSPVTMCMAVVVATISSITYYTEK-GTYLVYTPFHEETEDVGTLAWQALANAGIMLGVIAVMTGLLVLAYKYRCTKLIHGWLFMSSLMLLFLFSYLYLAEVLKAYNLPMDYITLAIVIWNFGMVGMISIYWKAPLLLQQAYLIFISALMALIFIKYLPDWTTWAVLAVISLWDLFAVLAPFGPLRILVETAQERNEQIFPSLIYSSGMVYALVGMADTEGEAPVAPRRQGRTGSAGAEERAEGEVSAQTRPQGGEDARDGFSDTWVRENDERSRQRSA---RVSQTGAGPRSGVRTELVEEEEEDKGVKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLVFLALFRRALPALPISITFGLIFYFLTKEIVTPFCDALSSQQIFI 1216          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940343|gb|GAXK01018210.1| (TSA: Calanus finmarchicus comp33636_c1_seq1 transcribed RNA sequence)

HSP 1 Score: 443.736 bits (1140), Expect = 7.438e-151
Identity = 261/404 (64.60%), Postives = 311/404 (76.98%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWXXXXXXXXXXXXXXXXXGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYXXXXXXXXXXXXXKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD----PKRPNR---------------------------------------RRDNQRMAAXXXXXXXXXXXXXXXXXXXXXXXXXDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
             +GA +VI LF+PVT+CMA VV TI S+T YTE+ G YLVYTPFHE +++ GT+AW A ANAGI+L VIAVMT +L+++YKY+C+ LIHGWLF+SS MLLFLFSY++L EVLK YNLPMDYITLA ++WNFG+VGM+SI+WKAPLLLQQ+YLIFISAL+AL FIKYLP++TTWAVLA ISLW LFAVLAPFGPLRILVETAQERNE IFPSLIYS+G++Y+++GMAD+  +    P+R  R                                        R  QR A   +  +    P    +   VEEEEED+G+KLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTL+FLA+FR+ALPALPISITFGLIFYFLTKEI+TPF D +SS+QI+I
Sbjct:  122 KYGAHHVIKLFSPVTMCMAVVVATISSITYYTEK-GTYLVYTPFHEETEDVGTLAWQALANAGIMLGVIAVMTGLLVLAYKYRCTKLIHGWLFMSSLMLLFLFSYLYLAEVLKAYNLPMDYITLAIVIWNFGMVGMISIYWKAPLLLQQAYLIFISALMALIFIKYLPDWTTWAVLAVISLWDLFAVLAPFGPLRILVETAQERNEQIFPSLIYSSGMVYALVGMADTEGEAPVAPRRQGRTGSAGAEERAEGEVSAQTRPQGGEDARDGFSDTWVRENDERSRQRSA---RVSQTGAGPRSGVRTELVEEEEEDKGVKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLVFLALFRRALPALPISITFGLIFYFLTKEIVTPFCDALSSQQIFI 1321          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940341|gb|GAXK01018212.1| (TSA: Calanus finmarchicus comp33636_c1_seq3 transcribed RNA sequence)

HSP 1 Score: 388.652 bits (997), Expect = 1.911e-130
Identity = 233/361 (64.54%), Postives = 277/361 (76.73%), Query Frame = 0

Query:   72 FHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWXXXXXXXXXXXXXXXXXGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYXXXXXXXXXXXXXKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD----PKRPNR---------------------------------------RRDNQRMAAXXXXXXXXXXXXXXXXXXXXXXXXXDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            FHE +++ GT+AW A ANAGI+L VIAVMT +L+++YKY+C+ LIHGWLF+SS MLLFLFSY++L EVLK YNLPMDYITLA ++WNFG+VGM+SI+WKAPLLLQQ+YLIFISAL+AL FIKYLP++TTWAVLA ISLW LFAVLAPFGPLRILVETAQERNE IFPSLIYS+G++Y+++GMAD+  +    P+R  R                                        R  QR A   +  +    P    +   VEEEEED+G+KLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTL+FLA+FR+ALPALPISITFGLIFYFLTKEI+TPF D +SS+QI+I
Sbjct:    2 FHEETEDVGTLAWQALANAGIMLGVIAVMTGLLVLAYKYRCTKLIHGWLFMSSLMLLFLFSYLYLAEVLKAYNLPMDYITLAIVIWNFGMVGMISIYWKAPLLLQQAYLIFISALMALIFIKYLPDWTTWAVLAVISLWDLFAVLAPFGPLRILVETAQERNEQIFPSLIYSSGMVYALVGMADTEGEAPVAPRRQGRTGSAGAEERAEGEVSAQTRPQGGEDARDGFSDTWVRENDERSRQRSA---RVSQTGAGPRSGVRTELVEEEEEDKGVKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLVFLALFRRALPALPISITFGLIFYFLTKEIVTPFCDALSSQQIFI 1075          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940338|gb|GAXK01018215.1| (TSA: Calanus finmarchicus comp33636_c5_seq2 transcribed RNA sequence)

HSP 1 Score: 253.832 bits (647), Expect = 5.272e-81
Identity = 149/200 (74.50%), Postives = 177/200 (88.50%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWXXXXXXXXXXXXXXXXXGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYXXXXXXXXXXXXXKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVET 228
             +GA +VI LF+PVT+CMA VV TI S+T YTE+ G YLVYTPFHE +++ GT+AW A ANAGI+L VIAVMT +L+++YKY+C+ LIHGWLF+SS MLLFLFSY++L EVLK YNLPMDYITLA ++WNFG+VGM+SI+WKAPLLLQQSYLIFISAL+AL FIKYLP++TTWAVLA ISLW LFAVLAPFGPLRILVET
Sbjct:    1 KYGAHHVIKLFSPVTMCMAVVVATISSITYYTEK-GTYLVYTPFHEETEDVGTLAWQALANAGIMLGVIAVMTGLLVLAYKYRCTKLIHGWLFMSSLMLLFLFSYLYLAEVLKAYNLPMDYITLAIVIWNFGMVGMISIYWKAPLLLQQSYLIFISALMALIFIKYLPDWTTWAVLAVISLWDLFAVLAPFGPLRILVET 597          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940337|gb|GAXK01018216.1| (TSA: Calanus finmarchicus comp33636_c5_seq3 transcribed RNA sequence)

HSP 1 Score: 246.514 bits (628), Expect = 2.886e-78
Identity = 145/196 (73.98%), Postives = 173/196 (88.27%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWXXXXXXXXXXXXXXXXXGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYXXXXXXXXXXXXXKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRI 224
             +GA +VI LF+PVT+CMA VV TI S+T YTE+ G YLVYTPFHE +++ GT+AW A ANAGI+L VIAVMT +L+++YKY+C+ LIHGWLF+SS MLLFLFSY++L EVLK YNLPMDYITLA ++WNFG+VGM+SI+WKAPLLLQQSYLIFISAL+AL FIKYLP++TTWAVLA ISLW LFAVLAPFGPLRI
Sbjct:    1 KYGAHHVIKLFSPVTMCMAVVVATISSITYYTEK-GTYLVYTPFHEETEDVGTLAWQALANAGIMLGVIAVMTGLLVLAYKYRCTKLIHGWLFMSSLMLLFLFSYLYLAEVLKAYNLPMDYITLAIVIWNFGMVGMISIYWKAPLLLQQSYLIFISALMALIFIKYLPDWTTWAVLAVISLWDLFAVLAPFGPLRI 585          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940339|gb|GAXK01018214.1| (TSA: Calanus finmarchicus comp33636_c5_seq1 transcribed RNA sequence)

HSP 1 Score: 197.978 bits (502), Expect = 1.241e-58
Identity = 112/203 (55.17%), Postives = 135/203 (66.50%), Query Frame = 0

Query:  227 ETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD----PKRPN------------------------------------RRRDNQRMAAXXXXXXXXXXXXXXXXXXXXXXXXXDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            ETAQERNE IFPSLIYS+G++Y+++GMAD+  +    P+R                                      R  D +     ++  +    P    +   VEEEEED+G+KLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTL+FLA+FR+ALPALPISITFGLIFYFLTKEI+TPF D +SS+QI+I
Sbjct:  313 ETAQERNEQIFPSLIYSSGMVYALVGMADTEGEAPVAPRRQGRTGSAGAEERAEGEVSAQTRPQGGEDARDGFSDTWVRENDERSRQRSARVSQTGAGPRSGVRTELVEEEEEDKGVKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLVFLALFRRALPALPISITFGLIFYFLTKEIVTPFCDALSSQQIFI 921          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940340|gb|GAXK01018213.1| (TSA: Calanus finmarchicus comp33636_c1_seq4 transcribed RNA sequence)

HSP 1 Score: 170.629 bits (431), Expect = 1.099e-48
Identity = 79/90 (87.78%), Postives = 88/90 (97.78%), Query Frame = 0

Query:  300 DRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            D+G+KLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTL+FLA+FR+ALPALPISITFGLIFYFLTKEI+TPF D +SS+QI+I
Sbjct:  227 DKGVKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLVFLALFRRALPALPISITFGLIFYFLTKEIVTPFCDALSSQQIFI 496          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940336|gb|GAXK01018217.1| (TSA: Calanus finmarchicus comp33636_c5_seq4 transcribed RNA sequence)

HSP 1 Score: 150.599 bits (379), Expect = 4.042e-42
Identity = 72/81 (88.89%), Postives = 79/81 (97.53%), Query Frame = 0

Query:  309 DFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            DFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTL+FLA+FR+ALPALPISITFGLIFYFLTKEI+TPF D +SS+QI+I
Sbjct:  313 DFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLVFLALFRRALPALPISITFGLIFYFLTKEIVTPFCDALSSQQIFI 555          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592940335|gb|GAXK01018218.1| (TSA: Calanus finmarchicus comp33636_c5_seq5 transcribed RNA sequence)

HSP 1 Score: 127.872 bits (320), Expect = 2.957e-34
Identity = 58/91 (63.74%), Postives = 75/91 (82.42%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGW 119
             +GA +VI LF+PVT+CMA VV TI S+T YTE+ G YLVYTPFHE +++ GT+AW A ANAGI+L VIAVMT +L+++YKY+C+ LIHGW
Sbjct:   18 KYGAHHVIKLFSPVTMCMAVVVATISSITYYTEK-GTYLVYTPFHEETEDVGTLAWQALANAGIMLGVIAVMTGLLVLAYKYRCTKLIHGW 287          

BLAST of EMLSAG00000000448 vs. C. finmarchicus
Match: gi|592840001|gb|GAXK01117543.1| (TSA: Calanus finmarchicus comp607688_c1_seq2 transcribed RNA sequence)

HSP 1 Score: 40.0466 bits (92), Expect = 3.485e-3
Identity = 18/34 (52.94%), Postives = 26/34 (76.47%), Query Frame = 0

Query:   82 IAWNAFANAGILLAVIAVMTVILIISYKYKCSWL 115
            IA  A ANAGI+L VIAVM  +++++YK +C+ L
Sbjct:   86 IALQALANAGIVLGVIAVMMGLVVLAYKCRCTKL 187          

BLAST of EMLSAG00000000448 vs. L. salmonis peptides
Match: EMLSAP00000000448 (pep:novel supercontig:LSalAtl2s:LSalAtl2s106:189612:190849:-1 gene:EMLSAG00000000448 transcript:EMLSAT00000000448 description:"maker-LSalAtl2s106-augustus-gene-2.11")

HSP 1 Score: 778.474 bits (2009), Expect = 0.000e+0
Identity = 389/389 (100.00%), Postives = 389/389 (100.00%), Query Frame = 0

Query:    1 MSSEGEEVRIRDPRRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            MSSEGEEVRIRDPRRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI
Sbjct:    1 MSSEGEEVRIRDPRRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|37082570|sp|Q90ZE4.2|PSN2_DANRE (RecName: Full=Presenilin-2; Short=PS-2; Short=Zf-PS2; AltName: Full=Pre2)

HSP 1 Score: 425.631 bits (1093), Expect = 1.344e-146
Identity = 223/380 (58.68%), Postives = 283/380 (74.47%), Query Frame = 0

Query:   12 DPRRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEE-EEDRGIKLGLGDFIFYSILVGKASSY-GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            D  R +  + EEEE  + +GAK+VIMLF PVTLCM  VV TI SV+ YTE+ G  L+YTPF E  ++ G    N+  N  ++++VI  MT+IL++ YKY+C   IHGWL LSS MLLF FS+++LGEV KTYN+ MDY TL  I+WNFGVVGM+ IHWK PL LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ +++ ++GMADS++      RRR    +  +   +     P   ++Q   EE+ EEDRG+KLGLGDFIFYS+LVGKA++  GDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGL+FYF T  ++ PFMD +++ Q YI
Sbjct:   63 DRERADTPDGEEEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTEKSGQRLIYTPFEEDPNSVGQRLLNSVLNTLVMISVIVFMTIILVLLYKYRCYKFIHGWLILSSLMLLFWFSFMYLGEVFKTYNVAMDYPTLLMIIWNFGVVGMICIHWKGPLRLQQAYLIVISALMALIFIKYLPEWSAWVILGAISIYDLIAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW-MVGMADSNNPDSAGERRRSGGGVRTQEGVESEHDAPQAGRRQYSAEEDLEEDRGVKLGLGDFIFYSVLVGKAAATGGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFSTDNLVRPFMDSLAAHQYYI 441          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|6093851|sp|O12977.1|PSN2_XENLA (RecName: Full=Presenilin-2; Short=PS-2; AltName: Full=Presenilin beta; Short=PS-beta)

HSP 1 Score: 419.083 bits (1076), Expect = 7.949e-144
Identity = 219/367 (59.67%), Postives = 277/367 (75.48%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRR----RDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGK--ASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
             +GA++VIMLF PVTLCM  VV TI SV+ YTE+DG  L+YTPF E + + G    N+  N  I+++VI VMT+ L++ YKY+C   IHGWL LSS MLLF+F+YI+L EV KTYN+ MDY TL  ++WNFG VGM+ IHWK PL LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ +M++V GMADS++   R N++      N    A S  ++ +   +Q Q     E+ +E+RG+KLGLGDFIFYS+LVGK  A++ GDWNTTLACFVAILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  I+ PFMD ++S Q+YI
Sbjct:   85 KYGARHVIMLFVPVTLCMVVVVATIKSVSFYTEKDGQ-LIYTPFSEDTTSVGERLLNSVLNTLIMISVILVMTIFLVLLYKYRCYKFIHGWLILSSLMLLFMFTYIYLSEVFKTYNIAMDYPTLFMVIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLLAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMMWTV-GMADSATADGRMNQQVQHIDRNTPEGANSTVEDAAETRIQTQSNLSSEDPDEERGVKLGLGDFIFYSVLVGKAAATASGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNIVRPFMDTLASHQMYI 449          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|1709858|sp|P49810.1|PSN2_HUMAN (RecName: Full=Presenilin-2; Short=PS-2; AltName: Full=AD3LP; AltName: Full=AD5; AltName: Full=E5-1; AltName: Full=STM-2; Contains: RecName: Full=Presenilin-2 NTF subunit; Contains: RecName: Full=Presenilin-2 CTF subunit)

HSP 1 Score: 406.371 bits (1043), Expect = 7.540e-139
Identity = 233/403 (57.82%), Postives = 286/403 (70.97%), Query Frame = 0

Query:    2 SSEGEEVRIRDPRRREVQELE------EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA--DSSSD-----PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            S E EE    DP R     +       EEE  + +GAK+VIMLF PVTLCM  VV TI SV  YTE++G  L+YTPF E + + G    N+  N  I+++VI VMT+ L++ YKY+C   IHGWL +SS MLLFLF+YI+LGEVLKTYN+ MDY TL   +WNFG VGM+ IHWK PL+LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ ++++V GMA  D SS      P  P    D+     E    E+  PPL         EEEE+RG+KLGLGDFIFYS+LVGKA++   GDWNTTLACFVAILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  ++ PFMD ++S Q+YI
Sbjct:   49 SQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV-GMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPG-EELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|122143204|sp|Q0MS45.1|PSN2_PIG (RecName: Full=Presenilin-2; Short=PS-2; Contains: RecName: Full=Presenilin-2 NTF subunit; Contains: RecName: Full=Presenilin-2 CTF subunit)

HSP 1 Score: 404.06 bits (1037), Expect = 5.016e-138
Identity = 232/403 (57.57%), Postives = 285/403 (70.72%), Query Frame = 0

Query:    2 SSEGEEVRIRDPRRREVQELE------EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA--DSSSD-----PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            S + EE    DP R     +       EEE  + +GAK+VIMLF PVTLCM  VV TI SV  YTE++G  L+YTPF E + + G    N+  N  I+++VI VMT+ L++ YKY+C   IHGWL  SS MLLFLF+YI+LGEVLKTYN+ MDY TL   +WNFG VGM+ IHWK PL+LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ ++++V GMA  D SS      P  P    D+     E    E+  PPL         EEEE+RG+KLGLGDFIFYS+LVGKA++   GDWNTTLACFVAILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  ++ PFMD ++S Q+YI
Sbjct:   49 SQDSEEDHEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLITSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV-GMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLPGYPG-EELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|75042205|sp|Q5RCN9.1|PSN2_PONAB (RecName: Full=Presenilin-2; Short=PS-2; Contains: RecName: Full=Presenilin-2 NTF subunit; Contains: RecName: Full=Presenilin-2 CTF subunit)

HSP 1 Score: 404.06 bits (1037), Expect = 5.473e-138
Identity = 232/403 (57.57%), Postives = 285/403 (70.72%), Query Frame = 0

Query:    2 SSEGEEVRIRDPRRREVQELE------EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA--DSSSD-----PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            S E EE    DP R     +       EEE  + +GAK+VIMLF PVTLCM  VV TI SV  YTE++G  L+YTPF E + + G    N+  N  I+++VI  MT+ L++ YKY+C   IHGWL +SS MLLFLF+YI+LGEVLKTYN+ MDY TL   +WNFG VGM+ IHWK PL+LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ ++++V GMA  D SS      P  P    D+     E    E+  PPL         EEEE+RG+KLGLGDFIFYS+LVGKA++   GDWNTTLACFVAILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  ++ PFMD ++S Q+YI
Sbjct:   49 SQENEEDGEEDPDRYICSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVAMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV-GMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPG-EELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|115502442|sp|Q9XT96.2|PSN2_BOVIN (RecName: Full=Presenilin-2; Short=PS-2; Contains: RecName: Full=Presenilin-2 NTF subunit; Contains: RecName: Full=Presenilin-2 CTF subunit)

HSP 1 Score: 399.823 bits (1026), Expect = 2.369e-136
Identity = 224/376 (59.57%), Postives = 277/376 (73.67%), Query Frame = 0

Query:   23 EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA--DSSSD-----PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            EEE  + +GAK+VIMLF PVTLCM  VV TI SV  YTE++G  L+YTPF E + + G    N+  N  I+++VI  MT+ L++ YKY+C   IHGWL +SS MLLFLF+YI+LGEVLKTYN+ MDY TL   +WNFG VGM+ IHWK PL+LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ ++++V GMA  D SS      P  P    D+     E    ++  PPL         EEEE+RG+KLGLGDFIFYS+LVGKA++   GDWNTTLACFVAILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  ++ PFMD ++S Q+YI
Sbjct:   77 EEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFSEDTPSVGQRLLNSVLNTLIMISVIVTMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV-GMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPDVFEPPLPGYPG-EELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 449          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|37154738|sp|Q61144.3|PSN2_MOUSE (RecName: Full=Presenilin-2; Short=PS-2; Contains: RecName: Full=Presenilin-2 NTF subunit; Contains: RecName: Full=Presenilin-2 CTF subunit)

HSP 1 Score: 398.667 bits (1023), Expect = 6.663e-136
Identity = 230/403 (57.07%), Postives = 282/403 (69.98%), Query Frame = 0

Query:    2 SSEGEEVRIRDPRRREVQELE------EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA--DSSSD-----PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            + E EE    DP R             EEE  + +GAK VIMLF PVTLCM  VV TI SV  YTE++G  L+YTPF E + + G    N+  N  I+++VI VMT+ L++ YKY+C   IHGWL +SS MLLFLF+YI+LGEVLKTYN+ MDY TL   +WNFG VGM+ IHWK PL+LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ ++++V GMA  D SS      P  P    D+     E    E    PL         EEEE+RG+KLGLGDFIFYS+LVGKA++   GDWNTTLACF+AILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  ++ PFMD ++S Q+YI
Sbjct:   49 TQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKRVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV-GMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPG-EELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|6174932|sp|O88777.2|PSN2_RAT (RecName: Full=Presenilin-2; Short=PS-2; Contains: RecName: Full=Presenilin-2 NTF subunit; Contains: RecName: Full=Presenilin-2 CTF subunit)

HSP 1 Score: 389.808 bits (1000), Expect = 2.053e-132
Identity = 227/403 (56.33%), Postives = 282/403 (69.98%), Query Frame = 0

Query:    2 SSEGEEVRIRDPRRREVQELE------EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA--DSSSD-----PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            S E E+    DP       +       EEE  + +GAK+VIMLF PVTLCM  VV TI SV  YTE++G  L+YTPF E + + G    N+  N  I+++VI VMT+ L++ YKY+C   IHGWL +SS MLLFLF+YI+LGEV KTYN+ MDY TL   +WNFG VGM+ IHWK PL+LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ ++++V GMA  D SS      P  P    D+     E    E    P Q        EEEE+RG+KLGLGDFIFYS+LVGKA++   GDW+TTLACF+AILIGLCLTL+ LA+F+KALPALPISITFGLIFYF T  ++ PFMD ++S Q+YI
Sbjct:   49 SQENEDDCEEDPDHYACSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVFKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV-GMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAP-QPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|6093850|sp|P79801.1|PSN2_MICMU (RecName: Full=Presenilin-2; Short=PS-2; Contains: RecName: Full=Presenilin-2 NTF subunit; Contains: RecName: Full=Presenilin-2 CTF subunit)

HSP 1 Score: 387.497 bits (994), Expect = 1.588e-131
Identity = 224/398 (56.28%), Postives = 278/398 (69.85%), Query Frame = 0

Query:    4 EGEEVRIRDPRRREVQELE------EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA--DSSSD-----PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSY--GDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQ 386
            + EE    DP R     +       EEE  + +GAK+VIML  PVTLCM  VV TI SV  YTE++G  L+YTPF E + +      N+  N  I+++VI VMT+ L++ YKY+C   IHGWL +SS MLLFLF+YI+LGEVLKTYN+ MDY TL   +WNFG VGM+ IHWK PL+LQQ+YLI ISAL+AL FIKYLP ++ W +L  IS++ L AVL P GPLR+LVETAQERNEPIFP+LIYS+ ++++V GMA  D SS      P  P    D+     E    E+   PL         EEEE+RG+KLGLGDFIFYS+LVGKA++   GDWNTTLACFVAILIGLCLTL+ LA+F+KALPALPISITFGL+FYF T  ++ PFMD ++  Q
Sbjct:   51 DSEEDGEEDPDRYVSSGVPGRPPGPEEELTLKYGAKHVIMLSVPVTLCMIVVVATIKSVRFYTEKNGQ-LIYTPFTEDTPSVSQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLVLTVWNFGAVGMVCIHWKGPLMLQQAYLIAISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV-GMAKLDPSSQGALQLPYDPEMEEDSYDSLGEPSYPEVFEAPLPGYPG-EELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLVFYFSTDNLVRPFMDTLAYHQ 445          

BLAST of EMLSAG00000000448 vs. SwissProt
Match: gi|21264494|sp|P52166.2|PSN_CAEEL (RecName: Full=Presenilin sel-12; AltName: Full=Suppressor/enhancer of lin-12 protein 12)

HSP 1 Score: 384.415 bits (986), Expect = 2.117e-130
Identity = 208/413 (50.36%), Postives = 273/413 (66.10%), Query Frame = 0

Query:   15 RREVQELEE--EEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVI--------------------------GMADSSSD-PKRPNRRRDNQRMAAESQX-------------QELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSR 385
             R  QE E   EE  + +GA +VI LF PV+LCMA VV T+ ++T Y++ +G +L+YTPF   +D+       +  NA ++L V+ +MTV+LI+ YKYK   LIHGWL +SSF+LLFLF+ I++ EVLK++++    + + F + N+GV+GMM IHWK PL LQQ YLI +SAL+AL FIKYLP +T W VL  IS+W L AVL P GPLR LVETAQERNEPIFP+LIYS+G++Y  +                          G A  SS+ PKRP  +R  Q++  ES               +EL+      Q       EEE+RG+KLGLGDFIFYS+L+GKASSY DWNTT+AC+VAILIGLC TL+ LA+F++ALPALPISI  GLIFYF T+ IITPF+ ++S +
Sbjct:   28 NRNSQEDENVVEEAELKYGASHVIHLFVPVSLCMALVVFTMNTITFYSQNNGRHLLYTPFVRETDSIVEKGLMSLGNALVMLCVVVLMTVLLIVFYKYKFYKLIHGWLIVSSFLLLFLFTTIYVQEVLKSFDVSPSALLVLFGLGNYGVLGMMCIHWKGPLRLQQFYLITMSALMALVFIKYLPEWTVWFVLFVISVWDLVAVLTPKGPLRYLVETAQERNEPIFPALIYSSGVIYPYVLVTAVENTTDPREPTSSDSNTSTAFPGEASCSSETPKRPKVKRIPQKVQIESNTTASTTQNSGVRVERELAAERPTVQDANFHRHEEEERGVKLGLGDFIFYSVLLGKASSYFDWNTTIACYVAILIGLCFTLVLLAVFKRALPALPISIFSGLIFYFCTRWIITPFVTQVSQK 440          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: gb|EFA07178.2| (Presenilin homolog-like Protein [Tribolium castaneum])

HSP 1 Score: 439.884 bits (1130), Expect = 3.414e-152
Identity = 237/395 (60.00%), Postives = 291/395 (73.67%), Query Frame = 0

Query:   13 PRRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD--PKRPNRRR----------------DNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            P   EV EL +EE  + +GAK+VI LF PV+LCM  VV TI +V  Y+ +D  YLVYTPFHE S +  T  WNA AN+ IL+AVI VMTV+LI+ YKY+C   IHGWL LSS MLL +FSY++L E+L+ YN+PMDY T+  +MWNFGV+GM+ IHW+ PL+LQQ+YLIF++AL+AL FIKYLP +TTWAVLA IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+  MY+   MA  S+D  P R    R                DN       +  E+   P +   +  + +EEE+RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF TKEI++PF D +++ Q++I
Sbjct:   71 PVDYEVAELRDEEEELKYGAKHVIKLFAPVSLCMVVVVATISAVNFYSVKD-MYLVYTPFHEESSDTSTKVWNAAANSLILMAVIVVMTVLLIVLYKYRCYKTIHGWLILSSLMLLTVFSYLYLEEILRAYNIPMDYPTIVLLMWNFGVMGMVCIHWQGPLVLQQAYLIFVAALMALVFIKYLPEWTTWAVLAVISVWDLVAVLMPKGPLRILVETAQERNEQIFPALIYSSTYMYAYTSMATPSNDENPPRGAAARSSADSTEEHGFTQDWVDNHSSRVAQRRLEVHDVP-RGAPRTQIHQEEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATKEIVSPFADSLANEQVFI 463          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: EEB13397.1 (conserved hypothetical protein [Pediculus humanus corporis])

HSP 1 Score: 427.172 bits (1097), Expect = 5.414e-147
Identity = 240/398 (60.30%), Postives = 284/398 (71.36%), Query Frame = 0

Query:   23 EEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGM-ADSSSDP----KRPNRRRD------------------NQRMAAESQXQELSPPPLQQQQQP--------PVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            +EE  + +GAK+VI LF PV+LCM  VV TI S+  YT  D  Y VYTPFHE   NPGT AWNA AN+ IL+AVI VMT++LII YK +C   IHGWL  SS MLLFLFSY++L EVL+ YN+PMDY TL  IMWNFGVVGM+ IHWK PLLLQQ+YLIFI+AL+AL FIKYLP +T W VLA IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+  MY+ + M ++ + +P    K  N  R+                   +R   E Q  E+   P Q +            V  EEE+RG+KLGLGDFIFYS+LVGKASSYGDWNTT+ACFVAILIGLCLTL+ LA+FRKALPALPISITFGLIFYF TK+I+ PF D ++  QI+I
Sbjct:   81 QEELELKYGAKHVIKLFAPVSLCMLVVVATISSIKFYTTSDM-YFVYTPFHETDSNPGTKAWNAVANSLILIAVIVVMTIVLIILYKKRCYKTIHGWLIASSLMLLFLFSYLYLEEVLRAYNIPMDYFTLTIIMWNFGVVGMICIHWKGPLLLQQAYLIFIAALMALVFIKYLPEWTAWVVLAVISIWDLIAVLTPRGPLRILVETAQERNEQIFPALIYSSTFMYNYVNMTSEETKNPTSSLKESNSTRNFEEDPESGFVRGWMNPQRAKRRNEEIQQSEVRFHPQQSEGHSNPGPVGTNAVTVEEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTVACFVAILIGLCLTLLLLAVFRKALPALPISITFGLIFYFTTKKIVKPFADNLAGEQIFI 477          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: EFX90351.1 (putative protease presenilin [Daphnia pulex])

HSP 1 Score: 422.165 bits (1084), Expect = 2.098e-145
Identity = 233/388 (60.05%), Postives = 288/388 (74.23%), Query Frame = 0

Query:   29 NHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMAD-------------SSSDPKRPN--------RRRDNQRMAAES---QXQELSPPPLQQQQQP---PVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
             +GA +VI LF PV+LCM  VV TI SVT YT++ G YLVYTPFHE S + GT  WNA ANA ILL VI VMTV LI+ YKY+C  +IHGWL +SS MLLF+F+Y++LGEVL+TYN+P+DYI+L FIMWNFGVVGM++IHWKAPL LQQ+YLIF++AL+AL FIKYLP +TTW VL  IS+W L AVL+P GPLRILVETAQ RNEP+FP+LIYS+ + Y  +   D             +++ P+ P          +   QR  A     Q      P    Q QP    ++++EE+RGIKLGLGDFIFYS+LVGKASSYGDWNTT+ACFVAILIGLCLTL+ LAIFRKALPALPISITFGL+FYF T +++ PF D ++++Q++I
Sbjct:   62 KYGAAHVIKLFVPVSLCMMVVVATISSVTYYTQK-GIYLVYTPFHEDSPDTGTKVWNAVANAAILLGVIVVMTVFLIMLYKYRCYKIIHGWLIMSSLMLLFIFAYLYLGEVLRTYNIPLDYISLLFIMWNFGVVGMIAIHWKAPLHLQQAYLIFVAALMALVFIKYLPEWTTWVVLGVISIWDLVAVLSPRGPLRILVETAQSRNEPLFPALIYSSTVAYMAVMATDQSSTSNSTSNNETAANGPRSPTDGGFTPAWNQEAEQRTEARRHRVQAAAAEAPRAAPQPQPVTEEIDDDEEERGIKLGLGDFIFYSVLVGKASSYGDWNTTIACFVAILIGLCLTLLLLAIFRKALPALPISITFGLVFYFATSKLVAPFADSLTAQQVFI 448          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: gb|EEC13172.1| (presenilin, putative, partial [Ixodes scapularis])

HSP 1 Score: 419.468 bits (1077), Expect = 1.472e-144
Identity = 230/424 (54.25%), Postives = 292/424 (68.87%), Query Frame = 0

Query:    2 SSEGEEVRIRDPRRREVQELEEE-----EFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMAD------------SSSDPKRPNRRRDNQRM---------------AAESQXQELSPPPLQQQQQPPVEE----EEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            S EG EV ++       +   E      E  + +GAK+VI LF PV+LCM  VV TI S++ Y   +  YLVYTPF + + + GT  W +FANA IL+ VI VMT++LI+ YK++C  +IH WL +SS +L+FLF+YI+LGEVL+ YN+PMDY+T+A +MWNFGVVGM+SIHWK PLLLQQ+YLI +SAL+AL FIKYLP++T W VL  IS+W L AVL P GPLRILVETAQERNEPIFP+LIYS+ ++++V+ MAD            S SD      RR                     + +    L+     Q   P V++    EEE+RG+KLGLGDFIFYS+LVGKASSYGDWNTT+ACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF T  ++ PF D ++  Q++I
Sbjct:    9 SREGTEVDLQPASGGGGRAWGESGTEEEEEELKYGAKHVIRLFVPVSLCMLVVVATISSISFYRHTN-TYLVYTPFTDQTVDTGTKVWQSFANAFILMGVIVVMTILLILLYKFRCYKVIHAWLIVSSLLLVFLFAYIYLGEVLRAYNVPMDYLTVALVMWNFGVVGMISIHWKGPLLLQQAYLILVSALMALVFIKYLPDWTAWVVLGVISVWDLIAVLCPKGPLRILVETAQERNEPIFPALIYSSAMVWNVVTMADRDPFYSSQNQHASQSDASSGTSRRPCSTFPRMRGSGRSRRRSQRGSMANSGTLAALGSSQGSAPEVDDLPRQEEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATSSLVQPFADSLAGEQVFI 431          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: gb|KFM74765.1| (hypothetical protein X975_10848, partial [Stegodyphus mimosarum])

HSP 1 Score: 418.698 bits (1075), Expect = 3.348e-143
Identity = 235/417 (56.35%), Postives = 289/417 (69.30%), Query Frame = 0

Query:   11 RDPRRREVQEL----EEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDN--------QRMAAESQX---QELSPPPLQQQ-----------------------QQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            R PR      L    E+EE  + +GAK+VI LF PV+LCM  VV T  S+T YT+ +  YLVYTPF + + +  T  W +FANA IL+ VI  MT++LI+ YK++   +IHGWL +SS MLLFLF+YI+LGEVL+ YN+PMDYIT++ IMWNFGVVGM+ IHW+ PLLLQQ+YLI +SAL+AL FIKYLPN+T W VL  IS+W L AVL P GPLRILVETAQERNEPIFP+LIYS+ + + V  M+D  SD    NRR  +        +  AA ++     E  P  L+                          Q  V  EE++RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF T  ++ PF D ++S Q+YI
Sbjct:   99 RSPRVHSRPNLQSWDEDEEEELKYGAKHVIKLFIPVSLCMLVVVATTSSITFYTQTN-TYLVYTPFTDQTVDTPTKVWQSFANAFILMGVIVCMTILLILLYKFRWYKVIHGWLIVSSLMLLFLFAYIYLGEVLRAYNIPMDYITVSIIMWNFGVVGMICIHWRGPLLLQQAYLILVSALMALVFIKYLPNWTAWVVLGVISVWDLIAVLCPKGPLRILVETAQERNEPIFPALIYSSAMAWYVT-MSD--SDHTVRNRRHSDGDGNPNEPENTAASNEADIPNETGPHNLEGSNRSSERSRRATGWPSGSGSHPLPSQTEVHTEEDERGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFTTSSLVQPFADSLASEQVYI 511          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: AGB94803.1 (presenilin, isoform D [Drosophila melanogaster])

HSP 1 Score: 398.667 bits (1023), Expect = 3.548e-135
Identity = 226/443 (51.02%), Postives = 291/443 (65.69%), Query Frame = 0

Query:   18 VQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVI-----------------------------------------GMADSSSDPKRPNRRRDNQRMAAESQX----QELSPPPLQQQQQPPVE--------------------------EEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              E+EEE+ +  +GA++VI LF PV+LCM  VV TI S++ Y   D  YL+YTPFHE S  P    W+A AN+ IL++V+ VMT +LI+ YK +C  +IHGWL LSSFMLLF+F+Y++L E+L+ YN+PMDY T   IMWNFGVVGMMSIHW+ PL LQQ YLIF++AL+AL FIKYLP +T WAVLA IS+W L AVL+P GPLRILVETAQERNE IFP+LIYS+ ++Y+++                                         G    +S P R N+R D   +A E++     QE S    ++  +  +E                          + +E+RGIKLGLGDFIFYS+LVGKASSYGDW TT+ACFVAILIGLCLTL+ LAI+RKALPALPISITFGLIF F T  ++ PFM+++S++Q++I
Sbjct:   88 TNEMEEEQGL-KYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTD-VYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHP-RQNQRDDGSVLATEAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI 527          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: AAN12132.1 (presenilin, isoform B [Drosophila melanogaster])

HSP 1 Score: 398.667 bits (1023), Expect = 3.548e-135
Identity = 226/443 (51.02%), Postives = 291/443 (65.69%), Query Frame = 0

Query:   18 VQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVI-----------------------------------------GMADSSSDPKRPNRRRDNQRMAAESQX----QELSPPPLQQQQQPPVE--------------------------EEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
              E+EEE+ +  +GA++VI LF PV+LCM  VV TI S++ Y   D  YL+YTPFHE S  P    W+A AN+ IL++V+ VMT +LI+ YK +C  +IHGWL LSSFMLLF+F+Y++L E+L+ YN+PMDY T   IMWNFGVVGMMSIHW+ PL LQQ YLIF++AL+AL FIKYLP +T WAVLA IS+W L AVL+P GPLRILVETAQERNE IFP+LIYS+ ++Y+++                                         G    +S P R N+R D   +A E++     QE S    ++  +  +E                          + +E+RGIKLGLGDFIFYS+LVGKASSYGDW TT+ACFVAILIGLCLTL+ LAI+RKALPALPISITFGLIF F T  ++ PFM+++S++Q++I
Sbjct:   88 TNEMEEEQGL-KYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTD-VYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHP-RQNQRDDGSVLATEAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI 527          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: XP_396620.4 (PREDICTED: presenilin-1 [Apis mellifera])

HSP 1 Score: 387.497 bits (994), Expect = 3.622e-131
Identity = 232/427 (54.33%), Postives = 280/427 (65.57%), Query Frame = 0

Query:   14 RRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMY---------------------------------------SVIGMA----------DSSSD--PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            R R  ++ EEEE  + +GA +VI LF PV+LCM  VV TI S+  YT + G YLVYTPFHE S +  T AW A AN+ IL++VI  MTVILI+ YKYK   +IHGWL +SS +LL +FS ++  +VLK YN+PMD  TL  ++WNFGVVGM+ IHW+ PL LQQ+YLIFISAL+AL FIKYLP +T W VL  IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+ IMY                                       S  G A          D+  D   +R    R+N     E   Q+       Q QQ P+ EEE  RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPIS+TFGL FYF T+ I+ PF D+++S Q++I
Sbjct:   79 RSRNYRDEEEEE--LKYGAAHVIKLFVPVSLCMLVVVATISSINFYTTK-GMYLVYTPFHEDSADTSTKAWQAVANSLILMSVIVFMTVILIVLYKYKFYKVIHGWLIISSLLLLSMFSMLYCEQVLKAYNIPMDLYTLGLVLWNFGVVGMICIHWQGPLQLQQAYLIFISALMALVFIKYLPEWTAWVVLGVISIWDLIAVLTPKGPLRILVETAQERNESIFPALIYSSTIMYTATMTYAGYVQTATMTTNDTTASDNTTYTMNNQANNQNNSTSGDAEEGGFTPEWIDTHGDRGARRAQEVRENTLSLTERSRQDNRVARESQGQQVPITEEE--RGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISVTFGLTFYFATRVIVAPFADKLASEQVFI 500          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: XP_016767700.1 (PREDICTED: presenilin-1 [Apis mellifera])

HSP 1 Score: 387.497 bits (994), Expect = 3.622e-131
Identity = 232/427 (54.33%), Postives = 280/427 (65.57%), Query Frame = 0

Query:   14 RRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMY---------------------------------------SVIGMA----------DSSSD--PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            R R  ++ EEEE  + +GA +VI LF PV+LCM  VV TI S+  YT + G YLVYTPFHE S +  T AW A AN+ IL++VI  MTVILI+ YKYK   +IHGWL +SS +LL +FS ++  +VLK YN+PMD  TL  ++WNFGVVGM+ IHW+ PL LQQ+YLIFISAL+AL FIKYLP +T W VL  IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+ IMY                                       S  G A          D+  D   +R    R+N     E   Q+       Q QQ P+ EEE  RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPIS+TFGL FYF T+ I+ PF D+++S Q++I
Sbjct:   79 RSRNYRDEEEEE--LKYGAAHVIKLFVPVSLCMLVVVATISSINFYTTK-GMYLVYTPFHEDSADTSTKAWQAVANSLILMSVIVFMTVILIVLYKYKFYKVIHGWLIISSLLLLSMFSMLYCEQVLKAYNIPMDLYTLGLVLWNFGVVGMICIHWQGPLQLQQAYLIFISALMALVFIKYLPEWTAWVVLGVISIWDLIAVLTPKGPLRILVETAQERNESIFPALIYSSTIMYTATMTYAGYVQTATMTTNDTTASDNTTYTMNNQANNQNNSTSGDAEEGGFTPEWIDTHGDRGARRAQEVRENTLSLTERSRQDNRVARESQGQQVPITEEE--RGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISVTFGLTFYFATRVIVAPFADKLASEQVFI 500          

BLAST of EMLSAG00000000448 vs. Select Arthropod Genomes
Match: XP_016767699.1 (PREDICTED: presenilin-1 [Apis mellifera])

HSP 1 Score: 387.497 bits (994), Expect = 3.622e-131
Identity = 232/427 (54.33%), Postives = 280/427 (65.57%), Query Frame = 0

Query:   14 RRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMY---------------------------------------SVIGMA----------DSSSD--PKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            R R  ++ EEEE  + +GA +VI LF PV+LCM  VV TI S+  YT + G YLVYTPFHE S +  T AW A AN+ IL++VI  MTVILI+ YKYK   +IHGWL +SS +LL +FS ++  +VLK YN+PMD  TL  ++WNFGVVGM+ IHW+ PL LQQ+YLIFISAL+AL FIKYLP +T W VL  IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+ IMY                                       S  G A          D+  D   +R    R+N     E   Q+       Q QQ P+ EEE  RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPIS+TFGL FYF T+ I+ PF D+++S Q++I
Sbjct:   79 RSRNYRDEEEEE--LKYGAAHVIKLFVPVSLCMLVVVATISSINFYTTK-GMYLVYTPFHEDSADTSTKAWQAVANSLILMSVIVFMTVILIVLYKYKFYKVIHGWLIISSLLLLSMFSMLYCEQVLKAYNIPMDLYTLGLVLWNFGVVGMICIHWQGPLQLQQAYLIFISALMALVFIKYLPEWTAWVVLGVISIWDLIAVLTPKGPLRILVETAQERNESIFPALIYSSTIMYTATMTYAGYVQTATMTTNDTTASDNTTYTMNNQANNQNNSTSGDAEEGGFTPEWIDTHGDRGARRAQEVRENTLSLTERSRQDNRVARESQGQQVPITEEE--RGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISVTFGLTFYFATRVIVAPFADKLASEQVFI 500          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|676433820|ref|XP_009047025.1| (hypothetical protein LOTGIDRAFT_138705 [Lottia gigantea] >gi|556113665|gb|ESP02317.1| hypothetical protein LOTGIDRAFT_138705 [Lottia gigantea])

HSP 1 Score: 458.759 bits (1179), Expect = 1.121e-157
Identity = 223/370 (60.27%), Postives = 277/370 (74.86%), Query Frame = 0

Query:   30 HGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQRMAAESQXQELSPP--------PLQQQ--QQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            +GA +VIMLF PVTLCMA VV TI SVT YTE+   YL+YTPFH+ +D+ GT  W +FANA ILL VI V+T+ L++ YK++C  +IHGWL +SS MLLFLFSYI+LGEVL+ YN+PMDY+T+  +MWNFGVVGM+ IHWK PLLLQQ+YLI ISAL+AL FIKYLP++TTW VL  + +W L AVL P GPLR+LVETAQERNEPIFP+LIYS            +S++  R   R   Q +   +  Q ++ P        P Q+      P  ++EE+RG+KLGLGDFIFY +LVGKASSYGDWNTTLACFVAILIGLC TL+ LAIF+KALPALPISITFGL+F F T  ++ PFMD +++ Q+Y+
Sbjct:   49 YGANSVIMLFVPVTLCMAVVVATISSVTFYTEKTDGYLIYTPFHDKTDDTGTKLWQSFANAFILLGVICVLTIFLLLLYKFRCYKVIHGWLIVSSLMLLFLFSYIYLGEVLRAYNVPMDYVTVIILMWNFGVVGMVCIHWKGPLLLQQAYLIMISALMALIFIKYLPDWTTWVVLGVMVVWDLVAVLCPKGPLRVLVETAQERNEPIFPALIYSCKCNTRYSSPMTASTESTRA--RNAVQALNTTNNYQTIADPDRPPGTATPNQRSSTNSQPQTQDEEERGVKLGLGDFIFYGVLVGKASSYGDWNTTLACFVAILIGLCFTLLLLAIFKKALPALPISITFGLVFNFATSSLVQPFMDSLAAEQVYL 416          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|961128754|ref|XP_014785183.1| (PREDICTED: presenilin-1-like isoform X4 [Octopus bimaculoides])

HSP 1 Score: 460.685 bits (1184), Expect = 3.382e-157
Identity = 228/379 (60.16%), Postives = 281/379 (74.14%), Query Frame = 0

Query:   32 AKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNRRRDNQ-----------RMAAESQXQELSPPPLQQQQQPPVEEEEED----------RGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            AK+VIMLF PVTLCM  VV TI SVT YT+  G YL+YTPFHE +D+ GT  W +FANA ILL VIAVMTV+L++ YKY+C  +IHGWL +SS +LLF+FSY++LGEVLK YN PMDYIT+A +MWNFGV+GM+ IHWK PLLLQQ+YL+ ISAL+AL FIKYLP++TTW+VL  +  W L AVL P GPLR+LVETAQ RNE IFP+LIYS+ +++ ++ MAD S  PKR +                 R A ++  +  + P  +   +PP +  +            RG+KLGLGDFIFY +LVGKASSYGDWNTTLACFVAILIGLC TL+ LAIFRKALPALPISITFGLIF F T+ ++ PFMD ++S Q+YI
Sbjct:  119 AKHVIMLFVPVTLCMIVVVATISSVTYYTQP-GGYLIYTPFHEETDDSGTKVWQSFANAFILLGVIAVMTVVLLLLYKYRCYKVIHGWLIVSSLLLLFMFSYMYLGEVLKAYNAPMDYITVAILMWNFGVIGMICIHWKGPLLLQQAYLLMISALMALIFIKYLPDWTTWSVLGIMVFWDLVAVLCPKGPLRVLVETAQHRNEDIFPALIYSSTMVWQIVTMADES--PKRDSGANSTSTLATDVHSSPARRAIDALGEMENDPNSEANNRPPADRNQRSQGSGEEEEEERGVKLGLGDFIFYGVLVGKASSYGDWNTTLACFVAILIGLCFTLLLLAIFRKALPALPISITFGLIFNFATRGLVRPFMDNLASEQMYI 494          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|961128751|ref|XP_014785182.1| (PREDICTED: presenilin-1-like isoform X3 [Octopus bimaculoides] >gi|918293130|gb|KOF70540.1| hypothetical protein OCBIM_22002682mg [Octopus bimaculoides])

HSP 1 Score: 450.669 bits (1158), Expect = 4.011e-153
Identity = 230/411 (55.96%), Postives = 283/411 (68.86%), Query Frame = 0

Query:   32 AKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNR------------------------------RRD-------------NQRMAAESQXQELSPPPLQQQQQPPVEEEEED----------RGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            AK+VIMLF PVTLCM  VV TI SVT YT+  G YL+YTPFHE +D+ GT  W +FANA ILL VIAVMTV+L++ YKY+C  +IHGWL +SS +LLF+FSY++LGEVLK YN PMDYIT+A +MWNFGV+GM+ IHWK PLLLQQ+YL+ ISAL+AL FIKYLP++TTW+VL  +  W L AVL P GPLR+LVETAQ RNE IFP+LIYS+ +++ ++ MAD S  PKR +                               R D               R A ++  +  + P  +   +PP +  +            RG+KLGLGDFIFY +LVGKASSYGDWNTTLACFVAILIGLC TL+ LAIFRKALPALPISITFGLIF F T+ ++ PFMD ++S Q+YI
Sbjct:  100 AKHVIMLFVPVTLCMIVVVATISSVTYYTQP-GGYLIYTPFHEETDDSGTKVWQSFANAFILLGVIAVMTVVLLLLYKYRCYKVIHGWLIVSSLLLLFMFSYMYLGEVLKAYNAPMDYITVAILMWNFGVIGMICIHWKGPLLLQQAYLLMISALMALIFIKYLPDWTTWSVLGIMVFWDLVAVLCPKGPLRVLVETAQHRNEDIFPALIYSSTMVWQIVTMADES--PKRDSGANSTSTLATDVHSSPATNATSNPEAGTNIYRNDVDAHNLTNSIDSQTARRAIDALGEMENDPNSEANNRPPADRNQRSQGSGEEEEEERGVKLGLGDFIFYGVLVGKASSYGDWNTTLACFVAILIGLCFTLLLLAIFRKALPALPISITFGLIFNFATRGLVRPFMDNLASEQMYI 507          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|961128748|ref|XP_014785181.1| (PREDICTED: presenilin-1-like isoform X2 [Octopus bimaculoides] >gi|918293129|gb|KOF70539.1| hypothetical protein OCBIM_22002682mg [Octopus bimaculoides])

HSP 1 Score: 451.055 bits (1159), Expect = 5.057e-153
Identity = 230/411 (55.96%), Postives = 283/411 (68.86%), Query Frame = 0

Query:   32 AKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNR------------------------------RRD-------------NQRMAAESQXQELSPPPLQQQQQPPVEEEEED----------RGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            AK+VIMLF PVTLCM  VV TI SVT YT+  G YL+YTPFHE +D+ GT  W +FANA ILL VIAVMTV+L++ YKY+C  +IHGWL +SS +LLF+FSY++LGEVLK YN PMDYIT+A +MWNFGV+GM+ IHWK PLLLQQ+YL+ ISAL+AL FIKYLP++TTW+VL  +  W L AVL P GPLR+LVETAQ RNE IFP+LIYS+ +++ ++ MAD S  PKR +                               R D               R A ++  +  + P  +   +PP +  +            RG+KLGLGDFIFY +LVGKASSYGDWNTTLACFVAILIGLC TL+ LAIFRKALPALPISITFGLIF F T+ ++ PFMD ++S Q+YI
Sbjct:  112 AKHVIMLFVPVTLCMIVVVATISSVTYYTQP-GGYLIYTPFHEETDDSGTKVWQSFANAFILLGVIAVMTVVLLLLYKYRCYKVIHGWLIVSSLLLLFMFSYMYLGEVLKAYNAPMDYITVAILMWNFGVIGMICIHWKGPLLLQQAYLLMISALMALIFIKYLPDWTTWSVLGIMVFWDLVAVLCPKGPLRVLVETAQHRNEDIFPALIYSSTMVWQIVTMADES--PKRDSGANSTSTLATDVHSSPATNATSNPEAGTNIYRNDVDAHNLTNSIDSQTARRAIDALGEMENDPNSEANNRPPADRNQRSQGSGEEEEEERGVKLGLGDFIFYGVLVGKASSYGDWNTTLACFVAILIGLCFTLLLLAIFRKALPALPISITFGLIFNFATRGLVRPFMDNLASEQMYI 519          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|961128745|ref|XP_014785180.1| (PREDICTED: presenilin-1-like isoform X1 [Octopus bimaculoides] >gi|918293128|gb|KOF70538.1| hypothetical protein OCBIM_22002682mg [Octopus bimaculoides])

HSP 1 Score: 450.284 bits (1157), Expect = 9.834e-153
Identity = 230/411 (55.96%), Postives = 283/411 (68.86%), Query Frame = 0

Query:   32 AKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPKRPNR------------------------------RRD-------------NQRMAAESQXQELSPPPLQQQQQPPVEEEEED----------RGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            AK+VIMLF PVTLCM  VV TI SVT YT+  G YL+YTPFHE +D+ GT  W +FANA ILL VIAVMTV+L++ YKY+C  +IHGWL +SS +LLF+FSY++LGEVLK YN PMDYIT+A +MWNFGV+GM+ IHWK PLLLQQ+YL+ ISAL+AL FIKYLP++TTW+VL  +  W L AVL P GPLR+LVETAQ RNE IFP+LIYS+ +++ ++ MAD S  PKR +                               R D               R A ++  +  + P  +   +PP +  +            RG+KLGLGDFIFY +LVGKASSYGDWNTTLACFVAILIGLC TL+ LAIFRKALPALPISITFGLIF F T+ ++ PFMD ++S Q+YI
Sbjct:  119 AKHVIMLFVPVTLCMIVVVATISSVTYYTQP-GGYLIYTPFHEETDDSGTKVWQSFANAFILLGVIAVMTVVLLLLYKYRCYKVIHGWLIVSSLLLLFMFSYMYLGEVLKAYNAPMDYITVAILMWNFGVIGMICIHWKGPLLLQQAYLLMISALMALIFIKYLPDWTTWSVLGIMVFWDLVAVLCPKGPLRVLVETAQHRNEDIFPALIYSSTMVWQIVTMADES--PKRDSGANSTSTLATDVHSSPATNATSNPEAGTNIYRNDVDAHNLTNSIDSQTARRAIDALGEMENDPNSEANNRPPADRNQRSQGSGEEEEEERGVKLGLGDFIFYGVLVGKASSYGDWNTTLACFVAILIGLCFTLLLLAIFRKALPALPISITFGLIFNFATRGLVRPFMDNLASEQMYI 526          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|762116485|ref|XP_011441079.1| (PREDICTED: presenilin-1-like [Crassostrea gigas] >gi|405958341|gb|EKC24477.1| Presenilin-2 [Crassostrea gigas])

HSP 1 Score: 444.121 bits (1141), Expect = 1.009e-150
Identity = 233/406 (57.39%), Postives = 284/406 (69.95%), Query Frame = 0

Query:   30 HGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHE---LSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD--------------------------------PKRPNRRRDNQ-----------RMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            +GAK+VIMLF PV+LCMA VV TI SVT YTE+ G YLVYTPFH+      + GT  W + ANA ILL VI VMT++L++ YK++C  +IHGWL  SS MLLFLFSYI+LG VL+ YN+ MDYIT+A +MWNFGVVGM+ IHWK PL LQQ+YLI ISAL+AL FIKYLP++TTW VL  + +W L AVL P GPLRILVETAQERNEPIFP+LIYS+ +++SV+GMAD  SD                                 +RP R+               R+  +++  + +  P    ++   EEEEE+RG+KLGLGDFIFY +LVGKASS GDWNTTLACFVAILIGLC TL+ LAIFRKALPALPISITFGLIF F T  ++ PF D +S+ Q+YI
Sbjct:   85 YGAKHVIMLFVPVSLCMAVVVATISSVTFYTEK-GGYLVYTPFHDGDKADADTGTKVWQSVANALILLGVICVMTIVLLLLYKFRCYKVIHGWLIASSLMLLFLFSYIYLGVVLQAYNVAMDYITVALLMWNFGVVGMICIHWKGPLFLQQAYLIVISALMALVFIKYLPDWTTWVVLGVMVIWDLVAVLCPKGPLRILVETAQERNEPIFPALIYSSTMIWSVVGMADDGSDKKKKKKKKSKKKPEAATAEPDQVEAELDGGFLEERPTRQLSQSTEETARAVRAARVLGDTENGQRTNSPRNPTREEEEEEEEEERGVKLGLGDFIFYGVLVGKASSNGDWNTTLACFVAILIGLCFTLLLLAIFRKALPALPISITFGLIFNFTTSLLVQPFADRLSASQVYI 489          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|189239692|ref|XP_967139.2| (PREDICTED: presenilin homolog [Tribolium castaneum] >gi|1004398157|gb|EFA07178.2| Presenilin homolog-like Protein [Tribolium castaneum])

HSP 1 Score: 439.884 bits (1130), Expect = 1.670e-149
Identity = 237/395 (60.00%), Postives = 291/395 (73.67%), Query Frame = 0

Query:   13 PRRREVQELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSD--PKRPNRRR----------------DNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            P   EV EL +EE  + +GAK+VI LF PV+LCM  VV TI +V  Y+ +D  YLVYTPFHE S +  T  WNA AN+ IL+AVI VMTV+LI+ YKY+C   IHGWL LSS MLL +FSY++L E+L+ YN+PMDY T+  +MWNFGV+GM+ IHW+ PL+LQQ+YLIF++AL+AL FIKYLP +TTWAVLA IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+  MY+   MA  S+D  P R    R                DN       +  E+   P +   +  + +EEE+RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF TKEI++PF D +++ Q++I
Sbjct:   71 PVDYEVAELRDEEEELKYGAKHVIKLFAPVSLCMVVVVATISAVNFYSVKD-MYLVYTPFHEESSDTSTKVWNAAANSLILMAVIVVMTVLLIVLYKYRCYKTIHGWLILSSLMLLTVFSYLYLEEILRAYNIPMDYPTIVLLMWNFGVMGMVCIHWQGPLVLQQAYLIFVAALMALVFIKYLPEWTTWAVLAVISVWDLVAVLMPKGPLRILVETAQERNEQIFPALIYSSTYMYAYTSMATPSNDENPPRGAAARSSADSTEEHGFTQDWVDNHSSRVAQRRLEVHDVP-RGAPRTQIHQEEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATKEIVSPFADSLANEQVFI 463          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|1133416830|ref|XP_019881318.1| (PREDICTED: LOW QUALITY PROTEIN: presenilin homolog [Aethina tumida])

HSP 1 Score: 434.876 bits (1117), Expect = 9.204e-148
Identity = 233/382 (60.99%), Postives = 281/382 (73.56%), Query Frame = 0

Query:   19 QELEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSS-----------DPKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            QE EEEE  + +GAK+VI LF PV+LCM  VV TI SV  Y+ +D  Y +YTPFHE S    T  WNA AN+ IL+AVI  MTV+LI+ YKY+C  +IHGWL +SS MLL +FSY++L E LK YN+PMDYITL FIMWNFGV+GM+ IHW+ PLLLQQ+YLIF++AL+AL FIKYLP +TTW VL  IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+  MY+   MA               D        +N       +  E+   P  Q +    +++EE+RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF TKEI++PF D ++S Q++I
Sbjct:   69 QETEEEE--LKYGAKHVIKLFAPVSLCMVVVVATISSVNFYSRKD-VYFIYTPFHEESPETSTKVWNAIANSFILIAVIITMTVLLIVLYKYRCYKIIHGWLIVSSLMLLSIFSYLYLEETLKAYNIPMDYITLLFIMWNFGVMGMLCIHWQGPLLLQQAYLIFVAALMALVFIKYLPEWTTWGVLGVISIWDLVAVLTPKGPLRILVETAQERNEQIFPALIYSSTYMYAYTAMATGDDSSTITTSRSSSDHGFTQDWIENHANRVAQRQLEVHDVPSGQPRTQIHQQDEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATKEIVSPFADSLASEQVFI 447          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|755890129|ref|XP_011294721.1| (PREDICTED: presenilin homolog isoform X2 [Musca domestica])

HSP 1 Score: 436.802 bits (1122), Expect = 1.405e-147
Identity = 230/456 (50.44%), Postives = 298/456 (65.35%), Query Frame = 0

Query:    5 GEEVRIRDPRRREVQE-----------------LEEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMA-------------------------------------------------DSSSDPKRPNRRRDNQRMAAESQXQELSPPPLQQQQQPP-----VEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            G E+R R    R+ +E                 +EEEE V+ +GA++VI +F PV+LCM  VV TI S+T YT  D  YL+YTPFHE SD+ GT  WNA AN+ ILL+V+ VMT++LI+ YK +C  +IHGWL LSSFMLLF+FSY++L E+L+ YN+ MDY T   I+WNFGV+GM++IHW++PL LQQ+YLIF+SAL+AL FIKYLP +T WAVLA IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+ I+Y+ +G                                                    S+ D +   R+ + Q   ++S  +  +   +  Q+  P     + E +E+RGIKLGLGDFIFYS+LVGKASSYGDW TT+ACFVAIL+GLCLTL+ LAI+RKALPALPISI FGL F  +T  I+ PFM+E+S +Q++I
Sbjct:   57 GVEIRSRGGGHRDGEENPNDGEPGPSSQTQPPTVEEEEQVLKYGAQHVIKIFAPVSLCMLVVVATINSITFYTYTD-TYLLYTPFHEQSDDKGTKLWNALANSLILLSVVVVMTIVLIVLYKKRCYRIIHGWLILSSFMLLFIFSYLYLEELLRAYNVAMDYPTTLLILWNFGVMGMIAIHWQSPLKLQQAYLIFVSALMALVFIKYLPEWTAWAVLAAISIWDLIAVLTPKGPLRILVETAQERNEQIFPALIYSSTILYTFMGTTGGPQRNNNSSGSNSPNSPHTSQTSSTSVSRQTGNTATNAEEAAGFTEEWSSNLDERVARRQIEVQASTSDSANRSTNYRTVTAQEDRPHLGSNMTEAQEERGIKLGLGDFIFYSVLVGKASSYGDWATTIACFVAILVGLCLTLVLLAIWRKALPALPISIFFGLFFCLITSVIVKPFMEELSDQQVFI 511          

BLAST of EMLSAG00000000448 vs. nr
Match: gi|1080043845|ref|XP_018563049.1| (PREDICTED: presenilin homolog [Anoplophora glabripennis])

HSP 1 Score: 434.106 bits (1115), Expect = 3.372e-147
Identity = 235/380 (61.84%), Postives = 285/380 (75.00%), Query Frame = 0

Query:   22 EEEEFVVNHGAKNVIMLFTPVTLCMAXVVXTIXSVTXYTEEDGNYLVYTPFHELSDNPGTIAWNAFANAGILLAVIAVMTVILIISYKYKCSWLIHGWLFLSSFMLLFLFSYIFLGEVLKTYNLPMDYITLAFIMWNFGVVGMMSIHWKAPLLLQQSYLIFISALLALFFIKYLPNYTTWAVLAXISLWXLFAVLAPFGPLRILVETAQERNEPIFPSLIYSAGIMYSVIGMADSSSDPK-RPNRRRDNQRMA-----------AESQXQELSPPPLQQQQQPPVEEEEEDRGIKLGLGDFIFYSILVGKASSYGDWNTTLACFVAILIGLCLTLMFLAIFRKALPALPISITFGLIFYFLTKEIITPFMDEMSSRQIYI 389
            EEEE  + +GAK+VI LF PV+LCM  VV TI SV+ Y+ +D  YLVYTPFHE S    T AW A AN+ IL+AVI +MTV+LI+ YKY+C   IHGWL +SS MLL +FSY++L E+L+ +N+PMDY TL FIMWNFGV+GM+ IHW+ PLLLQQ+YLIF++AL+AL FIKYLP +TTWAVLA IS+W L AVL P GPLRILVETAQERNE IFP+LIYS+  MY+   MA     P  R +R   +               A+ Q +    P  + + Q     EEE+RG+KLGLGDFIFYS+LVGKASSYGDWNTTLACFVAILIGLCLTL+ LAIF+KALPALPISITFGLIFYF TKEI++PF D ++S Q++I
Sbjct:   85 EEEE--LKYGAKHVIKLFAPVSLCMVVVVATISSVSFYSMKD-MYLVYTPFHEESPESSTKAWMAAANSLILMAVIVLMTVLLIVLYKYRCYKTIHGWLIISSLMLLSIFSYLYLEEILRAFNIPMDYPTLLFIMWNFGVMGMIVIHWQGPLLLQQAYLIFVAALMALVFIKYLPEWTTWAVLAVISIWDLIAVLMPKGPLRILVETAQERNEQIFPALIYSSTYMYAYTSMASGDEVPNVRTSRSSADHGFTQEWVENHADRFAQRQIEVHDVPSGRPRVQVVAASEEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATKEIVSPFADSLASEQVFI 461