BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:aph-1 "anterior pharynx defective 1" species:7227 "Drosophila melanogaster" [GO:0005886 "plasma membrane" evidence=NAS] [GO:0007219 "Notch signaling pathway" evidence=IMP] [GO:0004175 "endopeptidase activity" evidence=IMP] [GO:0005887 "integral component of plasma membrane" evidence=NAS] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] [GO:0016485 "protein processing" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0070765 "gamma-secretase complex" evidence=IPI] [GO:0005770 "late endosome" evidence=IDA] [GO:0055037 "recycling endosome" evidence=IDA] [GO:0008593 "regulation of Notch signaling pathway" evidence=IGI] InterPro:IPR009294 Pfam:PF06105 GO:GO:0043085 GO:GO:0005887 EMBL:AE014134 GO:GO:0007219 GO:GO:0005770 GO:GO:0055037 GO:GO:0004175 GO:GO:0016485 eggNOG:NOG300477 KO:K06172 OMA:FIAFGPP PANTHER:PTHR12889 GeneTree:ENSGT00390000002049 OrthoDB:EOG7TF7B1 CTD:33467 EMBL:AF508786 EMBL:AY051658 RefSeq:NP_001259963.1 RefSeq:NP_608710.1 UniGene:Dm.19771 ProteinModelPortal:Q9VQG2 BioGrid:59690 MINT:MINT-827568 STRING:7227.FBpp0077400 PaxDb:Q9VQG2 PRIDE:Q9VQG2 EnsemblMetazoa:FBtr0077716 GeneID:33467 KEGG:dme:Dmel_CG2855 FlyBase:FBgn0031458 InParanoid:Q9VQG2 PhylomeDB:Q9VQG2 SignaLink:Q9VQG2 GenomeRNAi:33467 NextBio:783710 Bgee:Q9VQG2 GO:GO:0070765 Uniprot:Q9VQG2)

HSP 1 Score: 158.303 bits (399), Expect = 2.229e-45
Identity = 94/186 (50.54%), Postives = 126/186 (67.74%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRL 186
            MT   F+G    AFG P A+F+FTIA DPVRII+L+ ++FFWL+S LISSLW+ A++PL+    FG+VFSV FQE FR ++Y +L      +  + E+  +  D  HILAYV G GFGI SG+F LVNVLAD  GPGT+G+KGG    +  FF+ SA  +L+I+L HT W VI F+A +   Y+ +
Sbjct:    1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLWY-ALIPLKEFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRV-TDNKHILAYVSGLGFGIISGMFALVNVLADMSGPGTMGLKGG----TELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHI 180          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:Aph1b "anterior pharynx defective 1b homolog (C. elegans)" species:10090 "Mus musculus" [GO:0004175 "endopeptidase activity" evidence=IGI] [GO:0006508 "proteolysis" evidence=IGI] [GO:0007219 "Notch signaling pathway" evidence=IEA] [GO:0016020 "membrane" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0016485 "protein processing" evidence=IEA] [GO:0030133 "transport vesicle" evidence=ISO] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] Reactome:REACT_99294 InterPro:IPR009294 Pfam:PF06105 MGI:MGI:3522097 GO:GO:0016021 GO:GO:0005886 GO:GO:0043085 GO:GO:0007219 Reactome:REACT_188257 GO:GO:0004175 Reactome:REACT_189085 GO:GO:0016485 eggNOG:NOG300477 HOGENOM:HOG000007541 HOVERGEN:HBG050541 KO:K06172 TreeFam:TF314362 PANTHER:PTHR12889 GeneTree:ENSGT00390000002049 OrthoDB:EOG7TF7B1 CTD:83464 OMA:FRFGYYK EMBL:AK028521 EMBL:AK049828 EMBL:AK154847 EMBL:BC079659 RefSeq:NP_808251.1 UniGene:Mm.41291 BioGrid:228950 STRING:10090.ENSMUSP00000034934 BindingDB:Q8C7N7 PhosphoSite:Q8C7N7 PRIDE:Q8C7N7 Ensembl:ENSMUST00000034934 Ensembl:ENSMUST00000168309 GeneID:208117 KEGG:mmu:208117 UCSC:uc009qfe.1 InParanoid:Q8C7N7 NextBio:372158 PRO:PR:Q8C7N7 ArrayExpress:Q8C7N7 Bgee:Q8C7N7 Genevestigator:Q8C7N7 Uniprot:Q8C7N7)

HSP 1 Score: 153.295 bits (386), Expect = 3.701e-43
Identity = 98/261 (37.55%), Postives = 142/261 (54.41%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC-HGI--FHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   A+++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R  PV      FG++ SV  QE+FR+  Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L++SLGPGT+GI G     S  FF+ SA  +L +++ H  WGV+ F  CE+ K       W     +    +     T L  Y++ +++ + +I    GI  F+   GS  SLK C   ++ D
Sbjct:    1 MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGD----SPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNK-------WYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKLCLLCQDKD 248          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:Aph1c "anterior pharynx defective 1c homolog (C. elegans)" species:10090 "Mus musculus" [GO:0001656 "metanephros development" evidence=IMP] [GO:0004175 "endopeptidase activity" evidence=IGI] [GO:0006508 "proteolysis" evidence=IGI] [GO:0007219 "Notch signaling pathway" evidence=IEA] [GO:0008233 "peptidase activity" evidence=ISA] [GO:0016020 "membrane" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=ISA] [GO:0016485 "protein processing" evidence=IGI;ISA] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] Reactome:REACT_99294 InterPro:IPR009294 Pfam:PF06105 MGI:MGI:1915568 GO:GO:0016021 GO:GO:0005886 GO:GO:0043085 GO:GO:0007219 Reactome:REACT_188257 GO:GO:0004175 Reactome:REACT_189085 GO:GO:0016485 eggNOG:NOG300477 HOGENOM:HOG000007541 HOVERGEN:HBG050541 KO:K06172 TreeFam:TF314362 GO:GO:0001656 PANTHER:PTHR12889 TCDB:9.B.47.1.1 GeneTree:ENSGT00390000002049 OrthoDB:EOG7TF7B1 EMBL:AK002310 EMBL:AK155147 EMBL:BC050923 EMBL:BC063254 RefSeq:NP_080950.1 UniGene:Mm.284229 ProteinModelPortal:Q9DCZ9 PRIDE:Q9DCZ9 Ensembl:ENSMUST00000169282 GeneID:68318 KEGG:mmu:68318 UCSC:uc009qfi.1 CTD:68318 InParanoid:Q9DCZ9 OMA:NPEEDIA ChiTaRS:Aph1c NextBio:326993 PRO:PR:Q9DCZ9 ArrayExpress:Q9DCZ9 Bgee:Q9DCZ9 Genevestigator:Q9DCZ9 Uniprot:Q9DCZ9)

HSP 1 Score: 150.599 bits (379), Expect = 3.418e-42
Identity = 98/261 (37.55%), Postives = 141/261 (54.02%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC-HGI--FHRRXGSVNSLKACFALRNGD 249
            MT   F+G    AFG   A+++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R E V      FG + SV  QE+FR+  Y LL KA   +  +   + I      +LAYV G GFGI SG+F  VN L++SLGPGT+GI G     S  FF+ SA  +L +++ H  WGV+ F  CE+ K       W     +    +     T L  Y++ +++ + +I    GI  F+   GS  SLK C   ++ D
Sbjct:    1 MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVITNNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSINPEEDI-APSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGD----SPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNK-------WYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKFCLLCQDKD 249          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:aph1b "anterior pharynx defective 1B" species:7955 "Danio rerio" [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0016485 "protein processing" evidence=IEA] [GO:0016020 "membrane" evidence=IEA] [GO:0007219 "Notch signaling pathway" evidence=IEA] InterPro:IPR009294 Pfam:PF06105 ZFIN:ZDB-GENE-031118-31 GO:GO:0016021 GO:GO:0043085 GO:GO:0007219 GO:GO:0016485 eggNOG:NOG300477 HOGENOM:HOG000007541 HOVERGEN:HBG050541 KO:K06172 TreeFam:TF314362 PANTHER:PTHR12889 GeneTree:ENSGT00390000002049 OrthoDB:EOG7TF7B1 EMBL:AF512428 EMBL:AY423036 EMBL:BC071492 RefSeq:NP_956409.1 UniGene:Dr.78326 STRING:7955.ENSDARP00000011743 PRIDE:Q8JHE9 Ensembl:ENSDART00000008096 GeneID:386808 KEGG:dre:386808 CTD:83464 InParanoid:Q8JHE9 OMA:FRFGYYK NextBio:20814026 PRO:PR:Q8JHE9 Bgee:Q8JHE9 Uniprot:Q8JHE9)

HSP 1 Score: 150.599 bits (379), Expect = 4.312e-42
Identity = 106/262 (40.46%), Postives = 146/262 (55.73%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEP---------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTEND--PIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPI--TTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGD 249
            MT   F+G    AFG   A+F+FTIA DP+R+I L+  +FFWL+S L+SSL WF  V + ++          +FG+V SV  QE FR   Y LL KA   +  L++ D  PI   +   LAYV G GFG  SG F +VN+L+DSLGPGT+GI G     S+H+FI SA  +LAI+L H  WGV+ F ACE +++  L  V A H  +S +   +     + + TY    V+      C G      GS+ +LK C   ++ D
Sbjct:    1 MTVAVFFGCTFIAFGPAIALFMFTIARDPLRVIFLIAGAFFWLVSLLLSSLVWFITVQISNKNSATQQRGLLIFGVVLSVLLQEAFRYGYYRLLKKANEGLLALSQEDTMPISMRQ---LAYVSGLGFGFMSGAFSVVNILSDSLGPGTVGIHGE----SQHYFISSAFMTLAIILLHMFWGVVFFEACERQRWWALGAVVASHLVVSCLTFVNPHYQGSLIPTYIILSVMAVWAYLCAG------GSLRNLKLCLTCKDKD 249          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:LOC691658 "similar to anterior pharynx defective 1b homolog" species:10116 "Rattus norvegicus" [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0016485 "protein processing" evidence=IEA] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] InterPro:IPR009294 Pfam:PF06105 RGD:1597236 GO:GO:0016021 GO:GO:0043085 GO:GO:0016485 KO:K06172 PANTHER:PTHR12889 GeneTree:ENSGT00390000002049 OrthoDB:EOG7TF7B1 OMA:SILWEST EMBL:AABR06055437 RefSeq:XP_003750580.1 Ensembl:ENSRNOT00000024207 GeneID:691658 KEGG:rno:691658 CTD:691658 NextBio:35566915 Uniprot:D3ZEJ1)

HSP 1 Score: 147.902 bits (372), Expect = 3.623e-41
Identity = 95/261 (36.40%), Postives = 142/261 (54.41%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC-HGI--FHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   ++++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R  PV      FG++ SV  QE+FR+  Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L+++LGPGT+GI G     S  FF+ SA  +L I++ H  WG++ F  CE+ K       W +   +    +     T L  +++ +++ + +I    GI  F    GS  SLK C   ++ D
Sbjct:    1 MTAAVFFGCAFIAFGPALSLYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKANEGLKSINPEET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGD----SPQFFLNSAFMTLVIIMLHVFWGIVFFDGCEKNK-------WYILLTVLLTHLLVSTQTLLSPHYEVNLVTAYIIMVLMGIWAFCVAGGSRRSLKLCLLCQDKD 248          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:Aph1b "Anterior pharynx defective 1 homolog B (C. elegans)" species:10116 "Rattus norvegicus" [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0016485 "protein processing" evidence=IEA] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] InterPro:IPR009294 Pfam:PF06105 RGD:1562468 RGD:6494045 GO:GO:0016021 GO:GO:0043085 GO:GO:0016485 eggNOG:NOG300477 HOGENOM:HOG000007541 HOVERGEN:HBG050541 KO:K06172 TreeFam:TF314362 PANTHER:PTHR12889 GeneTree:ENSGT00390000002049 OrthoDB:EOG7TF7B1 CTD:83464 OMA:FRFGYYK EMBL:AABR06055646 EMBL:BC166592 EMBL:DQ672552 RefSeq:NP_001040555.1 UniGene:Rn.103390 STRING:10116.ENSRNOP00000024176 Ensembl:ENSRNOT00000024176 GeneID:300802 KEGG:rno:300802 InParanoid:Q0PY50 NextBio:647547 Genevestigator:Q0PY50 Uniprot:Q0PY50)

HSP 1 Score: 147.517 bits (371), Expect = 4.666e-41
Identity = 96/261 (36.78%), Postives = 142/261 (54.41%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC-HGI--FHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   A+++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R  PV      FG++ SV  QE+FR+  Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L+++LGPGT+GI G     S  FF+ SA  +L I++ H  WG++ F  CE+ K       W +   +    +     T L  +++ +++ + +I    GI  F    GS  SLK C   ++ D
Sbjct:    1 MTAPVFFGCAFIAFGPALALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKASEGLKSINPEET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGD----SPQFFLNSAFMTLVIIMLHVFWGIVFFDGCEKNK-------WYILLTVLLTHLLVSTQTLLSPHYEVNLVTAYIIMVLMGIWAFCVAGGSRRSLKLCLLCQDKD 248          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:Aph1b "APH1B gamma secretase subunit" species:10116 "Rattus norvegicus" [GO:0004175 "endopeptidase activity" evidence=ISO] [GO:0008233 "peptidase activity" evidence=ISO] [GO:0016021 "integral component of membrane" evidence=IEA;ISO] [GO:0016485 "protein processing" evidence=IEA;ISO] [GO:0030133 "transport vesicle" evidence=ISO] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] InterPro:IPR009294 Pfam:PF06105 RGD:1562468 RGD:6494045 GO:GO:0016021 GO:GO:0043085 GO:GO:0016485 eggNOG:NOG300477 HOGENOM:HOG000007541 HOVERGEN:HBG050541 KO:K06172 TreeFam:TF314362 PANTHER:PTHR12889 GeneTree:ENSGT00390000002049 OrthoDB:EOG7TF7B1 CTD:83464 OMA:FRFGYYK EMBL:AABR06055646 EMBL:BC166592 EMBL:DQ672552 RefSeq:NP_001040555.1 UniGene:Rn.103390 STRING:10116.ENSRNOP00000024176 Ensembl:ENSRNOT00000024176 GeneID:300802 KEGG:rno:300802 InParanoid:Q0PY50 NextBio:647547 Genevestigator:Q0PY50 Uniprot:Q0PY50)

HSP 1 Score: 147.517 bits (371), Expect = 4.666e-41
Identity = 96/261 (36.78%), Postives = 142/261 (54.41%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC-HGI--FHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   A+++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R  PV      FG++ SV  QE+FR+  Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L+++LGPGT+GI G     S  FF+ SA  +L I++ H  WG++ F  CE+ K       W +   +    +     T L  +++ +++ + +I    GI  F    GS  SLK C   ++ D
Sbjct:    1 MTAPVFFGCAFIAFGPALALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKASEGLKSINPEET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGD----SPQFFLNSAFMTLVIIMLHVFWGIVFFDGCEKNK-------WYILLTVLLTHLLVSTQTLLSPHYEVNLVTAYIIMVLMGIWAFCVAGGSRRSLKLCLLCQDKD 248          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:APH1B "Gamma-secretase subunit APH-1B" species:9606 "Homo sapiens" [GO:0005515 "protein binding" evidence=IPI] [GO:0005886 "plasma membrane" evidence=TAS] [GO:0007219 "Notch signaling pathway" evidence=TAS] [GO:0007220 "Notch receptor processing" evidence=TAS] [GO:0008233 "peptidase activity" evidence=IDA] [GO:0016021 "integral component of membrane" evidence=IDA] [GO:0016485 "protein processing" evidence=IDA] [GO:0030133 "transport vesicle" evidence=IDA] [GO:0031293 "membrane protein intracellular domain proteolysis" evidence=TAS] [GO:0043065 "positive regulation of apoptotic process" evidence=TAS] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] [GO:0048011 "neurotrophin TRK receptor signaling pathway" evidence=TAS] [GO:0097190 "apoptotic signaling pathway" evidence=TAS] Reactome:REACT_691 InterPro:IPR009294 Pfam:PF06105 GO:GO:0016021 GO:GO:0005886 GO:GO:0043085 Reactome:REACT_111102 Reactome:REACT_116125 GO:GO:0048011 GO:GO:0008233 GO:GO:0007219 GO:GO:0097190 GO:GO:0043065 GO:GO:0007220 GO:GO:0031293 GO:GO:0030133 GO:GO:0016485 EMBL:CH471082 ChEMBL:CHEMBL2094135 eggNOG:NOG300477 HOGENOM:HOG000007541 HOVERGEN:HBG050541 KO:K06172 TreeFam:TF314362 PANTHER:PTHR12889 CTD:83464 OMA:FRFGYYK EMBL:AF508794 EMBL:AB189172 EMBL:AL136671 EMBL:AY358698 EMBL:AK291204 EMBL:AC016207 EMBL:BC020905 RefSeq:NP_001139118.1 RefSeq:NP_112591.2 UniGene:Hs.511703 ProteinModelPortal:Q8WW43 BioGrid:123659 IntAct:Q8WW43 MINT:MINT-4721718 STRING:9606.ENSP00000261879 BindingDB:Q8WW43 PhosphoSite:Q8WW43 DMDM:61252592 PaxDb:Q8WW43 PRIDE:Q8WW43 DNASU:83464 Ensembl:ENST00000261879 Ensembl:ENST00000380343 GeneID:83464 KEGG:hsa:83464 UCSC:uc002ama.3 UCSC:uc002amb.3 GeneCards:GC15P064873 HGNC:HGNC:24080 MIM:607630 neXtProt:NX_Q8WW43 PharmGKB:PA142672600 InParanoid:Q8WW43 PhylomeDB:Q8WW43 SignaLink:Q8WW43 GenomeRNAi:83464 NextBio:72393 PRO:PR:Q8WW43 ArrayExpress:Q8WW43 Bgee:Q8WW43 CleanEx:HS_APH1B Genevestigator:Q8WW43 Uniprot:Q8WW43)

HSP 1 Score: 147.517 bits (371), Expect = 5.762e-41
Identity = 96/261 (36.78%), Postives = 138/261 (52.87%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWF---AVVPLRHEP------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC---HGIFHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   A+++FTIA +P+RII L+  +FFWL+S LISSL WF    ++  +  P      +FG   SV  QE+FR   Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L+DSLGPGT+GI G     S  FF++SA  +L I+L H  WG++ F  CE+KK       W +   +    +     T + +Y+  ++ ++ +I        F    GS  SLK C   ++ +
Sbjct:    1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGD----SPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKK-------WGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKN 248          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:LOC431243 "Uncharacterized protein" species:9031 "Gallus gallus" [GO:0001656 "metanephros development" evidence=IEA] [GO:0004175 "endopeptidase activity" evidence=IEA] [GO:0005783 "endoplasmic reticulum" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IEA] [GO:0006509 "membrane protein ectodomain proteolysis" evidence=IEA] [GO:0007220 "Notch receptor processing" evidence=IEA] [GO:0031293 "membrane protein intracellular domain proteolysis" evidence=IEA] [GO:0042987 "amyloid precursor protein catabolic process" evidence=IEA] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] InterPro:IPR009294 Pfam:PF06105 GO:GO:0016021 GO:GO:0043085 GO:GO:0016485 KO:K06172 PANTHER:PTHR12889 GeneTree:ENSGT00390000002049 EMBL:AADN03008353 RefSeq:XP_428797.3 Ensembl:ENSGALT00000043142 GeneID:431243 KEGG:gga:431243 Uniprot:R4GFW9)

HSP 1 Score: 145.976 bits (367), Expect = 2.774e-40
Identity = 100/266 (37.59%), Postives = 145/266 (54.51%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEP---------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKP---HILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVID-CHGI--FHRRXGSVNSLKACFALRNGDSS 251
            M A  F+G    AFG   A+ + T+A +P+R+I+LV  +FFWL+S L++SL WF  V L  +          VFG   SV  QE FR   + LL KA   ++ ++E+    G  P     +AYV G  FGI SG+F ++N+LADS+GPG +GI G     S ++FI SA  ++A+VL HT WGVI F ACE+++Y  L  V   H   SG       +T L  ++   ++   +I  C GI  F    GS +++  C + +  D S
Sbjct:    1 MGAAVFFGCAGIAFGPALALVLLTVAAEPLRVIILVAGAFFWLVSLLLASLIWFISVHLSDQGNARLQYGLLVFGAAVSVLLQEAFRFAYFKLLKKADEGLATISED----GRSPISLKQMAYVSGLSFGIISGVFSVINILADSIGPGIVGIHGD----SPYYFITSAFLTMAVVLLHTFWGVIFFDACEKRRYWCLGLVVISHLVTSG-------LTFLNPWYVASLVPIYIITFCMGIWAFFTAGGSFHNILKCLSCKQEDDS 251          

BLAST of EMLSAG00000000913 vs. GO
Match: - (symbol:LOC100911293 "gamma-secretase subunit APH-1B-like" species:10116 "Rattus norvegicus" [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0016485 "protein processing" evidence=IEA] [GO:0043085 "positive regulation of catalytic activity" evidence=IEA] REFSEQ:XM_003750537 Ncbi:XP_003750585)

HSP 1 Score: 143.665 bits (361), Expect = 5.864e-40
Identity = 82/192 (42.71%), Postives = 116/192 (60.42%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            MTA  F+G    AFG   A+++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R  PV      FG++ SV  QE+FR+  Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L+++LGPGT+GI G     S  FF+ SA  +L I++ H  WG++ F  CE+ K+
Sbjct:    1 MTAPVFFGCAFIAFGPALALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKASEGLKSINPEET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGD----SPQFFLNSAFMTLVIIMLHVFWGIVFFDGCEKNKW 186          

BLAST of EMLSAG00000000913 vs. C. finmarchicus
Match: gi|592767245|gb|GAXK01187323.1| (TSA: Calanus finmarchicus comp11439_c0_seq2 transcribed RNA sequence)

HSP 1 Score: 147.902 bits (372), Expect = 4.987e-41
Identity = 108/185 (58.38%), Postives = 139/185 (75.14%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRXXXXXXXXXXXXXXXXXXXXXXXAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDP--IFGDKPHILAYVXXXXXXXXXXXXXXVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            MTA+TF+G  LTA+G P A+F+ TI+ DPV+II+L+LS+FFWL+S L+S++ W AVVPL+ E  FGLVFSV FQE+FR L+YLLL KA +++ KLTE +   IF +K HILAYV+G GFG+ SG F LVNVLA SLGPGTLG  G       +FFI SA+ +L +VL HT+WGVI FS+ +   Y
Sbjct:   40 MTAYTFFGCALTAYGTPLALFLLTISSDPVKIIILILSAFFWLLSLLLSAILWTAVVPLKEELAFGLVFSVLFQELFRFLIYLLLDKADTYLKKLTETEETQIFANK-HILAYVVGLGFGLMSGAFSLVNVLAASLGPGTLGFNGEP----HNFFIVSAVMTLCMVLLHTSWGVIFFSSLDTGTY 579          

BLAST of EMLSAG00000000913 vs. C. finmarchicus
Match: gi|592767246|gb|GAXK01187322.1| (TSA: Calanus finmarchicus comp11439_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 147.902 bits (372), Expect = 5.814e-41
Identity = 108/185 (58.38%), Postives = 139/185 (75.14%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRXXXXXXXXXXXXXXXXXXXXXXXAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDP--IFGDKPHILAYVXXXXXXXXXXXXXXVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            MTA+TF+G  LTA+G P A+F+ TI+ DPV+II+L+LS+FFWL+S L+S++ W AVVPL+ E  FGLVFSV FQE+FR L+YLLL KA +++ KLTE +   IF +K HILAYV+G GFG+ SG F LVNVLA SLGPGTLG  G       +FFI SA+ +L +VL HT+WGVI FS+ +   Y
Sbjct:   40 MTAYTFFGCALTAYGTPLALFLLTISSDPVKIIILILSAFFWLLSLLLSAILWTAVVPLKEELAFGLVFSVLFQELFRFLIYLLLDKADTYLKKLTETEETQIFANK-HILAYVVGLGFGLMSGAFSLVNVLAASLGPGTLGFNGEP----HNFFIVSAVMTLCMVLLHTSWGVIFFSSLDTGTY 579          

BLAST of EMLSAG00000000913 vs. C. finmarchicus
Match: gi|592767241|gb|GAXK01187327.1| (TSA: Calanus finmarchicus comp11439_c0_seq6 transcribed RNA sequence)

HSP 1 Score: 73.559 bits (179), Expect = 1.810e-14
Identity = 53/99 (53.54%), Postives = 68/99 (68.69%), Query Frame = 0

Query:   87 KARSFMSKLTENDP--IFGDKPHILAYVXXXXXXXXXXXXXXVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            +A +++ KLTE +   IF +K HILAYV+G GFG+ SG F LVNVLA SLGPGTLG  G       +FFI SA+ +L +VL HT+WGVI FS+ +   Y
Sbjct:  219 QADTYLKKLTETEETQIFANK-HILAYVVGLGFGLMSGAFSLVNVLAASLGPGTLGFNGEP----HNFFIVSAVMTLCMVLLHTSWGVIFFSSLDTGTY 500          

BLAST of EMLSAG00000000913 vs. C. finmarchicus
Match: gi|592767243|gb|GAXK01187325.1| (TSA: Calanus finmarchicus comp11439_c0_seq4 transcribed RNA sequence)

HSP 1 Score: 73.559 bits (179), Expect = 1.818e-14
Identity = 53/99 (53.54%), Postives = 68/99 (68.69%), Query Frame = 0

Query:   87 KARSFMSKLTENDP--IFGDKPHILAYVXXXXXXXXXXXXXXVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            +A +++ KLTE +   IF +K HILAYV+G GFG+ SG F LVNVLA SLGPGTLG  G       +FFI SA+ +L +VL HT+WGVI FS+ +   Y
Sbjct:  219 QADTYLKKLTETEETQIFANK-HILAYVVGLGFGLMSGAFSLVNVLAASLGPGTLGFNGEP----HNFFIVSAVMTLCMVLLHTSWGVIFFSSLDTGTY 500          

BLAST of EMLSAG00000000913 vs. C. finmarchicus
Match: gi|592767242|gb|GAXK01187326.1| (TSA: Calanus finmarchicus comp11439_c0_seq5 transcribed RNA sequence)

HSP 1 Score: 73.559 bits (179), Expect = 1.900e-14
Identity = 53/99 (53.54%), Postives = 68/99 (68.69%), Query Frame = 0

Query:   87 KARSFMSKLTENDP--IFGDKPHILAYVXXXXXXXXXXXXXXVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            +A +++ KLTE +   IF +K HILAYV+G GFG+ SG F LVNVLA SLGPGTLG  G       +FFI SA+ +L +VL HT+WGVI FS+ +   Y
Sbjct:  232 QADTYLKKLTETEETQIFANK-HILAYVVGLGFGLMSGAFSLVNVLAASLGPGTLGFNGEP----HNFFIVSAVMTLCMVLLHTSWGVIFFSSLDTGTY 513          

BLAST of EMLSAG00000000913 vs. C. finmarchicus
Match: gi|592767244|gb|GAXK01187324.1| (TSA: Calanus finmarchicus comp11439_c0_seq3 transcribed RNA sequence)

HSP 1 Score: 73.559 bits (179), Expect = 1.906e-14
Identity = 53/99 (53.54%), Postives = 68/99 (68.69%), Query Frame = 0

Query:   87 KARSFMSKLTENDP--IFGDKPHILAYVXXXXXXXXXXXXXXVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            +A +++ KLTE +   IF +K HILAYV+G GFG+ SG F LVNVLA SLGPGTLG  G       +FFI SA+ +L +VL HT+WGVI FS+ +   Y
Sbjct:  232 QADTYLKKLTETEETQIFANK-HILAYVVGLGFGLMSGAFSLVNVLAASLGPGTLGFNGEP----HNFFIVSAVMTLCMVLLHTSWGVIFFSSLDTGTY 513          

BLAST of EMLSAG00000000913 vs. L. salmonis peptides
Match: EMLSAP00000000913 (pep:novel supercontig:LSalAtl2s:LSalAtl2s115:30103:30983:-1 gene:EMLSAG00000000913 transcript:EMLSAT00000000913 description:"maker-LSalAtl2s115-augustus-gene-0.5")

HSP 1 Score: 509.99 bits (1312), Expect = 0.000e+0
Identity = 257/257 (100.00%), Postives = 257/257 (100.00%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGDSSTNVFVR 257
            MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGDSSTNVFVR
Sbjct:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGDSSTNVFVR 257          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|37077998|sp|Q9VQG2.1|APH1_DROME (RecName: Full=Gamma-secretase subunit Aph-1; AltName: Full=Presenilin-stabilization factor)

HSP 1 Score: 158.303 bits (399), Expect = 1.150e-46
Identity = 94/186 (50.54%), Postives = 126/186 (67.74%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRL 186
            MT   F+G    AFG P A+F+FTIA DPVRII+L+ ++FFWL+S LISSLW+ A++PL+    FG+VFSV FQE FR ++Y +L      +  + E+  +  D  HILAYV G GFGI SG+F LVNVLAD  GPGT+G+KGG    +  FF+ SA  +L+I+L HT W VI F+A +   Y+ +
Sbjct:    1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLWY-ALIPLKEFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRV-TDNKHILAYVSGLGFGIISGMFALVNVLADMSGPGTMGLKGG----TELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHI 180          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|37077156|sp|Q8C7N7.1|APH1B_MOUSE (RecName: Full=Gamma-secretase subunit APH-1B; Short=APH-1b; AltName: Full=Aph-1beta)

HSP 1 Score: 153.295 bits (386), Expect = 2.127e-44
Identity = 98/261 (37.55%), Postives = 142/261 (54.41%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC-HGI--FHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   A+++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R  PV      FG++ SV  QE+FR+  Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L++SLGPGT+GI G     S  FF+ SA  +L +++ H  WGV+ F  CE+ K       W     +    +     T L  Y++ +++ + +I    GI  F+   GS  SLK C   ++ D
Sbjct:    1 MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGD----SPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNK-------WYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKLCLLCQDKD 248          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|37077773|sp|Q9DCZ9.1|APH1C_MOUSE (RecName: Full=Putative gamma-secretase subunit APH-1C)

HSP 1 Score: 150.599 bits (379), Expect = 2.040e-43
Identity = 98/261 (37.55%), Postives = 141/261 (54.02%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPL---RHEPV------FGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC-HGI--FHRRXGSVNSLKACFALRNGD 249
            MT   F+G    AFG   A+++FTIA DP+R+I L+  +FFWL+S L+SS++WF V  +   R E V      FG + SV  QE+FR+  Y LL KA   +  +   + I      +LAYV G GFGI SG+F  VN L++SLGPGT+GI G     S  FF+ SA  +L +++ H  WGV+ F  CE+ K       W     +    +     T L  Y++ +++ + +I    GI  F+   GS  SLK C   ++ D
Sbjct:    1 MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVITNNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSINPEEDI-APSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGD----SPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNK-------WYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKFCLLCQDKD 249          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|37077309|sp|Q8JHE9.1|APH1B_DANRE (RecName: Full=Gamma-secretase subunit Aph-1b; AltName: Full=Anterior-pharynx-defective protein 1b)

HSP 1 Score: 150.599 bits (379), Expect = 2.583e-43
Identity = 106/262 (40.46%), Postives = 146/262 (55.73%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEP---------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTEND--PIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPI--TTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGD 249
            MT   F+G    AFG   A+F+FTIA DP+R+I L+  +FFWL+S L+SSL WF  V + ++          +FG+V SV  QE FR   Y LL KA   +  L++ D  PI   +   LAYV G GFG  SG F +VN+L+DSLGPGT+GI G     S+H+FI SA  +LAI+L H  WGV+ F ACE +++  L  V A H  +S +   +     + + TY    V+      C G      GS+ +LK C   ++ D
Sbjct:    1 MTVAVFFGCTFIAFGPAIALFMFTIARDPLRVIFLIAGAFFWLVSLLLSSLVWFITVQISNKNSATQQRGLLIFGVVLSVLLQEAFRYGYYRLLKKANEGLLALSQEDTMPISMRQ---LAYVSGLGFGFMSGAFSVVNILSDSLGPGTVGIHGE----SQHYFISSAFMTLAIILLHMFWGVVFFEACERQRWWALGAVVASHLVVSCLTFVNPHYQGSLIPTYIILSVMAVWAYLCAG------GSLRNLKLCLTCKDKD 249          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|71152230|sp|Q5RDM3.1|APH1B_PONAB (RecName: Full=Gamma-secretase subunit APH-1B; Short=APH-1b; AltName: Full=Aph-1beta)

HSP 1 Score: 149.058 bits (375), Expect = 7.279e-43
Identity = 97/261 (37.16%), Postives = 138/261 (52.87%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWF---AVVPLRHEP------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC---HGIFHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   A+++FTIA +P+RII L+  +FFWL+S LISSL WF    ++  +  P      +FG   SV  QE+FR   Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L+DSLGPGT+GI G     S  FF++SA  +L I+L H  WG++ F  CE+KK       W +   +    +     T + +Y+  ++ ++ +I        F    GS  SLK C   ++ D
Sbjct:    1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGTFVSVYIQEMFRFAYYRLLKKASEGLKSINPGET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGD----SPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKK-------WGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKD 248          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|61252592|sp|Q8WW43.3|APH1B_HUMAN (RecName: Full=Gamma-secretase subunit APH-1B; Short=APH-1b; AltName: Full=Aph-1beta; AltName: Full=Presenilin-stabilization factor-like)

HSP 1 Score: 147.517 bits (371), Expect = 3.600e-42
Identity = 96/261 (36.78%), Postives = 138/261 (52.87%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWF---AVVPLRHEP------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDC---HGIFHRRXGSVNSLKACFALRNGD 249
            MTA  F+G    AFG   A+++FTIA +P+RII L+  +FFWL+S LISSL WF    ++  +  P      +FG   SV  QE+FR   Y LL KA   +  +   +        +LAYV G GFGI SG+F  VN L+DSLGPGT+GI G     S  FF++SA  +L I+L H  WG++ F  CE+KK       W +   +    +     T + +Y+  ++ ++ +I        F    GS  SLK C   ++ +
Sbjct:    1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGET--APSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGD----SPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKK-------WGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKN 248          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|37077707|sp|Q96BI3.1|APH1A_HUMAN (RecName: Full=Gamma-secretase subunit APH-1A; Short=APH-1a; AltName: Full=Aph-1alpha; AltName: Full=Presenilin-stabilization factor)

HSP 1 Score: 144.436 bits (363), Expect = 5.749e-41
Identity = 87/211 (41.23%), Postives = 123/211 (58.29%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEP---------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKP---HILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGI 199
            M A  F+G    AFG   A+F+ T+A DP+R+I+LV  +FFWL+S L++S+ WF +V +             +FG   SV  QE+FR   Y LL KA   ++ L+E+    G  P     +AYV G  FGI SG+F ++N+LAD+LGPG +GI G     S ++F+ SA  + AI+L HT WGV+ F ACE ++Y  L  V   H   SG+
Sbjct:    1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSED----GRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGD----SPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGL 203          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|37077149|sp|Q8BVF7.2|APH1A_MOUSE (RecName: Full=Gamma-secretase subunit APH-1A; Short=APH-1a; AltName: Full=Aph-1alpha)

HSP 1 Score: 144.05 bits (362), Expect = 8.272e-41
Identity = 95/266 (35.71%), Postives = 147/266 (55.26%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEP---------VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKP---HILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDCH-GI--FHRRXGSVNSLKACFALRNGDSS 251
            M A  F+G    AFG   ++F+ T+A DP+R+I+LV  +FFWL+S L++S+ WF +V +             +FG   SV  QE+FR   Y LL KA   ++ L+E+    G  P     +AYV G  FGI SG+F ++N+LAD+LGPG +GI G     S ++F+ SA  + AI+L HT WGV+ F ACE ++Y      WA+   +   ++TS  +T L  +++  +L    +    G+  F    GS+ S++   + R  + S
Sbjct:    1 MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSED----GRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGD----SPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRY------WALGLVVGSHLLTSG-LTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLSCRRQEDS 251          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|37076812|sp|O45876.1|APH1_CAEEL (RecName: Full=Gamma-secretase subunit aph-1; AltName: Full=Anterior-pharynx-defective protein 1; AltName: Full=Presenilin enhancer protein 1)

HSP 1 Score: 89.7373 bits (221), Expect = 6.846e-20
Identity = 60/187 (32.09%), Postives = 95/187 (50.80%), Query Frame = 0

Query:   10 FLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEP-VFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPI--------FGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLG----IKGGDFGVSRHFFIFSALFSLAIVLC---HTAWGVIAFSACEE 180
            ++ +F    A+F   IA DPVRIIL  L SFFWL+S L SSL W  +  +  +  +  L   +  QE+ R+  ++LL KA+  ++K+T    I          +  H+LA V G G G+ S LF  +N  A   GPGT+G    +K G+   +R        ++L+ +L    H  W ++ + +C +
Sbjct:   10 YIASFSPSIALFCSFIAHDPVRIILFFLGSFFWLVSLLFSSLAWLGLSTVLPDTFLLSLTVCIIAQELSRVAYFMLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFAIFSGPGTIGLPNALKTGEIDTNRAGKYLPLCYTLSAILLTLFHVTWTIMVWDSCHK 196          

BLAST of EMLSAG00000000913 vs. SwissProt
Match: gi|74859324|sp|Q55FS3.1|APH1_DICDI (RecName: Full=Gamma-secretase subunit Aph-1)

HSP 1 Score: 65.4698 bits (158), Expect = 3.426e-11
Identity = 38/102 (37.25%), Postives = 55/102 (53.92%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRIL---LYLLLFKARSFMSKLTEND 99
            MT   F+G     F    A F   IA +   +IL +  SFFWL+S LI+++WW+ + P+R    F + FSV FQEIFR +   LY   F  R  ++++ E  
Sbjct:    1 MTQVLFYGCLFITFSPILAFFFMVIAKNSQLVILTIGGSFFWLVSILIAAIWWYIIPPMREHWWFIISFSVLFQEIFRYIFFRLYSYGFNDRPSLNQIKETQ 102          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: XP_006560654.1 (PREDICTED: gamma-secretase subunit Aph-1 [Apis mellifera])

HSP 1 Score: 169.859 bits (429), Expect = 2.355e-51
Identity = 103/216 (47.69%), Postives = 139/216 (64.35%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGI----VITSKPITTLRTY 212
            MT   F+G    AFG P AMF FT+A +P+RII+L+ S+FFWLIS L+SS+ W+AVVPL++   FGLVFSV FQE FR LLY +L KA   + K+T       D  H+ AYV G GFG  SG+F LVNVLAD++GPGT+G++ G    + +FF+ SA  +L  +L HT WGV+ FSA + K + +++ V   H  +S +    V  +   TTL  Y
Sbjct:    1 MTVMDFFGCAFLAFGPPLAMFTFTVAAEPIRIIILIASAFFWLISLLLSSILWYAVVPLQNHLAFGLVFSVLFQEAFRYLLYWVLRKAERGLDKVTTTH--VADSRHVFAYVCGLGFGFMSGVFALVNVLADAVGPGTMGLRQG----TEYFFVISAATTLCFILLHTFWGVVFFSALDRKNWGQVIWVVGSHLFVSCMTLLNVKEAYVATTLSAY 210          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: EFX71350.1 (hypothetical protein DAPPUDRAFT_308872 [Daphnia pulex])

HSP 1 Score: 165.236 bits (417), Expect = 1.848e-49
Identity = 105/197 (53.30%), Postives = 129/197 (65.48%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALS 197
            M    F+G    AFG P AMF+ TIA DP+RII+L+ S+FFWL+S L SSL W   V L    V G++FSV FQE+FR L+YLLL KA   + KLTE+D       +ILAYV G GFGI SG F LVNVLAD+ GPGT+G+ G     S  FF+ SAL +L  +L HTAWGV+ F A ++KKYL LV V   H  +S
Sbjct:    1 MALLEFFGCAFLAFGPPLAMFLLTIAKDPIRIIILIASAFFWLLSLLTSSLLWLVAVTLHSPIVVGVIFSVLFQELFRYLIYLLLRKAEVGLKKLTESDTAIITNKNILAYVSGLGFGIISGTFSLVNVLADATGPGTVGLHGD----SNLFFLTSALLTLCFILLHTAWGVLFFHALDKKKYLALVWVVMSHLLVS 193          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: gb|EFA04103.1| (Gamma-secretase subunit Aph-1-like Protein [Tribolium castaneum])

HSP 1 Score: 164.081 bits (414), Expect = 4.042e-49
Identity = 113/251 (45.02%), Postives = 150/251 (59.76%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITS---KPITTLRTYFDHDVLNSNVIDCHGIFHRRX--GSVNSLKACFALR 246
            MT   F+G    AFG P AMF+FTIA DPVRII+L+ ++FFWL+S L+SSLWW+ VVPLR +  FG+VFSV FQE FR ++Y +L KA + + K+T++     +  HILAYV G GFGI SG F LVN+LAD++GPGT+G+KGG+      FF+ SA   L   L HT WGVI F+A +      +  V   H   S I + +    P  TL   + + VL        G+   R   GS  S K+C   +
Sbjct:    1 MTLVEFFGCTFLAFGPPFAMFVFTIAHDPVRIIILIAAAFFWLVSLLLSSLWWYIVVPLRQDLAFGVVFSVFFQETFRYIIYKILRKAENGLKKITDDSTQLIENKHILAYVSGLGFGIISGAFSLVNILADAVGPGTMGLKGGN----EMFFLTSAATGLCFTLLHTFWGVIFFNALDNSNKCYVGVVVVSHLLSSCITLLNFKVGPAGTLIPLYFNLVL-------MGLMAYRVAGGSYASFKSCITFK 240          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: EAA14158.3 (AGAP009816-PA [Anopheles gambiae str. PEST])

HSP 1 Score: 162.54 bits (410), Expect = 1.465e-48
Identity = 94/193 (48.70%), Postives = 121/193 (62.69%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMH 193
            MT   F+G    AFG P AMF  TIA DP+RII+L+ +SFFWL+S L+SS  W A  P+  +  FGL+ SV  QE FR L+Y +L K  S + ++T+   I  D  HIL+Y  G GFGI SG F LVN+LADS+GP T+G+K      S  F + SA  SLA++L HT W VI F+AC+ K Y  +  V A H
Sbjct:    1 MTVVEFFGCSFLAFGPPVAMFALTIAHDPIRIIILIAASFFWLVSLLLSSTVWLAFHPVTSKVTFGLICSVFIQEGFRYLMYKVLRKTESGLQEVTDIVRI-ADYRHILSYASGLGFGIISGAFSLVNILADSVGPATVGLKAA----SDIFMLISAAQSLAMILLHTFWSVIFFNACDVKNYYHIGYVVASH 188          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: AGB92500.1 (anterior pharynx defective 1, isoform B [Drosophila melanogaster])

HSP 1 Score: 158.303 bits (399), Expect = 5.573e-47
Identity = 94/186 (50.54%), Postives = 126/186 (67.74%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRL 186
            MT   F+G    AFG P A+F+FTIA DPVRII+L+ ++FFWL+S LISSLW+ A++PL+    FG+VFSV FQE FR ++Y +L      +  + E+  +  D  HILAYV G GFGI SG+F LVNVLAD  GPGT+G+KGG    +  FF+ SA  +L+I+L HT W VI F+A +   Y+ +
Sbjct:    1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLWY-ALIPLKEFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRV-TDNKHILAYVSGLGFGIISGMFALVNVLADMSGPGTMGLKGG----TELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHI 180          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: AAF51212.1 (anterior pharynx defective 1, isoform A [Drosophila melanogaster])

HSP 1 Score: 158.303 bits (399), Expect = 5.573e-47
Identity = 94/186 (50.54%), Postives = 126/186 (67.74%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRL 186
            MT   F+G    AFG P A+F+FTIA DPVRII+L+ ++FFWL+S LISSLW+ A++PL+    FG+VFSV FQE FR ++Y +L      +  + E+  +  D  HILAYV G GFGI SG+F LVNVLAD  GPGT+G+KGG    +  FF+ SA  +L+I+L HT W VI F+A +   Y+ +
Sbjct:    1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLWY-ALIPLKEFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRV-TDNKHILAYVSGLGFGIISGMFALVNVLADMSGPGTMGLKGG----TELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHI 180          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: gb|KFM64181.1| (Gamma-secretase subunit Aph-1, partial [Stegodyphus mimosarum])

HSP 1 Score: 158.303 bits (399), Expect = 7.947e-47
Identity = 105/254 (41.34%), Postives = 146/254 (57.48%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTE---NDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDCHGI--FHRRXGSVNSLKACFALRNGD 249
            MT   F+G  + AFG  +AM   TIA DP+RII+L+ ++FFWL+S L+SS+ W  VVPLR +  FG+VFSV FQEIFR   Y LL KA   + K+ E   +  +       LAYV G GFG+ SGLF L+NVLADS+GPGT+G+    +G S  FF+ SA  +LA  L HT WGV+ F A + + Y ++  V   H  +S + + ++     R Y    +    V    G+  +    GS  SL A  + +N +
Sbjct:    1 MTVMEFFGCAMIAFGPSAAMLAITIARDPIRIIILISAAFFWLLSLLLSSILWNVVVPLRKQLAFGVVFSVIFQEIFRFCFYKLLRKAEVGLKKVQEVGADGAVVSSNRSTLAYVAGLGFGLMSGLFSLINVLADSVGPGTVGL----YGDSHFFFLTSAFTTLAFTLLHTFWGVVFFHAWDNRSYGKITFVCLSHLLVSCMTLLNQQ----RLYVASFIPLYIVTITSGVLAYQSAGGSWKSLLASLSTKNSN 246          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: EEB15054.1 (gamma-secretase subunit Aph-1, putative [Pediculus humanus corporis])

HSP 1 Score: 142.895 bits (359), Expect = 5.264e-41
Identity = 90/186 (48.39%), Postives = 124/186 (66.67%), Query Frame = 0

Query:   14 FGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGI 199
            FG P AMF+ TIA DP+RII+L+ S+FFWL+S L+SS   + ++P +H   +GL++SV FQE+FR ++Y L+  A   + K+T+N+    +  HILAYV G GFGI SGLF L+NVLADSLGP T+G+  G    S  FF+ SA  +L  +L HT WGVI FSA + K Y+ +  V   H  +S +
Sbjct:    7 FGPPLAMFVCTIALDPIRIIILIASAFFWLLSFLLSSFL-WFIIPGQHLS-YGLLYSVLFQELFRFIVYKLIRSAEGGLKKITDNETQIIENKHILAYVAGLGFGIMSGLFALINVLADSLGPATMGLHQG----SEKFFMTSAATTLCFILLHTFWGVIFFSAADSKNYINITWVLLTHLIVSAL 186          

BLAST of EMLSAG00000000913 vs. Select Arthropod Genomes
Match: gb|EEC01233.1| (anterior pharynx defective, putative [Ixodes scapularis])

HSP 1 Score: 142.51 bits (358), Expect = 1.414e-40
Identity = 96/204 (47.06%), Postives = 130/204 (63.73%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTE---NDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVI 201
            MT   F+G  L AFG   +MF  T+A DP+RII+L+ ++FFWL++ L+SS+ WFA VPLR E  FG+VFSV FQE FR L Y +L KA   + K+TE   +          L+YV G GFGI SG+F L+NVLAD+ GPGT+G+ GG    S +FF+ SAL + A VL HT WGV++F A +  ++  +  V A H   S + +
Sbjct:    1 MTLMEFFGCTLIAFGPALSMFAITVARDPIRIIILITAAFFWLLALLLSSILWFAAVPLRKELAFGVVFSVFFQEAFRYLFYKILRKAEVGLKKVTEVGADGASVSTSRTTLSYVAGLGFGIMSGVFSLLNVLADATGPGTVGLHGG----SPYFFVTSALTTQAFVLLHTFWGVVSFHALDHGRWPLVGFVLACHLTASTLTL 200          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|290563082|gb|ADD38935.1| (Gamma-secretase subunit Aph-1 [Lepeophtheirus salmonis])

HSP 1 Score: 437.958 bits (1125), Expect = 4.004e-154
Identity = 228/261 (87.36%), Postives = 236/261 (90.42%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSK----PITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGDSSTNVFVR 257
            MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLIS LISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGI + ++     +T + TY    +L S++      F    GSVNSLKACFALRNGDSSTNVFVR
Sbjct:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISLLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGISLLNQSQLYALTLITTYL---ILTSSIAMA---FFIAGGSVNSLKACFALRNGDSSTNVFVR 255          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|290462079|gb|ADD24087.1| (Gamma-secretase subunit Aph-1 [Lepeophtheirus salmonis])

HSP 1 Score: 435.647 bits (1119), Expect = 2.945e-153
Identity = 227/261 (86.97%), Postives = 235/261 (90.04%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSK----PITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGDSSTNVFVR 257
            MTAWTFWGT LTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLIS LISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGI + ++     +T + TY    +L S++      F    GSVNSLKACFALRNGDSSTNVFVR
Sbjct:    1 MTAWTFWGTLLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISLLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGISLLNQSQLYALTLITTYL---ILTSSIAMA---FFIAGGSVNSLKACFALRNGDSSTNVFVR 255          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|225711918|gb|ACO11805.1| (Gamma-secretase subunit Aph-1 [Lepeophtheirus salmonis])

HSP 1 Score: 434.106 bits (1115), Expect = 1.412e-152
Identity = 226/261 (86.59%), Postives = 234/261 (89.66%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSK----PITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGDSSTNVFVR 257
            MTAWTFWGT LTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLIS LISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSL IVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGI + ++     +T + TY    +L S++      F    GSVNSLKACFALRNGDSSTNVFVR
Sbjct:    1 MTAWTFWGTLLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISLLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLVIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGISLLNQSQLYALTLITTYL---ILTSSIAMA---FFIAGGSVNSLKACFALRNGDSSTNVFVR 255          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|665819102|ref|XP_008558412.1| (PREDICTED: gamma-secretase subunit Aph-1 [Microplitis demolitor])

HSP 1 Score: 187.578 bits (475), Expect = 1.273e-55
Identity = 113/249 (45.38%), Postives = 148/249 (59.44%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRNGD 249
            MTA  F+G  L AFG P AMF  T++ +P+RII+L+ S+FFWLIS L SS+ W+AVVPL++   FGLVFSV FQE FR LLY +L KA   + K+T       +  HI AYV G GFG  SG F LVNVLAD++GPGT+G+K G    S +FFI SA  +L  +L HT WGVI FSA ++KK+  +  V   H   S + + ++      TY    V    +I     F    G + ++  CF L   D
Sbjct:    1 MTASDFFGCALLAFGPPLAMFTITVSSEPIRIIILIASAFFWLISLLFSSILWYAVVPLQNNLAFGLVFSVLFQEAFRYLLYWVLRKAEKGLEKVTTAH--LANSRHIFAYVCGLGFGFMSGAFALVNVLADAVGPGTMGLKQG----SEYFFIMSAATTLCFILLHTFWGVIFFSAADDKKWGHIAWVVLSHLFASCMTLINR--YEAYTYSLLSVYTVLIITMGLAFKVAGGKIQNIPKCFTLIKRD 241          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|914574049|gb|KOB76437.1| (Anterior pharynx defective 1 [Operophtera brumata])

HSP 1 Score: 180.259 bits (456), Expect = 9.065e-53
Identity = 107/247 (43.32%), Postives = 149/247 (60.32%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRN 247
            MT   F+   L AFGAP AMF  TIA DPVRII++++++F WL++ L+SSL WFAVVPLR    FG+VF++ FQE FR  +YLLL K  + M +++EN  I  ++   +AYV G GFGI SG F L+NVLADS GPGTLG+K G    S  FF+ SA  +L ++L +T W VI +S  +EK  L++  V   H+ +S + + ++    + T     V+   VI     F    G+  S    F  R+
Sbjct:    1 MTLAEFFSCSLLAFGAPLAMFTMTIAHDPVRIIIMIVAAFGWLLAFLLSSLVWFAVVPLRSYLAFGMVFAIIFQEAFRYGMYLLLRKTEAGMKEISENHDIGSNRTE-MAYVSGLGFGIMSGAFALINVLADSAGPGTLGLKSG----SEFFFVTSAAMTLCMILLNTFWSVIFYSGIDEKNKLKIAWVIISHFVVSSLSLLNRKEIYMSTILPSYVI--LVITMLLAFRSAGGTAKSFIQSFTPRD 240          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|913312794|ref|XP_013187142.1| (PREDICTED: gamma-secretase subunit Aph-1b [Amyelois transitella])

HSP 1 Score: 178.718 bits (452), Expect = 3.279e-52
Identity = 95/205 (46.34%), Postives = 136/205 (66.34%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKP 205
            MT   F+   L A+GAP  MF  T+A DPVRII+++ ++F WL+S L+SS+ W+AVVPLR    FG+ F++ FQE+FR  +Y LL K  + + +++EN  I  +K   +AYV G GFG  SG F LVNVLADS+GPGTLG++ G    S +FF+ SA  +L ++L +T W VI FS C+EK Y ++  V   H+ +SGI + ++ 
Sbjct:    1 MTLAEFFSCSLLAYGAPFVMFSITVANDPVRIIIMIAAAFGWLLSFLLSSVVWYAVVPLRSYLAFGMTFAIIFQELFRYGMYRLLKKTEAGLKEISENHDIGANKLE-MAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLQSG----SEYFFVTSAAMTLCMILLNTFWSVIFFSGCDEKNYFKVSWVLVSHFFVSGISLLNRK 200          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|1000743321|ref|XP_015594338.1| (PREDICTED: gamma-secretase subunit Aph-1 [Cephus cinctus])

HSP 1 Score: 177.563 bits (449), Expect = 8.854e-52
Identity = 97/183 (53.01%), Postives = 122/183 (66.67%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKY 183
            MT   F+G    AFG P AMF FT+A +P+RII+L+ S+FFWLIS LISS  W+AVVPL+    FGLVFSV FQE FR LLY +L KA   + ++T       D  H+ AYV G GFG  SG F LVNVLAD++GPGT+G++ G    S +FFI SA  +L  +  HT WG+I FSA + KK+
Sbjct:    1 MTVMDFFGCAFLAFGPPLAMFTFTVAVEPIRIIILIASAFFWLISLLISSALWYAVVPLQDHLAFGLVFSVLFQEAFRYLLYWVLRKAERGLERVTTAHV--ADSRHVFAYVCGLGFGFMSGAFALVNVLADAVGPGTMGLRQG----SEYFFIISAATTLCFIFLHTFWGIIFFSAFDHKKW 177          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|676454988|ref|XP_009053860.1| (hypothetical protein LOTGIDRAFT_116865 [Lottia gigantea] >gi|556106698|gb|ESO95350.1| hypothetical protein LOTGIDRAFT_116865 [Lottia gigantea])

HSP 1 Score: 177.948 bits (450), Expect = 1.003e-51
Identity = 108/206 (52.43%), Postives = 135/206 (65.53%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKP------HILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIV 200
            MT   F+G    AFG P AMFIFTIA DP+RII+L+ S FFWL+S L+SS+ W+AVVPLR    FGLVFSV FQE+FR L Y LL KA   + K+++N P     P      HI+AYV G G+GI SG F +VNVLAD  GPGT+GIKG     S  FF+ SA  +L  +L HT WGVI F+A + K+Y+ +  V A H  +S +V
Sbjct:    1 MTLMEFFGCAFIAFGPPFAMFIFTIARDPLRIIVLIASGFFWLLSLLLSSILWYAVVPLRTSLAFGLVFSVIFQELFRFLFYKLLRKADEGLKKVSQNVPDEHITPKDINNKHIMAYVSGLGYGILSGAFSIVNVLADMAGPGTIGIKGD----SHFFFLTSAFLTLCFILLHTFWGVIFFNALDRKRYIFVAGVVASHMLVSCLV 202          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|908506649|ref|XP_013064234.1| (PREDICTED: gamma-secretase subunit Aph-1-like [Biomphalaria glabrata] >gi|908506652|ref|XP_013064235.1| PREDICTED: gamma-secretase subunit Aph-1-like [Biomphalaria glabrata])

HSP 1 Score: 178.333 bits (451), Expect = 1.064e-51
Identity = 108/257 (42.02%), Postives = 151/257 (58.75%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKP------HILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIVITSKPITTLRT--YFDHDVLNSNVIDCHGI--FHRRXGSVNSLKACFALRN 247
            MT   F+G    AFG P A+FIFTIA DP+R+I+L+ SSFFWLI+ LISS+ WFAVVPLR    FGLVFSV FQE+FR L Y ++  A   + K+++        P      HI+AYV G GFG+ SG F L+NVLAD  GPG++GI G     S++FF  S+  +L  +L HT WGVI F+  + K Y  +  V A H  +S + + ++  ++  +  Y    +    ++   GI  F+   GS+ ++K C   R 
Sbjct:    1 MTLMEFFGCTFIAFGPPIALFIFTIAKDPMRVIVLIASSFFWLIALLISSILWFAVVPLRETLAFGLVFSVLFQELFRFLFYKIMRLANEGLIKVSQQSDNSNITPRDFANTHIMAYVSGLGFGLMSGAFSLINVLADLWGPGSIGIHGD----SKYFFWSSSYLTLCFILLHTMWGVIFFAGMDRKCYFYVAYVVATHMLVSCLTLLNQLSSSTDSAIYLGPLIPAYIILVVSGIFAFYTAGGSLANIKNCVTCRK 253          

BLAST of EMLSAG00000000913 vs. nr
Match: gi|170029264|ref|XP_001842513.1| (gamma-secretase subunit Aph-1 [Culex quinquefasciatus] >gi|167881616|gb|EDS44999.1| gamma-secretase subunit Aph-1 [Culex quinquefasciatus])

HSP 1 Score: 176.407 bits (446), Expect = 3.306e-51
Identity = 101/193 (52.33%), Postives = 124/193 (64.25%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTENDPIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMH 193
            MT   F+G    AFG P AMF  TIA DP+RII+L+ +SFFWL+S L+SS  WFAV PLR + VFGL+ SV  QE FR L+Y LL K    + ++TE   I  D  HIL+YV G GFGI SG F LVN+LADS+GP T+G+K G    S  F + SA  SL ++L HT W VI FSAC+ K Y  +  V   H
Sbjct:    1 MTVVEFFGCSFLAFGPPVAMFALTIAHDPIRIIILIAASFFWLVSLLLSSTVWFAVFPLRDKLVFGLICSVFIQEGFRYLMYKLLRKTERGLQEVTEIARI-SDYKHILSYVSGLGFGIISGAFSLVNILADSVGPATVGLKAG----SSVFILISAAQSLCMILLHTFWSVIFFSACDVKNYYHIGYVVTSH 188          

BLAST of EMLSAG00000000913 vs. Tigriopus kingsejongenis genes
Match: maker-scaffold934_size79169-snap-gene-0.22 (protein:Tk02399 transcript:maker-scaffold934_size79169-snap-gene-0.22-mRNA-1 annotation:"gamma-secretase subunit aph-1")

HSP 1 Score: 194.512 bits (493), Expect = 3.865e-62
Identity = 127/252 (50.40%), Postives = 170/252 (67.46%), Query Frame = 0

Query:    1 MTAWTFWGTFLTAFGAPSAMFIFTIAPDPVRIILLVLSSFFWLISXLISSLWWFAVVPLRHEPVFGLVFSVAFQEIFRILLYLLLFKARSFMSKLTEND--PIFGDKPHILAYVLGFGFGISSGLFGLVNVLADSLGPGTLGIKGGDFGVSRHFFIFSALFSLAIVLCHTAWGVIAFSACEEKKYLRLVTVWAMHYALSGIV---ITSKPITTLRTYFDHDVLNSNVIDCHGIFHRRXGSVNSLKACFALRN 247
            MTA TF+G  LTAFG   ++FIFTIA DPVRII+L+LS+FFWL+S L+SS  W  V PLR    FGL FSV FQE+FR+LLYLLL KA   M KLTEN+   IF +K HILAYV+G GFG+ +G+F LVN+LADSLGPGT+G KG     S+ FF+ SA  SLA++LCHT WGVI F+A ++ KY  +  VW  H+  SG+    ++   + ++   + + ++++ V      FH   GS+  L  CF+ ++
Sbjct:    1 MTALTFFGVALTAFGPALSLFIFTIARDPVRIIILILSAFFWLVSLLLSSGLWNVVYPLRDVLAFGLFFSVFFQEMFRLLLYLLLRKADRVMRKLTENEHTQIFENK-HILAYVVGLGFGMMAGVFSLVNILADSLGPGTVGWKGE----SQSFFMVSASLSLALILCHTCWGVITFAALDDGKYFWVALVWISHFLFSGLTLFNVSGLYVASVIPAYINLLISATV-----AFHCAGGSIPRLLKCFSCQS 242