BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:Krn "Keren" species:7227 "Drosophila melanogaster" [GO:0005886 "plasma membrane" evidence=ISS] [GO:0005154 "epidermal growth factor receptor binding" evidence=ISS] [GO:0007173 "epidermal growth factor receptor signaling pathway" evidence=NAS] [GO:0008083 "growth factor activity" evidence=ISS] [GO:0045741 "positive regulation of epidermal growth factor-activated receptor activity" evidence=IGI;IMP] [GO:0000165 "MAPK cascade" evidence=IDA] [GO:0016318 "ommatidial rotation" evidence=IMP] [GO:0005783 "endoplasmic reticulum" evidence=IDA] [GO:0007298 "border follicle cell migration" evidence=IMP] [GO:0042058 "regulation of epidermal growth factor receptor signaling pathway" evidence=IGI] [GO:0048749 "compound eye development" evidence=IGI] [GO:0008284 "positive regulation of cell proliferation" evidence=IMP] [GO:0008355 "olfactory learning" evidence=IMP] InterPro:IPR000742 Pfam:PF00008 PROSITE:PS50026 SMART:SM00181 GO:GO:0005783 GO:GO:0000165 GO:GO:0008355 EMBL:AE014296 GO:GO:0008284 GO:GO:0045741 InterPro:IPR013032 PROSITE:PS00022 GO:GO:0007298 PROSITE:PS01186 GO:GO:0016318 GeneTree:ENSGT00520000062215 OrthoDB:EOG7PZS0C UniGene:Dm.7750 EMBL:AF245387 EMBL:AY060409 RefSeq:NP_524129.1 SMR:Q9VVJ6 MINT:MINT-844062 STRING:7227.FBpp0074961 EnsemblMetazoa:FBtr0075197 GeneID:326198 KEGG:dme:Dmel_CG32179 UCSC:CG32179-RA CTD:326198 FlyBase:FBgn0052179 eggNOG:NOG122522 InParanoid:Q9VVJ6 KO:K16691 OMA:PRCEYKE GenomeRNAi:326198 NextBio:847586 PMAP-CutDB:Q9VVJ6 Uniprot:Q9VVJ6)

HSP 1 Score: 110.923 bits (276), Expect = 8.528e-28
Identity = 51/108 (47.22%), Postives = 66/108 (61.11%), Query Frame = 0

Query:   68 IXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSK 175
            I +  RP++T   +ACPP Y AWYCLN  TCF VKI   ILYNCECA G+MG RCE+K+ DGSYLP R ++ L K+    ++      L+ +A     LY +H    K
Sbjct:   47 ISTTPRPNVTFPIFACPPTYVAWYCLNDGTCFTVKIHNEILYNCECALGFMGPRCEYKEIDGSYLPTRNRVMLEKA---SIVSGATLALLFMAMCCVVLYLRHEKLQK 151          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:spi "spitz" species:7227 "Drosophila melanogaster" [GO:0005576 "extracellular region" evidence=NAS;TAS] [GO:0005154 "epidermal growth factor receptor binding" evidence=NAS;TAS] [GO:0007173 "epidermal growth factor receptor signaling pathway" evidence=NAS;TAS] [GO:0061331 "epithelial cell proliferation involved in Malpighian tubule morphogenesis" evidence=IMP] [GO:0045742 "positive regulation of epidermal growth factor receptor signaling pathway" evidence=NAS] [GO:0008317 "gurken receptor binding" evidence=NAS] [GO:0005886 "plasma membrane" evidence=NAS] [GO:0046845 "branched duct epithelial cell fate determination, open tracheal system" evidence=TAS] [GO:0007421 "stomatogastric nervous system development" evidence=IMP] [GO:0007432 "salivary gland boundary specification" evidence=NAS] [GO:0005794 "Golgi apparatus" evidence=IGI] [GO:0005783 "endoplasmic reticulum" evidence=NAS;IDA] [GO:0000086 "G2/M transition of mitotic cell cycle" evidence=NAS] [GO:0016330 "second mitotic wave involved in compound eye morphogenesis" evidence=NAS] [GO:0045470 "R8 cell-mediated photoreceptor organization" evidence=NAS] [GO:0016021 "integral component of membrane" evidence=NAS] [GO:0007438 "oenocyte development" evidence=IGI;IMP] [GO:0043066 "negative regulation of apoptotic process" evidence=IMP;NAS] [GO:0046673 "negative regulation of compound eye retinal cell programmed cell death" evidence=NAS] [GO:0007422 "peripheral nervous system development" evidence=IMP] [GO:0007424 "open tracheal system development" evidence=TAS] [GO:0035225 "determination of genital disc primordium" evidence=IMP] [GO:0035277 "spiracle morphogenesis, open tracheal system" evidence=IMP] [GO:0007298 "border follicle cell migration" evidence=IMP] [GO:0007476 "imaginal disc-derived wing morphogenesis" evidence=IMP] [GO:0008284 "positive regulation of cell proliferation" evidence=IMP] [GO:0048149 "behavioral response to ethanol" evidence=IMP] [GO:0048865 "stem cell fate commitment" evidence=IMP] [GO:0003015 "heart process" evidence=IMP] [GO:0022008 "neurogenesis" evidence=IMP] [GO:0008355 "olfactory learning" evidence=IMP] [GO:0050769 "positive regulation of neurogenesis" evidence=IMP] InterPro:IPR000742 Pfam:PF00008 PROSITE:PS50026 SMART:SM00181 GO:GO:0005783 GO:GO:0016021 GO:GO:0005886 GO:GO:0005794 GO:GO:0007173 GO:GO:0000086 GO:GO:0043066 GO:GO:0005576 GO:GO:0008355 GO:GO:0000139 EMBL:AE014134 GO:GO:0005789 GO:GO:0003015 GO:GO:0008284 GO:GO:0061331 GO:GO:0007422 InterPro:IPR013032 PROSITE:PS00022 GO:GO:0035225 GO:GO:0007438 GO:GO:0035277 GO:GO:0007298 GO:GO:0050769 GO:GO:0048149 GO:GO:0005154 PROSITE:PS01186 GO:GO:0045742 GO:GO:0007476 GO:GO:0016330 GO:GO:0045470 GO:GO:0007432 GO:GO:0046845 PDB:3LTF PDB:3LTG PDBsum:3LTF PDBsum:3LTG GO:GO:0046673 GO:GO:0048865 GO:GO:0007421 PDB:3C9A PDBsum:3C9A eggNOG:NOG329056 EMBL:M95199 EMBL:AY089693 PIR:A44074 RefSeq:NP_001027281.1 RefSeq:NP_476909.2 RefSeq:NP_599118.2 RefSeq:NP_599119.2 RefSeq:NP_599120.2 UniGene:Dm.4573 PDB:3CA7 PDBsum:3CA7 ProteinModelPortal:Q01083 SMR:Q01083 BioGrid:61229 DIP:DIP-18037N IntAct:Q01083 MINT:MINT-785907 EnsemblMetazoa:FBtr0081267 EnsemblMetazoa:FBtr0081268 EnsemblMetazoa:FBtr0081269 EnsemblMetazoa:FBtr0081270 EnsemblMetazoa:FBtr0100597 GeneID:35253 KEGG:dme:Dmel_CG10334 UCSC:CG10334-RA CTD:35253 FlyBase:FBgn0005672 GeneTree:ENSGT00520000062215 InParanoid:Q01083 OMA:LEHALMS OrthoDB:EOG7PZS0C PhylomeDB:Q01083 SignaLink:Q01083 ChiTaRS:spi EvolutionaryTrace:Q01083 GenomeRNAi:35253 NextBio:792614 PMAP-CutDB:Q01083 Bgee:Q01083 Uniprot:Q01083)

HSP 1 Score: 93.5893 bits (231), Expect = 2.357e-21
Identity = 50/111 (45.05%), Postives = 67/111 (60.36%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLK-SPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVE 184
            +IT  TY CP  + AWYCLN A CFAVKIA+  +Y+CECA G+MGQRCE+K+ D +YLP R +  L K S   G +    F L +  A    L  + R   K  +L +E++
Sbjct:   74 NITFPTYKCPETFDAWYCLNDAHCFAVKIADLPVYSCECAIGFMGQRCEYKEIDNTYLPKRPRPMLEKASIASGAMCALVFMLFVCLAFY--LRFEQRAAKKAYELEQELQ 182          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:grk "gurken" species:7227 "Drosophila melanogaster" [GO:0008070 "maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded" evidence=IMP] [GO:0030381 "chorion-containing eggshell pattern formation" evidence=IMP] [GO:0007314 "oocyte anterior/posterior axis specification" evidence=NAS;TAS] [GO:0005154 "epidermal growth factor receptor binding" evidence=NAS;TAS] [GO:0007310 "oocyte dorsal/ventral axis specification" evidence=NAS;TAS] [GO:0009952 "anterior/posterior pattern specification" evidence=TAS] [GO:0007309 "oocyte axis specification" evidence=NAS;TAS] [GO:0008069 "dorsal/ventral axis specification, ovarian follicular epithelium" evidence=NAS;TAS] [GO:0001709 "cell fate determination" evidence=TAS] [GO:0008314 "gurken signaling pathway" evidence=NAS;TAS] [GO:0008317 "gurken receptor binding" evidence=NAS] [GO:0046843 "dorsal appendage formation" evidence=NAS] [GO:0007298 "border follicle cell migration" evidence=IGI;IMP;TAS] [GO:0007173 "epidermal growth factor receptor signaling pathway" evidence=NAS] [GO:0030714 "anterior/posterior axis specification, follicular epithelium" evidence=NAS;TAS] [GO:0005783 "endoplasmic reticulum" evidence=TAS] [GO:0005576 "extracellular region" evidence=NAS] [GO:0000578 "embryonic axis specification" evidence=TAS] [GO:0001708 "cell fate specification" evidence=TAS] [GO:0030722 "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification" evidence=IMP] [GO:0016325 "oocyte microtubule cytoskeleton organization" evidence=IMP] InterPro:IPR000742 PROSITE:PS50026 SMART:SM00181 GO:GO:0005783 GO:GO:0016021 GO:GO:0005886 GO:GO:0001708 GO:GO:0005576 GO:GO:0000139 EMBL:AE014134 InterPro:IPR013032 PROSITE:PS00022 GO:GO:0007298 GO:GO:0005154 GO:GO:0046843 GO:GO:0001709 GO:GO:0007314 GO:GO:0016325 GO:GO:0030722 GO:GO:0008314 GO:GO:0030714 GO:GO:0030381 EMBL:L22531 EMBL:AF223394 EMBL:AY051814 PIR:A48844 RefSeq:NP_476568.2 UniGene:Dm.355 ProteinModelPortal:P42287 SMR:P42287 BioGrid:60293 DIP:DIP-20922N IntAct:P42287 MINT:MINT-320623 STRING:7227.FBpp0079313 EnsemblMetazoa:FBtr0079708 GeneID:34171 KEGG:dme:Dmel_CG17610 UCSC:CG17610-RA CTD:34171 FlyBase:FBgn0001137 eggNOG:NOG329056 InParanoid:P42287 KO:K02447 OMA:QQLHLHK OrthoDB:EOG7S4X7H PhylomeDB:P42287 SignaLink:P42287 GenomeRNAi:34171 NextBio:787225 PMAP-CutDB:P42287 Bgee:P42287 GO:GO:0090110 GO:GO:0008070 Uniprot:P42287)

HSP 1 Score: 48.9062 bits (115), Expect = 1.312e-5
Identity = 28/111 (25.23%), Postives = 51/111 (45.95%), Query Frame = 0

Query:   79 QTYACPPAYAAWYCLNGATCFAV-KIAESILYNCECADGYMGQRCEFKDPDGSYL---PARKKLYLLKSPGFG---LIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKE 182
            Q   C  AY   +CLNG  CF    +  ++ ++C C + Y G+RC +K  +G Y+   P  ++   +    F    L+ L++  ++  A  +      +R K +   L K+
Sbjct:  179 QMLPCSEAYNTSFCLNGGHCFQHPMVNNTVFHSCLCVNDYDGERCAYKSWNGDYIYSPPTAQRKVRMAHIVFSFPVLLMLSSLYVLFAAVFMLRNVPDYRRKQQQLHLHKQ 289          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:NRG3 "Pro-neuregulin-3, membrane-bound isoform" species:9606 "Homo sapiens" [GO:0001558 "regulation of cell growth" evidence=NAS] [GO:0005576 "extracellular region" evidence=NAS] [GO:0005887 "integral component of plasma membrane" evidence=NAS] [GO:0007171 "activation of transmembrane receptor protein tyrosine kinase activity" evidence=NAS] [GO:0007389 "pattern specification process" evidence=IEA] [GO:0008083 "growth factor activity" evidence=NAS] [GO:0030297 "transmembrane receptor protein tyrosine kinase activator activity" evidence=NAS] [GO:0030971 "receptor tyrosine kinase binding" evidence=NAS] [GO:0060596 "mammary placode formation" evidence=IEA] InterPro:IPR000742 PROSITE:PS50026 SMART:SM00181 Reactome:REACT_111102 Reactome:REACT_116125 Reactome:REACT_6900 GO:GO:0005576 GO:GO:0005887 GO:GO:0001558 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 GO:GO:0030297 GO:GO:0007389 GO:GO:0008083 GO:GO:0030971 GO:GO:0060596 EMBL:DQ857894 EMBL:DQ001411 EMBL:AL354749 EMBL:AL096706 EMBL:AL136085 EMBL:AL391478 EMBL:AL513204 EMBL:AL589782 RefSeq:NP_001010848.2 RefSeq:NP_001159445.1 RefSeq:XP_005269501.1 UniGene:Hs.125119 ProteinModelPortal:P56975 SMR:P56975 STRING:9606.ENSP00000361214 PhosphoSite:P56975 DMDM:9789758 PaxDb:P56975 PRIDE:P56975 Ensembl:ENST00000372141 Ensembl:ENST00000372142 Ensembl:ENST00000404547 GeneID:10718 KEGG:hsa:10718 UCSC:uc001kco.2 UCSC:uc001kcp.2 UCSC:uc001kcr.2 CTD:10718 GeneCards:GC10P083625 HGNC:HGNC:7999 HPA:HPA038206 MIM:605533 neXtProt:NX_P56975 PharmGKB:PA31778 eggNOG:NOG40523 HOGENOM:HOG000113852 HOVERGEN:HBG006532 InParanoid:P56975 KO:K05457 OrthoDB:EOG7SR4KZ PhylomeDB:P56975 TreeFam:TF336537 SignaLink:P56975 GeneWiki:NRG3 GenomeRNAi:10718 NextBio:40693 PRO:PR:P56975 ArrayExpress:P56975 Bgee:P56975 CleanEx:HS_NRG3 Genevestigator:P56975 Uniprot:P56975)

HSP 1 Score: 46.9802 bits (110), Expect = 8.114e-5
Identity = 27/110 (24.55%), Postives = 49/110 (44.55%), Query Frame = 0

Query:   91 YCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTA---------------FGLVILAAILGALYTKHRTKSKLTQLRKEVEV 185
            YCLN   CF ++       +C C +GY G RC+       +LP    +    +   G+ F+ +               FG+VI+     A Y K + ++K  Q++++++V
Sbjct:  297 YCLNDGECFVIETLTGSHKHCRCKEGYQGVRCD------QFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAK--QIQEQLKV 398          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:LOC100859166 "Uncharacterized protein" species:9031 "Gallus gallus" [GO:0005102 "receptor binding" evidence=IEA] [GO:0007389 "pattern specification process" evidence=IEA] [GO:0009790 "embryo development" evidence=IEA] [GO:0060596 "mammary placode formation" evidence=IEA] InterPro:IPR000742 InterPro:IPR002154 Pfam:PF02158 PROSITE:PS50026 SMART:SM00181 InterPro:IPR013032 PROSITE:PS00022 GO:GO:0009790 PROSITE:PS01186 GeneTree:ENSGT00710000106660 CTD:10718 KO:K05457 OrthoDB:EOG7SR4KZ TreeFam:TF336537 EMBL:AADN03004997 EMBL:AADN03005062 EMBL:AADN03005167 RefSeq:XP_426491.4 Ensembl:ENSGALT00000003717 GeneID:428937 KEGG:gga:428937 Uniprot:F1NZ88)

HSP 1 Score: 46.9802 bits (110), Expect = 8.150e-5
Identity = 28/108 (25.93%), Postives = 46/108 (42.59%), Query Frame = 0

Query:   91 YCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTA---------------FGLVILAAILGALY--TKHRTKSKLTQLRK 181
            YCLN   CF ++       +C C +GY G RC+       +LP    +    +   G+ F+ +               FG+V++  +  A Y  TK +TK    QL++
Sbjct:   74 YCLNEGECFVIETLTGSHKHCRCKEGYQGVRCD------QFLPKTDSILSDPTDHLGIEFMESEEIYQRQVLSISCIVFGIVVVGMLCAAFYFKTKKQTKQIHEQLKE 175          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:NRG3 "Pro-neuregulin-3, membrane-bound isoform" species:9606 "Homo sapiens" [GO:0005102 "receptor binding" evidence=IEA] [GO:0009790 "embryo development" evidence=IEA] InterPro:IPR000742 InterPro:IPR002154 Pfam:PF02158 PROSITE:PS50026 SMART:SM00181 InterPro:IPR013032 PROSITE:PS00022 GO:GO:0009790 PROSITE:PS01186 EMBL:AL354749 EMBL:AL096706 EMBL:AL136085 EMBL:AL391478 EMBL:AL513204 EMBL:AL589782 UniGene:Hs.125119 GeneID:10718 KEGG:hsa:10718 CTD:10718 HGNC:HGNC:7999 KO:K05457 EMBL:AC010157 EMBL:AL096705 EMBL:AL096863 EMBL:AL096864 EMBL:AL356129 EMBL:AL358552 EMBL:AL513316 EMBL:HM068883 RefSeq:XP_005269504.1 ProteinModelPortal:D9ZHQ6 SMR:D9ZHQ6 Ensembl:ENST00000404576 UCSC:uc021pve.1 NextBio:35496030 ArrayExpress:D9ZHQ6 Uniprot:D9ZHQ6)

HSP 1 Score: 46.595 bits (109), Expect = 1.064e-4
Identity = 27/110 (24.55%), Postives = 49/110 (44.55%), Query Frame = 0

Query:   91 YCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTA---------------FGLVILAAILGALYTKHRTKSKLTQLRKEVEV 185
            YCLN   CF ++       +C C +GY G RC+       +LP    +    +   G+ F+ +               FG+VI+     A Y K + ++K  Q++++++V
Sbjct:  101 YCLNDGECFVIETLTGSHKHCRCKEGYQGVRCD------QFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAK--QIQEQLKV 202          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:NRG3 "Pro-neuregulin-3, membrane-bound isoform" species:9606 "Homo sapiens" [GO:0005102 "receptor binding" evidence=IEA] [GO:0009790 "embryo development" evidence=IEA] InterPro:IPR000742 InterPro:IPR002154 Pfam:PF02158 PROSITE:PS50026 SMART:SM00181 InterPro:IPR013032 PROSITE:PS00022 GO:GO:0009790 PROSITE:PS01186 EMBL:AL354749 EMBL:AL096706 EMBL:AL136085 EMBL:AL391478 EMBL:AL513204 EMBL:AL589782 UniGene:Hs.125119 GeneID:10718 KEGG:hsa:10718 CTD:10718 HGNC:HGNC:7999 KO:K05457 EMBL:AC010157 EMBL:AL096705 EMBL:AL096863 EMBL:AL096864 EMBL:AL356129 EMBL:AL358552 EMBL:AL513316 EMBL:HM068884 RefSeq:XP_005269502.1 ProteinModelPortal:D9ZHQ7 SMR:D9ZHQ7 Ensembl:ENST00000556918 UCSC:uc021pvi.1 OMA:TIPCQGY NextBio:35496031 ArrayExpress:D9ZHQ7 Uniprot:D9ZHQ7)

HSP 1 Score: 46.595 bits (109), Expect = 1.082e-4
Identity = 27/110 (24.55%), Postives = 49/110 (44.55%), Query Frame = 0

Query:   91 YCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTA---------------FGLVILAAILGALYTKHRTKSKLTQLRKEVEV 185
            YCLN   CF ++       +C C +GY G RC+       +LP    +    +   G+ F+ +               FG+VI+     A Y K + ++K  Q++++++V
Sbjct:  127 YCLNDGECFVIETLTGSHKHCRCKEGYQGVRCD------QFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAK--QIQEQLKV 228          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:M0RAK7 "Uncharacterized protein" species:10116 "Rattus norvegicus" [GO:0005509 "calcium ion binding" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] InterPro:IPR000742 InterPro:IPR001881 InterPro:IPR018097 Pfam:PF07645 PROSITE:PS01187 PROSITE:PS50026 SMART:SM00179 SMART:SM00181 InterPro:IPR000033 InterPro:IPR000152 GO:GO:0016021 GO:GO:0005509 Gene3D:2.120.10.30 InterPro:IPR011042 SMART:SM00135 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS00010 InterPro:IPR009030 SUPFAM:SSF57184 Pfam:PF00058 PROSITE:PS51120 GeneTree:ENSGT00740000114992 Gene3D:2.40.155.10 InterPro:IPR023413 InterPro:IPR016317 PIRSF:PIRSF001778 OrthoDB:EOG7Q2N4J EMBL:AABR06013300 EMBL:AABR06013301 EMBL:AABR06013302 EMBL:AABR06013303 EMBL:AABR06013304 EMBL:AABR06013305 EMBL:AABR06013306 EMBL:AABR06013307 EMBL:AABR06013308 EMBL:AABR06013309 EMBL:AABR06013310 Ensembl:ENSRNOT00000073012 OMA:CHELITC Uniprot:M0RAK7)

HSP 1 Score: 46.595 bits (109), Expect = 1.194e-4
Identity = 23/55 (41.82%), Postives = 31/55 (56.36%), Query Frame = 0

Query:   72 IRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKD 126
            +R  IT     CPP+Y   YCLNG  C  V+  +   Y C C  GY+G+RC+ +D
Sbjct:  971 VRNSIT----GCPPSYDG-YCLNGGVCMYVESVDR--YVCNCVIGYIGERCQHRD 1018          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:EGF "Uncharacterized protein" species:9031 "Gallus gallus" [GO:0000186 "activation of MAPKK activity" evidence=IEA] [GO:0001525 "angiogenesis" evidence=IEA] [GO:0005154 "epidermal growth factor receptor binding" evidence=IEA] [GO:0005509 "calcium ion binding" evidence=IEA] [GO:0005615 "extracellular space" evidence=IEA] [GO:0005765 "lysosomal membrane" evidence=IEA] [GO:0005886 "plasma membrane" evidence=IEA] [GO:0007173 "epidermal growth factor receptor signaling pathway" evidence=IEA] [GO:0007262 "STAT protein import into nucleus" evidence=IEA] [GO:0008083 "growth factor activity" evidence=IEA] [GO:0010800 "positive regulation of peptidyl-threonine phosphorylation" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0018108 "peptidyl-tyrosine phosphorylation" evidence=IEA] [GO:0021940 "positive regulation of cerebellar granule cell precursor proliferation" evidence=IEA] [GO:0035413 "positive regulation of catenin import into nucleus" evidence=IEA] [GO:0043388 "positive regulation of DNA binding" evidence=IEA] [GO:0043406 "positive regulation of MAP kinase activity" evidence=IEA] [GO:0045741 "positive regulation of epidermal growth factor-activated receptor activity" evidence=IEA] [GO:0045840 "positive regulation of mitosis" evidence=IEA] [GO:0045893 "positive regulation of transcription, DNA-templated" evidence=IEA] [GO:0048754 "branching morphogenesis of an epithelial tube" evidence=IEA] [GO:0051048 "negative regulation of secretion" evidence=IEA] [GO:0060749 "mammary gland alveolus development" evidence=IEA] [GO:0070371 "ERK1 and ERK2 cascade" evidence=IEA] [GO:0090279 "regulation of calcium ion import" evidence=IEA] [GO:0090370 "negative regulation of cholesterol efflux" evidence=IEA] [GO:1900127 "positive regulation of hyaluronan biosynthetic process" evidence=IEA] [GO:2000008 "regulation of protein localization to cell surface" evidence=IEA] [GO:2000060 "positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" evidence=IEA] InterPro:IPR000742 InterPro:IPR001881 InterPro:IPR018097 Pfam:PF00008 Pfam:PF07645 PROSITE:PS01187 PROSITE:PS50026 SMART:SM00179 SMART:SM00181 InterPro:IPR000033 InterPro:IPR000152 GO:GO:0016021 GO:GO:0005886 GO:GO:0000186 GO:GO:0007173 GO:GO:0045893 GO:GO:0005615 GO:GO:0005509 GO:GO:0043406 GO:GO:0070371 Gene3D:2.120.10.30 InterPro:IPR011042 SMART:SM00135 GO:GO:0018108 GO:GO:0045741 GO:GO:0010800 GO:GO:0001525 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 GO:GO:0045840 GO:GO:0060749 PROSITE:PS00010 GO:GO:2000060 GO:GO:0048754 GO:GO:0035413 InterPro:IPR009030 SUPFAM:SSF57184 GO:GO:0043388 GO:GO:2000008 GO:GO:0090279 Pfam:PF00058 PROSITE:PS51120 GeneTree:ENSGT00740000114992 GO:GO:0007262 InterPro:IPR016317 PIRSF:PIRSF001778 OMA:DHDPVEN OrthoDB:EOG7Q2N4J TreeFam:TF315253 GO:GO:0090370 GO:GO:0051048 GO:GO:0021940 GO:GO:1900127 EMBL:AADN03004075 ProteinModelPortal:F1NEP5 Ensembl:ENSGALT00000019851 PRO:PR:F1NEP5 Uniprot:F1NEP5)

HSP 1 Score: 46.595 bits (109), Expect = 1.242e-4
Identity = 23/56 (41.07%), Postives = 32/56 (57.14%), Query Frame = 0

Query:   71 AIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKD 126
            + RP +   +  CPPAY + YCL+G  C  V   +   Y C C  GY+G+RC+F D
Sbjct: 1020 STRP-VPGDSIGCPPAYDS-YCLHGGVCNYVSDLQD--YACNCVTGYVGERCQFSD 1071          

BLAST of EMLSAG00000012242 vs. GO
Match: - (symbol:Nrg3 "neuregulin 3" species:10090 "Mus musculus" [GO:0005515 "protein binding" evidence=IPI] [GO:0005576 "extracellular region" evidence=IEA] [GO:0005622 "intracellular" evidence=IDA] [GO:0005886 "plasma membrane" evidence=IEA] [GO:0007389 "pattern specification process" evidence=IMP] [GO:0008083 "growth factor activity" evidence=IEA] [GO:0016020 "membrane" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0030879 "mammary gland development" evidence=IMP;IDA] [GO:0035556 "intracellular signal transduction" evidence=IDA] [GO:0060596 "mammary placode formation" evidence=IMP] InterPro:IPR000742 PROSITE:PS50026 SMART:SM00181 MGI:MGI:1097165 GO:GO:0016021 GO:GO:0005886 GO:GO:0005576 GO:GO:0035556 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 GO:GO:0007389 GO:GO:0060596 GeneTree:ENSGT00710000106660 CTD:10718 eggNOG:NOG40523 HOVERGEN:HBG006532 KO:K05457 OrthoDB:EOG7SR4KZ TreeFam:TF336537 EMBL:AF010130 PIR:T44447 RefSeq:NP_032760.1 UniGene:Mm.258705 ProteinModelPortal:O35181 SMR:O35181 PhosphoSite:O35181 PRIDE:O35181 Ensembl:ENSMUST00000166968 GeneID:18183 KEGG:mmu:18183 UCSC:uc007tbz.2 InParanoid:O35181 OMA:ESSFTGP NextBio:293498 PRO:PR:O35181 ArrayExpress:O35181 Bgee:O35181 CleanEx:MM_NRG3 Genevestigator:O35181 Uniprot:O35181)

HSP 1 Score: 46.595 bits (109), Expect = 1.265e-4
Identity = 26/103 (25.24%), Postives = 42/103 (40.78%), Query Frame = 0

Query:   91 YCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTA---------------FGLVILAAILGALYTKHRTKSKLTQ 178
            YCLN   CF ++       +C C +GY G RC+       +LP    +    +   G+ F+ +               FG+VI+     A Y K + ++K  Q
Sbjct:  299 YCLNDGECFVIETLTGSHKHCRCKEGYQGVRCD------QFLPKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQ 395          

BLAST of EMLSAG00000012242 vs. C. finmarchicus
Match: gi|592760758|gb|GAXK01193655.1| (TSA: Calanus finmarchicus comp496153_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 94.7449 bits (234), Expect = 7.570e-21
Identity = 68/135 (50.37%), Postives = 93/135 (68.89%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTXXXXXXXXXXXXLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYL---LKSPG----FGLIFLTXXXXXXXXXXXXXXYTKHRTKSKL---TQLRKEV 183
            R TP    P    +RP+IT QTYACPPAYAAWYCLNGATCF VKI +SILYNCECADG+MGQRCEFKD DG+YL + ++L +   +++ G    FG+I +      +  AI   ++T+ R+++++    Q+R+E 
Sbjct:  591 RSTPKPRPP-SPTMRPNITFQTYACPPAYAAWYCLNGATCFTVKIGQSILYNCECADGFMGQRCEFKDLDGTYLSSSERLRMAASVRTAGSSVTFGVIVII-----VGTAIGAVVFTRKRSRARMRHIEQIRRET 977          

BLAST of EMLSAG00000012242 vs. C. finmarchicus
Match: gi|592765058|gb|GAXK01189510.1| (TSA: Calanus finmarchicus comp621825_c1_seq1 transcribed RNA sequence)

HSP 1 Score: 34.2686 bits (77), Expect = 4.081e-1
Identity = 17/35 (48.57%), Postives = 20/35 (57.14%), Query Frame = 0

Query:   94 NGATCFAVKI-----AESILYNCECADGYMGQRCE 123
            N ATC  + I     A S+ Y CEC DGY G+ CE
Sbjct: 6952 NNATCLDLSITDFDSANSLRYYCECEDGYQGEHCE 7056          

BLAST of EMLSAG00000012242 vs. C. finmarchicus
Match: gi|592954538|gb|GAXK01004015.1| (TSA: Calanus finmarchicus comp255653_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 33.8834 bits (76), Expect = 4.548e-1
Identity = 20/43 (46.51%), Postives = 23/43 (53.49%), Query Frame = 0

Query:   93 LNGATC-FAVKIAESILYNCECADGYMGQRCEFK-DPDGSYLP 133
            +NG TC F   I E     C CA GY G+RCE K    G+Y P
Sbjct: 1827 MNGGTCQFYSTIGEQT---CHCARGYHGRRCERKYVSTGNYGP 1946          

BLAST of EMLSAG00000012242 vs. C. finmarchicus
Match: gi|592750129|gb|GAXK01204284.1| (TSA: Calanus finmarchicus comp411974_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 33.8834 bits (76), Expect = 4.877e-1
Identity = 15/35 (42.86%), Postives = 22/35 (62.86%), Query Frame = 0

Query:   93 LNGATCFAVK-IAESILYNCECADGYMGQRCEFKD 126
            LNG +C   + I E +   C C++G+ GQRC+FK 
Sbjct: 1060 LNGGSCLYYQSIGELV---CRCSEGFTGQRCQFKK 1155          

BLAST of EMLSAG00000012242 vs. C. finmarchicus
Match: gi|592750128|gb|GAXK01204285.1| (TSA: Calanus finmarchicus comp411974_c0_seq2 transcribed RNA sequence)

HSP 1 Score: 33.8834 bits (76), Expect = 4.959e-1
Identity = 15/35 (42.86%), Postives = 22/35 (62.86%), Query Frame = 0

Query:   93 LNGATCFAVK-IAESILYNCECADGYMGQRCEFKD 126
            LNG +C   + I E +   C C++G+ GQRC+FK 
Sbjct: 1043 LNGGSCLYYQSIGELV---CRCSEGFTGQRCQFKK 1138          

BLAST of EMLSAG00000012242 vs. C. finmarchicus
Match: gi|592838810|gb|GAXK01118734.1| (TSA: Calanus finmarchicus comp1090267_c0_seq2 transcribed RNA sequence)

HSP 1 Score: 32.3426 bits (72), Expect = 1.327e+0
Identity = 16/38 (42.11%), Postives = 17/38 (44.74%), Query Frame = 0

Query:   93 LNGATC-FAVKIAESILYNCECADGYMGQRCEFKDPDG 129
            LNG  C  AV         C+C  GY G RCE K   G
Sbjct:  808 LNGGACSVAVVAPGEHQVVCQCVAGYAGARCELKHVQG 921          

BLAST of EMLSAG00000012242 vs. C. finmarchicus
Match: gi|592838811|gb|GAXK01118733.1| (TSA: Calanus finmarchicus comp1090267_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 32.3426 bits (72), Expect = 1.337e+0
Identity = 16/38 (42.11%), Postives = 17/38 (44.74%), Query Frame = 0

Query:   93 LNGATC-FAVKIAESILYNCECADGYMGQRCEFKDPDG 129
            LNG  C  AV         C+C  GY G RCE K   G
Sbjct:  875 LNGGACSVAVVAPGEHQVVCQCVAGYAGARCELKHVQG 988          

BLAST of EMLSAG00000012242 vs. L. salmonis peptides
Match: EMLSAP00000012242 (pep:novel supercontig:LSalAtl2s:LSalAtl2s891:23413:24135:1 gene:EMLSAG00000012242 transcript:EMLSAT00000012242 description:"augustus_masked-LSalAtl2s891-processed-gene-0.0")

HSP 1 Score: 405.986 bits (1042), Expect = 5.568e-144
Identity = 240/240 (100.00%), Postives = 240/240 (100.00%), Query Frame = 0

Query:    1 MFPGLGLNWRSLLLFLVGVLLRGSEACSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVEVISISSKCSTNIQRQSISFDISSRDRLEAGPKPSYYDEIARSSSCHFLFNSSIVKC 240
            MFPGLGLNWRSLLLFLVGVLLRGSEACSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVEVISISSKCSTNIQRQSISFDISSRDRLEAGPKPSYYDEIARSSSCHFLFNSSIVKC
Sbjct:    1 MFPGLGLNWRSLLLFLVGVLLRGSEACSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVEVISISSKCSTNIQRQSISFDISSRDRLEAGPKPSYYDEIARSSSCHFLFNSSIVKC 240          

BLAST of EMLSAG00000012242 vs. L. salmonis peptides
Match: EMLSAP00000000722 (pep:novel supercontig:LSalAtl2s:LSalAtl2s1113:94882:99208:1 gene:EMLSAG00000000722 transcript:EMLSAT00000000722 description:"maker-LSalAtl2s1113-augustus-gene-0.12")

HSP 1 Score: 92.0485 bits (227), Expect = 2.626e-23
Identity = 41/54 (75.93%), Postives = 46/54 (85.19%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCE 112
            R TP    P+ SA+RP+IT +TYACPPAYAAWYCLNGATCF +KIAESILYNCE
Sbjct:   59 RSTPKPRLPVHSAMRPNITFETYACPPAYAAWYCLNGATCFTLKIAESILYNCE 112          

BLAST of EMLSAG00000012242 vs. SwissProt
Match: gi|50403762|sp|Q01083.2|SPITZ_DROME (RecName: Full=Protein spitz; Flags: Precursor)

HSP 1 Score: 93.5893 bits (231), Expect = 5.472e-22
Identity = 50/111 (45.05%), Postives = 67/111 (60.36%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLK-SPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVE 184
            +IT  TY CP  + AWYCLN A CFAVKIA+  +Y+CECA G+MGQRCE+K+ D +YLP R +  L K S   G +    F L +  A    L  + R   K  +L +E++
Sbjct:   74 NITFPTYKCPETFDAWYCLNDAHCFAVKIADLPVYSCECAIGFMGQRCEYKEIDNTYLPKRPRPMLEKASIASGAMCALVFMLFVCLAFY--LRFEQRAAKKAYELEQELQ 182          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: gb|KFM74290.1| (Protein spitz, partial [Stegodyphus mimosarum])

HSP 1 Score: 138.272 bits (347), Expect = 7.020e-40
Identity = 69/128 (53.91%), Postives = 90/128 (70.31%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVEVI 186
            R TP    P  + +RP+IT QTYACP AYA WYCLNGATCFAVKI +SILYNCECADGYMGQRCEFKD DGSYLP+R+++ + ++   G + + A  LV L +++  ++T+ R + K      E  +I
Sbjct:   25 RSTPKP-RPTSATMRPNITFQTYACPEAYAKWYCLNGATCFAVKIRDSILYNCECADGYMGQRCEFKDLDGSYLPSRERVMIERASIAGGVTI-AVLLVALISLIFYIHTRRRWREKYIAYYPEEAMI 150          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: gb|EEC03208.1| (protein spitz, putative, partial [Ixodes scapularis])

HSP 1 Score: 134.806 bits (338), Expect = 5.847e-39
Identity = 66/111 (59.46%), Postives = 79/111 (71.17%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTK 169
            R TP   +P  S +RP+IT QTY CP AYA WYCLNGATCFA+KI ESILYNCECADGYMGQRCEFKD DG+YLP R+++ + K+   G + L    LV L  +   LY +
Sbjct:   53 RSTPKPRAP-QSTVRPNITFQTYTCPEAYAKWYCLNGATCFAIKIGESILYNCECADGYMGQRCEFKDLDGTYLPTRQRVLIEKAGLAGGVTLAVL-LVFLIVVFVYLYYR 161          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: EFX61975.1 (hypothetical protein DAPPUDRAFT_271340 [Daphnia pulex])

HSP 1 Score: 126.716 bits (317), Expect = 7.090e-35
Identity = 53/73 (72.60%), Postives = 64/73 (87.67%), Query Frame = 0

Query:   71 AIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKS 143
            A+RP+IT QTYACPPAYA +YCLNGATCF +KI ESILYNCEC +G+MGQRCE+KD DGSYLP R+K+ L ++
Sbjct:   42 AVRPNITFQTYACPPAYATYYCLNGATCFTIKIGESILYNCECTEGFMGQRCEYKDLDGSYLPLREKIMLERA 114          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: EEB19960.1 (conserved hypothetical protein [Pediculus humanus corporis])

HSP 1 Score: 125.176 bits (313), Expect = 5.559e-34
Identity = 57/101 (56.44%), Postives = 75/101 (74.26%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSK 175
            +IT  TY CPP YAAWYCLNGATCF +KI ES+LYNCECA+G+MGQRCEFKD DGSYLP+R+++ L  +   G   +  F LV++A +   L+ + ++K K
Sbjct:   79 NITFPTYTCPPTYAAWYCLNGATCFTIKIEESLLYNCECAEGFMGQRCEFKDLDGSYLPSRQRVLLETASIAGGATIAVF-LVVIACVTLYLHYQRKSKEK 178          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: gb|KFM66232.1| (Protein spitz, partial [Stegodyphus mimosarum])

HSP 1 Score: 115.546 bits (288), Expect = 1.445e-30
Identity = 49/66 (74.24%), Postives = 59/66 (89.39%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYL 140
            +IT QTYACP AYA WYCLNGATCF+VKI ESILYNCECA+G++GQRCEFKD DGSYL +R+++ +
Sbjct:   94 NITFQTYACPEAYAKWYCLNGATCFSVKIGESILYNCECANGFVGQRCEFKDLDGSYLASRQQVMI 159          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: gb|EFA01327.2| (keren [Tribolium castaneum])

HSP 1 Score: 114.775 bits (286), Expect = 3.634e-30
Identity = 48/66 (72.73%), Postives = 57/66 (86.36%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYL 140
            +IT  TY CPPAYAAWYCLNGATCF VKI +S+LYNCECA+GYMG RCE+KD DGSYLP++++  L
Sbjct:   94 NITFHTYECPPAYAAWYCLNGATCFTVKIGDSLLYNCECAEGYMGPRCEYKDLDGSYLPSQRRFML 159          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: AAF49315.1 (keren [Drosophila melanogaster])

HSP 1 Score: 110.923 bits (276), Expect = 4.553e-29
Identity = 51/108 (47.22%), Postives = 66/108 (61.11%), Query Frame = 0

Query:   68 IXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSK 175
            I +  RP++T   +ACPP Y AWYCLN  TCF VKI   ILYNCECA G+MG RCE+K+ DGSYLP R ++ L K+    ++      L+ +A     LY +H    K
Sbjct:   47 ISTTPRPNVTFPIFACPPTYVAWYCLNDGTCFTVKIHNEILYNCECALGFMGPRCEYKEIDGSYLPTRNRVMLEKA---SIVSGATLALLFMAMCCVVLYLRHEKLQK 151          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: XP_016772438.1 (PREDICTED: uncharacterized protein LOC100577697 isoform X2 [Apis mellifera])

HSP 1 Score: 112.849 bits (281), Expect = 2.254e-28
Identity = 52/100 (52.00%), Postives = 69/100 (69.00%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKS 174
            +IT   Y CPP YA +YCLNGATCF VKI +S+LYNC CA+GY+GQRCEFKD DGSYLP+R+++ L  +   G   +  F LV++  I   ++ K + K 
Sbjct:  216 NITFHMYTCPPDYAEYYCLNGATCFTVKIVDSLLYNCLCANGYIGQRCEFKDLDGSYLPSRQRVMLETASIAGGATIAVF-LVVIICIAAYIHCKRKQKE 314          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: XP_016772437.1 (PREDICTED: uncharacterized protein LOC100577697 isoform X1 [Apis mellifera])

HSP 1 Score: 112.849 bits (281), Expect = 6.869e-28
Identity = 52/99 (52.53%), Postives = 69/99 (69.70%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTK 173
            +IT   Y CPP YA +YCLNGATCF VKI +S+LYNC CA+GY+GQRCEFKD DGSYLP+R+++ L  +   G   +  F LV++  I   ++ K + K
Sbjct:  342 NITFHMYTCPPDYAEYYCLNGATCFTVKIVDSLLYNCLCANGYIGQRCEFKDLDGSYLPSRQRVMLETASIAGGATIAVF-LVVIICIAAYIHCKRKQK 439          

BLAST of EMLSAG00000012242 vs. Select Arthropod Genomes
Match: AAZ66477.1 (spitz, isoform G [Drosophila melanogaster])

HSP 1 Score: 93.5893 bits (231), Expect = 2.652e-22
Identity = 50/111 (45.05%), Postives = 67/111 (60.36%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLK-SPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVE 184
            +IT  TY CP  + AWYCLN A CFAVKIA+  +Y+CECA G+MGQRCE+K+ D +YLP R +  L K S   G +    F L +  A    L  + R   K  +L +E++
Sbjct:   74 NITFPTYKCPETFDAWYCLNDAHCFAVKIADLPVYSCECAIGFMGQRCEYKEIDNTYLPKRPRPMLEKASIASGAMCALVFMLFVCLAFY--LRFEQRAAKKAYELEQELQ 182          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|675381388|gb|KFM74290.1| (Protein spitz, partial [Stegodyphus mimosarum])

HSP 1 Score: 138.272 bits (347), Expect = 3.435e-37
Identity = 69/128 (53.91%), Postives = 90/128 (70.31%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVEVI 186
            R TP    P  + +RP+IT QTYACP AYA WYCLNGATCFAVKI +SILYNCECADGYMGQRCEFKD DGSYLP+R+++ + ++   G + + A  LV L +++  ++T+ R + K      E  +I
Sbjct:   25 RSTPKP-RPTSATMRPNITFQTYACPEAYAKWYCLNGATCFAVKIRDSILYNCECADGYMGQRCEFKDLDGSYLPSRERVMIERASIAGGVTI-AVLLVALISLIFYIHTRRRWREKYIAYYPEEAMI 150          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|241123900|ref|XP_002404020.1| (protein spitz, putative [Ixodes scapularis] >gi|215493567|gb|EEC03208.1| protein spitz, putative, partial [Ixodes scapularis])

HSP 1 Score: 134.806 bits (338), Expect = 2.861e-36
Identity = 66/111 (59.46%), Postives = 79/111 (71.17%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTK 169
            R TP   +P  S +RP+IT QTY CP AYA WYCLNGATCFA+KI ESILYNCECADGYMGQRCEFKD DG+YLP R+++ + K+   G + L    LV L  +   LY +
Sbjct:   53 RSTPKPRAP-QSTVRPNITFQTYTCPEAYAKWYCLNGATCFAIKIGESILYNCECADGYMGQRCEFKDLDGTYLPTRQRVLIEKAGLAGGVTLAVL-LVFLIVVFVYLYYR 161          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|1073696997|gb|JAT91555.1| (putative transforming growth factor alpha-like protein, partial [Amblyomma aureolatum])

HSP 1 Score: 134.806 bits (338), Expect = 4.188e-36
Identity = 75/170 (44.12%), Postives = 96/170 (56.47%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLRKEVEVISISSKCSTNIQRQSISFDISSRDRLEAGPKPSYYDEIARSSS 228
            R TP    P  S +RP+IT QTY CP  YA WYCLNGATCF++KI ESILYNCECADGYMGQRCEFKD DG+YLP R+++ L+++         A  LV +  I   LY + R       +  E ++     K + N     +   +  +  LE G      D+  RSSS
Sbjct:    8 RSTPKPRPP-QSTVRPNITFQTYTCPETYAKWYCLNGATCFSIKIGESILYNCECADGYMGQRCEFKDLDGTYLPTRQRV-LIETASIAGGVTVAVILVFIVCITVYLYYQRRKDKTYFDVPDEPKLFFCDRKKTPN----QLPHPVLRQSDLERGRGVHMCDDSRRSSS 171          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|297499581|gb|ADI43984.1| (TGF-alpha, partial [Gryllus bimaculatus])

HSP 1 Score: 132.109 bits (331), Expect = 3.799e-35
Identity = 68/120 (56.67%), Postives = 83/120 (69.17%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQ 178
            R TP    P  +A RP+IT  TYACPPA+A WYCLNGATCF V I ES+LYNCECADGYMGQRCEFKD DGSYLP+R+++ L  +   G   +  F LV+L  I  A+Y   + K K ++
Sbjct:    6 RSTPKPRPPSPTA-RPNITFHTYACPPAHATWYCLNGATCFTVNIGESLLYNCECADGYMGQRCEFKDLDGSYLPSRQRVMLETASIAGGATIAVF-LVVLVCI--AVYIHFQRKLKESR 121          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|1067100329|ref|XP_018012256.1| (PREDICTED: uncharacterized protein LOC108669440 [Hyalella azteca])

HSP 1 Score: 139.428 bits (350), Expect = 4.999e-35
Identity = 68/116 (58.62%), Postives = 80/116 (68.97%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSP---GFGLIFLTAFGLVILAAILGALYTKHR 171
            R TP    P+   +RP+IT QTYACPPAYAAWYCLNGATCF VKIAESILYNCECADGYMGQRCE+KD DGSYLP   K+ L  +    G  L+ +  F  +  A  L    ++H+
Sbjct:  360 RSTPRPR-PLSPTLRPNITFQTYACPPAYAAWYCLNGATCFTVKIAESILYNCECADGYMGQRCEYKDLDGSYLPTGDKVLLETASIAGGAALVIILVFFGIFSAFALKNKRSQHK 474          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|1080046860|ref|XP_018564703.1| (PREDICTED: uncharacterized protein LOC108906047, partial [Anoplophora glabripennis])

HSP 1 Score: 132.109 bits (331), Expect = 3.390e-34
Identity = 74/169 (43.79%), Postives = 95/169 (56.21%), Query Frame = 0

Query:    9 WRSLLLFLVGVLLRGSEACSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLT 177
            W  LL+ LV  L+   +ACSS                             R TP    P  +  RP+IT  TY CPPAYAAWYCLNGATCF VKI +S+LYNCECA+G+MG RCE+KD DGSYLP++++  L  +   G   +  F +VIL  ++  L+ K RTK+  T
Sbjct:   55 WAFLLIVLVSSLISIVDACSS-----------------------------RTTPKPRPPAPTQ-RPNITFHTYQCPPAYAAWYCLNGATCFTVKIGDSLLYNCECAEGFMGPRCEYKDLDGSYLPSQRRFMLETASIAGGATVAVFSVVILCVVV-YLHYKRRTKATRT 192          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|1009573446|ref|XP_015918629.1| (PREDICTED: uncharacterized protein LOC107448055 [Parasteatoda tepidariorum])

HSP 1 Score: 133.265 bits (334), Expect = 4.431e-34
Identity = 67/118 (56.78%), Postives = 80/118 (67.80%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAI-RPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSK 175
            R TP    P   A  RP+IT QTYACP AYA WYCLNGATCFAVKI +SILYNCECADGYMGQRCEFKD DGSYLP+R++         G++ + AF    +A I   +Y   +++ K
Sbjct:   90 RSTPNRPRPTTIATTRPNITFQTYACPEAYAKWYCLNGATCFAVKIRDSILYNCECADGYMGQRCEFKDLDGSYLPSREREIQTAGIAGGVLIIVAF----IAFIYLIIYLMKKSRRK 203          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|1059409337|ref|XP_017777592.1| (PREDICTED: protein spitz-like isoform X3 [Nicrophorus vespilloides])

HSP 1 Score: 128.642 bits (322), Expect = 3.689e-33
Identity = 62/118 (52.54%), Postives = 83/118 (70.34%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKL 176
            R TP    P+ +A RP+IT  TYACPPAYAAWYCLN ATCF VKI +S+LYNCECADG+MG RCE+KD DGSYLP+++++ LL++         A   V +  ++  ++ K++ KS L
Sbjct:   36 RTTPKPRPPVPTA-RPNITFHTYACPPAYAAWYCLNEATCFTVKIRDSLLYNCECADGFMGPRCEYKDLDGSYLPSQRRI-LLETASIAGGATIAVLFVFILCVMAYVHYKNKMKSGL 151          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|646699974|gb|KDR10340.1| (hypothetical protein L798_15402, partial [Zootermopsis nevadensis])

HSP 1 Score: 126.331 bits (316), Expect = 3.922e-33
Identity = 61/122 (50.00%), Postives = 82/122 (67.21%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLTQLR 180
            R TP    P+ +A RP+IT  T+ CPPAY  WYCLNGATCF VKIA+S+LYNCECA+G++GQRCEFKD DGSY+P++++     +   G   +  F +VI+     A+Y   + K K T+ R
Sbjct:    7 RSTPKPRPPVPTA-RPNITFHTFPCPPAYNTWYCLNGATCFTVKIADSLLYNCECAEGFIGQRCEFKDLDGSYMPSKQRKMFQTASIAGGATIAVFLVVIVCV---AVYIHLQRKQKETRAR 124          

BLAST of EMLSAG00000012242 vs. nr
Match: gi|1058245254|gb|JAT26122.1| (hypothetical protein g.1609 [Graphocephala atropunctata])

HSP 1 Score: 127.872 bits (320), Expect = 4.973e-33
Identity = 59/103 (57.28%), Postives = 76/103 (73.79%), Query Frame = 0

Query:   75 DITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKLT 177
            +IT  TYACPPAYAA+YCLNGATCF VKI ES+LYNCECADGYMGQRCEFKD DGSYLP+R+++ L  +       +  F +VI+ A +   Y + + +++ T
Sbjct:   40 NITFHTYACPPAYAAFYCLNGATCFTVKIGESLLYNCECADGYMGQRCEFKDLDGSYLPSRQRVMLETASIASGATIAVFLVVIVCAFVYIHYQRRQKQNRAT 142          

BLAST of EMLSAG00000012242 vs. Tigriopus kingsejongenis genes
Match: maker-scaffold22_size673200-snap-gene-4.19 (protein:Tk12684 transcript:maker-scaffold22_size673200-snap-gene-4.19-mRNA-1 annotation:"TGF-alpha")

HSP 1 Score: 156.762 bits (395), Expect = 4.489e-46
Identity = 83/160 (51.88%), Postives = 109/160 (68.12%), Query Frame = 0

Query:   59 RXTPXXXSPIXSAIRPDITXQTYACPPAYAAWYCLNGATCFAVKIAESILYNCECADGYMGQRCEFKDPDGSYLPARKKLYLLKSPGFGLIFLTAFGLVILAAILGALYTKHRTKSKL--------TQLRK-EVEVISISSKC--STNIQRQSISFDISS 207
            R TP    P  +A+RP+IT QTYACPPAYAAWYCLNGATCF VKIA+SILYNCECADGYMGQRCEFKD DG+Y+PAR++L ++K+   G + +    +++   I+ A+ TK RT+ KL         QLR+ +   I +      + +I  QSIS+ +SS
Sbjct:  150 RSTPKPRPPSQNAMRPNITFQTYACPPAYAAWYCLNGATCFTVKIADSILYNCECADGYMGQRCEFKDLDGTYMPARERLMMIKNSKVGQVLILGIAVIVTVVIISAIATKIRTRIKLRTIATATVNQLRQNQFSSIGMGDNVLPAGDIMGQSISYQLSS 309