insulin receptor-2, maker-scaffold383_size189472-snap-gene-0.28 (gene) Tigriopus kingsejongensis
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Overview
Associated RNAi Experiments
Nothing found Homology
BLAST of insulin receptor-2 vs. L. salmonis genes
Match: EMLSAG00000002641 (supercontig:LSalAtl2s:LSalAtl2s1534:13768:20494:-1 gene:EMLSAG00000002641 transcript:EMLSAT00000002641 description:"maker-LSalAtl2s1534-augustus-gene-0.16") HSP 1 Score: 474.167 bits (1219), Expect = 4.268e-145 Identity = 362/1234 (29.34%), Postives = 577/1234 (46.76%), Query Frame = 0
Query: 31 HGEVCGS--ITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHL---DSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDG----CRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKT----------TFKDYQGKCLRQCPHNTKE---EEGTCITCS--DDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQLSGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDH-GQE--FSLTLLNNENLRKLFPTNASGQGIQI---------HKHE------GRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNT---TSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVV--ELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPP-------LMSSPNETETCDCSGCP---VQEEQLVQETISLVGTISQNMFNDLIMNSVF-----------RKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNIL-TKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAII--TWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWL----EQRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNAFSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGDIQVAIKMPHEDAGHLECMQFLQEAHLMK 1187
E+CG+ I + D+ LENCT+IEG++ + + EP + +L+FP ++EITD+ ++Y A+ SL+ LFPNLTVIRG++L+ A ++ NL +IGL+SLT ILRGGV I+ N LCYVHTINW+ IV + G + I+ +C C CP + H R CW K +++ E C+ ++G +E CS+ CLGGC G + C SC+ D CR+ CP FL+ + + CI ++C N Y+ K+ ++ Y C++ CP T++ +E +TC + CP VC G ++ ++ DL + CT I G L+I L GK++V LE L K+ +SLDFF SL I G + QE +SLT+L NEN++ LF + G+ I +K E G++++ G FIHYNP LC +I ++ + ++T + IS+ +NG+K IC +L ++ + ++ + ++ +QK I EQ+ +DIR LL Y++H++ + AT+ +NLT++DGRD AC D W I + P E + E + L S L++ L +P+TYY ++V TL++R+ I+GAQS I+YIQ P++ I ++++++ + W PPL PNG I HYE+ + E+ + C N E + P +S + CDC C +Q E ET + F+D+++N++F +G L R++RS+ G ++ + D + R F V + V A + L+HFG Y+V +RACH+ K NI CS ++ +V KP A+DI + L ++ SSS I+ +W PP DPN +I Y + ++K ++ + + C+ +F + +RY LPV G+Y+VSV+A+S G G W++ W+ + SV +++VP +F I A V + Y +++ + + NP Y Y AD+WE+ RN V + +G G F MV+KG + D+ A+K + A H E + FL EA +MK
Sbjct: 233 QSEICGNTKIKIMGDLQRDFKALENCTIIEGHLAIY-DIAEVEPSA---LSRKLSFPKLREITDFFIMYNANAFESLATLFPNLTVIRGDDLVMNYAFVVIYCNNLYEIGLRSLTHILRGGVRIEFNTRLCYVHTINWDMIVVGS-EGFIHIQRNENRNVCSDYCRDDCPL-LKNHLTRRACWTKATVKEVTFAIPCEEGLTCYQGNDGTRGSIEKCSKECLGGC---YGPSQEECYSCKHFLWQDNSKNYCRTTCPSPFLM------------------------FNDWICIDIKECRE--NSYIVNEKSITEKSITREMKYRIYNDSCIKGCPLGTQQITNKETRDLTCEKCEFCPKVCPGGKIRSLDDLHQYKECTHIDGDLSINLIGKSIVDGLESNLGKID--------------VSLDFFRSLRHIAGIHYPSQEKYYSLTILENENIQTLF---SFGEKPDIRVLITEQEQYKDENGDLVTGKQLS-GKTFIHYNPKLCPQKIVEMIKESQLSTDYDKADISEFTNGDKAICSHFKLNISTSLTVNGLNV-----SYDNYQKIIFEQNSTNDIRALLRYEIHYRIVDEATYLKKNLTQFDGRD--------ACGGDYWKIIDKVPSE---------------------------PQYESGNLVFLDESVLVSQL-------------------QPYTYYALYVATLMIRDIANRHNIQGAQSDILYIQTLESKPSKLGKYEIEKLSYSSVKIIWEPPLKPNGIITHYEMNITREIMDHNRIMERPYCQENYKIKEDYKDEQSNKDKDPDNLDSKKTVSVLSNLTKCDCDMCKAPEIQNEYEKSET---------DDFHDIVLNTIFTSNSISTPSSSNDSGQKKSELLRKKRSL-------------------------FGG--GQKLNDLNIDVKKRESF-VQNAIVAGSAREYIAEGLKHFGSYRVTLRACHEDK--KNIDPNDRCSDDLTVFLKVSNKPGADDIKGRPI--LVSHNSSSDIVWLSWNPPQDPNELIVNYNIKIESKSKE---STGIYCITAYEFIKNDYRYHLPVPGAYYVSVQAVSVYGFGEWSERTWVTVKGQSSSVVLYVMVPLVF-IFILAAAVALTYFYYKKHDDSEINISSNPRYISQNSVYKADEWEVPRNSVELLEELGNGCFGMVHKGIFIGPDKISRPCAVKTVKKGATHHETITFLIEATVMK 1309
BLAST of insulin receptor-2 vs. L. salmonis genes
Match: EMLSAG00000007374 (supercontig:LSalAtl2s:LSalAtl2s41:164202:216377:-1 gene:EMLSAG00000007374 transcript:EMLSAT00000007374 description:"maker-LSalAtl2s41-augustus-gene-2.12") HSP 1 Score: 90.5077 bits (223), Expect = 1.633e-18 Identity = 119/475 (25.05%), Postives = 197/475 (41.47%), Query Frame = 0
Query: 31 HGEVC----GSITLNSTNLSDYIHLE----NCTVIEGNVGVMIGLETFEPPEEVEVLARLTF-PNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALT-----ILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNK--NHCQKIQLEQCTTEDAHCHLDSQ-GEV--EVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGKCLRQCPHNTKEEEGTCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQLSGKNVVQ-----------------KLEEALSKVRIIEGSLKISRVF-SLISLDFFTSLEVIEGKDHGQEFS--------LTLLNNENLRKL 460
HG++C G +++ + Y +L NCT ++GN+ + T+ E ++ L+F +I+E+T Y+LI D + P+L +IRG L S ++ + + + +L IL G V I N LC++ TI WE I++ + + + E C C Q G CW + ++CQK C+ + CH GE+ E C C GGC +G + C +C++ + ECP + N I + + + + +Y ++CP K KD G C+R CP K G C+ C CP C EV +++ CT+I+G++ I S N Q K E + ++ + G + I + +L+ F +LEVI G+ + FS LT L ++LRK+
Sbjct: 78 HGKICIGTKGRMSVPNNREHHYRNLRDRYTNCTYVDGNLEL-----TWLQDENLD----LSFLQHIREVTGYVLISHVD---VRKIVLPSLQIIRGRTLFKLSVRDDKFSLMVTLSKMHYLEMPALRDILEGSVGILNNYNLCHIKTIEWEEIITGPRGKYVYVYNFNEPERDCTPCHESC-QSG--------CWGEGPSNCQKFSKINCSPQ---CHKGRCFGELPRECCHLFCAGGC---TGPKQSDCLACRNFFDDGVXKXECPP----MQRYNPIKY-------RWEKNPEGKYAYGATCVKECP----------KHLLKD-NGACVRICPPKKKTVNGECVPCDGPCPKTCHFNEVMHAGNIDSFQNCTVIEGSITILDSTFNGFQEXYENYTFGNRYPAMDPKKLEVFTTLKEVTGYINIQGHHPNFKNLNAFRNLEVIGGRTLTEYFSALYIVKTALTSLGLKSLRKI 503 HSP 2 Score: 56.6102 bits (135), Expect = 3.727e-8 Identity = 68/258 (26.36%), Postives = 105/258 (40.70%), Query Frame = 0
Query: 51 LENCTVIEGNVGVMIGL-----ETFE-----------PPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGE-SALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFE---CPGRCPQDGREHGKMRLCWNKNH-----CQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGS--NHTLCRSCQDVRTPDGCRSECPQDF 281
+NCTVIEG++ ++ E +E P+++EV F ++E+T Y+ I F NL VI G L SAL I++ L +GLKSL I G V+I N LCY INW++I+ L +++ C + C +C +G CW + C+K Q + L+ +C R C C + +G + +C+ C C EC D+
Sbjct: 398 FQNCTVIEGSITILDSTFNGFQEXYENYTFGNRYPAMDPKKLEV-----FTTLKEVTGYINIQGHHPNFKNLNAFRNLEVIGGRTLTEYFSALYIVKTA-LTSLGLKSLRKIRSGAVSILENKDLCYAQEINWQKIMKSPSHNTL-LQNNKNPQECIRQDHMCDPQCSAEG--------CWGPGNNSCLSCKKFQTQG--------KLEPLAGKAIC-RPCHSLCKKCNGYGFHDDVCQECVHFSQDQQCVPECDGDY 631
BLAST of insulin receptor-2 vs. L. salmonis genes
Match: EMLSAG00000009561 (supercontig:LSalAtl2s:LSalAtl2s615:613087:620800:1 gene:EMLSAG00000009561 transcript:EMLSAT00000009561 description:"maker-LSalAtl2s615-snap-gene-5.55") HSP 1 Score: 71.2478 bits (173), Expect = 1.460e-12 Identity = 43/118 (36.44%), Postives = 65/118 (55.08%), Query Frame = 0
Query: 1113 NPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGD--IQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
NP +EY +D +++ D +G+GAF V++G L +G+ VA+KM E+A F +EA L+ E P++V+L GV ++ P +L EYMA GDL S+L S P
Sbjct: 602 NPRLEKLEYPRND------IIYIRD-VGQGAFGRVFQGKAPGLKKGEEFTMVAVKMLKEEATDDLLRDFEKEAILLSEFDHPNIVRLYGVCAIGKPMCLLFEYMAKGDLNSYLRSNTP 712
BLAST of insulin receptor-2 vs. L. salmonis genes
Match: EMLSAG00000005080 (supercontig:LSalAtl2s:LSalAtl2s268:283763:286301:1 gene:EMLSAG00000005080 transcript:EMLSAT00000005080 description:"maker-LSalAtl2s268-augustus-gene-3.12") HSP 1 Score: 51.9878 bits (123), Expect = 9.101e-7 Identity = 33/106 (31.13%), Postives = 56/106 (52.83%), Query Frame = 0
Query: 1124 DDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQG-DIQVAIKMPHEDAGHLECMQFLQEAHLMKEI-KTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYR 1227
+ WEI+R+ + +G+G F V+KG + +G A+K E A +E L+E +MK + P+++ LIG + P V+LEY++ G L+ +L R
Sbjct: 276 EKWEISRHSIKILHMLGEGCFGQVWKG--EMIVEGISSTXAVKTFKESANEVEKKDLLKELSIMKMLGHHPNIITLIGCCTEKDPMFVVLEYVSGGTLQEYLRKSR 379
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|124531|sp|P15127.1|INSR_RAT (RecName: Full=Insulin receptor; Short=IR; AltName: CD_antigen=CD220; Contains: RecName: Full=Insulin receptor subunit alpha; Contains: RecName: Full=Insulin receptor subunit beta; Flags: Precursor) HSP 1 Score: 412.92 bits (1060), Expect = 1.090e-121 Identity = 372/1292 (28.79%), Postives = 587/1292 (45.43%), Query Frame = 0
Query: 6 GSEHQSITVVVVVLLLVQALNIPNTH---GEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGY------ESTLCPFECPG------RCPQDGREHGKMRLCWNKNHCQKI-----QLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCIS--KEDCPNIGNQYVGEVKTTFKDYQGKCLRQCP--HNTKEEEGTCITCSDDCPTVC----GGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKD-HGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTSHISDLS---NGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMSSP----NETETCD----CSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVF--RKT--GNTSRNL--NRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTD----YI--WLEQRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNA----FSTQNPNYCPME-------YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGDIQ--VAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
GS T V +L+ V H GEVC + + + NL+ LENC+VIEG++ +++ +T PE+ L+FP + ITDYLL++R L SL LFPNLTVIRG+ L AL I + +LK++GL +L I RG V I+ N LCY+ TI+W RI+ +ED Y ++ C CPG CP + CW +HCQK+ + CT E CH + CLG CS + T C +C++ C CP + + F FCQ H Y+C + K C +QYV + KC+ +CP + C C CP VC G + ++ ++L GCT+I G+L I + G N+ +LE L + I G LKI R ++L+SL FF L +I G+ +S L+N+NLR+L+ N KH + G F HYNP LC +EI ++ +G +D++ NG++ C+ L+ + +I+L++E + D R LLG+ + +K+ A +Q N+T +DG+D AC + W TV ++ QR N+ S +T W L ++P+T Y +FV TL+ + + GA+S I+Y+Q P+ P D V + + + + W PP PNG I HY V E + + + D + + + T +PP S N++E D C CP + Q+++E L + + F D + N VF RKT GN + + +R+RRS+++ +V T T + P P + P + R + V+ E+ L+++ L+HF Y+++++AC++ + + VS R P+ A+DI+ + N + + W P +PNG+I Y VS++ + D+E VS + + R P G+Y V VRA S +G G+WT+ Y+ +L+ S I++ L + F+V++ YL R++Q +++ NP Y Y+ D+WE+ R + +G+G+F MVY+G + +G+++ VA+K +E A E ++FL EA +MK HVV+L+GVVS P +V++E MA GDL+S L S RP E
Sbjct: 2 GSGRGCETTAVPLLMAVAVAGGTAGHLYPGEVCPGMDIRN-NLTRLHELENCSVIEGHLQILLMFKT--RPED---FRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDY-------VEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCH-----------KECLGNCSE--PDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFS----FCQDLH-------YKCRNSRKPGC----HQYV--------IHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWN---------KH-NLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRT----SFDKILLRWEPYWPP--------DFRDLLGFMLFYKE---APYQ--NVTEFDGQD--------ACGSNSW---------------TVVDIDPPQRSNDPKS---------------------------QTPSHPGW----LMRGLKPWTQYAIFVKTLV--TFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKG------LKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKE---LEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPSRKRRSLEEVGNV-TATTPTLPDFPNI---------------SSTIAPTSHEEHRPFEKVVNKES--LVISGLRHFTGYRIELQACNQDSPEER---SGVAAYVSA--RTMPEAKADDIVGPVTHEIFEN--NVVHLMWQEPKEPNGLIVLYEVSYR-RYGDEELHLCVSRKHFALERGCRLRGLSP--GNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAE 1124
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|408360149|sp|P15208.2|INSR_MOUSE (RecName: Full=Insulin receptor; Short=IR; AltName: CD_antigen=CD220; Contains: RecName: Full=Insulin receptor subunit alpha; Contains: RecName: Full=Insulin receptor subunit beta; Flags: Precursor) HSP 1 Score: 409.068 bits (1050), Expect = 2.201e-120 Identity = 360/1255 (28.69%), Postives = 572/1255 (45.58%), Query Frame = 0
Query: 32 GEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGY------ESTLCPFECPG------RCPQDGREHGKMRLCWNKNHCQKI-----QLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGKCLRQCP--HNTKEEEGTCITCSDDCPTVC----GGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKD-HGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTSHISDLS---NGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMSSP----NETETCD----CSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTD----YI--WLEQRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNA----FSTQNPNYCPME-------YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGDIQ--VAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
GEVC + + + NL+ LENC+VIEG++ +++ +T PE+ L+FP + ITDYLL++R L SL LFPNLTVIRG+ L AL I + +LK++GL +L I RG V I+ N LCY+ TI+W RI+ +ED Y ++ C CPG CP + CW +HCQK+ + CT E CH + CLG CS + T C +C++ C CP + + F FCQ H F+ ++ R K C +QYV + KC+ +CP + C C CP VC G + ++ ++L GCT+I G+L I + G N+ +LE L + I G LKI R ++L+SL FF L +I G+ +S L+N+NLR+L+ + S + I + G F HYNP LC +EI ++ +G +D++ NG++ C+ L+ + +I+L++E + D R LLG+ + +K+ A +Q N+T +DG+D AC + W TV ++ QR N+ S +T W L ++P+T Y +FV TL+ + + GA+S I+Y+Q P+ P D V + + + + W PP PNG I HY V E + + + D + + + T +PP S N++E D C CP + Q+++E L + + F D + N VF +R+RRS+++ +V T T + P P V P ++ R + V+ E+ L+++ L+HF Y+++++AC++ + CS R P+ A+DI+ + N + + W P +PNG+I Y VS++ + D+E VS + + R P G+Y V VRA S +G G+WT+ Y+ +L+ S I++ L + F+V++ YL R++Q +++ NP Y Y+ D+WE+ R + +G+G+F MVY+G + +G+ + VA+K +E A E ++FL EA +MK HVV+L+GVVS P +V++E MA GDL+S L S RP E
Sbjct: 32 GEVCPGMDIRN-NLTRLHELENCSVIEGHLQILLMFKT--RPED---FRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILD-------SVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCH-----------KECLGNCSE--PDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFS----FCQDLH--FKCRNSR---KPGC----HQYV--------IHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLW--DWSKHNLTITQ--------GKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRT----SFDKILLRWEPYWPP--------DFRDLLGFMLFYKE---APYQ--NVTEFDGQD--------ACGSNSW---------------TVVDIDPPQRSNDPKS---------------------------QTPSHPGW----LMRGLKPWTQYAIFVKTLVT--FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKG------LKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKE---LEESSFRKTFEDYLHNVVFVPRP------SRKRRSLEEVGNV-TATTLTLPDFPNV---------------SSTIVPTSQEEHRPFEKVVNKES--LVISGLRHFTGYRIELQACNQDSPDER-----CSVAAYVSARTMPEAKADDIVGPVTHEIFEN--NVVHLMWQEPKEPNGLIVLYEVSYR-RYGDEELHLCVSRKHFALERGCRLRGLSP--GNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAE 1113
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|82175202|sp|Q9PVZ4.1|INSR_XENLA (RecName: Full=Insulin receptor; Short=IR; AltName: Full=XTK-1b; AltName: Full=Xe-InsR; Contains: RecName: Full=Insulin receptor subunit alpha; Contains: RecName: Full=Insulin receptor subunit beta; Flags: Precursor) HSP 1 Score: 403.675 bits (1036), Expect = 1.823e-118 Identity = 351/1269 (27.66%), Postives = 580/1269 (45.71%), Query Frame = 0
Query: 10 QSITVVVVVLLLVQALNIPNTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEI-EDGYESTLCPFECPG------RCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDY---QGKCLRQCPHN--TKEEEGTCITCSDDCPTVC----GGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKD-HGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEI---ERLLSSAGMNTTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYES---PMTSTTTTSAPPLMSSPNETET-----CDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSS-SLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKF---KDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLE-----QRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNA-----FSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQG--DIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
+S+ ++ + +L+ + G++C S+ + + N+S + LE+CTVIEG++ +++ + T +P E L FP + ITDYLL++R L SL LFPNLTVIRG L AL I + + K+IGL +L I RG V I+ N LCY+ TI+W I+ +E+ D E C CPG +C + CW ++HCQK+ C + + C D Q C CLG C + + + C +C+ + C + CP+ +Q++ +RCI C + ++ + Y +G+C+ CP TC C+ CP VC + ++ ++L GCT+I G+L I L G N+ +LE L + I G LKI R ++L+SL FF L +I G+ +S L+N +LR+L+ HKH + G F H+NP LC ++I E + + G + I+ +NG++ C+ L N ++L+++ + D R LLG+ VH+K+ A FQ N+T +DG+D AC + W TV ++ +R + + SP +L++ ++P+T Y VFV TL+ EG GA+SKI+YI+ P+ P D V + + + + W PP PNG + HY V + +QP ED + Y + + S T T + + NE +T C CP E Q+ +E + + F + + N VF R + R+RR + + + + PP+ V S + PEP ++YS +V + + +L++ L+HF Y++++ AC+ L+ CS R P+ A+ ++ + ++ N + W P DPNG+I Y V H +++ E ++CV +++ K K R P G+Y V +RA S +G G+WT+ + + ++ I P I F +L+ + Y + ++K++ +++ NP Y YI D+WE+ R+ ++ +G+G+F MVY+G + +G +++VA+K +E A E ++FL EA +MK HVV+L+GVVS P +V++E MA GDL+S+L S RP E
Sbjct: 23 KSLVGIITIFMLILC---DQSDGKICYSMDIRN-NISQFSMLEDCTVIEGHLQILL-MFTSKP----ENFRGLRFPKLTTITDYLLLFRVYGLESLKDLFPNLTVIRGTRLFFNYALVIFEMVHXKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIELNRDNKEE--CGDVCPGTVKGKSKCKHTLVNGALVERCWTQDHCQKVCPSDC--KGSGCLPDGQ----CCHPECLGSCRKPNDPSE--CTACRHFQNEGVCVTACPK------------------------GSYQFQGWRCIDFNTCQELNSRCQNSRDNSCPPYVIHKGECMPDCPSGYIANSTTRTCTPCAGPCPKVCTIFQNVKTIDSVTSAQELRGCTVINGSLIINLRGGNNIATELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGEVLEAGNYSFYALDNPSLRQLW---------DWHKH-NLTIIHGKLFFHHNPRLCLSQIHQMEEVTGTKGRQDKNDIATKTNGDQASCEDNLLTFNFIKTSHDM----VLLRWDAYWPP--------DYRDLLGFMVHYKE---APFQ--NVTEFDGQD--------ACGSNSW---------------TVVDMDAPERSADGKTQ---------SPGCLLRS-------------------------LKPWTQYAVFVKTLVSGSDEG--RTYGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPPSEPNGNVTHYLVYWQ---EQP----EDSDLYEVDYCNKGLKLPSRTWTPPTEIDENGNENQTEHTSVNKCCPCPKTEFQIQKEQDE---SAFRKTFENYLHNEVF-----IPRPV-RKRRDLFGVANGTLPDPVTAPPLFNV------SSTRAPDEPEP----------KIYSQKVWFKES-VLISGLKHFTGYRIEIHACNHE------LSMGCSVAAYVNARTMPEATADKVVGPITYEYVEPN---IIHLKWQEPKDPNGLIVLYEV-HYSRVGGIEEV--ITCVSQKQYNTDKGGKLRVLTP--GNYSVKIRATSLAGNGSWTEQAYFQVPDHPHSNIVKIITGP---IIAVFLLLIVLVYCVVQKKKDAEGPAGPLYTSSNPEYLSASEVYIPDEWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLNEASVMKAFNCHHVVRLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAE 1112
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|2497556|sp|Q25410.1|MIPR_LYMST (RecName: Full=Putative molluscan insulin-related peptide(s) receptor; Contains: RecName: Full=Putative molluscan insulin-related peptide(s) receptor alpha chain; Contains: RecName: Full=Putative molluscan insulin-related peptide(s) receptor beta chain; Flags: Precursor) HSP 1 Score: 399.823 bits (1026), Expect = 5.566e-116 Identity = 327/1244 (26.29%), Postives = 560/1244 (45.02%), Query Frame = 0
Query: 34 VCGSITLNSTNLSDYIHLENCTVIEGNVGV-MIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERI-----VSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGK---CLRQCPHN-----TKEEE--GTCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQ-LSGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGK------DHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMN-TTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYE------SPMTSTTTTSAPPLMSSP---NETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVF-RKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSL-RHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWT-DYIWLEQRSVD--------WFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNAFSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQG---DIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
VCGS+ + S+ + ++ LENCTVIEG++ + + L+ + L+FP+++EITDYLL+YR L +LS+LFPNL +IRG EL A+ + + +L+D+GL +L TI RGGV + N LCY+ TINW +I +R F N E +CP C ++ + + CW + CQK QC E+ +C + C CLGGC N C SC++V+ + CR +CP +++ + RC++ ++C + N G +G+ CL CP N +K+ + C+ C CP C G E+ IQD KL C+ I G L IQ +SG NV Q+LE++L +R + ++ I R ++L++L FF +L++I K GQ FSL L++N NL++LFP Q+ K ++ G ++H N LC I+ LS ++ S IS +SNG++ C+ +L V + +L + + K D R LL Y +++K+I ++ ++ + GRD C D+W E+ P E EA ++ + +L P FT Y V++ + Y + A + I+ + P+EP D+ + + L V+W PP PNG I HY++V +N SYE P+ + N + +C CP +E++ +T S I + F D + ++ ++ ++ ++ + V +S D++ P++ + E + + + V T + L L+HF +Y ++V AC + +L+K CS R A+ I +++ + TN + + I W P+ PNG+I +Y++ +K +++ ++ + K+ ++ G++ + AIS + ++T + ++ R D +V + F +L +++V Y + + + ++N NY P E YI+D+WE++R+ + +G+G+F MVY+G + +I VA+K ++ A + +FL+EA MKE HVV+L+GVVS P +V++E MALGDL+++L +RP
Sbjct: 64 VCGSVDIRSS-MDNFKLLENCTVIEGSLRISLFELKALD-------FRHLSFPDLREITDYLLMYRVYGLETLSKLFPNLAIIRGRELFNSYAIVMYEMRDLQDLGLVNLRTISRGGVRLTKNFKLCYIETINWTQIGVSDPEARRFINNKE------------QCPNSC----KDECQSKRCWTYSDCQKGLNCQC-KENTYCMENGS----CCHDYCLGGCK--VPMNPDECFSCKEVQFNNTCRPQCPP------------------------GTYKFLNRRCLTDKECLALTNDPDGNTPKLLDGEKGEPSLCLYTCPQNYSVGDSKDNKNLSQCVKCRQLCPKECHGLEINNIQDAHKLKECSKISGPLKIQIMSGSNVAQELEKSLGNIREVTETIHIKRSYALVTLHFFKNLQIIGSKVPSSETQEGQSFSLFLMDNTNLQELFPEE------QMKK---MKILNGGIYVHDNGQLCPHTIKEFLSHLNLSEAQSSISSISNGHQRPCEKHDLNVT----VEKIAHNAAILAWNKY---------KADERQLLTYILNYKEIK---DESNDINIFQGRD--------LCSHDLWMTREYAPKEG----------PEADQIGMLY---------DLKP----------------------------------FTTYAVYI-----QAYTVSTATHAAMTNILTFTTYPFHPSEPTDLVAISEDPHELRVSWKPPKYPNGNITHYKIVY-----------HKLELNEKSYEQRNYCRDPLVHQKKKEKVKIEEEGKKINNSANSNCCKCPKSKEEM--DTESRKREI-EMYFEDYLHKHIYCKRYDKLPDEVDLNFDGMNLPQLVEMNYNSSE-------TSDRIEVFPNYVI---ENTSDLANLTEIVKEVVVYGTTEVTLPNLEHFSEYSIEVLACQDYN--EKVLSKLCSIRAITFERTKDSYAADMINETTVDTEIETNFTGNVFIKWESPTSPNGLILKYLLWYKKANQENLVPQTICITRQEYLKNLGYKLTRLEPGNWTFKISAISLAENSSFTLERFFIVPRPPDPESSNTLLIVAIVLAFFGVLTVSLIVACVYYKQKIRSDDMTVISRNMNYVPSEILYISDEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDRREFLKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRP 1135
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|2497557|sp|O02466.1|ILPR_BRALA (RecName: Full=Insulin-like peptide receptor; Short=ILP receptor; Contains: RecName: Full=Insulin-like peptide receptor alpha chain; Contains: RecName: Full=Insulin-like peptide receptor beta chain; Flags: Precursor) HSP 1 Score: 394.045 bits (1011), Expect = 4.835e-115 Identity = 363/1278 (28.40%), Postives = 555/1278 (43.43%), Query Frame = 0
Query: 11 SITVVVVVLLLVQALNIPNTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMR-LCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGKCLRQCPHNTKEEEGT---CITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMN----TTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHY--------EVVVELKTKQ-------PHVST---EDCVMNSPSYESPMTSTTTTSAPPLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTN------GSSSAIITWLPPSDPNGIIERYIVSHKAKMED-DESANSVSCVFPQKFKDSK-FRYQLPVEGSYFVSVRAISQSGRGNWTDYI--WLEQRSV-----DWFIVVPSLFAI---LAFAVLVCIGYL--IW---------RQKQNKNAFSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHL--DQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
++T+V+ + LLV + N +C S+ + + +S+ LENCTVIEG + +++ + EE + + L FPN+ EITDY L+YR LT+LS LFPNL VIRG L AL + + +++ IGL SL I RG V I+ NP LCY+ TI+W I + N I D E C CPGRC +H ++ LCW + HCQK+ E C +C G C NC+GGC G C +C+ C +CP D +QYK RCI++E+CPN N + +K + KC+ +CP + C C CP C G V ++ ++ GCTII+G L I + G N++ +LEE L + + + I R ++L++LDF SL+ I G ++ +L+N NL KLF + + I EG+ F H+NP LCR I ++ G+ T + IS L+NG++ C LE+ I+L++ F+ D R LL Y V +++ + + + YDG+DAC ++ + ++SP Q + +I L TQ L V+ +T G RE G K S I+Y + PT P+DV + + L +TW PP PNG + HY E V E++ ++ PH T ED V N E P ST C CP E+++ E F + N+V+ K N +R RRRR + T+ P V L S P P +P + V++ + ++L L+HF +Y ++V AC+ V CS + E R A++I P N A + W P PN ++ Y + +K D + CV KF S+ + V G+Y V RA S +G G+W++Y+ ++E+ D VP I + F++L+ + + IW +Q N +++ NP Y + Y+ D+WE+ R + +G+G+F MVY+G + D+ + VA+K +E A E ++FL EA +MK HVV+L+GVVS P +V++E MALGDL+++L +RP
Sbjct: 14 ALTLVIGLGLLVPS----NGEEYICDSMDIRN-RVSNLRQLENCTVIEGYLQILL----IDFAEEQD-YSGLAFPNLVEITDYFLLYRVRGLTNLSELFPNLAVIRGTNLFFNYALVVFEMLDMQKIGLYSLQNITRGSVRIEKNPNLCYLDTIDWSFIAESGYSNNF-IVDNREEEECVNFCPGRCRI---KHPVLQDLCWAEEHCQKVCPESCL---GNCRDGISG---CCHENCIGGC---DGPTERDCVACKYFVHNGECLIQCPPD------------------------TYQYKDRRCITEEECPNTTN-------SVWKLHHRKCIPECPSGYTTDINNPRLCTECEGQCPKSCKGGLVDSLAAAQRFRGCTIIEGELKISIRGGDNIIDELEENLGLIEEVGHYVAIVRSYALVTLDFLRSLKRIRGIQKENGYAFYVLDNRNLEKLFDWDRT----DITIDEGKL------FFHFNPKLCRHVILTMVDKVGLPEHAITDTDISTLTNGDQAQCSFSRLEIEEINTSKDM----IILRWSEFRPP--------DPRDLLSYTVSYRET-----EDQGIDEYDGQDAC--------------------------------------------GNTEWKEFDVSPT---QTAHIITGLKPWTQYALL---------VKTYTKAGA-------REGSGAK------SDIVYARTDADKPTHPQDVVVYSNSSNTLIITWKPPNRPNGNVTHYIVKYKRQQEDVAEMEQREYCKGGLKPHRPTQGLEDIVNNE---EEPNNSTIGDGT--------------CCECPKSEDEIRIEEEEAAFQQEFENF---LHNNVYHKRENETR-AGRRRREL---------PVTARPFYSNQTVNVTLPSTNRTVPPTPTPNPNPQLETTVWNEHM------VVLTGLRHFSEYIIEVIACNADAAVG------CSGSAVELARTQADDSADNI--------PGNITVVEIKEDMAKLYWPKPDSPNSMVVHYNIEYKKLGSDFNYEQQEPKCVENFKFLQSQGYTISNLVAGNYSVRFRATSFAGNGSWSNYVTFYVEEEDTSPDPQDPQQQVPVSLMIGMGVGFSLLLILAVIFGIWYCTKKRFGDKQMPNGVLYASVNPEYMSSDDVYVPDEWEVPREKITLIRELGQGSFGMVYEGEAKDVVKDEPMVSVAVKTVNESASIRERIEFLNEASVMKTFNCHHVVKLMGVVSKGQPTLVVMELMALGDLKNYLRRHRP 1091
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|205371763|sp|Q93105.2|INSR_AEDAE (RecName: Full=Insulin-like receptor; Short=MIR; Contains: RecName: Full=Insulin-like receptor alpha chain; Contains: RecName: Full=Insulin-like receptor beta chain; Flags: Precursor) HSP 1 Score: 393.66 bits (1010), Expect = 1.013e-114 Identity = 359/1287 (27.89%), Postives = 562/1287 (43.67%), Query Frame = 0
Query: 12 ITVVVVVLLLVQALNI------PNTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPG-------------RCP----QDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVC--SRNCLGGCSRHSGSNHTLCRSCQ-DVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGKCLRQCPHNTK-----EEEGTCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL---SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHG-QEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTSHISDLS-----NGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTST---TTTSAPPLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVD----QRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACH--------KAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSS--LRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVS-CVFPQKFKDSKFRYQLPVE-GSYFVSVRAISQSGRGNWTDYIWLEQRSVDWFIVVPSLFAILAFAVLVCIGYLI--WRQ----KQNKNAFSTQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHL--DQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
+++VV + +VQ + P G VCGS+ + ++ + L++C V+EG V +++ + + E +FP + EIT+YLL++R + L SL RLFPNL VIRG+ L+G+ A+ I + ++++IGL SL I RGGV I+ NP LC+ +TI+W+ + N I+D + +CP CP +CP + G + K LCWN NHCQ I +C + + VC + +CLGGC+ + S+ ++CR D C ++CP + F +C Y + IS + P++ +Q F + G CL +CP + + + C CS CP C G+ + IQ + L GC II G+L IQL G+N+V++LE LS + I+G LK+ R + L+SL F L++I GK + SL ++ N+NL++LF N + + G F NP LC +R+ + N I + S NG++ C ELE + + G ++Q+ F + D R LLGY +++ + A N+T +DGRDA C + W +++ +S + + + KI+ Q ++P+T Y +V T L G++ + G QSKI Y A P+ RDV V VN L V WLPPL NG + YEV +EL E ++ + + T TSAPP +S + C + C TI + +Q F D + N V+ K RR+RS + +TT +++ EP Y++ + + L+ H+ Y K+RAC +LVD L C V E R P K A+DI S + N + W PS PNG I +++V K + D ES +S C+ F ++ +E G+Y + V A + +G G + ++ D L L +G++ W + + + NP+Y ++Y DDWE+ RN + + +G+G+F MVYKG L ++ + AIK +E A E FL EA +MK+ T HVV+L+GVVS P +V++E MA GDL+S+L +RP E
Sbjct: 7 FSILVVPVAVVQGDEMKAGQVGPVPKGGVCGSVDVRNSP-AHLDRLKDCVVVEGFVHILLIDKYIDSSFE-----NYSFPLLTEITEYLLLFRVNGLKSLRRLFPNLAVIRGDALVGDYAMVIYELMHIEEIGLISLMDITRGGVRIEKNPKLCFANTIDWKAMTVPG--TNNYIKDNQKDNVCPI-CPAESTAVMLPNGSKQKCPAAPVRGGNKDHKRTLCWNANHCQTICPPECPK--------ACSKTGVCCDAESCLGGCNLPNTSSCSVCRHLSIDPAGKRQCVAKCPPN-------------TFKYHTRCVTRDECYAMKKPISLDSNPDLPDQ-------PFIPHNGSCLMECPLDHELITELNKTRWCRKCSGTCPKRCEGSNIDNIQSAQLLKGCEIIDGSLEIQLRSRGGENIVKELENFLSSITEIKGYLKVVRSYPLLSLGFLKKLKIIHGKGNKVSNSSLYVVENQNLQELFDHNVT-------------IGEGKLFFFNNPMLC---TDRIKAVKKYNPGIEIENESQLESNNGDRAACSITELETS----LKSIGSETAIIQWAPFTEL-------SDARMLLGYVIYYIEAPYA-----NVTFFDGRDA--------CNTEGWRLDD----------------------------ISDFNMDKETTKILTQ--------------------------LKPYTQYAYYVKTYTL----GSEGL-GGQSKIKYFTTAPGTPSVVRDVE-VSVNKNMLTVKWLPPLKMNGRLKEYEVFIELNAD----DNEQLMLRDYCEDDKLRDIVPETPTSAPPPKTSICTADQCR-NYCKAPTSGGSTGTIDVTDKENQITFEDQLHNYVYIKNPLLRDKTTRRKRSTNLLFPNNTENKKNDTTDR-------RTEKVKDEP---------------YYQYIFNATNETSITFPLSYFNHYSLYVFKIRACRHPGDPPAPSVRLVDVELA--CGNEVFENFRTPKKEGADDIPPESILIEEQSNNTQRQIRVQWKEPSKPNGPIVKFVV--KYQRVDLESVSSTDICIRYSSFNQTRGALLTKLEPGNYSIRVMATTIAGDGAPSAARYVLIAKDDSMGTTLIWLGTLIVIFLCSVGFVAFYWYKYRYMSKQIRMYPEVNPDYAGVQYKVDDWEVERNHIIQLEELGQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSFLLEASVMKQFNTHHVVRLLGVVSQGDPTLVIMELMANGDLKSYLRRHRPDYE 1125
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|2827762|sp|P24062.2|IGF1R_RAT (RecName: Full=Insulin-like growth factor 1 receptor; AltName: Full=Insulin-like growth factor I receptor; Short=IGF-I receptor; AltName: CD_antigen=CD221; Contains: RecName: Full=Insulin-like growth factor 1 receptor alpha chain; Contains: RecName: Full=Insulin-like growth factor 1 receptor beta chain; Flags: Precursor) HSP 1 Score: 385.956 bits (990), Expect = 3.928e-112 Identity = 335/1264 (26.50%), Postives = 548/1264 (43.35%), Query Frame = 0
Query: 18 VLLLVQALNIPNTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPG------RCPQDGREHGKMRLCWNKNHCQKIQLEQC----TTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGKCLRQCPHN---TKEEEGTCITCSDDCPTVCGGAE-----VTTIQDLEKLNGCTIIKGTLAIQLS-GKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQ-EFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERL---LSSAGMNTTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHV-----STEDCVMNSPSYESPMTSTTTTSAPPLMSSPNETETCD-----CSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRAC-HKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSS-SLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLEQRSVDWFIVVPSLFAILAFAVLVCIG------YLIWRQKQNKNA-----FSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHL--DQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
++ L AL++ T GE+CG + LENCTVIEG + +++ + E FP + IT+YLL++R L SL LFPNLTVIRG +L AL I + NLKDIGL +L I RG + I+ N LCY+ TI+W I+ N I C CPG C + + CW N CQK+ C TE+ C C CLG C H+ ++T C +C+ C CP ++++ +RC+ ++ C NI N + F + G+C+++CP + CI C CP VCG E + ++ + L GCTI+KG L I + G N+ +LE + + ++ G +KI +L+SL F +L +I G++ + +S +L+N+NL++L+ N H V G + +NP LC +EI R+ + G + I+ +NG + C+ L +T I++ + ++ D R L+ + V++K+ A F+ N+T YDG+DA C + W++ +V E P I+L ++P+T Y V+V + L E IRGA+S+I+YI+ P+ P DV + + L V W PP PNG + +Y V + + + ++ ++D + + + T P +TE C C CP + ++ + +F + + NS+F RRRR V Q + + + V + ++ + +PE E + + + +RV + ++ N L+ F Y++ + +C H+A+ + CS + R P A+DI + P N S + W P +PNG+I Y + + +++ED VS +K+ +K P G+Y ++A S SG G+WTD ++ + + L L A+L+ +G Y+ R++ N +++ NP Y Y+ D+WE+ R + +G+G+F MVY+G + D+ + +VAIK +E A E ++FL EA +MKE HVV+L+GVVS P +V++E M GDL+S+L S RP E
Sbjct: 16 LVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILL-------ISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAV--SNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNEC----------CHPECLGSC--HTPDDNTTCVACRHYYYKGVCVPACPP------------------------GTYRFEGWRCVDRDFCANIPNAESSD-SDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWN----------HRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKN----RIIITWHRYRPP--------DYRDLISFTVYYKE---APFK--NVTEYDGQDA--------CGSNSWNM----------------------------VDVDLPPNKEGEPGILLHG-------------------------LKPWTQYAVYVKAVTLTMVENDH-IRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENP-------KTEVCGGDKGPCCACP---KTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPE------RRRRDVLQVANTTMSSRSRNTTVAD-----------TYNITDPE---EFETEYPFFESRVDNKERTVISN-LRPFTLYRIDIHSCNHEAEKLG------CSASNFVFARTMPAEGADDIPGPVTWEPRPEN---SIFLKWPEPENPNGLILMYEIKYGSQVEDQREC--VSRQEYRKYGGAKLNRLNP--GNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVE 1100
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|12644455|sp|Q60751.3|IGF1R_MOUSE (RecName: Full=Insulin-like growth factor 1 receptor; AltName: Full=Insulin-like growth factor I receptor; Short=IGF-I receptor; AltName: CD_antigen=CD221; Contains: RecName: Full=Insulin-like growth factor 1 receptor alpha chain; Contains: RecName: Full=Insulin-like growth factor 1 receptor beta chain; Flags: Precursor) HSP 1 Score: 383.645 bits (984), Expect = 2.739e-111 Identity = 339/1265 (26.80%), Postives = 551/1265 (43.56%), Query Frame = 0
Query: 18 VLLLVQALNIPNTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPG------RCPQDGREHGKMRLCWNKNHCQKIQLEQC----TTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGKCLRQCPHN---TKEEEGTCITCSDDCPTVCGGAE-----VTTIQDLEKLNGCTIIKGTLAIQLS-GKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQ-EFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERL---LSSAGMNTTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYES----PMT--STTTTSAPPLMSSPNETETCD-----CSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRAC-HKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSS-SLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLEQRSVDWFIVVPSLFAILAFAVLVCIG------YLIWRQKQNKNA-----FSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHL--DQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
++ L AL++ T GE+CG + LENCTVIEG + +++ + E FP + IT+YLL++R L SL LFPNLTVIRG +L AL I + NLKDIGL +L I RG + I+ N LCY+ TI+W I+ N I C CPG C + + CW N CQK+ C TE+ C C CLG C H+ ++T C +C+ C CP ++++ +RC+ ++ C NI N + F + +C+++CP + CI C CP VCG E + ++ + L GCTI+KG L I + G N+ +LE + + ++ G +KI +L+SL F +L +I G++ + +S +L+N+NL++L+ N H V G + +NP LC +EI R+ + G + I+ +NG + C+ L +T I++ + ++ D R L+ + V++K+ A F+ N+T YDG+DA C + W++ +V E P I+L ++P+T Y V+V + L E IRGA+S+I+YI+ P+ P DV + + L V W PP PNG + +Y V + +QP +D + +Y S P+ + T + +P +TE C C CP + ++ + +F + + NS+F RRRR V Q + + + V + ++ + +PE E + + + +RV + ++ N L+ F Y++ + +C H+A+ + CS + R P A+DI + P N S + W P +PNG+I Y + + +++ED VS +K+ +K P G+Y ++A S SG G+WTD ++ + + L L A+L+ +G Y+ R++ N +++ NP Y Y+ D+WE+ R + +G+G+F MVY+G + D+ + +VAIK +E A E ++FL EA +MKE HVV+L+GVVS P +V++E M GDL+S+L S RP E
Sbjct: 16 LVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILL-------ISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAV--SNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNEC----------CHPECLGSC--HTPDDNTTCVACRHYYYKGVCVPACPP------------------------GTYRFEGWRCVDRDFCANIPNAESSD-SDGFVIHDDECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWN----------HRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKN----RIIITWHRYRPP--------DYRDLISFTVYYKE---APFK--NVTEYDGQDA--------CGSNSWNM----------------------------VDVDLPPNKEGEPGILLHG-------------------------LKPWTQYAVYVKAVTLTMVENDH-IRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQ---RQP----QDGYLYRHNYCSKDKIPIRKYADGTIDVEEVTENP-KTEVCGGDKGPCCACP---KTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPE------RRRRDVMQVANTTMSSRSRNTTVAD-----------TYNITDPE---EFETEYPFFESRVDNKERTVISN-LRPFTLYRIDIHSCNHEAEKLG------CSASNFVFARTMPAEGADDIPGPVTWEPRPEN---SIFLKWPEPENPNGLILMYEIKYGSQVEDQREC--VSRQEYRKYGGAKLNRLNP--GNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVE 1100
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|308153655|sp|P06213.4|INSR_HUMAN (RecName: Full=Insulin receptor; Short=IR; AltName: CD_antigen=CD220; Contains: RecName: Full=Insulin receptor subunit alpha; Contains: RecName: Full=Insulin receptor subunit beta; Flags: Precursor) HSP 1 Score: 370.548 bits (950), Expect = 1.181e-106 Identity = 345/1271 (27.14%), Postives = 562/1271 (44.22%), Query Frame = 0
Query: 32 GEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGY------ESTLCPFECPG------RCPQDGREHGKMRLCWNKNHCQKI-----QLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDY---QGKCLRQCP--HNTKEEEGTCITCSDDCPTVC----GGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKD-HGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTSHISDLS---NGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDI--------------WHINEFQP-VESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVF--RK----TGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTD----YI--WLEQRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNA----FSTQNPNYCPME-------YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGDIQ--VAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
GEVC + + + NL+ LENC+VIEG++ +++ +T PE+ L+FP + ITDYLL++R L SL LFPNLTVIRG+ L AL I + +LK++GL +L I RG V I+ N LCY+ TI+W RI+ +ED Y ++ C CPG CP + CW +HCQK+ + CT E CH + CLG CS+ + T C +C++ C CP + + ++ +RC++ C ++ ++ + Y KC+ +CP + C C CP VC G + ++ ++L GCT+I G+L I + G N+ +LE L + I G LKI R ++L+SL FF L +I G+ +S L+N+NLR+L+ + S + I + G F HYNP LC +EI ++ +G +D++ NG++ C+ L+ + +I+L++E + D R LLG+ + +K+ A +Q N+T +DG+DAC + + D W + +P + I T+ S+ +R + S++ +P + L S+ NS +Q+ L W S T+Y VF R+ E ++ ++ Y + P+ TW PP E + Q H +E E +C CP + Q+++E L + + F D + N VF RK TG +R+RRS+ +V VP V + S PE E R + +V V+ E+ L+++ L+HF Y+++++AC++ + + CS R P+ A+DI+ + N + + W P +PNG+I Y VS++ + D+E VS + + R P G+Y V +RA S +G G+WT+ Y+ +L+ S I++ L + F+V++ YL R++Q +++ NP Y Y+ D+WE++R + +G+G+F MVY+G + +G+ + VA+K +E A E ++FL EA +MK HVV+L+GVVS P +V++E MA GDL+S+L S RP E
Sbjct: 32 GEVCPGMDIRN-NLTRLHELENCSVIEGHLQILLMFKT--RPED---FRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILD-------SVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSE-----------CLGNCSQ--PDDPTKCVACRNFYLDGRCVETCPPPY------------------------YHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLW--DWSKHNLTITQ--------GKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRT----SFDKILLRWEPYWPP--------DFRDLLGFMLFYKE---APYQ--NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNS---SSQIILKWKPP--SDPNGNITHYLVFWE----RQAEDSELF-----ELDYCLKGLKLPSR----------------TWSPPF-------------ESEDSQKHNQSE----------------------------YEDSAGECCSCPKTDSQILKE---LEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVA-------VPTVAAFPNTSSTSVPTSPE-----EHRPFEKV----VNKES--LVISGLRHFTGYRIELQACNQ-----DTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFEN--NVVHLMWQEPKEPNGLIVLYEVSYR-RYGDEELHLCVSRKHFALERGCRLRGLSP--GNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAE 1123
BLAST of insulin receptor-2 vs. SwissProt
Match: gi|124240|sp|P08069.1|IGF1R_HUMAN (RecName: Full=Insulin-like growth factor 1 receptor; AltName: Full=Insulin-like growth factor I receptor; Short=IGF-I receptor; AltName: CD_antigen=CD221; Contains: RecName: Full=Insulin-like growth factor 1 receptor alpha chain; Contains: RecName: Full=Insulin-like growth factor 1 receptor beta chain; Flags: Precursor) HSP 1 Score: 369.392 bits (947), Expect = 2.899e-106 Identity = 332/1252 (26.52%), Postives = 542/1252 (43.29%), Query Frame = 0
Query: 30 THGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPG------RCPQDGREHGKMRLCWNKNHCQKIQLEQC----TTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDYQGKCLRQCPHN---TKEEEGTCITCSDDCPTVCGGAEVT----TIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQ-EFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERL---LSSAGMNTTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYES----PMT--STTTTSAPPLMSSPNETETCD-----CSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRAC-HKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSS-SLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLEQRSVDWFIVVPSLFAILAFAVLVCIG------YLIWRQKQNKN-----AFSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHL--DQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTE 1231
T GE+CG + LENCTVIEG + +++ + E FP + IT+YLL++R L SL LFPNLTVIRG +L AL I + NLKDIGL +L I RG + I+ N LCY+ T++W I+ N I C CPG C + + CW N CQK+ C TE+ C C CLG CS + N T C +C+ C CP + ++++ +RC+ ++ C NI + + + F + G+C+++CP + CI C CP VC + T ++ + L GCTI KG L I + G N+ +LE + + ++ G +KI +L+SL F +L +I G++ + +S +L+N+NL++L+ + H + G + +NP LC +EI R+ + G + I+ +NG + C+ L +T I++ + ++ D R L+ + V++K+ A F+ N+T YDG+DAC SN ++L P ++ L++ L TQ Y V+V + L E IRGA+S+I+YI+ P+ P DV + + L V W PP PNG + +Y V + +QP +D + +Y S P+ + T + +P +TE C C CP + ++ + +F + + NS+F R+RR V Q + + + + ++ + +PE E + + + +RV + ++ N L+ F Y++ + +C H+A+ + CS + R P A+DI + P N S + W P +PNG+I Y + + +++ED VS +K+ +K P G+Y ++A S SG G+WTD ++ ++ + L L AVL+ +G Y+ R++ N +++ NP Y Y+ D+WE+ R + +G+G+F MVY+G + D+ + +VAIK +E A E ++FL EA +MKE HVV+L+GVVS P +V++E M GDL+S+L S RP E
Sbjct: 28 TSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILL-------ISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAV--SNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNEC----------CHPECLGSCS--APDNDTACVACRHYYYAGVCVPACPPN------------------------TYRFEGWRCVDRDFCANILSAESSDSE-GFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWD----------HRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSK----NRIIITWHRYRPP--------DYRDLISFTVYYKE---APFK--NVTEYDGQDAC------------------------------------------GSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQ-------------------YAVYVKAVTLTMVENDH-IRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQ---RQP----QDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENP-KTEVCGGEKGPCCACP---KTEAEKQAEKEEAEYRKVFENFLHNSIFVPRP------ERKRRDVMQVANTTMSSRSRNTTAAD-----------TYNITDPE---ELETEYPFFESRVDNKERTVISN-LRPFTLYRIDIHSCNHEAEKLG------CSASNFVFARTMPAEGADDIPGPVTWEPRPEN---SIFLKWPEPENPNGLILMYEIKYGSQVEDQREC--VSRQEYRKYGGAKLNRLNP--GNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEME 1099
BLAST of insulin receptor-2 vs. nr
Match: gi|1325298287|ref|XP_023331393.1| (insulin-like growth factor 1 receptor isoform X2 [Eurytemora affinis]) HSP 1 Score: 516.924 bits (1330), Expect = 1.309e-154 Identity = 371/1275 (29.10%), Postives = 629/1275 (49.33%), Query Frame = 0
Query: 17 VVLLLVQALNIPNTHGEVC-GSITLN-STNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFF--GNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQC------TTEDAHCHLDSQGEVEV-CSRNCLGGCSRHSGSNHTLCRSCQDV-----RTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQ--YVGEVK-----TTFKDYQGKCLRQCPHN---TKEEEGTCITCS--DDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQLSGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTS--HISDLSNGNKGICDPLELEVNATAQISPFGI--PEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVG-VNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMSSPNETETCDCSGCPV-QEEQLVQETISLVGT--ISQNMFNDLIMNSVFR------KTGNTSRNLNRRRRSVDQRESVPTKE--TTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAK-----LVDN-ILTKWCSPTVSERPRVPPKPMANDILSSSLRH---LPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSV-SCVFPQK---FKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLE-QRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQN---KNAFSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
+VL+ +L N +VC +I +N TN +D NCTV+EG++ + L ++ E+ +FP++ EITDYLL+YRA+++ +L+ + P L VIRG+ L+ AL I Q +N++ +GL SLT I++GGV I+ NP LCYV TI+W +IV ++ IE+ + C C C + CW++++CQ I+L +C + C+ D+QGE +V CS C+GGCS + H C +C+++ C +CP+ L YK+++CI++E C N+ N Y E K T + +C+ +CP N TK++ C+ +CP C G + + ++ E+ CT I G L I++S ++ LE+ + ++ I G+LKISR F+L+SL FF SLE+I+G++ ++FS+T++ NENL+KLFP N +V G FIHYN LC EI + +G+ +S ++NGNK +C +L N T GI + +FE +++ + + + D+ L+GY++++++IS + A+N+++++G D AC + W++ + +P + N+ + + + +Q P ++ + P+ ++PFT Y V+ TTL++ T GAQS I+Y + P + R++ ++ L ++W PP P+G IDHY++++E ++ +D N +Y S A ++ P +T +C C +++ I G I + +F ++N +F G + R++ S+ Q P +E + V Y+ + +E S+ + + + RV T ++L L+HF YQVKV AC + VDN I+ K CSP + + PKP A+DI+ + P + I W PP DPN +I Y + K+ M DD S + + C+ + D + Y L EG Y +S+RA+S G WT + ++ + + ++ + + +L + +G+++ +K+N + ++NP+Y Y D+WE+ R+L+ G+ +G G+F + +KG Y++ D+G + VAIK E A + ++FL EA +MKEI T HVV+L+GVVS P +VL+E M GDLR +L S RP
Sbjct: 325 IVLINSCSLVAANQGPQVCVANININHKTNWADLAKYSNCTVLEGSLQINSALLDYQKAEDN---LNFSFPHLVEITDYLLLYRANQIENLTSVLPKLAVIRGHRLINNYALAIYQMKNMRTLGLLSLTNIMKGGVRIEKNPSLCYVETIDWRQIVIDPIHKKSHIFIEENMDEQACSDTCKPSCENN---------CWDEDNCQ-IKLVKCPGGIDGSAGQDECYADNQGEPKVPCSAECIGGCSAKTSPEH--CYACRNLWYQLQNNSTVCVEKCPEGLL------------------------SYKNWKCITEEACSNLENDGGYREEDKFYKIHTDLNRQEQQCVAECPANYQGTKDQNAKRWECTPCQNCPRHCDGGVINSREEAERFLHCTHITGELEIRVSEGDITPVLEDTMKDIKEISGTLKISRSFALVSLYFFKSLELIKGENTNEKFSITIMENENLQKLFPGNV-------------KVEAGKAFIHYNQKLCMEEINNFIEKSGLRKPGVYEVSSVTNGNKAVCSKEKLWFNIT------GIHGRAFVFEFENYRQNLYLR-AEEDVNALIGYEIYYREISEEQYVAKNISKFEGLD--------ACGGNTWNVQDRRPSD---------NLGTCENSKDCNLPANQDD----FPILVYK------------------PETGWIFDLKPFTPYAVYATTLMVPHLATNAT--GAQSDIVYFRTDSEPPEQVRNLKWSAEETYSKLRISWSPPRRPHGIIDHYDIMLE------YIPLKDIAKNR-NYCSKKPEDKPEKAEIVVPKPKVNDTSNCPLCQCSKDDGKNYNKIEDFGDEHIDEQVFYSDLINKIFTIPITIGGGGKSKRSIRSGAESL-QLLGQPEEEKYVRVNTKTASVQSYENVYNETSFI--------NGSNVYGILYERVSGNQTEIVLKDLKHFALYQVKVMACQAERKYDLDCVDNCIMQKDCSPWSIDEAKTRPKPNADDIIVDDNKLEIIFPNETTGDTYIRWRPPQDPNEMIVHYTLRRKSSMSDDASNSYMEQCISLNQLIELDDGRVEYHLTTEGEYLISLRAVSLYSSGGWTSWQKVKVKTTASYYWIAIVVVILLLLIAGLMVGFVVRHKKKNPILEWEIVSRNPDYLDTGCVYQMDEWEVPRDLIIKGEELGSGSFGVCHKGIYNYPDKGPVSVAIKTVPERATFRQRIEFLNEASVMKEINTAHVVKLLGVVSQGQPTLVLMELMENGDLRKYLRSLRP 1483
BLAST of insulin receptor-2 vs. nr
Match: gi|1325298282|ref|XP_023331392.1| (insulin-like growth factor 1 receptor isoform X1 [Eurytemora affinis]) HSP 1 Score: 516.924 bits (1330), Expect = 1.911e-154 Identity = 371/1275 (29.10%), Postives = 629/1275 (49.33%), Query Frame = 0
Query: 17 VVLLLVQALNIPNTHGEVC-GSITLN-STNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFF--GNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQC------TTEDAHCHLDSQGEVEV-CSRNCLGGCSRHSGSNHTLCRSCQDV-----RTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQ--YVGEVK-----TTFKDYQGKCLRQCPHN---TKEEEGTCITCS--DDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQLSGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTS--HISDLSNGNKGICDPLELEVNATAQISPFGI--PEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVG-VNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMSSPNETETCDCSGCPV-QEEQLVQETISLVGT--ISQNMFNDLIMNSVFR------KTGNTSRNLNRRRRSVDQRESVPTKE--TTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAK-----LVDN-ILTKWCSPTVSERPRVPPKPMANDILSSSLRH---LPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVS-CVFPQK---FKDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLE-QRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQN---KNAFSTQNPNYCPME--YIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
+VL+ +L N +VC +I +N TN +D NCTV+EG++ + L ++ E+ +FP++ EITDYLL+YRA+++ +L+ + P L VIRG+ L+ AL I Q +N++ +GL SLT I++GGV I+ NP LCYV TI+W +IV ++ IE+ + C C C + CW++++CQ I+L +C + C+ D+QGE +V CS C+GGCS + H C +C+++ C +CP+ L YK+++CI++E C N+ N Y E K T + +C+ +CP N TK++ C+ +CP C G + + ++ E+ CT I G L I++S ++ LE+ + ++ I G+LKISR F+L+SL FF SLE+I+G++ ++FS+T++ NENL+KLFP N +V G FIHYN LC EI + +G+ +S ++NGNK +C +L N T GI + +FE +++ + + + D+ L+GY++++++IS + A+N+++++G D AC + W++ + +P + N+ + + + +Q P ++ + P+ ++PFT Y V+ TTL++ T GAQS I+Y + P + R++ ++ L ++W PP P+G IDHY++++E ++ +D N +Y S A ++ P +T +C C +++ I G I + +F ++N +F G + R++ S+ Q P +E + V Y+ + +E S+ + + + RV T ++L L+HF YQVKV AC + VDN I+ K CSP + + PKP A+DI+ + P + I W PP DPN +I Y + K+ M DD S + + C+ + D + Y L EG Y +S+RA+S G WT + ++ + + ++ + + +L + +G+++ +K+N + ++NP+Y Y D+WE+ R+L+ G+ +G G+F + +KG Y++ D+G + VAIK E A + ++FL EA +MKEI T HVV+L+GVVS P +VL+E M GDLR +L S RP
Sbjct: 348 IVLINSCSLVAANQGPQVCVANININHKTNWADLAKYSNCTVLEGSLQINSALLDYQKAEDN---LNFSFPHLVEITDYLLLYRANQIENLTSVLPKLAVIRGHRLINNYALAIYQMKNMRTLGLLSLTNIMKGGVRIEKNPSLCYVETIDWRQIVIDPIHKKSHIFIEENMDEQACSDTCKPSCENN---------CWDEDNCQ-IKLVKCPGGIDGSAGQDECYADNQGEPKVPCSAECIGGCSAKTSPEH--CYACRNLWYQLQNNSTVCVEKCPEGLL------------------------SYKNWKCITEEACSNLENDGGYREEDKFYKIHTDLNRQEQQCVAECPANYQGTKDQNAKRWECTPCQNCPRHCDGGVINSREEAERFLHCTHITGELEIRVSEGDITPVLEDTMKDIKEISGTLKISRSFALVSLYFFKSLELIKGENTNEKFSITIMENENLQKLFPGNV-------------KVEAGKAFIHYNQKLCMEEINNFIEKSGLRKPGVYEVSSVTNGNKAVCSKEKLWFNIT------GIHGRAFVFEFENYRQNLYLR-AEEDVNALIGYEIYYREISEEQYVAKNISKFEGLD--------ACGGNTWNVQDRRPSD---------NLGTCENSKDCNLPANQDD----FPILVYK------------------PETGWIFDLKPFTPYAVYATTLMVPHLATNAT--GAQSDIVYFRTDSEPPEQVRNLKWSAEETYSKLRISWSPPRRPHGIIDHYDIMLE------YIPLKDIAKNR-NYCSKKPEDKPEKAEIVVPKPKVNDTSNCPLCQCSKDDGKNYNKIEDFGDEHIDEQVFYSDLINKIFTIPITIGGGGKSKRSIRSGAESL-QLLGQPEEEKYVRVNTKTASVQSYENVYNETSFI--------NGSNVYGILYERVSGNQTEIVLKDLKHFALYQVKVMACQAERKYDLDCVDNCIMQKDCSPWSIDEAKTRPKPNADDIIVDDNKLEIIFPNETTGDTYIRWRPPQDPNEMIVHYTLRRKSSMSDDASNSYMEQCISLNQLIELDDGRVEYHLTTEGEYLISLRAVSLYSSGGWTSWQKVKVKTTASYYWIAIVVVILLLLIAGLMVGFVVRHKKKNPILEWEIVSRNPDYLDTGCVYQMDEWEVPRDLIIKGEELGSGSFGVCHKGIYNYPDKGPVSVAIKTVPERATFRQRIEFLNEASVMKEINTAHVVKLLGVVSQGQPTLVLMELMENGDLRKYLRSLRP 1506
BLAST of insulin receptor-2 vs. nr
Match: gi|1046754412|gb|ANW09593.1| (insulin receptor 1 [Monochamus alternatus]) HSP 1 Score: 487.649 bits (1254), Expect = 2.830e-146 Identity = 374/1247 (29.99%), Postives = 587/1247 (47.07%), Query Frame = 0
Query: 34 VCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIV----SRAFFGNLEIEDGYESTLCPFECPGR-----------CPQDGREHGK-----MRLCWNKNHCQKIQLEQCTT--EDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGN--QYVGEVKTTFKDYQGKCLRQCPHNTKEEEGTCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEG-KDHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTSHISDL-----SNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMS---SPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQ------VPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSV-SCVFPQKF-KDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLEQRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQ----NKNAFSTQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLD-QGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTEAF 1233
+C S+ + ++ L + L NC VIEG + +++ F+ E + L ++ FP + EITDYLL+YR L S+ +LFPNL+VIRG L +A I + +L++IGL SLT I G V I NP LC+VHTI+W+RIV +F +L+ E+ E +CP + CP+ R G LCWNK HCQKI + CT + HC C CLGGCS ++ C C++ + EC Q C S F+Y RCI+KE+C N+ ++ + +K + C+ CP N K TC+ C C +C G V +I ++L GCT IKG+L IQ+ +G NVV LEE L+ + I G LK+ R FSL+SL+F SL+ I+G K Q++ +L+N+NL++L+ + + ++IH G F H+NP LC +IE+L A M H +DL SNG++ C+ +L V T S + I L++ F+ + D R LL Y ++ + ++N+T YDGRDA C +D W RV + + S+ ++ P + +P+TYY +V T Y GAQS+IMY + P+ P+++ ++ + +L ++WLPP PNG+I HY V + + H++ + + S + T T AP ++ SP +TC C+ P E L +I+ + ++ F D + N V+ + +++ + TK T+ P P + PS++ V E D F VY T ++ L HF Y + V+AC K + +++ ++ CS T + R K A+ I + H+ + + W PP DPNG+I + +KA D+ +A C+ +F DS + LP G+Y + V A + +G G ++ YI++ VV ++ F ++ G I+R++Q N + NP Y P YI D+WE+ R + +G+G+F MV++G H + Q +++ AIK +E A + E ++FL EA +MK T HVV+L+GVVS P +V++E MA GDL+S+L S+RP E +
Sbjct: 65 ICKSVDVRNS-LDAFSKLHNCEVIEGFLQILL----FDNVSEGDFL-KMQFPLLTEITDYLLLYRVSGLRSIGQLFPNLSVIRGQNLFFSNAFVIFEMSSLQEIGLYSLTDITHGAVRIDKNPSLCFVHTIDWDRIVHDKKETSFIKSLKPEN--ECPICPGNVDAKADGENNSVTVACPKAPRTSGDNFEKDKHLCWNKRHCQKICPDNCTACNDLGHC----------CGPLCLGGCSNDDPND---CTVCKNFAVETERKRECTQ--------------------SCPPSYFKYLDRRCITKEECINMPKPIEFHATNEIAYKIFNQSCILHCPPNYKSVNNTCVHCGGRCEKICDGINVDSIALAKQLRGCTHIKGSLEIQIRAGTNVVNVLEENLNMIEEISGYLKVVRSFSLVSLNFLKSLKRIKGEKLESQKYVFVVLDNQNLQELW--DWKNKTLKIHN--------GSLFFHFNPKLCIYKIEKLQEVA-MPHLPHFTDLEVAPNSNGDQIACNVTDLPVKITYVDSNY----ITLEWNQFEME--------DQRSLLAYTLYCTEAP-----SQNITLYDGRDA--------CGQDNW------------------------RVYDVQNQPSEKKIVQPLPNL------------------------------KPYTYYAFYVKT-----YTIASARTGAQSEIMYFRTNASMPSPPQNLQVISNSSDSLKISWLPPAHPNGDITHYIV-----SGKKHLNGD---LYSKDRDYCADPPTKTEAPQVIQPTLSPKSNDTCVCAENP--ERTL---SINEMEESARIKFEDELQNKVY----------------IRRKDPIRTKRHTAAHPFPN----NTESMSPSFRNNVIQNVTENGTDIWESFSFPVYG------KTDFFIDKLHHFTSYVINVQACRKKEGENDVESR-CSSTSMQTQRTLKKRGADRI---NKVHITNQSLDTVTVAWEPPQDPNGVIFTISIEYKALDNDNVNAKVYPECITSYRFTNDSTYSINLPTPGNYSLRVFATTSAGEGEYSPYIYVYINESSSNTVVIVSVILIIFLGVLLFGGWIYRKRQKEKENMRLIQSVNPEYVPSVYIPDEWEVPRKKIELIKELGQGSFGMVWEGVAHDIKGQPEVRCAIKTVNEHATNRERLEFLNEASVMKAFDTAHVVRLLGVVSQGQPTLVIMELMAHGDLKSYLRSHRPDIENY 1132
BLAST of insulin receptor-2 vs. nr
Match: gi|1080036711|ref|XP_018578755.1| (insulin-like receptor [Anoplophora glabripennis]) HSP 1 Score: 478.019 bits (1229), Expect = 1.026e-142 Identity = 374/1243 (30.09%), Postives = 574/1243 (46.18%), Query Frame = 0
Query: 34 VCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIV----SRAFFGNLEIEDGYESTLCPFECPGR---------------CPQDGREHGK-----MRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQ-DVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGN--QYVGEVKTTFKDYQGKCLRQCPHNTKEEEGTCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEG-KDHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTSHISDL-----SNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMS---SPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKF-KDSKFRYQLPVEGSYFVSVRAISQSGRGNWTDYIWLEQRSVDWFIVVPSLFAILAFAVLVCIGYLIWRQ----KQNKNAFSTQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLD-QGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGTEAF 1233
+C S+ + ++ L + LENC VIEG + +++ F+ E E L R FP + EITDYLL+YR L S+ +LFPNL+VIRG L +A I + +L++IGL SLT I G V I NP LC+VHTI+W+RIV ++F +L+ E+ CP CPG CP+ R G LCWN+ HCQKI + CT C+ Q C CLGGCS + T+C++ + C CP ++ F+Y RCI+KE+C ++ ++ + +K ++ C+ CP N K TCI C C VC G V +I ++L GCT IKG+L IQ+ +G VV LEE L+ + I G LKI R FSL+SL+F SL+ I+G K Q++++ +L+N+NL++L+ K+ ++ G F H+NP LC +IE+L A M H +D SNG++ C+ +L V T S F I L++ F+ + D R LL Y V+ + + N+T YDGRDA C +D W + + VAN +++ + N+ +P+TYY +V T Y GAQS+I Y + P+ P+++ ++ + +L ++WLPP +PNG I HY V + + S + P T T AP ++ SP +TC C+ P E+ + +I+ + ++ F D + N V+ + + R +R+ + + P + P ++ + V E D F VY T ++ L HF Y + V+AC + K DN + CS T + R K A+ I + H+ + I W PP +PNG+I V +K D+ AN CV + F DS +R G+Y + V A + +G G ++ YI+ +V ++ F L G +R+ K+N + NP Y P YI D+WE+ R + +G+G+F MV++G H + Q +++ AIK +E A + E ++FL EA +MK T HVV+L+GVVS P +V++E MA GDL+S+L S+RP E +
Sbjct: 65 ICKSVDVRNS-LDAFSKLENCEVIEGFLQILL----FDNVSESEFLKR-QFPLLTEITDYLLLYRVSGLRSIGQLFPNLSVIRGQSLFFSNAFVIFEMSSLQEIGLYSLTDITHGAVRIDKNPSLCFVHTIDWDRIVHDKSEKSFIKSLKPENE-----CPV-CPGNIDVKVNGDNNSATVACPKAPRTSGDSFEKDRHLCWNRRHCQKICPDNCTA----CNDRGQ----CCGPLCLGGCSNDDPDDCTVCKNFTVETEKKRQCTQSCPPNY------------------------FKYLDRRCITKEECISMPKPLEFHATNEIAYKIFKQSCILHCPPNYKSVNNTCIHCGGRCEKVCDGINVDSIALAKQLRGCTHIKGSLEIQIRAGSKVVNVLEENLNMIEEISGYLKIVRSFSLVSLNFLKSLKRIKGEKLESQKYAVVILDNQNLQELWD----------WKNRTLKIDNGSLFFHFNPKLCMYKIEKLQEVA-MPHLPHFTDHEVAPNSNGDQIACNVTDLPVKITYVESNF----ITLEWNQFEME--------DQRSLLAYTVYCIEAP-----SRNITLYDGRDA--------CSQDNWRVYD------------VANQPGEKKIVQPLPNL------------------------------------------KPYTYYAFYVKT-----YTIASARTGAQSEIKYFRTNASMPSPPQNLQVISNSSDSLKISWLPPANPNGNITHYIVSGKKHSNGDMYSKDRNYCKDPP--------TKTEAPQVIQPTPSPKSNDTCICAENP---ERSI--SINEMEEAARIKFEDELQNKVYIRRKDPIRT--KRQATA---YTFPNNTESLSPSFKNNVIQN---------VTENGTDIWESFSFPVYG------KTDFFIDKLHHFTFYVINVQAC-REKEGDNDMESRCSSTSMQTQRTLKKRGADRI---NKVHITNQSLDTVTIAWEPPEEPNGVIFTISVEYKRIDIDNAKANP-ECVTSKDFTNDSSYRIMKLFPGNYSLRVVATTSAGEGEYSPYIYFYINESSSNTIVIVSVTLIIFLGLFLFGGCFYRKHQKDKENMRLIQSVNPEYVPSVYIPDEWEVPRKKIDLIKELGQGSFGMVWEGIAHDIKGQPEVRCAIKTVNEHATNRERLEFLNEASVMKAFDTAHVVRLLGVVSQGQPTLVIMELMANGDLKSYLRSHRPDIENY 1130
BLAST of insulin receptor-2 vs. nr
Match: gi|751211784|ref|XP_011158641.1| (PREDICTED: insulin-like peptide receptor [Solenopsis invicta]) HSP 1 Score: 482.256 bits (1240), Expect = 2.332e-142 Identity = 370/1261 (29.34%), Postives = 609/1261 (48.30%), Query Frame = 0
Query: 12 ITVVVVVLLLVQALNIP--NTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNI-GNQYVGEVKTT----FKDYQGKCLRQCPHNTKEEEG----TCITCSD-DCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMN--TTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSP----SYESPMTSTTTTSAP--PLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSW---QVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHK--AKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAI----ITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRY---QLPVEGSYFVSVRAISQSGRGNWTD--YIWLEQRSV--DWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNA-----FSTQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQG--DIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
+ + + L A NI + +VC SI + + N++++ L+ C V+EG V + + ++ EP + A +FP + EITD+LL+YR + L ++ +LFPNL VIRGN L+ AL + +L++IGL SLT ILRG V + NP+LC+V TI+W+ I+++A G I+D S CP CP +CP + LCWN HCQ+I +C ED C+ Q C CLGGC+ + ++ ++CR+ V C+ CP+ +++ + RCI + +C + + Y E + +K + C+ +CP E E +C C C C A+V +I+ +KL GCT + G+L I++ GKN+V++LE+ L + I+GSL+I R F LISL+F +L VI G D ++SL++L+N+NL++L+ N + + I I G P F H+NP LC EIE+L A + T ++ SNG+K C+ ELE T + +P G ++++ F+ HDIR LLGY V+F + +N+T YDGRD AC D W + + +T+ A Q N +H+++ + I TQL+ P+T Y +V T Y GAQSKI Y P PR + + L ++W PP+ NG + HY +V + + + P +SP L ++T++C CS V ++ ++++ +S S F + + N V+ K R +RRRR D E+L+ QL EP++ Q E D V+ + ++ L+HF Y ++V+AC + A +++ +K CS + R A++I ++ L +G ++++ ++W P PNG+I Y + +K +++ +V C+ + F RY +LP G+Y + VRA S +G G +T+ Y +E+ +++IV+ S+ ++ ++ I Y+I ++K +N +T NP Y Y+ D+WE+ R + +G G+F MVY+G + +G +++ A+K +E+A E ++FL EA +MK T HVV+L+GVVS P +V++E M GDL+++L S+RP
Sbjct: 166 VLFIFAICNLAAANNIAIGPSRNKVCQSIDIRN-NVNEFSKLKGCQVVEGFVQISL-IDRAEPLD----YANFSFPELVEITDFLLLYRVNGLKTIGQLFPNLAVIRGNSLIMNYALMAFEMMHLQEIGLHSLTNILRGSVHFEKNPMLCFVDTIDWD-IIAKAGNGEHFIKDNKPSNGCPM-CPRKCPTR-QTKPDQNLCWNVQHCQRICDRKC--EDRACNSTGQ----CCHPFCLGGCTGPTANDCSVCRNV--VINGKECKDRCPR------------------------GKYKFMNRRCIEEWECRQMPKSMYKNEDEMIKQHPYKPFNDSCVIECPAGYMESEDHGNVSCQKCEGRQCLRECSAAKVMSIETAQKLRGCTHLTGSLEIEIRGGKNIVKELEDNLGMIEEIDGSLRIVRSFPLISLNFLKNLRVIRGNDSESKYSLSVLDNQNLQELWDWN-THKNITILAKTG----PARLFFHFNPKLCLHEIEKLRLKANLEEFTDHDVASNSNGDKIACNVTELETRVTWR-TPVG---AIIKWTAFK--------HHDIRSLLGYVVYFIEAP-----NQNITMYDGRD--------ACGGDGWRVEDVSADSTTLFA--------NQTQNSTHTDLQEHLHI-------------------LTQLK-------------PYTQYAYYVKT-----YTIATERSGAQSKITYFTTKPDAPGSPRALSTWSNSSNELVISWFPPVKKNGNLTHYRIVGRWEPDDQSFIDQRNYCDEPMPLLETKSPEEVVAEEEKKYFELEKEFSKTDSCLCSDREVTDQSMLEKEVS-----SSIAFENALHNQVYIK-----RAQSRRRRHTDS----------------EMLIAAQLAKEPTFKKVQNWESISDKMENGSVLVFERIIPSTNLTFVMRNLRHFTAYNIEVQACRELDASELNDTKSKNCSMKSMKTYRTLAMENADNIPPNTFT-LTKSGENNSLTIITLSWDEPPQPNGLIVTYQIEYK-RIDIQNIQATVVCITRRDFVKLGNRYTLKELPA-GNYSIKVRATSLAGNGAYTEVKYFSIEESDTLSEFWIVICSIIGVMTIVIIFFISYVI-KKKSMRNVPSMRLIATVNPEYVSTSYVPDEWEVPRKKIQLLRELGNGSFGMVYEGLAKDVVKGKPEVRCAVKTVNENATDRERIEFLNEASVMKAFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRP 1280
BLAST of insulin receptor-2 vs. nr
Match: gi|752507662|ref|NP_001291521.1| (insulin-like peptide receptor [Solenopsis invicta] >gi|326370574|gb|ADZ56366.1| insulin receptor-2 [Solenopsis invicta]) HSP 1 Score: 481.485 bits (1238), Expect = 5.680e-142 Identity = 370/1261 (29.34%), Postives = 609/1261 (48.30%), Query Frame = 0
Query: 12 ITVVVVVLLLVQALNIP--NTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNI-GNQYVGEVKTT----FKDYQGKCLRQCPHNTKEEEG----TCITCSD-DCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKDHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMN--TTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSP----SYESPMTSTTTTSAP--PLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSW---QVPEPEYDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACHK--AKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAI----ITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRY---QLPVEGSYFVSVRAISQSGRGNWTD--YIWLEQRSV--DWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNA-----FSTQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQG--DIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
+ + + L A NI + +VC SI + + N++++ L+ C V+EG V + + ++ EP + A +FP + EITD+LL+YR + L ++ +LFPNL VIRGN L+ AL + +L++IGL SLT ILRG V + NP+LC+V TI+W+ I+++A G I+D S CP CP +CP + LCWN HCQ+I +C ED C+ Q C CLGGC+ + ++ ++CR+ V C+ CP+ +++ + RCI + +C + + Y E + +K + C+ +CP E E +C C C C A+V +I+ +KL GCT + G+L I++ GKN+V++LE+ L + I+GSL+I R F LISL+F +L VI G D ++SL++L+N+NL++L+ N + + I I G P F H+NP LC EIE+L A + T ++ SNG+K C+ ELE T + +P G ++++ F+ HDIR LLGY V+F + +N+T YDGRD AC D W + + +T+ A Q N +H+++ + I TQL+ P+T Y +V T Y GAQSKI Y P PR + + L ++W PP+ NG + HY +V + + + P +SP L ++T++C CS V ++ ++++ +S S F + + N V+ K R +RRRR D E+L+ QL EP++ Q E D V+ + ++ L+HF Y ++V+AC + A +++ +K CS + R A++I ++ L +G ++++ ++W P PNG+I Y + +K +++ +V C+ + F RY +LP G+Y + VRA S +G G +T+ Y +E+ +++IV+ S+ ++ ++ I Y+I ++K +N +T NP Y Y+ D+WE+ R + +G G+F MVY+G + +G +++ A+K +E+A E ++FL EA +MK T HVV+L+GVVS P +V++E M GDL+++L S+RP
Sbjct: 166 VLFIFAICNLAAANNIAIGPSRNKVCQSIDIRN-NVNEFSKLKGCQVVEGFVQISL-IDRAEPLD----YANFSFPELVEITDFLLLYRVNGLKTIGQLFPNLAVIRGNSLIMNYALMAFEMMHLQEIGLHSLTNILRGSVHFEKNPMLCFVDTIDWD-IIAKAGNGEHFIKDNKPSNGCPM-CPRKCPTR-QTKPDQNLCWNVQHCQRICDRKC--EDRACNSTGQ----CCHPFCLGGCTGPTANDCSVCRNV--VINGKECKDRCPR------------------------GKYKFMNRRCIEEWECRQMPKSMYKNEDEMIKQHPYKPFNDSCVIECPAGYMESEDHGNVSCQKCEGRQCLRECSAAKVMSIETAQKLRGCTHLTGSLEIEIRGGKNIVKELEDNLGMIEEIDGSLRIVRSFPLISLNFLKNLRVIRGNDSESKYSLSVLDNQNLQELWDWN-THKNITILAKTG----PARLFFHFNPKLCLHEIEKLRLKANLEEFTDHDVASNSNGDKIACNVTELETRVTWR-TPVG---AIIKWTAFK--------HHDIRSLLGYVVYFIEAP-----NQNITMYDGRD--------ACGGDGWRVEDVSADSTTLFA--------NQTQNSTHTDLQEHLHI-------------------LTQLK-------------PYTQYAYYVKT-----YTIATERSGAQSKITYFTTKPDAPGSPRALSTWSNSSNELVISWFPPVKKNGNLTHYRIVGRWEPDDQSFIDQRNYCDEPMPLLETKSPEEVVAEEEKKYFELEKEFSKTDSCLCSDRVVTDQSMLEKEVS-----SSIAFENALHNQVYIK-----RAQSRRRRHTDS----------------EMLIAAQLAKEPTFKKVQNWESISDKMENGSVLVFERIIPSTNLTFVMRNLRHFTAYNIEVQACRELDASELNDTKSKNCSMKSMKTYRTLAMENADNIPPNTFT-LTKSGENNSLTIITLSWDEPPQPNGLIVTYQIEYK-RIDIQNIQATVVCITRRDFVKLGNRYTLKELPA-GNYSIKVRATSLAGNGAYTEVKYFSIEESDTLSEFWIVICSIIGVMTIVIIFFISYVI-KKKSMRNVPSMRLIATVNPEYVSTSYVPDEWEVPRKKIQLLRELGNGSFGMVYEGLAKDVVKGKPEVRCAVKTVNENATDRERIEFLNEASVMKAFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRP 1280
BLAST of insulin receptor-2 vs. nr
Match: gi|1059867402|ref|XP_017788387.1| (PREDICTED: LOW QUALITY PROTEIN: insulin-like peptide receptor [Habropoda laboriosa]) HSP 1 Score: 478.789 bits (1231), Expect = 1.844e-141 Identity = 374/1233 (30.33%), Postives = 591/1233 (47.93%), Query Frame = 0
Query: 34 VCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDG-CRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGN-QYVGEVKTT-FKDYQGKCLRQCPHNTKEEEG----TCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKD-HGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGM--NTTSHISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSP-------SYESPMTSTTTTSAPPLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYSTRVHPEATH-LLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAI----ITWLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKF---KDSKFRYQLPVEGSYFVSVRAISQSGRGNWTD--YIWLEQR-SVDWFIVVPSLFAILAFAVLVCIGYLIWRQK-----QNKNAFSTQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQG--DIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRPGT 1230
VC SI + ++ ++ + L+ C VIEG + +++ ++ EP E A ++FP ++EIT YLL YR L S+ RLFPNLTVIRG+ L AL + + NL++IGL+SLTTI+RG V NP LCYV TI+W+ ++ +A G I CP C RCP+ + + LCWN+ HCQ+I + C E+ C D G C +CLG C +G C C+DV T D CR CP + ++ +RCI++ C + + V VK +K + G C+ +CP +EE +C C C C GA+V +I +KL GCT I G+L IQ+ GKN+V++LE +LS + I+G LKI R F LISL+F +L VI G D + E+SL +L+N+NL++L+ N + IQI G PG F H NP LC +IE L G+ T ++ SNG+K C+ EL+ + S + +++E F + HD R LLGY V+F + +N+T YDGRD AC D W +++ P N++ + N +SQ ++P+T Y +V T + T+ GAQS + Y + P+ PR + + + L ++WLPPL NG + +Y++V L+ P+ + + P + + +P ET TC+C+ + +E S + F D + N V+ K R R+R + + K S P + D++ E SY V R P H ++ L HFG Y ++V+AC +AK +N + CS R P A++I ++ ++ +G ++++ + W P+ PNG+I Y + +K +++ + ++ C+ Q F ++S F +LP G+Y V VRA S +G G +T Y ++E+R +V+ F +V SL + A+ + + + ++K N+ F+T NP+Y Y+ D+WE+ R + +G G+F +VY+G + +G +++ A+K ++DA E +FL EA +MK HV++L+GVVS P +V++E M GDL+ FL S+RP T
Sbjct: 213 VCQSIDIRNS-VTFFSRLKGCRVIEGYLQILL-IDNAEPQE----YANISFPELKEITGYLLFYRVKGLRSIGRLFPNLTVIRGHSLFINYALVVFEMMNLQEIGLRSLTTIVRGSVRFDKNPALCYVDTIDWD-LIGKAGKGEHVIAGNNPRNGCPV-CEKRCPKRLTKPDEY-LCWNQQHCQRICKQGC--ENNAC--DDAG--NCCHPSCLGTC---TGPTIADCVVCKDVITMDNECRDRCP------------------------NGTVEFMDHRCINESRCRQMEKPRGVYNVKNYPYKLFNGSCVIECPPGYMDEESNGTVSCKKCEGPCQKECSGAKVDSIASAQKLRGCTHITGSLEIQIRGGKNIVKELEVSLSTIEEIDGYLKIVRSFPLISLNFLKNLRVIRGNDTNNSEYSLHVLDNQNLQELWDWNMH-KNIQILSQNG----PGKIFFHLNPKLCLYKIELLREKVGLLPFTDYDVAPNSNGDKVACNVTELKTRVGTKSSVGAV----IEWEPF--------IHHDARSLLGYVVYFIEAP-----NKNVTMYDGRD--------ACGGDGWKVDD---------VPAATNMTSMKEKNVQSHYLSQ---------------------------------------LKPYTQYAYYVKTHTI----ATERF-GAQSNLTYFRTMPDAPSLPRSLSTWSNSSSELILSWLPPLHKNGNLSNYKIVGRLERDDPNFIDQRNYCDEPILLPDTKAIALAEEERKRIEEEKELMAP-ETVTCECTDKETDQSLREKEASSAIA------FEDAVHNQVYVK-----RKTRRKREASEGSYGSSRKTKASERDQP---LEDKI---------------ENGSY--VQFERWIPSTNHSFVMKNLSHFGAYNIEVQAC-RAKENNNDTFQKCSTKSMRTYRTLPMKSADNIPPNTF-NMTISGKNNSLPMVKLQWGEPAHPNGLIVTYQIEYK-RVDIPDYKATLVCITRQNFTKARNSYFLKELP-SGNYSVRVRATSLAGNGEYTQEKYFYIEERNTVNVFWIVFSLVLCVILAIFGFVSFYVVKRKLMKGVPNRTLFATVNPDYVSTPYVLDEWEVPRENIEMLRPLGNGSFGLVYEGIAKDIVKGKPEVRCAVKTVNKDANARERNEFLNEASMMKSFDAHHVIRLLGVVSRGQPTLVIMELMVNGDLKEFLRSHRPTT 1284
BLAST of insulin receptor-2 vs. nr
Match: gi|307185461|gb|EFN71461.1| (Insulin-like receptor [Camponotus floridanus]) HSP 1 Score: 474.552 bits (1220), Expect = 1.037e-140 Identity = 369/1238 (29.81%), Postives = 594/1238 (47.98%), Query Frame = 0
Query: 34 VCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGN--QYVGEVKT-TFKDYQGKCLRQCPHNTKE-----EEGTCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKD-HGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGM-NTTSH-ISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTE----DCVMNSPSYESPMT------STTTTSAPPLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPE--YDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACH-KAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIIT---WLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRY---QLPVEGSYFVSVRAISQSGRGNWTD--YIWLEQR---SVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNAFS-----TQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHL--DQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
VC SI + ++ + ++ L C V+EG V +++ E A L+FP++ EIT YL++YR L S+ RLFPNLTVIRG+ L AL + +L++IGL SLT ILRG V + NP LCYV TI+W+ I+++A G I + CP C CP + + LCWN+ HCQ++ +C D C +++ + C+ +CLGGC+ S +N T+CR +V C+ CP + +++ + RC+S++ C I + + VK +K + G C+ +CP E + TC C C C GA V +I +KL GCT I G+L IQ+ GKN+V++LE+ LS + I+G LK+ R F LISL+F +L VI G ++SL +L+N+NL++L+ ++ + I G +P + F H+NP LC +I+ L A + N T H ++ SNG+K C+ EL+ T + S I +++E F HD R LLGY V+F + A +Q N+T YDGRD AC D W + + A+ ++ H++ Q + IL++ ++P+T Y +V T + E GAQSK+MY P+ PR + I + + L ++W PPL NG + HY +V + P+ + D M+ P + PM+ L+ SP ET +C C+ ++ + ++ +S S F + + N V+ K N RRRR V E+L+ +L + ++ + E D + V+ + +++ L+HF Y ++V+AC + + D CS + R A++I ++ + + G++S I W P PNG+I Y + +K +++ ++V C+ + F + Y LP G+Y V VRA S +G G +T+ Y ++++ S W L I+ ++LV + I+R++ +NA S T NP Y Y+ D+WE+ R V +G G+F MVY+G + DQ +++ A+K +E+A E ++FL EA +MK T HVV+L+GVVS P +V++E M GDL+++L S+RP
Sbjct: 10 VCQSIDIRNS-VDQFLRLNGCRVVEGFVQILLIDRA-----EQSAYANLSFPDLVEITGYLILYRVSGLRSIGRLFPNLTVIRGHSLFINYALVAFEMMHLQEIGLHSLTNILRGSVRFEKNPTLCYVDTIDWD-IIAKAGKGEHVISGNKITNGCPV-CDKSCPSRQTKPDET-LCWNRQHCQRVCDHKCG--DNACDINTG---KCCNSSCLGGCTGLSNANCTVCR---NVMVGTECKDSCP------------------------NGTYEFMNRRCVSEKMCREIRKPREALDSVKYHPYKPFNGTCVIECPAGYMESTDNDQNLTCRKCEGSCLKECTGANVDSIASAQKLRGCTHIAGSLEIQIRGGKNIVKELEDNLSTIEEIDGYLKVIRSFPLISLNFLKNLRVIRGNTLENNKYSLAVLDNQNLQELWDW-STHPNLTILSSAG---SPKV-FFHFNPKLCMYKIDMLREKAKLDNFTEHDVAINSNGDKVACNVTELKTKITKKTSRGAI----IEWEPFS--------HHDYRSLLGYVVYFIE---APYQ--NVTMYDGRD--------ACGGDGWRVEDVS----------------AESTSQQHNDTQQP-----------------------------YLAHILTL-LKPYTQYAYYVKTYTIATEES-----GAQSKVMYFTTLPDAPSSPRALSIWSNSSSELVMSWFPPLHKNGNLTHYRIVGRWEPDDPNFIDQRNYCDEPMSLPEKKLPMSVIAEEERKRAEEEKELVKSP-ETTSCGCADRETTDQSMREKEVS-----SSIAFENALHNQVYVKRMNA-----RRRRDVKS----------------EMLITAELAKDSNYNQQDKEGINDKLDNGTYTVFERLIPSTNLSVVMKNLRHFAAYNIEVQACRERVENEDKSKKNNCSTKSMKTYRTLAMESADNIPPNTFKFSISGGNNSLTIVTLYWEEPPQPNGLIVTYQIEYK-RVDIKNIKSTVVCITRRDFTKAGNSYVLKDLPA-GNYSVKVRATSLAGYGAYTEVKYFYIKEYGMLSTFWIFFWLILTLIMLSSILVI--FYIFRRRSARNASSVKIIATVNPEYVSTGYVPDEWEVARKKVQLIRELGNGSFGMVYEGLAKDVVKDQPEVRCAVKTVNENATDRERIEFLNEASVMKAFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRP 1094
BLAST of insulin receptor-2 vs. nr
Match: gi|752869275|ref|XP_011251746.1| (PREDICTED: insulin-like receptor [Camponotus floridanus] >gi|752869277|ref|XP_011251747.1| PREDICTED: insulin-like receptor [Camponotus floridanus]) HSP 1 Score: 476.478 bits (1225), Expect = 2.776e-140 Identity = 373/1273 (29.30%), Postives = 607/1273 (47.68%), Query Frame = 0
Query: 3 LQNGSEHQSITVVVVVLLLVQALNIP----NTHGEVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGN--QYVGEVKT-TFKDYQGKCLRQCPHNTKEEEG-----TCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGKD-HGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGM-NTTSH-ISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTE----DCVMNSPSYESPMT------STTTTSAPPLMSSPNETETCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPE--YDPETRSYFRVYSTRVHPEATHLLLNPLQHFGDYQVKVRACH-KAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIIT---WLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRY---QLPVEGSYFVSVRAISQSGRGNWTD--YIWLEQR---SVDWFIVVPSLFAILAFAVLVCIGYLIWRQKQNKNAFS-----TQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHL--DQGDIQVAIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
+E + + +V ++ L + ++ N+ VC SI + ++ + ++ L C V+EG V +++ E A L+FP++ EIT YL++YR L S+ RLFPNLTVIRG+ L AL + +L++IGL SLT ILRG V + NP LCYV TI+W+ I+++A G I + CP C CP + + LCWN+ HCQ++ +C D C +++ + C+ +CLGGC+ S +N T+CR +V C+ CP + +++ + RC+S++ C I + + VK +K + G C+ +CP E TC C C C GA V +I +KL GCT I G+L IQ+ GKN+V++LE+ LS + I+G LK+ R F LISL+F +L VI G ++SL +L+N+NL++L+ ++ + I G +P + F H+NP LC +I+ L A + N T H ++ SNG+K C+ EL+ T + S I +++E F HD R LLGY V+F + A +Q N+T YDGRD AC D W + + A+ ++ H++ Q + IL++ ++P+T Y +V T + E GAQSK+MY P+ PR + I + + L ++W PPL NG + HY +V + P+ + D M+ P + PM+ L+ SP ET +C C+ ++ + ++ +S S F + + N V+ K N RRRR V E+L+ +L + ++ + E D + V+ + +++ L+HF Y ++V+AC + + D CS + R A++I ++ + + G++S I W P PNG+I Y + +K +++ ++V C+ + F + Y LP G+Y V VRA S +G G +T+ Y ++++ S W L I+ ++LV + I+R++ +NA S T NP Y Y+ D+WE+ R V +G G+F MVY+G + DQ +++ A+K +E+A E ++FL EA +MK T HVV+L+GVVS P +V++E M GDL+++L S+RP
Sbjct: 155 FHKSTEWRRLLWIVFLVFLASSPDLAAAQQNSTDGVCQSIDIRNS-VDQFLRLNGCRVVEGFVQILLIDRA-----EQSAYANLSFPDLVEITGYLILYRVSGLRSIGRLFPNLTVIRGHSLFINYALVAFEMMHLQEIGLHSLTNILRGSVRFEKNPTLCYVDTIDWD-IIAKAGKGEHVISGNKITNGCPV-CDKSCPSRQTKPDET-LCWNRQHCQRVCDHKCG--DNACDINTG---KCCNSSCLGGCTGLSNANCTVCR---NVMVGTECKDSCP------------------------NGTYEFMNRRCVSEKMCREIRKPREALDSVKYHPYKPFNGTCVIECPAGYMESTDNDQNLTCRKCEGSCLKECTGANVDSIASAQKLRGCTHIAGSLEIQIRGGKNIVKELEDNLSTIEEIDGYLKVIRSFPLISLNFLKNLRVIRGNTLENNKYSLAVLDNQNLQELWDW-STHPNLTILSSAG---SPKV-FFHFNPKLCMYKIDMLREKAKLDNFTEHDVAINSNGDKVACNVTELKTKITKKTSRGAI----IEWEPFS--------HHDYRSLLGYVVYFIE---APYQ--NVTMYDGRD--------ACGGDGWRVEDVS----------------AESTSQQHNDTQQP-----------------------------YLAHILTL-LKPYTQYAYYVKTYTIATEES-----GAQSKVMYFTTLPDAPSSPRALSIWSNSSSELVMSWFPPLHKNGNLTHYRIVGRWEPDDPNFIDQRNYCDEPMSLPEKKLPMSVIAEEERKRAEEEKELVKSP-ETTSCGCADRETTDQSMREKEVS-----SSIAFENALHNQVYVKRMNA-----RRRRDVKS----------------EMLITAELAKDSNYNQQDKEGINDKLDNGTYTVFERLIPSTNLSVVMKNLRHFAAYNIEVQACRERVENEDKSKKNNCSTKSMKTYRTLAMESADNIPPNTFKFSISGGNNSLTIVTLYWEEPPQPNGLIVTYQIEYK-RVDIKNIKSTVVCITRRDFTKAGNSYVLKDLPA-GNYSVKVRATSLAGYGAYTEVKYFYIKEYGMLSTFWIFFWLILTLIMLSSILVI--FYIFRRRSARNASSVKIIATVNPEYVSTGYVPDEWEVARKKVQLIRELGNGSFGMVYEGLAKDVVKDQPEVRCAVKTVNENATDRERIEFLNEASVMKAFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRP 1274
BLAST of insulin receptor-2 vs. nr
Match: gi|1000761285|ref|XP_015603667.1| (PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761287|ref|XP_015603669.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761289|ref|XP_015603670.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761291|ref|XP_015603671.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761293|ref|XP_015603672.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761295|ref|XP_015603673.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761297|ref|XP_015603674.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761299|ref|XP_015603675.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus] >gi|1000761301|ref|XP_015603676.1| PREDICTED: insulin-like receptor isoform X1 [Cephus cinctus]) HSP 1 Score: 468.389 bits (1204), Expect = 1.263e-137 Identity = 370/1238 (29.89%), Postives = 585/1238 (47.25%), Query Frame = 0
Query: 33 EVCGSITLNSTNLSDYIHLENCTVIEGNVGVMIGLETFEPPEEVEVLARLTFPNIQEITDYLLIYRADKLTSLSRLFPNLTVIRGNELLGESALTILQNENLKDIGLKSLTTILRGGVTIKGNPLLCYVHTINWERIVSRAFFGNLEIEDGYESTLCPFECPGRCPQDGREHGKMRLCWNKNHCQKIQLEQCTTEDAHCHLDSQGEVEVCSRNCLGGCSRHSGSNHTLCRSCQDVRTPDGCRSECPQDFLLVITANLIMFPLFVIFCQCQHSVFQYKSYRCISKEDCPNIGNQYVGEVKTTFKDY------QGKCLRQCPHNTKEEE----GTCITCSDDCPTVCGGAEVTTIQDLEKLNGCTIIKGTLAIQL-SGKNVVQKLEEALSKVRIIEGSLKISRVFSLISLDFFTSLEVIEGK--DHGQEFSLTLLNNENLRKLFPTNASGQGIQIHKHEGRRVAPGLGFIHYNPHLCRTEIERLLSSAGMNTTS--HISDLSNGNKGICDPLELEVNATAQISPFGIPEIMLQFEGFQKKIQEQDLKHDIRGLLGYQVHFKKISLATFQAENLTRYDGRDACLESCSSACPKDIWHINEFQPVESTILAPTVANVSEAQRVNESHSNVSQSSKIELSPKIILQNSSLINSLGNRTQLQLTWPDEILSIKVEPFTYYGVFVTTLLLREYEGTKTIRGAQSKIMYIQAAVYFPTEPRDVHIVGVNHTALNVTWLPPLSPNGEIDHYEVVVELKTKQPHVSTEDCVMNSPSYESPMTSTTTTSAPPLMSSPNETE--------TCDCSGCPVQEEQLVQETISLVGTISQNMFNDLIMNSVFRKTGNTSRNLNRRRRSVDQRESVPTKETTSHPPVPEVLVYDQLGSEPSWQVPEPEYDPETRSYFRVYST--RVHPEAT-HLLLNPLQHFGDYQVKVRACHKAKLVDNILTKWCSPTVSERPRVPPKPMANDILSSSLRHLPTNGSSSAIIT---WLPPSDPNGIIERYIVSHKAKMEDDESANSVSCVFPQKFKDSKFRY---QLPVEGSYFVSVRAISQSGRGNWTD--YIWLEQRSVDW-FIVVPSLFAILAFAVLVCIGYLIWRQKQNKNA-----FSTQNPNYCPMEYIADDWEINRNLVHAGDHIGKGAFAMVYKGTYHHLDQGDIQV--AIKMPHEDAGHLECMQFLQEAHLMKEIKTPHVVQLIGVVSVNLPYMVLLEYMALGDLRSFLSSYRP 1228
EVC S+ + ++ +S++ LE C V+EG V +++ + +++ A LTFP++ EIT YL++YR + L S+ +LFPNLTVIRG+ L AL + + +L++IGL SLT ILRG V + NP LCYV TI+W+ I ++A G I CP C CP + + LCWNK HCQKI +C D C DS C +CLGGC+ + N T+CR + V + C CP +++ + RCI + +C + E T K+Y + C+ +CP EEE +C C C C GA V +I +KL GCT I G+L IQ+ GKN+V++ E++LS + I+G LKI R F LISL+F L +I+G D+G+ ++L +L+N+NL++L+ + + IQI + APG F H+NP LC +IE+L A + S ++ SNG+K C+ ++ T + S +++++ F+ HD R LLGY V+F + N+T YDGRD AC D W +++ ES S S+V LG + IL+ +++P+T Y +V T Y GAQS + Y P+ PR + + L ++W PPL NG + HY +V + P + + P S + + +E E CDC+ V ++ + ++ +S S F D + N V+ K N+ RRRR V S K ++ PE + DP + +Y+T R+ P ++ L+HF Y ++V+AC + + D++ CS R P A++I +++ + G++S + W P PNG+I Y + +K +++ +V C+ + F + Y LP G+Y + VRA S +G G +T+ Y ++E+ S F ++ +L A+LVC + + ++K +N +T NP Y Y+AD+WE+ R + +G G+F MVY+G + +G +V A+K +E+A E ++FL EA +MK T HVV+L+GVVS P +V++E M GDL+++L S+RP
Sbjct: 128 EVCQSVDIRNS-VSEFSRLEGCRVVEGFVQILL----IDRADDL-AYANLTFPDLVEITGYLVLYRVNGLKSVGKLFPNLTVIRGHSLFINYALVMFEMMHLQEIGLHSLTDILRGSVRFEKNPALCYVDTIDWDNI-AKAGKGEHVISGNKPKNGCPV-CEKNCPPRLTKPDET-LCWNKQHCQKICDSKCG--DYACS-DSG---TCCHPSCLGGCTGLTAQNCTVCR--EMVVDVNQCVKRCPI------------------------GTYEFMNRRCIQENECRTMPKP--KEALGTVKNYPYKLFNESSCVIECPAGYMEEEVNGKPSCKKCDGSCLKECAGASVDSIASAQKLRGCTHITGSLEIQIRGGKNIVKEFEDSLSMIEEIDGYLKIVRSFPLISLNFLKKLRLIKGNQLDNGK-YTLAVLDNQNLQELWDWDTHPK-IQIRSNG----APGKVFFHFNPKLCLHKIEKLREVANLAEFSPLEVALNSNGDKVACNVTDIITRVTKKTSEAA----LIEWQAFK--------HHDPRSLLGYVVYFIEAP-----NRNVTMYDGRD--------ACGGDGWKVDDVGATES------------------SDSSV---------------------PLGEEDSNHTEYLTHILT-QLQPYTQYAYYVKT-----YTIATERSGAQSNVSYFTTFPDAPSAPRALSTWSNASSELVMSWFPPLHKNGNLTHYRIVGRWEPDDPSFLAQRNYCDEPLLLPEKKSLAAMAEEERKKAESEMERARTPERTACDCAD-RVPDQSIREKEVS-----SSIAFEDALHNKVYVKKVNS-----RRRRDVSAMLSAVRKNPDTYYSYPE------------------DKDPNDKLEDGIYTTFERLVPSTNLSFVMRNLRHFAAYNIEVQACRERTVNDSLNN--CSTKSMRTYRTLPLESADNIPANTFKLSTIGGNNSLAMVRLQWEEPVKPNGLIVTYQIEYK-RVDIQNIKATVVCITRRDFVNGGKSYLLKDLP-PGNYSIKVRATSLAGNGAYTEVKYFYIEEYSTSGTFWILFWCILVLVLAILVCSVFYVCKKKNKRNVPNIRLIATVNPEYASTAYVADEWEVPREKIQLIRELGNGSFGMVYEGLAKDVVKGKPEVPCAVKTVNENATDRERIEFLNEASVMKAFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRP 1213 The following BLAST results are available for this feature:
BLAST of insulin receptor-2 vs. L. salmonis genes
Analysis Date: 2018-04-19 (T. kinsejongensis vs L. Salmonis peptides) Total hits: 4
BLAST of insulin receptor-2 vs. SwissProt
Analysis Date: 2018-04-19 (T. kingejongensis peptided Blastp vs. SwissProt) Total hits: 25
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BLAST of insulin receptor-2 vs. nr
Analysis Date: 2018-05-15 (T. kingsejongensis proteins Blastp vs. NR) Total hits: 25
Pagesback to topAlignments
The following features are aligned
Analyses
This gene is derived from or has results from the following analyses
Properties
Relationships
The following mRNA feature(s) are a part of this gene:
Sequences
The following sequences are available for this feature:
gene from alignment at scaffold383_size189472:71617..77266+ Legend: mRNA Hold the cursor over a type above to highlight its positions in the sequence below.>maker-scaffold383_size189472-snap-gene-0.28 ID=maker-scaffold383_size189472-snap-gene-0.28|Name=insulin receptor-2|organism=Tigriopus kingsejongensis|type=gene|length=5650bp|location=Sequence derived from alignment at scaffold383_size189472:71617..77266+ (Tigriopus kingsejongensis)back to top Synonyms
The feature 'insulin receptor-2' has the following synonyms
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