BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:NPC1 "Uncharacterized protein" species:9615 "Canis lupus familiaris" [GO:0005576 "extracellular region" evidence=IEA] [GO:0005635 "nuclear envelope" evidence=IEA] [GO:0005765 "lysosomal membrane" evidence=IEA] [GO:0005768 "endosome" evidence=IEA] [GO:0005783 "endoplasmic reticulum" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IEA] [GO:0006486 "protein glycosylation" evidence=IEA] [GO:0006897 "endocytosis" evidence=IEA] [GO:0006914 "autophagy" evidence=IEA] [GO:0007628 "adult walking behavior" evidence=IEA] [GO:0008158 "hedgehog receptor activity" evidence=IEA] [GO:0015485 "cholesterol binding" evidence=IEA] [GO:0016242 "negative regulation of macroautophagy" evidence=IEA] [GO:0031982 "vesicle" evidence=IEA] [GO:0033344 "cholesterol efflux" evidence=IEA] [GO:0042493 "response to drug" evidence=IEA] [GO:0045121 "membrane raft" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IEA] [GO:0071383 "cellular response to steroid hormone stimulus" evidence=IEA] [GO:0071404 "cellular response to low-density lipoprotein particle stimulus" evidence=IEA] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0005794 GO:GO:0048471 GO:GO:0007165 GO:GO:0005576 GO:GO:0005887 GO:GO:0005635 GO:GO:0006914 GO:GO:0045121 GO:GO:0042493 GO:GO:0005768 GO:GO:0006486 GO:GO:0006897 GO:GO:0005764 GO:GO:0015485 GO:GO:0033344 GO:GO:0007628 GO:GO:0031982 GO:GO:0008158 GO:GO:0071404 GO:GO:0071383 GO:GO:0016242 GeneTree:ENSGT00680000099777 OrthoDB:EOG7QRQT0 OMA:YEYTPFL TreeFam:TF300416 TIGRFAMs:TIGR00917 EMBL:AAEX03005455 Ensembl:ENSCAFT00000028892 Uniprot:F1PB50)

HSP 1 Score: 127.487 bits (319), Expect = 1.242e-30
Identity = 82/272 (30.15%), Postives = 127/272 (46.69%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPH-FESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVS-VKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            CV  G CG    +  G   +  C   GPP  +      LM++ CP  F   +S  +CC  +Q+R LK   +      S CP+C YN+  +FC+ TC P+QS+FLNV+  + +      +     K LQYY    F N++YN C+DV  PS +   +G +CG     C     + YM    +  +PF I   +SD P    H  +  +  T  CD P    + PCSC +C + C      +   +   + I G+D + ++M + +  F + F 
Sbjct:   26 CVWYGECG----IASGD-KRYNCQYSGPPKPLPKDGYDLMQELCPGLFFDNVS--VCCDVQQLRTLKDSLQLPLQFLSRCPSCFYNLMNLFCELTCSPQQSQFLNVTETEDYVDPVTNQTKTNVKELQYYVGESFANAMYNACRDVEAPSSNDKALGLLCGKEAEACNATNWIEYMFNKDNGQAPFTIIPIFSDLP---AHGMKPMNNATKGCDEPVDEVTAPCSCQDCSVVCGPKP--QPPPAPAPWRILGLDAMYVIMWITYMAFLLMFF 285          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:NPC1 "Niemann-Pick type C1 disease protein" species:9685 "Felis catus" [GO:0005635 "nuclear envelope" evidence=ISS] [GO:0005783 "endoplasmic reticulum" evidence=ISS] [GO:0005887 "integral component of plasma membrane" evidence=ISS] [GO:0007041 "lysosomal transport" evidence=ISS] [GO:0008206 "bile acid metabolic process" evidence=ISS] [GO:0042632 "cholesterol homeostasis" evidence=ISS] [GO:0048471 "perinuclear region of cytoplasm" evidence=ISS] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0048471 GO:GO:0007165 GO:GO:0005887 GO:GO:0005635 GO:GO:0008206 GO:GO:0042632 GO:GO:0007041 GO:GO:0030301 GO:GO:0008158 KO:K12385 CTD:4864 HOVERGEN:HBG003913 TIGRFAMs:TIGR00917 EMBL:AF258783 RefSeq:NP_001009829.2 ProteinModelPortal:Q9N0Q0 GeneID:493693 KEGG:fca:493693 Uniprot:Q9N0Q0)

HSP 1 Score: 122.479 bits (306), Expect = 6.410e-29
Identity = 78/271 (28.78%), Postives = 126/271 (46.49%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            C+  G CG    +  G   +  C   GPP  +      L+++ CP F  + + ++CC  +Q++ LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K LQYY    F N++YN C+DV  PS +   +G +CG     C     + YM +  +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C      +       + I G+D + ++M + +  F + F 
Sbjct:   25 CIWYGECG----IASGD-KRYNCKYSGPPKPLPKDGYDLVQELCPGFFFD-NVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLVNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYIGESFANAMYNACRDVEAPSSNDKALGLLCGKDAEACNATNWIEYMFSKDNGQAPFTITPIFSDLP---THGMEPMNNATKGCDESVDEVTGPCSCQDCSIVCGPKP--QPPPPPVPWRILGLDAMYVIMWITYMAFLLVFF 284          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:Q8MKD8 "Niemann-Pick C1" species:9685 "Felis catus" [GO:0005635 "nuclear envelope" evidence=ISS] [GO:0005783 "endoplasmic reticulum" evidence=ISS] [GO:0005887 "integral component of plasma membrane" evidence=ISS] [GO:0007041 "lysosomal transport" evidence=ISS] [GO:0008206 "bile acid metabolic process" evidence=ISS] [GO:0042632 "cholesterol homeostasis" evidence=ISS] [GO:0048471 "perinuclear region of cytoplasm" evidence=ISS] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0048471 GO:GO:0007165 GO:GO:0005887 GO:GO:0005635 GO:GO:0008206 GO:GO:0042632 GO:GO:0007041 GO:GO:0030301 GO:GO:0008158 HOVERGEN:HBG003913 TIGRFAMs:TIGR00917 EMBL:AF503634 ProteinModelPortal:Q8MKD8 Uniprot:Q8MKD8)

HSP 1 Score: 122.479 bits (306), Expect = 6.714e-29
Identity = 78/271 (28.78%), Postives = 126/271 (46.49%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            C+  G CG    +  G   +  C   GPP  +      L+++ CP F  + + ++CC  +Q++ LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K LQYY    F N++YN C+DV  PS +   +G +CG     C     + YM +  +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C      +       + I G+D + ++M + +  F + F 
Sbjct:   25 CIWYGECG----IASGD-KRYNCKYSGPPKPLPKDGYDLVQELCPGFFFD-NVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLVNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYIGESFANAMYNACRDVEAPSSNDKALGLLCGKDAEACNATNWIEYMFSKDNGQAPFTITPIFSDLP---THGMEPMNNATKGCDESVDEVTGPCSCQDCSIVCGPKP--QPPPPPVPWRILGLDAMYVIMWITYMAFLLVFF 284          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:NPC1 "Niemann-Pick C1 protein" species:9606 "Homo sapiens" [GO:0004872 "receptor activity" evidence=TAS] [GO:0004888 "transmembrane signaling receptor activity" evidence=TAS] [GO:0005515 "protein binding" evidence=IPI] [GO:0005576 "extracellular region" evidence=ISS] [GO:0005635 "nuclear envelope" evidence=IDA] [GO:0005764 "lysosome" evidence=ISS] [GO:0005765 "lysosomal membrane" evidence=IDA] [GO:0005783 "endoplasmic reticulum" evidence=IDA] [GO:0005794 "Golgi apparatus" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IDA] [GO:0006486 "protein glycosylation" evidence=IDA] [GO:0006897 "endocytosis" evidence=IEA] [GO:0006914 "autophagy" evidence=IGI] [GO:0007041 "lysosomal transport" evidence=ISS] [GO:0007165 "signal transduction" evidence=TAS] [GO:0007628 "adult walking behavior" evidence=IEA] [GO:0008158 "hedgehog receptor activity" evidence=IEA] [GO:0008203 "cholesterol metabolic process" evidence=IEA] [GO:0008206 "bile acid metabolic process" evidence=ISS] [GO:0015248 "sterol transporter activity" evidence=TAS] [GO:0015485 "cholesterol binding" evidence=IDA] [GO:0016021 "integral component of membrane" evidence=TAS] [GO:0016242 "negative regulation of macroautophagy" evidence=IEA] [GO:0030301 "cholesterol transport" evidence=IDA] [GO:0031902 "late endosome membrane" evidence=IEA] [GO:0033344 "cholesterol efflux" evidence=IDA] [GO:0042493 "response to drug" evidence=IEA] [GO:0042632 "cholesterol homeostasis" evidence=ISS;IDA] [GO:0045121 "membrane raft" evidence=IEA] [GO:0046686 "response to cadmium ion" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IDA] [GO:0060548 "negative regulation of cell death" evidence=IEA] [GO:0070062 "extracellular vesicular exosome" evidence=IDA] [GO:0071383 "cellular response to steroid hormone stimulus" evidence=IEA] [GO:0071404 "cellular response to low-density lipoprotein particle stimulus" evidence=IEA] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0005794 GO:GO:0046686 GO:GO:0070062 GO:GO:0048471 GO:GO:0005887 GO:GO:0005635 GO:GO:0006914 GO:GO:0045121 GO:GO:0031902 GO:GO:0005765 GO:GO:0042493 GO:GO:0008206 GO:GO:0006486 GO:GO:0008203 GO:GO:0006897 GO:GO:0015485 GO:GO:0033344 GO:GO:0042632 GO:GO:0015248 GO:GO:0007628 GO:GO:0004888 GO:GO:0060548 GO:GO:0007041 GO:GO:0008158 GO:GO:0071404 GO:GO:0071383 GO:GO:0016242 UniGene:Hs.464779 eggNOG:NOG149152 KO:K12385 OrthoDB:EOG7QRQT0 EMBL:AF002020 EMBL:AF157379 EMBL:AF157365 EMBL:AF157366 EMBL:AF157367 EMBL:AF157368 EMBL:AF157369 EMBL:AF157370 EMBL:AF157371 EMBL:AF157372 EMBL:AF157373 EMBL:AF157374 EMBL:AF157375 EMBL:AF157376 EMBL:AF157377 EMBL:AF157378 EMBL:AF338230 EMBL:AH009108 EMBL:BC063302 RefSeq:NP_000262.2 UniGene:Hs.715623 PDB:3GKH PDB:3GKI PDB:3GKJ PDBsum:3GKH PDBsum:3GKI PDBsum:3GKJ ProteinModelPortal:O15118 SMR:O15118 BioGrid:110925 IntAct:O15118 STRING:9606.ENSP00000269228 ChEMBL:CHEMBL1293277 TCDB:2.A.6.6.1 PhosphoSite:O15118 PaxDb:O15118 PeptideAtlas:O15118 PRIDE:O15118 Ensembl:ENST00000269228 GeneID:4864 KEGG:hsa:4864 UCSC:uc002kum.4 CTD:4864 GeneCards:GC18M021111 H-InvDB:HIX0039703 HGNC:HGNC:7897 HPA:HPA026618 MIM:257220 MIM:607623 neXtProt:NX_O15118 Orphanet:216986 Orphanet:216981 Orphanet:216978 Orphanet:216975 Orphanet:216972 PharmGKB:PA31698 HOVERGEN:HBG003913 InParanoid:O15118 OMA:YEYTPFL PhylomeDB:O15118 TreeFam:TF300416 EvolutionaryTrace:O15118 GeneWiki:NPC1 GenomeRNAi:4864 NextBio:18738 PRO:PR:O15118 ArrayExpress:O15118 Bgee:O15118 CleanEx:HS_NPC1 Genevestigator:O15118 TIGRFAMs:TIGR00917 Uniprot:O15118)

HSP 1 Score: 122.094 bits (305), Expect = 7.040e-29
Identity = 79/271 (29.15%), Postives = 123/271 (45.39%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            CV  G CG    +  G   +  C   GPP  +      L+++ CP F    + ++CC   Q++ LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K LQYY    F N++YN C+DV  PS +   +G +CG     C     + YM    +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C          + +   I G+D + ++M + +  F + F 
Sbjct:   25 CVWYGECG----IAYGD-KRYNCEYSGPPKPLPKDGYDLVQELCPGFFFG-NVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFP---VHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT--ILGLDAMYVIMWITYMAFLLVFF 284          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:Q8MI49 "Mutant Niemann-Pick C1" species:9685 "Felis catus" [GO:0005635 "nuclear envelope" evidence=ISS] [GO:0005783 "endoplasmic reticulum" evidence=ISS] [GO:0005887 "integral component of plasma membrane" evidence=ISS] [GO:0007041 "lysosomal transport" evidence=ISS] [GO:0008206 "bile acid metabolic process" evidence=ISS] [GO:0042632 "cholesterol homeostasis" evidence=ISS] [GO:0048471 "perinuclear region of cytoplasm" evidence=ISS] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0048471 GO:GO:0007165 GO:GO:0005887 GO:GO:0005635 GO:GO:0008206 GO:GO:0042632 GO:GO:0007041 GO:GO:0030301 GO:GO:0008158 eggNOG:NOG149152 HOVERGEN:HBG003913 TIGRFAMs:TIGR00917 EMBL:AF503633 ProteinModelPortal:Q8MI49 STRING:9685.ENSFCAP00000000483 Uniprot:Q8MI49)

HSP 1 Score: 122.094 bits (305), Expect = 7.502e-29
Identity = 78/271 (28.78%), Postives = 126/271 (46.49%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            C+  G CG    +  G   +  C   GPP  +      L+++ CP F  + + ++CC  +Q++ LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K LQYY    F N++YN C+DV  PS +   +G +CG     C     + YM +  +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C      +       + I G+D + ++M + +  F + F 
Sbjct:   25 CIWYGECG----IASGD-KRYNCKYSGPPKPLPKDGYDLVQELCPGFFFD-NVSLCCDVQQLQTLKDNLQLPLQFLSRCPSCFYNLVNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYIGESFANAMYNACRDVEAPSSNDKALGLLCGKDAEACNATNWIEYMFSKDNGQAPFTITPIFSDLP---THGMEPMNNATKGCDESVDEVTGPCSCQDCSIVCGPKP--QPPPPPVPWRILGLDAMYVIMWITYMAFLLVFF 284          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:NPC1 "Niemann-Pick C1 protein" species:9823 "Sus scrofa" [GO:0005576 "extracellular region" evidence=IEA] [GO:0005635 "nuclear envelope" evidence=IEA] [GO:0005765 "lysosomal membrane" evidence=IEA] [GO:0005768 "endosome" evidence=IEA] [GO:0005783 "endoplasmic reticulum" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IEA] [GO:0006486 "protein glycosylation" evidence=IEA] [GO:0006897 "endocytosis" evidence=IEA] [GO:0006914 "autophagy" evidence=IEA] [GO:0007628 "adult walking behavior" evidence=IEA] [GO:0008158 "hedgehog receptor activity" evidence=IEA] [GO:0015485 "cholesterol binding" evidence=IEA] [GO:0016242 "negative regulation of macroautophagy" evidence=IEA] [GO:0031982 "vesicle" evidence=IEA] [GO:0033344 "cholesterol efflux" evidence=IEA] [GO:0042493 "response to drug" evidence=IEA] [GO:0045121 "membrane raft" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IEA] [GO:0071383 "cellular response to steroid hormone stimulus" evidence=IEA] [GO:0071404 "cellular response to low-density lipoprotein particle stimulus" evidence=IEA] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0005794 GO:GO:0048471 GO:GO:0007165 GO:GO:0005576 GO:GO:0005887 GO:GO:0005635 GO:GO:0006914 GO:GO:0045121 GO:GO:0042493 GO:GO:0005768 GO:GO:0006486 GO:GO:0006897 GO:GO:0005764 GO:GO:0015485 GO:GO:0033344 GO:GO:0007628 GO:GO:0031982 GO:GO:0008158 GO:GO:0071404 GO:GO:0071383 GO:GO:0016242 GeneTree:ENSGT00680000099777 OrthoDB:EOG7QRQT0 TreeFam:TF300416 TIGRFAMs:TIGR00917 OMA:ITRAFTM EMBL:CU657945 Ensembl:ENSSSCT00000004106 Uniprot:F1SBB5)

HSP 1 Score: 121.709 bits (304), Expect = 1.097e-28
Identity = 79/271 (29.15%), Postives = 123/271 (45.39%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            CV  G CG    +  G   +  C   GPP  +      L+++ CP F    + ++CC  +Q+R LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K L+YY    F N++YN C+DV  PS +   +G +CG     C     + YM    +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C      +       + I G+D + ++M   +  F + F 
Sbjct:   25 CVWYGECG----IAYGD-KRYNCRYSGPPKPLPEDGYDLVQELCPGFFFG-NVSLCCDVQQLRTLKDNLQLPLQFLSRCPSCFYNLMNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELEYYVGETFANAMYNACRDVEAPSSNEKALGLLCGREAQACNATNWIEYMFNKDNGQAPFTITPIFSDLP---THGMEPMNNATKGCDESVDEVTGPCSCQDCSIVCGPKP--QPPPPPVPWRILGLDAMYVIMWSSYMAFLIVFF 284          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:NPC1 "Niemann-Pick C1 protein" species:9823 "Sus scrofa" [GO:0005576 "extracellular region" evidence=ISS] [GO:0005635 "nuclear envelope" evidence=ISS] [GO:0005764 "lysosome" evidence=ISS] [GO:0005765 "lysosomal membrane" evidence=IEA] [GO:0005783 "endoplasmic reticulum" evidence=ISS] [GO:0005887 "integral component of plasma membrane" evidence=ISS] [GO:0006486 "protein glycosylation" evidence=ISS] [GO:0007041 "lysosomal transport" evidence=ISS] [GO:0008158 "hedgehog receptor activity" evidence=IEA] [GO:0008203 "cholesterol metabolic process" evidence=IEA] [GO:0008206 "bile acid metabolic process" evidence=ISS] [GO:0015485 "cholesterol binding" evidence=ISS] [GO:0030301 "cholesterol transport" evidence=ISS] [GO:0031902 "late endosome membrane" evidence=IEA] [GO:0042632 "cholesterol homeostasis" evidence=ISS] [GO:0048471 "perinuclear region of cytoplasm" evidence=ISS] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0048471 GO:GO:0007165 GO:GO:0005576 GO:GO:0005887 GO:GO:0005635 GO:GO:0031902 GO:GO:0005765 GO:GO:0008206 GO:GO:0006486 GO:GO:0008203 GO:GO:0005764 GO:GO:0015485 GO:GO:0042632 GO:GO:0007041 GO:GO:0030301 GO:GO:0008158 eggNOG:NOG149152 KO:K12385 CTD:4864 HOVERGEN:HBG003913 TIGRFAMs:TIGR00917 HOGENOM:HOG000036674 EMBL:AF169635 RefSeq:NP_999487.1 UniGene:Ssc.1533 ProteinModelPortal:P56941 STRING:9823.ENSSSCP00000004014 GeneID:397591 KEGG:ssc:397591 Uniprot:P56941)

HSP 1 Score: 121.324 bits (303), Expect = 1.421e-28
Identity = 79/271 (29.15%), Postives = 123/271 (45.39%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            CV  G CG    +  G   +  C   GPP  +      L+++ CP F    + ++CC  +Q+R LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K L+YY    F N++YN C+DV  PS +   +G +CG     C     + YM    +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C      +       + I G+D + ++M   +  F + F 
Sbjct:   25 CVWYGECG----IASGD-KRYNCRYSGPPKPLPEDGYDLVQELCPGFFFG-NVSLCCDVQQLRTLKDNLQLPLQFLSRCPSCFYNLMNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELEYYVGETFANAMYNACRDVEAPSSNEKALGLLCGREAQACNATNWIEYMFNKDNGQAPFTITPIFSDLP---THGMEPMNNATKGCDESVDEVTGPCSCQDCSIVCGPKP--QPPPPPVPWRILGLDAMYVIMWSSYMAFLIVFF 284          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:npc1 "Niemann-Pick disease, type C1" species:7955 "Danio rerio" [GO:0008158 "hedgehog receptor activity" evidence=IEA] [GO:0016021 "integral component of membrane" evidence=IEA] [GO:0016020 "membrane" evidence=IEA] [GO:0030301 "cholesterol transport" evidence=IEA] [GO:0001666 "response to hypoxia" evidence=IDA] [GO:0006869 "lipid transport" evidence=ISS] [GO:0055113 "epiboly involved in gastrulation with mouth forming second" evidence=IMP] [GO:0035855 "megakaryocyte development" evidence=IMP] [GO:0009790 "embryo development" evidence=IMP] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 ZFIN:ZDB-GENE-030131-3161 GO:GO:0016021 GO:GO:0007165 GO:GO:0001666 GO:GO:0006869 GO:GO:0035855 GO:GO:0055113 GO:GO:0030301 GO:GO:0008158 TIGRFAMs:TIGR00917 EMBL:JF951427 UniGene:Dr.108239 Uniprot:F6N6I8)

HSP 1 Score: 121.324 bits (303), Expect = 1.488e-28
Identity = 83/295 (28.14%), Postives = 136/295 (46.10%), Query Frame = 0

Query:    6 LFVFILLKSVETENVEG-HCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKV--LQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
            +F  +L   + +  V G HC+  G CG  P V      KL C   GP   +    ++L+++ CP       + +CC  +Q+  LKS  +      S CP C +N   +FC+ TC P QS+F++V        D  +E  +  V  + YY    F ++++N C+DV  PS +I  +G +CG   ++CTP+  + YM + S+   PF I+  ++D P +        +  T  C       S PCSC +C   C            +I    G+D +S +M   +  F + F  V++
Sbjct:    9 IFRLLLATVLLSHWVHGQHCIWYGECGNSPNVPE---KKLNCNYTGPAVPLPNEGQELLQELCPRLVYA-DNRVCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQFISV-------KDFLKEKNLTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTPQIWIQYMFSISNGQVPFGIEPIFTDVPVQ---GMTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIIL--GLDAMSFIMWCSYIAFLLIFFGVVL 287          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:NPC1 "Uncharacterized protein" species:9031 "Gallus gallus" [GO:0005576 "extracellular region" evidence=IEA] [GO:0005635 "nuclear envelope" evidence=IEA] [GO:0005765 "lysosomal membrane" evidence=IEA] [GO:0005768 "endosome" evidence=IEA] [GO:0005783 "endoplasmic reticulum" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IEA] [GO:0006486 "protein glycosylation" evidence=IEA] [GO:0006897 "endocytosis" evidence=IEA] [GO:0006914 "autophagy" evidence=IEA] [GO:0007628 "adult walking behavior" evidence=IEA] [GO:0008158 "hedgehog receptor activity" evidence=IEA] [GO:0015485 "cholesterol binding" evidence=IEA] [GO:0016242 "negative regulation of macroautophagy" evidence=IEA] [GO:0031982 "vesicle" evidence=IEA] [GO:0033344 "cholesterol efflux" evidence=IEA] [GO:0042493 "response to drug" evidence=IEA] [GO:0045121 "membrane raft" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IEA] [GO:0071383 "cellular response to steroid hormone stimulus" evidence=IEA] [GO:0071404 "cellular response to low-density lipoprotein particle stimulus" evidence=IEA] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0016021 GO:GO:0007165 GO:GO:0030301 GO:GO:0008158 GeneTree:ENSGT00680000099777 OrthoDB:EOG7QRQT0 TreeFam:TF300416 TIGRFAMs:TIGR00917 EMBL:AADN03002550 Ensembl:ENSGALT00000024240 Uniprot:F1NQT4)

HSP 1 Score: 120.168 bits (300), Expect = 3.531e-28
Identity = 85/278 (30.58%), Postives = 131/278 (47.12%), Query Frame = 0

Query:   23 HCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPH-FESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKI--WGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
             CV  G CG    V  G   +  C  +GPP  +      LM++ CP  F   +S+  CC   Q++ LK+  +      S CP+C YN+  +FC+ TC P QS+FLNV+  I  + P  K  +  + + LQY+    F N +YN CKDV  PS ++  +G +CG     C     + YM    +  +PF I   +SD P    H     +  T  C+      + PCSC +C + C          + ++ +  G+D + I+M + +  F + F F LV
Sbjct:   33 QCVWYGECG----VASGD-KRYNCAYDGPPIALPKGGYDLMQELCPGLFFGNVST--CCDILQLQTLKNNLQLPLQFLSRCPSCFYNLINLFCELTCSPNQSEFLNVTSTIPYYDPVSKENKSSITE-LQYFIGERFANEMYNACKDVEAPSSNVKALGLLCGKDVKDCNATNWIEYMFNKDNGQTPFSIIPIFSDAP---VHGMNPMNNATKGCNESVDDSTGPCSCQDCSIVCGPKPQPPPLPAPWLLF--GLDAVYIIMWISYMGFLLIF-FALV 296          

BLAST of EMLSAG00000002936 vs. GO
Match: - (symbol:NPC1 "NPC1 protein" species:9913 "Bos taurus" [GO:0005576 "extracellular region" evidence=IEA] [GO:0005635 "nuclear envelope" evidence=IEA] [GO:0005765 "lysosomal membrane" evidence=IEA] [GO:0005768 "endosome" evidence=IEA] [GO:0005783 "endoplasmic reticulum" evidence=IEA] [GO:0005794 "Golgi apparatus" evidence=IEA] [GO:0005887 "integral component of plasma membrane" evidence=IEA] [GO:0006486 "protein glycosylation" evidence=IEA] [GO:0006897 "endocytosis" evidence=IEA] [GO:0006914 "autophagy" evidence=IEA] [GO:0007628 "adult walking behavior" evidence=IEA] [GO:0008158 "hedgehog receptor activity" evidence=IEA] [GO:0015485 "cholesterol binding" evidence=IEA] [GO:0016242 "negative regulation of macroautophagy" evidence=IEA] [GO:0031982 "vesicle" evidence=IEA] [GO:0033344 "cholesterol efflux" evidence=IEA] [GO:0042493 "response to drug" evidence=IEA] [GO:0045121 "membrane raft" evidence=IEA] [GO:0048471 "perinuclear region of cytoplasm" evidence=IEA] [GO:0071383 "cellular response to steroid hormone stimulus" evidence=IEA] [GO:0071404 "cellular response to low-density lipoprotein particle stimulus" evidence=IEA] InterPro:IPR000731 InterPro:IPR003392 InterPro:IPR004765 Pfam:PF02460 PROSITE:PS50156 GO:GO:0005783 GO:GO:0005794 GO:GO:0048471 GO:GO:0007165 GO:GO:0005576 GO:GO:0005887 GO:GO:0005635 GO:GO:0006914 GO:GO:0045121 GO:GO:0042493 GO:GO:0005768 GO:GO:0006486 GO:GO:0006897 GO:GO:0005764 GO:GO:0015485 GO:GO:0033344 GO:GO:0007628 GO:GO:0031982 GO:GO:0008158 GO:GO:0071404 GO:GO:0071383 GO:GO:0016242 eggNOG:NOG149152 GeneTree:ENSGT00680000099777 OMA:ENNARDI OrthoDB:EOG7QRQT0 HOVERGEN:HBG003913 TreeFam:TF300416 TIGRFAMs:TIGR00917 HOGENOM:HOG000036674 EMBL:DAAA02056610 EMBL:DAAA02056611 EMBL:BC151276 UniGene:Bt.7157 STRING:9913.ENSBTAP00000020219 Ensembl:ENSBTAT00000020219 InParanoid:B0JYK2 Uniprot:B0JYK2)

HSP 1 Score: 120.168 bits (300), Expect = 3.745e-28
Identity = 81/288 (28.12%), Postives = 127/288 (44.10%), Query Frame = 0

Query:    7 FVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            F  +LL     +     C+  G CG    +  G   +  C   GPP  +      L+++ CP F    + ++CC  +Q+  LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K LQYY    F N++YN C+DV  PS +   +G +CG   + C     + YM    +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C   C      +       + I G+D + ++M   +  F + F 
Sbjct:    8 FGLLLLLFCPAQVFSQSCIWYGECG----IASGD-KRYNCRYSGPPEPLPQDGYDLVQELCPGFFFG-NVSLCCDVQQLHTLKDNLQLPLQFLSRCPSCFYNLVNLFCELTCSPRQSQFLNVTATEDYVDPATNQTKTNVKELQYYVGESFANAMYNSCRDVEAPSSNEKALGLLCGREASACNATNWIEYMFNKDNGQAPFTITPVFSDLP---THGMEPMNNATKGCDESVDEVTGPCSCQDCSAVCGPKP--QPPPPPVPWRILGLDAMYVIMWSTYMAFLLVFF 284          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592794335|gb|GAXK01160233.1| (TSA: Calanus finmarchicus comp142827_c0_seq2 transcribed RNA sequence)

HSP 1 Score: 177.178 bits (448), Expect = 4.934e-48
Identity = 103/307 (33.55%), Postives = 162/307 (52.77%), Query Frame = 0

Query:    5 MLFVFILLKSVETENVE-GHCVLRGICGKDPTVT---VGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISS-NICCTKEQIRDLKSQFKS-LDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGP-------NDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQI---DFGKYQTSSFI-FYIGGIDGLSIVMGVIFSVFTVAFL 293
            ++F F  L+ V     E G C+    CG D         ++  L C   GP         +L+K+ CPH  +E    N+CC+  Q++DL+  F +   LI   CPTC YN +K FCD TC  +Q+KF+     + GP       N  G+ V+M K + Y+    F + +++ CKDV FP+ S +IM  +CG+     CTP++  +++G+  +  +PF I++++  D       FEY+SP  ++C    PG S  C C NC  +CS     +F +     F  F +GG+DGLS++MG++FSV +V F+
Sbjct: 3334 LMFCFSTLQFVSQVTAEDGQCIWYDTCGWDQDYGPDGGNEVHFLNCHYTGPAKPASDEQVELIKELCPHMYTEGEDLNLCCSIRQLKDLQLNFGTPKTLIEELCPTCWYNFRKNFCDMTCSDQQNKFVRTDHIVEGPGFDNGYENYTGQNVQMVKDVTYFVTEQFASDLFDSCKDVQFPAVSDTIMYMLCGSWGSEYCTPRRWFDFLGSVDNGYAPFTINYEFDTDDDISITDFEYHSPEVISCQDTAPGYSTGCGCANCPAACSGSGVPEFNREDDKPFYDFKLGGLDGLSVIMGLVFSVGSVLFI 4254          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592794336|gb|GAXK01160232.1| (TSA: Calanus finmarchicus comp142827_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 177.178 bits (448), Expect = 4.966e-48
Identity = 103/307 (33.55%), Postives = 162/307 (52.77%), Query Frame = 0

Query:    5 MLFVFILLKSVETENVE-GHCVLRGICGKDPTVT---VGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISS-NICCTKEQIRDLKSQFKS-LDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGP-------NDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQI---DFGKYQTSSFI-FYIGGIDGLSIVMGVIFSVFTVAFL 293
            ++F F  L+ V     E G C+    CG D         ++  L C   GP         +L+K+ CPH  +E    N+CC+  Q++DL+  F +   LI   CPTC YN +K FCD TC  +Q+KF+     + GP       N  G+ V+M K + Y+    F + +++ CKDV FP+ S +IM  +CG+     CTP++  +++G+  +  +PF I++++  D       FEY+SP  ++C    PG S  C C NC  +CS     +F +     F  F +GG+DGLS++MG++FSV +V F+
Sbjct: 3354 LMFCFSTLQFVSQVTAEDGQCIWYDTCGWDQDYGPDGGNEVHFLNCHYTGPAKPASDEQVELIKELCPHMYTEGEDLNLCCSIRQLKDLQLNFGTPKTLIEELCPTCWYNFRKNFCDMTCSDQQNKFVRTDHIVEGPGFDNGYENYTGQNVQMVKDVTYFVTEQFASDLFDSCKDVQFPAVSDTIMYMLCGSWGSEYCTPRRWFDFLGSVDNGYAPFTINYEFDTDDDISITDFEYHSPEVISCQDTAPGYSTGCGCANCPAACSGSGVPEFNREDDKPFYDFKLGGLDGLSVIMGLVFSVGSVLFI 4274          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592765109|gb|GAXK01189459.1| (TSA: Calanus finmarchicus comp620364_c3_seq3 transcribed RNA sequence)

HSP 1 Score: 171.014 bits (432), Expect = 3.002e-46
Identity = 103/314 (32.80%), Postives = 163/314 (51.91%), Query Frame = 0

Query:    1 MLVPMLFVFILLKSVETENVE-GHCVLRGICGKDPTVTVGKIPK-LLCVDEGPPTEMDASLKKLMKKACPHFESEISS--NICCTKEQIRDLKSQFK-SLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPND---KGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICG-TAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYI-GGIDGLSIVMGVIFSVFTVAFLFVL--VQQKNQ 302
            +L    F+ I   S  + +V  G C+    CG DP          L+C  +GP  ++   +  +++  CPH  ++  S  ++CC+  Q++D+K  F+    LIA  CPTC YN +K FCD TCHP QS+F+ V   + G  D    GE   M K + Y+ + +F    Y  CK+V FPS S ++MG +CG      CT K+  +YMG+ ++  SPF+I++ Y       P  + Y++P    C + P      C C +C  +C +I+  ++ T    + I  G+DGL   M +IF V TV F+ +L  V ++N+
Sbjct:  249 ILPTAWFLLIFSHSTWSASVPPGQCIWHDRCGPDPDYPPSDSQHYLMCQYDGPARQVTQEMALIVQDICPHLSNKDGSLPSLCCSLNQLQDMKKNFELPAGLIAQTCPTCYYNFRKNFCDLTCHPHQSEFVRVDGVVHGLGDGEYAGENKTMVKAVTYHVSEEFNTRTYESCKNVQFPSTSDTVMGLLCGPHGSKDCTAKRWFDYMGSITNGYSPFQINYDYGSG--HTPDNYTYHNPPVTPCQMSPQPGVAACGCADCPQAC-KINIPQFITQDVNWQIFPGVDGLGFFMFIIFFVGTVIFITILCVVGRRNK 1181          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592765111|gb|GAXK01189457.1| (TSA: Calanus finmarchicus comp620364_c3_seq1 transcribed RNA sequence)

HSP 1 Score: 171.014 bits (432), Expect = 3.440e-46
Identity = 103/314 (32.80%), Postives = 163/314 (51.91%), Query Frame = 0

Query:    1 MLVPMLFVFILLKSVETENVE-GHCVLRGICGKDPTVTVGKIPK-LLCVDEGPPTEMDASLKKLMKKACPHFESEISS--NICCTKEQIRDLKSQFK-SLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPND---KGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICG-TAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYI-GGIDGLSIVMGVIFSVFTVAFLFVL--VQQKNQ 302
            +L    F+ I   S  + +V  G C+    CG DP          L+C  +GP  ++   +  +++  CPH  ++  S  ++CC+  Q++D+K  F+    LIA  CPTC YN +K FCD TCHP QS+F+ V   + G  D    GE   M K + Y+ + +F    Y  CK+V FPS S ++MG +CG      CT K+  +YMG+ ++  SPF+I++ Y       P  + Y++P    C + P      C C +C  +C +I+  ++ T    + I  G+DGL   M +IF V TV F+ +L  V ++N+
Sbjct:  249 ILPTAWFLLIFSHSTWSASVPPGQCIWHDRCGPDPDYPPSDSQHYLMCQYDGPARQVTQEMALIVQDICPHLSNKDGSLPSLCCSLNQLQDMKKNFELPAGLIAQTCPTCYYNFRKNFCDLTCHPHQSEFVRVDGVVHGLGDGEYAGENKTMVKAVTYHVSEEFNTRTYESCKNVQFPSTSDTVMGLLCGPHGSKDCTAKRWFDYMGSITNGYSPFQINYDYGSG--HTPDNYTYHNPPVTPCQMSPQPGVAACGCADCPQAC-KINIPQFITQDVNWQIFPGVDGLGFFMFIIFFVGTVIFITILCVVGRRNK 1181          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592765108|gb|GAXK01189460.1| (TSA: Calanus finmarchicus comp620364_c3_seq4 transcribed RNA sequence)

HSP 1 Score: 169.474 bits (428), Expect = 1.134e-45
Identity = 102/307 (33.22%), Postives = 162/307 (52.77%), Query Frame = 0

Query:   10 ILLKSVETENVE---GHCVLRGICGKDPTVTVGKIPK-LLCVDEGPPTEMDASLKKLMKKACPHFESEISS--NICCTKEQIRDLKSQFK-SLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPND---KGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTL-CTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYI-GGIDGLSIVMGVIFSVFTVAFLFVL--VQQKNQ 302
            +LL S  T ++    G C+    CG DP          L+C  +GP  ++   +  +++  CPH  ++  S  ++CC+  Q++D+K  F+    LIA  CPTC YN +K FCD TCHP QS+F+ V   + G  D    GE   M K + Y+ + +F    Y  CK+V FPS S ++MG +CG   +  CT K+  +YMG+ ++  SPF+I++ Y       P  + Y++P    C + P      C C +C  +C +I+  ++ T    + I  G+DGL   M +IF V TV F+ +L  V ++N+
Sbjct:  264 LLLFSHSTWSISVPPGQCIWHDRCGPDPDYPPSDSQHYLMCQYDGPARQVTQEMALIVQDICPHLSNKDGSLPSLCCSLNQLQDMKKNFELPAGLIAQTCPTCYYNFRKNFCDLTCHPHQSEFVRVDGVVHGLGDGEYAGENKTMVKAVTYHVSEEFNTRTYESCKNVQFPSTSDTVMGLLCGPHGSKDCTAKRWFDYMGSITNGYSPFQINYDYGSG--HTPDNYTYHNPPVTPCQMSPQPGVAACGCADCPQAC-KINIPQFITQDVNWQIFPGVDGLGFFMFIIFFVGTVIFITILCVVGRRNK 1175          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592765110|gb|GAXK01189458.1| (TSA: Calanus finmarchicus comp620364_c3_seq2 transcribed RNA sequence)

HSP 1 Score: 169.474 bits (428), Expect = 1.294e-45
Identity = 102/307 (33.22%), Postives = 162/307 (52.77%), Query Frame = 0

Query:   10 ILLKSVETENVE---GHCVLRGICGKDPTVTVGKIPK-LLCVDEGPPTEMDASLKKLMKKACPHFESEISS--NICCTKEQIRDLKSQFK-SLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPND---KGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTL-CTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYI-GGIDGLSIVMGVIFSVFTVAFLFVL--VQQKNQ 302
            +LL S  T ++    G C+    CG DP          L+C  +GP  ++   +  +++  CPH  ++  S  ++CC+  Q++D+K  F+    LIA  CPTC YN +K FCD TCHP QS+F+ V   + G  D    GE   M K + Y+ + +F    Y  CK+V FPS S ++MG +CG   +  CT K+  +YMG+ ++  SPF+I++ Y       P  + Y++P    C + P      C C +C  +C +I+  ++ T    + I  G+DGL   M +IF V TV F+ +L  V ++N+
Sbjct:  264 LLLFSHSTWSISVPPGQCIWHDRCGPDPDYPPSDSQHYLMCQYDGPARQVTQEMALIVQDICPHLSNKDGSLPSLCCSLNQLQDMKKNFELPAGLIAQTCPTCYYNFRKNFCDLTCHPHQSEFVRVDGVVHGLGDGEYAGENKTMVKAVTYHVSEEFNTRTYESCKNVQFPSTSDTVMGLLCGPHGSKDCTAKRWFDYMGSITNGYSPFQINYDYGSG--HTPDNYTYHNPPVTPCQMSPQPGVAACGCADCPQAC-KINIPQFITQDVNWQIFPGVDGLGFFMFIIFFVGTVIFITILCVVGRRNK 1175          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592809975|gb|GAXK01144593.1| (TSA: Calanus finmarchicus comp58031_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 168.318 bits (425), Expect = 6.140e-45
Identity = 102/305 (33.44%), Postives = 160/305 (52.46%), Query Frame = 0

Query:    2 LVPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPK-LLCVDEGPPTEMDASLKKLMKKACPHFESEISS--NICCTKEQIRDLKSQFK-SLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPND---KGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPP-PGESVPCSCTNCELSCSQIDFGKYQTSSFIFYI-GGIDGLSIVMGVIFSVFTVAFLFVL 296
            LVP L    ++ S  +    G CV    CG+DP          L+C  +G          +++++ CPH   E  S   +CC+  Q+ D+K  F+    LI   CPTC YN +K FCD TCHP QS F+ V     GP D   KG+E EM K + Y+ + +F +  Y  CK+V FP+QS ++MG +CG      CT K+  +YMG+ S+  SPF+I+++Y            Y++P+   C++P  PG S  C C +C  +C+ ++  ++      F I  G+DGL  +M ++F V ++ F+ ++
Sbjct: 3587 LVPTL---AMVDSSYSMYPSGQCVWYDKCGQDPDYPPSDTQHYLMCKYDGQAKSASHKQIEILQEVCPHLLPEDGSLPELCCSLNQLEDMKKNFELPKGLIGQTCPTCYYNFRKNFCDVTCHPRQSNFVRVDKVAKGPGDGDYKGQEKEMVKSVTYFVSEEFNDRTYESCKNVQFPAQSDTVMGLLCGAYGSKKCTAKRWFDYMGSISNGYSPFQINYEYGSSQTS-GDNHTYHNPSATACNLPAQPGMSA-CGCADCPQACT-VNIPQFADRDPNFQIVRGVDGLVFIMIIVFVVGSIIFVAIV 4483          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592822728|gb|GAXK01131840.1| (TSA: Calanus finmarchicus comp1047552_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 97.4413 bits (241), Expect = 2.140e-23
Identity = 53/154 (34.42%), Postives = 82/154 (53.25%), Query Frame = 0

Query:  111 KVFCDFTCHPEQSKFLNVSVKIWGP-------NDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQ 256
            K FCD TC  +Q +F+     + GP       N  G+ V M K + Y+A+ DFV  VY  CK+V FP+ S +IM  +CG      C P +  ++MG+ ++  +PFKI++ YS+D        +Y++P  + C+   PG    C C +C+ S  Q
Sbjct:   36 KNFCDMTCSNQQDQFIRADNLVEGPGFDNGYVNYTGQMVTMVKDVTYFAHTDFVTDVYESCKNVQFPAVSDTIMYMLCGEWGSEFCNPFRWFDFMGSVNNGYAPFKINYDYSNDLTS-NDGHQYHNPEVIPCNDVAPGYDRSCGCEDCQYSSCQ 494          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592772390|gb|GAXK01182178.1| (TSA: Calanus finmarchicus comp5078993_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 90.1225 bits (222), Expect = 2.702e-20
Identity = 63/210 (30.00%), Postives = 90/210 (42.86%), Query Frame = 0

Query:   78 ICCTKEQIRDLKSQFKS-LDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGP-------NDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSF--IFYIGGIDGL 277
            +CC+  Q++DL+  F +   LI   CPTC YN +K FCD TC  +QS F+     + GP       N  G+ V M K + Y+A++DFV   Y  CKDV FP+ S +IM  I                                             Y++P  + C+   PG S+ C C NC  +CS      Y T  +   + I G +G+
Sbjct:  134 LCCSIRQLKDLQINFGTPKALIEDLCPTCWYNFRKNFCDMTCSDQQSTFVRADQLVEGPGFDNGYNNYTGQNVTMVKSVTYFAHVDFVIDSYESCKDVQFPAVSDTIMKDISSDG---------------------------------------HNYHNPAIIPCNSTAPGYSMGCDCANCPSACSDDQCIWYDTCGWDPDYGIDGGNGI 646          

BLAST of EMLSAG00000002936 vs. C. finmarchicus
Match: gi|592819816|gb|GAXK01134752.1| (TSA: Calanus finmarchicus comp705228_c0_seq1 transcribed RNA sequence)

HSP 1 Score: 64.3142 bits (155), Expect = 1.495e-11
Identity = 39/123 (31.71%), Postives = 64/123 (52.03%), Query Frame = 0

Query:    1 MLVPMLFVFILLKSVETENVEGHCVLRGICGKD----PTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISS-NICCTKEQIRDLKSQFKS-LDLIASHCPTCTYNMKKVFCDFT 117
            + + +L  +++L++V +      CV   +CG D    P    G +  L C   GP        ++L+K+ CPH  +E    N+CC+  Q+++L+  F +   LI + CPTC YN +K FCD T
Sbjct:    2 LHISILVTYLVLRNVASS--ANQCVWYDVCGWDQDYGPDGGNG-VHSLNCHYTGPAKPASEEQEELVKELCPHLYTEGEPLNLCCSLRQLKELQMNFGTPRALIEAMCPTCWYNFRKNFCDMT 361          

BLAST of EMLSAG00000002936 vs. L. salmonis peptides
Match: EMLSAP00000002936 (pep:novel supercontig:LSalAtl2s:LSalAtl2s168:234565:235661:-1 gene:EMLSAG00000002936 transcript:EMLSAT00000002936 description:"maker-LSalAtl2s168-augustus-gene-2.28")

HSP 1 Score: 631.328 bits (1627), Expect = 0.000e+0
Identity = 309/309 (100.00%), Postives = 309/309 (100.00%), Query Frame = 0

Query:    1 MLVPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQITAL 309
            MLVPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQITAL
Sbjct:    1 MLVPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQITAL 309          

BLAST of EMLSAG00000002936 vs. L. salmonis peptides
Match: EMLSAP00000001950 (pep:novel supercontig:LSalAtl2s:LSalAtl2s1345:18618:29195:1 gene:EMLSAG00000001950 transcript:EMLSAT00000001950 description:"maker-LSalAtl2s1345-snap-gene-0.7")

HSP 1 Score: 153.295 bits (386), Expect = 5.249e-41
Identity = 94/282 (33.33%), Postives = 145/282 (51.42%), Query Frame = 0

Query:   22 GHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPE--IPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQK 300
            G  +    C + P +       L C  +G   E  A L KL ++ CPH +   S  +CC+++Q+  ++  F     I   CPTC +N KK FC  TCHP+QS FL   V      +  EEV +   + YY   +FV  VY+ CK V+ PS S + +  +CG     LC+P +   Y+G+ S+  +PF+ID+ +S +     IP   ++Y+    +CDV   G S PCSC +CE +C    F + Q   +I  + G+DG   +M +IF V  + FL +++  K
Sbjct:   18 GRXIWFENCSQSPYLENNADKWLNCAYDGEAKE--APLLKL-ERICPHLDP--SEGVCCSEKQLDVMEKNFNISASILGRCPTCLHNFKKNFCAMTCHPQQSYFLQGQVMTSNHFETQEEVSVISNVTYYVADEFVQRVYDSCKXVVTPSVSGTALKLMCGKWGDKLCSPYRWFRYLGSLSNGFTPFQIDYVFSGETRHHPIPEGIQFYNTVVESCDVGVNG-SEPCSCADCESACEPPHFEETQVGFYI--VPGVDGTIFIMAIIFVVGXIIFLAIVIASK 291          

BLAST of EMLSAG00000002936 vs. L. salmonis peptides
Match: EMLSAP00000008403 (pep:novel supercontig:LSalAtl2s:LSalAtl2s513:547002:563743:1 gene:EMLSAG00000008403 transcript:EMLSAT00000008403 description:"maker-LSalAtl2s513-augustus-gene-5.4")

HSP 1 Score: 50.447 bits (119), Expect = 3.468e-7
Identity = 35/98 (35.71%), Postives = 52/98 (53.06%), Query Frame = 0

Query:  205 SPFKIDFKYSDDP-PEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSC-SQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQK 300
            +PF+IDF +S D    IP +  YY+     C++   G+S PCSCT+CE SC SQI   K     +  Y   I   S  M +IF +  + F+ V++  +
Sbjct:    3 TPFQIDFVFSGDKXASIPEEMSYYNTEIEPCNIRVNGKS-PCSCTDCESSCASQIINDKNHHLEYNNYRLNISSFS--MAIIFLIGFLIFVGVVITSR 97          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|83305902|sp|O15118.2|NPC1_HUMAN (RecName: Full=Niemann-Pick C1 protein; Flags: Precursor)

HSP 1 Score: 122.094 bits (305), Expect = 1.141e-29
Identity = 79/271 (29.15%), Postives = 123/271 (45.39%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            CV  G CG    +  G   +  C   GPP  +      L+++ CP F    + ++CC   Q++ LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K LQYY    F N++YN C+DV  PS +   +G +CG     C     + YM    +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C          + +   I G+D + ++M + +  F + F 
Sbjct:   25 CVWYGECG----IAYGD-KRYNCEYSGPPKPLPKDGYDLVQELCPGFFFG-NVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFP---VHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT--ILGLDAMYVIMWITYMAFLLVFF 284          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|8134591|sp|P56941.1|NPC1_PIG (RecName: Full=Niemann-Pick C1 protein; Flags: Precursor)

HSP 1 Score: 121.324 bits (303), Expect = 2.347e-29
Identity = 79/271 (29.15%), Postives = 123/271 (45.39%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV-KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            CV  G CG    +  G   +  C   GPP  +      L+++ CP F    + ++CC  +Q+R LK   +      S CP+C YN+  +FC+ TC P QS+FLNV+  + +      +     K L+YY    F N++YN C+DV  PS +   +G +CG     C     + YM    +  +PF I   +SD P    H  E  +  T  CD      + PCSC +C + C      +       + I G+D + ++M   +  F + F 
Sbjct:   25 CVWYGECG----IASGD-KRYNCRYSGPPKPLPEDGYDLVQELCPGFFFG-NVSLCCDVQQLRTLKDNLQLPLQFLSRCPSCFYNLMNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELEYYVGETFANAMYNACRDVEAPSSNEKALGLLCGREAQACNATNWIEYMFNKDNGQAPFTITPIFSDLP---THGMEPMNNATKGCDESVDEVTGPCSCQDCSIVCGPKP--QPPPPPVPWRILGLDAMYVIMWSSYMAFLIVFF 284          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|449081276|sp|O35604.2|NPC1_MOUSE (RecName: Full=Niemann-Pick C1 protein; Flags: Precursor)

HSP 1 Score: 115.161 bits (287), Expect = 2.753e-27
Identity = 83/276 (30.07%), Postives = 126/276 (45.65%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPH-FESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSV--KIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVL 296
            CV  G CG    +  G   +  C   GPP  +      L+++ CP  F   +S  +CC  +Q++ LKS  +      S CP+C YN+  +FC+ TC P QS+FLNV+     + P  + E     K L+Y+    F N++YN C+DV  PS +   +G +CG     C     + YM    +  +PF I   +SD         E     T  C+      + PCSC +C + C      +       + I G+D + ++M V +    VAFLFV 
Sbjct:   25 CVWYGECG----IATGD-KRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVS--LCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQ-ENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSIL---GMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKP--QPPPPPMPWRIWGLDAMYVIMWVTY----VAFLFVF 283          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|425906049|sp|Q9UHC9.2|NPCL1_HUMAN (RecName: Full=Niemann-Pick C1-like protein 1; Flags: Precursor)

HSP 1 Score: 104.76 bits (260), Expect = 9.725e-24
Identity = 66/279 (23.66%), Postives = 121/279 (43.37%), Query Frame = 0

Query:   22 GHCVLRGICGKDPTVT--VGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVS-VKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVL 296
            G+C     CGK+P ++  +  +  + C+   P  ++      L++K CP   +  ++  CC+ +Q+  L++       + + CP C+ N   + C  TC P QS F+NV+ V   G       V      Q+     F    Y+ C  V  P+ +   +G +CG     LC  ++ LN+ G   +  +P  I F   +    +    +  +     C+     +   CSC +C  SC  I   + Q     FY+G + G  +++ ++ SVF V  + ++
Sbjct:   31 GYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQH----SFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAI--ARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLV 303          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|73921247|sp|Q6T3U3.1|NPCL1_RAT (RecName: Full=Niemann-Pick C1-like protein 1; Flags: Precursor)

HSP 1 Score: 100.523 bits (249), Expect = 3.085e-22
Identity = 71/288 (24.65%), Postives = 124/288 (43.06%), Query Frame = 0

Query:   22 GHCVLRGICGKDPTVTVG--KIPKLLCVDEGPPTEMDASLKKLMKKACPH-FESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQ 305
            G C     CGK+P ++ G   +  + C+   P   +      L+++ CP  +    ++  CC+ +Q+  L+S       + + CP C+ N   + C  TC P+QS F+NV+  +      GE   +     +Y    F    Y  C  V  P+ +   +G +CG     LC  ++ LN+ G   +  +P  I F   +    +P   +  +     C+     +S  CSC +C  SC  I   +    S  FY+G + G  + + +IF+   V    VLV+ +   N+
Sbjct:   30 GVCTFYEECGKNPELSGGLTSLSNVSCLSNTPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVV--ERGAGEPPAVVAYEAFYQR-SFAEKAYESCSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKIAPCNESQGDDSAVCSCQDCAASCPVIPPPEALRPS--FYMGRMPGW-LALIIIFTAVFVLLSAVLVRLRVVSNR 311          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|73921246|sp|Q6T3U4.1|NPCL1_MOUSE (RecName: Full=Niemann-Pick C1-like protein 1; Flags: Precursor)

HSP 1 Score: 94.7449 bits (234), Expect = 2.581e-20
Identity = 69/286 (24.13%), Postives = 119/286 (41.61%), Query Frame = 0

Query:   10 ILLKSVETE-----NVEGHCVLRGICGKDPTVTVG--KIPKLLCVDEGPPTEMDASLKKLMKKACPH-FESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFS 286
            +LL S + E     +  G C     CGK+P ++ G   +  + C+   P   +      L+++ CP  +     +  CC+ +Q+  L S       + + CP C+ N   + C  TC P+QS F+NV+  +    D G+   +     +Y    F    Y  C  V  P+ +   +G +CG     LC  ++ LN+ G   +  +P  I F   +    +    +        C+     +S  CSC +C  SC  I        S  FY+G + G  + + +IF+
Sbjct:   13 LLLNSAQGELYTPTHKAGFCTFYEECGKNPELSGGLTSLSNISCLSNTPARHVTGDHLALLQRVCPRLYNGPNDTYACCSTKQLVSLDSSLSITKALLTRCPACSENFVSIHCHNTCSPDQSLFINVTRVV--QRDPGQLPAVVAYEAFYQR-SFAEKAYESCSRVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGKITPCNESQGEDSAACSCQDCAASCPVIPPPPALRPS--FYMGRMPGW-LALIIIFT 292          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|1100165154|sp|Q9VRC9.2|NPC1B_DROME (RecName: Full=Niemann-Pick type protein homolog 1B; Flags: Precursor)

HSP 1 Score: 89.7373 bits (221), Expect = 1.327e-18
Identity = 65/243 (26.75%), Postives = 103/243 (42.39%), Query Frame = 0

Query:   60 KKLMKKACPHFESEISS-------NICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLF 294
            + +  K CP    E          ++CC   QI  ++S     D + S CPTCT NM    C  TC    + FL         ND G  V+  K + Y    D V+ +YN C  +         M   CG+     C  ++   +MG  S    PF+I++K+S+D  E  ++  Y   + L C      +S  C+C +CE SC   D         ++ I G+ G++ ++ +I +     F+F
Sbjct:   55 EAIFAKRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLTAYND---TNDAG--VDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAEEGSNEI-YLDLSPLKCG-ESYEDSYACACIDCEESCPLTD--APTGPDELWKIAGLYGVTFILALIIACALSFFIF 288          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|74676548|sp|Q12200.1|NPC1_YEAST (RecName: Full=Niemann-Pick type C-related protein 1; Flags: Precursor)

HSP 1 Score: 87.4261 bits (215), Expect = 7.058e-18
Identity = 61/236 (25.85%), Postives = 108/236 (45.76%), Query Frame = 0

Query:   24 CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMG--TPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQI 257
            C + G CGK  +V   ++P  +     PP   D +  KL+ + C     E+    CCTK+Q+  L+   +    + S CP C  N   +FC FTC  +Q +F+N++          E+ ++   L  + N  + +  Y+ CK++ F + +   M  I G A       + L ++G   P    SPF+I++KY  D      +++ ++     CD         C+C++C+ SC  +
Sbjct:   23 CAMYGNCGK-KSVFGNELPCPVPRSFEPPVLSDET-SKLLVEVCGEEWKEVRY-ACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNIT----KVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNY---SQFLKFLGDAKPMLGGSPFQINYKY--DLANEEKEWQEFNDEVYACD----DAQYKCACSDCQESCPHL 242          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|37999494|sp|Q19127.2|NPC1_CAEEL (RecName: Full=Niemann-Pick C1 protein homolog 1; Flags: Precursor)

HSP 1 Score: 84.7297 bits (208), Expect = 6.031e-17
Identity = 83/296 (28.04%), Postives = 128/296 (43.24%), Query Frame = 0

Query:    6 LFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDAS--LKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGE----EVEMAKV----LQYYANIDFVNSVYNGCKDVLFPSQ-SISIMGFICGTAPTLCTPKKLLNYMGTPS-SITSPFKIDFKYSDDPPEIP--HKFEYYSPNTLTCDVPPPGESVPCSCTNC--ELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIF 285
            L +F LL      + +  C++RG+C K      G  P +       PT  D +    + M + CPH  +   + +CCT  Q   L  Q      I   CP+C  N  K++C+FTC P Q  F  VS+    P +K E    E + A+     ++Y  + DF   +++ CKDV F  Q ++ +M   C + P  CT    L ++GT +  +  P    F    DP + P   +  Y + N   CD         CS + C  E   + ID    +TS     + GI  L+I + + F
Sbjct:    4 LLIFCLLFGSIFHHGDAGCIMRGLCQKHTENAYG--PCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTG-DNKLCCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDF--VSISEMKPIEKKEGFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTFGGQPALRVM---CTSTP--CTLTNWLEFIGTQNLDLNIPIHTKFLLY-DPIKTPPSDRSTYMNVNFTGCDKSARVGWPACSTSECNKEEYANLIDLDDGKTSGQTCNVHGIACLNIFVMLAF 288          

BLAST of EMLSAG00000002936 vs. SwissProt
Match: gi|37999933|sp|P34389.2|NPC2_CAEEL (RecName: Full=Niemann-Pick C1 protein homolog 2; Flags: Precursor)

HSP 1 Score: 65.4698 bits (158), Expect = 1.427e-10
Identity = 40/153 (26.14%), Postives = 76/153 (49.67%), Query Frame = 0

Query:   64 KKACPHF-ESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITS-PFKIDFKYS 214
            +K C +  + E  + +CCT+ Q++ +  +  +   I   CP+C  N  K++C FTC P+QSKF+ V ++  GP +      +   +++  N DFV  +Y  C+   F +  +++     G   +    +    +MGT +   S P   +F++S
Sbjct:   70 EKYCSYLVQEEDKAQVCCTELQLKGMTDRISNAATILGSCPSCFDNFAKLWCQFTCSPDQSKFMKV-METTGPKN------VVVKMEFKVNRDFVEGLYESCRHTWF-ANGLALRLMSLGGKVSF---ENFYGFMGTKNLAQSIPINTEFQFS 211          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: XP_006570443.1 (PREDICTED: Niemann-Pick C1 protein isoform X2 [Apis mellifera])

HSP 1 Score: 121.324 bits (303), Expect = 1.162e-29
Identity = 91/309 (29.45%), Postives = 137/309 (44.34%), Query Frame = 0

Query:    5 MLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHF--ESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITS-PFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSC-SQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQITA 308
            +L ++  + S+     +GHC+  G C  D       + K  C   GPP  +D   +KL+ K CPH   +S    N CC   Q+R + +  K      S CP+C  N+ K FC+FTC  +QSKF+NV+        K  EVE    +  Y    ++   +N C  V  PS     M  +CG    + CT  K  +YMG  ++    PF+I +  +D+P +    F    P    C+      +  CSC +CE SC            S IF   G D  +++M + F   +  F+  +V   N+  QI A
Sbjct:   29 LLSIWTFINSISAAE-DGHCIWYGECYTDRF----NMHKKNCPYTGPPKLLDNDGQKLLAKNCPHLMIDSGNGINTCCDTNQLRTMDTNIKLASNFLSRCPSCLDNLVKHFCEFTCSTQQSKFINVT-----EIQKENEVEYINGINIYITDKYIEGTFNSCSKVSVPSTGQLAMDLMCGIWGASRCTAWKWFHYMGDAANNGYVPFQITYINTDEPID---SFIPVDPKVTPCNKALNKNTPACSCVDCEASCPVPPPVPPLPRPSTIF---GYDSYAVIMLITFICGSTLFILSIVCFSNR-KQIVA 320          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: XP_006570442.1 (PREDICTED: Niemann-Pick C1 protein isoform X1 [Apis mellifera])

HSP 1 Score: 120.939 bits (302), Expect = 1.478e-29
Identity = 91/309 (29.45%), Postives = 137/309 (44.34%), Query Frame = 0

Query:    5 MLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHF--ESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITS-PFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSC-SQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQITA 308
            +L ++  + S+     +GHC+  G C  D       + K  C   GPP  +D   +KL+ K CPH   +S    N CC   Q+R + +  K      S CP+C  N+ K FC+FTC  +QSKF+NV+        K  EVE    +  Y    ++   +N C  V  PS     M  +CG    + CT  K  +YMG  ++    PF+I +  +D+P +    F    P    C+      +  CSC +CE SC            S IF   G D  +++M + F   +  F+  +V   N+  QI A
Sbjct:   29 LLSIWTFINSISAAE-DGHCIWYGECYTDRF----NMHKKNCPYTGPPKLLDNDGQKLLAKNCPHLMIDSGNGINTCCDTNQLRTMDTNIKLASNFLSRCPSCLDNLVKHFCEFTCSTQQSKFINVT-----EIQKENEVEYINGINIYITDKYIEGTFNSCSKVSVPSTGQLAMDLMCGIWGASRCTAWKWFHYMGDAANNGYVPFQITYINTDEPID---SFIPVDPKVTPCNKALNKNTPACSCVDCEASCPVPPPVPPLPRPSTIF---GYDSYAVIMLITFICGSTLFILSIVCFSNR-KQIVA 320          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: gb|EFA11848.2| (Niemann-Pick C1 protein-like Protein [Tribolium castaneum])

HSP 1 Score: 119.013 bits (297), Expect = 7.744e-29
Identity = 83/291 (28.52%), Postives = 128/291 (43.99%), Query Frame = 0

Query:   14 SVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEM-DASLKKLMKKACPHFESEISS--NICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLN-VSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSIT--SPFKIDFKYSDDPPEIPH-KFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVL 296
            S   ++ + HCV  G C   PT      P      +GPP  + D +  + + K CPH  S+ S   N CC   Q+    +  +        CP+C  N+ +  CDFTC  +Q+ ++  V VK    N KG  VE    +  +   D++   Y  CK V  PS     +  +CG+   + C+  +  N+MGT        PF+I++  S  P +    K++  +P    C+     +S  CSC +CE SC            F   I G DG   +M ++F V T+ FL V+
Sbjct:   33 STSRKDTQAHCVWYGECNTSPTGLTQYCPY-----DGPPKPLNDTTALETLSKWCPHLISDSSQTINACCDAAQVATFATNIQLAANFLKRCPSCMMNLARHLCDFTCGQDQTNYMKIVEVK---NNTKG--VEYITAIDLFITNDYLEGTYKSCKQVSVPSSGQLALDLMCGSWGASKCSAMRWFNFMGTAGDTNPFVPFQINYLNSTGPVDKDGVKYQPLNPEITPCNKAFDSKSAACSCVDCEESCPVPPPQPPAPQPFT--IAGFDGYFFLMIIVFCVGTLMFLLVV 311          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: gb|KYB26045.1| (Niemann-Pick C1 protein-like Protein [Tribolium castaneum])

HSP 1 Score: 119.013 bits (297), Expect = 8.138e-29
Identity = 83/291 (28.52%), Postives = 128/291 (43.99%), Query Frame = 0

Query:   14 SVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEM-DASLKKLMKKACPHFESEISS--NICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLN-VSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSIT--SPFKIDFKYSDDPPEIPH-KFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVL 296
            S   ++ + HCV  G C   PT      P      +GPP  + D +  + + K CPH  S+ S   N CC   Q+    +  +        CP+C  N+ +  CDFTC  +Q+ ++  V VK    N KG  VE    +  +   D++   Y  CK V  PS     +  +CG+   + C+  +  N+MGT        PF+I++  S  P +    K++  +P    C+     +S  CSC +CE SC            F   I G DG   +M ++F V T+ FL V+
Sbjct:   33 STSRKDTQAHCVWYGECNTSPTGLTQYCPY-----DGPPKPLNDTTALETLSKWCPHLISDSSQTINACCDAAQVATFATNIQLAANFLKRCPSCMMNLARHLCDFTCGQDQTNYMKIVEVK---NNTKG--VEYITAIDLFITNDYLEGTYKSCKQVSVPSSGQLALDLMCGSWGASKCSAMRWFNFMGTAGDTNPFVPFQINYLNSTGPVDKDGVKYQPLNPEITPCNKAFDSKSAACSCVDCEESCPVPPPQPPAPQPFT--IAGFDGYFFLMIIVFCVGTLMFLLVV 311          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: gb|EEC13272.1| (Niemann-Pick type C1 domain-containing protein, putative [Ixodes scapularis])

HSP 1 Score: 118.242 bits (295), Expect = 1.310e-28
Identity = 76/233 (32.62%), Postives = 115/233 (49.36%), Query Frame = 0

Query:   69 HFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLT---CDVP-PPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
            HF    ++  CC    +++L      + L+   CP+C YN+ +VFC  TC P Q  F  V+ K   P  KG        L YY +  +    ++ C  + F   S++ +  +CG+    C P+ LL  +G   S+ SPF+IDF++SD P  +  K + Y P   T   C  P  PG+   CSC++C  +CS+I    Y      + I  +DG  IV G++FS+F V  L V V
Sbjct:   20 HFRG--ANKFCCDDHSVKELSDNLALMRLMTGSCPSCFYNLARVFCVMTCSPHQDTFQEVAEKQPEPG-KG-----LVTLNYYMSSAYAKGTFDSCYGLQFGGASVTKI--LCGSYADNCVPETLLMSLGAHDSLHSPFEIDFQFSDVP--VVSKNKTYVPMNDTFRKCSEPGAPGKEA-CSCSSCLDACSKI-VPVYPQDPKPWTIFRVDGFYIVAGIVFSIFLVIVLAVAV 238          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: gb|KFM60760.1| (Niemann-Pick C1 protein, partial [Stegodyphus mimosarum])

HSP 1 Score: 117.087 bits (292), Expect = 3.446e-28
Identity = 85/294 (28.91%), Postives = 143/294 (48.64%), Query Frame = 0

Query:   23 HCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMD-ASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIAS----HCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMG-TPSSIT-SPFKIDFKYSDDPPEIPHKFEYY--SPNTLTCDVPPPGESVPCSCTNCELSC--SQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQ 305
            HCV+ GICG++         +  C   G    +D     ++++  CP    E S+ +CC  EQI  LK   K+L++ A+     CP+C  N KK FC F C P+Q  FL V+    G +D+G+ +   + L YY +  +    +  CKD+   +   +++  +CGT    CTP++ LN+MG TP+    SPF+ID++ S +   +     +Y  + NT +C   P   +  C+C +CE +C  +            ++ +   DG+S++  +IF   T   L   +  K Q  +
Sbjct:   25 HCVMYGICGEN------DFGEATCAYNGTAKLLDDEEALEILQDICPDVLRE-SNVLCCDAEQIIHLK---KNLEIAATLGLGRCPSCITNFKKNFCQFACSPKQGDFLKVTA--LGKSDEGDII--IEKLTYYMSRRYAEEAFASCKDIQGLTPGSTVLDMMCGTWGRDCTPERWLNFMGSTPADDGFSPFEIDYQLSTENHLVIDGEHFYPMNENTTSCSESPYPGAEACTCLDCESACKLNIASPPPLPEEEELWTVMNHDGISVLCVIIFCFVTALLLLGFICFKMQSRK 304          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: EFX69947.1 (hypothetical protein DAPPUDRAFT_328579 [Daphnia pulex])

HSP 1 Score: 115.931 bits (289), Expect = 8.710e-28
Identity = 88/303 (29.04%), Postives = 140/303 (46.20%), Query Frame = 0

Query:   11 LLKSVETENVEGHCVLRGICGK-DPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQF-KSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFL--NVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYM--GTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKNQGNQIT 307
            L KS + E  +GHCV  G C   +         + + +       + +   +L ++  P  E     + CC   QI DL   F ++L+L+   CP+C  N++ +FC  TC P  S+FL  N + +   P        + K L+YY +  +V  +Y+ CK+V  PS +  +M  ICG     C+P++LL++M  G  +   SPF I F+Y  D   + H  E ++P  + C       S  CSC +C  SC            +   IG + G+S VM ++F   +  FL V V  K   +Q+ 
Sbjct:   90 LAKSSKDE--QGHCVWYGTCSDCEYAYNYAYSGEAMPIANTDHAALYSVCPELFEQFGPGEEP----HFCCDSRQINDLIVNFGQALNLVG-RCPSCARNLRMIFCTMTCDPHHSRFLSYNTTEEHSTPEPVTNSTVVVKALEYYISDTYVTEMYDSCKEVTNPSSNSLVMPTICGQWGEDCSPRRLLDFMGLGMANQGFSPFDIYFQYIPDGETVTHVVEPFAPPAIPCYEVISNSSGTCSCVDCTGSCPVPKPWPPLPEPWT--IGSMYGVSFVMLMVFLAVSGTFL-VTVFWKWHVDQVA 382          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: EFX76733.1 (hypothetical protein DAPPUDRAFT_321920 [Daphnia pulex])

HSP 1 Score: 112.849 bits (281), Expect = 8.703e-27
Identity = 80/283 (28.27%), Postives = 130/283 (45.94%), Query Frame = 0

Query:   17 TENVEGHCVLRGICGK-DPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQF-KSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFL--NVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYM--GTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL 293
            +++ +GHCV  G C   D         + + + +     + +   +L  +  P  E     + CC   QI DL   F ++L+L+   CP+C  N++ +FC  TC P  S+FL  N + +   P        + K L+YY +  +V  +Y+ CK+V  PS +  +M  ICG     C+P +LL++M  G  +   SPF I F+Y  D   +    E ++P  + C       S  CSC +C  SC            +   IG + G+S VM ++F   +  FL
Sbjct:   51 SKDEQGHCVWYGTCSDCDYAYNYAYSGEAMPIADTDHAALYSVCPELFDQFGPGEEP----HFCCDSRQINDLIVNFGQALNLVG-RCPSCARNLRMIFCTMTCDPHHSRFLSYNTTEEHSTPEPVTNSTVVVKALEYYISDTYVTEMYDSCKEVTNPSSNSLVMPTICGQWGEDCSPHRLLDFMGLGMANQGFSPFDIYFQYIPDGETVTDVVEPFAPPAIPCYEAISNTSGACSCVDCTGSCPVPKPWPPLPEPWT--IGSMYGVSFVMLMVFLAVSGTFL 326          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: EEB17553.1 (Niemann-Pick C1 protein precursor, putative [Pediculus humanus corporis])

HSP 1 Score: 108.612 bits (270), Expect = 2.885e-25
Identity = 74/287 (25.78%), Postives = 126/287 (43.90%), Query Frame = 0

Query:   26 LRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPH-FESEISSNI---CCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLN-VSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV----QQKNQG 303
            + G CGK       ++  L C   G    +     K++KK CPH F+S   S +   CC + Q+  L    +   ++ S CP+C YN  + +CDFTC P+QS F+  + +     N           +  Y N  +    Y+ CK+V  P  +   M  +C      C+P+    ++G  S+  SP++I++  S    E    F   +  T +C+  P      CSC +C  SC         +    F++G + G   VM ++F   ++ FL +++    + + QG
Sbjct:    1 MYGECGKAQNAPAAQL--LPCSYNGTAKVLSDKGIKVLKKWCPHYFDSTSDSQLIYTCCDEAQLETLDKNIQQAMMLISRCPSCKYNFVRHYCDFTCRPDQSNFIEPLRIVNATLNKSAGYRPAVSEINLYINKSYTYGTYDSCKNVYLPLANQYAMDLLCNRPVVSCSPELWFEFLGDASAF-SPYQINYIMSSKAKE--KNFTPLNIKTYSCNEAPLENESACSCVDCVESCPIPP--PVPSPVAPFFVGALPGRDFVMLLVFIAGSLIFLSIVLFCNKRNRQQG 280          

BLAST of EMLSAG00000002936 vs. Select Arthropod Genomes
Match: AHN54311.1 (Niemann-Pick type C-1a, isoform G [Drosophila melanogaster])

HSP 1 Score: 107.842 bits (268), Expect = 4.806e-25
Identity = 79/307 (25.73%), Postives = 131/307 (42.67%), Query Frame = 0

Query:    8 VFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL---FVLVQQKN---QGNQIT 307
            +F L++S + +     CV  G+C  +        P       G   EM     +L+KK C        +  CC K Q+  L    +    I   CP+C  N+ +  C FTC P+Q++F++V       N KG+  E    +  + + +++N  Y  C  V  P         +CG  + + C P K  N+MG  ++   PF+I +    +P    + F   +  T+ C+     +   CSC++C+LSC Q            F I G+D   ++M  +F V  + FL   F+  Q  N    GN ++
Sbjct:   22 LFTLIQSSKQD-----CVWYGVCNTNDFSHSQNCPY-----NGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVAT--QKNKKGD--EYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITY-IQHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQ--GPPEPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLMGSFLFTQDDNFQVDGNDVS 311          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|225719564|gb|ACO15628.1| (Niemann-Pick C1 protein precursor [Caligus clemensi])

HSP 1 Score: 369.007 bits (946), Expect = 3.675e-125
Identity = 184/304 (60.53%), Postives = 218/304 (71.71%), Query Frame = 0

Query:    5 MLF--VFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEIS-SNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHK---FEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKY-QTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQKN 301
            MLF   FIL           HCVLRGICGKDPTVT+GK+P LLC DEGPP EM   LK+ M+K CPHFE+EIS S ICCT+ QI DL+S F SL+ +A HCPTC YN+KKVFCDFTCHPEQS+FLN S KIWG N +GEEVEM K L YY +  F N VYN CKDVLFPSQS SI+ FICGT    C+PKKLL YMGTPSS+TSPF I F +S+D   +       EYY+P TL C+VPPPG   PCSCTNCELSC  +DF  Y + +  +F+IG +DGL++VMG IF  F++ F+ VL+  + 
Sbjct:    1 MLFGIAFILAFQQIALGSSHHCVLRGICGKDPTVTIGKVPMLLCADEGPPNEMPEKLKRRMRKVCPHFETEISASKICCTRRQIIDLESNFASLEAVAGHCPTCLYNLKKVFCDFTCHPEQSRFLNASKKIWGKNSEGEEVEMVKELDYYVDSIFSNEVYNACKDVLFPSQSSSILPFICGTP--FCSPKKLLEYMGTPSSVTSPFLIQFFHSEDDDHVNSSSAGLEYYNPRTLPCNVPPPGALNPCSCTNCELSCPSLDFSIYPRQTGVLFHIGELDGLTVVMGAIFIAFSIGFIAVLLFMRR 302          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|225709052|gb|ACO10372.1| (Niemann-Pick C1 protein precursor [Caligus rogercresseyi])

HSP 1 Score: 327.02 bits (837), Expect = 1.117e-108
Identity = 157/302 (51.99%), Postives = 207/302 (68.54%), Query Frame = 0

Query:    1 MLVPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQ--TSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQK 300
            +L P+LF+ IL   V+  + EGHCVLR +CG+DPT+  G    LLC D GPP EM   LKKLM K CPHFE EISS ICCT+ QI+DL+    +L  +  HCP+C Y+++++FCD TCHPEQS FL+ +VK+WG N KGEEVEM K L YY +  F N +Y  CK+VLFPSQS+S++ F+CGTA  LC+P+KLL YMGT S +TSPF+I+F  S DP    +  + Y P T  C+  P  ++  CS  NCELSC  +DF  Y+  +++F+F IGG DGL IVM  IF +F++ F+  L+  K
Sbjct:    2 LLNPVLFLSILAYLVDFTSGEGHCVLRDVCGRDPTLPAGTNINLLCTDSGPPNEMKEKLKKLMAKVCPHFEPEISSKICCTRRQIKDLQMNMLTLRAVVGHCPSCFYDIRRLFCDLTCHPEQSNFLHAAVKVWGENPKGEEVEMVKELNYYLSPTFFNVIYEACKNVLFPSQSMSVLPFLCGTA--LCSPEKLLKYMGTQSRVTSPFQINFIPSKDPIVEENNLQLYDPPTFPCNAAPSTDTDVCSSANCELSCPTLDFSVYKGPSTNFLFTIGGTDGLVIVMASIFVLFSIGFIGTLIYGK 301          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|926627137|ref|XP_013779130.1| (PREDICTED: Niemann-Pick C1 protein-like, partial [Limulus polyphemus])

HSP 1 Score: 140.584 bits (353), Expect = 9.137e-35
Identity = 97/304 (31.91%), Postives = 151/304 (49.67%), Query Frame = 0

Query:    3 VPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGP--PTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKS-LDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSP---NTLTCD--VPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIF--SVFTVAFLFVL 296
            V ++ ++ L++ ++ E   G CV+   CG DP VT  K P   C    P  P   + S+K L +     F+++  S +CC + Q+  L  Q K  L L+   CP+C  N+  +FC  TC P+QS F+ V+      N+  +  EM   + YY    F   +Y  C++V  PS +I  +  +CG     CTP+  L +MGT     SPF+I+FKY + P  + +  + Y P   + + C   V P GE+  CSC +C  SC    F  +      +++ GI G+ +VM  +F  +V  V   FVL
Sbjct:   13 VLIILIYFLMRILQVEGETGQCVMNTECGVDP-VTNLKAP---CASSVPAKPLRNETSVKLLHQLCGKAFKTDFDSPVCCDEYQLSSLGDQLKGPLALLLQRCPSCFTNLANLFCMMTCSPDQSSFIQVT----KTNETSQGKEMVTEISYYITDAFSVGLYANCENVQLPSGNIRAIIVLCGKWGDKCTPRHWLEFMGTHDP--SPFQINFKYYEGPVHVGN--QTYLPMDTHIIPCSQAVTPRGEA--CSCVDCPASCDTPMFPTFPPPPLEWHVWGIPGMWVVMSFVFIATVIAVVIGFVL 302          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|548422487|ref|XP_005742626.1| (PREDICTED: Niemann-Pick C1 protein [Pundamilia nyererei])

HSP 1 Score: 140.969 bits (354), Expect = 1.008e-33
Identity = 94/302 (31.13%), Postives = 141/302 (46.69%), Query Frame = 0

Query:    2 LVPMLFVFILLKS--VETENVEGH-CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSP---NTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
             + +LF+ I L      + +V  H CV  G CG  P    GK  K  C   GPP  +      L+ + CP ++   + ++CC  +Q+R LK   +      S CP C YN+  +FC+ TC P QS+F+NV+      N  GE V     +QYY    F N++YN CKDV  PS ++  +  +CG     C     + +M    +  +PF ID K++D P         Y+P   NT  C+      S PCSC +C  SC            +   I GID ++++M + +  F + F  VL+
Sbjct:    9 FLSLLFLVIFLAEGYFRSYHVAAHHCVWYGECGNSPVP--GK--KYNCNYTGPPKPLPPDGHLLLTELCPGYDYG-NKSLCCNVDQLRTLKGSLQLPLQFLSRCPACFYNLMNLFCELTCSPHQSQFMNVT------NITGENV---MAVQYYIGQTFSNAMYNACKDVQAPSSNVKALSLLCGKTAEACNATNWIQFMFNTENKQTPFPIDPKFTDVP------LAGYTPMNNNTYACNESLEDGSGPCSCQDCAKSCGPKPVPPPLPPPWT--ILGIDAMAVIMWISYMAFLLIFFGVLL 288          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|498945986|ref|XP_004542931.1| (PREDICTED: Niemann-Pick C1 protein [Maylandia zebra])

HSP 1 Score: 139.428 bits (350), Expect = 3.618e-33
Identity = 93/302 (30.79%), Postives = 142/302 (47.02%), Query Frame = 0

Query:    2 LVPMLFVFILLKS--VETENVEGH-CVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSP---NTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
             + +LF+ I L      + +V  H CV  G CG  P    GK  K  C   GPP  +      L+ + CP ++   + ++CC  +Q+R LK   +      S CP C YN+  +FC+ TC P QS+F+NV+      N  G++V     +QYY    F N++YN CKDV  PS ++  +  +CG     C     + +M    +  +PF ID K++D P         Y+P   NT  C+      S PCSC +C  SC            +   I GID ++++M + +  F + F  VL+
Sbjct:    9 FLSLLFLVIFLAEGYFRSYHVAAHHCVWYGECGNSPVP--GK--KYNCNYTGPPKPLPPDGYLLLTELCPGYDYG-NKSLCCNVDQLRTLKGSLQLPLQFLSRCPACFYNLMNLFCELTCSPHQSQFMNVT------NITGKDV---MAVQYYIGQTFSNAMYNACKDVQAPSSNVKALSLLCGKTAEACNATNWIQFMFNTENKQTPFPIDPKFTDVP------LAGYTPMNNNTYACNESLEDGSGPCSCQDCAKSCGPKPVPPLLPPPWT--ILGIDAMAVIMWISYMAFLLIFFGVLL 288          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|348500675|ref|XP_003437898.1| (PREDICTED: Niemann-Pick C1 protein [Oreochromis niloticus])

HSP 1 Score: 137.887 bits (346), Expect = 1.157e-32
Identity = 90/302 (29.80%), Postives = 143/302 (47.35%), Query Frame = 0

Query:    2 LVPMLFVFILLKSVETEN---VEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSP---NTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
             + +LF+ I L      +   V  HCV  G CG+  +   GK  K  C   GPP  +     +L+ + CP ++   + ++CC  +Q+R LK   +      S CP C YN+  +FC+ TC P QS+F+NV+      N  G +V   + ++YY    F N++YN CKDV  PS ++  +  +CG     C     + YM +  +  +PF I+  ++D P         Y+P   NT  C+      S PCSC +C  SC            +   I GID ++++M + +  F + F  VL+
Sbjct:    9 FLSLLFLVIFLAEGYFRSYHVVAHHCVWYGECGE--STVAGK--KYNCNYTGPPMPLQPDGYQLLTELCPGYDYG-NKSLCCNADQLRTLKGSLQLPLQFLSRCPACFYNLMNLFCELTCSPHQSQFMNVT------NITGVDV---RAVEYYIGQTFSNAMYNACKDVQAPSSNVKALSLLCGKTAKECNATNWIQYMFSTKNGQAPFPIEPVFTDVP------LAGYTPMNNNTYACNESLDDGSGPCSCQDCTKSCGPKPVPPPLPPPWT--ILGIDAMAVIMWLSYMAFLLIFFGVLL 288          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|583994067|ref|XP_006792181.1| (PREDICTED: niemann-Pick C1 protein-like [Neolamprologus brichardi])

HSP 1 Score: 136.346 bits (342), Expect = 4.149e-32
Identity = 90/302 (29.80%), Postives = 141/302 (46.69%), Query Frame = 0

Query:    2 LVPMLFVFILLKSVETEN---VEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSP---NTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
             + +LF+ I L      +   V  HCV  G CG   +   GK  K  C   G P  +     +L+ + CP ++   + ++CC  +Q+R LK   +      S CP C YN+  +FC+ TC P QS+F+NV+      N  GE+V     +QYY    F N++YN CKDV  PS ++  +  +CG     C     + +M   ++  +PF ID  ++D P         Y+P   NT  C+      S PCSC +C  SC            +   I G+D ++++M + +  F + F  VL+
Sbjct:    9 FLSLLFLVIFLAEGYFRSYHVVAHHCVWYGECGN--STVAGK--KYNCNYTGLPKPLPPDGHQLLTELCPGYDYG-NKSLCCNVDQLRTLKGSLQLPLQFLSRCPACFYNLMNLFCELTCSPHQSQFMNVT------NITGEDV---MAVQYYIGQTFSNAMYNACKDVQAPSSNVKALSLLCGKTAKACNATNWIQFMFNTNNQQTPFPIDPVFTDVP------LAGYTPMNNNTYACNESLDDGSGPCSCQDCAKSCGPKPVPPPLPPPWT--ILGVDAMAVIMWISYMAFLLIFFGVLL 288          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|1049269933|ref|XP_017575164.1| (PREDICTED: Niemann-Pick C1-like protein 1 [Pygocentrus nattereri])

HSP 1 Score: 135.576 bits (340), Expect = 7.288e-32
Identity = 85/289 (29.41%), Postives = 143/289 (49.48%), Query Frame = 0

Query:   16 ETENVEGHCVLRGICGKDPTVTVGKIPKLL-CVDEGPPTEMDASLKKLMKKACPHF-ESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPE----IPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
            + ++  G C++   CGK+PTV+   +   + C + GP  E+  +  +L K+ CP   + E  +  CC+ +Q+  L+S       I   CP+C YN   + C  TC P QS+ +N++  I   N  G E +     Q Y +  F ++ +N CK+V  P+     +G +CG    TLCTP++ L++ G  S+  +P  IDF+    PPE    +P     Y+   L C+   P     CSC +C+ SC  +         F+  IG ++G   +  ++F++F + FL  +V
Sbjct:   26 DAQHEAGFCLMYEECGKNPTVSGSLLESNVPCKNPGPAREVVGAHYELFKEVCPMLDQGEGQTFACCSPQQLISLQSSVSLSKAILLRCPSCAYNFAHIHCITTCSPNQSQTINITRTI-PVNISGTEKDAVVSYQAYVSTTFSDASFNSCKNVRIPATGGYAIGTMCGRYGSTLCTPQRWLDFQGDSSNGLAPLDIDFRLI--PPEHNAAVPEGMVPYAGIALGCNETTPTGGEECSCQDCQESCPPVPPPGPLPEPFM--IGNMEGFLAISLILFAIFCLLFLIFIV 309          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|913317361|ref|XP_013189663.1| (PREDICTED: Niemann-Pick C1 protein-like, partial [Amyelois transitella])

HSP 1 Score: 133.65 bits (335), Expect = 2.327e-31
Identity = 90/306 (29.41%), Postives = 152/306 (49.67%), Query Frame = 0

Query:    2 LVPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGT-APTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPE--IPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFL---FVLVQQKN 301
            +V  L +  L + V T + EGHC+  G+C         +  K+ C  +GP   ++ S + +++K CP   +      CC  +Q+ +L +     + I + CPTC  N  K  C  TC P QS+F+   VK+ GP +   +  +   + Y+ +  ++ S YN C  V  P+ +   M F+CG+ +   C+P++  + MG  SS   PF+I++   ++P +  IP+     +P T  C+V   G+   CSC +C  SC        + +   F I G DG ++VM ++F +FT  FL   +   QQ+N
Sbjct:   14 VVGCLLLIHLAEYVPTASAEGHCIWYGVC-----TNATQTKKVNCYYDGPAKPIEESTRSIIQKYCPDIAA--GGLACCNSDQLINLNNNIGMAENILARCPTCMENFIKHICGLTCAPNQSEFIK-PVKL-GPYNTTHKQILE--IDYHLSTTYMESTYNSCSQVQVPASNQLAMDFMCGSWSAAYCSPQRWFDSMGDASSAFVPFQINYISGNEPVDGMIPN-----NPPTRPCNVGSNGQP-GCSCLDCAASCPAPP--PPRPAPRPFSIHGADGYAVVMAIVFVIFTTLFLSGVYCCNQQEN 300          

BLAST of EMLSAG00000002936 vs. nr
Match: gi|512846966|ref|XP_004915269.1| (PREDICTED: Niemann-Pick C1 protein [Xenopus tropicalis])

HSP 1 Score: 134.035 bits (336), Expect = 2.420e-31
Identity = 86/300 (28.67%), Postives = 139/300 (46.33%), Query Frame = 0

Query:    2 LVPMLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVK--IWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDP--PEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLV 297
            L+P+ F+  L       +   HCV  G CG        +  +L C   GPP  +      L+++ CP      ++ +CC  +Q+  L S  +      S CP+C YN   +FC+ TC P QS+FLNV+      GP+ +    E    ++YY    F N++YN CKDV  PS ++  +  +CG     C     + YM +  +   PF I   +SDDP    +P      +  T  CD P       CSC +C LSC  +         ++ +  G+D ++++M +++ VF + F  V++
Sbjct:    9 LIPLFFLITLWLPGRVSS--QHCVWYGECGNSTL----EDKRLNCRYSGPPISLPEEGHTLLQQLCPSLYYG-NNTVCCDVQQLNTLNSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPYQSEFLNVTQTEPFVGPSPQRAN-ESIVAMEYYIGEQFANAMYNACKDVEAPSSNVKALALLCGKDVKDCNATNWIQYMFSKDNGQVPFTITPIFSDDPVTSMLPM-----NNATKGCDEPVEEGGASCSCQDCALSCGPVPQPPPLPPPWLIF--GLDAMAVIMWIVYVVFLLLFSAVII 293          

BLAST of EMLSAG00000002936 vs. Tigriopus kingsejongenis genes
Match: maker-scaffold609_size125094-snap-gene-0.22 (protein:Tk01016 transcript:maker-scaffold609_size125094-snap-gene-0.22-mRNA-1 annotation:"niemann-pick c1 isoform x7")

HSP 1 Score: 156.762 bits (395), Expect = 6.651e-43
Identity = 98/287 (34.15%), Postives = 153/287 (53.31%), Query Frame = 0

Query:   23 HCVLRGICG-KDPTVTVGKIPKLLCVDEGPPTEMD--ASLKKLMKKACPHFESEIS-----SNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICG-TAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGKYQTSSFIFYIGGIDGLSIVMGVIFSVFTVAFLFVLVQQK 300
            HC+  G    ++P+     +P     D  P   M+   +L KL + ACPHF  ++       ++CC  +QI DL + F   + +   CP+C  N +K FCD TC P+QS FLNVS  I   N  G EVE+   L YY + ++    Y+ CKDV+ P+ S   M  +CG      C+P++  +YMG+ S+  SPF I F  SD+  E    FE ++P  + C+    G+   CSCT+C  +C+ + F   +  + +F +G +DG++ +M +IF + TV FL ++   K
Sbjct:  619 HCIWWGTSPFENPSFAGRYLPYH---DSNPARHMEPGETLNKL-QLACPHFSEDLGPPENGWDVCCAPDQIEDLVTNFVLPESVLDRCPSCLDNFRKNFCDLTCRPDQSSFLNVSGIITQTNATGTEVELVVELTYYISKEYNEKTYDSCKDVINPATSGPAMSLLCGPWGAEKCSPQRWFDYMGSTSNGYSPFDILFVISDE--ETLDGFEMHNPTVVPCNESSMGKP-QCSCTDCLDTCTPVVF---EEPTELFKVGKLDGVAFIMILIFILGTVLFLALVFTNK 895          

BLAST of EMLSAG00000002936 vs. Tigriopus kingsejongenis genes
Match: maker-scaffold22_size673200-snap-gene-4.23 (protein:Tk12689 transcript:maker-scaffold22_size673200-snap-gene-4.23-mRNA-1 annotation:"niemann-pick c1 protein isoform x3")

HSP 1 Score: 155.606 bits (392), Expect = 1.519e-42
Identity = 77/257 (29.96%), Postives = 138/257 (53.70%), Query Frame = 0

Query:    5 MLFVFILLKSVETENVEGHCVLRGICGKDPTVTVGKIPKLLCVDEGPPTEMDASLKKLMKKACPHFESEISSNICCTKEQIRDLKSQFKSLDLIASHCPTCTYNMKKVFCDFTCHPEQSKFLNVSVKIWGPNDKGEEVEMAKVLQYYANIDFVNSVYNGCKDVLFPSQSISIMGFICGTAPTLCTPKKLLNYMGTPSSITSPFKIDFKYSDDPPEIPHKFEYYSPNTLTCDVPPPGESVPCSCTNCELSCSQIDFGK 261
            ++ +F +L       + G C+    CG DP    G    L C  +G P  + A ++ ++ + CP++E+  +   CC+  Q++++ + F  +  +   CP+C +N KK FCD +C P+QS F+ V+  +       E + +   + ++ + +F   VY+ CKDV+ PS S S++  +CG+  +LCT ++   Y+G P++  +P +I+F    +P     K   Y+ +T+ CD  PP     CSCT+CE +C   DFG+
Sbjct:    4 IIVLFYVLARALPVALGGQCLWYDECGIDP----GTGKNLNCQYDGLPKPLPADIRVVLDEHCPYYEN--TELFCCSPTQVQNMVNGFGVIASLLGRCPSCLHNFKKAFCDMSCSPDQSDFMKVTKTVEVRGYDNESISLVHEVDFHLDKEFGIQVYDSCKDVVNPSTSGSVLELMCGSWGSLCTAQRFFTYLGNPANQNTPIRINFYLESEPHHEGGKL--YNRSTIHCDEAPPNGDGACSCTDCERACQSPDFGQ 252