Query:   16 LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCS-HLLEEECSLFEKHRNTQKLKSASNW--------------------IAILRVILRTDELSIPWKKL---EDHSNNNYRMKFYKDYIANDLKKVH-----HEANESEVLKIASILDSNSFRI----NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL----WNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEG 379
             EI   +  GR L A  +I     I KE+P V+GP +   +  +C+ C   +  L     + +   CS+CS  L  +EC     H+   +L S SN+                    I +LR +   D+    + KL   EDH         Y+   AN +  +       +  E ++L+IA+ILD+N+F +     +  +R L+  ++ I+HDC PN R  FD   ++  ++K+ I KGE +SISY  PL ST +RR  L  +K F C C RC DP ELGS   +  C KC+ G+I+  N +L    W C  C F+   + V      + ++LE+ + ++   L++ I      L ++++ +L+ K  L            + ++ E +++KL +  + L +  I +G
Sbjct:   49 FEIATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVA--SAPLCLGCHRNL--LAPGKPRGNYHKCSSCSWPLCGKECEDSVHHKAECQLMSGSNFQSKINYVPGEEERKESAYCVIMLLRCMHLKDKDPDAFLKLYNLEDHLKERLETPLYQVLRANLITFIKTVLGMKDWPEMDILRIAAILDTNTFEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRKIAKGEILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCLKCKAGKIISLNPLLNSAPWKCQLCNFKRSAKDVVTSDAELQQELESLDKTTPVALEEFIYRHRADLHETNTHILQAKYALTQLYGSAPGFAMEELSGESLNRKLQLCEELLKLADIFDG 453          

Query:   15 KLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSV-EMCSNCSHLLEEECS-LFEKHRNTQKL-----KSASNWIAILR-VILRTDELSIP--------------------WKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINK----HSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQ--KGRIVQTNDI-LWNCIECGFET-QDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSI-------TLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYEL---LMGKIYLTSKSSA 409
            K EIK     GR   A   +     +  E+P VV  P++GE R     CS   +  E+FCRKC +  +C +CS   E +C  L E + +  ++     K  +    +L+ ++LR  E ++P                    WK  ++H+          DY    L ++   A+E  V  +  ILD N++ I       ++RGL+  +    H C PN  +  D +  + + + + I  GE +   Y   LL T ERR+ L   K F C C RC DPTELG+H+SS +C +C    G IV+  D  +W C+     T + E V+N+L+   +++ +    I   +  +    + L ++H +ML+ K+ +    R+ +         +V ++K+ +  + L +L ++     SRLK    Y++      L  K+Y   + SA
Sbjct:   11 KCEIKQNDTLGRFAVALCNVRAGETLLLENPIVV-LPLMGERR-----CSKCFNLTESFCRKCRLLALCEDCSDHDERDCKRLAEMNFSDDQVELLQKKEHTEIQPVLKCLLLREHEETLPLYEEMSQMDSQLMTRRGTEVWKNYQEHAFTPL------DY-GGVLAQLRGAADEDLVQGLLGILDINAYEIRAPEVGGAMRGLYRRAGLFAHSCTPNLVISIDDEQRIKVYANRFIAAGEILYNCYTNVLLGTEERRKILKVGKCFDCSCPRCQDPTELGTHMSSFICSQCSCVDGYIVRQPDTGIWQCLLNPEHTLKQEFVSNMLERAKEEIFHARDDIYRQELLLAKLSRLLHRNHFLMLDLKQNIASILRQILQNMGTRPNKKVYERKIRLCQEILLVLKVVTPGI-SRLKAIALYELANTQAELARKMYTEMEHSA 437          

Query:    8 NLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCR-KCSVEMCSNCSHLLEE--ECSLFEK--HRNTQKLKSASNWIAILRVI--LRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANE----SEVLKIASILDSNSF----RINKHS--LRGLFGVSSFINHDCNPNARVIFDRKGHLHLI-SKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPK--CQKGRI-VQTNDIL--WNCIECGFETQDEKVNNLLQFIVKKLEN--NSSSIDTLDKTIKSFEKKL-PQSHSIMLEYKKRLIDQQRKSITLEVIDQKL-HILSQRLDILHILE--GDCDSRLKGFLSYQI 393
            +L ++     I ++   GRG+FA  +I+   +I++E   V GP       + CI C  T+      CR +C++ +C  CS   E   EC  F +   ++    +   N ++ LR++  +R   L    + L D    N    + ++ I       +    +     ++ +I  +L++N+F    R   H   LRGLF +++ +NH+C PNA   F+  G L ++ + + I KG EI+ +Y   L     R   L  +K F C C RCHD TE G++LS+L C +  C+   I VQT  +   W CI C       K+     F +  + N  NS S+  +   I     +  P S+ +++E K  +I +  +    E   +++ H+   R ++L IL   G  +  LK  ++ +I
Sbjct:   49 DLRQEQPNWTISSSTVAGRGVFATRDIAAGELIFQERALVTGPTARKGQLSSCICCHETLPQTGFLCRHRCTLPVCETCSDSEEHQAECEHFRRWQPKDVDAEQEQVNPMS-LRILTAVRVFHLGKEQRHLVDAMQANAERAYRREIIQAAQCFRNFPTTDRVFMDQLFRIVGVLNTNAFEAPCRSGGHETLLRGLFPLTAIMNHECTPNASHYFE-NGRLAVVRAARDIPKGGEITTTYTKILWGNLTRNIFLKMTKHFACDCVRCHDNTENGTYLSALFCREQGCRGLVIPVQTRTLQPDWRCITCENVFPHAKMAKYQDFALNTINNRINSCSVQDMIHFINELCPRFCPSSNYVLIEAKLNVIWRMTRFDHEEYTPEEMGHMDRYREEVLAILHKLGAGECTLKKLITGEI 461          

Query:   11 EKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLEN--FCRKCSVEMC-SNCSHL------LEEECSLFEKHR-----------NTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHS----NNNYRMKFYKDYIANDLKKVHH--EANESEVLKIASILDSNSFRI--NKHSLRGLFGVSSFINHDCNPNARVIFDRKG-HLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRI------VQTNDILWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKS-------ITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRIL 433
            EK     ++ +   GR L A  ++     + +E P  +GP + G+   VC+ C + +    +   C  C+  +C S C+ L       E EC L+ + R              +++     + I+R++L      E      ++E H+     N    + Y++ +   L+      +    +V ++  ILD N F I  N    R L+  +  + HDC PN     D     + L + + + + E +++SY   L  T +RR  +   K F+C C+RC DP ELG+  S+L+C  C+ G +       QT D  W C  C  +    +V   L  I   LE+ +   I  L+  +  +   L  +H ++L  K  L     ++       ++ E I +K     + L+I+ +L+    +RL+G + Y+++  +M       +S  +   + Q+   +++K + V++ IL
Sbjct:   44 EKELPYRVEHSDIYGRYLVANRQLEAGETLIREEPLAIGPCVSGD--PVCLGCYHPVSLKADQYRCPGCAWPLCGSTCAGLKHRHGHTETECQLYAERRAVAGELLTERAGPAEVRDLYELVMIVRILLLRQHDPEQFALIARMESHTEERRQNAVLWRHYEEKVVQRLRVTWQLEDLEAEQVHEVCGILDVNCFEIGQNGAKARTLYPSAFLLAHDCTPNTAHTDDPSSFEILLRTSRRVREREALTLSYAYTLQGTLKRRAFMHEGKLFWCCCRRCSDPRELGTDCSALVCATCRTGSVRAVDPLQQTGD--WACDRCAHKMGATEVERQLDRINNDLEDIDVHDIPGLENFLLRYRDVLRPNHYLLLSAKYSLCQIYGRTEGYLLPQMSPEDIARKESYCREFLEIVDVLDPGL-TRLRGLIMYELHAPVMVLAQSAFQSGQISRQEFQRRLKEVVKLLQVSRDIL 507          

Query:    9 LYEKSC-KLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF-CRKCSVEMCS-NCSHLLEE--ECSLFE---KHRNTQKLKSAS---NWIAILRVILRTDELSIPWKKLED--------HSNNNYRMKFYK--DYIANDLKKVHHEANESEVLKIASILDSNSFRI--NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQ-KGRIVQTNDILWN----CIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYK---KRLIDQQRKSITLEVIDQKLHILSQRLDILHILE--GDCDSRLKGFLSYQIY 394
            +++ SC   +I   +  GR L A   I    ++ KE+P V GP  I  +  VC+ C N I   ++  C +C   +C   C  L E   EC L +   +  N Q+          ++ +R +L  +  +    K +D          +N ++        +I    K    +  E E++K    L  N   +     S   +F  +SF  + C PN    F++ GH  L + + I+K   +SI Y   +  T +R+  LM +K F C C+RC D TEL ++ S++ C   Q  G ++ T    WN    C EC  + Q   V  +L+   K +++     +   K +K +EK LP  H  M E K    +L+ + +K + +   D+ L  L+   +++ + E    C+ R  G L ++++
Sbjct:   35 VHKPSCHPFKIAHNEQLGRHLVATRTIKPYEIVLKEAPLVRGPAQI--SAPVCLGCLNGIEAEDHIECEQCGWPLCGPECKSLDEHKAECGLTKDRGQKVNVQEFGGPHPLYTCLSTVRCLLIGETSTEKASKFQDLESLESTRRGSNQWKADLVSIGQFIPKFFKT--QKFTEEEIMKAVGALQINGHEVPTTDPSHVAVFYTASFTENSCLPNLAKSFNKNGHCILWAPREIKKNAHLSICYSDAMWGTADRQRHLMQTKLFKCACERCVDVTELDTNYSAIKCEDRQCGGLMLPTKADEWNGSWRCRECHKQVQKHYVERILERAGKDIQSMEKIAENGLKYLKHYEKWLPPQHFHMSEIKILLVQLLAKDQKELMVIPDDRLLLKLNFARELVELYEKLTPCEVRTLGTLCFELH 449          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVC--ITCSNTIHYLENFCRKCSV-EMCSNCSHLLEEECSLFEKHRNTQKLKS--ASNWIAILRVILRTDELSIPWKK------------LEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASI-----------LDSNSFRI---NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRI--VQTNDIL--WNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKL-HILSQRLDILHILEGDCDSRLKGF 388
            GR L A   I     I +E P +V P         C  + C+  +      CR+C V  +C +C+   E EC  F         K     N+  I  ++     L  P  K            L D+ +     + +++ +   L     E+  ++VL    +           +DSNSF +   +  +L+G+F   + + H C PN  V  D + ++ L +   ++ G+ I  SY  PL+ T +R+ +L  S+   C C RC DPTE+G+H+SSL C +C    +  + +N  L  W C +C       +V+ L   +   L +    +   +  +  +   L  +H ++L+ K+ +    R +  +  +DQ    +L++R+++   L   C + + G 
Sbjct:   17 GRHLVASIAIEPGDTILEERPLLVAP------HWECHQLKCAQCLQESYVICRRCQVFPLCMDCNQHDEFECEFFTSGAGKALCKDILVKNF-GICGLLKLLLLLENPRTKGDCQMLIDVPINLSDYRDGEGMWQEHEELVVRPLM----ESGLADVLPTQELTSDALHAHCIRIDSNSFEVTAKDGDTLKGIFVWGATLPHHCVPNTVVALDEQFNMKLYAAVPLQPGDIIYNSYTNPLMGTSQRQHQLRLSRRLECICSRCLDPTEMGTHMSSLKCKECPGFSVCEIDSNGKLGDWRCPDCRALLTAAEVHELQAAVGSALVDAMGDLQVYEALLTQYGPLLHPNHFMLLDIKQNIASILRAAALMNSMDQPCKKLLARRVELCSDLLPVCRAVVPGI 405          

Query:   11 EKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENR-TVCITCSNTIHYLENFCRK-CSVEMCSNCSHLLE--EECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKL----EDHSNNNYR------MKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKH---SLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKT-IEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQ-KGRIVQTNDIL----WNCIECGFETQDEKVNNLLQFIVKKLEN--NSSSIDTLDKTI-KSFEKKLPQSHSIMLEYKKRLIDQ 350
            +K    EI  +K  GRG+ A   + +  +I+++SP ++G     E+    C  C   +      CR+ C + +CS C+   +   +C LF K     +   A++ +  L  + R   LS   + L    + + +NN+R       K +K++  +  KK+    N +  +   +  D  + R N +   + R L+ +   +NHDC PNA   F+ K +  ++     I +G E++ +Y         R   L   K F C+C RC DPTE G+ +S L C      G +V     L    WNC+ C  ++   ++     F    +    NS+S+ TL + + +  +  +P S+ ++++ K  ++ +
Sbjct:   20 DKDPAWEIGVSKIAGRGVVATRSLKRGEIIFRDSPLLIGLAAHEEDSLNACSVCLKMLPDTRFMCRQGCGLPVCSLCAKKKQHKSDCDLF-KSWGPNEPDVANSVVIRLLCVARAINLSKEQRDLIYCLQANLDNNHRTEVRNAAKCFKNFPTD--KKLIEIMNRTVAVLRTNGFDKTTDRTNDNQEFNYRALYPLFGVVNHDCIPNAYYTFEEKTNNMIVRAAVDIPEGFEVTTTYTKLFTGNIARHLFLKMKKSFTCKCSRCSDPTEKGAFISGLYCRDTNCAGLVVPEITGLPHPNWNCLVCKQKSTHAQMMKSQDFASGAINAKVNSNSLRTLVQYLNEKSDSFIPSSNYVVIDAKMSVLQR 382          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPII------GENRTVCITCSNTIHYLENFCRKCSVEMCS-NCSHLLEEECSLFEKHRNT-------------------------QKLKSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHH----EANESEVLKIASILDSNSFRINKHS---LRGLFGVSSFINHDCNPNARVIFDRKGH-LHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQT------------NDILWNCIECGFETQDEKVNNLLQFIVKKLEN 314
            GR L     I+   +++ E P VVGP           +   C+ C       ++ CR+C   +CS  C H    ECS+      +                          + +S + W A+L   +++ E       L + +         K ++   LK+ +     +     + ++  I+++N   I   S   L GLF  +  + H C PN    FD K   + + +   + KG+ + I+Y   L  T+ R+  L  +K F C+C RC DPTE G+++S+L C     G + QT             +  W C  C        V  L   + +++E 
Sbjct:   55 GRYLKVTQNIAAGQIVFIEEPLVVGPKWYLSDADKEASNVPCVGCYTPCRLGKHQCRRCRWPVCSAGCKHE-SMECSVLSLGSGSPTRADARSLNDYFRGDALLVLKCLLLQRQSPTKWSALLE--MQSHEEERKGTDLYEEAEKRVVTYLQKRFLCR-LKQTNPNLLTDCGPEMLHRLCGIIETNFMVIELPSGVELSGLFRQACMMEHACQPNCDFQFDNKTQQVAVRAGCDLRKGDHLRITYTNILWGTQLRQHHLRLTKHFSCRCSRCLDPTEYGTYISALTC----LGDVNQTCGGTHLPVDPLDENTQWKCDTCPMIVDGAYVAELQSHMTEQVEG 388          

Query:   20 AAKDRGRGLFACHEISK-DTVIYKESPFVVGPPIIGENR--TVCITCSNTIHYLENFCRKCSVEMCSNCSHLLE----------------EECSLFEKHRNTQKLKSASNWIAILRVILRTD--------ELSIPWKKLEDHSNNNY-RMKFYKDYIANDLKKVHH----EANESEVLKIASILDSNSFRINKHSLRGLF--GVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRC 256
            A+   GRGLFA  +I   D +++ + PFV    ++   R    C  C    H+     ++ S++ C+ C H+++                 EC +F   RN +      N  A+LR++LRT+        E  + ++ LE H ++   R     + IA   + V      +  E +++   + LD NSF +      G++    ++ INH C+ NA V FD    + + + + I  GE+I ISY+     TR R+++L    FF C C +C
Sbjct:   19 ASNGLGRGLFAYTDIRTCDDILHIQDPFVA---VLKTERLQDTCSGCFGKRHFDSYSGQEVSLKACTGC-HVVKYCDKSCQSKDWKLTHSRECVIF---RNLKPKVLPVNARALLRMVLRTEARKNAYTEEELVLFQTLETHIDDILNRNAPQAERIALTSRAVKEYSKTDMEEEKIVAYHARLDLNSFNLTNDDDIGIYLHPYAALINHSCDYNAVVGFD-GSEIFVKAIRPIATGEQIFISYIDTTYPTRIRQKELQERYFFTCNCAKC 281          

Query:   20 AAKDRGRGLFACHEISK-DTVIYKESPFVVGPPIIGENR--TVCITCSNTIHYLENFCRKCSVEMCSNCSHLLE----------------EECSLFEKHRNTQKLKSASNWIAILRVILRTD--------ELSIPWKKLEDHSNNNY-RMKFYKDYIANDLKKVHH----EANESEVLKIASILDSNSFRINKHSLRGLF--GVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRC 256
            A+   GRGLFA  +I   D +++ + PFV    ++   R    C  C    H+     ++ S++ C+ C H+++                 EC +F   RN +      N  A+LR++LRT+        E  + ++ LE H ++   R     + IA   + V      +  E +++   + LD NSF +      G++    ++ INH C+ NA V FD    + + + + I  GE+I ISY+     TR R+++L    FF C C +C
Sbjct:   19 ASNGLGRGLFAYTDIRTCDDILHIQDPFVA---VLKTERLQDTCSGCFGKRHFDSYSGQEVSLKACTGC-HVVKYCDKSCQSKDWKLTHSRECVIF---RNLKPKVLPVNARALLRMVLRTEARKNAYTEEELVLFQTLETHIDDILNRNAPQAERIALTSRAVKEYSKTDMEEEKIVAYHARLDLNSFNLTNDDDIGIYLHPYAALINHSCDYNAVVGFD-GSEIFVKAIRPIATGEQIFISYIDTTYPTRIRQKELQERYFFTCNCAKC 281          

Query:   18 IKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLEN--FCRKCSVEMCSN--CSHLLEEECS----LFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKK---LEDHSNNNYRMKFY---KDYIANDLKKVHHEAN---ESEVLKIASILDSNSFRINKHS---LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQT-------NDILWNCIECGFETQDEKVNNLLQFIVKKLE-NNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHILSQRLDILHILEG 379
            ++ ++D GRGL A   I+   VI +E+P V GP   G +   C+ C   +  L    FC  C++  CSN  CS    +EC     L  K  + + L   +  I +LR +L  +     W +   L+DH       K     + ++ N L+ +  + N   + E+ ++  ILDSN+F    +     R LF +S+  N  C PN   +  R   + +++ + I KG+E+ I Y         R++ L+ +K F C C RC DPTE G+++SS+ C +CQ G ++Q         D+ W C +CG E + +KV  +   I + L+  N +S   L+   +   K L   H I+LE    LI    K    E  ++ + +    L +L +LEG
Sbjct:  259 LRYSEDSGRGLIATRSINTGEVIMEETPAVWGPKADGAS---CLECGLQLQDLSAVVFCNLCNLHFCSNPCCSSHPSKECKEMQKLIIKTDSLECLGKLTLVIVVLRCLLLPETAPQNWARMRLLQDHLEERKETKLQNLNQMFLVNFLRDIGLDRNYVSDKEIHRVCGILDSNAFESKTYEGLESRALFPLSAMANSSCLPNMTHVTRRDRKMVMVATRDIMKGQELLICYTGIRWGKLTRQKHLLLTKNFLCCCPRCLDPTECGTYISSIKCSQCQ-GNVIQNIQTAPDQQDLCWFCQDCGVEVEHKKVVAVEVMIGQILKLVNKNSTAHLEGASRKLGKLLSSQHYILLEMYMSLIALYEKR--EEKPERIVELCGIVLPVLTLLEG 1410          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSN-----------CSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTDE------LSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANES--EVLKIASILDSNSFRINKHSL---RGLFGVSSFINHDCNPNARVIFDRKGHLH--LISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN----DILWNCIECGFETQDEKVNNLLQFIVKKLE--------NNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLI-------DQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTS 405
            GR LF   ++    VIY E P VVGP    E   VC++C   I      C  C    C             C  L      +FE + N      A + I  LR++L+  +      L       E+    +   +F + +I   L++   ++  S  E++    IL+ N++ I    L   RGLF ++S ++H C PN R+I++ +      +++ + ++ GEEI+ SY+ P + +  RR+ +    +F C+C RC DPTELGSH ++LLCP C+ G ++  +    D +W C +CG +   + V  L++  +++++        N +  +D  D+    F    PQ H ++ E  K ++        +      + +I  K+ +    L +L I+E      +  F +  +YEL+  +IYL S
Sbjct:  276 GRQLFTTQDVRSGEVIYVEDPIVVGPS--QECEPVCLSCLAAID-TSYLCSGCGYPFCDEDCAADPAHSLECKVLANAPPPMFEDNTNL-----AYHPILPLRLLLQQSQDMNKARLVESLMDHEEERKGSEYWEFSQKHIVQFLQESCKQSQWSSEEIMNAIGILEVNAYEIKNIILCGYRGLFPLASLVSHRCVPNCRMIWNTEAPYQNKVVAAQDLKAGEEIATSYLRPSMCSLVRRKSIKQGWYFDCECARCCDPTELGSHANTLLCPACRAGHLLPLHPLDYDSVWLC-KCGHQETSQAVTELVEGFLEEVKVLYENDRYNAAQWLDMFDRAKVYFH---PQ-HEVISEIAKWVLPILGRGHGKTLSDFPVSMIKTKVELGINYLAVLDIVE----RGISKFRAKTMYELVDSQIYLAS 1496          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKHR--------------NTQKLKSASNWIAILRVILRTDELSIPWK---KLEDHS----NNNYRMKFYKDYIANDLKKV--HHEANESEVLKIASILDSNSFRI---NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHL--HLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN----DILWNCIECGFETQDEKVNNLLQFIVKKLE--------NNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLI-------DQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTS 405
            GR L    ++ K  VIY E P VVGP    E   +C+ C   I      CR C    C       +EEC+    HR                   ++A + I  LR++L+  +     +   +L DH      ++Y + F ++++   L++     +    E+     +L+ N + I        RGLF ++S ++H C PN +++ + +      +++ + ++ GEEI+ISY+ P + +  RR+ + +  +F C C RC DPTELGSH ++LLCP C+ G ++  +    D +W C +CG +   + V  L++  +++++        N +  +D  D+    F    PQ H ++ E  K ++        +      + +I  K+ +    L +L I+E      +  F +  +YEL+  +IYL S
Sbjct:  276 GRQLVTTRDVIKGEVIYVEDPIVVGP--TQECAPICLCCLRAIG-TSYLCRGCGYPFC-------DEECAADPSHRLECQVLSNATPPVLGGDGQRNAYHPILPLRLLLQQSQNPTRARLAEQLMDHKEERKGSDYWV-FSEEHVVKFLRESCKQTQWTNEEIRNAIGVLEVNGYEIKNLQTCGYRGLFPLTSLVSHKCIPNCKMVLNTEAPYTNKMVAGQDLKAGEEIAISYLRPSMCSLIRRKAIKNGWYFDCICSRCCDPTELGSHTNTLLCPACRAGHLLPLHPLDYDSVWLC-KCGHQETSQAVTELVEGFLEEVKVLYENDRYNAAQWLDMFDRAKVYFH---PQ-HEVISEIAKWVLPILGRGHGKTLSDFPVSMIKTKVELGINYLAVLDIVE----RGISKFRAKTMYELVDSQIYLAS 1499          

Query:   40 IYKESPFVVGPPIIGENRTV---CITCSNTIHYLENFCRK--CSVEMCSNCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRI-----VQTNDILWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKR------------------LIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKI-YLTSKSS 408
            ++ + P V+GP      RT    C  C       E  C    CS E C    H  EEEC + +K    +     S+W+ +LR  L  D+      ++     +N         I + L       +E +V +++S+L SN+FR  + S R +    + +NH C  N RV +++   L L +KK I  GE+++I+Y + LL T  R+ KLM SK F C C RC DP+E G+++  L C KC  G +     V   +I W C  CGF+   +KV+  L     KLE   + I+ L  +  +  +   Q ++  +E K +                  L+     S T  V+ ++  ++ QR+ +L +++    SRLKGF  +++Y +L  ++  LTS+ S
Sbjct:    3 VFNDWPVVIGP----SERTSEGECDGCYAERGRGECVCGLVFCS-EACRGRWHS-EEECEMIQKLPKPRP--HPSSWLLVLRAALSKDD------RIRLLEGDNTLRSPANSQIMSSLG-----ISEEDVAQLSSVLTSNTFR--RGSARCVCPAVAMVNHSCMANCRVHWEQGDKLVLTAKKNINAGEQLTITYCSTLLGTYARQTKLMKSKGFKCVCPRCLDPSESGTNMGGLTCTKCSNGYLLPHLMVDQPEIDWLC-ACGFQANSQKVSKFLD----KLEGELADIEQLGASDLNHLRIKAQLYTTWIEKKSKLLPPSSDLLLRAGGSLALLLSHMGSSET--VLGKREKLIRQRIKVLDMVDRKSMSRLKGFELFKLYLVLSERLKLLTSQKS 1112          

Query:    2 INEFSINLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLE-NFCRKCSVEMCSNCSHLLEE---ECSLFEKHRNTQKLKSASN------WIAILRVILRTDELSIPW---KKLED---HSNNNYRMKFYKDYIANDLKKVH-HEANESEVLKIASILDSNSFRINKHS---LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCP--KCQKGRIVQTNDIL-----WNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFL 389
            + EF  N+      + ++  + RGR + A  ++    VI +E P   GP  +  +   C+ C   + Y +  +C  CS+ +C     L+ +   EC L    ++   L S  +      ++ +LR +    +    W   KKL     H   +    F + Y+ + L+     E +E+E+ ++  I DSN+F  ++ S    RGL+ ++S +N  C PN R  F   G + +++ + I  G EI   Y  P   T  R + L ++K+F C C RC DP E G+  S+L CP  KC    + + + ++     W C++CG      KV        + +    + +++L   ++        +H  ++E K   + +         +S+ L+ ++ K+    +   I+ ++EGD  SR KGF+
Sbjct:  332 MGEFRQNMVFGDAGIRVEVKEGRGRCIVANKQLEVGDVIIEERPVAWGPKQL--SPPCCLACCAPLEYTQITWCSTCSLPLCRQDCSLINKHTPECELMAHAKDMLILNSERDVQQVYYFVTVLRCLWLRAKSPTQWEAAKKLVSNLAHRKGSKVFNFNQTYVVDTLEHFGIVEFSETEIQEVCGIFDSNAFESSESSRVACRGLYLMASLMNSSCLPNTRHYFKPDGRIAVVATRPIYPGAEILACYTQPRWGTGPRHKHLQNTKYFSCSCPRCMDPEECGTWCSALKCPNSKCPGAVVAKKSVVVDPKTDWACVKCGAVIIHRKVLTYQNCGSQMVHTRDTGVESLLSLLEKLSAWFYPAHYTIVEIKMAAVKEWGDGGPVSYESLALKDLELKITFCEELEKIIGLIEGD-MSRTKGFI 1588          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLE----EECSLFEKHR---NTQKLKSASNW---IAILRVILRTDELSIPWK-------KLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHS-----LRGLFGVSSFINHDCNPNARVIFDRKGHLHLI-SKKTIEKGEEISISYV---APLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN---DILWNCIECGFETQDEKVNNLLQFIVKKLENNSSS-----IDTLDKTIKSFEKKLPQSHSIMLEYKKRLID-------QQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYE---LLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRI 432
            GR L A  +IS   V++ + P  VGP      + VC+ C   +  L   CR CS  +CS      +     EC +F+K+    N         W   I +LR++   +     WK        LE+    + R     D+I N  K  H +  E E+  +  ++D+N++ I ++      L+GLF ++S INH C+ N  + F R        + K I+KGEE++ +Y+           RR +L     F C C RC D TE G+   +L+C +C++GR++  N      W C  C      E V  ++ +    ++  S       ++ L KT+K F+K    +H   LE K+R+I+        + + +    +++K+      L+I  IL     S  + +LS  I E    L  K YL  K   V G ++ K   ++ +H+ +  +I
Sbjct:  245 GRLLMASRDISAGEVLFNDIPGAVGPD--NNPKPVCLNCYKRMPGLVYRCRHCSWPLCSPFCQREDGPHARECQMFQKYSPRFNIADFTKPCPWYNAIMVLRILWLKENKPETWKLLDMLMDHLEEEKVESKRKNGVIDFIHNHCKLTHFK--EKEIRHVIGVIDTNAYIIGENPNKDVDLQGLFPITSIINHSCSANT-ICFARDNFTFACRAVKNIKKGEELTTNYLHYHYHFFGLSYRRPELSEFWHFKCNCHRCKDFTEFGTLSDALVCKECEQGRLIPLNMNPGSEWVCSTCYGSQTSEDVMMVITYWWNIIDTASKYDIKVLMELLQKTLKVFDK----NHYYNLEVKRRIIENIGDSKGNKYEDLAEAWLEKKVEFCKDHLNIQKILAPGL-SEYRAYLSSHIAEPLYWLTKKRYLAKK---VSGEELNKIMEEVAQHLLMVIQI 1561          

Query:    9 LYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCS------NCSHLLEEECSLFEKHR---NTQKLKSASNW---IAILRVILRTDELSIPWK-------KLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHS-----LRGLFGVSSFINHDCNPNARVIFDRKGHLHLI-SKKTIEKGEEISISYV---APLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN---DILWNCIECGFETQDEKVNNLLQFIVKKLENNSSS-----IDTLDKTIKSFEKKLPQSHSIMLEYKKRLID-------QQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYE---LLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRI 432
            LYE+ C          GR L A  +IS   +++ + P  VGP      + +C+TC   +  L   CR CS  +CS      +  H    EC LF  H      +  K +  W   I  LR++   +     W         LED    +  +    D+I N  K    +  E+E+L +  I+D+N++ I ++      L+GLF ++S INH C+ N  + F R        + K I+KGEE++ +Y+           RR +L     F C C RC D TE G+   +L+C +C++GR++  N      W C  C      E V  ++ +    ++  S       ++ L KT+K F+K    +H   LE K+R+I+        + + +    +++K+      L+I  IL     S  + +LS  I E    L  K YL  K   V G ++ K   ++ +H+ +  +I
Sbjct:  405 LYEERC----------GRLLMAARDISAGEILFTDIPGAVGPD--NNPKPICLTCYKRLPGLVYRCRYCSWPLCSPFCQQDDGPH--ARECQLFRIHSPRFEIEDYKKSCPWYNAIMTLRILWLKENKPDTWNLLDMLMDHLEDTKEEDKIVTGVVDFIRNHCKLT--QFTENEILHVMGIIDTNAYIIGENPNKDVDLQGLFPITSIINHSCSANT-ICFARDNFTFACRAVKNIKKGEELTTNYLHYHYHFFGLSYRRPELSEFWHFKCNCHRCKDFTEFGTLSDALVCKECEQGRLIPLNMNPGSEWVCSTCYGSQTSEDVMMVITYWWNIIDTASKYDIKVLMELLQKTLKVFDK----NHYYNLEVKRRIIENIGDSKGNKYEDLAEAWLEKKVEFCKDHLNIQKILAPGL-SEYRAYLSSHIAEPLYWLTKKRYLAKK---VSGEELNKIMEEVAQHLLMVIQI 1739          

Query:    5 FSINLYEKSC-KLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSN-CSHL---LEEECSLFEKHRNTQKLKSASN----WIAILRVILRTDELSIPWKKL---EDHSNNNYRMKFYKDYIANDLK-----------KVHHEANESEVLKIASILDSNSFRINKHSL---RGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL 286
             S ++Y+ SC    I+++   GR L A  +I    +I  E P   GP      R  C++C  ++   E  C  C+   C + C+     +E ECS+F K  +     S ++     +  LR++L  +     W+ +   +DH+++  R ++ +D +  + K            +     E E+    SIL ++S +   +S    R +F   +F++H C+ NAR +      + + +++ I+ G+E++I+Y + L S   R++KL S  FF C C+RC DPTELGS++SS+ CP C KG  +  + I+
Sbjct:  193 LSKHIYQGSCLPFRIESSPTLGRYLVASRDIEPLELIISEQPAAFGPSQFTTPR--CLSCLKSVRG-EYSCPSCNFPFCDDTCAKAQAHVEGECSVFPKFPSLPDFSSPASPQYECVTPLRLLLCKESQPEVWRHILLHKDHTDD--RRQYNEDAVEREQKVIVGLLLEWCRMIDSGYTEEEINMCISILSTHSVKFTPNSGTEGRAMFPTFAFMSHSCDYNARHVIQTDNTMQVFAQRKIKAGQEVTITYTSLLTSLPRRQDKLSSLWFFTCSCERCVDPTELGSNISSVACPACPKGGYLLPSHIM 1101          

Query:   18 IKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCS-NC--SHLLEEECSLFEKHR---NTQKLKSASNWIAILRVI---LRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIA----SILDSNSFRINKHS--LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLC--PKCQKGRIVQTNDIL---WNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVID-------QKLHILSQRLDILHILE 378
            + +A++ GR + A  +I     +    PF VGP +  +    C+ C      L + C KC + +CS  C  S+  + EC+L    +   N   LK     +  LR+I       EL      +E +       + +K    + ++ V     E   L I      I+ +N F +      L G++   + +NH C  N+R++ D    + +I+ + I+KG+    +Y   L +T  R+  L+ +K+F CQC+RC DPTELGS++SSL C   KC+   I +    +   W C++CG     E V  LL+ + K  EN + + +  +    K +  KL ++H ++ E K+ LI    +    E+ D       QK+ +  + LD+L I+E
Sbjct:  206 VTSAEEHGRNIVAARDIKAGETLMVTRPFCVGPRM-HKPALCCLGCHRAADKLMS-CDKCGLPVCSVKCAGSNTHQMECTLITNSKDKNNVTDLKLGIMVVTPLRIIGLKFTKPELYATAMSMEPNLEVLKERELWKYLDTHVIQPVLGLQIEGITLDIVERCVGIILTNCFEVMAKGCLLFGMYFEPALMNHHCVGNSRLMLDSSNLMTVIACQPIKKGKPAKWNYGRALDTTWTRQVNLLENKYFTCQCERCLDPTELGSNISSLKCREDKCEGSTIPKDPMSMKGDWICVKCGDVVNGECVRKLLKSLQKDTENLDRNDMKAVKDIFKKYAGKLHKNHGVLTELKQYLISGMGRLPGYEMDDLKESDHKQKVLLCQEVLDVLDIVE 1366          

Query:   14 CKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMC-SNC--SHLLEEECSLFEKHRNTQKLKSAS--------NWIAILRVILRTDELSIPWKKL---EDHSNNNYRMKFYKD-------YIANDLKKVHHEANESEVLKIASILDSNS--FRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKC---QKGRIVQTNDIL-------WNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEV-----IDQKLHILSQRLDILHILE-----GDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDNNC 439
            C  ++ ++ + GR L A  ++    ++  E+P V+GP  +     +C+ C    +  +  C KC   MC +NC  S + E EC+L        +L              +AILR +         WKKL   E H     + K Y+         I   LK         E+L +  +L+ N+    +    +  L+   S + H C  NA   FD    + + +   I+KGE ISI+Y  P+  T  R+  L  +K+F C+C RC DPTELG+  SS+ CP+C   Q G +V TN  L       W CI C        VN + Q I ++L      S++     I+   + L  +H  + + K  L     +S T +      + +K  +  Q++  + +LE         SRL+G + Y++   L         S  +    ++    ++ K++    +I S +  C
Sbjct:  203 CAYKVCSSPELGRYLVATRDLKPGEMVISETPLVIGPQSV--TIPICLACYKPANS-KYACGKCGWPMCNANCAKSPVHEAECTLTAARGAPLQLPPNCYNKPYPIYEVVAILRCLYLKQTSEAKWKKLKELEPHEEARKKNKRYEKDIDTMVRVIQEFLKIPETVFTTQEILDVCGVLNVNAHDLPVTPTPVMALYANISILEHSCINNASKHFDGDYRVVIRAAVNIKKGEHISINYSDPMWGTSSRQLHLNETKYFICKCVRCADPTELGTMFSSIQCPQCTAEQGGYLVSTNPGLGPESQADWKCIVCQKIQSHTFVNAVTQSIGEELVRLEKGSVEACQSFIRKHSQNLHPNHYYLQDIKLALCQMIGQSATGQGHEIFNLTEKELLYKQKIG-MELLEVANKISPGISRLRGVILYELQATLAAYARRKFSSGEISSDHMRNVMKEVKKYLLECIQIFSFEPPC 1600          

Query:    1 MINEFSINLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDILWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDNNCPPDLWKVEVQ 449
            MINEFSINLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDILWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDNNCPPDLWKVEVQ
Sbjct:    1 MINEFSINLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDILWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDNNCPPDLWKVEVQ 449          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF--CRKCSVEMCS-NCSHL---LEEECSLFEKHR---NTQKLKSASNWIAILRVI----LRTDELSIPWKKLEDHSNNNYRMKFYKD-------YIANDLKKVHHEANESEVLKIASILDSNSFRINK--HSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL----WNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLID--QQRKSITLEVID--QKLHILSQRLDILHILE-GDCDSRLKGFLSYQIYELLMGKIYLT-SKSSAVQGTDIQKWRLQILKHITVAKRIL 433
            GR L A  +IS+ ++I+ E P V+GP  +   + VC+ C N +   ++   CR+C+  MCS +CS        ECS+        N     +A+   A + V+    L+ D     + K + H N     + Y+        +  +   K+  + ++ E+L+    LD+N F I +   +LRGL+ + S ++H+C PN R  F+    +++ S   I+KGE I  +Y  PL  T  RRE L  SK F+C+CKRC DPTE G++LS+  C +C  G+++  + +     W C +C    +   V + ++ ++ +L++ + ++ + L+  +K +   LP+++ +  E +  L+   + R++  L+     +K  +  Q L + + ++ G    R +  L  Q   +++G+  L   + S +Q  DI     + +KH+  A R+L
Sbjct:  190 GRYLVAKDDISEGSLIFNEPPLVIGPRQL--TKAVCLXCHNELKDKKDTYPCRRCTWPMCSRSCSDSPVHANAECSILSYGGVKVNIDAFGTANMMYACITVLRALSLKNDHKWQEYLKFDSHLNERMPTQVYQQVNKEKVVFFIHYFLKLLSKFSDLEILEACGKLDTNCFEIRQFGKNLRGLYRIGSIMSHECTPNTRHTFEENYDINVYSTVDIKKGEIICATYTQPLWCTLSRREHLNMSKCFWCRCKRCSDPTEFGTYLSAFSCSEC-GGKMLPLDPLDQKSNWKCEKCSHTLESTTVRHGIESMMDELKSIDRTNPENLEDFLKRYATLLPETNQLTREIQLGLVSLFKNRRNEDLKTTQLLRKAFMCRQLLTVANRVDPGFSKWRGELLLEMQSANVILGQRALAEGRISNIQAKDIFD---ENMKHLKEADRVL 625          

Query:   14 CKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSN--CSHLL---EEECSLFEK--------HRNTQKLKSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIAND-------LKKVHHEANESEVLKIASILDSNSFRINKH--SLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLC-------PKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKS-FEKKLPQSHSIMLEYK 344
            C  ++   +  GR L    +I    VI++ESP  VGP    +   VC+ C   ++   + C  C+  MC N  C       ++EC+L               +K      ++  LR +L  +     W  LE   ++    K  + Y  N        L+++ ++    ++ K   ++D N+F I  H  S+ GL+ +++ +N +C+PN +   D      +++   I KG EI+ +Y   L  T  RR +L  SK+F C+C+RC DPTEL SH S+LLC        K  KG +   N +     W C  CG     E+V  L Q +  ++E    +ID  +  +K+   K L  +H I++++K
Sbjct:   67 CAYKLVKKEGHGRILIVTRDIEPGEVIFEESPITVGPKQFCQ--PVCLGCYKNVNGT-SICSGCNWPMCGNIECEKAPIHSKKECALLADCHLKPIIDLNKPEKDLPIYQFLTALRCLLVKEFRPDNWSILESMESHTELRKNEESYRVNQVNIVKFILERIKYDTTVEDINKCIDVMDVNAFEIRSHEFSIAGLYPMTAMMNSNCSPNTQNSIDENYICRVMAITRIPKGSEINSTYTRTLSGTLYRRNQLKESKYFDCKCERCCDPTELNSHFSTLLCQAILPSISKTCKGFVYSENSLNTNASWICRACGAVMSHEEVTELTQKLEVEIEKEFLTIDDYENFLKNRLLKFLHPNHYIIVDFK 428          

Query:   40 IYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMK------FYKDYIANDLKKVHHEANES-----EVLKIASILDSNSFRI----NKHSLRGLFGVSSFINHDCNPNARVIFDR--KGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN----DILWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRK-------SITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWR-LQILKHITVAKRILSEDNNC 439
            I +ESP+VVGP ++     +C  C + I ++   C K  + M  + +         FE             +I ++R++L  ++     K L   +N   +MK        ++  +  +++    ++ S     +V+   S L+SN++ +       SL  ++  SS INH CN N R +F +     L ++S K I K EEI+ISY+ P  +T +R++ L   K F C C+RC DP ELGS  S + C  C KG  +  N    D  W C EC    + EK   + + +V +L   N +SI  L+K +K++E  L   H  +L+ K+ LI+   +        + +  + +K+ +    L+    +E    S + G +  ++ + L  K  LT   S  Q   ++    L+ILK+  V     + D  C
Sbjct:   20 IMEESPYVVGP-VLQSKSQLCPGCHSPIAFVRLTCSKSPLSMKWDNNPFF-----FFEY---------LGGYITLIRLLLLNEK----GKPLNLVANMELKMKDPSKRACLEETASIVMERFVSTSSLSGVTIDKVITGLSQLESNAYEVLSPLTFESLMAVYLKSSLINHSCNRNTRTVFSKWPNYRLTVLSSKDILKDEEITISYLGPFHTTMQRQKILKRGKCFDCLCERCSDPLELGSFSSGIKCVYCSKGYFLAQNPLKRDSEWTCTECSSMIESEKAILMDESLVNELNKVNKNSIQNLEKFLKTYEPLLHPRHVFILQIKQFLIEGMGRLEGYNYDKMDVNALSRKISLCQDLLEAFKYIENPL-SFISGVVYLELTDTLYRKFLLTHDLSFKQSAKLKIVEALEILKYEDVMS---TTDGTC 426          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRK-CSVEMCSNCSHL---LEEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKL---EDHSN----NNYRMKFYKDYIANDLKKVHHEAN---ESEVLKIASILDSNSFRINK------------HSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQ 362
            GR L    ++ +  +I    P V+GP +    +  C+ C   +    + C   C   +CS+  H     EEEC L EK ++  K       + ILR  L        ++KL   EDH +    ++ R K  ++ +   LK++  + +   + E+ ++  I  +NSF + +             S++GL+ V S +NH C  NAR++ +   ++ + +   I     I+ +Y++PL     R++ L  +KFF C+C+RC DPTELG+  SSLLC  C+K    +T D       +C E   E    K+ N L     KL     +  T    +K ++  L ++H+ ++  K  L+     +  +  +D+
Sbjct:   59 GRQLRTARDVKQGDLIISAPPCVIGPRL-DYPKPSCLGCHVILDEKMSLCEGGCEYPLCSSECHRKFHSEEECKLLEKIKSPDK---RCEIVTILRFALLKKSNPRIYEKLILLEDHVDEIKASSTRWKNIEEGVLKHLKEIKSDLDIEEDQELERLVGIWITNSFELERTDQQLFGEKRAGESIQGLYDVPSLMNHSCVGNARLVINSGMYIDVYAAVPISNKAPITFNYISPLEDYDRRQKILKENKFFECKCERCEDPTELGTFSSSLLCQVCKKSPSTRTKDSKNYECRDCSEVMSERDAMKIANSLMKGKNKLHRIGKAWVTCIPFLKEYQDILWETHTFIIXIKMXLVXLXXSNXAISQMDE 422          

Query:   16 LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSN-CSH--LLEEECSLFEK--HRNTQKLKSASNWIAILRVILRTDELSIPW----KKLEDHSNN--NYRMKFYKDYIANDLKKVHH----EANESEVLKIASILDSNSFRIN-----KHS-LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL----WNCIECGFETQDEKVNNLLQFIVKKLENNSS-SIDTLDKTIKSFEKKLPQSHSIMLE 342
              +K     GR L A  +I    VI +ESP V+GP I   N+  C+ C  T+    + C  C+   CS  CS     + ECS F+K  H+  +      + I  LR++   +     W    K + DH+++   Y  + +  Y    +KK+       A+   + ++  ++D+N   +N     KH    GL+ + S +NH C  N + I  +   + + +   I KGE+I   YV P   T  RR  + +  +F C CKRC DPTE GS+L +LLC  C K  ++  N +     W C  C  E   E V  +L  + + LE  +    ++ +K +   +  L  +H + +E
Sbjct:   50 FAVKRNSQLGRHLVATRDIKALEVILEESPLVIGPYISSNNQ--CLECFKTLDTSPHSCISCNYPFCSQECSQGPWHKIECSAFQKYGHKRDENDNDFYSIITTLRLLSLQESKPEFWNTIMKDMLDHNSDIQEYTPEKWTSYEETVVKKIQSLTKGNADTDTLTRLIGVIDTNGADLNLPHDGKHGKGTGLYLIYSNLNHSCVCNTKTINFQDRRIEMRASVNISKGEQICNQYVRPNKCTLARRTTIKNKWYFDCCCKRCADPTECGSYLGALLCSSC-KSVVLPINPLETESNWACKGCSKEYDVEYVMGVLISVGESLEEATPYDPNSYEKILYDTQDLLHPNHYLRIE 399          

Query:   55 ENRTVCITCSNTIHYLEN----FCRKCSVEMCSNCS----HLLEEECSLFEKHRNTQKLKSA--SNWIAILRVILRTDEL---SIP--WK---KLEDHSNNNYRMKFYKDYIAND---LKKVHHEANESEVLKIASILDSNSFRI----NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI------LWNCIECGFETQD---EKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHILSQRLDILH--------ILEGDCDSRLKGFLSYQIY 394
            ++  VC+ C  +I   EN     C +C + +C  C     +L + EC      +  ++   A   N   +  V+L    L    IP  W     L  H       +     +      ++ +  E    EVL I  ILD+NSF I    +  +++ ++ +     H+C P     F+    L L +   ++ G+ I+I+Y   L  T ERR  L+ SK F C C+RC DPTE GS + +L C KC  GRI+  N +       W CI+CG+ +     E   N +  +++ +E+   + +  ++ I  + K L   H+ ML+ K  L+          + D   ++L  + DI          IL G   SRL+G   Y++Y
Sbjct:  436 DSSIVCLNCYGSIQD-ENEDISVCSRCGLPLCGQCDESELNLHKPECHALSSSKRGKRTSLALLDNVSLLFEVVLVLRCLHLRDIPENWSHFLGLTSHVGERRDSELEARALEASEXXIRDIGIEIPREEVLNICGILDTNSFEIPLPSSPGTIQAIYKIGCLPEHNCIPTGHRCFESDLSLVLRASVDLKAGDHITITYTDSLWPTMERRTHLLYSKHFSCICERCRDPTEKGSFIGALNCLKCGVGRILPENPLEDKNETSWICIDCGYVSPQGFAEDTYNQVAQVIQGMESGEINPEQCNRFITLYSKILNSQHAHMLDVKHTLLHLLGHHEGYLLGDLSNYLLQLKEDIARCLLQVAEKILPG--ISRLRGTTLYELY 814          

Query:   18 IKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCS---NCSHLLEEECSLFEKHRNTQKLK---SASNWIAILRVILRTDELSIPWKKLE---DHS------NNNYRMKFY------------KDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHSL-RGLFGVSSF-----INHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFI---VKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLID--QQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLM 398
            +K +K  GR + A  +I+   +I  E P VVGP    +    C+ C   +     +C KC V +C        L   EC  F+K+    K +   S+   +  LR++L        ++K++   DH       N    ++              K++  N++    ++ ++ E+ ++  IL +N  +       RG  GV+ +     INH C  N   +     HL L S+  I+KGE+I   YV+  +    RR+ +    FF C+C+RC D TELG+++S + C  C+ G ++  N +     W+C  C      + +++++  I   V+ +E+   +ID L++ +  ++K L  +H I+++    LI     ++++T    ++K+ +    L+ L  ++          L   IY L+M
Sbjct:  112 VKRSKRFGRYMVAARDINPLELILSEQPAVVGP--YSKKLPGCLNCFRLVD-GSYYCSKCGVPVCDKECEIGDLHRPECGYFQKNNFVIKKENHYSSQACVTPLRMLLMKKSDPNTFRKIDMLMDHIEERVVINKQVNIQLLNIILFLKEVSSSKEFNQNEVS-TSNDFDQKEIQRMLGILKTNGMKFEPLGPERGCPGVALYPVYCLINHACFNNTNYVKFPDFHLELRSQIPIKKGEQIFTRYVSSTIGNLRRRQDIKQYWFFDCECQRCIDRTELGTYMSGINCKHCKNGYLLPINSLNYESDWSCNNCDVIVNYKTISDIIDTIESQVRSIEH--ETIDELEEMLYHYQKLLHPNHYIVIDIMHNLIHVYAAKETLTRPEKERKIQLCMSVLETLGRVDPGYTKWRGTILQEMIYPLMM 528          

Query:   12 KSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCS-----NCSHLLEEECSLFEKHRNTQKLKSASN-------WIAILRVILRTDELSIPWK---KLEDHSNNNYRMKFYKDYIANDLKKVHH-------EANESEVLKIASILDSNS--FRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL----WNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKK---RLIDQQRKSITLEVID-------QKLHILSQRLDILHILEGDCDSRLKGFLSYQI 393
            + C  +I  ++  GR L A  ++    +I  E+P ++ P  +     VC++C   +      C  C   MC+     + +H+   EC +  +  +  K+    N        +A+LR +   ++ S  +K   +LE H+    +   Y       L+ +            + ++L +  IL  NS    +     + L+  +S + H C  NA   FD   ++ +     I+KGE ISI Y  P+  T  R++ L+ +KFF C+C RC DPTEL +H SS+ CP C  G +V  +       W C  C        VN +++ I ++L +    S +     +K   + L   H  +++ K    ++I Q       E+ +       QK  + ++ L++ + +     SRL+G + Y++
Sbjct:   45 RCCSYKICNSEXLGRYLXATRDLKPGELILMEAPTIIAP--MAVTPPVCLSCYAPVDG-RYMCPLCGWPMCNEICRNSPAHI--PECRITAERGSPIKIAVTINKPFPLYEVVALLRCLYMKEKSSEKYKALIRLEPHTKERIKNGKYSRDKMTMLRVIREFFSVPSTRFPDEDILALCGILFVNSHEVPVTMSPSQALYQNASLLEHSCVNNASKHFDMNCNILIRVAIPIKKGEHISIMYSDPIWGTVNRQQHLLETKFFTCRCIRCQDPTELNTHFSSIRCPGCPAGFLVSLDPFNYESDWKCETCNRVETPRFVNAVIRSIGEELISLEKGSPEACLSFVKKHSQNLHPHHFYLMDVKLALCQMIGQSSYGTGSEIFELHEKDLLQKQKLCTEILEVANKISPGV-SRLRGVVMYEL 459          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF---CRKCSVEMCS-NCSHLLEE---ECSLFEKH--------RNTQKL----KSASNWIAILRVILRTDELSIPWKKLEDH-SNNNYRMK--FYKDYIANDLKKVHH----EANESEVLKIA-SILDSNSFRI--------NKHSL-RGLFGVSSFINHDCNPNARVIFD-RKGHLHLISKKTIE--KGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN----DILWNCIECGFETQD---EKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYK-------KRLIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIY 394
            GR + A  +I     +  E P   GP     N  +C+ C   +  L+N    C  C   MCS  CS +LE    EC+  E H        +NT K     +S  N I+++R ++        W  +  H S++  R K  F++   A  L+ +         + + +KI   I   N F I         K SL RG+F ++S  NH C  N    F  R+    +  K  ++  +G+EI+ SY  PL     R+  L   KFF C C RC DPTE+ ++ S+L+C KC+KG ++  N    +  W C  C         E+VN+  +  +++++ N   ++T ++ +  +      +H  M++          R+   +  S++ +   +K  +  + L +L+++     +R KG + Y+++
Sbjct:   40 GRYMVATRDIKPGETVLMEYPLTFGPG--NPNEPICLGCYTPV--LKNQHTECDGCGFPMCSKECSQILEHKDFECA--EMHNMNFRLDSQNTLKWNGSQESVYNAISLMRALVLKKRDPARWNLIWMHMSHDEARQKDTFWQKKDAKTLEHIKAMMKISPEDYDTIKIILGIFLVNDFEICIPLEGSDEKSSLIRGIFALASMPNHSCVSNCYHNFTCREEGFKMTMKAVVDIKEGDEITHSYTEPLDPIMRRQSLLKIGKFFQCNCIRCRDPTEMSTYSSALICSKCKKGNVISKNCKNINSDWECDSCDLTLSPDSVEQVNSKAKSEIEEMDKN-PDVETHEQFLNKYATIFHPNHVYMIDRSYVLGKMYGRMEGYEPDSLSDDQFMRKKELCERVLKVLNVITPG-QTRKKGMMMYELH 454          

Query:    8 NLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCR-KCSVEMCSNCSHLLEE--ECSLFEK--HRNTQKLKSASNWIAILRVI--LRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANE----SEVLKIASILDSNSF----RINKHS--LRGLFGVSSFINHDCNPNARVIFDRKGHLHLI-SKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPK--CQKGRI-VQTNDIL--WNCIECGFETQDEKVNNLLQFIVKKLEN--NSSSIDTLDKTIKSFEKKL-PQSHSIMLEYKKRLIDQQRKSITLEVIDQKL-HILSQRLDILHILE--GDCDSRLKGFLSYQI 393
            +L ++     I ++   GRG+FA  +I+   +I++E   V GP       + CI C  T+      CR +C++ +C  CS   E   EC  F +   ++    +   N ++ LR++  +R   L    + L D    N    + ++ I       +    +     ++ +I  +L++N+F    R   H   LRGLF +++ +NH+C PNA   F+  G L ++ + + I KG EI+ +Y   L     R   L  +K F C C RCHD TE G++LS+L C +  C+   I VQT  +   W CI C       K+     F +  + N  NS S+  +   I     +  P S+ +++E K  +I +  +    E   +++ H+   R ++L IL   G  +  LK  ++ +I
Sbjct:   49 DLRQEQPNWTISSSTVAGRGVFATRDIAAGELIFQERALVTGPTARKGQLSSCICCHETLPQTGFLCRHRCTLPVCETCSDSEEHQAECEHFRRWQPKDVDAEQEQVNPMS-LRILTAVRVFHLGKEQRHLVDAMQANAERAYRREIIQAAQCFRNFPTTDRVFMDQLFRIVGVLNTNAFEAPCRSGGHETLLRGLFPLTAIMNHECTPNASHYFE-NGRLAVVRAARDIPKGGEITTTYTKILWGNLTRNIFLKMTKHFACDCVRCHDNTENGTYLSALFCREQGCRGLVIPVQTRTLQPDWRCITCENVFPHAKMAKYQDFALNTINNRINSCSVQDMIHFINELCPRFCPSSNYVLIEAKLNVIWRMTRFDHEEYTPEEMGHMDRYREEVLAILHKLGAGECTLKKLITGEI 461          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPI-IGENRTVCITCSNTIHYLEN---FCRK-CSVEMCSNC--SHLLEEECSLFEKHRNTQKLKSASNWIAILRVI--LRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVL----KIASILDSNSFR----INKHSL--RGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPK--CQKGRI-VQTNDIL--WNCIECGFETQDEKVNNLLQFIVKKLEN--NSSSIDTLDKTIKSFEKKL-PQSHSIMLEYKKRLIDQQRKSITLEVIDQKL-HILSQRLDILHILE--GDCDSRLKGFLSYQI 393
            GRG+FA  EI+    +++E   +VGP      N   C  C   I    +    C   C + +CS C  S   + EC LF K +  +  +     + IL V+     DE S   +KL      N   ++Y   +        H   E ++L    +     ++N+F     ++ H +  R LF ++  +NH C PNA   F+    + + + + I  G EI++SY   L ST  R+  L  +K F C+C RC DPTE G++LS+L C +  C+   I VQT  +   W CI C       K+     F +  + N  NS S+  +   I     +  P S+ +++E K  +I +  +    E   +++ H+   R ++L IL   G  +  LK  ++ +I
Sbjct:   53 GRGIFATREIAAGEELFREHTLLVGPTAHRSMNLRTCTLCYRLIPGSTDSAALCPAGCGLPVCSECRDSTRHDLECKLFRKWKPLESQRIEPRALRILSVVRCFFLDEAS---RKLLYAMQANMD-RYYMQEVQRAADCFEHFPREQDMLDYFYRTICAFNTNAFESRSNVDGHEVLVRALFPLAGLLNHQCTPNAAHHFENGETIVVCATERIPAGAEITMSYAKLLWSTLARKIFLGMTKHFICKCVRCQDPTENGTYLSALFCREQGCRGLVIPVQTRTLQPDWRCITCENVFPHAKMAKYQDFALNTINNRINSCSVQDMIHFINELCPRFCPSSNYVLIEAKLNVIWRMTRFDHEEYTPEEMGHMDRYREEVLAILHKLGAGECTLKKLITGEI 447          

Query:   16 LEIKAAKDRGRGLF-------------ACHEISKDTVIYKESPFVVGPPIIGENRTVCITC-----------------SNTIHYLENFCR-KCSVEMCSNCSHLLEEECSLFEKHRNTQKLK---------------------SASNWIAILRVILRTDELSIPWKK---------LEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHSLR---GLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRC 256
            +EIK  K+  RGLF                + +K  +I+KE PF+  P II  N  +C  C                      Y    C+ K S+E  S          +  EKH + +K +                     S S W+ +  +        + WK          L+  +N + + KF  D+    ++ ++          I   +D N       S     GL+ ++SFINHDC+PNA + F     +HL   K I  G+EI+ISY        +RR +L  +  F C+CK+C
Sbjct:   37 VEIKDCKN-NRGLFYNPIESPTQTLSVINPKTNKPNLIFKEEPFISYPSIIKSNENICNHCLKEIKKEEEEIKQECEECKVYKYCSIECKEKSSIEYHSVLCKSTGSGFNYLEKHASIEKRRFPLLAGKILARMIMGYHLEKSSKSTWLPLQMLSFAKKPPPLEWKDDYLIFSRSLLKGINNESMKKKFDYDWFVRVMQILYLNT-------IGIDIDPNQQSTKMSSPESGIGLYLLTSFINHDCDPNAFIHFPDDHTMHLSPLKPINPGDEITISYTDTTKDLVDRRSQLFENYGFNCECKKC 333          

Query:   18 IKAAKD--RGRGLFACHEISKDTVIYKES-PFVVGPPI----IGENRTVCITCSNTIHYL-ENFCRKCSVEMCSNCSHLL-EEECSLFEKHRNTQKL--KSASNWIAILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHE--------------------ANESEVLKIASILDSNS----------------------------------------FRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRC 256
            +K  KD  +GRGL+A  +  KD +I+KES P VV P +    + +    C  C   + +L ++F    S++ C NC  +    EC   +   NT K   KS  N I            S+ W K E + N+N  +  Y   +   L  +  +                     NES+   I    D++S                                        + IN+ S + +F + S INH+C PN R        + + ++K I  G+E+  +Y+ PL   + RR +L  +  F C C RC
Sbjct:  116 VKNCKDGHKGRGLYALKDFVKDDLIFKESYPIVVVPSMERLTLMKMGKACSLCGGLLSHLSKHFIVVHSLD-CDNCGGVWCSNECKNIDIGHNTLKHLHKSKINGID-----------SVAWGKFEKYCNDNVFVAAYSIGVIMALALIDKKNTDKIRKKFNLLSSVSQGIRINESDSTNIGGTFDASSGAMSNKDPEPIWKTSYELLKNAIPTTDELDMETYLSYIGRYNINQISDQ-MFFLPSLINHNCEPNVRFEVVSNKEIRVYARKNISAGQELLTNYINPLHGVKLRRRELRVNYGFLCHCDRC 412          

Query:   15 KLEIKAAKD--RGRGLFACHEISKDTVIYKES-PFVVGPPI-------IGENRTVC-ITCSNTIHY--LENF-CRKCSVEMCS-NCS-----------------HLLEEECSLFEKHRNTQKLKSASNWIAILRVIL----RTDELSIPWKKL---------EDHSNNNYRMKFYKDYIANDLKKVHHEA--NESEVLKIASILDS------------NSFRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTEL 262
            K+EI+  ++  +GRGL+A  +I +  +++ E  P  + PP+        G++ ++C ++ SN+ H+  L    C  C+   CS NC                  ++   + ++FE+H       +A +   I    L    ++DE++  ++ L         E   +NN    F  D     LK+ + E    ++  L I +  D+              F IN+ S + L+ + SF+NH+C PN R   + K  L + ++K I+K EE+  +YV PL     RR +L  +  F C C RC    EL
Sbjct:  115 KVEIRECEELRKGRGLYATRDIQQGELLFHEKVPIAMVPPMDKLKLIRSGKSCSMCGVSLSNSSHFTMLHGLDCNGCNSIWCSTNCKQKDITHPYLKHFGSKNKNIRPMDWNMFERHCQENIFVAAYSIGVIHAASLIDKAQSDEINQQFEALAKISQRVRYESSDSNNIGGTF--DAEIGSLKEENPEPLWKKAFDLFIRTFPDTAEMGYEVFLEYLGRFHINQLSGQ-LYFLYSFLNHNCEPNVRYDINNKLELKVYARKFIKKDEELVTTYVNPLHGVSLRRRELRVNWGFICNCDRCAKEIEL 418          

Query:  174 NSFRINKHSLR----GLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCH 257
            NSF I    ++    GL+   S +NH C+PN  ++F+   HL L + + IE GEE++I Y+  L+++ ERR++L     F C C RC 
Sbjct:  181 NSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFN-GPHLLLRAVREIEAGEELTICYLDMLMTSEERRKQLRDQYCFECDCIRCQ 267          

Query:  185 GLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRC------HDPTELGSHLSSLLCP--KCQKGRIVQTNDILWNCIECGFETQDEKVNNL---LQFIVKKLENNSSSIDT-----LDKTIKSFEKKLPQSHSIML 341
            GLF + S INH C+PNA ++F+ +  + + +   I K  EI+ISY+    ST  R++ L     F+CQC RC      HD  E  + L    C   KC    +    +  + C +C      E+V  L   L+ + +K   + S+ D      L KTI+  + KL  S SI L
Sbjct:  204 GLFPLVSIINHSCSPNAVLVFEEQMAV-VRAMDNISKDSEITISYIETAGSTLTRQKSLKEQYLFHCQCARCSNFGKPHD-IEESAILEGYRCANEKCTGFLLRDPEEKGFVCQKCLLLRSKEEVKKLASDLKTVSEKAPTSPSAEDKQAAIELYKTIEKLQVKLYHSFSIPL 374          

Query:  174 NSFRINKHSLR----GLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCH 257
            NSF I    ++    GL+   S +NH C+PN  ++F+   HL L + + IE GEE++I Y+  L+++ ERR++L     F C C RC 
Sbjct:  181 NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFN-GPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQ 267          

Query:   16 LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITC----SNTIHYLENFCRKCSVEMCSNCSHLLEEEC----SLFEKHRNTQKLK----------------SASNWIAILRVILRTDELSIPWKKLEDHSN---NNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRIN--------------KHSLRG-------LFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKF-FYCQCKRCH 257
            + +   +  GR +FA  +I    +I+   P V  P ++  + +VC  C      +  + +     CS E   N    L+ E     S F+ +  T   K                  ++ + IL+  + + E+     K+ED      N +R   +KD     L K  + A       I + +  N+FRI+                S+ G       ++ + SF NHDC+PNA +I+       L + + +E+GEE+ I Y+   +   E R+ ++S  F F C C RC 
Sbjct:   44 IRVGLTESAGRAVFATRKIGAGDLIHTAKPVVACPSLLKLD-SVCYLCLKKLMGSAKFEDRGVSYCSQECQENSKGFLDVETRADWSSFDDYCRTHNFKYPLMVKRLCCMIISGARPADCLDILQPAVLSSEMI---SKIEDGYGLLWNAFRKANFKDDDVAFLTKQWYTA-------ILARIRINAFRIDLVGGSCGEDLLSLAAASVEGEGAVGHAVYMLPSFYNHDCDPNAHIIWLHNADARLNTLRDVEEGEELRICYIDASMGY-EARQTILSQGFGFLCNCLRCQ 322          

Query:   16 LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKHRNTQKLKSAS------NWIA--ILRVILR------------TDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHH-------EANESEVLKIASILDSNSFRINKHSLR----GLFGVSSFINHDCNPNARVIFDRKGHLHLI-SKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRC 256
            LE  A+  +GRGL A    +   +++   P       + E  + C  C         F RK  +  C  C           ++     KL+ A+      NW     +R+  R              E  +  K+ E H +     K  ++ I ND+  +HH         + + ++ + + ++ N F I    L      +F   + +NH C PN  VI   KG L  + + K IE GEE+  SY+  L  T +R ++L  S FF C C+ C
Sbjct:   12 LERFASPGKGRGLRALRRYAVGELLFS-CPAYTAVLTVSERGSHCDGC---------FARKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECAAMCAFGQNWNPSETVRLTARILAKQKIHPERTQSEKLLAVKEFESHLDKLDNEK--RELIQNDIAALHHFYSKHMEYPDNAALVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPN--VIVTYKGTLAEVRAVKEIEPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCDCREC 270          

Query:   16 LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSV--EMCS---------------NCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPWKKLED-HSNNNYRMKFYKDYIANDLKKVH--------HEANESEVLKIASILDSNSFRINKHS--LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKT--IEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCI---EC-GFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRK-------SITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLM 398
             E+K +K  GR + +   +    VI  E+P V+GP      +  C+ C  T+    +FC KC+    +CS                C+ L   + S F  + N ++++   N I  LR +L  +  +  ++ L    ++N  R    + +  N    V          E ++ E+  +  IL+ NSF I +    +RGL+  +  ++HDC PN   I D +    L  + +  IE GE I++SY   L ST +RRE L+ +KFF CQC+RC DPTELG+  S+L+CPKC+ G ++ +N +     W C    +C G++   + +  LL  I ++++N + + + T++  +K +   L  +H I L  K  L     +        ++ EV+ +KL I  + + + +++E    +RL+G   Y+++  LM
Sbjct:   40 FEVKTSKVMGRYMVSRKNLKPGDVILSEAPLVIGP--CTGCKVQCLGCYKTLE--SSFCTKCTCGWPLCSPKCKGLGKRFGHSQVECAVLKATKSSKFLNYDNFEEMRPNFNAIVPLRCLLLKETDARSYQHLMTMETHNEIRRNIPELWQTNQRTVVDKIRIDWGLREYSQEEIHSVCGILEVNSFEIGQQGVNIRGLYPSAFLMSHDCVPNTNHI-DEESTFRLTVRASTRIEPGEMITLSYAYTLQSTLKRREHLLENKFFECQCRRCSDPTELGTFTSALICPKCKDGFVLSSNPLDPEADWTCSNYNKCPGYKISAKSMQLLLDKITQEVDNIDCNDVITMETFLKKYRNVLHPTHYINLSVKLSLSQLYGRINGFLIDELSDEVLTRKLEICEEIIKVFNVIEPGF-TRLRGVTLYEMHAPLM 462          

Query:   17 EIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSN-CSHLL--EEECSLFEKHRNTQKLKSAS----NWIAILRVILRTDELSIPWKKLEDHSNN--NYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRI------NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL---WNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKL----PQSHSIMLEYKKRLI 348
            EIK ++  G G+FA   I    +I+K+ P ++GP         C++C +    L    +KC + +CS  C   L  ++EC +  + ++    +  S      ++ +R +L  +E     K L+ H ++   + +   KD +A ++K    E  E  +  + S++DSN+F +      N+ S++GL+ + S  NH C PN   +FD K H+ + + K I +G EI  SY   + ST  RR  L  +K F C+C+RC DPTE GS++ S+LC  C+ G+++ TN +    W C  CG   + E+V N+   +   L  NS   D +   ++   +KL    P+++  ++E K +LI
Sbjct:   29 EIKKSELGGFGVFATRAIEVGELIFKDFPVILGPRAAPTCPLSCVSCYSR-RDLRLCGKKCGLLVCSEKCEKSLGHQKECKVVRQWQSKPISEDLSVQLVRVLSPIRSLLLGEEDKSVVKCLKAHKSDQHGFEVDVMKDALALNVK----EDEEKFMRFVCSVMDSNAFEVLVGFEDNQASVKGLYPLGSLANHSCCPNTCHVFDDKQHMVVRASKFIPQGSEIFHSYSRLIWSTSARRFHLYRTKHFLCKCQRCEDPTEFGSYIGSILCKVCKTGKVIPTNSLQTDKWQCEVCGSLIKKEEVANITFVLGSAL--NSFDDDDVAVMLRLLHQKLPNLVPENNQTVVELKYKLI 375          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF--CRKCSVEMCSNC---SHLLEEECSLFEKH------RNTQKLKSASNWIAILRVIL-------RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKH----SLRGLFGVSSFINHDCNPNARVIFDRKG-HLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL-----WNCIECGFETQDEKV---NNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRL------IDQQR-KSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDNNCPPDL 443
            GR + A  +I    VI +  P +VGP +   +  +C+ C   +   E+   C KC   +C      S L E EC +F K       +N    ++    IA LR +L       R + L      L+DH          K  +    + +  + NESE+L I SI D+N F +       ++RGL+   SF++H C  N +  F+     L L +   I+KG+ ++ +Y   L  T  RR  L  +K F C C+RC DPTE G++LS++ C  C  G  V ++D L     W C  CGF      +   N +LQ  +  L  N  + ++L++ ++ + + L   +S  L+ K  L      +D  + + ++ ++ID+K+ +  + L +  +LE    S  +G L Y ++E L+ K       +  +G DI +   +   ++T A +I   +    PD+
Sbjct:    9 GRCVVATRDIRSGEVIAESLPLIVGPKMA--SPPLCLGCHKKLALAESRYDCSKCFWPLCGQACESSPLHEAECEIFAKAGYKPTVKNDNSKQTVYCPIAPLRALLLKKNSPERFNLLLDFQSHLQDHEKTQVYQVLKKSLVPFFTQLLKLDTNESEILTICSIFDTNCFEVRDTQRLVNIRGLYPTISFLSHSCKHNTKHCFNGDNFRLVLTATTPIKKGDLVTTTYTQTLWGTLSRRSHLKMAKHFDCLCERCTDPTEFGTYLSAVNCSVCGDGSKVTSSDPLNCEADWFCENCGFAITGSDMLWGNEVLQKEINHL--NKDNPNSLEEFLERYAEVLHGRNSYCLQVKYALCQIYGSLDGFKFEELSSDLIDRKIELCKELLAVAEVLEPG-QSWFRGLLLYDLFEALVAK-------AERRGEDIDE---ETKNYLTEAAKIFDSE----PDM 446          

Query:    1 MINEFSINLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGP------PIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEE--------ECSLFEKHR--NTQKLKSASNWIAILRVILRTDELSIPWKK---LEDHSNNNYRMKFYKDY---IANDLKKVHHEANESEV----LKIASILDSNSFRINKHS------LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL---------WNCIEC-----------GFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSIT-----LEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIY 394
            M+ E S ++   + K ++  ++  GR L A  ++    VI +E P  VGP      PI  E  ++       ++Y+   C  C+V   + C    EE        EC + + +   + +     +  + +LR+ L   +    WK+   LE H N       ++D    I N LK ++   N+  V     ++  ILD NSF +          LRGL+  +S + HDC  N  V  D   HL + +   I++G+ I  +Y + LL T  RRE L + K+F C+C  C DP E+GS++S ++CP+C++G +   + +          W C +C                   V+++ ++ +K +EN        DK  KS  K    +H +ML  K++L++  R+ IT      +++   +H+  +  D+L I+E    SRLKG + Y+I+
Sbjct:    2 MMEEKSKDVATPTLKYKVAYSEKLGRYLQASKDLRAGEVILREDPVAVGPMSCVKDPICFECLSILPNIEEDVNYV---CSGCNV--VTLCGVTCEERGIYHSAYECEIIKNNEELSIENTDVLAGVLFVLRLWLLKQKDPELWKRVLSLESHLNKRRNTIVWEDREINIVNVLKSLNFLENDPSVSEMIQQLCGILDVNSFELRSPGGMDGLLLRGLYLEASMMAHDCRGNVHVTADDNFHLTVYASIPIKEGDTIFFNYTSSLLGTTGRREYLRTGKYFECECDLCKDPYEMGSYMSCIVCPRCRQGYVGMQDPLTKFPYTKSAKWQCNKCKKIISGCLIKTSLSISKNLVDDVDEYNIKVMEN------LKDKLSKSLHK----NHFLMLSLKQKLLNVYRQEITGPNPKRKIMRSMVHLCKEMFDLLEIVEPGI-SRLKGIMLYEIH 436          

Query:   26 RGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKC-SVEMCSNCSHLLEEECSLFEKHRNTQK--LKSASNWIAILRVIL--RTD-----ELSIPWKKLED-------HSNNNYRMKFYKDYIANDLKKVHHEANESEVL-KIASILDSNSFRINKHS----------LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIV-QTNDILWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRK--------SITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLM 398
            R L A  +I    +I  E P VVGP    +     I+C   +      CR C    +C +CS     ECS +E+     K  L    N I  LR +L  R+D     E+       E        H +N Y ++   +    D +++       E+L +I  ILD N+F I  +            RGL+  +S + H+C  N  +  D    L L S   I+ GE +  +Y   L ST ER+  L   K+F C C RC DPTELG+HLSSL C  C  G  V       W C+ CG +   E VN ++      + + +     L+K I    K L   HS++LE K+ L  + R         ++  + + +KL +  + L IL +L+    SRL G   Y+ +  L+
Sbjct:    1 RFLVANRDIKPGELILAEDPIVVGPYWDAD-----ISCLGCLGPASRTCRVCLKGPLCRDCSRHDPVECSFYEQASKLNKNFLFDHFNIITPLRCLLLYRSDRDKYNEMMAMESHFESRRDTEIWHIHNQYVVEPMLN--EKDFQQIDDLTVTGELLQRICGILDVNTFEIRGNMDSQGVQMNNLARGLYPKTSLMTHNCQTNTLIAVDGMSKLRLYSSIGIKAGELLYYNYTRVLFSTFERQTHLRKGKYFICNCARCSDPTELGTHLSSLKCTACDDGLCVFHPETPKWECLTCGHQLPREYVNQIMCEARDDISSCALDSRNLEKVIGKHSKTLNPHHSLVLEAKQSLAGELRNMCMSYDIHNVPRQALKRKLELCEEMLQILRVLDPGV-SRLTGIALYEYHAALV 402          

Query:   16 LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCS-HLLEEECSLFEKHRNTQKLKSASNW--------------------IAILRVILRTDELSIPWKKL---EDHSNNNYRMKFYKDYIANDLKKVH-----HEANESEVLKIASILDSNSFRI----NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL----WNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEG 379
             EI   +  GR L A  +I     I KE+P V+GP +   +  +C+ C   +  L     + +   CS+CS  L  +EC     H+   +L S SN+                    I +LR +   D+    + KL   EDH         Y+   AN +  +       +  E ++L+IA+ILD+N+F +     +  +R L+  ++ I+HDC PN R  FD   ++  ++K+ I KGE +SISY  PL ST +RR  L  +K F C C RC DP ELGS   +  C KC+ G+I+  N +L    W C  C F+   + V      + ++LE+ + ++   L++ I      L ++++ +L+ K  L            + ++ E +++KL +  + L +  I +G
Sbjct:   49 FEIATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVA--SAPLCLGCHRNL--LAPGKPRGNYHKCSSCSWPLCGKECEDSVHHKAECQLMSGSNFQSKINYVPGEEERKESAYCVIMLLRCMHLKDKDPDAFLKLYNLEDHLKERLETPLYQVLRANLITFIKTVLGMKDWPEMDILRIAAILDTNTFEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRKIAKGEILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCLKCKAGKIISLNPLLNSAPWKCQLCNFKRSAKDVVTSDAELQQELESLDKTTPVALEEFIYRHRADLHETNTHILQAKYALTQLYGSAPGFAMEELSGESLNRKLQLCEELLKLADIFDG 453          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLE-NFCRKCSV-----EMCSNCSHLLEEECSLFEKHRNTQKLKS---ASNWIAILRVILRTDELSI-P---------WKKL------EDHSNNNYRMKFYKDYIANDLKKVHHEANESEVL--KIASILDSNSFRIN---------KHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL----WNCIECG--FETQDEKVNNL--LQFIVKKLENNSSSIDT-LDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQK------LHILSQRLDILHILEGDCDSRLKGFLSYQIYELLM 398
            G  + A  ++    +I KE P ++GP I   +  +C+ C   I + +  FCR+C +     E CS  S   + EC  ++K     K+      SN+  +L +   + +L + P         W          D   N     +Y++ I   L  V+   +E  +L  KI  ILD NSF +           + LRG++  ++F++HDC  N  V  +    + + +   I+ G+ I  +Y  P   T  R+++L   K+F C CKRC DPTELG++  S++CP+C +G I+  N +     WNC +C   F  Q  K  N+     +    E NS+ ++  L K +KSF    PQ++ +M E K++LI   R +I  ++  QK      +    + +++L I+E    SR KG + Y++Y+ ++
Sbjct:    3 GTFMVASKDLKPGEIILKEQPLILGPSI--NSNILCLGCFRRILFEKFKFCRECQIAPVCGEDCSLKSQHSKYECKYYKKLFENDKIDKNFIVSNFQIVLPLKCFSLKLFLFPDDDDDDDHLWDNFINMESHVDERQNEPIWNYYQENIIKVLNSVNILNDEECLLMQKICGILDVNSFEMRCPDDEQISAGNQLRGIYREAAFMSHDCIGNTHVSLNDFFEMTIHASVPIKSGQAIFFNYANPFECTAARQQRLKKGKYFNCFCKRCTDPTELGTYSGSIICPRCHEGCIISQNPLSDSSGWNCEKCNHFFYNQLIKATNVEGQNLLSDVDETNSTQLENLLKKCLKSF----PQNNYVMTEIKQKLITSLRDTIRNQMNPQKKILIKIIRFCREMINLLEIIEPGI-SRHKGIVFYELYKPML 420          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITC-SNTIHYLENFCRKCSVEMCSNCSHLLEE-----ECSLFEKHRNTQ-KLKSAS------NWIAILRVILRTDELSIPW----KKLEDHSNNNYRMK--FYKDY--IANDLKKVHHEAN---ESEVLKIASILDSNSFRINK---HSLRGLFGVSSFINHDCNPN-ARVIFDRKGH-LHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKG----RIVQTNDILWNCIECGFETQDEKVNNLLQFI------VKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVI-------DQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQG 412
            GR L A   I    ++ +E PF VGP   G    VC+ C        E  C +C   +C  C+   +      ECS  +  R    +L S S      + I  LRV+L  +     W      +E H     R    ++ D   IA  L+     AN   E  ++++  +L+ N+F       + LR LF  +  + H+C PN +R I+  +G+ + L +   +E+G+ +  SY   L  T +R++ L   KFF CQC+RC DPTELG+H SSL C +C +G    R     D  WNC  CG +T +     +LQ +      V+ L   +  ++ +++ ++ ++  L   H I    ++ LI+   +    E++       ++K  +  Q L +L+  E    SR +    Y+++  L+    L +KS  + G
Sbjct:   21 GRYLVAKGAIRGHGLLIEELPFAVGPKCNGP--VVCLGCYEPNPDPEEELCSECGWPLCVECAQQADNAHFRLECSQLKDARARFFRLPSGSRHCPQLDCIMPLRVLLAKEANPERWDNEVAPMEHHKEERQRDADVWHADRVNIAQYLRGPCQLANRFSEELIMQVVGVLEVNAFEARSPKGYPLRCLFPYTGILAHNCVPNTSRSIYPSEGYKIRLRAMVDLEEGQPLHHSYTYTLDGTAQRQKHLKQGKFFTCQCERCLDPTELGTHFSSLKCGQCAEGFQVPRQPTEPDTSWNCANCGSDTSNADALAMLQSLQSEVNAVQALPMAAKRLEEIERLLRKYKSLLHPLHFIATGLRQLLIEMYGRVQGYEMVQLPDHQLERKAELCRQVLRVLNTFEPGL-SRTRAMNLYELHVPLV----LLAKSGFIAG 447          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITC-SNTIHYLENFCRKCSVEMCSNCSHLLEE-----ECSLFEKHRNTQ-KLKSAS------NWIAILRVILRTDELSIPW----KKLEDHSNNNYRMK--FYKDY--IANDLKKVHHEAN---ESEVLKIASILDSNSFRINK---HSLRGLFGVSSFINHDCNPN-ARVIFDRKGH-LHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKG----RIVQTNDILWNCIECGFETQDEKVNNLLQFI------VKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVI-------DQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQG 412
            GR L A   I    ++ +E PF VGP   G    VC+ C        E  C +C   +C  C+   +      ECS  +  R    +L S S      + I  LRV+L  +     W      +E H     R    ++ D   IA  L+     AN   E  ++++  +L+ N+F       + LR LF  +  + H+C PN +R I+  +G+ + L +   +E+G+ +  SY   L  T +R++ L   KFF CQC+RC DPTELG+H SSL C +C +G    R     D  WNC  CG +T +     +LQ +      V+ L   +  ++ +++ ++ ++  L   H I    ++ LI+   +    E++       ++K  +  Q L +L+  E    SR +    Y+++  L+    L +KS  + G
Sbjct:   21 GRYLVAKGAIRGHGLLIEELPFAVGPKCNGP--VVCLGCYEPNPDPEEELCSECGWPLCVECAQQADNAHFRLECSQLKDARARFFRLPSGSRHCPQLDCIMPLRVLLAKEANPERWDNEVAPMEHHKEERQRDADVWHADRVNIAQYLRGPCQLANRFSEELIMQVVGVLEVNAFEARSPKGYPLRCLFPYTGILAHNCVPNTSRSIYPSEGYKIRLRAMVDLEEGQPLHHSYTYTLDGTAQRQKHLKQGKFFTCQCERCLDPTELGTHFSSLKCGQCAEGFQVPRQPTEPDTSWNCANCGSDTSNADALAMLQSLQSEVNAVQALPMAAKRLEEIERLLRKYKSLLHPLHFIATGLRQLLIEMYGRVQGYEMVQLPDHQLERKAELCRQVLRVLNTFEPGL-SRTRAMNLYELHVPLV----LLAKSGFIAG 447          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF-----CRKCSVEMCSNCSHLLE-----EECSLFEKHRNTQKLKSASNW-------IAILRVILRTDELSIPW----KKLEDHSNNNYRMK--FYKDY--IANDLKKVHHEAN---ESEVLKIASILDSNSFRINK---HSLRGLFGVSSFINHDCNPN-ARVIFDRKGH-LHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKG----RIVQTNDILWNCIECGFETQDEKVNNLLQFI------VKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVI-------DQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQG 412
            GR L     + +  ++ +E PF  GP    ++  VC+ C   + + E+      C  C   +C +C+   +      EC +F   R T     + +        I ILRV+L  +     W      +E H     R    ++ D   IA  L+     AN   E  ++++  +L+ N+F       + LR LF  +  + H+C PN +R I+  +G+ + L +   +E+G+ +  SY   L  T +R++ L   KFF CQC+RC DPTELG+H SSL C +C +G    R     D  WNC  CG +T +     +LQ +      V+ L   +  ++ +++ ++ ++  L   H I    ++ LI+   +    E++       ++K  +  Q L +L+  E    SR +    Y+++  L+    L +KS  + G
Sbjct:   13 GRCLATSSSVERGELVLEELPFARGPKR--DSGIVCLGCYQFLQFGEDGDSLDRCELCDWPLCGSCADDEDVTEHRGECQVFSAARVTFAGNVSDDGVCPQLDCITILRVLLAKEANPERWDNEVAPMEHHKEERQRDADVWHADRVNIAQYLRGPCQLANRFSEELIMQVVGVLEVNAFEARSPKGYPLRCLFPYTGILAHNCVPNTSRSIYPSEGYKIRLRAMVDLEEGQPLHHSYTYTLDGTAQRQKHLKQGKFFTCQCERCLDPTELGTHFSSLKCGQCAEGFQVPRQPTEPDTSWNCANCGSDTSNADALAMLQSLQSEVNAVQALPMAAKRLEEIERLLRKYKSLLHPLHFIATGLRQLLIEMYGRVQGYEMVQLPDHQLERKAELCRQVLRVLNTFEPGL-SRTRAMNLYELHVPLV----LLAKSGFIAG 443          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCS-VEMCSNCSHLL---EEECSLF----EKHRNTQKLKSASNWIAILRVILRTDELSIPWK-----KLEDHSNNNYRMKFYKDYIANDLKKVH-------HEANESEVLKIASILDSNSFRI--------NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDILWNCIECGFETQDEKVNNLLQFIVKKLENNSSSID--TLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMG 399
            GR L A  +I    +I+K+ P V+GP +  E   +C  C   ++   + C++CS V MC +C   L   EEEC++F    + H     LK+   +I  LR IL+    +   K      LE H +       ++ +  N +KK+H        E +   V KI  I+D N F +        +   +RGL+  ++ + H+C PN  +  D K  + + +   I KGE I  +Y +PL  T  R+E L   K+F C CKRC DPTEL +HLSSL+C +C+ G +V+ ++  W C +C  + + E +   +    + L N +   D   L+K +  F   L  +HSI L+ K+ L+   R+  + + + +K+ + ++ L +L  ++    SRL+G   Y+++  L+G
Sbjct:   59 GRYLIATRDIKAGEIIFKDQPCVLGPRVDIE--PICYNCYTPLYVPISTCKRCSLVPMCHSCKSELGHSEEECNIFSNALKDHNKEVILKALGQFIVPLRCILKLRNSAHDSKISKLLSLESHVDERRGTFVWESHHENVVKKLHIFGITTMTEKDVEYVQKICGIVDVNCFEVRGPMGVRGSGQPIRGLYVEAAMMAHNCVPNIHLSIDDKYEMVVRASSHIPKGEAIVYNYTSPLQRTEIRQEHLKEGKYFLCNCKRCTDPTELATHLSSLMCVRCKTGFVVKRDEKYWGCNKCEHKCKKELICCTITE-AEYLFNGTDPTDARALEKLLMKFAHTLSPNHSISLDIKQMLVTLYREVASAKALQRKIQLCNEILIVLMTIDPGI-SRLRGITLYELHVSLVG 459          

Query:   17 EIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLE----NF--CRKCSVEMCS----NCSHLLEEECSLFEKHR------------NTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVH-----HEANESEVLKIASILDSNSFRINK----HSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDNNCPPDLWKV 446
            E+      GR L A  +I K  +  +E PF+ GP +   +   C+ C  T+   E    NF  C +CS  +C       +H ++E C L    +             T K +SA   I  LR IL   +  E    + +LEDH N       YK   AN L  +       E ++ +VL++A+ LD+N+F + +      LR ++  ++ I+HDC  NAR  FD + H+  I+K+ I KGE I+ SY  PL  T  RR+ L+ +K F C CKRC DP EL +   ++LC KC+ G+I+ TN +    LW C  C  E   +++N     +VK++E+ N  S    ++ +  +   L + ++ +L+ K  L          Q   +    + +K+ +  + LDI  IL+G   S  +G L   + E L+ +     +   +  T++Q+   + ++ +  A  I+  +    PD+ +V
Sbjct:   48 EVATNDTLGRHLRATRDIKKGEIFLREKPFIYGPKVA--SAPTCLGCHRTLQAPEPPQTNFYKCTRCSWPLCGPQCERSTHHIDE-CELMTARKFNAKIDYNPNKEQTGKKESAYCVILPLRCILLKNKNPEAFARFSQLEDHLNERKDTPLYKILGANLLTFIKTVMGFSEWSDEDVLRVAARLDTNAFEVRQVATGQKLRAIYPNAAMISHDCVSNARHTFDAQMHILFIAKQKIAKGEIIATSYTQPLKCTLMRRQHLLQTKCFECTCKRCSDPEELSTFAGAILCSKCKIGKIISTNPLDNAALWKCQLCPHEIPAKQINWGNGAMVKEIESLNKKSPRVFEEFLHRYRDTLHEKNTHVLQVKYALTQLYGNAPGFQMHEMNDAAVKRKVELCQELLDIADILDGGF-SIFRGNLLLDLQEALVVQAKREFEQGLLTKTNVQEKLAEAMELLKEAVEIMKLE----PDMQEV 515          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLE----NF--CRKCSVEMCS-NCSHLLE--EECSLFEKHR------------NTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKV-----HHEANESEVLKIASILDSNSFRINKHS----LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQT----NDILWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKS-------ITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDNNCPPDLWKV 446
            GR L A  +I K  +  +E PF+ GP +   +  VC+ C  T+   E    N+  C +C+  MC  +C   L+  +EC +    +             T K +SA   I  LR IL   +  E    + +LEDH +       Y    AN L  +       E ++ +VL++A+ LD+N+F I + +    LR ++  ++ I+HDC  NAR  FD +  +  I+K+ I KGE I+ SY  PL  T  RR+ L  +K F C C RC DP ELG+   ++LC KC+ G+I+ T    N  LW C  C  E   ++VN     +VK++E+ N +S   L++ I  +   L + ++ +L+ K  L      +       +T   + +K+ +  + L++  IL+G   S  +G L   + E L+ +     KS  +   ++Q+   + ++ +  A  I+  +    PD+ +V
Sbjct:   56 GRHLRATRDIRKGEIFLREKPFIYGPKV--ASAPVCLGCHRTLTAPEPPQKNYYKCTRCTWPMCGPHCERSLQHVDECEIMAARKFNSKIDYYSSKHQTGKKESAYCVILPLRCILLHNKNPEAFARFAQLEDHLSERVNTPLYNILSANLLTFIKTIMGFSEWSDEDVLRVAARLDTNAFEIRQPATGQKLRAVYANAAMISHDCISNARHTFDEQMQILFIAKQNIAKGEIIATSYTQPLKCTLMRRQHLQLAKCFDCICTRCKDPEELGTFAGAILCRKCKVGKIISTDPLDNGALWKCQLCPHEIPAKQVNWGNNAMVKEIESLNKTSPRALEEFIHRYRDTLHEKNTHVLQVKYALTQLYGNAPGFLMHEMTDGAVKRKVELCQELLEVADILDGGW-SIFRGNLLLDLQEALVVQAKREFKSGLLTKANVQEKLAEAMELLKEAVEIMKLE----PDMQEV 515          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITC----SNTIHYLENF--CRKCSVEMCS----NCSHLLEEECSLFEKHR------------NTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVH-----HEANESEVLKIASILDSNSFRINKHS----LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQT----NDILWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRIL 433
            GR L A  +I K  +  +E PF+ GP +   +   C+ C     N +   +NF  C +CS  +C     N +H ++E C L    +             T K +SA   I  LR IL   +  E    + +LEDH N       Y+   AN L  +       E ++ EVL++A+ LD+N+F + + +    LR ++  ++ I+HDC  NAR  FD +  +  I+K+ I KGE I+ SY  PL ST  RR+ L  +K F C C RC DP ELG+   ++LC +C+ G+I+ T    N  LW C  C  E   +++N     ++K++E+ N  S    ++ +  +   L + ++ +L+ K  L          Q   +    + +K+ +  + L++  IL+G   S  +G L   + E L+ +     +S  +   ++Q+   + ++ +  A  I+
Sbjct:   56 GRHLRATRDIKKGEIFLREKPFIYGPKVA--SAPTCLGCHRSLPNPVPPQKNFYKCSRCSWPLCGPQCENSAHHIDE-CELMSARKFKAKIDFDPTKEGTGKKESAYCVILPLRCILLRNKNPEAFARFAQLEDHLNERMNTPLYRILSANLLTFIKTIMGFSEWSDDEVLRVAARLDTNTFEVRQAAAGQKLRAIYTNAAMISHDCVSNARHTFDDQMQILFIAKQKIAKGEIIATSYTQPLKSTLMRRQHLSQAKCFECTCARCKDPEELGTFAGAILCSRCKVGKIISTDPLDNGALWKCQLCPHEIPAKQINWGNGAMLKEIESLNKMSPRAFEEFLHRYRDTLHEKNTHVLQVKYALTQLYGNAPGFQMHEMNDAAVKRKVELCQELLEVAEILDGGW-SIFRGNLLLDLQEALVVQAKREFESGLLTKANVQEKLTEAMELLKEAVEIM 506          

Query:   10 YEKSCK-LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITC----SNTIHYLENF--CRKCSVEMCS-NC--SHLLEEECSLFEKHR------------NTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVH-----HEANESEVLKIASILDSNSFRINKHS----LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLM 398
            ++  CK  EI      GR L A  +I K  +  +E PF+ GP +   +   C+ C     N +    NF  C +CS  +C   C  S L  +EC L    +             T K +SA   I  LR IL   +  E    + +LEDH N       YK   AN L  +       E ++ +VL+IA+ LD+N+F + + +    LR ++  ++ I+HDC  NAR  FD +  +  I+K+ I KGE I+ SY  PL  T  RR+ L  +K F C C RC DP ELG+   ++LC +C+ G+I+ TN +    LW C  C  E   +++N     ++K++E+ N  S    ++ +  +   L + ++ ML+ K  L          Q   +    + +K+ +  + L++  IL+G   S  +G L   + E L+
Sbjct:   40 HKAECKCYEIAINDTLGRHLRATRDIKKGEIFLREKPFIYGPKVA--SAPTCLGCHRSLPNPVSPKNNFYKCSRCSWPLCGPQCEKSSLHIDECELMAARKFKAKIDYDPTKEGTGKKESAYCVILPLRCILLRNKNPEAFARFAQLEDHLNERINTPLYKILSANLLTFIKTIMGFSEWSDDDVLRIAARLDTNTFEVRQAATGQKLRSIYTHAAMISHDCVSNARHTFDDQMQILFIAKQKIAKGEVIATSYTQPLKCTLMRRQHLSQAKCFECTCARCKDPEELGTFAGAILCSRCKIGKIISTNPLDNGALWKCQLCPHEIPAKQINWGNGAMLKEIESLNKQSPRAFEEFLHRYRDTLHEKNTHMLQVKYALTQLYGNAPGFQMHEMNDAAVKRKVELCQELLEVAEILDGGA-SIFRGNLLLDLQEALV 471          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITC----SNTIHYLENF--CRKCSVEMCS----NCSHLLEEECSLFEKHR------------NTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVH-----HEANESEVLKIASILDSNSFRINKHS----LRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQT----NDILWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLM 398
            GR L A  +I K  +  +E PF+ GP +   +   C+ C     N +   +NF  C +CS  +C     N SH ++E C L    +             T K +SA   I  LR IL   +  E    + +LED+ N       Y+   AN L  +       E ++ EVL++A+ LD+N+F + + +    LR ++  ++ I+HDC  NAR  FD +  +  I+K+ I KGE I+ SY  PL ST  RR+ L  +K F C C RC DP ELG+   ++LC +C+ G+I+ T    N  LW C  C  E   +++N     ++K++E+ N +S    ++ +  +   L + ++ +L+ K  L          Q   +    + +K+ +  + L++  IL+G   S  +G L   + E L+
Sbjct:   56 GRHLRATRDIKKGEIFLREKPFIYGPKVA--STPTCLGCHRSLPNPVPPQKNFYKCSRCSWPLCGPQCENSSHHIDE-CELMSARKFKAKIDFDPTKEGTGKKESAYCVILPLRCILLRNKNPEAFARFAQLEDNLNERLNTPLYRILSANLLTFIKTIMGFSEWSDDEVLRVAARLDTNTFEVRQAAAGQKLRAIYTNAAMISHDCVSNARHTFDDQMQILFIAKQKIAKGEIIATSYTQPLKSTLMRRQHLSQAKCFECTCARCKDPEELGTFAGAILCSRCKVGKIISTDPLDNGALWKCQLCPHEIPAKQINWGNGAMLKEIESLNKTSPRAFEEFLHRYRDTLHEKNTHVLQVKYALTQLYGNAPGFQMHEMNDAAVKRKVELCQELLEVADILDGGW-SIFRGNLLLDLQEALV 471          

Query:   10 YEKSCK-LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITC----SNTIHYLENF--CRKCSVEMCS----NCSHLLEEECSLFEKHR------------NTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVH-----HEANESEVLKIASILDSNSFRIN----KHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQ-------QRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLM 398
            ++  CK  EI      GR L A  +I K  +  +E P + GP +   +   C+ C     N +   +NF  C +CS  +C     N S  ++E C L    +             T K +SA   I  LR IL   +  E  + + +LEDH N       Y+   AN L  +       E ++ EVL++A+ LD+N+F +     +  LR ++  ++ I+HDC  NAR  FD +  +  I+K+ I KGE I+ SY  PL ST  RR+ L  +K F C C RC DP ELG+   ++LC +C+ G+I+  N +    LW C  C  E   +++N     I+K++E  N  S    ++ +  +   L   ++ +L+ K  L          Q   +T   + +K+ +  + L++  IL+G   S  +G L   + E L+
Sbjct:   40 HKAECKCYEIATNDALGRHLRATRDIKKGEIFLREKPLIYGPKVA--SAPTCLGCHRCLPNPVPPQKNFYKCSRCSWPLCGPQCENSSQHIDE-CELMSARKFKAKIDFDPTKEGTGKKESAYCVILPLRCILLRNKNPEAFVRFTQLEDHLNERMNTPLYRILSANLLTFIKTIMGFSEWSDDEVLRVAARLDTNTFEVRQTTARQKLRAIYTNAAMISHDCVSNARHTFDDQLQILFIAKQKIAKGEIIATSYTQPLKSTLMRRQHLSQAKCFECTCARCKDPEELGTFAGAILCSRCKIGKIISKNPLDNGALWKCQLCPHEIPAKQINWGNGAILKEIETLNKLSPRAFEEFLHRYRDTLHDKNTHVLQVKYALTQLYGHAPGFQMHEMTDAAVKRKVELCQELLEVAEILDGGW-SIFRGNLLLDLQEALV 471          

Query:   17 EIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFC-RKCSVEMCSNC--SHLLEEECSLFEKHRNTQKLKSASNWI--AILRVILRTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRI---NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL----WNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHI----LSQRLDILHILEGDCDSRLKGFLSYQIYE 395
            E+  ++  GRG++A  +I    +I+ +SP ++GP  I EN   C++C N  + +   C   C + +C +C       +EC+     +  +   +    I  A +R +   D        LE H    + ++   D +   +     +  E+ +    ++LD+NSF +      +LRGLF +SS +NH C PN   +FD   H+ L + K I+KGEEI ++Y   L  T  RR  L+ +K F C+C RCHDPTE G++LS++LC  C  G ++  N ++    W C  C  + ++ K+  ++  + K+  + +   + + D      EK +P+ + + LE+  R I     +   E+ D+   I    L   LD+L  L+    S+++G L +++Y+
Sbjct:   29 EVGKSRFSGRGVYATRDIQPGEIIFVDSPVILGPRAIPEN--TCVSCYNDTNIV--LCPMSCGLYLCPSCLDGDKHSQECAKINSWKTEKSFVTDRMMICLAPIRSLFLDDSDRESISMLEAHREPQHGIEV--DLMKKKMLLELCDEEENWIRLTCAVLDANSFEVLPKTGPTLRGLFPLSSLLNHSCVPNVMHVFDEDHHMILKAAKPIKKGEEIFLTYSRILWCTLSRRTHLLRTKHFACECPRCHDPTEFGTNLSAMLCESCS-GFVLPKNPLIFNGVWTCNSCDRQVEESKIAFIMSVLAKRFSDVDEDHMKSFDLFRSKSEKIIPKCNQVSLEFMYRTIWILGGA---ELSDEHFQIKGECLKYVLDVLMKLDVGA-SKMRGLLLHELYK 413          

Query:   17 EIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF-CRKCSVEMCS-NCSHLLEE--ECSLFEKHRNTQ---------KLKSASNWIAILRVILRTDELSIPWKKL-EDHSNNNYRMKF------YKDYIANDLKKVH--HEANESEVLKIASILDSNSFRINKH---SLRGLFGVSSFINHDCNPNARVIFDRKGH-LHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLEN-NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRK-------SITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRIL 433
            EI+ +   GR L A  ++S   +I ++ P VVGP    EN  +C++C+  +    +F C  C   +CS +C++ +    EC   + H   Q         +L++    I +LR ++        WK+L E  S+N  R          +  I + ++K     E +E E+  I  IL+ N F +  +   S R LF  +  + HDC PN     D   H L + + KTI+KGE IS+SY   L  T +RR+ L  +KFF+C C+RC    EL +H S+LLCPKC  G I+ +N +     W C +C F    + V NL+  +  +L+    +++  ++  ++ + + L  +H I L  K  L     K        +  E++ +K  +    L+++ +LE    SRL+G + Y+++  +M ++    +   ++ +D ++   ++++ +  + +IL
Sbjct:   32 EIRHSDVFGRYLVAARDLSTSEIIIQQLPLVVGPIANDENAPICLSCNQALEIDNSFRCFGCKFPLCSAHCTNRIHTKFECQYLKTHNIFQYLHLNEHRSELENDYEAITVLRCLMLKISSEQSWKQLNEMESHNEIRKNMPALWNRNQKVIVDRIRKKWKLEEFSEDEIHTICGILEVNCFEVGGNKGTSARALFPEAYLMCHDCVPNTNHTDDPITHELTVRTTKTIKKGEVISLSYAYTLQGTLKRRQHLNEAKFFWCICERCKSSDELSTHASTLLCPKCTYGFILSSNPLDENAEWRCSKCSFSLAAQFVMNLVTKLFDELDAIGGNNVIEIEGFMRKYSRTLHNNHYIFLSAKHSLCQLLGKVEGYLINELNAELLKRKEDLCRDLLEVIDVLEPG-SSRLRGVILYELHAPVMLQLTRELQMGRIKNSDFKRRLKEVVQILNESYKIL 485          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLE-NFCRKCSVEM-----CSNCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVIL-----RTD-ELSIPWK---KLEDHS---NNNYRMKFYKDYIANDLKKVHHEANESEVL-KIASILDSNSFRIN--------KHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDILWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLD--------KTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEV------IDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIY 394
            GR L A   + +  ++ +E P V GP +   +  VC++C  T+       C +C         C   +H    EC+   + RN   +   + W+  LR  L     +TD E    W+    LE H      + R    + ++  +L++    +N++E++ K+ SI+D NSF I            L+G++  +S ++H C PN  +       L L +   +EKGE IS +Y  P+ ST ER++ L   K+F C+C+RC DPTELG+H++SL CP C K  I+   +  W C  C    +D+ V   + F  +++      +DTLD          +  F +    +H+IM++ K+ LI++ R ++ +EV      + +K+ +  Q L ++ ++E    SRL+G   Y  +
Sbjct:   53 GRHLIAARPLRQGELLLRERPLVAGPRV--GSTPVCVSCYRTLPGPRPRLCGRCGGAWVCGAPCEGGAH--AAECAAL-RGRN---VAVNAQWVLPLRCYLGVKGLKTDPEPDTRWQDVLGLETHEKERRGSVRWSVIQRFVVQELQEAGVISNDAELMHKLCSIIDVNSFEIRGPENASGRAERLKGIYQKASLMSHSCVPNTHLAVSNDFQLILRAAVPVEKGEIISFNYTGPIKSTTERQDMLSEEKYFLCRCERCLDPTELGTHMNSLNCPACHKDGILTKRETEWTCSNCSKTLKDDVVRTTI-FEARRV------LDTLDLQNQRALETVLARFSRTFHPNHAIMIDLKQMLIERYRSNLLVEVKPCKKLLRKKIELCRQILPVIRLIEPGI-SRLRGLTLYAFH 447          

Query:   24 RGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSN-CSHLLEEECSLFEKHRNTQKLKSAS--------NWIAILRVILRTD---ELSIPWKKLEDHSNNNYR--------MKFYKDYIANDLKKVHHEANESEVLKIASILDSNSFRINKHSLRGLFGVSSFINHDCNPNA-RVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLC--------PKCQKGRIV-----QTNDILWNCIECGFETQDEKVNNLLQFIVKKLEN--NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLID---QQRKSITLEVIDQKLHILSQRLDILHILE 378
            +GR + A  +I    +I  +     GP +   +  VC+ C   I  L++ C KCS  MCS  C+     E       +NT K+   +          IA LR +L  D   +    ++ L DH+    +         K+  D++  D +     +NE E+ +   +  +N+F  N    + +F   SF++H C  NA  V+F  K HL L +K  I+KGEE++ISY++PL ST  RR KL    +F C C RC DPTE G++L+SL C          CQ    +     + + + W+C +C      + V  L   + K+L++  N   +   ++    FE +L  +H +++  K+ +I    +    + LE + +   +  Q L++L+ L+
Sbjct:   53 KGRCMVASRDIQPLELILYDHTMAYGPKM--GSPPVCLQCLKPIRNLDHPCPKCSWPMCSQKCAQGKTHELECSSLAQNTAKVDFGNFHATHDHYRSIAPLRFLLLRDSHPKFYDQFQYLMDHNVERKKDTETWELYQKYVNDFLREDCELADRFSNE-EIDRACGLYWTNAFACNSGGGQAIFPTFSFMSHSCVSNANHVVFPNK-HLALQAKILIKKGEELTISYISPLQSTLRRRAKLRDKWYFECNCSRCLDPTEKGTYLASLKCGANLANSKGPCQGVMCIEELANEPSQVFWSCSKCSNRISGDSVLQLENVVAKELQDIENRRDVGLYEQVQTKFEVQLHPNHFLLVLLKRHIIALGCEDIYDLELEQLKKFQALCEQVLNVLNKLD 442          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF--CRKCSVEMCS-NC--SHLLEEECSLFEKHRNTQKLKSASN------WIAILRVILRTDELSIPWK---KLEDHSNNNYRMKFYKD-------YIANDLKKVHHEANESEVLKIASILDSNSFRI--NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI 285
            GR L A  +I   T    ESP V+GP  +  ++ VC+ C   +  LE+   C +C   +CS  C  S L E EC + +   +   ++S          I +LR +   D     WK   K E H +     + Y         Y  +   K+ ++ ++ E+L+    LD+N F I  N  +LR ++ V+  I+HDC PN +  FD    ++L +   I KG  IS +Y   + +T  RR  L  SK F+CQC+RC DPTE G++LS+  C  C  G+++ T  +
Sbjct:  281 GRHLVATTDIPAGTHFLNESPMVMGPRQM--SKPVCLGCHKELVDLESVVKCSRCLWPLCSRKCEDSKLHEPECRVIKYGGSKVNVESFGQVNMMYACITVLRALALQDGAQTIWKDYTKFESHLDKRMETEIYTKVNKEKVVYFIHYFLKLINKYSDLEILETCGRLDTNCFEIKQNGMNLRAMYRVACIISHDCCPNTKHTFDPDHSINLFATTNIRKGSIISATYTQSIWNTMNRRAHLYMSKCFWCQCRRCRDPTEFGTYLSANSCNAC-GGQVIPTQPL 561          

Query:   11 EKSC-KLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKHRNTQKLKSASNWIAILRVILRTD-ELSIPWKKLEDH----SNNNYRMKFYKDYIANDLKKV-HHEANESEVLKIASILDSNSFRINKH---SLRGLFGVSSFINHDCNPNARVIFDRKGHLH--LISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDIL-----WNC--IECGFETQDEKVNNLLQ-FIVKKLENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKS-----ITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTDIQKWRLQILKHITVAKRILSEDN 437
            + SC  +++ + KD GR  FA  +I    VI+ E+P VVGP  +   +  C+ C+  +           V   S+ ++ L                      I  LR+I  +D ++      L DH      N    +  +  + + L  +        +V++   +++ N+F I        RG+F ++S ++H C PNAR    R        I+   I +GEEI+I+YV  +L + ERR KL  + +F C+C+RC DPTELG++L  +LC  C     +   D +     W C   +C  E   E+ +  ++  + +K   +   I      ++   ++L  +H ++   ++ ++    KS     IT E++  K+H+ +  L +L+ +E    +R +G   Y++ E  +  + L  KS ++ GTD      + L+    A + L  D 
Sbjct:  473 DGSCSPMKVASQKDVGRCTFATRDIKAGEVIFNENPIVVGPNNVTTPQ--CLVCTKKL-----------VPKKSDLNYEL----------------------ILPLRLITHSDPDVRSLMATLMDHRVEKEANAQVWEHNRQSMVDPLTSILEGHFTSDDVIRAVGVVEVNNFEIYNPLDCGFRGIFPLTSLMSHSCTPNARHAIGRSAPWSSVCIASVDIPRGEEITITYVPLILCSSERRAKLKENWYFDCRCRRCLDPTELGTNLGGILCQACSPSGFLLPADSIDYNSKWICSRSDCQAELSAEECSQKVERLLTEKDHLDRKDIPGFLTFLQRAGEELHVNHYVLNSLRRWIVSLYCKSSTCSTITEEMLRSKVHLATLYLSVLNTIEPGL-TRNRGRALYELAEAQLAILSLQLKSGSLDGTDFLGTLEECLERAQEAAQCLEHDT 888          

Query:   25 GRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMC-SNCSHLL--EEECSLFEKHRNTQKLKSASNWIAILRVILRTDELSIPW---------KKLEDHSNNNYRMKF-YKDYIANDLKK---VHHEANESEVLKIASILDSNSFRINKH-----SLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYV---APLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN----DILWNCIECGFETQDEKVNNLLQFIVKKLENN-----SSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRLIDQQRKSITLEVIDQKLHILSQRLDIL-HILE-----GDCDSRLKGFLSYQIYELLM 398
            GR + A   I    VI+ + P  VGP     ++ +C+ C   ++     C  C   MC  +C+ L     EC++F+K +    +       +    IL    L + W           L DH++    +   ++  I + ++K   +  + +E EV  +  IL  NSF ++        L GL+  +S ++H+C  N ++           +   I +GEEI  SY      L  T  RR+ L ++  F C C+RC DPTE G+ +S++LC  C++G ++       +  W C  C        V    +  VKK E+      SS + +L+K ++  +  L ++H  +L+ K+RL+D        EV      IL  ++D   H+LE         S L+G+L +Q + + M
Sbjct:   52 GRYMVAKRNIYPGEVIFTDQPACVGPD--NSSKPLCLGCFRKVNGSYK-CPGCRWPMCCESCTRLPGHRAECTIFQKRKAVVNVPWFDKPCSYYDAILPMRILFLKWFNPKVYHLVTLLMDHNDQLDELTIKHRQRIIDFIRKTCRLGKDFSEEEVNHVLGILTVNSFVVHDTEEDNLDLIGLYPWTSIMSHNCVSNTKITTREDFSYVCHATTFIREGEEIVTSYHHYHYQLYGTAYRRKDLKNTWSFECLCQRCQDPTEAGTMVSAVLCEGCKEGYLLPITPHDFESSWRCNHCFSHVPHGDV----EAKVKKFEDELDTIKSSDVVSLEKLLRRMKYVLHENHYWILDVKRRLVDIWGNKPGFEVYKLPKEILENKIDFCDHLLEVTTKLSPGPSELRGYLLWQSHNVTM 457          

Query:   28 LFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF--CRKCSVEMCSN-CSHL----LEEECSLFEK------------------------HRNTQKLKSAS------NWIAILRVILRTDELSIPWKKLEDHSNNNYRMK--------FYKDYIANDLKKVHHEANESEVLKIASILDSNSFRIN-KHSLRG--LFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLEN---NSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRL-------IDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKS--SAVQGTD 414
            L A  ++    ++ +E+P V+GP +  ++   C+ C   I  +     C  C   +C   CS       ++EC                             H+ T  +  +S      + I +LR +   +     W  +    ++N+ M          +   +   LK+     NE E L+   I  +N+  +N  H  RG  L+   + INH C  N +VI  +   L + +   IEKG+EIS  YV PL +T  RR  L S  +F C+C RC DPTELGS+LS+ +C KC+ G ++  + +    LW C +C      + +   L  I+  +++    ++ I   ++ +  F   L   H I  +   +L       +     S +   +D+K+    Q LD      G  D     +    + EL   K++L  +   + V G D
Sbjct:    1 LVASRDVKTMEILLEENPCVIGPYV--KSPVQCLECFKPIPDVSQAFRCPGCQFPLCGEECSQSKLNHAQDECDQLSGGNLKIQKIPGDNGEKPKKRSKGKKHQETHSMAGSSACNFDYSIITVLRSLRLKERKPEVWNNIMQLVDHNHEMAQEGSPTWNLWMTEVIPRLKQFPG-INEQEALRFLGIGVTNNANLNLTHGGRGTSLYPTFARINHQCICNTKVIKQKDHKLQVRASGPIEKGQEISNQYVKPLNNTAIRRSILRSKWYFECKCPRCSDPTELGSYLSAFICSKCKSGTVLAQDPLDPESLWICRDCSTSFTVDYLQARLNEILASIDSAHLQTNLIHRYEECLHKFSHTLHPGHQIFTDLNSQLAILYGNPMYGDLSSWSRPSLDRKIQACQQVLDT----NGRVDPGFSAWREKILIELTRTKVHLAQRDLRAGVIGED 444          

Query:   16 LEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENF--CRKCSVEMCS-NCSHL---LEEECSLFEK---------------HRNTQKLKSASNWIAI-LRVILRTDELSIPWKK---LEDH--SNNNYRMKFYKDYIAN---DLKKVHHEANESEVLKIASILDSNSFRI----NKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPK--CQKGRIVQTNDIL-----WNCIECGFETQDEKVNNLLQFIVKKLENNS----SSIDTLDKTIKSFEKKLPQSHSIMLEYKK-------RLIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGTD 414
             +IK  +  GR + A  ++    VI +E P ++GP +  E+  +C+ C   +     F  C+ C V +CS  CS      E EC + ++               HR++   + A+  + I LR +L        +KK   LE H  +    + +   D       D  ++H  AN   V KI  I D+NSF +        + GL+  ++ + H C  N R++F     + + +++ I KG+ I  SY   L  T  RR  L   K F C+C RC DPTE+GS  S+ LCP   C    +V +   L     W C  C  ET       LL     ++E +     + +   +  ++     L   H++++E K+       R        +T   + +K+ +  + L  L +LE    S L   +    YEL    I      S   G++
Sbjct:   64 FQIKDDEIVGRYMVAARDLQAGQVILREKPCLLGPNL-EESDLICVVCYRVL-TPRGFLTCKLCQVPVCSVQCSQSESHREGECGVLKQKPLGFYSTWTNRELVHRSSPSAEHANFQLIIPLRALLLKKRDVQQYKKFMALESHVSAREGTQAEVNTDERVCRLLDQFRMHEAANRDLVQKICGIFDTNSFDLAIQGGGRGITGLYLNAAMMMHSCVKNTRLVFSHDHVMTIYAREPIHKGDPIHHSYTRVLAPTTLRRTLLFVGKHFSCECVRCKDPTEMGSLASAWLCPNSGCGPEGVVLSETPLDLSAPWTCRHCS-ETPYSVSEILLTERRLRMEMDRLKPLACVPAWEDFLERHASLLHPQHALLVEAKQTLSVGYGRFQGHFYAQLTPSQVQRKVQLCREVLATLRLLE----SGLAAEIGLATYELAFALIRWVQCQSTPSGSE 507          

Query:   14 CKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSN-----CSHLLEEECSLFEKHRNTQKLKSASN--------WIAILRVI-LRTDELSIPWK--KLEDHSNNN-YRMKFYKDYIANDLKKVHHEAN-------ESEVLKIASIL--DSNSFRINKHSLRGLFGVSSFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKC---QKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKL----ENNSSSIDTLDKTIKSFEKKLPQSHSIMLEYKKRL----------IDQQRKSITLEVIDQKLHILSQRL-----DILHILEGDCDSRLKGFLSYQIYELLMGKIYLTSKSSAVQGT 413
            C  +I ++   GR + A  ++    ++  E+P ++ P  +     +C+ C   +      C  C   MCS+      +H+   EC+L          +  SN         IA LR I L+     +  K  +LE H+       +  KD I   LK +    N       + EVL +  IL  +S+   +    +  L+  SS I H+C  NA   FD  G L + +   I KG+ I+I+Y  P+     R++ LM SKFF C C RC DP ELG++ SSL CP C     G +   N +     ++C  C  E   + VN +++ I ++L    + N  +  T    IK   + L ++H  +++ K  L          ++ Q  ++      +K  I+ Q+L      I +I+     SRL+G + Y++   L   IY   K +A + T
Sbjct:   49 CAFKICSSSVIGRHVVATRDLRPGELVLSENPLLIAP--MAYTVPICLACFKPVDG-SIRCTTCGWPMCSDLCIGSSNHV--PECTLNNSRGKPIPDEVGSNSVPNPIYEAIATLRCIYLKQSNPDVFEKLMQLEAHAEKRKLNGRVDKDQII--LKMIRRFFNISASLISDDEVLDLQGILFVNSHEVPVTPTPVLALYLNSSLIEHNCVSNASKHFDTDGSLQIRAAVHIRKGDHIAITYSDPMWGNANRQQHLMESKFFQCICNRCQDPLELGTNFSSLRCPSCPAQANGYLSSINPLDIHSPFSCDHCHCEESADYVNAVIRSIGEELVQLEKGNPEACLTF---IKKHSQNLHRNHFYLMDVKLALCQLIGKNLDTVEDQSNTVMDFRTREKDLIIKQKLCMELISIANIISPGI-SRLRGVILYELQSTL--AIYARKKFAAKEIT 487          

Query:   17 EIKAAKDRGRGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEE----ECSLFEKHR---NTQKLKSAS-----NWIAILRV-ILRT--DELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKVHH----EANESEVLKIASILDSNSFRINKHS----LRGLFGVSSFINHDCNPNA-RVI--FDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIV---QTNDILWNCIECGFETQDEKVNNLLQFIVKKLE-----NNSSSIDTLDKTIKSFEKKLPQSHSIMLEYK-------KRLIDQQRKSITLEVIDQKLHILSQRLDILHILEGDCDSRLKGFLSYQIY 394
            ++       R + A  +  +  +++ E P +VGP        VC+ C  T+      C++C   +C N    L++    EC LF+      + +KLK        + I  LRV I++T   + +  + +LE H +       ++D     L  ++       +E E+ +I  IL +N F ++  S    +  ++   S  ++ C PNA R I        + L +K  I++GE ++I+YV  ++ T  R+E L   K F CQC RC DPTELG+H SSL C +   G +V     +   + C +CG     + V  ++     + E     + S +++  +  +  + + L  ++ +ML  K        R+     +S+T   + +K  +  + L +L +L+    S+ +G + Y+++
Sbjct:   24 KVTTGSSSARHVLAKSKWDQGVILWTEKPILVGPRY--STTPVCLGCYGTVDG-SCLCQRCGWPLCDNACQYLDQHSQWECELFQSKGIKIDGKKLKYDQTEVMYDIILPLRVWIMKTKDPDQARDFFELESHVDTWTNTPAWRDGHTKVLGYLNDTLSLNVSEEELSRIFGILYTNDFSVDNPSGSVKITTVYKDVSMCSNSCIPNAIRSIGSIQEGFQITLRAKVPIQEGEGVTIAYVDNMIPTPIRQEHLQYGKHFTCQCPRCSDPTELGTHGSSLNCGQECGGEVVLDPVQDRGAFKCQKCGRVMAKDIVGKIMTKAYHETEALLASSGSETVELCEMFLTKYRRLLHPNNILMLRIKYGLSTMLGRVSGYLMESLTPVQVIRKRKLCEESLQVLDVLDPGLSSK-RGLIHYELH 438          

Query:   26 RGLFACHEISKDTVIYKESPFVVGPPIIGENRTVCITCSNTIHYLENFCRKCSVEMC-SNCSHLL---EEECSLFE-------KHRNTQKLKSASNWIAILRVIL---RTDELSIPWKKLEDHSNNNYRMKFYKDYIANDLKKV-------HHEAN--ESEVLKIASILDSNSFRINKHSLRGLFGVS-----SFINHDCNPNARVIFDRKGHLHLISKKTIEKGEEISISYVAPLLSTRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKCQKGRIVQTN----DILWNCIECGFETQDEKVNNLL 305
            R + A  +I    +I  E P V+GP         C+ C   +      C++C++ +C + C       + EC  F+       + R T  + S    +  LR++L   R  ++      L DH+ N       KD +     KV           N  +SE+ ++  IL +N  ++ +    G  GV+     S INH C+ N   +     H+ L S+  I KG+EI   Y++  L    RRE++  + FF CQC RC DPTE G+ +S++ C +CQ G ++ ++    +  W C  C +    +KVN ++
Sbjct:  171 RFMVATRDIEALEMILWEQPAVIGP--YTREAQGCLQCFQKVSSPYT-CQRCNLPVCDAKCQDGTLHKDNECQFFQAGVTEGGQARGTGTVPS-QICVTPLRMLLKRARDPKVFAQIDMLMDHATNG------KDLLTLSTLKVICMIRDQRQGTNFAQSEIQRMIGILRTNGMKLEQRGEDGTPGVALYPIYSLINHACSNNTNYVKYSDRHMELRSQVAIGKGQEIFTRYISSTLGNVRRREEIERNWFFRCQCPRCLDPTEFGTFMSAVRCFQCQSGYLLPSDAQDLESDWKCDRCEWIILHQKVNEVI 472          

Query:    1 MINEFSINLYEKSCKLEIKAAKDRGRGLFACHEISKDTVIYKESPFVVGP-PIIGENRTVCITCSNTIHYLENFCRKCSVEMCSNCSHLLEEECSLFEKH-----------RNTQKLKSASNWIAILRVILRTDELSIPWKKL---EDHSNNNYRMKFYKDYIAN----DLKKVHHEAN----ESEVLKIASILDSNSFRINKHSLR---GLFGVSSFINHDCNPNARVIFDRKGH--LHLISKKTIEKGEEISISYVAPLL--STRERREKLMSSKFFYCQCKRCHDPTELGSHLSSLLCPKC------QKGRIVQTNDI----LWNCIECGFETQDEKVNNLLQFIVKKLENNSSSIDTLD--KTIKSFEKKLPQSHSIMLEYKKRLID----QQRKSITLEVIDQKLHILSQRLDILHILE 378
            M N+F   L E S K   + A    + L A  +I     I+ E+P   GP P    +  +CI C + + +    C KC   +CS+       EC   ++H           R +++       + ++R +L        W+KL   EDH      ++  ++ +++    +LK    E+     ++++  +A I+ S+S +++  SL     ++     ++  C PN  + FD      + + S + I KGE+I+   +  L    TRERR+KLM  +   C C RC DP E GS  S+ +C KC       +G I+  N +     W C +C +    + V +LL  +   LE      + +     I S    L  +H +M+  K  L +    +  ++I + + D KL  +   LD+L + +
Sbjct:    1 MWNKFPA-LREASTK---RMASSVAKHLVAIRDIPPGKAIFSETPLAQGPSPDHPNDDDICIVCLSELDH-AMVCSKCFWPVCSS-------ECGRSDQHKMECATLAACARESEEDLLPLRHLVVMRCLLMKHRDQYAWEKLMDLEDHHGVQTLIRNVEEELSDMDRLELKYFIRESCGMGIKTDLDIVADIVQSSSIQVDCESLEPFPAMYLTGGLLSQACVPNTVLRFDEDKDFLMTVYSARKISKGEKITFCPLQHLTKSGTRERRKKLMR-RLINCFCDRCVDPEECGSFSSAFICQKCAPKGTEDRGLILPINPVEEESPWQCQKCNYSMTSDTVESLLSRLRDSLEATKCEDNEVKFRDFILSNRSILHPNHYLMIACKDGLFNLKTSEASRAIDISIAD-KLETVEMGLDLLKVAD 410